Affinage

VAMP8

Vesicle-associated membrane protein 8 · UniProt Q9BV40

Length
100 aa
Mass
11.4 kDa
Annotated
2026-06-11
100 papers in source corpus 42 papers cited in narrative 42 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

VAMP8 (endobrevin) is an R-SNARE (v-SNARE) that drives membrane fusion across two broad functional domains: the late endocytic/autophagic pathway and regulated exocytosis from specialized secretory cells (PMID:10982406, PMID:15363411). In the endolysosomal system, VAMP8 partners with the Q-SNARE complex syntaxin 7/Vti1b/syntaxin 8 to mediate homotypic late-endosome fusion, with VAMP7 substituting for heterotypic late-endosome–lysosome fusion, defining combinatorial SNARE specificity (PMID:10982406, PMID:15133481). In autophagy, VAMP8 assembles with STX17 and SNAP29 to execute autophagosome-lysosome fusion, a step required for canonical autophagy and xenophagy (PMID:20089838, PMID:34785650). In regulated secretion, VAMP8 forms complexes with syntaxin 4 and SNAP-23 (and syntaxin 3) to serve as the principal v-SNARE for stimulated exocytosis from a striking range of cell types: pancreatic acinar zymogen granules, where it specifically mediates granule-to-granule compound fusion (PMID:15363411, PMID:21733851); platelet dense and alpha granules (PMID:17065550, PMID:12130530); mast cell secretory granules (PMID:17618625, PMID:18203950); cytotoxic lymphocyte lytic granules (PMID:19830729, PMID:26124288); macrophage TNF-alpha granules (PMID:19564343); goblet cell mucin granules (PMID:22144578, PMID:31541089); endothelial Weibel-Palade bodies (PMID:30630984); and AQP2- and GLUT4-containing vesicles in epithelial and metabolic tissues (PMID:19841070, PMID:20876717). VAMP8 activity is post-translationally gated: mTORC1 phosphorylation blocks STX17-SNAP29-VAMP8 assembly and is countered by recruitment of the Sec1/Munc18 protein SCFD1 (PMID:34785650), while DRAM1 stabilizes lysosomal VAMP8 by competitively inhibiting CHIP-mediated ubiquitination at Lys68/72/75 (PMID:40595569). Beyond fusion, VAMP8 traffics the NOX2 oxidase to phagosomes and endosomes to support reactive oxygen production and MHC class I cross-presentation, a function pathogens such as Leishmania subvert by GP63-mediated VAMP8 cleavage (PMID:23870310, PMID:28688576). VAMP8-null mice exhibit accumulation of secretory granules and broad secretion defects across exocrine, immune, and metabolic tissues, with downstream consequences including intestinal mucus dysfunction and colitis susceptibility (PMID:15363411, PMID:31541089).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2000 High

    Established VAMP8 as the v-SNARE partner for syntaxin 7 in the late endocytic pathway, answering which fusion machinery drives late endosome–lysosome traffic.

    Evidence Co-immunoprecipitation and cell-free in vitro fusion assay with immunolocalization

    PMID:10982406

    Open questions at the time
    • Did not resolve full Q-SNARE composition
    • Homotypic vs heterotypic fusion roles not yet distinguished
  2. 2004 High

    Defined combinatorial SNARE specificity, showing VAMP8 with syntaxin 7/Vti1b/syntaxin 8 mediates homotypic late-endosome fusion while VAMP7 substitutes for heterotypic late-endosome–lysosome fusion.

    Evidence Antibody inhibition in cell-free fusion assay plus reciprocal Co-IP

    PMID:11278762 PMID:15133481

    Open questions at the time
    • Quantitative kinetics of complex assembly not measured
    • Regulation of complex selection unknown
  3. 2004 High

    Identified VAMP8 as the major v-SNARE for regulated exocytosis, redirecting it from a purely endosomal role to a secretory granule fusion machine.

    Evidence Targeted gene knockout in mice with zymogen granule accumulation and abolished stimulated exocytosis, plus Co-IP of syntaxin 4/SNAP-23 complex

    PMID:15363411

    Open questions at the time
    • Mechanism distinguishing exocytic from endosomal complex assembly unclear
    • Regulation of granule recruitment not addressed
  4. 2006 High

    Generalized VAMP8 as the primary R-SNARE for stimulated secretion across hematopoietic and immune effector cells, with VAMP2/3 as a minor backup.

    Evidence Multiple genetic KO platelet models, recombinant VAMP competition in permeabilized platelets and mast cells, clostridial neurotoxin treatment

    PMID:12130530 PMID:17065550 PMID:17618625 PMID:18203950

    Open questions at the time
    • Granule-subtype selectivity (dense vs alpha) mechanism not fully resolved
    • Coupling to calcium-triggered fusion unaddressed
  5. 2009 High

    Extended VAMP8 to lytic granule and cytokine secretion in cytotoxic lymphocytes and macrophages, separating granule exocytosis from upstream polarization.

    Evidence VAMP8-KO CTL and macrophage secretion/cytotoxicity assays with normal granule polarization, in vivo inflammation models

    PMID:19564343 PMID:19830729 PMID:20543108

    Open questions at the time
    • Compensability with Vti1b limits specificity
    • t-SNARE partners at the immune synapse not yet mapped
  6. 2010 High

    Placed VAMP8 at the autophagosome-lysosome fusion step, defining its role in autophagic flux and xenophagy.

    Evidence siRNA knockdown of VAMP8/Vti1b with LC3/LAMP1 colocalization, bactericidal and canonical autophagy assays, negative controls for syntaxin 7/8

    PMID:20089838

    Open questions at the time
    • Q-SNARE partner for autophagic fusion not yet identified here
    • Regulation of VAMP8 delivery to autophagic membranes unknown
  7. 2011 High

    Distinguished VAMP8's specific role in granule-to-granule compound exocytosis versus primary granule-plasma membrane fusion, mapping distinct syntaxin partners.

    Evidence Two-photon live imaging of primary vs secondary fusion in VAMP8-KO acinar cells plus Co-IP of syntaxin 3 vs syntaxin 2/VAMP2

    PMID:21733851

    Open questions at the time
    • Spatial control of compound vs primary fusion not resolved
    • How VAMP8 is partitioned between granule populations unknown
  8. 2010 High

    Broadened VAMP8 function to epithelial and metabolic vesicle trafficking, including AQP2 exocytosis and GLUT4 endocytosis.

    Evidence VAMP8-null mice with hydronephrosis/AQP2 accumulation, glucose clamp with surface GLUT4 imaging, Co-IP of syntaxin 3/4

    PMID:19841070 PMID:20876717

    Open questions at the time
    • Directionality (exocytic vs endocytic) mechanism across tissues unclear
    • Whether the same SNARE complexes operate in endocytosis not established
  9. 2013 High

    Revealed a non-canonical VAMP8 function in delivering the NOX2 oxidase to phagosomes/endosomes for ROS production and cross-presentation, and showed pathogens cleave VAMP8 to subvert this.

    Evidence GP63 biochemical cleavage of VAMP8, Vamp8 KO cells with NOX2 assembly, phagosomal pH, cross-presentation and T cell activation assays; siRNA in dendritic cells

    PMID:23870310 PMID:28688576

    Open questions at the time
    • Direct SNARE-independent vs fusion-dependent contribution to NOX2 delivery unresolved
    • Mechanism of NOX2 vesicle recruitment by VAMP8 unknown
  10. 2015 Medium

    Resolved post-translational and trafficking control of the autophagic VAMP8 pool, linking starvation signaling to lysosomal VAMP8 delivery.

    Evidence Sbf/MTMR13-RAB21 GEF and Co-IP assays in Drosophila and mammalian cells with autophagy flux readouts; sequential recycling-endosome fusion in CTLs by TIRF imaging

    PMID:25648148 PMID:26124288

    Open questions at the time
    • Single-lab findings without reconstitution of the trafficking step
    • How RAB21 binding alters VAMP8 sorting structurally unknown
  11. 2021 High

    Defined mTORC1 phosphorylation as a master switch that inhibits STX17-SNAP29-VAMP8 assembly, with SCFD1 and prefusion lysosome clustering tuning stimulated autophagic fusion.

    Evidence In vitro mTORC1 kinase assay, phosphomimic VAMP8 in reconstituted fusion and lipid-mixing assays, SCFD1 localization, SIM imaging, in vivo liver lipid phenotype

    PMID:34645799 PMID:34785650

    Open questions at the time
    • Phosphatase reversing VAMP8 phosphorylation not identified
    • Phosphosite-resolved structural mechanism of inhibited assembly incomplete
  12. 2024 High

    Established a stabilization circuit in which DRAM1 protects lysosomal VAMP8 from CHIP-mediated ubiquitination to promote autophagic SNARE assembly, complementing transcriptional control by NRF2, CREB/CENPN, and modification of SNAP29.

    Evidence Co-IP, complex assembly and ubiquitination assays with Lys68/72/75 mutagenesis and CHIP competition; NRF2-KO and CENPN ChIP/knockdown studies; O-GlcNAc SNAP29 Co-IP

    PMID:30221662 PMID:36724221 PMID:37776538 PMID:40595569

    Open questions at the time
    • Integration of these parallel regulatory inputs in vivo not resolved
    • Deubiquitinase counteracting CHIP not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • How VAMP8 is partitioned and selectively recruited among its many membrane compartments (late endosomes, autophagosomes, and diverse secretory granules) to assemble the correct combinatorial SNARE complex remains unresolved.
  • No structural model of compartment-specific complex selection
  • Sorting determinants directing VAMP8 to distinct granule types unknown
  • Coordination of phosphorylation, ubiquitination, and trafficking inputs in a single cell not integrated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 4 GO:0008289 lipid binding 1
Localization
GO:0031410 cytoplasmic vesicle 7 GO:0005764 lysosome 4 GO:0005768 endosome 3 GO:0005886 plasma membrane 3
Pathway
R-HSA-5653656 Vesicle-mediated transport 5 R-HSA-168256 Immune System 4 R-HSA-9609507 Protein localization 4 R-HSA-9612973 Autophagy 4 R-HSA-109582 Hemostasis 3
Partners
SCFD1SNAP23SNAP29STX17STX4STX7STX8VTI1B
Complex memberships
STX17-SNAP29-VAMP8 SNARE complexsyntaxin 4/SNAP-23/VAMP8 exocytic SNARE complexsyntaxin 7/Vti1b/syntaxin 8/VAMP8 late-endosome SNARE complex

Evidence

Reading pass · 42 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 Syntaxin 7 localizes to late endosomes/lysosomes and associates with VAMP8 (Vamp 8) by co-immunoprecipitation; syntaxin 7 is specifically required for fusion of late endosomes with lysosomes in vitro, identifying a SNARE complex (syntaxin 7 / VAMP8) that functions in the late endocytic pathway. Co-immunoprecipitation, cell-free in vitro fusion assay, immunolocalization Molecular biology of the cell High 10982406
2001 In B16 melanoma cells, immunoaffinity purification of syntaxin 7 co-isolated VAMP8 and VAMP7 among other SNARE partners (syntaxin 6, mVti1b, αSNAP), suggesting that syntaxin 7/mVti1b/syntaxin 6 can form discrete complexes with either VAMP7 or VAMP8 to regulate late endosomal fusion events. Large-scale immunoaffinity purification, electrospray mass spectrometry, immunoblotting, co-immunoprecipitation, confocal colocalization The Journal of biological chemistry Medium 11278762
2004 In antibody-inhibition experiments using rat liver cell-free systems, the Q-SNARE complex of syntaxin 7/Vti1b/syntaxin 8 plus VAMP8 mediates homotypic late-endosome fusion, while the same Q-SNAREs combine with VAMP7 for heterotypic late-endosome–lysosome fusion; separate co-immunoprecipitation confirmed distinct syntaxin 7 complexes with VAMP7 vs. VAMP8 in solubilized liver membranes. Antibody inhibition in cell-free fusion assay, co-immunoprecipitation, overexpression of VAMP7 N-terminal domain to inhibit heterotypic fusion EMBO reports High 15133481
2004 VAMP8 is enriched on zymogen granule membranes in pancreatic acinar cells and forms a SNARE complex with syntaxin 4 and SNAP-23. VAMP8-knockout mice accumulate zymogen granules (~3-fold) and show abolished secretagogue-stimulated exocytosis from acinar cells, establishing VAMP8 as the major v-SNARE for regulated exocytosis in exocrine pancreas. Targeted gene knockout in mice, immunohistochemistry, co-immunoprecipitation, secretion assay from pancreatic fragments Developmental cell High 15363411
2006 VAMP8 (endobrevin) is the primary v-SNARE for platelet dense-core granule, alpha-granule, and lysosome release; VAMP8-/- mouse platelets show significant agonist-induced secretion defects, while VAMP-2+/-, VAMP-3-/-, and VAMP-2+/-/VAMP-3-/- platelets show no defect. Tetanus toxin (cleaving VAMP-2/-3) blocks residual release in VAMP-8-/- platelets, revealing a secondary role for VAMP-2/-3. Genetic knockout (VAMP-8-/-, VAMP-2+/-, VAMP-3-/-) platelet secretion assays, tetanus toxin treatment of permeabilized platelets Molecular biology of the cell High 17065550
2002 VAMP-3 and VAMP-8 (but not VAMP-1 or VAMP-2) are identified in human platelets by mass spectrometry co-immunoprecipitated with syntaxin 4; recombinant VAMP-8 added to permeabilized platelets inhibits dense-granule secretion but not alpha-granule secretion, while rVAMP-3 inhibits both, demonstrating isoform-specific roles in platelet exocytosis. Nano-ESI tandem MS, immunoblotting, co-immunoprecipitation with syntaxin 4, competitive inhibition assay with recombinant VAMPs in permeabilized platelets Blood High 12130530
2007 VAMP8 is expressed in all examined exocrine tissues (salivary, lacrimal, sweat, sebaceous, mammary glands, prostate). VAMP8-null mice show severe secretory granule accumulation and impaired pilocarpine-stimulated secretion in salivary and lacrimal glands; VAMP8 co-immunoprecipitates with syntaxin 4 and SNAP-23, establishing it as a general v-SNARE for regulated exocrine secretion. VAMP8-null mouse phenotyping, immunohistochemistry, electron microscopy, stimulated secretion assay, co-immunoprecipitation Molecular biology of the cell High 17215514
2007 In permeabilized rat basophilic leukaemia cells, recombinant VAMP8/endobrevin (but not other R-SNAREs tested) specifically blocks hexosaminidase exocytosis; this secretion is insensitive to clostridial neurotoxins, consistent with VAMP8 serving as the primary R-SNARE for mast cell granule exocytosis. Permeabilized cell exocytosis inhibition assay with complete set of recombinant mammalian R-SNAREs, hexosaminidase release assay, clostridial neurotoxin treatment FEBS letters High 17618625
2008 In bone marrow-derived mast cells, VAMP-8 co-localizes with secretory granules and redistributes upon stimulation, forming increased SNARE complexes with SNAP-23 and syntaxin-4. VAMP-8-deficient BMMCs show markedly reduced degranulation after IgE/antigen, thapsigargin, or ionomycin stimulation; plasma histamine is reduced in passive systemic anaphylaxis in VAMP-8-/- mice. Cytokine/chemokine release is not affected, while unprocessed TNF accumulates at the plasma membrane in a VAMP-3-positive compartment, demonstrating that VAMP-8 segregates granule exocytosis from cytokine trafficking. VAMP-8 KO mice, bone marrow-derived mast cell degranulation assays, confocal microscopy, SNARE complex immunoprecipitation, passive systemic anaphylaxis model Blood High 18203950
2008 VAMP8 is the zymogen granule SNARE mediating basolateral exocytosis in alcoholic pancreatitis; ethanol exposure redirects apical to basolateral exocytosis in WT acini, but VAMP8-/- mice show blockade of both apical and basolateral exocytosis. Electron microscopy revealed reduced ZG-ZG homotypic fusions in VAMP8-/- acinar cells, establishing VAMP8 as critical for ZG-ZG fusion and basolateral secretion. VAMP8-/- mice, in vitro ethanol exposure + carbachol stimulation, amylase secretion assay, electron microscopy of ZG-ZG fusions The Journal of clinical investigation High 18535671
2008 In mature human intestinal mast cells, VAMP-7 and VAMP-8 translocate to the plasma membrane and interact with SNAP-23 and STX-4 upon activation; inhibition of VAMP-7 or VAMP-8 (but not VAMP-2 or VAMP-3) markedly reduces IgE receptor-mediated histamine release, defining VAMP-7 and VAMP-8 as the required v-SNAREs for human mast cell degranulation. Primary human mast cell isolation, VAMP peptide inhibition, SNAP-23/STX-4 co-immunoprecipitation, histamine release assay European journal of immunology Medium 18253931
2009 VAMP8 is localized to CTL lytic granules; VAMP8-/- CTL show normal immunological synapse formation and granule polarization but significantly reduced granzyme A and granzyme B secretion, establishing VAMP8 as a v-SNARE required for lytic granule fusion with the plasma membrane during CTL-mediated killing. VAMP8-/- mice, CTL cytotoxicity assay, granzyme secretion assay, immunofluorescence colocalization European journal of immunology High 19830729
2009 VAMP8 localizes to secretory granules in macrophages and mediates TNF-alpha release; TNF-alpha co-localizes with VAMP8-positive vesicles in WT macrophages, while VAMP8-/- macrophages show inhibited TNF-alpha secretion and reduced degranulation. VAMP8-/- mice are protected from C5a-induced neutropenia, peritonitis, and systemic inflammation. VAMP8-/- mice, macrophage degranulation assay, TNF-alpha ELISA, confocal colocalization, in vivo peritonitis model Journal of immunology High 19564343
2010 VAMP8 depletion in mice causes hydronephrosis and a 3–5-fold increase in aquaporin 2 (AQP2) levels; vasopressin/forskolin-induced AQP2 exocytosis is impaired in VAMP8-null collecting duct cells. VAMP8 co-localizes with AQP2 on intracellular vesicles and interacts with syntaxin 4 and syntaxin 3 t-SNAREs, establishing a role in regulated AQP2 trafficking to the plasma membrane. VAMP8-null mice, immunofluorescence colocalization, exocytosis assay in collecting duct cells, co-immunoprecipitation Molecular and cellular biology High 19841070
2010 Knockdown of Vti1b and VAMP8 with siRNA disturbs autophagosome-lysosome fusion (LC3/LAMP1 colocalization reduced) without affecting bacterial invasion efficiency, but impairs cellular bactericidal efficiency in xenophagy (Group A Streptococcus). The same SNARE pair (VAMP8 + Vti1b) is required for canonical autophagosome-lysosome fusion; knockdown of syntaxin 7 or syntaxin 8 had little effect on autophagic fusion. siRNA knockdown, confocal microscopy for LC3/LAMP1 colocalization, bacterial survival assay, canonical autophagy LC3-II degradation assay Molecular biology of the cell High 20089838
2010 In VAMP8-null mice, sarcolemmal GLUT4 levels are increased in both basal and insulin-stimulated states without change in total GLUT4, indicating VAMP8 is required for endocytosis of the insulin-responsive GLUT4 transporter. VAMP8-null mice display fasting hypoglycemia, enhanced glucose tolerance, and increased skeletal muscle glucose uptake. VAMP8-null mice, euglycemic-hyperinsulinemic clamp with radiotracer glucose uptake, immunofluorescence microscopy for sarcolemmal GLUT4 Diabetes High 20876717
2010 Vti1b-deficient and Vamp8-deficient CTL show significantly reduced degranulation (CD107a surface exposure) and ~50% reduced cytotoxic activity after 3 days of antigen-specific stimulation; by day 4, cytotoxic activity is no longer impaired, suggesting a compensable role for both SNARE proteins in lytic granule exocytosis during early CTL development. Vti1b-KO and Vamp8-KO TCR-transgenic OT-I mice, CD107a degranulation assay, cytolytic activity assay Journal of immunology Medium 20543108
2011 VAMP8 is specifically required for sequential (granule-to-granule) compound exocytosis in pancreatic acinar cells. Using an assay distinguishing primary (granule-plasma membrane) from secondary (granule-granule) fusion events, VAMP8-KO acinar cells show specific reduction in secondary granule fusion but not primary fusion. Immunoprecipitation shows syntaxin 3 associates with VAMP8 for granule-granule fusion, while syntaxin 2 associates with VAMP2 for primary fusion. VAMP8-KO mice, two-photon live-cell imaging distinguishing primary vs. secondary fusion events, immunoprecipitation The Journal of biological chemistry High 21733851
2011 VAMP8 localizes predominantly to goblet cell mucin granules in human airway epithelium; siRNA/shRNA knockdown of VAMP8 reduces mucin secretion stimulated by PAR agonists, neutrophil elastase, and ATP, as well as basal secretion. VAMP8-KO mice with IL-13-induced mucous metaplasia show reduced mucin in bronchoalveolar lavage. Knockdown of VAMP2 or VAMP3 does not affect mucin secretion. VAMP8 siRNA/shRNA knockdown in airway epithelial cell cultures, mucin secretion assay, VAMP8-KO mice with mucous metaplasia model, immunolocalization The Journal of physiology High 22144578
2012 VAMP8-null mice show impaired insulin granule recruitment to the plasma membrane contributing to reduced GLP-1 potentiation of glucose-stimulated insulin secretion; however, VAMP8-null mice also display increased islet β cell mass from enhanced β cell mitosis, amplified by GLP-1, demonstrating a dual role of VAMP8 in insulin granule exocytosis and islet β cell growth. VAMP8-null mice, glucose-stimulated insulin secretion assay, islet morphometry, β cell proliferation assay, GLP-1 treatment Cell metabolism High 22841572
2013 The Leishmania surface metalloprotease GP63 cleaves VAMP8 (among other SNAREs) on phagosomes. GP63-mediated VAMP8 inactivation (or Vamp8 gene disruption) prevents NADPH oxidase (NOX2) complex assembly on phagosomes, altering phagosomal pH and degradative properties, and inhibiting MHC class I cross-presentation of Leishmania antigens, thereby reducing T cell activation. GP63 cleavage of VAMP8 (biochemical), Vamp8 KO cells/mice, phagosomal NOX2 assembly assay, phagosomal pH measurement, MHC class I cross-presentation assay, T cell activation assay Cell host & microbe High 23870310
2015 In primary human CTLs, VAMP8 co-localizes with Rab11a-positive recycling endosomes (not cytotoxic granules). Upon stimulation, VAMP8-positive recycling endosomes traffic to and fuse with the plasma membrane at immune synapses before cytotoxic granule fusion. VAMP8 knockdown blocks both recycling endosome and cytotoxic granule fusion. Mechanistically, VAMP8-dependent recycling endosome fusion deposits syntaxin-11 at immune synapses to facilitate assembly of plasma membrane SNARE complexes required for cytotoxic granule exocytosis. Confocal and TIRF microscopy in primary human CTLs, VAMP8 siRNA knockdown, live-cell imaging of vesicle fusion kinetics, syntaxin-11 localization assay The Journal of cell biology High 26124288
2015 Starvation induces Sbf/MTMR13 GEF activity and RAB21 activation, which promotes MTMR13 and RAB21 binding to VAMP8, facilitating endolysosomal trafficking of VAMP8 to lysosomes required for autophagosome-lysosome fusion. Depletion of Sbf/MTMR13 or Rab21 blocks VAMP8 endolysosomal delivery and impairs starvation-induced autophagy. Drosophila and mammalian cell depletion experiments, Rab21 GEF activity assay, co-immunoprecipitation of MTMR13/RAB21 with VAMP8, autophagy flux assay, endolysosomal trafficking assay EMBO reports Medium 25648148
2017 VAMP8 mediates NOX2 trafficking not only to phagosomes but also to endosomes in both human and mouse dendritic cells. Absence of VAMP8 leads to decreased ROS production, reduced lipid peroxidation, impaired antigen translocation to cytosol, and impaired cross-presentation; VAMP8 knockdown did not affect MHC class I or TAP1 recruitment to phagosomes. VAMP8 knockdown in human and mouse DCs, NOX2 recruitment assay, ROS measurement, lipid peroxidation assay, antigen translocation and cross-presentation assay European journal of cell biology Medium 28688576
2017 APOL1 protein interacts with VAMP8 in podocytes; this interaction was confirmed by co-immunoprecipitation and surface plasmon resonance. APOL1 disease-associated variants attenuate this interaction. Molecular dynamics simulations and circular dichroism spectroscopy reveal that variant APOL1 has increased C-terminal conformational stability (a more closed/autoinhibited state), reducing interaction with VAMP8-coated vesicles. Co-immunoprecipitation, surface plasmon resonance, molecular dynamics simulation, circular dichroism spectroscopy, structural homology search JCI insight Medium 28724794
2017 VAMP8 is present on mucin granules in intestinal goblet cells and is specifically activated during Entamoeba histolytica infection to coordinate mucin exocytosis; ablation of VAMP8 impairs mucin secretion, increases E. histolytica adherence and epithelial cell apoptosis, and triggers a proinflammatory response (IL-1α, IL-1β, TNF-α). VAMP8 siRNA knockdown in human goblet cells, Vamp8-/- mice, E. histolytica infection model, mucin secretion assay, apoptosis assay, cytokine measurement mBio High 28974617
2017 VAMP8 knockdown reduced JAK1 and STAT1 phosphorylation and impaired induction of interferon-stimulated genes (ISGs) following West Nile virus infection or IFN-β treatment; VAMP8-mediated STAT1 phosphorylation required presence of TRIM6, identifying VAMP8 as a novel regulator of type I interferon signaling downstream of TRIM6. VAMP8 siRNA knockdown in human cells, phospho-JAK1/STAT1 western blotting, ISG induction assay, next-generation sequencing identification of VAMP8 Journal of virology Medium 31694946
2018 VAMP8 interacts with the metastasis suppressor GTPase RAB37; confocal and TIRF microscopy show VAMP8 co-localizes with RAB37 and facilitates trafficking of RAB37-TIMP1 vesicles. VAMP8 is required for RAB37-regulated exocytosis of TIMP1 to suppress lung cancer metastasis, demonstrated by tail-vein injection reconstitution experiments. Co-immunoprecipitation, confocal and TIRF microscopy, exocytosis/secretion assay for TIMP1, tail-vein injection metastasis model, lung-to-lung metastasis reconstitution Cancer letters Medium 30165196
2019 VAMP8 coordinates MUC2 mucin exocytosis from colonic goblet cells; Vamp8-/- mice exhibit altered mucus layer, increased encounters with microbial antigens, shift to detrimental microbiota, mild basal pro-inflammatory state, and high susceptibility to chemical and infectious colitis, demonstrating essential role of VAMP8 in intestinal homeostasis via mucus exocytosis. Vamp8-/- mice, mucin secretion assay, intestinal microbiota analysis, colitis models (chemical and infectious), immunology assays Nature communications High 31541089
2019 Defective AP-3-dependent trafficking in Hermansky-Pudlak Syndrome type 2 (HPS2) endothelial cells depletes VAMP8 from Weibel-Palade bodies; CRISPR-Cas9-engineered VAMP8-/- endothelial cells show impaired stimulus-induced von Willebrand factor secretion, establishing VAMP8 as an AP-3-dependent SNARE required for Weibel-Palade body exocytosis. Patient-derived blood outgrowth endothelial cells, CRISPR-Cas9 KO of VAMP8, proteome analysis, von Willebrand factor secretion assay Haematologica High 30630984
2021 mTORC1 directly phosphorylates VAMP8, inhibiting formation of the STX17-SNAP29-VAMP8 SNARE complex and thereby blocking autophagosome-lysosome fusion. A VAMP8 phosphorylation mimic mutant fails to promote autophagosome-lysosome fusion in vitro. Dephosphorylated VAMP8 promotes recruitment of SCFD1 (Sec1/Munc18-like protein) to autolysosomes; phosphorylated VAMP8 or SCFD1 depletion inhibits fusion. Expression of phosphomimic VAMP8 in mouse liver increases lipid droplet accumulation. mTORC1 kinase assay (phosphorylation), in vitro fusion assay with phosphomimic VAMP8, SCFD1 localization assay, Co-IP for SNARE complex, liver lipid droplet assay Nature communications High 34785650
2021 VAMP8 on lysosomes assists in forming prefusion clusters of multiple lysosomes around individual autophagosomes upon stimulation. A VAMP8 phosphorylation mimic reduces fusion in a lipid-mixing ensemble assay and increases unfused lysosomes associated with autophagosomes, suggesting phosphorylation minimizes spontaneous autophagosome-lysosome fusion under normal conditions while pre-assembling lysosomes for stimulated autophagy. Structured illumination microscopy, ensemble lipid-mixing fusion assay, VAMP8 phosphorylation mimic mutation Cell death & disease Medium 34645799
2023 NRF2 transcriptionally maintains VAMP8 expression; NRF2-knockout cells have low VAMP8, which blocks autophagosome-lysosome fusion (ferritinophagy), leading to apoferritin accumulation in autophagosomes and an elevated labile iron pool, enhancing sensitivity to ferroptosis. NRF2 knockout cells, VAMP8 protein/mRNA measurement, LC3/LAMP1 colocalization assay, ferritin/NCOA4 immunoblotting, ferroptosis assay Science advances Medium 36724221
2024 DRAM1 physically interacts with VAMP8 on lysosomes; this interaction is enhanced upon autophagy stimulation. DRAM1 preferentially promotes autophagosome-lysosome fusion by enhancing assembly of the STX17-SNAP29-VAMP8 complex. DRAM1 stabilizes lysosomal VAMP8 by inhibiting CHIP-mediated ubiquitination of VAMP8 at Lys68, 72, and 75, competitively binding CHIP. Co-immunoprecipitation, STX17-SNAP29-VAMP8 complex assembly assay, ubiquitination assay, CHIP-VAMP8 binding competition, site-directed mutagenesis of Lys68/72/75, autophagy flux assay Nature communications High 40595569
2007 Salmonella SopB-generated PtdIns(3)P directly binds VAMP8/endobrevin and recruits it to Salmonella-induced macropinosomes in a nocodazole-dependent, Brefeldin A-independent manner; knockdown of VAMP8 or expression of truncated VAMP8 (1-79aa) reduces Salmonella invasion efficiency to the level of SopB phosphatase-dead mutant, demonstrating that bacteria exploit VAMP8 and PtdIns(3)P binding to promote phagocytosis. PtdIns(3)P–VAMP8 direct binding assay, VAMP8 siRNA knockdown, confocal colocalization, pharmacological inhibitors (wortmannin, nocodazole, Brefeldin A), bacterial invasion assay Traffic Medium 17645435
2014 VAMP8-mediated ZG exocytosis depends on constitutive-like secretory pathway via early endosomal proteins Rab5/D52/EEA1; VAMP8-/- acini show >90% decrease in Rab5/D52/EEA1 and increased Rab11a/TI-VAMP7 on ZGs. GDP-trapped Rab11a-S25N specifically inhibits the VAMP8 but not VAMP2 secretion pathway; rescue of Rab5/D52/EEA1 expression restores VAMP8-dependent secretion. VAMP8-/- acini, Rab11a dominant-negative expression, adenoviral D52/Rab5 rescue, perifusion secretion kinetics assay, confocal colocalization The Journal of biological chemistry High 25138214
2018 O-GlcNAc modification of SNAP29 inhibits formation of the SNAP29-STX17-VAMP8 SNARE complex; co-immunoprecipitation in diabetic rat cardiomyocytes showed that increased O-GlcNAc-SNAP29 disrupts STX17-VAMP8 complex assembly, blocking autophagic flux and exacerbating myocardial injury. Co-immunoprecipitation of SNAP29-STX17-VAMP8 complex, O-GlcNAc modification assay, STZ diabetic rat model, thiamet G and DON pharmacological tools, autophagy flux assay International journal of molecular medicine Medium 30221662
2009 In dendritic cells, caspases regulate VAMP-8 expression; VAMP-8 protein is a substrate of caspases, and treatment with caspase inhibitor upregulates VAMP-8. Consistent with VAMP-8's role in inhibiting phagocytosis in DCs, immature DCs treated with caspase inhibitor show lower phagocytosis activity. Caspase inhibitor treatment, VAMP-8 expression analysis, phagocytosis assay, identification of caspase cleavage sites on VAMP-8 Biochemical and biophysical research communications Low 19607812
2020 VAMP8 overexpression in neuronal cells (N2a) significantly increases tau secretion via late endosome-plasma membrane fusion, reducing intracellular tau levels; TIRF microscopy shows fusion of VAMP8-positive vesicles with plasma membrane correlates with cytoplasmic tau depletion. VAMP8 overexpression also reduces intracellular α-synuclein by increasing secretion. VAMP8 overexpression in N2a cells and murine hippocampal slices, intracellular/extracellular tau quantification, TIRF microscopy of VAMP8-positive vesicle fusion The Journal of biological chemistry Medium 33454017
2022 Oxidative stress inhibits endocytosis, decreasing lysosomal localization of VAMP8 and blocking autophagosome-lysosome fusion in human neuroblastoma cells; treatment with an endocytosis inhibitor recapitulates the VAMP8 lysosomal depletion and autophagy block, establishing that endocytic trafficking is required for VAMP8 delivery to lysosomes for autophagy. Oxidative stress induction, endocytosis inhibitor treatment, lysosomal VAMP8 localization assay (immunofluorescence), autophagosome-lysosome fusion assay Biological & pharmaceutical bulletin Low 36328496
2023 CENPN inhibits VAMP8 transcription by reducing phospho-CREB binding to the VAMP8 promoter; CENPN knockdown increases p-CREB nuclear translocation and VAMP8 expression, enhancing autophagic flux and paclitaxel sensitivity in nasopharyngeal carcinoma. Sequential knockdown of CENPN and VAMP8 reverses the PTX-sensitizing effect of CENPN knockdown, confirming VAMP8 as the mediator. ChIP assay for p-CREB binding to VAMP8 promoter, siRNA/shRNA knockdown, autophagy flux assay, nude mouse xenograft PTX sensitivity assay Autophagy Medium 37776538
2023 VAMP8 interacts with DDX5 in osteosarcoma cells; this interaction promotes DDX5 degradation via the ubiquitin-proteasome system, reducing β-catenin levels and suppressing EMT and metastasis. VAMP8 also promotes autophagy flux as a potential additional metastasis-suppressive mechanism. Co-immunoprecipitation of VAMP8-DDX5, ubiquitin-proteasome inhibitor experiments, β-catenin expression, EMT marker analysis, invasion/migration assays Cancer biology & therapy Low 37405957

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2023 NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8. Science advances 423 36724221
1994 The fibronectin isoform containing the ED-B oncofetal domain: a marker of angiogenesis. International journal of cancer 278 7525495
2004 Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events. EMBO reports 219 15133481
2001 Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice. Cancer research 191 11212273
2010 Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. Molecular biology of the cell 178 20089838
2009 VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA. Journal of thrombosis and haemostasis : JTH 155 19943878
2004 A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells. Developmental cell 139 15363411
2006 Endobrevin/VAMP-8 is the primary v-SNARE for the platelet release reaction. Molecular biology of the cell 133 17065550
2000 Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion. Molecular biology of the cell 131 10982406
2008 VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways. Blood 130 18203950
2013 Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8. Cell host & microbe 119 23870310
1992 The inclusion of the type III repeat ED-B in the fibronectin molecule generates conformational modifications that unmask a cryptic sequence. The Journal of biological chemistry 119 1280266
2002 Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. Blood 118 12130530
2005 ED-B fibronectin as a target for antibody-based cancer treatments. Expert opinion on therapeutic targets 86 15948669
2008 Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. European journal of immunology 85 18253931
2002 Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro. Cancer research 85 12359774
2008 VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis. The Journal of clinical investigation 83 18535671
2005 EDB fibronectin and angiogenesis -- a novel mechanistic pathway. Angiogenesis 83 16308732
2007 VAMP8/endobrevin as a general vesicular SNARE for regulated exocytosis of the exocrine system. Molecular biology of the cell 82 17215514
2019 VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis. Nature communications 77 31541089
2015 Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. EMBO reports 76 25648148
2015 EDB Fibronectin Specific Peptide for Prostate Cancer Targeting. Bioconjugate chemistry 74 25848940
2015 VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity. The Journal of cell biology 72 26124288
2001 Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. The Journal of biological chemistry 72 11278762
2012 Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth. Cell metabolism 71 22841572
2011 Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion. The Journal of biological chemistry 70 21733851
2006 Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction. Arteriosclerosis, thrombosis, and vascular biology 62 16690874
1996 Expression of fibronectin ED-A+ and ED-B+ isoforms by human and experimental colorectal cancer. Contribution of cancer cells and tumor-associated myofibroblasts. The American journal of pathology 61 8579120
2021 mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation. Nature communications 60 34785650
1993 Coordinate oncodevelopmental modulation of alternative splicing of fibronectin pre-messenger RNA at ED-A, ED-B, and CS1 regions in human liver tumors. Cancer research 59 8481903
1999 NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis. Structure (London, England : 1993) 54 10196121
2017 APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8. JCI insight 53 28724794
2014 VAMP8 facilitates cellular proliferation and temozolomide resistance in human glioma cells. Neuro-oncology 53 25209430
2006 huBC1-IL12, an immunocytokine which targets EDB-containing oncofetal fibronectin in tumors and tumor vasculature, shows potent anti-tumor activity in human tumor models. Cancer immunology, immunotherapy : CII 51 16874486
2007 Small-animal PET of tumor angiogenesis using a (76)Br-labeled human recombinant antibody fragment to the ED-B domain of fibronectin. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 50 17574989
2021 Prefused lysosomes cluster on autophagosomes regulated by VAMP8. Cell death & disease 49 34645799
1990 Expression of tenascin and of the ED-B containing oncofetal fibronectin isoform in human cancer. Cell differentiation and development : the official journal of the International Society of Developmental Biologists 47 1711919
2011 VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells. The Journal of physiology 45 22144578
2010 The exocytosis of lytic granules is impaired in Vti1b- or Vamp8-deficient CTL leading to a reduced cytotoxic activity following antigen-specific activation. Journal of immunology (Baltimore, Md. : 1950) 45 20543108
1992 Differential expression of the fibronectin isoform containing the ED-B oncofetal domain in normal human fibroblast cell lines originating from different tissues. Experimental cell research 43 1310473
2007 Endobrevin/VAMP8 mediates exocytotic release of hexosaminidase from rat basophilic leukaemia cells. FEBS letters 42 17618625
1998 Evidence of ED-B+ fibronectin synthesis in human tissues by non-radioactive RNA in situ hybridization. Investigations on carcinoma (oral squamous cell and breast carcinoma), chronic inflammation (rheumatoid synovitis) and fibromatosis (Morbus Dupuytren). Histochemistry and cell biology 42 9541473
2018 O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats. International journal of molecular medicine 41 30221662
2007 Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis. Traffic (Copenhagen, Denmark) 40 17645435
2020 Antitumor Effects of CAR T Cells Redirected to the EDB Splice Variant of Fibronectin. Cancer immunology research 39 33355188
2017 VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release. European journal of cell biology 39 28688576
1994 Myofibroblast and concurrent ED-B fibronectin phenotype in human stromal cells cultured from non-malignant and malignant breast tissue. European journal of cancer (Oxford, England : 1990) 39 8142168
2009 A role for endobrevin/VAMP8 in CTL lytic granule exocytosis. European journal of immunology 35 19830729
2020 VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection. Journal of virology 34 31694946
2017 ED-B fibronectin expression is a marker of epithelial-mesenchymal transition in translational oncology. Oncotarget 34 27902486
2017 Entamoeba histolytica-Induced Mucin Exocytosis Is Mediated by VAMP8 and Is Critical in Mucosal Innate Host Defense. mBio 31 28974617
2005 ED-B fibronectin in non-small cell lung carcinoma. Experimental lung research 31 16203624
2019 Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells. Haematologica 30 30630984
2007 ED-B fibronectin (ED-B) can be targeted using a novel single chain antibody conjugate and is associated with macrophage accumulation in atherosclerotic lesions. Basic research in cardiology 30 17468934
2001 Production of functionalized single-chain Fv antibody fragments binding to the ED-B domain of the B-isoform of fibronectin in Pichia pastoris. Protein expression and purification 30 11162401
1999 Expression of EDA/EDB isoforms of fibronectin in papillary carcinoma of the thyroid. The Journal of pathology 30 10398159
2010 A role for VAMP8/endobrevin in surface deployment of the water channel aquaporin 2. Molecular and cellular biology 29 19841070
1995 Alternative splicing of ED-A and ED-B sequences of fibronectin pre-mRNA differs in chondrocytes from different cartilaginous tissues and can be modulated by biological factors. The Journal of biological chemistry 29 7829518
2015 Identification and characterization of a unique role for EDB fibronectin in phagocytosis. Journal of molecular medicine (Berlin, Germany) 28 26637426
2011 KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. Atherosclerosis 28 22192511
2010 Enhanced energy expenditure, glucose utilization, and insulin sensitivity in VAMP8 null mice. Diabetes 28 20876717
1988 Sequence analysis and in vivo expression show that alternative splicing of ED-B and ED-A regions of the human fibronectin gene are independent events. Nucleic acids research 26 3375063
2024 CENPN suppresses autophagy and increases paclitaxel resistance in nasopharyngeal carcinoma cells by inhibiting the CREB-VAMP8 signaling axis. Autophagy 24 37776538
2015 Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB. Advanced healthcare materials 24 26097122
2004 Expression of EDA+ and EDB+ fibronectin splice variants in bone. Bone 24 15589214
1996 Adhesion mediated by fibronectin's alternatively spliced EDb (EIIIB) and its neighboring type III repeats. Experimental cell research 24 8635499
1994 Distribution of ED-A and ED-B containing fibronectin isoforms in Dupuytren's disease. The Journal of hand surgery 24 8056970
2006 Evidence for a differential expression of fibronectin splice forms ED-A and ED-B in Crohn's disease (CD) mucosa. International journal of colorectal disease 23 17136547
2018 VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function. Cancer letters 22 30165196
2020 Long non-coding RNA LINC01426 facilitates glioblastoma progression via sponging miR-345-3p and upregulation of VAMP8. Cancer cell international 21 32699526
2014 Vesicle associated membrane protein 8 (VAMP8)-mediated zymogen granule exocytosis is dependent on endosomal trafficking via the constitutive-like secretory pathway. The Journal of biological chemistry 21 25138214
2005 Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells. Histochemistry and cell biology 20 16195891
2019 Effective MR Molecular Imaging of Triple Negative Breast Cancer With an EDB-Fibronectin-Specific Contrast Agent at Reduced Doses. Frontiers in oncology 19 31850230
1999 Increased Ed-B fibronectin plasma levels in spondyloarthropathies: comparison with rheumatoid arthritis patients and a healthy population. Rheumatology (Oxford, England) 19 10556262
2017 Acute acinar pancreatitis blocks vesicle-associated membrane protein 8 (VAMP8)-dependent secretion, resulting in intracellular trypsin accumulation. The Journal of biological chemistry 18 28242757
2012 Molecular control of compound Exocytosis: A key role for VAMP8. Communicative & integrative biology 18 22482012
2009 VAMP8 is essential in anaphylatoxin-induced degranulation, TNF-alpha secretion, peritonitis, and systemic inflammation. Journal of immunology (Baltimore, Md. : 1950) 18 19564343
1998 Interstitial collagenase and the ED-B oncofetal domain of fibronectin are markers of angiogenesis in human skin tumors. Cancer detection and prevention 18 9727625
2020 Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion. The Journal of biological chemistry 16 33454017
2009 Caspases regulate VAMP-8 expression and phagocytosis in dendritic cells. Biochemical and biophysical research communications 16 19607812
2015 Shiga toxin stimulates clathrin-independent endocytosis of the VAMP2, VAMP3 and VAMP8 SNARE proteins. Journal of cell science 15 26071526
2000 The angiogenesis marker ED-B+ fibronectin isoform in intracranial meningiomas. Acta neurochirurgica 15 10819258
2022 VAMP8 phosphorylation regulates lysosome dynamics during autophagy. Autophagy reports 14 35498374
2017 EDB Fibronectin-Specific SPECT Probe 99mTc-HYNIC-ZD2 for Breast Cancer Detection. ACS omega 13 30023665
1999 Characterization of the expression of the alternative splicing of the ED-A, ED-B and V regions of fibronectin mRNA in bovine ovarian follicles and corpora lutea. Reproduction, fertility, and development 13 10972305
1997 Loss of EDB+ fibronectin isoform is associated with differentiation of alveolar epithelial cells in human fetal lung. The American journal of pathology 13 9250153
2019 EDB-FN Targeted Peptide-Drug Conjugates for Use against Prostate Cancer. International journal of molecular sciences 12 31277465
2009 Impact of VEGF-dependent tumour micro-environment on EDB fibronectin expression by subcutaneous human tumour xenografts in nude mice. The Journal of pathology 12 19824060
2023 Inhibition of STX17-SNAP29-VAMP8 complex formation by costunolide sensitizes ovarian cancer cells to cisplatin via the AMPK/mTOR signaling pathway. Biochemical pharmacology 11 37060961
2017 Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease. Journal of ophthalmology 11 29098081
2008 Thymic alterations in mice deficient for the SNARE protein VAMP8/endobrevin. Cell and tissue research 10 18923845
1998 Carcinogenic effects of 1,2-dibromoethane (ethylene dibromide; EDB) in Japanese medaka (Oryzias latipes). Mutation research 10 9672661
2018 In situ bioremediation of 1,2-dibromoethane (EDB) in groundwater to part-per-trillion concentrations using cometabolism. Journal of contaminant hydrology 9 30293921
2025 DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation. Nature communications 8 40595569
2023 VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma. Cancer biology & therapy 8 37405957
2022 EDB Gene Cluster-Dependent Indole Production Is Responsible for the Ability of Pseudomonas fluorescens NZI7 to Repel Grazing by Caenorhabditis elegans. Journal of natural products 8 35077157
2022 Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8. Biological & pharmaceutical bulletin 8 36328496
2020 Association of KLK3, VAMP8 and MDM4 Genetic Variants within microRNA Binding Sites with Prostate Cancer: Evidence from Serbian Population. Pathology oncology research : POR 8 32556890
1991 Procedure for the purification of the fibronectin proteolytic fragments containing the ED-B oncofetal domain. Analytical biochemistry 8 2035837
2009 Role of VAMP8/endobrevin in constitutive exocytotic pathway in HeLa cells. Cell structure and function 7 19738360

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