Affinage

STX7

Syntaxin-7 · UniProt O15400

Length
261 aa
Mass
29.8 kDa
Annotated
2026-06-10
53 papers in source corpus 24 papers cited in narrative 24 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

STX7 is a late endosomal/lysosomal Qa-SNARE that nucleates multiple endosomal SNARE complexes to drive membrane fusion across the endolysosomal and autophagic pathways (PMID:21388490, PMID:34476885). It assembles with Vti1b and STX8 (with VAMP7 or VAMP8) to mediate late endosome-to-lysosome fusion, and with STX6/Vti1b/VAMP4 to direct Golgi-to-late-endosome trafficking of cargo such as MT1-MMP (PMID:21388490, PMID:34476885); in the autophagy pathway it participates in a YKT6-SNAP29-STX7 complex on lysosomes that supports content and lipid mixing during autophagosome-lysosome fusion, providing a route parallel to the STX17-SNAP29-VAMP8 machinery (PMID:29789439, PMID:38340317), and it is also required for homotypic phagophore fusion (PMID:28931085). STX7-dependent fusion supports diverse physiological outputs, including lytic granule release and recycling TCR trafficking in cytotoxic T lymphocytes (PMID:21438968), a rapidly mobilized synaptic vesicle recycling pool and presynaptic inhibitory neurotransmission (PMID:34408265, PMID:37031804), and MT1-MMP delivery driving invadopodia formation (PMID:35762511, PMID:34476885). Its activity is regulated by phosphorylation: CSF-1 signaling through PI3K/PKC/Akt induces serine phosphorylation in the Habc/linker region that enhances binding to Vti1b, STX8, and VAMP8 (PMID:18710945), and SGK3 directly phosphorylates STX7 at Ser126 downstream of IGF1 (PMID:31665227), while disassembly of STX7 complexes is mediated by γ-SNAP (PMID:26101353). STX7 is a recurrent target of host and pathogen factors that manipulate endolysosomal flux: it is bound by Munc13-4/UNC13D to control endosomal maturation and endosomal TLR signaling (PMID:30892133, PMID:41942734), engaged by the antiviral effector IFITM3 via a SNARE-like CD225 motif that disrupts STX7 complex assembly (PMID:39653855), and hijacked by intracellular pathogens including Chlamydia (IncE), Salmonella, and Plasmodium to evade or remodel the endolysosomal system (PMID:39154341, PMID:40444290).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2008 High

    Established that STX7 SNARE-complex assembly is signal-regulated, showing how an upstream growth-factor cascade tunes endolysosomal fusion capacity.

    Evidence Kinase inhibitor pharmacology, site-directed mutagenesis, and co-IP in CSF-1-stimulated primary macrophages

    PMID:18710945

    Open questions at the time
    • Precise phosphorylated residues not definitively mapped
    • Structural basis for enhanced partner binding unresolved
  2. 2011 Medium

    Defined the regulatory logic of STX7 complex formation and a physiological output, showing STX11 controls Vti1b availability for STX6/STX7/Vti1b and STX7/STX8/Vti1b complexes, and that STX7 is required for CTL lytic granule release.

    Evidence Co-IP, siRNA depletion, and functional trafficking/CTL killing assays in macrophages and cytotoxic T lymphocytes

    PMID:21388490 PMID:21438968

    Open questions at the time
    • Stoichiometry of competing complexes not quantified
    • Direct fusogenic activity not reconstituted in these studies
  3. 2014 Medium

    Showed STX7 endosomal Q-SNARE complexes are co-opted for viral entry, linking UVRAG-organized STX7/STX8/Vti1b/VAMP8 assembly to influenza A and VSV membrane penetration.

    Evidence Reciprocal co-IP and viral entry assays with VAMP8 vs VAMP7 inhibition

    PMID:24550300

    Open questions at the time
    • Direct role of STX7 versus other complex members in fusion not isolated
    • Single lab
  4. 2015 Medium

    Identified the disassembly arm of the STX7 cycle, showing γ-SNAP disassembles STX7 complexes and is needed for EGFR/transferrin exit from early endosomes.

    Evidence Co-IP/MS, siRNA, SNARE disassembly assay, and cargo trafficking imaging

    PMID:26101353

    Open questions at the time
    • Whether γ-SNAP acts directly on STX7 vs partner subunits unclear
    • Cargo specificity mechanism not defined
  5. 2017 Medium

    Extended STX7 function into autophagosome biogenesis, demonstrating it drives homotypic phagophore fusion distinct from later fusion steps.

    Evidence siRNA knockdown plus in vitro membrane fusion assay and EM in HCV-induced phagophore system

    PMID:28931085

    Open questions at the time
    • SNARE partners for homotypic phagophore fusion not specified
    • Generalizability beyond HCV context not tested
  6. 2018 High

    Revealed a STX17-independent autophagosome-lysosome fusion route, placing STX7 in a YKT6-SNAP29-STX7 complex.

    Evidence SNARE screen and co-IP in STX17 knockout HeLa cells with fluorescence microscopy

    PMID:29789439

    Open questions at the time
    • Relative contribution of STX7 vs STX17 pathways in vivo unquantified
    • Membrane topology of the complex not resolved here
  7. 2019 High

    Identified a second kinase input and a functional partner, mapping SGK3 phosphorylation at STX7 Ser126 and demonstrating UNC13D-STX7 binding is required for endosomal maturation.

    Evidence In vitro kinase assay, SGK3 KO, and Phos-tag gels (Ser126); structure-function rescue with STX7-binding-deficient UNC13D mutant

    PMID:30892133 PMID:31665227

    Open questions at the time
    • Functional consequence of Ser126 phosphorylation on fusion not established
    • Structural interface of UNC13D-STX7 not solved
  8. 2021 Medium

    Broadened STX7's physiological roles, defining a rapidly replenishing STX7-marked synaptic vesicle pool and a VAMP4/STX6/STX7/Vti1b complex controlling MT1-MMP trafficking.

    Evidence Presynaptic SNARE optical imaging with dominant-negative/pharmacology; siRNA, overexpression, and gelatin degradation assays in macrophages

    PMID:34408265 PMID:34476885

    Open questions at the time
    • Mechanism coupling STX7 to actin/Ca2+/CaM-dependent SV pool recruitment unknown
    • How distinct STX7 complexes are spatially segregated unclear
  9. 2022 Medium

    Linked STX7 to cancer cell invasion, showing STX7 co-traffics with MT1-MMP and forms VAMP2/VAMP3/VAMP7/STX4/SNAP23 complexes required for invadopodia.

    Evidence siRNA, TIRF imaging, co-IP, and gelatin degradation in MDA-MB-231 cells

    PMID:35762511

    Open questions at the time
    • Which plasma-membrane vs endosomal complex drives degradative activity not separated
    • Single cell line
  10. 2024 High

    Resolved sequential SNARE assembly in autophagy and defined an antiviral host mechanism, showing VAMP8 displaces YKT6 to form the fusogenic STX17 complex while STX7 mediates lysosomal mixing, and that IFITM3 binds STX7 to block its complex assembly.

    Evidence Lipid/content mixing assays and dominant-negatives; co-IP, in vitro binding, mutagenesis, and influenza A antiviral assays

    PMID:38340317 PMID:39653855

    Open questions at the time
    • In vivo relevance of YKT6-STX7 mixing step not established
    • Structural model of IFITM3-STX7 interaction lacking
  11. 2025 Medium

    Documented pathogen subversion and disease-relevant phenotypes, showing Chlamydia IncE and Salmonella effectors engage STX7, and that STX7 modulates seizure susceptibility, hepatocellular carcinoma growth, and astrocyte inflammation.

    Evidence SLiM mutagenesis/recruitment assays (Chlamydia); knockdown/rescue, live imaging, and BioID (Salmonella); rodent epilepsy electrophysiology; CRISPR KO xenograft; DARTS/CETSA drug-target validation

    PMID:37031804 PMID:39154341 PMID:40386937 PMID:40444290 PMID:40999361

    Open questions at the time
    • Direct molecular contribution of STX7 to NF-κB and inflammation not mechanistically resolved
    • Pathogen-effector binding interfaces not structurally defined
  12. 2026 Medium

    Demonstrated therapeutic targetability of the Munc13-4-STX7 interaction, showing small-molecule disruptors selectively inhibit endosomal TLR signaling and reduce systemic inflammation in vivo.

    Evidence High-throughput screening, cell-based interaction inhibition, TLR signaling assays, and in vivo CpG challenge

    PMID:41942734

    Open questions at the time
    • Selectivity of inhibitors across STX7 complexes not fully mapped
    • Off-target endolysosomal consequences not characterized

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the cell selects among the many mutually exclusive STX7-containing SNARE complexes at specific membranes and how the two characterized phosphorylation inputs alter fusion kinetics remains unresolved.
  • No structural model of any full STX7 fusogenic complex
  • Functional link between Ser126/Habc phosphorylation and fusion rate undefined
  • Spatial regulation of partner choice unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 4 GO:0060090 molecular adaptor activity 3
Localization
GO:0005764 lysosome 4 GO:0005768 endosome 4
Pathway
R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-9612973 Autophagy 3 R-HSA-168256 Immune System 2
Partners
IFITM3SNAP29STX6STX8UNC13DVAMP8VTI1BYKT6
Complex memberships
STX6/STX7/Vti1b/VAMP4STX7/STX8/Vti1b/VAMP8YKT6/SNAP29/STX7

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2018 YKT6 forms a SNARE complex with SNAP29 and lysosomal STX7 on autophagosomes, providing a second pathway for autophagosome-lysosome fusion that is independent of STX17; depletion of YKT6 completely blocked autophagosome-lysosome fusion in STX17 KO cells. STX17 knockout HeLa cells, SNARE screen, co-immunoprecipitation, fluorescence microscopy The Journal of cell biology High 29789439
2024 YKT6 forms a priming complex with STX17 and SNAP29 on autophagosomes via its SNARE domain; VAMP8 then displaces YKT6 to form the fusogenic STX17-SNAP29-VAMP8 complex, with STX7 participating in the YKT6-SNAP29-STX7 complex at lysosomes to mediate content and lipid mixing. Co-immunoprecipitation, lipid and content mixing assays, dominant-negative constructs, autophagy flux assays Cell reports High 38340317
2011 STX7 is required for lytic granule release from cytotoxic T lymphocytes (CTLs); it localizes preferentially to the immunological synapse and mediates trafficking of recycling TCRs through late endosomes (colocalizing with Rab7), which is a prerequisite for lytic granule accumulation and CTL-mediated killing. Dominant-negative STX7 expression, siRNA knockdown, evanescent wave microscopy, high-resolution nanoscopy, functional CTL killing assay Traffic (Copenhagen, Denmark) High 21438968
2008 CSF-1 induces serine phosphorylation of STX7 via PKC and Akt downstream of PI3K activation; this phosphorylation, mapped to the Habc domain and/or linker region by mutagenesis, enhances STX7 binding to its SNARE partners Vti1b, STX8, and VAMP8 and upregulates STX7 expression in macrophages. Primary mouse macrophage culture, kinase inhibitor pharmacology, site-directed mutagenesis, co-immunoprecipitation, Western blot Molecular and cellular biology High 18710945
2014 UVRAG mediates viral endocytic transport and membrane penetration through interactions with endosomal Q-SNAREs STX7, STX8, and Vti1b, leading to assembly of a fusogenic trans-SNARE complex involving VAMP8 (but not VAMP7); inhibition of VAMP8 significantly reduces influenza A and VSV entry. Co-immunoprecipitation, viral entry assays, siRNA knockdown, VAMP8/VAMP7 inhibition Proceedings of the National Academy of Sciences of the United States of America Medium 24550300
2011 STX11 binds Vti1b and regulates the availability of Vti1b to form Q-SNARE complexes including STX6/STX7/Vti1b and STX7/STX8/Vti1b that mediate late endosome to lysosome fusion in macrophages; mutant STX11 sequesters Vti1b from these complexes. Co-immunoprecipitation, siRNA depletion, confocal microscopy, functional endosomal trafficking assays in macrophages Traffic (Copenhagen, Denmark) Medium 21388490
2019 SGK3 directly phosphorylates STX7 at Ser126 in a site that is inefficiently phosphorylated by Akt; IGF1-stimulated STX7 phosphorylation in HEK293 cells is blocked by SGK3 knockout or pan-SGK inhibitor, identifying STX7 as a specific endosomal substrate of SGK3. Phosphoproteomics screen, in vitro kinase assay, SGK3 knockout cells, Phos-tag gel electrophoresis, IGF1 stimulation The Biochemical journal High 31665227
2015 γ-SNAP mediates disassembly of endosomal STX7-containing SNARE complexes (alongside α-SNAP) and regulates endocytic trafficking of EGFR and transferrin; depletion of γ-SNAP delayed exit of EGFR and transferrin from EEA1-positive early endosomes. Immunoprecipitation, mass spectrometry, siRNA knockdown, SNARE disassembly assay, fluorescence microscopy of EGFR/transferrin trafficking Journal of cell science Medium 26101353
2017 STX7 is required for homotypic fusion of HCV-induced phagophores to generate autophagosomes; knockdown of STX7 inhibits autophagosome formation but does not affect HCV RNA replication, which occurs on phagophore precursors. siRNA knockdown, in vitro membrane fusion assay, electron microscopy, live-cell imaging, fluorescence microscopy PLoS pathogens Medium 28931085
2021 STX7 defines a rapidly replenishing synaptic vesicle (SV) recycling pool in hippocampal neurons; this Stx7-marked pool is preferentially mobilized during high-frequency stimulation and its recruitment requires actin polymerization and Ca2+/calmodulin signaling; overexpression of the STX7 N-terminal domain as a dominant negative selectively abolished this pool. Optical imaging of presynaptic SNARE proteins in cultured hippocampal neurons, dominant-negative overexpression, pharmacological inhibition (actin, Ca2+/CaM pathway), electrophysiology Communications biology Medium 34408265
2022 STX7 localizes near invadopodia and co-traffics with MT1-MMP; STX7 depletion reduces invadopodium number and associated degradative activity; STX7 forms SNARE complexes with VAMP2, VAMP3, VAMP7, STX4, and SNAP23; depletion of VAMP2, VAMP3, or STX4 phenocopies STX7 loss by abolishing invadopodia formation in MDA-MB-231 cells. siRNA knockdown, TIRF microscopy, immunoprecipitation, gelatin degradation assays Journal of cell science Medium 35762511
2021 The trans-SNARE complex VAMP4/STX6/STX7/Vti1b regulates Golgi-to-late-endosome trafficking of MT1-MMP in LPS-activated macrophages; depletion of any complex member reduces surface MT1-MMP and gelatin degradation, while overexpression of STX6/STX7/Vti1b increases surface MT1-MMP. siRNA knockdown, overexpression, fixed and live imaging, surface protein assays, gelatin degradation assay Traffic (Copenhagen, Denmark) Medium 34476885
2019 UNC13D regulates late endosomal trafficking via binding to STX7; a STX7-binding-deficient mutant of UNC13D fails to rescue the defective endosomal trafficking and endocytic flux phenotype of unc13d-null cells, demonstrating that STX7 interaction is functionally required for UNC13D's role in endosomal maturation. unc13d-null cell rescue experiments with wild-type vs. STX7-binding-deficient UNC13D mutant, biochemical and microscopy assays of endocytic flux Autophagy Medium 30892133
2026 Small-molecule inhibitors (ENDOtollins) of the Munc13-4–STX7 interaction block endolysosomal flux and specifically inhibit endosomal TLR signaling (ERK in neutrophils; IRF in plasmacytoid DCs) without affecting plasma membrane TLR agonists; ENDO12 reduced CpG-induced systemic inflammation in vivo. High-throughput small-molecule screening, cell-based validation of Munc13-4-STX7 interaction inhibition, functional TLR signaling assays, in vivo CpG challenge model Nature chemical biology Medium 41942734
2024 IFITM3 binds STX7 in cells and in vitro via a SNARE-like motif in its CD225 domain; mutations that abrogate STX7 binding cause loss of antiviral activity against influenza A virus; mechanistically, IFITM3 disrupts assembly of the STX7-containing SNARE complex controlling homotypic late endosome fusion and accelerates trafficking of endosomal cargo to lysosomes. Co-immunoprecipitation, in vitro binding assay, mutagenesis, influenza A infection assay, endosomal cargo trafficking assay The EMBO journal High 39653855
2024 Chlamydia effector IncE recruits STX7-containing vesicles to the inclusion via a proximal SNARE-mimicking short linear motif (SLiM) that binds STX7 and STX12. Cell biological characterization of IncE SLiM mutants, vesicle recruitment assays, co-localization microscopy Cell reports Medium 39154341
2025 STX7 knockdown reduces Salmonella survival in HeLa and RAW264.7 macrophages, and this is rescued by STX7 overexpression; live imaging shows STX7 is recruited to Salmonella-containing vacuoles (SCVs) at different infection stages, and BioID revealed STX7 interactions with SPI-2 effectors SifA and SopD2, indicating Salmonella hijacks STX7 to evade lysosomal fusion. STX7 siRNA knockdown and overexpression rescue, live cell imaging, BioID proximity labeling Traffic (Copenhagen, Denmark) Medium 40444290
2025 STX7 is identified as a binding target of the anti-inflammatory compound capsazepine; STX7 siRNA knockdown phenocopied capsazepine's anti-inflammatory effects on astrocytes; interaction confirmed by drug affinity responsive target stability (DARTS), cellular thermal shift assay (CETSA), and molecular docking. siRNA knockdown, DARTS, CETSA, molecular docking, astrocyte activation assays FASEB journal Medium 40386937
2023 STX7 overexpression reduces seizure susceptibility and alleviated epileptic activity in kainic acid and pentylenetetrazole models; STX7 does not affect neuronal intrinsic excitability but affects the excitation/inhibition ratio by influencing presynaptic GABA neurotransmitter release and inhibitory vesicle density (but not inhibitory synapse density). Overexpression/knockdown in rodent epilepsy models, whole-cell patch-clamp electrophysiology, transmission electron microscopy Neurobiology of disease Medium 37031804
2025 STX7 knockout in hepatocellular carcinoma cells suppresses proliferation, migration, and EMT via inhibition of NF-κB signaling. CRISPR knockout, in vitro proliferation/migration assays, in vivo xenograft, Western blot for NF-κB pathway markers BMC cancer Low 40999361
2024 GORASP2 depletion attenuates assembly of both STX17-SNAP29-VAMP8 and YKT6-SNAP29-STX7 SNARE complexes required for autophagosome-lysosome fusion, placing STX7 downstream of GORASP2-regulated RAB7A-HOPS machinery. Super-resolution microscopy, siRNA depletion, SNARE complex assembly assays Autophagy Low 39056394
2020 A trafficome-wide RNAi screen identified the late endo-/lysosomal SNARE complex STX7/STX8/VTI1B/VAMP7 or VAMP8 as required for Salmonella-induced filament (SIF) formation and intracellular Salmonella replication. Sub-genomic RNAi screen, high-resolution live cell imaging for SIF morphology and dynamics PLoS pathogens Low 32658937
2025 STX7, STX8, and VTI1B are recruited to the Plasmodium parasitophorous vacuole membrane (PVM) ~24 h post-infection; combined knockouts with VAMP7 reveal partial redundancy; STX7/VAMP8 appear at PVM later than VAMP7/Vti1B suggesting a role in nutrient acquisition phase. CRISPR/Cas9 knockout in HeLa cells, confocal microscopy, combinatorial knockout infection assays Cells Low 41972675
2025 STX7, STX8, and VTI1B are required for crinophagy (secretory granule-lysosome fusion) in endocrine cells; siRNA screening identified these SNAREs as necessary for SG-lysosome docking/fusion alongside Munc13-4, Rab27A, VAMP2, PLEKHM1, and HOPS subunits. siRNA screen with live-cell SG-lysosome fusion assay Research square (preprint)preprint Low 40951263

Source papers

Stage 0 corpus · 53 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. The American journal of psychiatry 261 18198266
2018 Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. The Journal of cell biology 194 29789439
2021 TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy. Autophagy 82 33779513
2004 Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. American journal of human genetics 75 15329799
2017 Mfsd2a (Major Facilitator Superfamily Domain Containing 2a) Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Inhibiting Vesicular Transcytosis. Journal of the American Heart Association 70 28724654
2011 Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. Traffic (Copenhagen, Denmark) 54 21388490
2011 Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes. Traffic (Copenhagen, Denmark) 40 21438968
2014 UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proceedings of the National Academy of Sciences of the United States of America 35 24550300
2011 The cystic fibrosis transmembrane conductance regulator's expanding SNARE interactome. Traffic (Copenhagen, Denmark) 29 21223469
2024 Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion. Cell reports 26 38340317
2017 HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication. PLoS pathogens 25 28931085
2007 Identification of novel genes associated with dominant follicle development in cattle. Reproduction, fertility, and development 25 18076829
2025 Identification of immune-inflammation targets for intracranial aneurysms: a multiomics and epigenome-wide study integrating summary-data-based Mendelian randomization, single-cell-type expression analysis, and DNA methylation regulation. International journal of surgery (London, England) 23 39051921
2017 Identification of TWIST-interacting genes in prostate cancer. Science China. Life sciences 21 28120266
2008 Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages. Molecular and cellular biology 21 18710945
2021 The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons. Communications biology 20 34408265
2009 Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma. Journal of proteome research 20 19714869
2021 A Genome-wide Association Study Identifies SERPINB10, CRLF3, STX7, LAMP3, IFNG-AS1, and KRT80 As Risk Loci Contributing to Cutaneous Leishmaniasis in Brazil. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 19 32830257
2021 Proteomic identification of select protein variants of the SNARE interactome associated with cognitive reserve in a large community sample. Acta neuropathologica 19 33646358
2020 A trafficome-wide RNAi screen reveals deployment of early and late secretory host proteins and the entire late endo-/lysosomal vesicle fusion machinery by intracellular Salmonella. PLoS pathogens 18 32658937
2015 γ-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways. Journal of cell science 18 26101353
2020 Enhanced Cd accumulation by Graphene oxide (GO) under Cd stress in duckweed. Aquatic toxicology (Amsterdam, Netherlands) 16 33075615
2019 Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency. Autophagy 16 30892133
2019 Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44. The Biochemical journal 16 31665227
2020 Heat Stress Impairs the Physiological Responses and Regulates Genes Coding for Extracellular Exosomal Proteins in Rat. Genes 15 32183190
2025 Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma. Nature cell biology 13 41315767
2020 PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation. Autophagy 13 33112705
2021 The trans-SNARE complex VAMP4/Stx6/Stx7/Vti1b is a key regulator of Golgi to late endosome MT1-MMP transport in macrophages. Traffic (Copenhagen, Denmark) 12 34476885
2022 Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation. Journal of cell science 11 35762511
2017 Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence. Translational oncology 10 28433799
2024 SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion. The EMBO journal 8 39653855
2023 Establishing Molecular Subgroups of CD8+ T Cell-Associated Genes in the Ovarian Cancer Tumour Microenvironment and Predicting the Immunotherapy Response. Biomedicines 8 37760841
2024 GORASP2 promotes phagophore closure and autophagosome maturation into autolysosomes. Autophagy 7 39056394
2024 The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking. Cell reports 7 39154341
2022 Diesel exhaust particles induce human umbilical vein endothelial cells apoptosis by accumulation of autophagosomes and caspase-8 activation. Scientific reports 6 36192481
2023 Syntaxin 7 modulates seizure activity in epilepsy. Neurobiology of disease 5 37031804
2021 Long Noncoding RNA NTT Context-Dependently Regulates MYB by Interacting With Activated Complex in Hepatocellular Carcinoma Cells. Frontiers in oncology 4 34616668
2024 Identification of the role of SNARE proteins in rAAV vector production through interaction with the viral MAAP. Molecular therapy. Methods & clinical development 3 39807420
2022 In silico analysis of microRNA genes in azoospermia factor Y-chromosome microdeletions. International urology and nephrology 3 35124761
2024 Exploring temporal and sex-linked dysregulation in Alzheimer disease phosphoproteome. iScience 2 39391719
2023 Comparative Hippocampal Proteome and Phosphoproteome in a Niemann-Pick, Type C1 Mouse Model Reveal Insights into Disease Mechanisms. Journal of proteome research 2 37999680
2016 An Immunohistochemical Survey of SNARE Proteins Shows Distinct Patterns of Expression in Hematolymphoid Neoplasia. American journal of clinical pathology 2 27247366
2025 Capsazepine Inhibits Astrocyte Activation and Attenuates Neuroinflammation by Targeting Syntaxin 7. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 40386937
2025 Salmonella Typhimurium Manipulates Syntaxin 7 to Navigate Endo-Lysosomal Trafficking in Host Cells. Traffic (Copenhagen, Denmark) 1 40444290
2025 Proteomic insights into early pancreatic ductal adenocarcinoma biology and screening. Discover oncology 1 40789825
2024 SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion. bioRxiv : the preprint server for biology 1 41030966
2026 Munc13-4-STX7 inhibitors impair endosomal TLR activation and systemic inflammation. Nature chemical biology 0 41942734
2026 Host SNARE Proteins Mediate Lysosome and PVM Fusion to Support Plasmodium Liver Infection. Cells 0 41972675
2025 Molecular requirements for mammalian crinophagy highlight a key role for Ca2+-dependent Munc13-4. Research square 0 40951263
2025 Syntaxin-7 promotes EMT and tumor progression via NF-κB signaling and is associated with macrophage infiltration: pan-cancer analysis and experimental validation in hepatocellular carcinoma. BMC cancer 0 40999361
2024 MicroRNAs correlate with bacillary index and genes associated to cell death processes in leprosy. Microbes and infection 0 38224943
2023 Exploring Temporal and Sex-Linked Dysregulation in Alzheimer's Disease Phospho-Proteome. bioRxiv : the preprint server for biology 0 37645993
2023 Conserved regulation of autophagosome-lysosome fusion through YKT6 phosphorylation. Autophagy reports 0 40395297

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