Affinage

ATP6V1E1

V-type proton ATPase subunit E 1 · UniProt P36543

Round 2 corrected
Length
226 aa
Mass
26.1 kDa
Annotated
2026-04-28
128 papers in source corpus 7 papers cited in narrative 7 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ATP6V1E1 encodes the E1 subunit of the peripheral V1 catalytic domain of the vacuolar H⁺-ATPase (V-ATPase), functioning as an essential structural component required for V1 domain assembly onto the V0 membrane sector and for ATPase-driven proton pumping (PMID:8416931, PMID:28065471). ATP6V1E1 directly binds the glycolytic enzyme aldolase, coupling glycolytic flux to V-ATPase activity, as loss of aldolase causes V1–V0 dissociation (PMID:11399750). The V-ATPase complex participates in amino acid sensing at the lysosomal surface through regulated interactions with the Ragulator complex, enabling mTORC1 activation (PMID:22053050), and ATP6V1E1 is subject to BMX-mediated phosphorylation at Tyr56/57, which inhibits V-ATPase assembly and lysosomal acidification—a mechanism exploited by Mycobacterium tuberculosis to promote intracellular survival (PMID:41651829). Biallelic loss-of-function mutations in ATP6V1E1 disrupt V-ATPase complex stability and vesicular trafficking, causing autosomal-recessive cutis laxa with cardiopulmonary involvement (PMID:28065471).

Mechanistic history

Synthesis pass · year-by-year structured walk · 5 steps
  1. 1993 High

    Establishing that the E subunit is indispensable for V-ATPase function resolved a fundamental question about V1 domain assembly: deletion of the yeast ortholog VMA4 prevented V1 attachment to the vacuolar membrane and abolished ATPase activity.

    Evidence Genetic knockout of VMA4 in S. cerevisiae with biochemical fractionation and ATPase assays

    PMID:8416931

    Open questions at the time
    • Mammalian E1 subunit function not yet directly tested
    • Mechanism by which E subunit promotes V1–V0 assembly unknown
    • No structural model of E subunit within the holoenzyme
  2. 2001 High

    Discovery that ATP6V1E1 directly binds aldolase established an unexpected physical link between glycolysis and V-ATPase proton pumping, answering how metabolic status could regulate vacuolar acidification.

    Evidence Yeast two-hybrid, GST pulldown, co-immunoprecipitation from bovine kidney, and aldolase-deficient yeast showing V1 dissociation

    PMID:11399750

    Open questions at the time
    • Binding interface between E subunit and aldolase not mapped
    • Whether the interaction is regulated by glycolytic intermediates is untested
    • Relevance in mammalian tissues beyond kidney and osteoclasts not examined
  3. 2011 High

    Demonstrating that V-ATPase engages the Ragulator complex in an amino acid–sensitive manner placed the entire complex—including ATP6V1E1—as a lysosomal nutrient sensor upstream of mTORC1, answering how intraluminal amino acids are communicated to cytoplasmic signaling.

    Evidence RNAi knockdown, cell-free reconstitution, co-immunoprecipitation, and mTORC1 translocation imaging in mammalian cells

    PMID:22053050

    Open questions at the time
    • Specific contribution of ATP6V1E1 versus other V1 subunits in Ragulator binding not delineated
    • How ATP hydrolysis modulates Ragulator interaction mechanistically is unclear
    • Whether V-ATPase–Ragulator interaction is tissue-specific is unexplored
  4. 2017 High

    Identification of biallelic ATP6V1E1 mutations causing autosomal-recessive cutis laxa directly linked this subunit to human disease, showing that impaired V-ATPase assembly disrupts vesicular trafficking, elastic fiber formation, and collagen organization.

    Evidence Whole-exome sequencing, complexome profiling (BN-PAGE + LC-MS/MS), brefeldin A trafficking assays, and TEM in patient-derived cells

    PMID:28065471

    Open questions at the time
    • Precise structural consequences of each pathogenic substitution on inter-subunit contacts not resolved at atomic level
    • Whether residual V-ATPase activity correlates with clinical severity is unknown
    • Rescue experiments (e.g., wild-type complementation in patient cells) not reported
  5. 2026 High

    Identification of BMX-mediated phosphorylation at Tyr56/57 of ATP6V1E1 revealed a specific post-translational switch that inhibits V-ATPase assembly, answering how a host kinase can be co-opted by M. tuberculosis (via Chp2) to suppress lysosomal acidification and promote intracellular survival.

    Evidence Co-immunoprecipitation, Tyr56/57 site-directed mutagenesis, lysosomal acidification assays, BMX inhibitor treatment, and in vivo mouse infection model

    PMID:41651829

    Open questions at the time
    • Whether BMX phosphorylation of ATP6V1E1 occurs under non-infectious physiological conditions is untested
    • Structural basis for how Tyr56/57 phosphorylation disrupts V1–V0 assembly not determined
    • Whether other kinases target the same residues is unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis for ATP6V1E1's dual roles—as a V1 assembly scaffold and as a metabolic/signaling integrator (via aldolase and Ragulator interactions)—remains unresolved, and how post-translational regulation at Tyr56/57 is integrated with the reversible V1–V0 dissociation cycle under normal physiology is unknown.
  • No high-resolution structure of ATP6V1E1 in complex with aldolase or BMX
  • Tissue-specific functions of E1 versus the E2 paralog are poorly defined
  • Quantitative contribution of Tyr56/57 phosphorylation to V-ATPase regulation outside infection is untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 2 GO:0140657 ATP-dependent activity 2
Localization
GO:0005764 lysosome 2 GO:0005773 vacuole 1 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-382551 Transport of small molecules 3 R-HSA-1643685 Disease 2 R-HSA-1430728 Metabolism 1 R-HSA-162582 Signal Transduction 1
Partners
ALDOABMXRAGULATOR
Complex memberships
V-ATPase (V1 peripheral domain)

Evidence

Reading pass · 7 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1993 The VMA4 gene of Saccharomyces cerevisiae encodes the 27-kDa subunit of the vacuolar H(+)-ATPase (ortholog of ATP6V1E1/E subunit). Deletion of VMA4 prevents assembly of the peripheral V1 domain onto the vacuolar membrane and abolishes ATPase activity, demonstrating that the E subunit is essential for V-ATPase assembly and function. Genetic deletion (vma4 null mutant), biochemical fractionation, ATPase activity assay The Journal of biological chemistry High 8416931
1995 The Neurospora crassa vma-4 gene encodes a 25.7 kDa subunit of the vacuolar ATPase (ortholog of ATP6V1E1). Sequence analysis and secondary structure prediction indicate this subunit plays the same structural role in V-ATPase as the gamma-subunit does in F-type ATPases, suggesting a conserved structural function in the rotary mechanism. Gene cloning, sequence analysis, comparative secondary structure prediction Biochimica et biophysica acta Medium 7619848
2001 The V-ATPase E subunit directly interacts with aldolase (a glycolytic enzyme). This interaction was identified by yeast two-hybrid screening with the E subunit as bait, confirmed by GST pulldown with E subunit fusion proteins and metabolically labeled aldolase, and validated by co-immunoprecipitation from bovine kidney microsomes and osteoclasts using an anti-E subunit antibody. In yeast lacking aldolase, the V1 domain dissociates from V0, suggesting the E subunit-aldolase interaction couples glycolysis directly to V-ATPase proton pumping. Yeast two-hybrid, GST pulldown, co-immunoprecipitation, yeast aldolase-deficient mutant analysis The Journal of biological chemistry High 11399750
2017 Biallelic missense mutations in ATP6V1E1 (encoding the E1 subunit of the V1 domain of V-ATPase) cause autosomal-recessive cutis laxa with dysmorphic features and cardiopulmonary involvement. Structural modeling showed all substitutions affect critical residues and inter- or intra-subunit interactions. Complexome profiling (blue-native PAGE combined with LC-MS/MS) demonstrated that the mutations disturb either assembly or stability of the V-ATPase complex. Patient cells showed abnormal vesicular trafficking (delayed retrograde transport after brefeldin A, Golgi fragmentation) and reduced/fragmented elastic fibers with abnormal collagen organization. Whole-exome sequencing, structural modeling, complexome profiling (BN-PAGE + LC-MS/MS), brefeldin A trafficking assay, transmission electron microscopy American journal of human genetics High 28065471
2011 The vacuolar H(+)-ATPase (V-ATPase, of which ATP6V1E1/E1 is a subunit) is required for amino acid-dependent activation of mTORC1. The v-ATPase engages in amino acid-sensitive interactions with the Ragulator complex on the lysosomal surface, and ATP hydrolysis by the v-ATPase is necessary for amino acids to regulate the v-ATPase–Ragulator interaction and promote mTORC1 translocation to the lysosome. RNAi knockdown, cell-free reconstitution system, co-immunoprecipitation, mTORC1 translocation imaging Science High 22053050
2026 Mycobacterium tuberculosis secreted protein Rv1184 (Chp2) promotes intracellular bacterial survival by targeting ATP6V1E1. Phosphorylation of ATP6V1E1 at Tyr56/57 by tyrosine kinase BMX suppresses lysosomal acidification through inhibition of V-ATPase assembly. Chp2 directly binds ATP6V1E1 and facilitates its interaction with BMX, increasing BMX-dependent phosphorylation of ATP6V1E1. Inhibition of BMX impaired Mtb growth in macrophages and in mice. Co-immunoprecipitation, site-directed mutagenesis (Tyr56/57), lysosomal acidification assay, BMX inhibitor treatment, in vivo mouse infection model Nature communications High 41651829
2024 ATP6V1E1 knockdown in hepatocellular carcinoma cells markedly inhibited cell proliferation, establishing a functional role for ATP6V1E1 in supporting HCC cell growth. siRNA knockdown, cell proliferation assay (in vitro) Journal of cellular and molecular medicine Low 39294741

Source papers

Stage 0 corpus · 128 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2011 mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (New York, N.Y.) 1323 22053050
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2002 The vacuolar (H+)-ATPases--nature's most versatile proton pumps. Nature reviews. Molecular cell biology 961 11836511
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 Large-scale proteomics and phosphoproteomics of urinary exosomes. Journal of the American Society of Nephrology : JASN 607 19056867
1997 Structure, function and regulation of the vacuolar (H+)-ATPase. Annual review of cell and developmental biology 488 9442887
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
1999 Vacuolar and plasma membrane proton-adenosinetriphosphatases. Physiological reviews 348 10221984
2007 Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation. Cell 307 17662945
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
2011 A directed protein interaction network for investigating intracellular signal transduction. Science signaling 258 21900206
1999 Structure and properties of the vacuolar (H+)-ATPases. The Journal of biological chemistry 252 10224039
2009 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Journal of proteome research 237 19199708
2014 Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. Journal of proteomics 215 25281560
1999 Animal plasma membrane energization by proton-motive V-ATPases. BioEssays : news and reviews in molecular, cellular and developmental biology 206 10440860
2018 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nature communications 201 29568061
1997 The vacuolar H+-ATPase: a universal proton pump of eukaryotes. The Biochemical journal 199 9210392
1983 A hepatitis B surface antigen polypeptide (P31) with the receptor for polymerized human as well as chimpanzee albumins. Gastroenterology 185 6305755
2004 Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. The EMBO journal 169 15257285
1986 Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor. Biochimie 169 2874839
2007 Integral and associated lysosomal membrane proteins. Traffic (Copenhagen, Denmark) 163 17897319
2020 AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System. Molecular cell 152 31995728
2000 The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. The Journal of biological chemistry 150 10915794
2001 Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. The Journal of biological chemistry 146 11399750
1988 Synthesis of functional mouse cytochromes P-450 P1 and chimeric P-450 P3-1 in the yeast Saccharomyces cerevisiae. Gene 139 3044926
1987 Sporulation-specific sigma factor sigma 29 of Bacillus subtilis is synthesized from a precursor protein, P31. Proceedings of the National Academy of Sciences of the United States of America 135 3104904
1993 Isolation of vacuolar membrane H(+)-ATPase-deficient yeast mutants; the VMA5 and VMA4 genes are essential for assembly and activity of the vacuolar H(+)-ATPase. The Journal of biological chemistry 112 8416931
2009 Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa. Gut 109 19951908
2014 Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet). Proceedings of the National Academy of Sciences of the United States of America 108 25092294
2017 Mutations in ATP6V1E1 or ATP6V1A Cause Autosomal-Recessive Cutis Laxa. American journal of human genetics 86 28065471
2011 Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR. Oncogene 67 21602892
2018 Characterization of a Pyrethroid-Degrading Pseudomonas fulva Strain P31 and Biochemical Degradation Pathway of D-Phenothrin. Frontiers in microbiology 64 29867894
1995 Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms. Immunity 61 7553001
1989 Human neoplasm pH and response to radiation therapy: P-31 MR spectroscopy studies in situ. Radiology 57 2916046
2010 Gliadin peptide P31-43 localises to endocytic vesicles and interferes with their maturation. PloS one 54 20805894
2011 p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment. Molecular biology of the cell 52 21965286
2007 RNA4-encoded p31 of beet necrotic yellow vein virus is involved in efficient vector transmission, symptom severity and silencing suppression in roots. The Journal of general virology 48 17412994
2019 p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine. Frontiers in immunology 46 30761127
2020 Mitotic slippage is determined by p31comet and the weakening of the spindle-assembly checkpoint. Oncogene 42 32029899
1979 A tdic(5;15)(p31;p11) chromosome showing variation for constriction in the centromeric regions in a patient with the cri du chat syndrome. Cytogenetics and cell genetics 41 456039
1992 Quantitative P-31 MR spectroscopy of the liver in alcoholic cirrhosis. Journal of magnetic resonance imaging : JMRI 40 1562769
2016 Mechanisms of innate immune activation by gluten peptide p31-43 in mice. American journal of physiology. Gastrointestinal and liver physiology 39 27151946
2018 P31-43, an undigested gliadin peptide, mimics and enhances the innate immune response to viruses and interferes with endocytic trafficking: a role in celiac disease. Scientific reports 38 30018339
2002 Prediction of treatment response of head and neck cancers with P-31 MR spectroscopy from pretreatment relative phosphomonoester levels. Academic radiology 33 12061743
1986 Synthesis in yeast of hepatitis B virus surface antigen modified P31 particles by gene modification. Biochemical and biophysical research communications 32 3028394
2020 p31comet promotes homologous recombination by inactivating REV7 through the TRIP13 ATPase. Proceedings of the National Academy of Sciences of the United States of America 30 33051298
2018 Prevention of Type 1 Diabetes with Acetalated Dextran Microparticles Containing Rapamycin and Pancreatic Peptide P31. Advanced healthcare materials 30 30051618
2011 Chromosome 1p32-p31 deletion syndrome: prenatal diagnosis by array comparative genomic hybridization using uncultured amniocytes and association with NFIA haploinsufficiency, ventriculomegaly, corpus callosum hypogenesis, abnormal external genitalia, and intrauterine growth restriction. Taiwanese journal of obstetrics & gynecology 29 22030051
2008 Identification of a genetic locus for autosomal dominant disseminated superficial actinic porokeratosis on chromosome 1p31.3-p31.1. Human genetics 28 18443824
1986 Expression of hepatitis B virus surface antigen P31 gene in yeast. Biochemical and biophysical research communications 28 2427075
2009 p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival. Molecular and cellular biology 27 19188447
1995 Isolation of the vma-4 gene encoding the 26 kDa subunit of the Neurospora crassa vacuolar ATPase. Biochimica et biophysica acta 26 7619848
2008 Array-CGH in a series of 30 patients with mental retardation, dysmorphic features, and congenital malformations detected an interstitial 1p22.2-p31.1 deletion in a patient with features overlapping the Goldenhar syndrome. American journal of medical genetics. Part A 25 18629884
2022 Gliadin Peptide P31-43 Induces mTOR/NFkβ Activation and Reduces Autophagy: The Role of Lactobacillus paracasei CBA L74 Postbiotc. International journal of molecular sciences 22 35409015
1996 Expression of early lung cancer detection marker p31 in neoplastic and non-neoplastic respiratory epithelium. Lung cancer (Amsterdam, Netherlands) 22 8696723
2019 Structural conformation and self-assembly process of p31-43 gliadin peptide in aqueous solution. Implications for celiac disease. The FEBS journal 21 31659864
2013 A celiac cellular phenotype, with altered LPP sub-cellular distribution, is inducible in controls by the toxic gliadin peptide P31-43. PloS one 21 24278174
2012 Role of phosphorylation of Cdc20 in p31(comet)-stimulated disassembly of the mitotic checkpoint complex. Proceedings of the National Academy of Sciences of the United States of America 21 22566641
2017 Loss-of-function variants in NFIA provide further support that NFIA is a critical gene in 1p32-p31 deletion syndrome: A four patient series. American journal of medical genetics. Part A 20 28941020
2014 Infection of Beet necrotic yellow vein virus with RNA4-encoded P31 specifically up-regulates pathogenesis-related protein 10 in Nicotiana benthamiana. Virology journal 20 24961274
2001 Immunization with plasmid DNA encoding MHC class II binding peptide/CLIP-replaced invariant chain (Ii) induces specific helper T cells in vivo: the assessment of Ii p31 and p41 isoforms as vehicles for immunization. Vaccine 19 11567753
1991 P-31 spectroscopy study of response of superficial human tumors to therapy. Radiology 19 2006266
1990 P-31 NMR analysis of phospholipids from cultured human corneal epithelial, fibroblast and endothelial cells. Current eye research 19 2091896
2019 Structural insights on P31-43, a gliadin peptide able to promote an innate but not an adaptive response in celiac disease. Journal of peptide science : an official publication of the European Peptide Society 18 30912242
1989 Efficient expression of genetically engineered hepatitis B virus surface antigen P31 proteins in yeast. Gene 18 2673925
1985 P31, a mammalian housekeeping protein encoded by a multigene family containing a high proportion of pseudogenes. Biochimica et biophysica acta 17 2996604
1982 A novel monocytoid cultured cell line, P31/Fujioka, derived from acute monoblastic leukemia. Gan 17 6962783
2021 Novel t(1;8)(p31.3;q21.3) NFIA-RUNX1T1 Translocation in an Infant Erythroblastic Sarcoma. American journal of clinical pathology 16 33313700
2019 Role of Polo-like kinase 1 in the regulation of the action of p31comet in the disassembly of mitotic checkpoint complexes. Proceedings of the National Academy of Sciences of the United States of America 16 31118282
1999 Partial mapping and sequencing of a fish iridovirus genome reveals genes homologous to the frog virus 3 p31, p40 and human eIF2alpha. Virus research 16 10509716
1985 Expression of hepatitis B virus surface antigen P31 gene in Escherichia coli. Gene 15 3005125
1999 Optimized cardiac graft preservation: a comparative experimental study using P-31 magnetic resonance spectroscopy and biochemical analyses. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 14 10395355
2013 p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs. SpringerPlus 13 24255856
2007 IgE anti-Borrelia burgdorferi components (p18, p31, p34, p41, p45, p60) and increased blood CD8+CD60+ T cells in children with Lyme disease. Scandinavian journal of immunology 13 17386029
2000 BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like. International journal of cancer 13 11072235
1994 Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. Genomics 13 7835889
1983 [Is the HLA-DR associated glycoprotein p31 a ubiquitous molecule?]. Hoppe-Seyler's Zeitschrift fur physiologische Chemie 13 6607872
2021 Mitochondrial DNA copy number and heteroplasmy load correlate with skeletal muscle oxidative capacity by P31 MR spectroscopy. Aging cell 12 34612579
2013 Coordinated regulation of p31(Comet) and Mad2 expression is required for cellular proliferation. Cell cycle (Georgetown, Tex.) 12 24131926
2007 Complex balanced translocation t(1;5;7)(p32.1;q14.3;p21.3) and two microdeletions del(1)(p31.1p31.1) and del(7)(p14.1p14.1) in a patient with features of Greig cephalopolysyndactyly and mental retardation. American journal of medical genetics. Part A 12 17937435
1991 Abnormal testicular function: potential of P-31 MR spectroscopy in diagnosis. Radiology 12 2014287
2023 Biallelic variants in MAD2L1BP (p31) cause female infertility characterized by oocyte maturation arrest. eLife 11 37334967
2017 Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells. Oncotarget 11 29212260
2016 Draft Genome Sequence of Phosphate-Solubilizing Bacterium Paraburkholderia tropica Strain P-31 Isolated from Pomegranate (Punica granatum) Rhizosphere. Genome announcements 11 27540068
1998 Monoclonal antibody P-31 recognizes a novel intermediate filament-associated protein (p250) in rat podocytes. The American journal of physiology 11 9612338
2018 MAD2-p31comet axis deficiency reduces cell proliferation, migration and sensitivity of microtubule-interfering agents in glioma. Biochemical and biophysical research communications 10 29408509
2016 CANPMR syndrome and chromosome 1p32-p31 deletion syndrome coexist in two related individuals affected by simultaneous haplo-insufficiency of CAMTA1 and NIFA genes. Molecular cytogenetics 9 26848311
1995 Confirmed assignment of a novel human tyrosine kinase gene (JAK1A) to 1p32.3-->p31.3 by nonisotopic in situ hybridization. Cytogenetics and cell genetics 8 7698020
1991 Immunohistochemical assessment of ER-P31, a mouse anti-oestrogen receptor protein monoclonal antibody in human breast cancers: comparison with ER-ICA (Abbott) and radioligand assays. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 8 1705046
2015 Phosphorylation of Xenopus p31(comet) potentiates mitotic checkpoint exit. Cell cycle (Georgetown, Tex.) 7 25892037
2000 Response in shape and size of individual p31 cancer cells to cisplatin and ouabain: a computerized image analysis of cell halo characteristics during continuous perfusion. Cytometry 7 10878562
1997 Fluxes through cytosolic and mitochondrial creatine kinase, measured by P-31 NMR. Molecular and cellular biochemistry 7 9309663
1984 On a basic 31 kDa muscle membrane protein in cattle and pig, presumably equivalent to the class II antigen associated p31 molecule. Animal blood groups and biochemical genetics 7 6517391
2024 Identification of novel M2 macrophage-related molecule ATP6V1E1 and its biological role in hepatocellular carcinoma based on machine learning algorithms. Journal of cellular and molecular medicine 6 39294741
2021 Gamma-gliadin specific celiac disease antibodies recognize p31-43 and p57-68 alpha gliadin peptides in deamidation related manner as a result of cross-reaction. Amino acids 6 34059947
1997 Identification and preliminary characterization of p31, a new PSTAIRE-related protein in fission yeast. Yeast (Chichester, England) 6 9219337
2017 Meiotic defects and decreased expression of genes located around the chromosomal breakpoint in the testis of a patient with a novel 46,X,t(Y;1)(p11.3;p31) translocation. International journal of molecular medicine 5 28627638
1998 The influence of temperature on metabolic and cellular protection of the heart during long-term ischemia: a study using P-31 magnetic resonance spectroscopy and biochemical analyses. Cryobiology 5 9917347
1995 P-31 changes as a measure of therapy response in resistant and sensitive osteosarcomas implanted into nude mice. Magnetic resonance imaging 5 8544659
1985 Computer simulation of the P31 NMR equations governing the creatine kinase reaction. Journal of theoretical biology 4 4010311
1990 Acute monocytic leukemia with translocation t(1;11) (p31;q23): simultaneous staining of chromosomes and cell surface antigens. Haematology and blood transfusion 3 1691129
2021 The Mad2-Binding Protein p31comet as a Potential Target for Human Cancer Therapy. Current cancer drug targets 2 33511944
2025 Alterations in NFAT5 and ATP6V1E1 expression as potential diagnostic biomarkers in blood and brain for Alzheimer's disease: A study of gene overlap. Brain research 1 40187519
2025 ATP6V1E1 and NDUFB5 identified as potential biomarkers for Alzheimer's disease through integrative analysis. International journal of biological macromolecules 1 41242442
2024 Novel artemisinin derivative P31 inhibits VEGF-induced corneal neovascularization through AKT and ERK1/2 pathways. Heliyon 1 38699723
2021 Generation of induced pluripotent stem cell line (KRIBBi004-A) from adult bone marrow CD34+ cells from a patient carrying 46,XX,t(1;5)(p31.1;35.1) karyotype. Stem cell research 1 34736040
1992 [Polypeptides p14 and p31 of the African swine fever virus--early proteins located on the membrane of the infected cell]. Voprosy virusologii 1 1441444
2026 Natural genetic variation of a single amino acid in beet necrotic yellow vein virus P31 protein modulates evasion of plant ubiquitination-mediated antiviral immunity. PLoS pathogens 0 41481767
2026 Mycobacterium tuberculosis modulates phosphorylation of host ATP6V1E1 to promote intracellular survival. Nature communications 0 41651829
2025 p31Comet Splice Variants Induce Distinct Spindle Assembly Checkpoint Dynamics due to Their Unique N-Termini. International journal of molecular sciences 0 40243841
2025 The Amelioration of Methionine Restriction on the Celiac Toxic Effects of p31-43 Gliadin Peptide Is Disrupted by S-Adenosyl-Methionine. Journal of food science 0 40285463
2025 Linear ubiquitination of p31comet by HOIP couples cytokine response with mitotic regulation. Cell & bioscience 0 40462232
2025 Protective Effects Proanthocyanidin Nanoliposome Freeze-Dried Powder on Oxidative Injury in a p31-43 Induced Celiac Disease Cell Model. Food science & nutrition 0 41019173
2022 Myeloid and lymphoid neoplasm with novel complex translocation: unusual case report with T-lymphoblastic lymphoma, myeloid hyperplasia, eosinophilia, basophilia, and t(1;8;10)( (p31;q24;q11.2). Journal of hematopathology 0 38175368
2005 [A novel translocation t(1;18)(p31;p11) in a patient with myelodysplastic syndrome]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 0 15696486
1993 Acrocephalopolysyndactyly, pentalogy of Fallot, and hypoacusis in a patient with a de novo reciprocal translocation involving the short arm of chromosome 1 and the long arm of chromosome 18: 46,XX,t(1;18)(p31;q11). Journal of medical genetics 0 8320714
1988 Early stage detection of chemotherapeutic effect on 203 GL glioma in mice as studied by P-31 NMR and flow cytometry. Radiation medicine 0 3145536
1987 Interaction between human albumin polymers and the envelope polypeptide of hepatitis B virus (P31) containing the translation product of the pre-S2 region. The Japanese journal of experimental medicine 0 3669400
1985 [Study of the protective effect of phosphocreatine on the ischemic myocardium during cardioplegia using the P-31 NMR method]. Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR 0 4005052
1982 [Study of nucleotide biosynthesis by cultured Brevibacterium ammoniagenes using P31 nuclear magnetic resonance spectroscopy]. Prikladnaia biokhimiia i mikrobiologiia 0 7079251