Affinage

CLTA

Clathrin light chain A · UniProt P09496

Round 2 corrected
Length
248 aa
Mass
27.1 kDa
Annotated
2026-04-28
130 papers in source corpus 4 papers cited in narrative 4 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CLTA encodes clathrin light chain A (LCa), one of two light chain classes that associate with clathrin heavy chains via a central alpha-helical coiled-coil domain to form the clathrin triskelion, the structural unit of clathrin-coated vesicles (PMID:3563513). LCa binds the uncoating ATPase hsc70 through a proline/glycine-rich region (residues 47–71) and stimulates its ATPase activity; this region undergoes reversible conformational changes in response to ionic strength and calcium, enabling LCa to regulate clathrin-coated vesicle disassembly (PMID:1975516). The CLTA gene produces tissue-specific isoforms through alternative splicing of two neuron-specific exons (PMID:7713494).

Mechanistic history

Synthesis pass · year-by-year structured walk · 4 steps
  1. 1987 High

    Cloning of LCa and LCb cDNAs established that the two clathrin light chain classes share a conserved central coiled-coil domain predicted to bind heavy chains, resolving the structural basis of their association with the triskelion and revealing alternative-splicing-based polymorphism within each class.

    Evidence cDNA cloning and sequence analysis from rat brain and liver

    PMID:3563513

    Open questions at the time
    • No direct binding data confirming the coiled-coil domain as the heavy chain interaction site
    • Functional distinction between LCa and LCb isoforms not yet determined
  2. 1990 High

    Biochemical reconstitution demonstrated that LCa directly binds the uncoating ATPase hsc70, stimulates its ATP hydrolysis, and inhibits clathrin coat disassembly, with the binding site mapping to a conformationally labile Pro/Gly-rich segment (residues 47–71) whose conformation is regulated by calcium and ionic strength — establishing a mechanistic link between light chain conformation and coated vesicle uncoating.

    Evidence Purified protein binding assays, ATPase stimulation with synthetic peptides, in vitro uncoating inhibition, and ionic strength/calcium perturbation

    PMID:1975516

    Open questions at the time
    • In vivo validation of calcium/ionic-strength regulation of uncoating is lacking
    • Whether conformational regulation occurs in the context of the intact triskelion is not shown
    • Structural basis of the conformational switch at residues 47–71 not resolved
  3. 1994 High

    Genomic mapping placed human CLTA at chromosome 12q23–q24 and revealed that the neuron-specific LCa isoform arises from two discrete alternatively spliced exons, establishing the gene-structure basis for tissue-specific clathrin light chain diversity.

    Evidence Chromosomal mapping by Southern blot of flow-sorted chromosomes and somatic cell hybrids; partial genomic clone characterization

    PMID:7713494

    Open questions at the time
    • Functional significance of the neuron-specific exon insertions not tested
    • Regulatory elements controlling neuron-specific splicing not identified
  4. 2018 Medium

    Endogenous CLTA tagging via CRISPR/Cas9 in human iPSCs enabled live-cell visualization of clathrin light chain A trafficking, providing a tool to study clathrin-mediated endocytosis at physiological expression levels in diverse differentiated cell types.

    Evidence CRISPR/Cas9 knock-in of fluorescent tag at endogenous CLTA locus in iPSCs; live-cell imaging

    PMID:30340091

    Open questions at the time
    • Single lab and cell system; not independently replicated
    • No mechanistic insight beyond tool validation reported

Open questions

Synthesis pass · forward-looking unresolved questions
  • The in vivo regulatory logic by which LCa conformational changes tune coated vesicle uncoating kinetics, the distinct functional roles of LCa versus LCb, and the physiological consequences of neuron-specific LCa isoforms remain unresolved.
  • No in vivo structure–function analysis of the LCa conformational switch
  • No genetic loss-of-function studies defining non-redundant roles of LCa versus LCb
  • Function of neuron-specific splice variants untested in neuronal systems

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 1 GO:0098772 molecular function regulator activity 1
Localization
GO:0031410 cytoplasmic vesicle 2 GO:0005829 cytosol 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 3
Partners
CLTBCLTCHSPA8
Complex memberships
Clathrin triskelion

Evidence

Reading pass · 4 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1987 Clathrin light chains fall into two major classes, LCa (encoded by CLTA) and LCb. Sequence analysis of rat brain and liver cDNA clones revealed that both light chain classes share a central set of ten heptad elements characteristic of alpha-helical coiled coils, proposed to mediate binding to clathrin heavy chains, with amino- and carboxyl-terminal segments mediating interactions with other proteins. Several members of each class with deletions of varying length aligned at the same position were identified, indicating polymorphism within each class. cDNA cloning and sequence analysis of rat brain and liver LCA and LCB clones; structural inference from amino acid sequences Science High 3563513
1990 Clathrin light chain LCa binds the uncoating ATPase hsc70 and stimulates its ATP hydrolysis more effectively than LCb. The hsc70 binding site maps to the proline- and glycine-rich region (residues 47–71) of LCa. Unlike LCb, this region of LCa undergoes reversible conformational changes in response to changes in ionic strength or calcium ion concentration, and LCa inhibits clathrin uncoating by hsc70 more potently than LCb. These results suggest that LCa conformation regulates coated vesicle uncoating. Purified light chain binding assays with hsc70; ATPase stimulation assays with synthetic peptides; in vitro uncoating inhibition assays; ionic strength/calcium perturbation experiments Cell High 1975516
1994 The human CLTA gene encoding the LCa clathrin light chain maps to chromosome 12q23–q24. Partial genomic clone analysis revealed that the neuron-specific insertion of LCa is encoded by two discrete exons, demonstrating that clathrin light chains undergo alternative mRNA splicing to generate tissue-specific (neuronal) protein isoforms. The first of the two neuron-specific LCa exons is homologous to the corresponding LCb exon. Chromosomal mapping by Southern blot analysis of flow-sorted chromosomes and somatic cell hybrids; isolation and characterization of partial genomic clones; exon structure analysis Genomics High 7713494
2018 CRISPR/Cas9 genomic editing was used to fluorescently tag the C-terminus of endogenous CLTA in human iPSCs, generating a reporter line to monitor clathrin light chain A trafficking in living cells. Successfully edited cells remained karyotypically normal and maintained differentiation potential, enabling imaging of endogenous clathrin-dependent endocytosis in diverse cell types derived from iPSCs. CRISPR/Cas9 knock-in tagging of endogenous CLTA locus; fluorescence-activated cell sorting; karyotyping; live-cell imaging Stem cell research Medium 30340091

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2010 Network organization of the human autophagy system. Nature 1286 20562859
2009 Defining the human deubiquitinating enzyme interaction landscape. Cell 1282 19615732
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2008 Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 787 18854154
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2006 Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell 517 17110338
1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene 492 8125298
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2000 Three ways to make a vesicle. Nature reviews. Molecular cell biology 410 11252894
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2000 Secretory protein trafficking and organelle dynamics in living cells. Annual review of cell and developmental biology 380 11031247
2007 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America 360 17620599
1990 Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR. The EMBO journal 355 1695146
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2017 An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell 328 28388416
2010 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell 318 21145461
2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nature biotechnology 266 15146197
2011 A directed protein interaction network for investigating intracellular signal transduction. Science signaling 258 21900206
2017 Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification. Nature communications 221 28524877
2016 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nature communications 211 27173435
2011 Toward an understanding of the protein interaction network of the human liver. Molecular systems biology 207 21988832
2009 Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Science signaling 207 19738201
2018 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nature communications 201 29568061
2020 Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Nature cell biology 194 32203420
2005 Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA). Molecular vision 189 15765048
2011 Protein interactome reveals converging molecular pathways among autism disorders. Science translational medicine 180 21653829
2002 Accessory protein recruitment motifs in clathrin-mediated endocytosis. Structure (London, England : 1993) 165 12057195
2015 CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. Developmental cell 164 25898166
2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. American journal of human genetics 164 19913121
1990 Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis. Cell 142 1975516
1989 Leukocyte cell surface enzymology: CD45 (LCA, T200) is a protein tyrosine phosphatase. Immunology today 122 2553046
2016 In vitro and in vivo rescue of aberrant splicing in CEP290-associated LCA by antisense oligonucleotide delivery. Human molecular genetics 118 27106101
2010 Genetic screening of LCA in Belgium: predominance of CEP290 and identification of potential modifier alleles in AHI1 of CEP290-related phenotypes. Human mutation 116 20683928
1987 Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs. Science (New York, N.Y.) 88 3563513
1987 A monoclonal antibody to the p220 component of sheep LCA identifies B cells and a unique lymphocyte subset. Cellular immunology 71 2445494
2005 Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition. Proceedings of the National Academy of Sciences of the United States of America 65 16006509
2008 Mutation survey of known LCA genes and loci in the Saudi Arabian population. Investigative ophthalmology & visual science 61 18936139
2020 Retinal Organoids derived from hiPSCs of an AIPL1-LCA Patient Maintain Cytoarchitecture despite Reduced levels of Mutant AIPL1. Scientific reports 46 32214115
1996 Evidence of genetic heterogeneity of Leber's congenital amaurosis (LCA) and mapping of LCA1 to chromosome 17p13. Human genetics 46 8641699
2001 Complete abolition of the retinal-specific guanylyl cyclase (retGC-1) catalytic ability consistently leads to leber congenital amaurosis (LCA). Investigative ophthalmology & visual science 43 11328726
2024 Gut microbiota-derived LCA mediates the protective effect of PEDV infection in piglets. Microbiome 40 38317217
2015 Tanshinone IIA exerts protective effects in a LCA-induced cholestatic liver model associated with participation of pregnane X receptor. Journal of ethnopharmacology 40 25660334
1992 Purification and characterization of the catalytic domains of the human receptor-linked protein tyrosine phosphatases HPTP beta, leukocyte common antigen (LCA), and leukocyte common antigen-related molecule (LAR). The Journal of biological chemistry 39 1318316
2014 Pseudo-fovea formation after gene therapy for RPE65-LCA. Investigative ophthalmology & visual science 34 25537204
2013 Mutational screening of LCA genes emphasizing RPE65 in South Indian cohort of patients. PloS one 34 24066033
2016 How Well Does LCA Model Land Use Impacts on Biodiversity?--A Comparison with Approaches from Ecology and Conservation. Environmental science & technology 30 26830787
2021 Bile acids LCA and CDCA inhibited porcine deltacoronavirus replication in vitro. Veterinary microbiology 28 33933854
2010 Activation of retinal guanylyl cyclase RetGC1 by GCAP1: stoichiometry of binding and effect of new LCA-related mutations. Biochemistry 28 20050595
2020 Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion. Molecular therapy. Nucleic acids 27 32402942
2006 Cortical visual function in the rd12 mouse model of Leber Congenital Amarousis (LCA) after gene replacement therapy to restore retinal function. Vision research 27 16814838
2017 The importance of genetic testing as demonstrated by two cases of CACNA1F-associated retinal generation misdiagnosed as LCA. Molecular vision 26 29062221
2016 LCA*: an entropy-based measure for taxonomic assignment within assembled metagenomes. Bioinformatics (Oxford, England) 24 27515739
2022 Protein quality as a complementary functional unit in life cycle assessment (LCA). The international journal of life cycle assessment 23 36685326
2019 From Laboratory to Industrial Scale: A Prospective LCA for Electrochemical Reduction of CO2 to Formic Acid. Environmental science & technology 23 31603653
1990 Distribution of LCA protein subspecies and the cellular adhesion molecules LFA-1, ICAM-1 and p150,95 within human foetal thymus. Immunology 23 1973681
1995 Expression of the leucocyte common antigen (LCA, CD45) isoforms RA and RO in acute haematological malignancies: possible relevance in the definition of new overlap points between normal and leukaemic haemopoiesis. British journal of haematology 21 8547136
1987 Monoclonal antibodies to RT7 and LCA antigens in the rat: cell distribution and segregation analysis. Hybridoma 21 2960606
2011 Mapping of dihydropyridine binding residues in a less sensitive invertebrate L-type calcium channel (LCa v 1). Channels (Austin, Tex.) 20 21487241
2007 Mutations in LCA5 are an uncommon cause of Leber congenital amaurosis (LCA) type II. Human mutation 19 18000884
2013 A comparative LCA of rice straw utilization for fuels and fertilizer in Thailand. Bioresource technology 18 24076147
2007 Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis. Toxicological sciences : an official journal of the Society of Toxicology 18 18032408
2005 A novel mutation in the GUCY2D gene responsible for an early onset severe RP different from the usual GUCY2D-LCA phenotype. Human mutation 18 15643614
1989 The extra segments of sequence in rat leucocyte common antigen (L-CA) are derived by alternative splicing of only three exons and show extensive O-linked glycosylation. Immunogenetics 18 2523868
2021 CLTA-4 Expression is Associated with the Maintenance of Chronic Inflammation in Endometriosis and Infertility. Cells 17 33668701
2019 A Prospective Life Cycle Assessment (LCA) of Monomer Synthesis: Comparison of Biocatalytic and Oxidative Chemistry. ChemSusChem 17 30681769
2007 [Genetic and clinical heterogeneity in LCA patients. The end of uniformity]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 17 17525851
1987 Human neoplastic cell line distribution, immunoprecipitation and immunohistopathological study of a gp200 cell surface glycoprotein (LCA) detected by a monoclonal antibody elicited with an ALL cell line. Neoplasma 17 2963236
2020 Targeted bile acids and gut microbiome profiles reveal the hepato-protective effect of WZ tablet (Schisandra sphenanthera extract) against LCA-induced cholestasis. Chinese journal of natural medicines 15 32245591
2023 Durable vision improvement after a single intravitreal treatment with antisense oligonucleotide in CEP290-LCA: Replication in two eyes. American journal of ophthalmology case reports 14 37388818
2020 Novel gene variants in Polish patients with Leber congenital amaurosis (LCA). Orphanet journal of rare diseases 14 33308271
2011 A limited LCA of bio-adipic acid: manufacturing the nylon-6,6 precursor adipic acid using the benzoic acid degradation pathway from different feedstocks. Biotechnology and bioengineering 14 21328320
2017 Impact of LCA-Associated E14L LRAT Mutation on Protein Stability and Retinoid Homeostasis. Biochemistry 12 28758396
2009 Using the NAFX to measure the effectiveness over time of gene therapy in canine LCA. Investigative ophthalmology & visual science 12 19458334
1994 Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB). Genomics 12 7713494
2016 Assessing the environmental impacts of freshwater thermal pollution from global power generation in LCA. The Science of the total environment 11 28024751
2002 Alcoholic cardiomyopathy versus chronic myocarditis--immunohistological investigations with LCA, CD3, CD68 and tenascin. Forensic science international 11 11955834
2023 Genetic and Clinical Profile of Retinopathies Due to Disease-Causing Variants in Leber Congenital Amaurosis (LCA)-Associated Genes in a Large German Cohort. International journal of molecular sciences 10 37240262
2020 A natural compound (LCA) isolated from Litsea cubeba inhibits RANKL-induced osteoclast differentiation by suppressing Akt and MAPK pathways in mouse bone marrow macrophages. Journal of ethnopharmacology 10 32298753
2020 Identification of LCA-binding Glycans as a Novel Biomarker for Esophageal Cancer Metastasis using a Lectin Array-based Strategy. Journal of Cancer 10 32626520
2005 Littoral cell angioma (LCA) associated with liver cirrhosis. Yonsei medical journal 10 15744827
2022 GOntoSim: a semantic similarity measure based on LCA and common descendants. Scientific reports 9 35264663
2023 Combining LCA-MFA models to identify China's plastic value chain environmental impact mitigation pathways. iScience 8 37694146
2019 MicroRNA-424-5p inhibits the development of non-small cell LCa by binding to ITGB1. European review for medical and pharmacological sciences 7 31696479
1988 Regional localization of the LCA oncogene to human chromosome region 2q14----q21. Cytogenetics and cell genetics 7 2846240
2005 Exclusion of LCA5 locus in a consanguineous Turkish family with macular coloboma-type LCA. Eye (London, England) 6 16082399
1988 Immunocytometric characteristics of a monoclonal antibody (Bra55) recognizing the leukocyte common antigen (LCA). Neoplasma 6 2975358
2024 Total synthesis and structural modification of the dibenzylbutane lignan LCA as a potent anti-inflammatory agent against LPS-induced acute lung injury. European journal of medicinal chemistry 5 38402749
2024 A comparative review on Ayam Cemani chicken - A comparison with the most common chicken species in terms of nutritional values, LCA, price and consumer acceptance. Tropical animal health and production 5 38733430
2023 Waste-to-energy and waste-to-hydrogen with CCS: Methodological assessment of pathways to carbon-negative waste treatment from an LCA perspective. Waste management (New York, N.Y.) 5 38000195
2022 Anti-atherosclerotic effects of genistein in preventing ox-low-density lipoprotein-induced smooth muscle-derived foam cell formation via inhibiting SRC expression and L-Ca channel currents. Annals of translational medicine 5 35845495
2022 Alternative splicing in CEP290 mutant cats results in a milder phenotype than LCACEP290 patients. Veterinary ophthalmology 5 36495011
2020 Dual-color immunocytochemistry (Ki-67 with LCA) for precise grading of pancreatic neuroendocrine tumors with applicability to small biopsies and cell blocks. CytoJournal 5 32395150
2012 Profiling retinal biochemistry in the MPDZ mutant retinal dysplasia and degeneration chick: a model of human RP and LCA. Investigative ophthalmology & visual science 5 22159006
2021 Association Between Dietary Patterns and Plasma Lipid Biomarker and Female Breast Cancer Risk: Comparison of Latent Class Analysis (LCA) and Factor Analysis (FA). Frontiers in nutrition 4 34957172
2018 Natural biotic resources in LCA: Towards an impact assessment model for sustainable supply chain management. Journal of cleaner production 4 29358846
2018 Generation of a CLTA reporter human induced pluripotent stem cell line, CRMi001-A-1, using the CRISPR/Cas9 system to monitor endogenous clathrin trafficking. Stem cell research 4 30340091
2008 CLTA-4 blockade in vivo promotes the generation of short-lived effector CD8 T cells and a more persistent central memory CD4 T cell response. Journal of medical primatology 4 19187432
2007 The peptidoglycan recognition proteins LCa and LCx. Cellular and molecular life sciences : CMLS 4 17417689
1989 Responsiveness of systemic lupus erythematosus T cells to signals provided through LCA T200 (CD45) and T1 (CD5) antigens. Clinical and experimental immunology 4 12412744
2025 Identification and functional characterization of hub genes CLTA, EDIL3, HAPLN1, and HIP1 as diagnostic biomarkers and therapeutic targets in thyroid cancer and Hashimoto's thyroiditis. Clinical and experimental medicine 3 40372556
2025 Robust 16S rRNA classification based on a compressed LCA index. Genome research 3 40854687
2024 Cliffy: robust 16S rRNA classification based on a compressed LCA index. bioRxiv : the preprint server for biology 3 38854039
2023 Detecting Protein-Protein Interactions Using Bimolecular Fluorescence Complementation (BiFC) and Luciferase Complementation Assays (LCA). Methods in molecular biology (Clifton, N.J.) 3 37450143
2023 Design, Synthesis, Computational and Biological Evaluation of Novel Structure Fragments Based on Lithocholic Acid (LCA). Molecules (Basel, Switzerland) 3 37513205
2022 Association of CLTA-4 Gene Polymorphisms with Diabetes Mellitus: A Study Based on the Han Population of Northern China. Diabetes, metabolic syndrome and obesity : targets and therapy 3 36091483
2014 Cloning of cDNAs for H1F0, TOP1, CLTA and CDK1 and the effects of cryopreservation on the expression of their mRNA transcripts in yak (Bos grunniens) oocytes. Cryobiology 3 24854867
1988 The lca as an onco-fetal gene: its expression in human fetal liver. Oncogene 3 2836781
2025 LCA, a bacterial metabolite, induces ferroptosis and senescence in triple-negative breast cancer. Toxicon : official journal of the International Society on Toxinology 2 40320050
2024 Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents. RSC medicinal chemistry 2 38911165
2024 Energy from waste biomass: an LCA study on a biofuel cell at early design stage. Environmental science and pollution research international 2 38926307
2023 Cat LCA-CRX Model, Homozygous for an Antimorphic Mutation Has a Unique Phenotype. Translational vision science & technology 2 37351895
2025 Optimization of environmental and energy performance of egg production using data envelopment analysis (DEA) and life cycle assessment (LCA). The Science of the total environment 1 39824106
2025 NUT carcinoma of larynx with aberrant LCA expression: A rare entity with diagnostic and therapeutic challenge. Journal of cancer research and therapeutics 1 40214395
2025 The Microbial Bile Acid Metabolite 3-Oxo-LCA Inhibits Colorectal Cancer Progression. Cancer research 1 40960502
2025 Formulation and evaluation of probucol-LCA nanoparticles for supressing oxidative stress-related retinal degeneration. Drug delivery and translational research 1 41254279
2024 Generation of two hiPSC lines carrying compound heterozygous RDH12 mutations in a LCA patient. Stem cell research 1 39142122
2017 [Gene therapy for vision restoration in patients with Leber congenital amaurosis (LCA) due to RPE65 gene mutations: beginning the phase IV trial]. Gaceta medica de Mexico 1 28474714
2005 [From gene to disease; Leber congenital amaurosis (LCA)]. Nederlands tijdschrift voor geneeskunde 1 16261712
2026 LCA and 3-oxo-LCA mitigate dietary oxysterols-induced loss of barrier function in intestinal epithelial cells. Steroids 0 41616898
2025 Assessment of the environmental, health and economic linkages of traditional tapas in Spain: A cluster and LCA approach. The Science of the total environment 0 40187085
2025 Identification and validation of TUBB, CLTA, and FBXL5 as potential diagnostic markers of postmenopausal osteoporosis. Biomolecules & biomedicine 0 40791155
2025 Therapeutic potential of allogeneic iPS cell-derived RPE transplantation for RPE65-LCA. American journal of ophthalmology case reports 0 40852473
2025 Disruption of the gut microbiota induces the LCA/TRPV6 signalling axis, impairing desmosome junctions in vitamin A-deficient rats. Food research international (Ottawa, Ont.) 0 41267264
2025 EGCG alleviates colitis in inflammatory bowel disease via gut microbiota-derived LCA and inhibition of NLRP3 inflammasome. International immunopharmacology 0 41330168
2025 Optimization of rural green building design in Northwestern Hunan based on LCA and AHP. Scientific reports 0 41353251
2024 Abnormal expression of LCA and CD43 in SCLC: a rare case report and brief literature review. BMC pulmonary medicine 0 38649942
2024 QF-LCA dataset: Quantum Field Lens Coding Algorithm for system state simulation and strong predictions. Data in brief 0 39678445