Affinage

CAPZB

F-actin-capping protein subunit beta · UniProt P47756

Round 2 corrected
Length
272 aa
Mass
30.6 kDa
Annotated
2026-04-28
102 papers in source corpus 18 papers cited in narrative 18 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CAPZB encodes the beta subunit of the heterodimeric F-actin capping protein (CapZ), which binds and caps actin filament barbed ends through a C-terminal actin-binding domain containing two critical conserved leucine residues, thereby controlling filament elongation, cortical tension, and actomyosin contractility (PMID:7665558, PMID:28530659). As a stable component of the endosomal WASH complex, the CAPZA–CAPZB heterodimer facilitates Arp2/3-dependent actin nucleation on endosomes and regulates MVB trafficking for exosome secretion via ALIX-mediated recruitment (PMID:19922875, PMID:40185104). CAPZB concentrates at stereocilia tips in hair cells where mechanotransduction channel activity specifies its localization to govern stereocilia dimensions and auditory/vestibular function, and in hepatocytes it restrains ROCK–myosin-driven contractility to limit YAP activation and maintain liver size and metabolic zonation (PMID:28899994, PMID:31902726, PMID:30878582). Beyond actin capping, CAPZB regulates spindle orientation by controlling dynein/dynactin complex assembly at the cell cortex, and loss-of-function in zebrafish causes craniofacial and muscle defects linked to impaired neural crest migration (PMID:28803871, PMID:26758871).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1995 High

    Identification of CAPZB's C-terminal actin-binding domain and critical residues established the molecular basis of barbed-end capping by the heterodimeric CapZ complex.

    Evidence Site-directed mutagenesis of conserved leucines combined with F-actin cosedimentation assay

    PMID:7665558

    Open questions at the time
    • No structural model of the CAPZB–actin interface at atomic resolution from this study
    • Regulatory mechanisms controlling capping activity in vivo were unknown
  2. 2009 High

    Discovery that CAPZB resides in the endosomal WASH complex and that a spermatid-specific isoform pairs with CAPZA3 revealed that CAPZB functions extend beyond sarcomeric capping to endosomal actin nucleation and germ cell morphogenesis.

    Evidence Affinity purification/MS of WASH complex with in vitro Arp2/3 activation reconstitution; ENU mouse mutant and spermatid immunofluorescence

    PMID:19341723 PMID:19922875

    Open questions at the time
    • How CAPZB is specifically recruited to endosomal versus sarcomeric sites was unresolved
    • Whether the spermatid isoform has distinct capping kinetics was not tested
  3. 2013 High

    Identification of QK as the splicing factor promoting Capzb exon 9 inclusion during myogenesis, opposing PTB repression, showed that tissue-specific CAPZB isoform diversity is under regulated alternative splicing control.

    Evidence RNA affinity chromatography/MS plus RNAi knockdown with splicing profiling in differentiating myoblasts

    PMID:23525800

    Open questions at the time
    • Functional consequences of exon 9 inclusion for capping activity were not determined
    • Whether QK-dependent splicing operates in non-muscle lineages was not tested
  4. 2016 High

    Demonstration that CAPZB controls mitotic spindle orientation through dynein/dynactin assembly independently of actin capping revealed a non-canonical function in microtubule-based processes, validated in vertebrate neuroepithelium.

    Evidence RNAi in micropatterned cells, live-cell imaging, dynein/dynactin complex analysis, in vivo neuroepithelium validation

    PMID:28803871

    Open questions at the time
    • Molecular mechanism by which CAPZB modulates dynein/dynactin motor activity remains unclear
    • Whether this function requires CAPZA heterodimerization was not addressed
  5. 2016 High

    Zebrafish capzb null mutants linked capping protein to neural crest migration, craniofacial morphogenesis, and myogenic differentiation, connecting CAPZB to developmental phenotypes resembling human micrognathia/cleft palate.

    Evidence Zebrafish genetic knockout with live neural crest imaging plus human translocation patient whole-genome sequencing

    PMID:26758871

    Open questions at the time
    • Direct causative human mutations in CAPZB for craniofacial disorders are not established beyond a single translocation case
    • Downstream transcriptional or signaling effects in neural crest cells were not dissected
  6. 2017 High

    Conditional Capzb deletion in hair cells and biophysical measurements of mitotic cortex tension established that CAPZB is essential for stereocilia maintenance and that the mitotic cortex is poised near a tension maximum tuned by capping protein levels.

    Evidence Conditional KO (Atoh1-Cre) with quantitative fluorescence and functional auditory/vestibular testing; RNAi with micropipette aspiration tension measurements

    PMID:28530659 PMID:28899994

    Open questions at the time
    • How CAPZB cooperates with TWF2 to control individual stereocilia row identity was only partially resolved
    • Whether cortical tension tuning is relevant outside mitosis was not examined
  7. 2019 High

    Hepatocyte-specific Capzb knockout demonstrated that capping protein restrains actomyosin contractility to limit YAP-driven proliferation, maintaining liver size, hepatocyte differentiation, and metabolic zonation.

    Evidence Conditional KO mice with traction force microscopy, YAP immunostaining, ROCK inhibitor rescue, and genetic epistasis with Yap1 deletion

    PMID:30878582

    Open questions at the time
    • Whether CAPZB similarly limits YAP mechanotransduction in other epithelial organs is untested
    • Direct phosphorylation or regulatory inputs that tune hepatocyte CAPZB activity are unknown
  8. 2020 High

    Mechanotransduction channel activity (TMC1/2, TMIE) was shown to specify CAPZB and TWF2 enrichment at row 2 stereocilia tips, linking sensory transduction to actin remodeling programs that establish stereocilia row identity.

    Evidence Genetic KOs of Tmc1/Tmc2 and Tmie plus pharmacological channel block with immunofluorescence localization

    PMID:31902726

    Open questions at the time
    • Signaling intermediate between channel current and CAPZB localization is unknown
    • Whether calcium influx alone is sufficient to direct CAPZB enrichment was not resolved
  9. 2025 Medium

    ALIX-mediated recruitment of CAPZA1/CAPZB to MVBs was shown to suppress branched actin accumulation, enabling MVB peripheral trafficking and exosome release rather than lysosomal degradation.

    Evidence Co-IP, proximity ligation, F-actin imaging around MVBs, genetic depletion/overexpression in mouse and human cancer cells

    PMID:40185104

    Open questions at the time
    • Whether CAPZB capping of branched actin requires WASH complex interaction at MVBs or is independent
    • In vivo validation of the ALIX–CAPZB axis in exosome secretion is lacking
    • Single study — independent replication pending

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of CAPZB's actin-independent control of dynein/dynactin, the signaling intermediates linking mechanotransduction to CAPZB stereocilia tip enrichment, and whether post-translational modifications (TORC2 phosphorylation, N-α-acetylation via Btbd3) represent general regulatory mechanisms across tissues.
  • No high-resolution structure of CAPZB in complex with dynein/dynactin
  • Tissue-specific regulatory inputs to CAPZB activity are fragmentary
  • Comprehensive phosphosite mapping in mammalian systems is lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 5 GO:0005198 structural molecule activity 3
Localization
GO:0005856 cytoskeleton 5 GO:0005886 plasma membrane 4 GO:0005768 endosome 2 GO:0005829 cytosol 2 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-1640170 Cell Cycle 2 R-HSA-5653656 Vesicle-mediated transport 2 R-HSA-9709957 Sensory Perception 2 R-HSA-162582 Signal Transduction 1 R-HSA-8953854 Metabolism of RNA 1
Partners
ALIXBTBD3CAPZA1CAPZA2CAPZA3QKITWF2WASH1
Complex memberships
CapZ heterodimer (CAPZA/CAPZB)WASH complexdynein/dynactin complex

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 Human CAPZB encodes the beta subunit of the heterodimeric capping protein Cap Z; the C-terminal domain of CAPZB contains the actin-binding region, and amino acid substitutions of two conserved leucines in the chicken beta subunit significantly decreased F-actin binding activity. The human CAPZB gene was mapped to chromosome 1p36.1. F-actin cosedimentation assay, site-directed mutagenesis, chromosomal mapping The Journal of biological chemistry High 7665558
2009 A unique spermatid-specific CAPZB isoform forms a heterodimer with CAPZA3; disruption of CAPZA3 (via ENU-induced missense mutation in repro32 mice) alters CAPZB localization in spermatids and disrupts the F-actin network, causing failure of cytoplasm shedding and midpiece disorganization during spermiation. Candidate-gene sequencing, immunofluorescence localization in mouse spermatids, genetic mouse model (ENU mutant) Developmental biology High 19341723
2013 Quaking (QK) promotes inclusion of Capzb exon 9 during myoblast-to-myotube differentiation in opposition to repression by PTB; mass spectrometry of proteins binding the Capzb exon 9 intron identified QK as the key splicing factor, and QK depletion broadly alters cassette exon inclusion at ACUAA-containing introns. RNA affinity chromatography + mass spectrometry, RNAi knockdown, alternative splicing profiling RNA (New York, N.Y.) High 23525800
2013 CAPZB (Capzb) was identified as one of five F-actin end-binding proteins (along with Arpc2, Arpc4, Gsn, Scin) that change abundance at the apical plasma membrane of kidney collecting duct cells in response to vasopressin, suggesting a role in the actin remodeling that permits aquaporin-2 trafficking. Stable isotope quantitative proteomics, surface biotinylation, live-cell F-actin imaging Proceedings of the National Academy of Sciences of the United States of America Medium 24085853
2016 CAPZB controls spindle orientation independently of its classical actin-capping role by regulating the assembly, stability, and motor activity of the dynein/dynactin complex at the cell cortex and the dynamics of mitotic microtubules; CAPZB also controls planar divisions in the developing vertebrate neuroepithelium in vivo. RNAi screen in micropatterned cell model, live-cell imaging, dynein/dynactin complex analysis, in vivo neuroepithelium analysis Current biology : CB High 28803871
2016 Loss of capzb in zebrafish causes craniofacial and muscle defects recapitulating a human micrognathia/cleft palate phenotype; capzb is required for neural crest cell migration, differentiation of myogenic stem cells and neural crest cells, and palate morphogenesis, while capzb overexpression causes embryonic lethality. Zebrafish capzb null mutants, human whole-genome sequencing of translocation patient, live imaging of neural crest migration Human molecular genetics High 26758871
2016 CAPZB is functionally downstream of the SWI/SNF chromatin-remodeling complex component INI1 in epithelioid sarcoma; CAPZB silencing inhibits EpiS cell growth, invasion and migration, and INI1 induction increases CAPZB mRNA expression while CAPZB silencing decreases INI1 protein. siRNA knockdown, cell viability/migration/invasion assays, iTRAQ quantitative proteomics, IPA pathway analysis, INI1 overexpression BMC cancer Medium 26965049
2016 TORC2-dependent phosphorylation of fission yeast Acp1 (the CAPZA ortholog) controls cytokinetic actomyosin ring stability and modulates Acp1-Acp2 (equivalent to mammalian CAPZA-CAPZB) heterodimer formation; disruption of TORC2 localisation to the CAR impairs ring constriction. Fission yeast genetics, phosphoproteomics, co-IP, live imaging Journal of cell science Medium 27206859
2017 CAPZB is present at ~100 copies per stereocilium and concentrates at stereocilia tips as hair cell development progresses; conditional Capzb deletion in hair cells eliminates auditory and vestibular function, and Capzb-null stereocilia initially develop normally but then shorten, disappear, and decrease in width, indicating CAPZB participates in stereocilia widening by preventing newly elongating actin filaments from depolymerizing. Conditional Capzb knockout (Atoh1-Cre), immunofluorescence, in utero electroporation of CAPZB2, quantitative fluorescence imaging The Journal of cell biology High 28899994
2017 CAPZB, alongside CFL1 and DIAPH1, regulates mitotic cortex thickness and cortical tension; both increasing and decreasing actin filament length (by manipulating these capping/severing proteins) reduces cortical tension, indicating the mitotic cortex is poised near a tension maximum. RNAi knockdown, cortex thickness measurement by fluorescence, cortical tension measurement by micropipette aspiration, computational modeling Nature cell biology High 28530659
2018 CAPZB was identified as a binding partner of Chikungunya virus nsP3 HVD by quantitative proteomics; CAPZB and CAPZA1/CAPZA2 interact with the nsP3 HVD of CHIKV in human cells. EGFP-tagged nsP3 HVD expression, quantitative proteomics pulldown Viruses Low 29702546
2019 CAPZ (CAPZB) restrains actomyosin contractility in hepatocytes: conditional Capzb knockout in mouse liver alters stress fiber and focal adhesion dynamics, enhances myosin activity, increases traction forces and liver stiffness, activates YAP in parallel to the Hippo pathway, causing hepatocyte proliferation, organ overgrowth, loss of hepatocyte differentiation, metabolic zonation defects, and gluconeogenesis impairment. ROCK inhibition or Yap1 deletion reverses these phenotypes. Conditional Capzb knockout mice (hepatocyte-specific), traction force microscopy, YAP immunostaining, hydrodynamic tail vein injection, ROCK inhibitor treatment, genetic epistasis with Yap1 deletion Journal of hepatology High 30878582
2019 A genome-wide CRISPR knockout screen identified CAPZB as a host factor required for Salmonella uptake in human macrophages; loss of CAPZB (along with other actin dynamics genes) confers resistance to Salmonella invasion. Genome-scale CRISPR KO library screen in THP-1 macrophages mBio Medium 31594818
2020 Mechanotransduction in inner hair cells specifies CAPZB localization: CAPZB and its partner TWF2 normally concentrate at row 2 stereocilia tips, but this concentration is lost in transduction mutants (Tmc1/Tmc2 or Tmie knockouts) or when transduction channels are blocked pharmacologically, demonstrating that transduction channel activity controls CAPZB distribution and stereocilia row identity. Genetic mouse knockouts (Tmc1, Tmc2, Tmie), pharmacological channel block, immunofluorescence localization of CAPZB and TWF2 Current biology : CB High 31902726
2009 CAPZB belongs to the WASH multiprotein complex on endosomes; the WASH complex (containing the CAPZ heterodimer) activates Arp2/3-mediated actin nucleation in vitro and its purified form binds directly to liposomes, with WASH depletion causing endosomal membrane tubulation and impaired transferrin recycling. Affinity purification/MS identification of WASH complex, in vitro Arp2/3 actin nucleation assay, liposome binding assay, RNAi knockdown with tubulation phenotype Developmental cell High 19922875
2025 ALIX recruits actin-capping proteins CAPZA1/CAPZB to prevent branched filamentous actin (F-actin) accumulation around multivesicular bodies (MVBs), enabling MVB trafficking to the cell periphery for exosome secretion; PTPN23 competes with ALIX for syntenin binding and directs MVBs toward lysosomal degradation instead. Co-IP, proximity ligation, F-actin imaging around MVBs, genetic depletion/overexpression in mouse and human cancer cells Developmental cell Medium 40185104
2024 NAA10-mediated N-α-acetylation of Btbd3 promotes CapZb binding to F-actin in hippocampal neurons; disrupting the Btbd3/CapZb interaction (by Naa10 knockout or N-α-acetylation-defective Btbd3 mutant) reduces CapZb binding to F-actin and decreases neurite outgrowth, which is rescued by cytochalasin D (mimicking barbed-end capping). Hippocampal CA1-specific Naa10 knockout mice, co-IP, N-α-acetylation mutagenesis, neurite length measurement, pharmacological rescue with cytochalasin D bioRxivpreprint Medium bio_10.1101_2024.05.09.583166
2012 CAPZB protein is detected in amphioxus striated muscle, where CapZα and CapZβ are encoded by two separate genes (CAPZA and CAPZB) sharing 67–85% transcript identity with human Cap Z genes, demonstrating evolutionary conservation of the heterodimeric capping protein in chordate striated muscle. Western blotting of amphioxus striated muscle, genome mining, transcript analysis Gene Low 22951807

Source papers

Stage 0 corpus · 102 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2009 Defining the human deubiquitinating enzyme interaction landscape. Cell 1282 19615732
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 Large-scale proteomics and phosphoproteomics of urinary exosomes. Journal of the American Society of Nephrology : JASN 607 19056867
2017 Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.) 533 28302793
2003 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nature biotechnology 485 12665801
2009 The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Developmental cell 472 19922875
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2004 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. The Biochemical journal 372 14744259
2015 Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry. Nature methods 370 26414014
2007 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Molecular cell 367 17643375
2017 Actin cortex architecture regulates cell surface tension. Nature cell biology 307 28530659
2006 A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell 302 16678097
2012 Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. American journal of human genetics 275 22482804
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
2012 The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. Cell 272 23084401
2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nature biotechnology 266 15146197
2011 A directed protein interaction network for investigating intracellular signal transduction. Science signaling 258 21900206
2009 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Journal of proteome research 237 19199708
2013 Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiation. RNA (New York, N.Y.) 133 23525800
2023 Pan-cancer genetic analysis of disulfidptosis-related gene set. Cancer genetics 124 37879141
2019 F-actin dynamics regulates mammalian organ growth and cell fate maintenance. Journal of hepatology 68 30878582
2017 Whole genome scan reveals the genetic signature of African Ankole cattle breed and potential for higher quality beef. BMC genetics 67 28183280
2013 Quantitative apical membrane proteomics reveals vasopressin-induced actin dynamics in collecting duct cells. Proceedings of the National Academy of Sciences of the United States of America 60 24085853
2020 Mechanotransduction-Dependent Control of Stereocilia Dimensions and Row Identity in Inner Hair Cells. Current biology : CB 59 31902726
2009 A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice. Developmental biology 56 19341723
1995 Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. The Journal of biological chemistry 54 7665558
2012 Identification of differentially expressed proteins between bull X and Y spermatozoa. Journal of proteomics 50 22820535
2017 Heterodimeric capping protein is required for stereocilia length and width regulation. The Journal of cell biology 45 28899994
2019 A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection. mBio 43 31594818
2011 Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. American journal of human genetics 43 21565293
2010 A locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study. American journal of human genetics 42 20826269
2009 Porcine muscle sensory attributes associate with major changes in gene networks involving CAPZB, ANKRD1, and CTBP2. Functional & integrative genomics 39 19597856
2018 Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus. Viruses 38 29702546
2020 Label free shotgun proteomics for the identification of protein biomarkers for beef tenderness in muscle and plasma of heifers. Journal of proteomics 35 32058039
2021 Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD 34 33252074
2016 Actin capping protein CAPZB regulates cell morphology, differentiation, and neural crest migration in craniofacial morphogenesis†. Human molecular genetics 33 26758871
2012 Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function. Human molecular genetics 33 22494929
2018 Characterization of the effects of trace concentrations of graphene oxide on zebrafish larvae through proteomic and standard methods. Ecotoxicology and environmental safety 30 29753824
2017 Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90. PloS one 28 28056051
2014 2D-DIGE proteome analysis on the platelet proteins of patients with major depression. Proteome science 27 24383611
2018 Proteomic pattern of implantative human endometrial fluid in in vitro fertilization cycles. Archives of gynecology and obstetrics 26 29637268
2011 Reduction in antioxidant enzyme expression and sustained inflammation enhance tissue damage in the subacute phase of spinal cord contusive injury. Journal of biomedical science 26 21299884
2014 Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations. Human molecular genetics 25 24852370
2021 Bull Sperm Capacitation Is Accompanied by Redox Modifications of Proteins. International journal of molecular sciences 24 34360666
2023 Non-allergic eye rubbing is a major behavioral risk factor for keratoconus. PloS one 23 37053215
2015 Proteomic analysis reveals that the protective effects of ginsenoside Rb1 are associated with the actin cytoskeleton in β-amyloid-treated neuronal cells. Journal of ginseng research 23 27616904
2021 ViaFuse: Fiji macros to calculate skeletal muscle cell viability and fusion index. Skeletal muscle 22 34915930
2018 Pretreatment with cholesterol-loaded cyclodextrins prevents loss of motility associated proteins during cryopreservation of addra gazelle (Nanger dama ruficollis) spermatozoa. Cryobiology 21 29458042
2021 Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20 34004362
2016 Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma. Oncotarget 19 27391153
2020 The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies? FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18 32619075
2016 TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis. Journal of cell science 18 27206859
2016 Expression of F-actin-capping protein subunit beta, CAPZB, is associated with cell growth and motility in epithelioid sarcoma. BMC cancer 15 26965049
2018 Expression pattern of prohibitin, capping actin protein of muscle Z-line beta subunit and tektin-2 gene in Murrah buffalo sperm and its relationship with sperm motility. Asian-Australasian journal of animal sciences 14 29642674
2017 An RNAi Screen in a Novel Model of Oriented Divisions Identifies the Actin-Capping Protein Z β as an Essential Regulator of Spindle Orientation. Current biology : CB 13 28803871
1997 Fine mapping of 39 ESTs on human chromosome 6p23-p25. Genomics 12 9417921
2023 Genome-Wide Analysis of Sheep Artificially or Naturally Infected with Gastrointestinal Nematodes. Genes 11 37510248
2021 Effect of 2-Cys Peroxiredoxins Inhibition on Redox Modifications of Bull Sperm Proteins. International journal of molecular sciences 11 34884692
2017 Differential expression pattern of protein markers for predicting chemosensitivity of dexamethasone-based chemotherapy of B cell acute lymphoblastic leukemia. Cancer chemotherapy and pharmacology 11 28585036
2021 Proteomic Analysis Identifies Potential Markers for Chicken Primary Follicle Development. Animals : an open access journal from MDPI 9 33924300
2012 Actin capping proteins, CapZ (β-actinin) and tropomodulin in amphioxus striated muscle. Gene 9 22951807
2024 Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract. Frontiers in ophthalmology 8 38984127
2015 Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients. International journal of endocrinology 8 26273293
2020 Genome-wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma. Oncology letters 7 33133257
2024 Effect of cholesterol-loaded cyclodextrin treatment on boar sperm cryopreservation. Animal bioscience 6 38754842
2020 A new 1p36.13-1p36.12 microdeletion syndrome characterized by learning disability, behavioral abnormalities, and ptosis. Clinical genetics 6 32170730
2017 Genetic analysis of VCP and WASH complex genes in a German cohort of sporadic ALS-FTD patients. Neurobiology of aging 6 28551275
2017 Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS). Pharmacogenetics and genomics 6 28727628
2025 Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies. Developmental cell 5 40185104
2014 Identification and characterization of a differentially expressed protein (CAPZB) in skeletal muscle between Meishan and Large White pigs. Gene 5 24792893
2008 Investigation of eight candidate genes on chromosome 1p36 for autosomal dominant total congenital cataract. Molecular vision 5 18843385
2024 New insights into the hypothalamic-pituitary-thyroid axis: a transcriptome- and proteome-wide association study. European thyroid journal 4 38805593
2024 Novel insights of disulfidptosis-mediated immune microenvironment regulation in atherosclerosis based on bioinformatics analyses. Scientific reports 4 39521794
2025 Exploring a novel risk model based on core disulfidptosis-related genes in periodontitis: Bioinformatics analyses and experimental validation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 3 39924928
2025 Proteomic insights into lymph node metastasis in breast cancer subtypes: Key biomarkers and pathways. Pathology, research and practice 3 40179440
2018 Subclinical thyroid disease and single nucleotide polymorphisms in reproductive-age women in areas of Shanxi Province, China, where iodine exposure is excessive. Asia Pacific journal of clinical nutrition 3 30485936
2024 Activation of AMPK in platelets promotes the production of offspring. Platelets 2 38630016
2024 CAPZB mRNA is a novel biomarker for cervical high-grade squamous lesions. Scientific reports 2 39209986
2024 Identification and validation of differentially expressed disulfidptosis-related genes in hypertrophic cardiomyopathy. Molecular medicine (Cambridge, Mass.) 2 39701955
2024 Disulfidptosis and Its Hub Gene Slc3a2 Involved in Ulcerative Colitis Pathogenesis, Disease Progression, and Patient Responses to Biologic Therapies. International journal of molecular sciences 2 39769269
2022 Transcriptome-wide association study identifies multiple genes and pathways associated with thyroid function. Human molecular genetics 2 34962261
2025 Genetic Variants Related to TGF-β Signaling Pathway Modulate Risk of Meniscus Injury: A Multiancestry Genome-wide Association Study. Clinical orthopaedics and related research 1 40971882
2026 Identification of a novel real-time PCR reference gene panel for EA.hy926 endothelial cells in different growth States and with DHA treatment. Scientific reports 0 41559137
2026 Epitranscriptomic signatures of m5C, m6A, and pseudouridine in COVID-19 reveal host RNA modifications involved in viral pathogenesis. Microbiology spectrum 0 41586584
2025 Genome-wide DNA methylation and transcriptome sequencing analyses of lens tissue in an age-related mouse cataract model. PloS one 0 39883715
2025 Transcriptome profiling and alternative splicing analysis of skeletal muscle in Pseudocaranx dentex: insights into slow-twitch and fast-twitch muscle specialization. International journal of biological macromolecules 0 40360119
2025 Stage-Specific Serum Proteomic Signatures Reveal Early Biomarkers and Molecular Pathways in Huntington's Disease Progression. Cells 0 40801627
2025 Polymorphism as Biomarker Analysis of Genes TSHR, DIO1, FOXE1, and CAPZB in Hypothyroidism Patients. Endocrine research 0 40963443
2025 Exploring Genetic Markers for Cold-Heat Patterns: Integrating Traditional Medicine With Modern Genomic Research. Genetics research 0 41322252