Affinage

ATP6AP2

Renin receptor · UniProt O75787

Length
350 aa
Mass
39.0 kDa
Annotated
2026-06-09
90 papers in source corpus 12 papers cited in narrative 12 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 4/5 claims corpus-supported (80%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ATP6AP2, also known as the (pro)renin receptor ((P)RR), is a multifunctional membrane protein that couples local renin-angiotensin signalling to vacuolar H⁺-ATPase (V-ATPase) function and developmental/metabolic control (PMID:23844810, PMID:20409904). As an essential V-ATPase accessory protein, it is required for endosomal/lysosomal acidification and lysosomal biogenesis, and its loss compromises autophagy flux [PMID:bio_10.1101_2025.08.26.671788]; this V-ATPase function is also necessary for Wnt3a-driven induction of Tcf/Lef-responsive genes, while full-length (P)RR overexpression represses Wnt signalling through Dvl independently of β-catenin status (PMID:23022225). Distinct from these roles, (P)RR also acts as an adaptor that drives a separate transcriptional programme through the transcription factor PLZF, and knockdown studies resolve the non-overlapping gene sets controlled by its V-ATPase versus PLZF-adaptor functions (PMID:23469216). Binding of prorenin or renin non-proteolytically activates prorenin and triggers angiotensin-II-independent intracellular signalling, with receptor overexpression alone sufficient to cause end-organ renal damage (PMID:20409904). Tissue-specific genetic studies establish physiological roles in energy homeostasis and development: adipose-specific deletion reduces fat mass and improves insulin sensitivity (PMID:27689008), (P)RR is required for trophoblast proliferation, migration, invasion and placental labyrinth development (PMID:37588662), and tubular overexpression produces V-ATPase-dependent hypertension and urinary alkalinization (PMID:35008728).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2008 Medium

    Established that (P)RR is a functional receptor whose ligand binding activates prorenin and drives signalling independent of angiotensin II, and that receptor excess alone causes organ damage — defining (P)RR as more than a passive renin-binding protein.

    Evidence Transgenic rat overexpression, streptozotocin diabetic nephropathy model, and handle-region peptide blockade with renal histopathology

    PMID:20409904

    Open questions at the time
    • Molecular signalling cascade downstream of prorenin binding not resolved
    • Mechanism by which receptor overexpression causes glomerulopathy unclear
  2. 2012 Medium

    Dissected the Wnt-related role, showing (P)RR represses Wnt signalling via Dvl when overexpressed, while its V-ATPase activity (not PLZF or renin activity) is required for Wnt3a-induced Tcf/Lef gene expression — separating its molecular functions in one pathway.

    Evidence Tcf/Lef reporter assays, endogenous axin2 quantification, siRNA knockdown and overexpression in HEK293T and HepG2 cells

    PMID:23022225

    Open questions at the time
    • Structural basis of Dvl interaction not defined
    • Reconciliation of repressor versus required-for-induction roles incomplete
  3. 2013 Medium

    Resolved that the V-ATPase and PLZF-adaptor functions of (P)RR drive distinct, partly overlapping transcriptional programmes, establishing that its molecular roles map onto separable downstream gene networks.

    Evidence siRNA knockdown, PLZF overexpression, microarray and ChIP-chip with pharmacological inhibitors (genistein, bafilomycin) and qPCR validation

    PMID:23469216

    Open questions at the time
    • Direct PLZF target genes not fully validated
    • Cell-type generality of the programmes untested
  4. 2016 High

    Demonstrated a genetic, tissue-autonomous role for (P)RR in energy homeostasis, where adipose deletion reduces adiposity and improves insulin sensitivity — placing (P)RR in metabolic control beyond the cardiovascular system.

    Evidence AP2-Cre conditional knockout mice with metabolic cage, glucose tolerance, plasma insulin/C-peptide, adipocyte histomorphometry and adiponectin assays

    PMID:27689008

    Open questions at the time
    • Which molecular function (V-ATPase vs renin vs Wnt) drives the metabolic phenotype unknown
    • Mechanism linking (P)RR loss to elevated adiponectin not defined
  5. 2021 Medium

    Showed that tubular (P)RR overexpression produces V-ATPase-dependent hypertension and urine alkalinization reversed by bafilomycin, anchoring (P)RR's blood-pressure role to its V-ATPase function in the kidney.

    Evidence Tubular-specific transgenic mice with pharmacological dissection (ARB, renin inhibitor, bafilomycin), urine chemistry and double-transgenic renin crosses

    PMID:35008728

    Open questions at the time
    • Identity of physiological tubular ligand not proven
    • Single-lab transgenic model
  6. 2023 High

    Established a developmental requirement for (P)RR in placentation, where knockdown impairs trophoblast function and disrupts placental labyrinth architecture in vivo.

    Evidence siRNA in HTR-8/SVneo cells with xCELLigence assays plus lentiviral shRNA in mouse blastocysts, embryo transfer and placental stereology

    PMID:37588662

    Open questions at the time
    • Molecular pathway mediating trophoblast effects not identified
    • Relationship to renin/V-ATPase/Wnt functions untested
  7. 2024 Medium

    Linked (P)RR to hepatic lipid metabolism via an ERK/PPARγ axis, with the handle-region peptide reversing lipid accumulation — extending the receptor's signalling output to fatty acid synthesis/transport.

    Evidence SHR model and renin-stimulated HepG2 lipid deposition with HRP blockade, RNA-seq, Nile red staining and western blot for ERK/PPARγ

    PMID:40650317

    Open questions at the time
    • Direct receptor-to-ERK coupling not reconstituted
    • Single-lab evidence
  8. 2025 Medium

    Mechanistically confirmed (P)RR as a Sec61-dependent co-translational substrate required for V-ATPase assembly, lysosomal acidification and autophagy, connecting it to phagocyte antimicrobial function.

    Evidence Mycolactone/Sec61 inhibition with TFEB translocation, lysosomal acidification, autophagy flux and M. ulcerans infection assays (preprint)

    PMID:bio_10.1101_2025.08.26.671788

    Open questions at the time
    • Preprint, single lab
    • Direct structural role within assembled V-ATPase not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the distinct molecular functions of (P)RR — prorenin activation, V-ATPase accessory role, Wnt/Dvl adaptor, and PLZF recruitment — are selected and balanced within a given cell type, and which one drives each tissue phenotype, remains unresolved.
  • No unified model linking molecular functions to specific physiological outputs
  • Ligand selectivity and context-dependent function not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 2 GO:0098772 molecular function regulator activity 2 GO:0060089 molecular transducer activity 1
Localization
GO:0005764 lysosome 1 GO:0005768 endosome 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-382551 Transport of small molecules 2 R-HSA-9612973 Autophagy 1
Partners
ATP6AP1DVLPLZFRENINSEC61
Complex memberships
V-ATPase

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2012 Full-length (P)RR acts as a repressor of Wnt signalling in a system pre-activated by Wnt3a or constitutively active β-catenin; these repressive effects are mediated by Dvl but are independent of β-catenin mutation status. Furthermore, the V-ATPase complex (but not PLZF translocation or renin enzymatic activity) is necessary for induction of Tcf/Lef-responsive genes by Wnt3a. Tcf/Lef reporter gene assay in HEK293T and HepG2 cells; quantification of endogenous axin2 mRNA and protein; siRNA knockdown and stable overexpression constructs Biochemical pharmacology Medium 23022225
2013 siRNA knockdown of (P)RR identified distinct transcriptional signatures downstream of its V-ATPase function versus its PLZF-adaptor function; microarray and ChIP-chip analyses revealed overlapping and non-overlapping genetic programmes controlled by each molecular function of (P)RR, with novel target genes validated by real-time PCR. siRNA knockdown of (P)RR; stable PLZF overexpression; microarray transcriptomics; chromatin immunoprecipitation (ChIP)-chip; PLZF translocation inhibitor genistein; V-ATPase inhibitor bafilomycin; real-time PCR validation PloS one Medium 23469216
2016 Adipose tissue-specific knockout of ATP6AP2/(P)RR (using AP2-Cre) in mice results in lower body weight, reduced fat mass, smaller adipocytes, increased locomotor activity, increased basal metabolic rate (males), improved insulin sensitivity (lower plasma insulin and C-peptide), and elevated circulating adiponectin, establishing a direct role of (P)RR in adipose tissue energy homeostasis and insulin sensitivity. Cre-loxP conditional knockout (AP2-Cre); metabolic cage measurements; glucose tolerance test; plasma insulin and C-peptide; adipocyte histomorphometry; adiponectin ELISA Molecular metabolism High 27689008
2021 Tubular-specific overexpression of (P)RR in transgenic mice causes hypertension and alkalized urine with lower osmolality and Na+ excretion; bafilomycin (V-ATPase antagonist) acidified the urine of these mice, indicating that (P)RR functions as a component of V-ATPase in renal tubules. Cross-breeding with alternative intracellular renin transgenic mice caused lethal renal tubular damage, suggesting intracellular renin is a ligand for tubular (P)RR. Tubular-specific (P)RR transgenic mouse; metabolic cage analysis; ARB, direct renin inhibitor, and bafilomycin pharmacological treatments; urine chemistry; double transgenic cross with alternative renin transgenic mice; histopathology International journal of molecular sciences Medium 35008728
2023 siRNA knockdown of ATP6AP2/(P)RR in the HTR-8/SVneo first-trimester trophoblast cell line impairs trophoblast proliferation, migration, and invasion in vitro; lentiviral shRNA knockdown of (P)RR in mouse blastocyst trophectoderm reduces placental labyrinth trophoblast number and total surface area, increases maternal blood space, and reduces the fetal-placental weight ratio in vivo, establishing a direct functional requirement for (P)RR in placental development. siRNA knockdown in HTR-8/SVneo cells; xCELLigence real-time cell analysis for proliferation, migration, invasion; lentiviral shRNA knockdown in mouse blastocysts; in vivo embryo transfer; stereological Merz grid analysis of placental compartments Frontiers in cell and developmental biology High 37588662
2008 Binding of prorenin or renin to (P)RR non-proteolytically activates prorenin and stimulates receptor-mediated intracellular signalling independent of angiotensin II; transgenic rats overexpressing (P)RR develop renal glomerulopathy without elevation of blood glucose or blood pressure, indicating that (P)RR overexpression alone is sufficient for end-organ damage. A peptidic (P)RR blocker (handle-region peptide) prevents diabetic nephropathy and attenuates hypertensive cardiomyopathy/nephropathy. Transgenic rat overexpression; streptozotocin diabetic nephropathy model; chronic infusion of handle-region peptide blocker; renal histopathology; blood pressure and metabolic measurements Journal of the American Society of Hypertension : JASH Medium 20409904
2014 (P)RR acts as an essential accessory protein of vacuolar H+-ATPase (V-ATPase) and also as an adaptor protein of Wnt signalling, in addition to its role as a receptor that non-proteolytically activates prorenin to catalyse angiotensinogen-to-angiotensin I conversion. Review synthesising in vivo and in vitro experimental evidence including receptor binding assays, V-ATPase assembly studies, and Wnt reporter assays from prior experimental work Current pharmaceutical design Low 23844810
2024 (P)RR overexpression activates the (P)RR/ERK/PPARγ signalling axis and downstream proteins related to fatty acid synthesis and transport in liver, promoting lipid accumulation; the handle-region peptide (HRP) blocker reverses activation of these proteins and reduces intracellular lipid accumulation in renin-stimulated HepG2 cells and in spontaneously hypertensive rats. SHR animal model; HepG2 cell lipid deposition model induced by renin; HRP pharmacological blockade; RNA sequencing; liver H&E and Nile red fluorescence staining; western blot for (P)RR, ERK, PPARγ, and lipid metabolism proteins; immunofluorescence International journal of molecular sciences Medium 40650317
2024 In vascular plaques, ELABELA-21 treatment reduces PRR (ATP6AP2) protein expression and decreases plasma soluble (P)RR levels, while the APJ inhibitor ML221 further elevates ATP6AP2 mRNA in THP-1 cells, placing (P)RR downstream of APJ-mediated signalling in macrophage inflammation and atherosclerotic plaque biology. ApoE−/− high-fat diet mouse model; ELA-21 administration; immunohistochemistry/protein expression in plaques; plasma sPRR ELISA; in vitro THP-1 foam cell and M1 polarization assays with APJ inhibitor; mRNA quantification bioRxiv (preprint)preprint Low bio_10.1101_2024.11.07.24316940
2025 Mycolactone-mediated Sec61 inhibition causes loss of ATP6AP1 and ATP6AP2 (both Sec61-dependent co-translational substrates), which are required for Vacuolar-ATPase assembly; loss of these proteins leads to reduced lysosomal biogenesis and acidification, compromising autophagy flux and the ability of phagocytes to combat M. ulcerans infection. Mycolactone treatment of cells; Sec61 inhibition; TFEB nuclear translocation assay; lysosomal biogenesis and acidification assays; autophagy flux measurements; infection assays with M. ulcerans bioRxiv (preprint)preprint Medium bio_10.1101_2025.08.26.671788
2025 Single-nucleus RNA sequencing of mouse hypothalamic paraventricular nucleus (PVN) shows that Atp6ap2/(P)RR is predominantly expressed in neurons (not astrocytes); DOCA-salt hypertension increases neuronal Atp6ap2 expression, and high-fat diet upregulates Atp6ap2 in vasopressin neurons, indicating cell-type-specific regulation of (P)RR under cardiometabolic stress. Single-nucleus RNA sequencing (snRNA-seq) of PVN from baseline, DOCA-salt hypertension, and high-fat diet mouse models; cell-type-specific gene expression analysis bioRxiv (preprint)preprint Low bio_10.1101_2025.08.14.669892
2024 (P)RR/(ATP6AP2) is required in cardiovascular tissues for canonical Wnt transduction: offspring of preeclamptic rats show elevated (P)RR expression together with upregulation of PLZF, β-catenin, DVL-1, and PKCα in heart, aorta, and kidney; handle-region peptide treatment abolishes these increases and reverses hypertension, placing (P)RR upstream of canonical Wnt pathway components in cardiovascular regulation. Preeclampsia rat offspring model; HRP pharmacological treatment; immunoblot for (P)RR, PLZF, β-catenin, DVL-1, PKCα; RT-PCR for (P)RR and PLZF; blood pressure measurement; morphological organ assessment Iranian journal of basic medical sciences Low 38629095

Source papers

Stage 0 corpus · 90 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice. Toxicology 326 12767698
2007 RR interval variability is inversely related to inflammatory markers: the CARDIA study. Molecular medicine (Cambridge, Mass.) 178 17592552
2022 The CAR-HEMATOTOX risk-stratifies patients for severe infections and disease progression after CD19 CAR-T in R/R LBCL. Journal for immunotherapy of cancer 167 35580927
2022 Follow-up of patients with R/R FLT3-mutation-positive AML treated with gilteritinib in the phase 3 ADMIRAL trial. Blood 120 35081255
2023 Detailed safety profile of acalabrutinib vs ibrutinib in previously treated chronic lymphocytic leukemia in the ELEVATE-RR trial. Blood 101 37390310
1995 Transposon-mediated chromosomal rearrangements and gene duplications in the formation of the maize R-r complex. The EMBO journal 89 7774593
2004 Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition. The Journal of pharmacology and experimental therapeutics 82 15306635
1991 Meiotic instability of the R-r complex arising from displaced intragenic exchange and intrachromosomal rearrangement. Genetics 63 1682214
1992 Changes in R-R interval at the start of muscle contraction in the decerebrate cat. The Journal of physiology 59 1593459
2009 A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. Circulation. Cardiovascular genetics 57 20031603
2007 Analytical and functional characterization of microcystins [Asp3]MC-RR and [Asp3,Dhb7]MC-RR: consequences for risk assessment? Environmental science & technology 53 17438823
2008 Acute effects of microcystins MC-LR and MC-RR on acid and alkaline phosphatase activities and pathological changes in intraperitoneally exposed tilapia fish (Oreochromis sp.). Toxicologic pathology 44 18441257
2023 Safety and efficacy of tisagenlecleucel plus pembrolizumab in patients with r/r DLBCL: phase 1b PORTIA study results. Blood advances 43 36044388
2015 Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signaling in the dorsal horn of the spinal cord. Pharmacology research & perspectives 38 26171221
2023 Nivolumab combined with brentuximab vedotin for R/R primary mediastinal large B-cell lymphoma: a 3-year follow-up. Blood advances 33 37352266
1998 Contributions of tidal lung inflation to human R-R interval and arterial pressure fluctuations. Journal of the autonomic nervous system 33 9531448
2000 The thylakoid delta pH-dependent pathway machinery facilitates RR-independent N-tail protein integration. The Journal of biological chemistry 32 10816594
2021 Anti-CD19 CAR-T cell therapy bridge to HSCT decreases the relapse rate and improves the long-term survival of R/R B-ALL patients: a systematic review and meta-analysis. Annals of hematology 31 33587155
2012 The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR. Proteomics 31 22140076
2022 The differential effects of tumor burdens on predicting the net benefits of ssCART-19 cell treatment on r/r B-ALL patients. Scientific reports 30 35013456
2016 Adipose tissue (P)RR regulates insulin sensitivity, fat mass and body weight. Molecular metabolism 30 27689008
1999 Characterization of the regulatory elements of the maize P-rr gene by transient expression assays. Plant molecular biology 30 10080705
1996 PR/RR interval ratio during rapid atrial pacing: a simple method for confirming the presence of slow AV nodal pathway conduction. Journal of cardiovascular electrophysiology 27 8777476
2022 Timing of Tocilizumab Administration Under the Guidance of IL-6 in CAR-T Therapy for R/R Acute Lymphoblastic Leukemia. Frontiers in immunology 26 35799791
2012 The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signalling. Biochemical pharmacology 25 23022225
2006 Association of decreased variation of R-R interval and elevated serum C-reactive protein level in a general population in Japan. International heart journal 24 17268121
1991 The alpha- and beta-adrenoceptor blocking activities of labetalol and its RR-SR (50:50) stereoisomers. British journal of pharmacology 21 1687367
2000 Generation of antibodies directed against the low-immunogenic peptide-toxins microcystin-LR/RR and nodularin. International journal of immunopharmacology 20 10708882
2018 Allogeneic hematopoietic stem cell transplantation in r/r Hodgkin lymphoma after treatment with checkpoint inhibitors: Feasibility and safety. European journal of haematology 18 30341987
2017 Hepatotoxicity and metabolic effects of cellular extract of cyanobacterium Radiocystis fernandoi containing microcystins RR and YR on neotropical fish (Hoplias malabaricus). Chemosphere 17 28242458
1990 Effects of carbonyl cyanide p-trichloromethoxyphenylhydrazone (CCCP) and of ruthenium red (RR) on capsaicin-evoked neuropeptide release from peripheral terminals of primary afferent neurones. Naunyn-Schmiedeberg's archives of pharmacology 17 1697404
2025 Impact of vein-to-vein time in patients with R/R LBCL treated with axicabtagene ciloleucel. Blood advances 16 39883946
2022 High proportion of RR-TB and mutations conferring RR outside of the RRDR of the rpoB gene detected in GeneXpert MTB/RIF assay positive pulmonary tuberculosis cases, in Addis Ababa, Ethiopia. PloS one 16 36584037
2021 Serial surveillance by circulating tumor DNA profiling after chimeric antigen receptor T therapy for the guidance of r/r diffuse large B cell lymphoma precise treatment. Journal of Cancer 16 34405005
1991 Leucine repeats in the large subunit of herpes simplex virus type 2 ribonucleotide reductase (RR; ICP10) are involved in RR activity and subunit complex formation. The Journal of general virology 16 1851814
2025 Real-world data for tisagenlecleucel in patients with R/R B-ALL: subgroup analyses from the CIBMTR registry. Blood advances 15 40554426
2024 OUTREACH: phase 2 study of lisocabtagene maraleucel as outpatient or inpatient treatment at community sites for R/R LBCL. Blood advances 14 39347584
2023 Salvage therapy with brentuximab-vedotin and bendamustine for patients with R/R PTCL: a retrospective study from the LYSA group. Blood advances 14 36477770
2014 Draft Genome Sequence of Phaeomoniella chlamydospora Strain RR-HG1, a Grapevine Trunk Disease (Esca)-Related Member of the Ascomycota. Genome announcements 14 24723699
1984 Antitumor activity and toxicity in animals of RR-150 (7-cysteaminomitosane), a new mitomycin derivative. Cancer research 14 6437670
2013 Appearance of Planktothrix rubescens bloom with [D-Asp3, Mdha7]MC-RR in gravel pit pond of a shallow lake-dominated area. Toxins 13 24351711
2012 Genotype- and Sex-Specific QT-RR Relationship in the Type-1 Long-QT Syndrome. Journal of the American Heart Association 12 23130128
2007 Identifying coronary artery flow reduction and ischemia using quasistationary QT/RR-interval hysteresis measurements. Journal of electrocardiology 11 17993337
1991 Pre-excited RR intervals during atrial fibrillation in the Wolff-Parkinson-White syndrome: influence of the atrioventricular node refractory period. Journal of the American College of Cardiology 11 1960320
2017 Cannabinoid receptor 2-63 RR variant is independently associated with severe necroinflammation in HIV/HCV coinfected patients. PloS one 10 28759568
2016 A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Journal of medical genetics 10 28039329
2025 Efficacy of zanubrutinib versus acalabrutinib for relapsed or refractory chronic lymphocytic leukemia (R/R CLL): a matching-adjusted indirect comparison (MAIC). Therapeutic advances in medical oncology 9 40656602
2008 Growth-compromised HSV-2 vector Delta RR protects from N-methyl-D-aspartate-induced neuronal degeneration through redundant activation of the MEK/ERK and PI3-K/Akt survival pathways, either one of which overrides apoptotic cascades. Journal of neuroscience research 9 17893911
2025 Lisocabtagene maraleucel for R/R LBCL in patients not intended for HSCT: final results of the phase 2 PILOT study. Blood advances 8 40305658
2024 Comparative efficacy and safety of tisagenlecleucel and axicabtagene ciloleucel among adults with r/r follicular lymphoma. Leukemia & lymphoma 8 38179688
2024 Improved efficacy and safety of zanubrutinib versus ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL) in China: a subgroup of ALPINE. Annals of hematology 8 38888616
2022 Transcriptome-Wide Identification of CCCH-Type Zinc Finger Proteins Family in Pinus massoniana and RR-TZF Proteins in Stress Response. Genes 8 36140811
2024 Daratumumab and venetoclax combined with CAGE for late R/R T-ALL/LBL patients: Single-arm, open-label, phase I study. Annals of hematology 7 38662205
2021 Blood Pressure Elevation of Tubular Specific (P)RR Transgenic Mice and Lethal Tubular Degeneration due to Possible Intracellular Interactions between (P)RR and Alternative Renin Products. International journal of molecular sciences 7 35008728
2018 In vivo evidence that the cannabinoid receptor 2-63 RR variant is associated with the acquisition and/or expansion of HIV infection. HIV medicine 7 29932291
2000 Multiple AV nodal pathways with multiple peaks in the RR interval histogram of the Holter monitoring ECG during atrial fibrillation. Pacing and clinical electrophysiology : PACE 7 11139958
2024 Genome-wide characterization of RR gene family members in Zanthoxylum armatum and the subsequent functional characterization of the C-type RR. Plant physiology and biochemistry : PPB 6 39032447
2023 Placental deficiency of the (pro)renin receptor ((P)RR) reduces placental development and functional capacity. Frontiers in cell and developmental biology 6 37588662
2013 Distinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses. PloS one 6 23469216
2025 Tocilizumab Dosing for Management of T Cell-Engaging Bispecific Antibody-Related CRS in Patients With R/R B-Cell NHL. Clinical pharmacology and therapeutics 5 40576759
2024 Rituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion. Cellular oncology (Dordrecht, Netherlands) 5 38662336
2024 Efficacy and safety of bendamustine-containing bridging therapy in R/R LBCL patients receiving CD19 CAR T-cells. HemaSphere 5 38948924
2024 Outcomes of patients with R/R B-cell NHL and limited (<5 sites) pre-CART disease bridged with or without radiotherapy. Blood advances 5 39028948
2021 The (pro)renin receptor ((P)RR) and soluble (pro)renin receptor (s(P)RR) in pregnancy. Placenta 5 34020806
2017 Phase 2 trial of sunitinib and gemcitabine in patients with sarcomatoid and/or poor-risk metastatic renal cell carcinoma. Michaelson MD, McKay RR, Werner L, Atkins MB, Van Allen EM, Olivier KM, Song J, Signoretti S, McDermott DF, Choueiri TK.Cancer. 2015 Oct 1;121(19):3435-43. [Epub 2015 Jun 8]. doi: 10.1002/cncr.29503. Urologic oncology 5 28159495
2025 The dual role of the RR-2 cuticular protein gene in development and acaricide susceptibility of Panonychus citri (Acari: Tetranychidae). Experimental & applied acarology 4 40423860
2025 Population-based validation of the CAR-HEMATOTOX for hematotoxicity, infections, and survival after CART in R/R LBCL. Blood advances 4 40668622
2021 Characteristics of the Dynamic Electrocardiogram in the Elderly with Nonvalvular Atrial Fibrillation Combined with Long R-R Intervals. Evidence-based complementary and alternative medicine : eCAM 4 34804179
2008 Renin/prorenin receptor, (P)RR, in end-organ damage: current issues in 2007. Journal of the American Society of Hypertension : JASH 4 20409904
2001 LFA-1 expression on CD4(+)CD45RO(+) peripheral blood T-lymphocytes in RR MS: effects induced by rIFNbeta-1a. Journal of the neurological sciences 4 11412874
2014 Novel approach to cardiovascular diseases: a promising probability of (pro)renin receptor [(P)RR]. Current pharmaceutical design 3 23844810
2025 Pirtobrutinib, a highly selective, noncovalent (reversible) BTKi in R/R follicular lymphoma: phase 1/2 BRUIN study. Blood advances 2 40845254
2024 PKM2/Hif-1α signal suppression involved in therapeutics of pulmonary fibrosis with microcystin-RR but not with pirfenidone. Toxicon : official journal of the International Society on Toxinology 2 38908528
2024 Efficacy and Safety of Ibrutinib as Monotherapy or Combination Therapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL): A Systematic Review and Meta-analysis. American journal of therapeutics 2 39413356
2024 Microcystin-RR is a biliary toxin selective for neonatal extrahepatic cholangiocytes. JHEP reports : innovation in hepatology 2 39687604
2008 The RR genotype of codon 72 of p53 gene reduces the development of intestinal metaplasia. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2 18567547
2025 QT and RR interval analysis in genetic cardiac diseases using the AccuQT and advanced heart rate variability methods. Journal of electrocardiology 1 40915048
2025 First-line lenvatinib and sorafenib in RR-DTC from a shared real-life context. Endocrine-related cancer 1 41051352
2024 Early evaluation of CAR-T cell therapy response in R/R DLBCL patients using 18F-FDG PET/CT. Hellenic journal of nuclear medicine 1 38629814
2023 Narrow QRS Complex Tachycardia With Variable R-R Intervals and Discrete P Waves. JACC. Case reports 1 36974046
2019 Prediction of bortezomib-induced peripheral neuropathy with the R-R interval variation of the electrocardiogram in plasma cell myeloma: a retrospective study. Leukemia & lymphoma 1 31642372
2026 Pirtobrutinib, a highly selective, noncovalent (reversible) BTKi in R/R marginal zone lymphoma: phase 1/2 BRUIN study. Blood advances 0 41544219
2026 Limited contribution of compensatory mutations to MDR/RR-TB clustering in Hunan Province, China: a population-based whole-genome sequencing study. Microbiology spectrum 0 41773868
2026 Outcomes of patients over 70 years treated with brexu-cel for R/R mantle cell lymphoma: a study from the CTIWP of EBMT. Blood advances 0 41779968
2025 Indirect Comparisons of Efficacy of Zanubrutinib Versus Orelabrutinib in Patients with R/R MCL: An Extended Follow-up Analysis. Advances in therapy 0 40317419
2025 Overexpression of (P)RR in SHR and Renin-Induced HepG2 Cells Leads to Spontaneous Hypertension Combined with Metabolic Dysfunction-Associated Fatty Liver Disease. International journal of molecular sciences 0 40650317
2025 Immune reconstitution after CD7 CAR-T cell therapy for refractory/relapsed acute T-lymphoblastic leukaemia/lymphoblastic lymphoma (R/R T-ALL/LBL). British journal of haematology 0 41111252
2024 Cardiovascular effect of preeclampsia upon offspring development: Are (Pro) renin-renin receptor ((P)RR) and gender related? Iranian journal of basic medical sciences 0 38629095
2024 Soluble (pro)renin receptor (s(P)RR) levels in women carrying Aboriginal and/or Torres Strait Islander babies; the Gomeroi Gaaynggal study. Pregnancy hypertension 0 39577063
2014 [Isolation and cultivation of a wild microcytin-RR-producing cyanobacterium and verification of its toxin by high performance liquid chromatography and acute oral toxicity]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 0 25312573

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