- Length
- 1675 aa
- Mass
- 191.6 kDa
- Annotated
- 2026-06-09
100 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 100 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1988 | Thyroid hormone receptor alpha isoforms generated by alternative splicing differentially activate myosin HC gene transcription. | Nature | 435 | 2841611 |
| 2008 | HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. | Molecular pain | 381 | 18954467 |
| 2022 | The BlueScreen HC assay to predict the genotoxic potential of fragrance materials. | Mutagenesis | 364 | 35302169 |
| 1985 | Homology of beta-lactoglobulin, serum retinol-binding protein, and protein HC. | Science (New York, N.Y.) | 235 | 2580349 |
| 2003 | A novel CLTC-TFE3 gene fusion in pediatric renal adenocarcinoma with t(X;17)(p11.2;q23). | Oncogene | 215 | 12917640 |
| 1992 | Diagnostic value of analysis of cystatin C and protein HC in biological fluids. | Clinical nephrology | 205 | 1284235 |
| 2007 | The conserved FRNK box in HC-Pro, a plant viral suppressor of gene silencing, is required for small RNA binding and mediates symptom development. | Journal of virology | 150 | 17898058 |
| 2008 | EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. | Lung cancer (Amsterdam, Netherlands) | 135 | 18242762 |
| 2006 | HC-toxin. | Phytochemistry | 134 | 16839576 |
| 2003 | ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma. | Blood | 134 | 12750159 |
| 2003 | Structural characterization of HC-Pro, a plant virus multifunctional protein. | The Journal of biological chemistry | 118 | 12684502 |
| 2016 | HC-HA/PTX3 Purified From Amniotic Membrane as Novel Regenerative Matrix: Insight Into Relationship Between Inflammation and Regeneration. | Investigative ophthalmology & visual science | 115 | 27116665 |
| 2009 | Biochemical characterization and function of complexes formed by hyaluronan and the heavy chains of inter-alpha-inhibitor (HC*HA) purified from extracts of human amniotic membrane. | The Journal of biological chemistry | 113 | 19491101 |
| 2018 | Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. | PloS one | 110 | 29385160 |
| 1992 | Alpha 1-microglobulin (protein HC): features of a promising indicator of proximal tubular dysfunction. | European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies | 86 | 1283528 |
| 2002 | C-F...H-C hydrogen bonds in ribonucleic acids. | Journal of the American Chemical Society | 83 | 12010039 |
| 2013 | Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability. | Journal of biotechnology | 80 | 23583871 |
| 1986 | Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis. | Proceedings of the National Academy of Sciences of the United States of America | 78 | 2419908 |
| 2008 | HC-Pro protein of sugar cane mosaic virus interacts specifically with maize ferredoxin-5 in vitro and in planta. | The Journal of general virology | 73 | 18632977 |
| 2008 | Cortactin (CTTN), N-WASP (WASL), and clathrin (CLTC) are present at podosome-like tubulobulbar complexes in the rat testis. | Biology of reproduction | 68 | 18799755 |
| 2000 | Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization. | Osteoarthritis and cartilage | 63 | 10772238 |
| 1986 | The molecular organization of the protein HC-IgA complex (HC-IgA). | The Journal of biological chemistry | 63 | 2429955 |
| 2012 | Constitutive expression of inter-α-inhibitor (IαI) family proteins and tumor necrosis factor-stimulated gene-6 (TSG-6) by human amniotic membrane epithelial and stromal cells supporting formation of the heavy chain-hyaluronan (HC-HA) complex. | The Journal of biological chemistry | 62 | 22351758 |
| 2007 | The HC-pro protein of potato virus Y interacts with NtMinD of tobacco. | Molecular plant-microbe interactions : MPMI | 62 | 17990958 |
| 1995 | Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus. | Virology | 60 | 7747479 |
| 2003 | ALK+, CD30-, CD20- large B-cell lymphoma containing anaplastic lymphoma kinase (ALK) fused to clathrin heavy chain gene (CLTC). | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc | 59 | 12920229 |
| 2014 | Constitutive expression of pentraxin 3 (PTX3) protein by human amniotic membrane cells leads to formation of the heavy chain (HC)-hyaluronan (HA)-PTX3 complex. | The Journal of biological chemistry | 58 | 24652286 |
| 2016 | Structural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences. | Scientific reports | 55 | 27874100 |
| 2007 | RANBP2 and CLTC are involved in ALK rearrangements in inflammatory myofibroblastic tumors. | Cancer genetics and cytogenetics | 55 | 17656252 |
| 2010 | Discriminating mutations of HC-Pro of zucchini yellow mosaic virus with differential effects on small RNA pathways involved in viral pathogenicity and symptom development. | Molecular plant-microbe interactions : MPMI | 52 | 19958135 |
| 2019 | HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells. | Journal of cellular and molecular medicine | 51 | 30884106 |
| 2019 | Long Noncoding RNA lnc-HC Regulates PPARγ-Mediated Hepatic Lipid Metabolism through miR-130b-3p. | Molecular therapy. Nucleic acids | 50 | 31770672 |
| 2005 | Structural analysis of tobacco etch potyvirus HC-pro oligomers involved in aphid transmission. | Journal of virology | 49 | 15731269 |
| 1999 | Non-viral neuronal gene delivery mediated by the HC fragment of tetanus toxin. | European journal of biochemistry | 47 | 10092862 |
| 2018 | Interaction between autophagic vesicles and the Coxiella-containing vacuole requires CLTC (clathrin heavy chain). | Autophagy | 45 | 29973118 |
| 2010 | Efficacy of a potential trivalent vaccine based on Hc fragments of botulinum toxins A, B, and E produced in a cell-free expression system. | Clinical and vaccine immunology : CVI | 45 | 20357058 |
| 2008 | Contrasting effects of HC-Pro and 2b viral suppressors from Sugarcane mosaic virus and Tomato aspermy cucumovirus on the accumulation of siRNAs. | Virology | 45 | 18280529 |
| 2019 | The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice. | European journal of pharmacology | 44 | 31129158 |
| 2009 | Structural and functional characterisation of the fork head transcription factor-encoding gene, Hc-daf-16, from the parasitic nematode Haemonchus contortus (Strongylida). | International journal for parasitology | 44 | 19796644 |
| 2008 | Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells. | International journal of cancer | 44 | 18074352 |
| 2011 | Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas. | PloS one | 42 | 21494621 |
| 2003 | HC gp-39 gene is upregulated in glioblastomas. | Cancer letters | 40 | 12957359 |
| 2001 | Resistance of RNA-mediated TGS to HC-Pro, a viral suppressor of PTGS, suggests alternative pathways for dsRNA processing. | Current biology : CB | 39 | 11509235 |
| 2017 | Recombinant Botulinum Neurotoxin Hc Subunit (BoNT Hc) and Catalytically Inactive Clostridium botulinum Holoproteins (ciBoNT HPs) as Vaccine Candidates for the Prevention of Botulism. | Toxins | 37 | 28869522 |
| 1994 | Human protein HC (alpha 1-microglobulin) and inter-alpha-trypsin inhibitor in connective tissue. | The Histochemical journal | 37 | 7533752 |
| 2019 | 25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway. | International journal of oncology | 36 | 30664194 |
| 1988 | Identification of the protein HC receptor. | FEBS letters | 36 | 2457516 |
| 2020 | HC-HA/PTX3 Purified From Human Amniotic Membrane Reverts Human Corneal Fibroblasts and Myofibroblasts to Keratocytes by Activating BMP Signaling. | Investigative ophthalmology & visual science | 35 | 32462202 |
| 2016 | CLTC as a clinically novel gene associated with multiple malformations and developmental delay. | American journal of medical genetics. Part A | 35 | 26822784 |
| 2003 | Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell. | The Journal of biological chemistry | 35 | 12855681 |
| 1990 | Location and characterization of the three carbohydrate prosthetic groups of human protein HC. | FEBS letters | 33 | 1694784 |
| 2010 | Helper component-proteinase (HC-Pro) protein of Papaya ringspot virus interacts with papaya calreticulin. | Molecular plant pathology | 32 | 20447282 |
| 1991 | Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter. | Genomics | 31 | 1765375 |
| 2007 | Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04. | Toxicology in vitro : an international journal published in association with BIBRA | 30 | 17590308 |
| 2006 | HC-gp39 contributes to chondrocyte differentiation by inducing SOX9 and type II collagen expressions. | Osteoarthritis and cartilage | 30 | 16949314 |
| 1999 | Vitamin D3 receptor (VDR) expression in HC-11 mammary cells: regulation by growth-modulatory agents, differentiation, and Ha-ras transformation. | Breast cancer research and treatment | 30 | 10424403 |
| 2022 | Adhesion and Colonization of the Probiotic Lactobacillus plantarum HC-2 in the Intestine of Litopenaeus Vannamei Are Associated With Bacterial Surface Proteins. | Frontiers in microbiology | 28 | 35535252 |
| 2014 | Hc-daf-2 encodes an insulin-like receptor kinase in the barber's pole worm, Haemonchus contortus, and restores partial dauer regulation. | International journal for parasitology | 28 | 24727120 |
| 2023 | PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors. | Clinical cancer research : an official journal of the American Association for Cancer Research | 27 | 37733811 |
| 2020 | A novel CLTC-FOSB gene fusion in pseudomyogenic hemangioendothelioma of bone. | Genes, chromosomes & cancer | 27 | 32749039 |
| 1977 | Expression of protein HC on the plasma membrane of different human cell types. | Journal of immunology (Baltimore, Md. : 1950) | 27 | 330755 |
| 2021 | The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite Plasmodium falciparum. | iScience | 26 | 33997710 |
| 2013 | CLTC-ALK fusion as a primary event in congenital blastic plasmacytoid dendritic cell neoplasm. | Genes, chromosomes & cancer | 26 | 24142740 |
| 2009 | Compensatory molecular evolution of HC-Pro, an RNA-silencing suppressor from a plant RNA virus. | Molecular biology and evolution | 26 | 19906792 |
| 2011 | ALK-positive extramedullary plasmacytoma with expression of the CLTC-ALK fusion transcript. | Pathology, research and practice | 25 | 21855232 |
| 2001 | HC fragment (C-terminal portion of the heavy chain) of tetanus toxin activates protein kinase C isoforms and phosphoproteins involved in signal transduction. | The Biochemical journal | 25 | 11336640 |
| 2006 | Biochemical and pre-steady-state kinetic characterization of the hepatitis C virus RNA polymerase (NS5BDelta21, HC-J4). | Biochemistry | 24 | 16533043 |
| 2003 | Role of HPV DNA testing in predicting cervical intraepithelial lesions: comparison of HC HPV and ISH HPV. | Diagnostic cytopathology | 24 | 12951683 |
| 1999 | A putative branched-chain-amino-acid transaminase gene required for HC-toxin biosynthesis and pathogenicity in Cochliobolus carbonum. | Microbiology (Reading, England) | 24 | 10627051 |
| 2020 | The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p. | Molecular therapy. Nucleic acids | 22 | 32278306 |
| 2012 | The GADD45a-GFP GreenScreen HC assay. | Methods in molecular biology (Clifton, N.J.) | 22 | 22147576 |
| 2020 | Investigation of the effects of P1 on HC-pro-mediated gene silencing suppression through genetics and omics approaches. | Botanical studies | 21 | 32748085 |
| 2010 | Expression and immunolocalization of aquaporins HC-1, -2, and -3 in Cope's gray treefrog, Hyla chrysoscelis. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology | 21 | 20416391 |
| 2010 | Mapping the self-interacting domains of TuMV HC-Pro and the subcellular localization of the protein. | Virus genes | 21 | 20938729 |
| 2021 | Hyaluronic acid synthesis, degradation, and crosslinking in equine osteoarthritis: TNF-α-TSG-6-mediated HC-HA formation. | Arthritis research & therapy | 20 | 34416923 |
| 2020 | Niche regulation of limbal epithelial stem cells: HC-HA/PTX3 as surrogate matrix niche. | Experimental eye research | 20 | 32795525 |
| 2010 | HC-Pro, a potyvirus RNA silencing suppressor, cancels cycling of Cucumber mosaic virus in Nicotiana benthamiana plants. | Virus genes | 20 | 20162445 |
| 2022 | Molecular investigation of ALK-rearranged epithelioid fibrous histiocytomas identifies CLTC as a novel fusion partner and evidence of fusion-independent transcription activation. | Genes, chromosomes & cancer | 19 | 35289445 |
| 2022 | Cell surface-associated protein elongation factor Tu interacts with fibronectin mediating the adhesion of Lactobacillus plantarum HC-2 to Penaeus vannamei intestinal epithelium and inhibiting the apoptosis induced by LPS and pathogen in Caco-2 cells. | International journal of biological macromolecules | 19 | 36442565 |
| 2021 | Investigating the Viral Suppressor HC-Pro Inhibiting Small RNA Methylation through Functional Comparison of HEN1 in Angiosperm and Bryophyte. | Viruses | 19 | 34578418 |
| 2020 | A Novel Vibriophage vB_VcaS_HC Containing Lysogeny-Related Gene Has Strong Lytic Ability against Pathogenic Bacteria. | Virologica Sinica | 19 | 32767211 |
| 2019 | De novo CLTC variants are associated with a variable phenotype from mild to severe intellectual disability, microcephaly, hypoplasia of the corpus callosum, and epilepsy. | Genetics in medicine : official journal of the American College of Medical Genetics | 19 | 31776469 |
| 2019 | 25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4. | American journal of cancer research | 18 | 31720079 |
| 2011 | High level expression of recombinant BoNT/A-Hc by high cell density cultivation of Escherichia coli. | Bioprocess and biosystems engineering | 18 | 21833619 |
| 1994 | Location of a novel type of interpolypeptide chain linkage in the human protein HC-IgA complex (HC-IgA) and identification of a heterogeneous chromophore associated with the complex. | The Journal of biological chemistry | 18 | 7506257 |
| 2014 | Hc-fau, a novel gene regulating diapause in the nematode parasite Haemonchus contortus. | International journal for parasitology | 17 | 25058511 |
| 2021 | Phase I clinical trial of HC-1119: A deuterated form of enzalutamide. | International journal of cancer | 16 | 34109624 |
| 2020 | A Spontaneous Complementary Mutation Restores the RNA Silencing Suppression Activity of HC-Pro and the Virulence of Sugarcane Mosaic Virus. | Frontiers in plant science | 16 | 32973838 |
| 2016 | Structural and functional characterization of a novel gene, Hc-daf-22, from the strongylid nematode Haemonchus contortus. | Parasites & vectors | 16 | 27472920 |
| 2021 | Derma-Hc, a New Developed Herbal Formula, Ameliorates Cutaneous Lichenification in Atopic Dermatitis. | International journal of molecular sciences | 15 | 33652999 |
| 2012 | Characterisation of the cell line HC-AFW1 derived from a pediatric hepatocellular carcinoma. | PloS one | 15 | 22666492 |
| 2002 | Fluorescent probes DPH, TMA-DPH and C17-HC induce erythrocyte exovesiculation. | The Journal of membrane biology | 15 | 12422273 |
| 2024 | Gene copy number, gene configuration and LC/HC mRNA ratio impact on antibody productivity and product quality in targeted integration CHO cell lines. | Biotechnology progress | 14 | 38321634 |
| 2015 | HC toxin (a HDAC inhibitor) enhances IRS1-Akt signalling and metabolism in mouse myotubes. | Journal of molecular endocrinology | 14 | 26373795 |
| 1988 | Measurement of protein HC (alpha 1 microglobulin) and protein HC-IgA complex in different body fluids. | Journal of clinical pathology | 14 | 2463270 |
| 2014 | The acute transcriptomic and proteomic response of HC-04 hepatoma cells to hepatocyte growth factor and its implications for Plasmodium falciparum sporozoite invasion. | Molecular & cellular proteomics : MCP | 13 | 24532842 |
| 2011 | The candidate Fu/HC gene in Botryllusschlosseri (Urochordata) and ascidians' historecognition--an oxymoron? | Developmental and comparative immunology | 13 | 22085780 |
| 2003 | Introduction of a NIa proteinase cleavage site between the reporter gene and HC-Pro only partially restores the biological properties of GUS- or GFP-tagged LMV. | Virus research | 13 | 14659562 |
| 2024 | Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator. | Journal of medicinal chemistry | 12 | 38530741 |
| 2021 | Deregulation of CLTC interacts with TFG, facilitating osteosarcoma via the TGF-beta and AKT/mTOR signaling pathways. | Clinical and translational medicine | 12 | 34185412 |
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