Affinage

STX7

Syntaxin-7 · UniProt O15400

Length
261 aa
Mass
29.8 kDa
Annotated
2026-04-28
53 papers in source corpus 22 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

STX7 is a Qa-SNARE protein that functions as a central organizer of membrane fusion events at late endosomes and lysosomes, participating in multiple distinct SNARE complexes to control endolysosomal trafficking, autophagosome–lysosome fusion, and regulated secretion. On endosomal membranes, STX7 assembles with STX8, Vti1b, and VAMP8 to drive late endosome-to-lysosome fusion (PMID:21388490, PMID:32658937), and independently pairs with SNAP29 and autophagosomal YKT6 to mediate autophagosome–lysosome fusion in a pathway parallel to the STX17-dependent route (PMID:29789439, PMID:38340317). STX7 is subject to regulatory phosphorylation by SGK3 at Ser126 and by CSF-1-activated kinases at Habc-domain serines that modulate SNARE complex assembly (PMID:18710945, PMID:31665227), and its interaction with Munc13-4 (UNC13D) is required for endolysosomal maturation, endosomal TLR signaling, and lytic granule release from cytotoxic T lymphocytes (PMID:30892133, PMID:21438968, PMID:41942734). Beyond canonical endolysosomal roles, STX7 defines a rapidly replenishing synaptic vesicle pool in hippocampal neurons that modulates presynaptic GABA release and seizure susceptibility (PMID:34408265, PMID:37031804), and is co-opted by intracellular pathogens including influenza A virus, Salmonella, Chlamydia, and Plasmodium to facilitate infection (PMID:39653855, PMID:40444290, PMID:39154341, PMID:41972675).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2008 High

    The question of how extracellular signals regulate endosomal SNARE complex assembly was addressed by showing that CSF-1 induces serine phosphorylation of STX7's Habc domain, directly enhancing its binding to Vti1b, STX8, and VAMP8 in primary macrophages.

    Evidence Serine mutagenesis, co-IP of SNARE partners, kinase inhibitors in primary mouse macrophages

    PMID:18710945

    Open questions at the time
    • Identity of the specific kinase(s) directly phosphorylating the Habc domain serines not definitively established
    • Functional consequence of phosphorylation on membrane fusion rates not measured directly
  2. 2011 High

    Two studies established STX7 as a core Qa-SNARE of multiple endosomal fusion complexes and revealed its requirement in immune cell effector function: STX7 participates in STX6/STX7/Vti1b and STX7/STX8/Vti1b complexes in macrophages, and is required for lytic granule delivery to the immunological synapse in CTLs.

    Evidence Reciprocal co-IP with siRNA rescue in macrophages; dominant-negative STX7, siRNA, STED nanoscopy, and killing assays in CTLs

    PMID:21388490 PMID:21438968

    Open questions at the time
    • Whether STX7 loss phenocopies the complete SNARE complex disruption or whether compensatory SNAREs exist in CTLs
    • Structural basis of STX7 selectivity for different R-SNARE partners not resolved
  3. 2014 Medium

    STX7 was placed in a specific fusogenic complex (STX7/STX8/Vti1b/VAMP8) recruited by UVRAG to mediate viral endocytic entry, linking the canonical endosomal SNARE machinery to virus-host interactions.

    Evidence Co-IP, siRNA depletion, influenza A and VSV infection assays

    PMID:24550300

    Open questions at the time
    • STX7's individual contribution versus collective complex requirement not separated
    • Whether UVRAG directly activates STX7 or acts upstream through tethering
  4. 2015 Medium

    The recycling of STX7-containing SNARE complexes was shown to require γ-SNAP-mediated disassembly, establishing the first regulatory step for SNARE complex turnover at endosomes.

    Evidence IP-MS, siRNA depletion, endosome morphology and EGFR/transferrin trafficking assays

    PMID:26101353

    Open questions at the time
    • Whether γ-SNAP acts directly on assembled STX7 complexes or on individual SNAREs post-disassembly
    • Quantitative kinetics of SNARE disassembly not determined
  5. 2017 High

    A reconstituted in vitro fusion assay demonstrated that STX7 mediates homotypic phagophore-phagophore fusion, revealing a role upstream of autophagosome-lysosome fusion in autophagosome biogenesis itself.

    Evidence In vitro membrane fusion assay, electron microscopy, siRNA in HCV-infected cells

    PMID:28931085

    Open questions at the time
    • SNARE partners for the phagophore fusion event not fully defined
    • Whether this mechanism operates outside HCV-induced autophagy
  6. 2018 High

    The discovery that STX7 forms a SNAP29/YKT6 complex on lysosomes to mediate autophagosome-lysosome fusion independently of STX17 resolved how autophagy can proceed when the canonical STX17 pathway is absent.

    Evidence STX17-KO HeLa cells, reciprocal co-IP, fluorescence microscopy of autophagosome-lysosome fusion

    PMID:29789439

    Open questions at the time
    • Relative contribution of STX7 versus STX17 pathway under physiological conditions unknown
    • How selectivity between the two parallel pathways is achieved
  7. 2019 High

    Two independent findings defined kinase-level and effector-level regulation of STX7: SGK3 phosphorylates STX7 at Ser126 specifically at endosomes, and the Munc13-4 (UNC13D) interaction with STX7 is required for endolysosomal maturation.

    Evidence In vitro kinase assay with SGK3/Akt, SGK3-KO cells, Phos-tag gels; UNC13D-null cell rescue with STX7-binding-deficient mutant

    PMID:30892133 PMID:31665227

    Open questions at the time
    • Functional consequence of Ser126 phosphorylation on STX7 SNARE complex assembly or fusion not shown
    • Whether SGK3 and Munc13-4 act on the same or different STX7 complexes
  8. 2020 Medium

    A systematic RNAi screen confirmed STX7, STX8, VTI1B, and VAMP7/8 as a complete late endosomal SNARE machinery acting in conjunction with the RAB7/HOPS tethering system, using Salmonella-induced filament formation as a readout for endolysosomal membrane dynamics.

    Evidence Sub-genomic RNAi screen with high-resolution live-cell imaging in Salmonella-infected cells

    PMID:32658937

    Open questions at the time
    • Whether STX7 is rate-limiting within this complex or exchangeable
    • HOPS-STX7 direct interaction not demonstrated
  9. 2021 Medium

    Two studies extended STX7 function to neuronal and macrophage trafficking: STX7 defines a rapidly replenishing presynaptic vesicle pool dependent on actin and Ca²⁺/calmodulin, and the VAMP4/STX6/STX7/Vti1b complex mediates Golgi-to-late endosome trafficking of MT1-MMP for macrophage invasion.

    Evidence Dominant-negative STX7 N-terminal domain in hippocampal neurons with pharmacology; siRNA and overexpression with gelatin degradation in macrophages

    PMID:34408265 PMID:34476885

    Open questions at the time
    • Whether STX7 marks a molecularly distinct vesicle subpopulation or labels general endosomal vesicles entering the presynaptic pool
    • Direct Ca²⁺/calmodulin binding to STX7 not tested
  10. 2022 Medium

    STX7 was shown to form non-canonical SNARE complexes with VAMP2, VAMP3, VAMP7, STX4, and SNAP23 to drive invadopodia formation and MT1-MMP delivery in breast cancer cells, expanding its partner repertoire beyond canonical endolysosomal SNAREs.

    Evidence siRNA screen of 13 SNAREs, TIRF microscopy, co-IP, invasion assays in MDA-MB-231 cells

    PMID:35762511

    Open questions at the time
    • Whether these non-canonical complexes are unique to cancer cell invasion or occur broadly
    • Structural basis for STX7 promiscuity in partner selection unknown
  11. 2023 Medium

    STX7 was linked to seizure susceptibility through regulation of presynaptic GABA release and inhibitory vesicle density, establishing a neurophysiological function beyond vesicle pool definition.

    Evidence STX7 overexpression and knockdown in kainic acid and PTZ kindling mouse models, patch-clamp electrophysiology, transmission EM

    PMID:37031804

    Open questions at the time
    • Which SNARE partners mediate the inhibitory vesicle phenotype in neurons
    • Whether STX7 loss in specific neuronal subtypes is sufficient for the seizure phenotype
  12. 2024 High

    Multiple discoveries in 2024 refined the mechanistic hierarchy of autophagosomal SNARE complexes and revealed pathogen exploitation of STX7: YKT6 primes a complex with STX17/SNAP29 that is displaced by VAMP8 for fusion, while the parallel STX7/SNAP29/YKT6 complex independently promotes fusion; IFITM3 inhibits STX7-containing SNARE complex assembly via a SNARE-like motif to restrict viral entry; and Chlamydia effector IncE recruits STX7-containing vesicles via a SNARE-mimetic SLiM.

    Evidence In vitro lipid/content mixing assays with co-IP for complex hierarchy; in vitro binding, mutagenesis, and IAV infection for IFITM3; SLiM mutagenesis with bacterial development assays for Chlamydia

    PMID:38340317 PMID:39154341 PMID:39653855

    Open questions at the time
    • How IFITM3's inhibition of STX7 is regulated during infection
    • Whether Chlamydia IncE competes with cellular STX7 partners or captures a distinct pool
  13. 2025 High

    Chemical biology and pathogen studies converged to establish the Munc13-4–STX7 interaction as a druggable node controlling endosomal TLR signaling, and revealed that Salmonella and Plasmodium both exploit host STX7-containing SNARE machinery for intracellular survival.

    Evidence HTS-derived ENDOtollin inhibitors of Munc13-4–STX7, endolysosomal flux and TLR assays, in vivo CpG model; BioID, siRNA/rescue, bacterial survival for Salmonella; combinatorial CRISPR KO and imaging for Plasmodium

    PMID:40444290 PMID:41942734 PMID:41972675

    Open questions at the time
    • Structural basis of Munc13-4–STX7 interaction not resolved at atomic level
    • Whether ENDOtollins affect all STX7-dependent fusion events or are pathway-selective
    • Relative contribution of STX7 versus other SNAREs at the parasitophorous vacuole

Open questions

Synthesis pass · forward-looking unresolved questions
  • No high-resolution structure of STX7 alone or in a SNARE complex exists, the mechanism by which STX7 selects among its diverse R-SNARE partners in different cellular contexts is unresolved, and the functional consequences of Ser126 phosphorylation by SGK3 on SNARE complex dynamics remain untested.
  • No crystal or cryo-EM structure of STX7 or STX7-containing SNARE complex
  • Partner selectivity mechanism unknown
  • SGK3 phosphorylation functional output undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 4
Localization
GO:0005768 endosome 5 GO:0005764 lysosome 3 GO:0005886 plasma membrane 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 5 R-HSA-9612973 Autophagy 3 R-HSA-112316 Neuronal System 2 R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 2
Partners
IFITM3SNAP29STX6STX8UNC13DVAMP8VTI1BYKT6
Complex memberships
STX6/STX7/Vti1b/VAMP4STX7/SNAP29/YKT6STX7/STX8/Vti1b/VAMP8

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2018 STX7 (lysosomal) forms a SNARE complex with SNAP29 and autophagosomal YKT6 to mediate autophagosome-lysosome fusion independently of STX17; YKT6 depletion completely blocked fusion in STX17-knockout cells, establishing two independent SNARE complexes for autophagosomal fusion. STX17 knockout HeLa cells, siRNA depletion of YKT6, co-immunoprecipitation of SNARE complex, fluorescence microscopy of autophagosome-lysosome fusion The Journal of cell biology High 29789439
2011 STX7 is required for lytic granule release from cytotoxic T lymphocytes (CTLs); it localizes to the immunological synapse and late endosomes (co-localizing with Rab7), and its loss prevents both TCR recycling through endosomes and lytic granule accumulation at the IS, without reducing total granule number. Dominant-negative STX7 expression, siRNA knockdown, evanescent wave microscopy of individual lytic granules, high-resolution STED nanoscopy, CTL killing assay Traffic (Copenhagen, Denmark) High 21438968
2011 STX7 participates in SNARE complexes STX6/STX7/Vti1b and STX7/STX8/Vti1b on endosomal membranes; STX11 regulates late endosome-to-lysosome fusion by controlling availability of Vti1b to form these Q-SNARE complexes, establishing STX7 as a component of the endosomal fusion machinery in macrophages. Co-immunoprecipitation of SNARE complexes, siRNA depletion, rescue with siRNA-resistant construct, live imaging of endocytic compartments in macrophages Traffic (Copenhagen, Denmark) High 21388490
2008 CSF-1 upregulates STX7 expression in primary macrophages and induces rapid serine phosphorylation of STX7, enhancing its binding to SNARE partners Vti1b, STX8, and VAMP8; mutagenesis of serine residues in the Habc domain and/or linker region identified these as the sites through which CSF-1 regulates SNARE complex assembly. Primary mouse macrophage culture, kinase inhibitor studies, mutagenesis of STX7 serine residues, co-immunoprecipitation of SNARE partners, western blotting Molecular and cellular biology High 18710945
2014 UVRAG mediates viral endocytic transport through interaction with endosomal Q-SNAREs including STX7, STX8, and Vti1b, leading to assembly of a fusogenic trans-SNARE complex with VAMP8; inhibition of VAMP8 (but not VAMP7) significantly reduces viral entry, placing STX7 in the specific SNARE complex required for influenza A and VSV entry. Co-immunoprecipitation, siRNA depletion, viral infection assays, VAMP isoform-selective inhibition Proceedings of the National Academy of Sciences of the United States of America Medium 24550300
2015 γ-SNAP mediates disassembly of endosomal STX7-containing SNARE complexes; immunoprecipitation combined with mass spectrometry showed γ-SNAP preferentially interacts with endosomal SNAREs, and its depletion altered endosome morphology and delayed EGFR and transferrin trafficking from early endosomes. Immunoprecipitation, mass spectrometry, siRNA depletion, overexpression, endosome morphology analysis Journal of cell science Medium 26101353
2017 STX7 is required for homotypic fusion of phagophores to generate HCV-induced autophagosomes; in vitro membrane fusion assay demonstrated STX7-dependent phagophore-phagophore fusion, and STX7 knockdown blocked autophagosome formation without affecting HCV RNA replication on phagophore membranes. In vitro membrane fusion assay, electron microscopy, siRNA knockdown, live-cell imaging PLoS pathogens High 28931085
2019 SGK3 phosphorylates STX7 at Ser126 at endosomes; phosphoproteomic screening and in vitro kinase assays confirmed STX7 Ser126 as an SGK3-specific substrate (poorly phosphorylated by Akt), and IGF1 stimulation in HEK293 cells promoted endogenous STX7 phosphorylation in an SGK3-dependent manner. Phosphoproteomic screen, in vitro kinase assay with purified SGK3 and Akt, Phos-tag gel analysis, SGK3 knockout cells, pan-SGK inhibitor treatment The Biochemical journal High 31665227
2019 UNC13D binds STX7 on late endosomes and regulates endosomal maturation; a STX7-binding-deficient UNC13D mutant failed to rescue defective endosomal trafficking in unc13d-null cells, establishing that the UNC13D-STX7 interaction is required for endolysosomal flux. unc13d-null cells, rescue with STX7-binding-deficient UNC13D mutant, endocytic flux assays, biochemical and microscopy methods Autophagy Medium 30892133
2020 STX7, STX8, VTI1B, and VAMP7/8 form a complete late endo-/lysosomal SNARE fusion machinery required for Salmonella-induced filament (SIF) formation; RNAi screen showed each component is individually required for SIF morphology in conjunction with RAB7 and HOPS tethering complex. Sub-genomic RNAi screen, high-resolution live-cell imaging, SIF morphology scoring PLoS pathogens Medium 32658937
2021 STX7 (endosomal Q-SNARE) defines a rapidly replenishing synaptic vesicle pool in hippocampal neurons; disruption of STX7 function by overexpressing its N-terminal domain selectively abolished this pool, and recruitment of STX7-marked vesicles requires actin polymerization and Ca2+/calmodulin signaling. Optical imaging of presynaptic endosomal SNARE proteins, dominant-negative N-terminal domain overexpression, pharmacological inhibition of actin polymerization and Ca2+/calmodulin signaling in cultured hippocampal neurons Communications biology Medium 34408265
2021 The trans-SNARE complex VAMP4/STX6/STX7/Vti1b mediates Golgi-to-late-endosome trafficking of MT1-MMP in macrophages; depletion of any SNARE in this complex reduced surface MT1-MMP and gelatin degradation, while overexpression of STX6/STX7/Vti1b increased surface MT1-MMP. Fixed and live imaging, siRNA depletion, overexpression, gelatin degradation assay in LPS-activated macrophages Traffic (Copenhagen, Denmark) Medium 34476885
2022 STX7 promotes invadopodia formation and breast cancer cell invasion by forming distinct SNARE complexes with VAMP2, VAMP3, VAMP7, STX4, and SNAP23; STX7 depletion reduced invadopodia number and associated MT1-MMP at invadopodia, while increasing non-invadosomal MT1-MMP pools. siRNA screening of 13 SNAREs, TIRF microscopy, co-trafficking with MT1-MMP, immunoprecipitation, invasion assays in MDA-MB-231 cells Journal of cell science Medium 35762511
2023 STX7 modulates seizure susceptibility by regulating presynaptic GABA release; overexpression of STX7 reduced seizure susceptibility in kainic acid and PTZ kindling models, affecting excitation/inhibition ratio and inhibitory vesicle density without changing intrinsic neuronal excitability or inhibitory synapse density. Kainic acid and PTZ kindling mouse models, STX7 overexpression and knockdown, whole-cell patch-clamp recordings, transmission electron microscopy Neurobiology of disease Medium 37031804
2024 YKT6 forms a priming complex with STX17 and SNAP29 on autophagosomes via its SNARE domain; VAMP8 displaces YKT6 from this complex to form the fusogenic STX17-SNAP29-VAMP8 complex, with the YKT6-SNAP29-STX17 complex facilitating both lipid and content mixing to promote autophagy flux. STX7 (lysosomal) participates in the parallel STX7-SNAP29-YKT6 fusogenic complex. Co-immunoprecipitation, lipid mixing assay, content mixing assay, autophagy flux measurement Cell reports High 38340317
2024 IFITM3 binds STX7 in cells and in vitro via a SNARE-like motif in its CD225 domain; mutations that abrogate STX7 binding cause loss of antiviral activity against influenza A virus, and mechanistically IFITM3 disrupts assembly of the STX7-containing SNARE complex controlling homotypic late endosome fusion, accelerating cargo trafficking to lysosomes. Co-immunoprecipitation in cells, in vitro binding assay, mutagenesis of SNARE-like motif, influenza A virus infection assay, endosomal cargo trafficking assay The EMBO journal High 39653855
2024 Chlamydia effector IncE binds STX7- and STX12-containing vesicles via a proximal SNARE-mimetic short linear motif (SLiM) in its C-terminus, recruiting these vesicles to the Chlamydia inclusion to facilitate intracellular bacterial development. SLiM mutagenesis, vesicle recruitment assays, co-localization microscopy, functional bacterial development assays Cell reports Medium 39154341
2025 Munc13-4 specifically interacts with STX7 to regulate endolysosomal flux and endosomal TLR signaling; small-molecule ENDOtollins inhibiting the Munc13-4-STX7 interaction blocked endolysosomal cargo degradation and reduced TLR3/7/9-driven inflammatory cytokine production in dendritic cells and neutrophils without affecting plasma membrane TLR responses. High-throughput small-molecule screening, orthogonal cell-based validation, endolysosomal flux assay, TLR ligand stimulation assays, in vivo CpG-induced inflammation model Nature chemical biology High 41942734
2025 Salmonella Typhimurium hijacks STX7 to evade lysosomal fusion and maintain its intracellular vacuolar niche; STX7 knockdown reduced bacterial survival rescued by STX7 overexpression, STX7 is recruited to SCVs with altered distribution at late infection stages, and SPI-2 effectors SifA and SopD2 interact with STX7 by BioID proximity labeling. BioID proximity labeling, siRNA knockdown, overexpression rescue, live cell imaging, bacterial survival assay in HeLa and RAW264.7 cells Traffic (Copenhagen, Denmark) Medium 40444290
2025 STX7 is identified as a direct binding target of capsazepine in astrocytes; drug affinity responsive target stability (DARTS) analysis, cellular thermal shift assay, and molecular docking demonstrated capsazepine binding to STX7, and STX7 siRNA knockdown phenocopied capsazepine's anti-inflammatory effects on astrocyte activation. DARTS analysis, cellular thermal shift assay (CETSA), molecular docking, siRNA knockdown, in vitro and in vivo astrocyte inflammation models FASEB journal Medium 40386937
2025 STX7, VAMP8, VTI1B, and VAMP7 are recruited to the Plasmodium parasitophorous vacuole membrane (PVM) with distinct temporal profiles; combinatorial CRISPR knockouts showed VAMP7-VAMP8 and VAMP7-VTI1B double KOs significantly reduced parasite infection and growth, with STX7 appearing at PVM ~24 hpi during nutrient acquisition, indicating host SNARE machinery is co-opted for lysosome-PVM fusion. CRISPR/Cas9 knockout in HeLa cells, advanced fluorescence microscopy of P. berghei-infected cells, combinatorial knockout analysis Cells Medium 41972675
2025 siRNA screening identified STX7, STX8, and VTI1B as components of the lysosomal SNARE machinery required for secretory granule-lysosome fusion (crinophagy); Munc13-4 associates with these SNAREs and regulates docking and fusion of secretory granules with lysosomes in a calcium-dependent manner. siRNA screening with live-cell SG-lysosome fusion assay, co-immunoprecipitation of Munc13-4 with SNARE partners, calcium manipulation experiments Research square (preprint)preprint Medium 40951263

Source papers

Stage 0 corpus · 53 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. The American journal of psychiatry 261 18198266
2018 Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. The Journal of cell biology 189 29789439
2021 TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy. Autophagy 79 33779513
2004 Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. American journal of human genetics 75 15329799
2017 Mfsd2a (Major Facilitator Superfamily Domain Containing 2a) Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Inhibiting Vesicular Transcytosis. Journal of the American Heart Association 69 28724654
2011 Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. Traffic (Copenhagen, Denmark) 54 21388490
2011 Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes. Traffic (Copenhagen, Denmark) 40 21438968
2014 UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proceedings of the National Academy of Sciences of the United States of America 34 24550300
2011 The cystic fibrosis transmembrane conductance regulator's expanding SNARE interactome. Traffic (Copenhagen, Denmark) 29 21223469
2017 HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication. PLoS pathogens 25 28931085
2007 Identification of novel genes associated with dominant follicle development in cattle. Reproduction, fertility, and development 25 18076829
2024 Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion. Cell reports 24 38340317
2025 Identification of immune-inflammation targets for intracranial aneurysms: a multiomics and epigenome-wide study integrating summary-data-based Mendelian randomization, single-cell-type expression analysis, and DNA methylation regulation. International journal of surgery (London, England) 21 39051921
2008 Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages. Molecular and cellular biology 21 18710945
2017 Identification of TWIST-interacting genes in prostate cancer. Science China. Life sciences 20 28120266
2009 Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma. Journal of proteome research 20 19714869
2021 A Genome-wide Association Study Identifies SERPINB10, CRLF3, STX7, LAMP3, IFNG-AS1, and KRT80 As Risk Loci Contributing to Cutaneous Leishmaniasis in Brazil. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 19 32830257
2021 Proteomic identification of select protein variants of the SNARE interactome associated with cognitive reserve in a large community sample. Acta neuropathologica 18 33646358
2021 The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons. Communications biology 18 34408265
2020 A trafficome-wide RNAi screen reveals deployment of early and late secretory host proteins and the entire late endo-/lysosomal vesicle fusion machinery by intracellular Salmonella. PLoS pathogens 18 32658937
2015 γ-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways. Journal of cell science 17 26101353
2020 Enhanced Cd accumulation by Graphene oxide (GO) under Cd stress in duckweed. Aquatic toxicology (Amsterdam, Netherlands) 16 33075615
2020 Heat Stress Impairs the Physiological Responses and Regulates Genes Coding for Extracellular Exosomal Proteins in Rat. Genes 15 32183190
2019 Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency. Autophagy 15 30892133
2019 Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44. The Biochemical journal 15 31665227
2021 The trans-SNARE complex VAMP4/Stx6/Stx7/Vti1b is a key regulator of Golgi to late endosome MT1-MMP transport in macrophages. Traffic (Copenhagen, Denmark) 12 34476885
2020 PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation. Autophagy 12 33112705
2022 Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation. Journal of cell science 11 35762511
2017 Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence. Translational oncology 10 28433799
2025 Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma. Nature cell biology 8 41315767
2023 Establishing Molecular Subgroups of CD8+ T Cell-Associated Genes in the Ovarian Cancer Tumour Microenvironment and Predicting the Immunotherapy Response. Biomedicines 8 37760841
2024 The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking. Cell reports 7 39154341
2024 SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion. The EMBO journal 7 39653855
2024 GORASP2 promotes phagophore closure and autophagosome maturation into autolysosomes. Autophagy 6 39056394
2022 Diesel exhaust particles induce human umbilical vein endothelial cells apoptosis by accumulation of autophagosomes and caspase-8 activation. Scientific reports 6 36192481
2023 Syntaxin 7 modulates seizure activity in epilepsy. Neurobiology of disease 5 37031804
2021 Long Noncoding RNA NTT Context-Dependently Regulates MYB by Interacting With Activated Complex in Hepatocellular Carcinoma Cells. Frontiers in oncology 4 34616668
2024 Identification of the role of SNARE proteins in rAAV vector production through interaction with the viral MAAP. Molecular therapy. Methods & clinical development 3 39807420
2022 In silico analysis of microRNA genes in azoospermia factor Y-chromosome microdeletions. International urology and nephrology 3 35124761
2024 Exploring temporal and sex-linked dysregulation in Alzheimer disease phosphoproteome. iScience 2 39391719
2023 Comparative Hippocampal Proteome and Phosphoproteome in a Niemann-Pick, Type C1 Mouse Model Reveal Insights into Disease Mechanisms. Journal of proteome research 2 37999680
2016 An Immunohistochemical Survey of SNARE Proteins Shows Distinct Patterns of Expression in Hematolymphoid Neoplasia. American journal of clinical pathology 2 27247366
2025 Capsazepine Inhibits Astrocyte Activation and Attenuates Neuroinflammation by Targeting Syntaxin 7. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 40386937
2025 Salmonella Typhimurium Manipulates Syntaxin 7 to Navigate Endo-Lysosomal Trafficking in Host Cells. Traffic (Copenhagen, Denmark) 1 40444290
2025 Proteomic insights into early pancreatic ductal adenocarcinoma biology and screening. Discover oncology 1 40789825
2024 SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion. bioRxiv : the preprint server for biology 1 41030966
2026 Munc13-4-STX7 inhibitors impair endosomal TLR activation and systemic inflammation. Nature chemical biology 0 41942734
2026 Host SNARE Proteins Mediate Lysosome and PVM Fusion to Support Plasmodium Liver Infection. Cells 0 41972675
2025 Molecular requirements for mammalian crinophagy highlight a key role for Ca2+-dependent Munc13-4. Research square 0 40951263
2025 Syntaxin-7 promotes EMT and tumor progression via NF-κB signaling and is associated with macrophage infiltration: pan-cancer analysis and experimental validation in hepatocellular carcinoma. BMC cancer 0 40999361
2024 MicroRNAs correlate with bacillary index and genes associated to cell death processes in leprosy. Microbes and infection 0 38224943
2023 Exploring Temporal and Sex-Linked Dysregulation in Alzheimer's Disease Phospho-Proteome. bioRxiv : the preprint server for biology 0 37645993
2023 Conserved regulation of autophagosome-lysosome fusion through YKT6 phosphorylation. Autophagy reports 0 40395297