Affinage

STX8

Syntaxin-8 · UniProt Q9UNK0

Round 2 corrected
Length
236 aa
Mass
26.9 kDa
Annotated
2026-04-28
106 papers in source corpus 9 papers cited in narrative 9 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

STX8 is an endosomal t-SNARE that assembles with syntaxin 7, vti1b, and VAMP8/endobrevin into a four-helix SNARE core complex to drive late endosome fusion and cargo delivery to lysosomes (PMID:11101518). It localizes primarily to early and late endosomes, where it mediates clathrin-independent transport from early to late endosomes, and its recycling from the prevacuolar endosome to the trans-Golgi network depends on Snx3-retromer recognition of a non-canonical IEMxxM sorting motif (PMID:10564279, PMID:33788833). The tumor suppressor Mig-6 bridges internalized EGFR to STX8-dependent late-endosomal trafficking, promoting lysosomal degradation of EGFR; loss of Mig-6 in glioblastoma sustains aberrant EGFR signaling (PMID:20351267). STX8 is also co-opted by intracellular pathogens and participates in hypoxia-driven autophagic secretion of mitochondria via extracellular vesicles in head and neck squamous cell carcinoma (PMID:41979085).

Mechanistic history

Synthesis pass · year-by-year structured walk · 7 steps
  1. 1998 Medium

    Identification of STX8 as a novel syntaxin/SNAP-25-subfamily SNARE with a predicted transmembrane anchor established it as a candidate vesicle-trafficking component, though its initial localization was ascribed to the ER.

    Evidence cDNA cloning, immunofluorescence co-localization with ER markers, sequence analysis

    PMID:9852078

    Open questions at the time
    • Initial ER localization was subsequently revised to endosomes by later studies
    • No functional data or binding partners identified
  2. 1999 High

    Re-evaluation of STX8 localization placed it predominantly on early endosomes and demonstrated its requirement for clathrin-independent transport from early to late endosomes, resolving its compartmental identity and revealing its trafficking function.

    Evidence Immunofluorescence with endosomal markers, co-immunoprecipitation of SNARE complexes, α-SNAP/NSF dissociation assay, functional endocytic trafficking assays

    PMID:10564279

    Open questions at the time
    • Identity of cognate SNARE partners not yet determined
    • Structural basis for STX8 position in the SNARE bundle unknown
  3. 2000 High

    Reconstitution of a quaternary SNARE core complex (syntaxin 7 / STX8 / vti1b / VAMP8) defined the cognate fusion machinery for late endosomes and established that STX8 occupies the SNAP-25 C-terminal helix position.

    Evidence Reciprocal co-immunoprecipitation of all four SNAREs, in vitro late endosome fusion inhibition with specific antibodies, EGF-to-lysosome degradation assay, biophysical characterization of purified complex

    PMID:11101518

    Open questions at the time
    • No high-resolution structure of the endosomal SNARE complex
    • Regulatory mechanisms controlling complex assembly/disassembly not addressed
  4. 2010 High

    Discovery that the tumor suppressor Mig-6 directly binds STX8 to route EGFR into late endosomes for degradation revealed a mechanism linking receptor tyrosine kinase downregulation to SNARE-dependent trafficking and explained how Mig-6 loss sustains oncogenic signaling in glioblastoma.

    Evidence Co-immunoprecipitation of Mig-6–STX8, EGFR degradation/trafficking assays, Mig-6 knockdown/overexpression with phenotypic rescue, in vivo glioma models

    PMID:20351267

    Open questions at the time
    • Binding interface between Mig-6 and STX8 not structurally resolved
    • Whether other RTKs are routed through the same Mig-6–STX8 axis is untested
  5. 2021 High

    Systematic mutagenesis in S. pombe identified an IEMxxM motif as the Snx3-retromer sorting signal for Stx8 recycling from prevacuolar endosome to TGN, defining a non-canonical retromer cargo recognition mechanism.

    Evidence Alanine-scanning mutagenesis of sorting motif residues, genetic deletion of retromer/sorting nexin components with trafficking readout, fluorescence microscopy

    PMID:33788833

    Open questions at the time
    • Conservation and functional necessity of the IEMxxM motif in mammalian STX8 not tested
    • Direct structural interaction between Snx3 and the sorting motif not demonstrated
  6. 2024 Medium

    Photoaffinity labeling showed that mycobacterial trehalose dimycolate binds STX8 and VTI1B, redirecting them into a non-canonical complex with VAMP2 instead of VAMP8, thereby blocking phagosome maturation — revealing a pathogen strategy to subvert endosomal SNARE specificity.

    Evidence Clickable TDM photoaffinity probe, mass spectrometry, co-immunoprecipitation of canonical vs. non-canonical SNARE complexes, phagosome maturation and intracellular bacterial replication assays (preprint)

    PMID:bio_10.1101_2024.12.16.627577

    Open questions at the time
    • Preprint not yet peer-reviewed
    • Structural basis for TDM-induced SNARE partner switching unknown
    • Whether VAMP2 engagement is sufficient or requires additional host factors is unresolved
  7. 2026 Medium

    STX8 was identified as a SNARE component of multivesicular body membranes that, together with VAMP4, mediates hypoxia-driven autophagic secretion of mitochondria via extracellular vesicles in HNSCC, linking endosomal SNARE function to tumor immune evasion.

    Evidence Multivesicular body membrane proteomics, co-IP/pulldown, functional EV secretion and macrophage polarization assays under hypoxia, knockdown experiments

    PMID:41979085

    Open questions at the time
    • Single study; independent replication needed
    • Whether STX8's role in EV-mediated mitophagy extends beyond HNSCC or hypoxic conditions is unknown
    • Mechanism by which STX8 is recruited to MVB membranes under hypoxia not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • A high-resolution structure of the endosomal SNARE complex containing STX8 is lacking, the mammalian retromer sorting motif for STX8 recycling has not been validated, and the full scope of pathogen effectors that co-opt STX8 remains undefined.
  • No atomic-resolution structure of the STX7/STX8/VTI1B/VAMP8 complex
  • Mammalian IEMxxM motif conservation and function untested
  • Breadth of pathogen exploitation of STX8-containing SNARE complexes incompletely mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 1
Localization
GO:0005768 endosome 3 GO:0031410 cytoplasmic vesicle 2 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-9612973 Autophagy 1
Partners
ERRFI1SNX3STX7VAMP8VPS35VTI1B
Complex memberships
STX7/STX8/VTI1B/VAMP8 late-endosomal SNARE complex

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 Syntaxin 8 was identified as a novel member of the syntaxin/SNAP-25 subfamily of SNAREs. It is broadly expressed and, by immunofluorescence, co-localizes with markers of the endoplasmic reticulum, suggesting a role in vesicle trafficking at that compartment. It contains a predicted C-terminal transmembrane anchor. cDNA cloning, immunofluorescence co-localization with ER markers, sequence analysis The Journal of biological chemistry Medium 9852078
1999 Human STX8 cDNA was cloned using the CFTR R-domain as bait in a yeast two-hybrid screen of a fetal lung library. STX8 encodes a 236-amino-acid protein mapping to chromosomal band 17p12. Its C-terminal half contains a coiled-coil domain conserved in the t-SNARE superfamily and a C-terminal hydrophobic transmembrane anchor, consistent with a role in vesicular trafficking and docking. Yeast two-hybrid screening, cDNA cloning, FISH chromosomal mapping, sequence/structural analysis Biochemical and biophysical research communications Medium 10198254
1999 Syntaxin 8 localizes predominantly to early endosomes and functions in clathrin-independent vesicular transport and membrane fusion events required for protein transport from early endosomes (EEs) to late endosomes (LEs). STX8-containing SNARE complexes are dissociated by α-SNAP and NSF, confirming canonical SNARE behavior. This is distinct from syntaxin 7, which localizes to vacuolar EEs and mediates plasma membrane-to-EE and homotypic endosome fusion. Immunofluorescence co-localization with endosomal markers, co-immunoprecipitation of SNARE complexes, α-SNAP/NSF dissociation assay, functional endocytic trafficking assays Molecular biology of the cell High 10564279
2000 Syntaxin 7, syntaxin 8, vti1b, and endobrevin/VAMP-8 form a cognate four-helix SNARE core complex that mediates fusion of late endosomes. Antibodies specific for each of the four proteins co-precipitate the entire complex, inhibit homotypic late endosome fusion in vitro, and retard delivery of endocytosed EGF to lysosomes. Substitution experiments and structural comparisons show that syntaxin 8 occupies the position corresponding to the C-terminal domain of SNAP-25 in the neuronal complex. Reciprocal co-immunoprecipitation of all four SNARE components, in vitro late endosome fusion inhibition assay with specific antibodies, EGF-to-lysosome trafficking assay, biophysical characterization of purified core complex, sequence/structural comparison The EMBO journal High 11101518
2010 The tumor suppressor Mig-6 binds directly to STX8 and uses this interaction to drive ligand-stimulated EGFR into late endosomes for lysosomal degradation. Loss of Mig-6 in glioblastoma sustains aberrant EGFR signaling. Mechanistically, Mig-6 acts as a molecular bridge linking internalized EGFR to STX8-dependent late endosome trafficking, thereby suppressing gliomagenesis. Co-immunoprecipitation of Mig-6 with STX8, genomic deletion analysis (focal 1p36 deletion in GBM), EGFR degradation/trafficking assays (late endosome delivery, lysosomal degradation), Mig-6 knockdown/overexpression with phenotypic rescue, in vivo glioma models Proceedings of the National Academy of Sciences of the United States of America High 20351267
2021 In Schizosaccharomyces pombe, Stx8 (Fsv1) localizes to both the trans-Golgi network (TGN) and the prevacuolar endosome (PVE). Its SNARE domain is required for vesicle fusion at the PVE, confirming conserved syntaxin-8 function. Stx8 recycling from the PVE to the TGN requires the retromer component Vps35 and sorting nexins Vps5, Vps17, and Snx3, identifying Stx8 as a Snx3-retromer cargo. Mutagenesis mapped the retromer sorting signal to an IEMeaM sequence (residues 133I, 134E, 135M, 138M essential) in an unstructured region distal from the transmembrane helix, a motif distinct from canonical aromatic-residue-containing retromer signals. Fluorescence microscopy (localization), truncation and alanine-scanning mutagenesis of sorting signal, genetic deletion of retromer/sorting nexin components with trafficking phenotype readout, salt sensitivity assay in stx8Δ cells PLoS genetics High 33788833
2024 A clickable photoaffinity probe mimicking trehalose dimycolate (TDM) from Mycobacterium tuberculosis binds the host SNARE proteins VTI1B, STX8, and VAMP2 in macrophages. Normally, VTI1B and STX8 promote endosome fusion by forming a complex with VAMP8. However, in the presence of M. tuberculosis or TDM, VTI1B and STX8 engage non-canonically with VAMP2 instead, reducing VAMP8 binding and thereby inhibiting phagosome maturation and promoting intracellular M. tuberculosis replication. Photoaffinity labeling with clickable TDM probe, mass spectrometry identification of bound SNARE proteins, co-immunoprecipitation of SNARE complexes (canonical vs. non-canonical), phagosome maturation assay, intracellular bacterial replication assay bioRxivpreprint Medium bio_10.1101_2024.12.16.627577
2024 Salmonella effector protein SipA interacts with syntaxin 8 (STX8) to help maintain the Salmonella-containing vacuole (SCV) and prevent lysosomal fusion, supporting intracellular bacterial survival. BioID proximity labeling screen, referenced interaction of SipA with STX8 based on SPI effector interactome data bioRxivpreprint Low bio_10.1101_2024.12.12.628128
2026 Under hypoxic conditions in head and neck squamous cell carcinoma (HNSCC), STX8 together with VAMP4 mediates autophagic secretion of mitochondria via extracellular vesicles (EVs). This mitophagy-dependent EV secretion promotes tumor-associated macrophage polarization toward an immunosuppressive phenotype, reshaping the tumor immune microenvironment. STX8 was identified as a key SNARE component of multivesicular body membrane-mediated secretion in this context. Multivesicular body membrane proteomics, molecular interaction validation (co-IP/pulldown implied), functional assays of EV secretion and macrophage polarization under hypoxia, knockdown experiments Journal of extracellular vesicles Medium 41979085

Source papers

Stage 0 corpus · 106 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Towards a proteome-scale map of the human protein-protein interaction network. Nature 2090 16189514
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2010 Network organization of the human autophagy system. Nature 1286 20562859
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2000 A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. The EMBO journal 229 11101518
2018 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nature communications 201 29568061
2011 Next-generation sequencing to generate interactome datasets. Nature methods 200 21516116
1998 Three novel proteins of the syntaxin/SNAP-25 family. The Journal of biological chemistry 165 9852078
2000 SNAREs contribute to the specificity of membrane fusion. Neuron 161 10839363
2019 A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nature immunology 159 30833792
1983 The carB gene of Escherichia coli: a duplicated gene coding for the large subunit of carbamoyl-phosphate synthetase. Proceedings of the National Academy of Sciences of the United States of America 155 6308632
2005 Scanning the human proteome for calmodulin-binding proteins. Proceedings of the National Academy of Sciences of the United States of America 139 15840729
2019 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Nature cell biology 137 31871319
1999 Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. Molecular biology of the cell 121 10564279
2009 Genetic risk profiling and prediction of disease course in Crohn's disease patients. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 117 19422935
2007 Toward a confocal subcellular atlas of the human proteome. Molecular & cellular proteomics : MCP 114 18029348
2021 Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 113 34349018
2009 Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. The American journal of gastroenterology 113 19174780
2010 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Molecular medicine (Cambridge, Mass.) 108 20379614
2010 Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America 99 20351267
2016 Vina-Carb: Improving Glycosidic Angles during Carbohydrate Docking. Journal of chemical theory and computation 90 26744922
1991 Construction by polymerase chain reaction and use of intragenic DNA probes for three main types of transferable beta-lactamases (TEM, SHV, CARB) [corrected]. FEMS microbiology letters 86 1936934
2012 Relatively high-protein or 'low-carb' energy-restricted diets for body weight loss and body weight maintenance? Physiology & behavior 78 22935440
2015 CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus. Antimicrobial agents and chemotherapy 55 25801555
2002 A carotenoid biosynthesis gene cluster in Fusarium fujikuroi: the genes carB and carRA. Molecular genetics and genomics : MGG 53 12172798
2003 Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis. The Journal of biological chemistry 40 14625287
2009 Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. Antimicrobial agents and chemotherapy 39 19380596
2004 CARB-9, a carbenicillinase encoded in the VCR region of Vibrio cholerae non-O1, non-O139 belongs to a family of cassette-encoded beta-lactamases. Antimicrobial agents and chemotherapy 39 15388476
2014 Evaluation of five chromogenic agar media and the Rosco Rapid Carb screen kit for detection and confirmation of carbapenemase production in Gram-negative bacilli. Journal of clinical microbiology 35 25355764
1990 Methylation of 23S ribosomal RNA due to carB, an antibiotic-resistance determinant from the carbomycin producer, Streptomyces thermotolerans. European journal of biochemistry 35 1691981
2002 New carbenicillin-hydrolyzing beta-lactamase (CARB-7) from Vibrio cholerae non-O1, non-O139 strains encoded by the VCR region of the V. cholerae genome. Antimicrobial agents and chemotherapy 34 12069969
2000 Identification of CIP-1-associated regulator of cyclin B (CARB), a novel p21-binding protein acting in the G2 phase of the cell cycle. The Journal of biological chemistry 29 10781590
1998 The carB gene encoding the large subunit of carbamoylphosphate synthetase from Lactococcus lactis is transcribed monocistronically. Journal of bacteriology 27 9721272
2005 Analysis of mating-dependent transcription of Blakeslea trispora carotenoid biosynthesis genes carB and carRA by quantitative real-time PCR. Applied microbiology and biotechnology 25 15744487
2004 Operator design and mechanism for CarA repressor-mediated down-regulation of the photoinducible carB operon in Myxococcus xanthus. The Journal of biological chemistry 24 15123730
2000 Nucleotide sequence of the bla(RTG-2) (CARB-5) gene and phylogeny of a new group of carbenicillinases. Antimicrobial agents and chemotherapy 24 10722515
1999 Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8). Biochemical and biophysical research communications 23 10198254
1999 Characterization and nucleotide sequence of CARB-6, a new carbenicillin-hydrolyzing beta-lactamase from Vibrio cholerae. Antimicrobial agents and chemotherapy 23 9925522
2006 Low-carb diets, fasting and euphoria: Is there a link between ketosis and gamma-hydroxybutyrate (GHB)? Medical hypotheses 22 17011713
2014 A case of IMP-4-, OXA-421-, OXA-96-, and CARB-2-producing Acinetobacter pittii sequence type 119 in Australia. Journal of clinical microbiology 21 25428154
1998 Structure of CARB-4 and AER-1 carbenicillin-hydrolyzing beta-lactamases. Antimicrobial agents and chemotherapy 21 9687391
2015 Molecular study on the carAB operon reveals that carB gene is required for swimming and biofilm formation in Xanthomonas citri subsp. citri. BMC microbiology 20 26494007
2014 Thio-sugar motif of functional CARB-pharmacophore for antineoplastic activity. Part 2. Bioorganic & medicinal chemistry letters 19 25466184
1989 Novel carbenicillin-hydrolyzing beta-lactamase (CARB-5) from Acinetobacter calcoaceticus var. anitratus. FEMS microbiology letters 19 2786828
2017 MDD-carb: a combinatorial model for the identification of protein carbonylation sites with substrate motifs. BMC systems biology 17 29322938
2023 Effects of the low-carb organic Mediterranean diet on testosterone levels and sperm DNA fragmentation. Current research in food science 16 38045510
2021 Rapid and Visual Detection of Vibrio parahaemolyticus in Aquatic Foods Using blaCARB-17 Gene-Based Loop-Mediated Isothermal Amplification with Lateral Flow Dipstick (LAMP-LFD). Journal of microbiology and biotechnology 15 34489378
2014 A potential CARB-pharmacophore for antineoplastic activity: part 1. Bioorganic & medicinal chemistry letters 15 24602905
2021 Retrospective cohort study of changes in estimated glomerular filtration rate for patients prescribed a low carb diet. Current opinion in endocrinology, diabetes, and obesity 12 34392262
2014 Carb-3 is the superior anti-CD15 monoclonal antibody for immunohistochemistry. Applied immunohistochemistry & molecular morphology : AIMM 10 23846425
2023 A low-carb diet increases fecal short-chain fatty acids in feces of obese women following a weight-loss program: randomized feeding trial. Scientific reports 9 37875472
2020 Carb-Loading: Freeze-Induced Activation of the Glucose-Responsive ChREBP Transcriptional Network in Wood Frogs. Physiological and biochemical zoology : PBZ 9 31742477
2020 Effects of a Low Carb Diet and Whey Proteins on Anthropometric, Hematochemical, and Cardiovascular Parameters in Subjects with Obesity. Endocrine, metabolic & immune disorders drug targets 9 32520693
2017 A novel GoldNano Carb test for rapid phenotypic detection of carbapenemases, particularly OXA type, in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp. The Journal of antimicrobial chemotherapy 9 28535303
1999 Heterologous expression of the Phycomyces blakesleeanus phytoene dehydrogenase gene (carB) in Mucor circinelloides. Current microbiology 9 10489434
2021 Changes in Quantity and Sources of Dietary Fiber from Adopting Healthy Low-Fat vs. Healthy Low-Carb Weight Loss Diets: Secondary Analysis of DIETFITS Weight Loss Diet Study. Nutrients 8 34684626
2020 Structural analysis of the CARB β-lactamase from Vibrio parahaemolyticus facilitates application of the β-lactam/β-lactamase inhibitor therapy. Biochimie 8 32179166
2008 Campylobacter jejuni host tissue tropism: a consequence of its low-carb lifestyle? Cell host & microbe 8 18996338
1997 Identification of greA encoding a transcriptional elongation factor as a member of the carA-orf-carB-greA operon in Pseudomonas aeruginosa PAO1. Journal of bacteriology 8 9139926
2023 Rapid generation of CD19 CAR-T cells by minicircle DNA enables anti-tumor activity and prevents fatal CAR-B leukemia. Cancer letters 7 37354981
2023 Centrally acting ACE inhibitor (cACEi) and angiotensin receptor blocker (cARB) use and cognitive dysfunction in patients with SLE. Lupus science & medicine 6 37429671
2022 SPINA Carb: a simple mathematical model supporting fast in-vivo estimation of insulin sensitivity and beta cell function. Scientific reports 6 36271244
2013 Specific discrimination of three pathogenic Salmonella enterica subsp. enterica serotypes by carB-based oligonucleotide microarray. Applied and environmental microbiology 6 24185846
2010 Protein-DNA interactions in the promoter region of the Phycomyces carB and carRA genes correlate with the kinetics of their mRNA accumulation in response to light. Fungal genetics and biology : FG & B 6 20580936
1995 Induction of protein oxidation in human low density lipoprotein by the photosensitive organic hydroperoxide, N,N'-bis(2-hydroxyperoxy-2-methoxyethyl)-1,4,5,8-naphthalene-tetra-carb oxylic- diimide. Biochemical and biophysical research communications 6 7818513
2022 Nutritional Quality of Gluten-Free Bakery Products Labeled Ketogenic and/or Low-Carb Sold in the Global Market. Foods (Basel, Switzerland) 5 36553837
2015 Diversity of Rhodopirellula and related planctomycetes in a North Sea coastal sediment employing carB as molecular marker. FEMS microbiology letters 5 26253575
2019 A highly resistant structure between the cuticle and the cortex of human hair. II. CARB, a penetration barrier. International journal of cosmetic science 4 30549286
2008 Fly-let biology and the high protein/low carb diet. Cell metabolism 4 18396131
2021 Analysis of the SNARE Stx8 recycling reveals that the retromer-sorting motif has undergone evolutionary divergence. PLoS genetics 3 33788833
2021 The effect of high-fat versus high-carb diet on body composition in strength-trained males. Food science & nutrition 3 34026070
2021 Custard apple puree, fructooligosaccharide and soy protein hydrolysate as alternative ingredients in low carb pound cake. Journal of food science and technology 3 34366480
2021 Low-carb Diet in Hospitalized Late Pubertal Type 1 Diabetic Girls: A Short-Term CGM Study. Indian journal of endocrinology and metabolism 3 34386391
2018 [Analyses on distribution and structure of blaCARB-2 in Klebsiella pneumoniae]. Yi chuan = Hereditas 3 30021722
2021 A new tetra-kis-substituted pyrazine carb-oxy-lic acid, 3,3',3'',3'''-{[pyrazine-2,3,5,6-tetra-yltetra-kis(methyl-ene)]tetra-kis-(sulfanedi-yl)}tetra-propionic acid: crystal structures of two triclinic polymorphs and of two potassium-organic frameworks. Acta crystallographica. Section E, Crystallographic communications 2 34026250
2012 Glycosyltransferases: carb loading strategy is spot on. Nature chemical biology 2 22907089
2010 4-(4-Pyrid-yl)pyridinium 3-amino-5-carb-oxy-2,4,6-triiodo-benzoate-5-amino-2,4,6-triiodo-isophthalic acid (1/1). Acta crystallographica. Section E, Structure reports online 2 21589461
2002 Should you recommend a low-carb, high-protein diet? The Nurse practitioner 2 11984418
2025 Crystal structure, Hirshfeld surface analysis, DFT and mol-ecular docking studies of 4'-(benz-yloxy)-[1,1'-biphen-yl]-3-carb-oxy-lic acid. Acta crystallographica. Section E, Crystallographic communications 1 40071035
2025 The Role of Diet and Hormones on Taste: Low Carb Compared With Low Fat Study Findings. Current developments in nutrition 1 40606290
2024 Synthesis of 2-Amino-N'-aroyl(het)arylhydrazides, DNA Photocleavage, Molecular Docking and Cytotoxicity Studies against Melanoma CarB Cell Lines. Molecules (Basel, Switzerland) 1 38338390
2024 Short-term high-fat and high-carb diet effects on glucose metabolism and hedonic regulation in young healthy men. Frontiers in nutrition 1 39534438
2021 A highly resistant structure between the cuticle and the cortex of human hair III: Characterzation of the structure CARB. International journal of cosmetic science 1 33527469
2021 The carB Gene of Escherichia coli BL21(DE3) is Associated with Nematicidal Activity against the Root-Knot Nematode Meloidogyne javanica. Pathogens (Basel, Switzerland) 1 33670696
2018 Carb loading takes proteins on a ride. The Journal of biological chemistry 1 29626108
2014 Crystal structure of 9-(4-bromo-but-yl)-9H-fluorene-9-carb-oxy-lic acid. Acta crystallographica. Section E, Structure reports online 1 25484705
2012 catena-Poly[[[bis-[μ-3-(4-carb-oxy-phen-oxy)propionato]-κO,O:O;κO:O,O-bis-[aqua-(N,N-dimethyl-formamide-κO)cadmium]]-μ-4,4'-bipyridine-κN:N'] dinitrate]. Acta crystallographica. Section E, Structure reports online 1 22346877
2026 VAMP4/STX8 Mediate the Autophagic Secretion of Mitochondria and Promote TAMs Polarization in HNSCC. Journal of extracellular vesicles 0 41979085
2025 Associations of low-carb diets with glycaemic control and diabetic complications among adult Ghanaians: the RODAM study. European journal of nutrition 0 40481960
2025 Distribution and Evolutionary Trajectories of β-Lactamases in Vibrio: Genomic Insights from Carbenicillin-Hydrolyzing Class A β-Lactamases (CARB) in the Harveyi and Cholerae Clades. Genome biology and evolution 0 40556499
2025 Modulation of Gut Bacterial and Fungal Microbiota in Fibromyalgia Patients Following a Carb-Free Oloproteic Diet: Evidence for Candida Suppression and Symptom Improvement. Microorganisms 0 41011401
2025 Deciphering the Role of VIM, STX8, and MIF in Pneumoconiosis Susceptibility: A Mendelian Randomization Analysis of the Lung-Gut Axis and Multi-Omics Insights from European and East Asian Populations. Biomedical and environmental sciences : BES 0 41196107
2021 Current Evidence Regarding Low-carb Diets for The Metabolic Control of Type-2 Diabetes. Current diabetes reviews 0 33231159
2020 [The content of essential and toxic microelements in the organs of mice of various lines receiving a high-carb high-fat diet and supplemented with quercetin]. Voprosy pitaniia 0 32459903
2012 The attachment disorders of muscle: failure to carb-load. The Journal of clinical investigation 0 22922262