Affinage

CAPZB

F-actin-capping protein subunit beta · UniProt P47756

Length
272 aa
Mass
30.6 kDa
Annotated
2026-06-09
73 papers in source corpus 14 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CAPZB encodes the β subunit of the heterodimeric F-actin barbed-end capping protein (CapZ), which binds F-actin through C-terminal residues—two conserved leucines being critical for binding activity—and pairs with a CAPZA α subunit to cap filament barbed ends and thereby set actin filament length (PMID:7665558, PMID:27206859). By limiting barbed-end elongation, CAPZB controls the architecture and mechanics of actin networks: it tunes mitotic cortex thickness and cortical tension (PMID:28530659), and restrains actomyosin contractility such that its loss in hepatocytes raises traction forces and tissue stiffness, activating YAP-driven proliferation through ROCK-dependent mechanotransduction (PMID:30878582). This length-control function underlies its roles in specialized actin-based structures, including cochlear hair-cell stereocilia, where CAPZB concentrates at tips in a mechanotransduction-dependent manner together with TWF2 and is required to maintain stereocilia length and width (PMID:28899994, PMID:31902726). CAPZB also acts beyond bulk actin regulation: it controls mitotic spindle orientation by regulating dynein/dynactin assembly and motor activity at the cell cortex and governs planar divisions in the developing neuroepithelium (PMID:28803871), and it is recruited by ALIX to multivesicular bodies to prevent branched F-actin accumulation, enabling MVB trafficking and exosome secretion (PMID:40185104). CAPZB is required for neural crest migration and craniofacial morphogenesis, with a human balanced translocation disrupting the gene (PMID:26758871), and its activity is regulated post-translationally by HDAC8-mediated desuccinylation at K57/K95/K235, with muscle-specific isoforms generated by QK/PTB-controlled alternative splicing of exon 9 (PMID:42050207, PMID:23525800).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1995 High

    Established that human CAPZB is a functional F-actin capping subunit and pinpointed the C-terminal residues responsible for actin binding, defining the molecular basis of its activity.

    Evidence F-actin cosedimentation and site-directed mutagenesis of conserved leucines; chromosomal mapping to 1p36.1

    PMID:7665558

    Open questions at the time
    • Did not address regulation of capping in cells
    • Heterodimer assembly with CAPZA not examined in this study
  2. 2009 Medium

    Showed that a tissue-specific CAPZ heterodimer organizes F-actin in a developmental context, extending CAPZB function to spermiation.

    Evidence ENU mutant mouse (repro32) with Capza3 missense mutation; CAPZB variant localization, F-actin staining, sperm morphology

    PMID:19341723

    Open questions at the time
    • Effect is via the CAPZA3 partner, not CAPZB itself
    • Single orthologous mouse model
  3. 2013 Medium

    Identified how muscle-specific CAPZB isoforms are generated, defining QK and PTB as antagonistic splicing regulators of exon 9.

    Evidence RNA affinity chromatography/MS, QK RNAi, RT-PCR splicing assays in myoblast differentiation

    PMID:23525800

    Open questions at the time
    • Functional consequence of the two isoforms on capping activity not resolved
    • Single lab
  4. 2013 Low

    Implicated CAPZB in regulated apical F-actin reorganization downstream of vasopressin, linking it to membrane trafficking.

    Evidence SILAC proteomics, surface biotinylation, vasopressin stimulation of collecting duct cells

    PMID:24085853

    Open questions at the time
    • No direct functional perturbation of CAPZB performed
    • Correlative proteomic association only
  5. 2016 Medium

    Revealed a moonlighting role for CAPZB in spindle orientation through regulation of cortical dynein/dynactin, distinct from its bulk actin function.

    Evidence RNAi in micropatterned Gαi-induction cells, spindle orientation imaging, dynein/dynactin analysis, in vivo neuroepithelium

    PMID:28803871

    Open questions at the time
    • Mechanism of dynein/dynactin regulation derived from single lab
    • Direct biochemical link to dynein/dynactin not established
  6. 2016 Medium

    Demonstrated organismal requirements for CAPZB in neural crest migration, differentiation, and craniofacial development, with human genetic support.

    Evidence Zebrafish capzb null and overexpression, neural crest imaging, in situ hybridization, human translocation case

    PMID:26758871

    Open questions at the time
    • Dosage sensitivity mechanism unresolved
    • Human evidence limited to a single translocation case
  7. 2016 Medium

    Linked CAPZB to tumor cell invasion and placed it within an INI1/SWI-SNF regulatory relationship in epithelioid sarcoma.

    Evidence siRNA knockdown, invasion/migration assays, iTRAQ proteomics, INI1 induction in EpiS cells

    PMID:26965049

    Open questions at the time
    • INI1-CAPZB regulation is correlative
    • Single lab and cell-line context
  8. 2016 Medium

    Showed that CAPZA-CAPZB heterodimer formation and capping function are controlled by TORC2-dependent phosphorylation, establishing regulated heterodimer assembly.

    Evidence Fission yeast genetics, Co-IP, phosphorylation analysis, live imaging of cytokinetic actomyosin ring

    PMID:27206859

    Open questions at the time
    • Demonstrated in yeast orthologs (Acp1/Acp2)
    • Conservation of TORC2 control in mammalian CAPZB not tested here
  9. 2017 High

    Quantified how CAPZB tunes mitotic cortex architecture and cortical tension, showing the cortex is poised near a tension maximum.

    Evidence RNAi knockdown, live imaging of cortex thickness, micropipette aspiration tension measurement, computational modeling

    PMID:28530659

    Open questions at the time
    • Does not separate CAPZB-specific from general capping effects
    • Downstream signaling consequences not examined
  10. 2017 High

    Defined CAPZB as essential for stereocilia dimension control and hearing/balance, showing capping prevents depolymerization of newly elongated filaments.

    Evidence Atoh1-Cre conditional KO, in utero electroporation overexpression, quantitative phalloidin imaging, ABR and vestibular assays

    PMID:28899994

    Open questions at the time
    • Molecular partners at stereocilia tips not yet defined in this study
    • Width-control mechanism inferred from morphology
  11. 2019 High

    Established CAPZB upstream of mechanotransduction-driven YAP activation, linking actin capping to tissue stiffness and organ growth.

    Evidence Capzb conditional KO mouse, traction force and atomic force microscopy, YAP assays, epistasis with ROCK inhibitor and Yap1 deletion

    PMID:30878582

    Open questions at the time
    • Direct molecular coupling between capping loss and YAP not fully mapped
    • Tissue-specificity beyond hepatocytes not tested
  12. 2020 Medium

    Showed that mechanotransduction activity itself specifies CAPZB subcellular localization at stereocilia row 2 tips, alongside TWF2.

    Evidence Cochlear hair cell immunofluorescence, Tmc1/Tmc2 and Tmie KO models, channel blocker, confocal imaging

    PMID:31902726

    Open questions at the time
    • Signal coupling transduction to CAPZB targeting unknown
    • Single lab
  13. 2025 Medium

    Identified ALIX as the recruiter of CAPZA1/CAPZB to MVBs, defining a capping-dependent mechanism enabling exosome secretion.

    Evidence Co-IP, PTPN23 KO and ALIX depletion, F-actin imaging around MVBs, exosome secretion assays in cancer cells

    PMID:40185104

    Open questions at the time
    • Structural basis of ALIX-CAPZ interaction not resolved
    • Single lab
  14. 2026 High

    Defined succinylation as a post-translational switch on CAPZB and HDAC8 as the desuccinylase, linking CAPZB regulation to fibroblast differentiation.

    Evidence MS site identification, K57/K95/K235 mutagenesis, gain/loss-of-function in fibroblasts and mouse model, HDAC8-CAPZB Co-IP, capping assays

    PMID:42050207

    Open questions at the time
    • Succinyl writer enzyme not identified
    • Generality across cell types beyond fibroblasts not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CAPZB switches between bulk cortical capping, structure-specific localization (stereocilia tips, MVBs), and its non-canonical dynein/dynactin role remains unresolved at the mechanistic level.
  • No structural model of mammalian CAPZA-CAPZB heterodimer in the corpus
  • Recruitment logic to distinct subcellular sites not unified
  • Direct biochemical mechanism of dynein/dynactin regulation undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 4 GO:0098772 molecular function regulator activity 4
Localization
GO:0005856 cytoskeleton 3 GO:0005886 plasma membrane 3 GO:0005768 endosome 1
Pathway
R-HSA-1266738 Developmental Biology 2 R-HSA-1640170 Cell Cycle 2 R-HSA-162582 Signal Transduction 1 R-HSA-5653656 Vesicle-mediated transport 1
Partners
ALIXCAPZA1CAPZA3HDAC8TWF2
Complex memberships
CapZ (F-actin capping protein heterodimer)

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 Human CAPZB (β subunit of Cap Z) binds F-actin via its C-terminal domain; cosedimentation assays showed binding affinity equal to chicken Cap Z. Amino acid substitutions of two conserved leucines in the C-terminal actin-binding domain of the chicken β subunit resulted in significant decreases in F-actin binding activity, identifying these residues as critical for actin binding. The human CAPZB gene was mapped to chromosome 1p36.1. F-actin cosedimentation assay; site-directed mutagenesis of conserved leucine residues; chromosomal mapping The Journal of biological chemistry High 7665558
2017 CAPZB regulates actin filament length at the mitotic cortex. Loss-of-function of CAPZB (along with CFL1 and DIAPH1) altered mitotic cortex thickness, and both increasing and decreasing thickness decreased cortical tension, indicating the mitotic cortex is poised near a tension maximum. CAPZB knockdown thus modulates cell surface tension through control of cortical actin network architecture. RNAi knockdown with live-cell imaging of cortex thickness; cortical tension measurements (micropipette aspiration); computational modeling Nature cell biology High 28530659
2019 CAPZB (CAPZ) restrains actomyosin contractility by capping actin barbed ends: Capzb conditional knockout in mouse hepatocytes led to altered stress fiber and focal adhesion dynamics, enhanced myosin activity, increased traction forces, and increased liver stiffness. This mechanical change activated YAP in parallel to the Hippo pathway, causing hepatocyte proliferation and liver overgrowth. ROCK inhibition or Yap1 deletion reversed these phenotypes, placing CAPZB upstream of mechanotransduction-driven YAP activation. Conditional knockout mouse (Capzb flox); traction force microscopy; atomic force microscopy (liver stiffness); YAP localization/activity assays; genetic epistasis with ROCK inhibitor (fasudil) and Yap1 deletion Journal of hepatology High 30878582
2017 CAPZB is required for stereocilia length and width regulation in cochlear hair cells. CAPZB is present at ~100 copies per stereocilium and concentrates at stereocilia tips as development progresses. Hair-cell-specific Capzb deletion (Atoh1-Cre) eliminated auditory and vestibular function; Capzb-null stereocilia initially developed normally but then shortened and disappeared, with concomitant decrease in width. Overexpression of CAPZB2 prevented normal elongation and caused irregular widening, indicating capping protein participates in stereocilia widening by preventing newly elongating actin filaments from depolymerizing. Hair-cell-specific conditional knockout (Atoh1-Cre); in utero electroporation overexpression; phalloidin labeling with quantitative imaging of stereocilia dimensions; auditory brainstem response and vestibular assays The Journal of cell biology High 28899994
2016 CAPZB controls spindle orientation independently of its classical role in actin cytoskeleton. RNAi depletion of CAPZB in a micropatterning/Gαi-induction cell model disrupted spindle orientation. Mechanistically, CAPZB regulates the assembly, stability, and motor activity of the dynein/dynactin complex at the cell cortex and controls mitotic microtubule dynamics. In vivo, CAPZB controls planar divisions in the developing neuroepithelium. RNAi screen in micropatterned cells with localized Gαi recruitment; live imaging of spindle orientation; dynein/dynactin complex analysis; in vivo neuroepithelium assay Current biology : CB Medium 28803871
2016 CAPZB regulates cell morphology, differentiation, and neural crest migration in craniofacial morphogenesis. In zebrafish capzb−/− mutants, loss of capzb disrupted neural crest cell migration, caused cleft phenotype by loss of the median cell population, and disrupted trunk neural crest migration (melanophore disorganization). capzb was required for differentiation of both myogenic stem cells and neural crest cells. capzb overexpression caused embryonic lethality, indicating dosage sensitivity. Zebrafish capzb null mutant and overexpression; live imaging of neural crest migration; whole-mount in situ hybridization; human case with de novo balanced chromosomal translocation disrupting CAPZB Human molecular genetics Medium 26758871
2016 In fission yeast, TORC2-dependent phosphorylation of the actin-capping protein Acp1 (equivalent of mammalian CAPZα) controls cytokinetic actomyosin ring (CAR) stability and modulates Acp1-Acp2 (CAPZA-CAPZB) heterodimer formation; disruption of TORC2 or this phosphorylation impairs CAR morphology and constriction. Fission yeast genetics; co-immunoprecipitation; phosphorylation analysis; live-cell imaging of CAR dynamics Journal of cell science Medium 27206859
2016 CAPZB knockdown in epithelioid sarcoma cells inhibited cell growth, invasion, and migration. Proteomic profiling after CAPZB silencing identified INI1 (SWI/SNF complex) as a potential upstream regulator of CAPZB; silencing CAPZB decreased INI1 protein expression in INI1-positive cells, while INI1 induction in INI1-deficient cells increased CAPZB mRNA. siRNA knockdown in EpiS cell lines; invasion/migration assays; iTRAQ quantitative proteomics; INI1 overexpression; IPA pathway analysis BMC cancer Medium 26965049
2009 A spermatid-specific CAPZ heterodimer (CAPZA3/CAPZB variant isoform) is essential for F-actin network organization during spermiation. In repro32 mice with a missense mutation in Capza3, CAPZB variant isoform localization was altered concurrent with disruption of the F-actin network, failure to shed excess cytoplasm, and disorganization of the sperm flagellum midpiece. This established that the CAPZA3/CAPZB heterodimer regulates F-actin dynamics required for cytoplasm removal and midpiece integrity. ENU-induced mutant mouse (repro32); candidate-gene sequencing; immunofluorescence localization of CAPZB variant; F-actin staining; sperm morphology and motility analysis Developmental biology Medium 19341723
2020 CAPZB localizes to stereocilia tips at row 2 of cochlear inner hair cells in a mechanotransduction-dependent manner. In transduction mutants (Tmc1/Tmc2 or Tmie knockouts), CAPZB and its partner TWF2 failed to concentrate at row 2 tips. Block of transduction channels also redistributed CAPZB from row 2 tips, demonstrating that mechanotransduction activity specifies CAPZB subcellular localization at stereocilia. Mouse cochlear hair cell immunofluorescence; Tmc1/Tmc2 and Tmie knockout models; transduction channel blocker treatment; quantitative confocal imaging Current biology : CB Medium 31902726
2013 Vasopressin treatment of kidney collecting duct cells caused significant changes in abundance of CAPZB at the apical plasma membrane. CAPZB was identified as one of five F-actin end-binding proteins involved in vasopressin-induced F-actin reorganization, which is required for aquaporin-2 apical trafficking and increased water permeability. Stable isotope quantitative proteomics (SILAC); surface biotinylation; live-cell F-actin imaging; vasopressin stimulation of mouse cortical collecting duct cells Proceedings of the National Academy of Sciences of the United States of America Low 24085853
2013 Quaking (QK) promotes inclusion of Capzb exon 9 in opposition to repression by polypyrimidine tract-binding protein (PTB) during muscle cell differentiation. Mass spectrometry of proteins selected by the Capzb exon 9 intron (containing ACUAA STAR motifs) via RNA affinity chromatography identified QK as a splicing regulator of this exon, establishing a mechanism for muscle-specific alternative splicing of CAPZB. RNA affinity chromatography with mass spectrometry; QK depletion by RNAi; RT-PCR splicing assays; myoblast-to-myotube differentiation model RNA (New York, N.Y.) Medium 23525800
2025 ALIX recruits actin-capping proteins CAPZA1/CAPZB to prevent branched filamentous actin (F-actin) accumulation around multivesicular bodies (MVBs), enabling MVB trafficking to the cell periphery for exosome secretion. PTPN23 (competitor of ALIX for syntenin binding) does not recruit CAPZA1/CAPZB. This ALIX–CAPZA1/CAPZB mechanism is required for the pro-tumorigenic exosome secretion pathway. Co-immunoprecipitation; genetic perturbation (PTPN23 knockout, ALIX depletion); F-actin visualization around MVBs; exosome secretion assays in mouse and human cancer cells Developmental cell Medium 40185104
2026 HDAC8 desuccinylates CAPZB at lysine residues K57, K95, and K235. CAPZB regulates cytoskeletal remodeling and fibroblast-to-myofibroblast differentiation by capping the barbed end of F-actin. Desuccinylation (removal of succinyl groups) inhibits CAPZB function and promotes cytoskeletal remodeling; mutation of the modification sites confirmed that succinylation inhibits CAPZB activity. HDAC8 physically interacts with CAPZB and its pro-fibrotic role as a desuccinylase was verified in vitro and in vivo. Mass spectrometry identification of succinylation sites; site-directed mutagenesis of K57/K95/K235; gain- and loss-of-function in fibroblasts and in vivo mouse model; Co-IP of HDAC8 with CAPZB; F-actin capping and cytoskeletal assays Communications biology High 42050207

Source papers

Stage 0 corpus · 73 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 Actin cortex architecture regulates cell surface tension. Nature cell biology 313 28530659
2013 Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiation. RNA (New York, N.Y.) 133 23525800
2023 Pan-cancer genetic analysis of disulfidptosis-related gene set. Cancer genetics 127 37879141
2019 F-actin dynamics regulates mammalian organ growth and cell fate maintenance. Journal of hepatology 71 30878582
2017 Whole genome scan reveals the genetic signature of African Ankole cattle breed and potential for higher quality beef. BMC genetics 67 28183280
2020 Mechanotransduction-Dependent Control of Stereocilia Dimensions and Row Identity in Inner Hair Cells. Current biology : CB 60 31902726
2013 Quantitative apical membrane proteomics reveals vasopressin-induced actin dynamics in collecting duct cells. Proceedings of the National Academy of Sciences of the United States of America 60 24085853
2009 A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice. Developmental biology 56 19341723
1995 Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. The Journal of biological chemistry 54 7665558
2012 Identification of differentially expressed proteins between bull X and Y spermatozoa. Journal of proteomics 51 22820535
2019 A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection. mBio 45 31594818
2017 Heterodimeric capping protein is required for stereocilia length and width regulation. The Journal of cell biology 45 28899994
2011 Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. American journal of human genetics 43 21565293
2010 A locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study. American journal of human genetics 42 20826269
2009 Porcine muscle sensory attributes associate with major changes in gene networks involving CAPZB, ANKRD1, and CTBP2. Functional & integrative genomics 39 19597856
2018 Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus. Viruses 38 29702546
2020 Label free shotgun proteomics for the identification of protein biomarkers for beef tenderness in muscle and plasma of heifers. Journal of proteomics 35 32058039
2016 Actin capping protein CAPZB regulates cell morphology, differentiation, and neural crest migration in craniofacial morphogenesis†. Human molecular genetics 35 26758871
2021 Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD 34 33252074
2012 Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function. Human molecular genetics 33 22494929
2018 Characterization of the effects of trace concentrations of graphene oxide on zebrafish larvae through proteomic and standard methods. Ecotoxicology and environmental safety 30 29753824
2017 Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90. PloS one 29 28056051
2014 2D-DIGE proteome analysis on the platelet proteins of patients with major depression. Proteome science 27 24383611
2018 Proteomic pattern of implantative human endometrial fluid in in vitro fertilization cycles. Archives of gynecology and obstetrics 26 29637268
2011 Reduction in antioxidant enzyme expression and sustained inflammation enhance tissue damage in the subacute phase of spinal cord contusive injury. Journal of biomedical science 26 21299884
2023 Non-allergic eye rubbing is a major behavioral risk factor for keratoconus. PloS one 25 37053215
2014 Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations. Human molecular genetics 25 24852370
2021 Bull Sperm Capacitation Is Accompanied by Redox Modifications of Proteins. International journal of molecular sciences 24 34360666
2021 ViaFuse: Fiji macros to calculate skeletal muscle cell viability and fusion index. Skeletal muscle 23 34915930
2015 Proteomic analysis reveals that the protective effects of ginsenoside Rb1 are associated with the actin cytoskeleton in β-amyloid-treated neuronal cells. Journal of ginseng research 23 27616904
2021 Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 21 34004362
2018 Pretreatment with cholesterol-loaded cyclodextrins prevents loss of motility associated proteins during cryopreservation of addra gazelle (Nanger dama ruficollis) spermatozoa. Cryobiology 21 29458042
2016 Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma. Oncotarget 19 27391153
2020 The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies? FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18 32619075
2016 TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis. Journal of cell science 18 27206859
2018 Expression pattern of prohibitin, capping actin protein of muscle Z-line beta subunit and tektin-2 gene in Murrah buffalo sperm and its relationship with sperm motility. Asian-Australasian journal of animal sciences 15 29642674
2016 Expression of F-actin-capping protein subunit beta, CAPZB, is associated with cell growth and motility in epithelioid sarcoma. BMC cancer 15 26965049
2017 An RNAi Screen in a Novel Model of Oriented Divisions Identifies the Actin-Capping Protein Z β as an Essential Regulator of Spindle Orientation. Current biology : CB 13 28803871
1997 Fine mapping of 39 ESTs on human chromosome 6p23-p25. Genomics 12 9417921
2023 Genome-Wide Analysis of Sheep Artificially or Naturally Infected with Gastrointestinal Nematodes. Genes 11 37510248
2021 Effect of 2-Cys Peroxiredoxins Inhibition on Redox Modifications of Bull Sperm Proteins. International journal of molecular sciences 11 34884692
2017 Differential expression pattern of protein markers for predicting chemosensitivity of dexamethasone-based chemotherapy of B cell acute lymphoblastic leukemia. Cancer chemotherapy and pharmacology 11 28585036
2021 Proteomic Analysis Identifies Potential Markers for Chicken Primary Follicle Development. Animals : an open access journal from MDPI 9 33924300
2012 Actin capping proteins, CapZ (β-actinin) and tropomodulin in amphioxus striated muscle. Gene 9 22951807
2024 Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract. Frontiers in ophthalmology 8 38984127
2015 Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients. International journal of endocrinology 8 26273293
2020 Genome-wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma. Oncology letters 7 33133257
2024 Effect of cholesterol-loaded cyclodextrin treatment on boar sperm cryopreservation. Animal bioscience 6 38754842
2020 A new 1p36.13-1p36.12 microdeletion syndrome characterized by learning disability, behavioral abnormalities, and ptosis. Clinical genetics 6 32170730
2017 Genetic analysis of VCP and WASH complex genes in a German cohort of sporadic ALS-FTD patients. Neurobiology of aging 6 28551275
2017 Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS). Pharmacogenetics and genomics 6 28727628
2025 Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies. Developmental cell 5 40185104
2024 New insights into the hypothalamic-pituitary-thyroid axis: a transcriptome- and proteome-wide association study. European thyroid journal 5 38805593
2014 Identification and characterization of a differentially expressed protein (CAPZB) in skeletal muscle between Meishan and Large White pigs. Gene 5 24792893
2008 Investigation of eight candidate genes on chromosome 1p36 for autosomal dominant total congenital cataract. Molecular vision 5 18843385
2024 Novel insights of disulfidptosis-mediated immune microenvironment regulation in atherosclerosis based on bioinformatics analyses. Scientific reports 4 39521794
2025 Exploring a novel risk model based on core disulfidptosis-related genes in periodontitis: Bioinformatics analyses and experimental validation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 3 39924928
2025 Proteomic insights into lymph node metastasis in breast cancer subtypes: Key biomarkers and pathways. Pathology, research and practice 3 40179440
2024 CAPZB mRNA is a novel biomarker for cervical high-grade squamous lesions. Scientific reports 3 39209986
2024 Identification and validation of differentially expressed disulfidptosis-related genes in hypertrophic cardiomyopathy. Molecular medicine (Cambridge, Mass.) 3 39701955
2018 Subclinical thyroid disease and single nucleotide polymorphisms in reproductive-age women in areas of Shanxi Province, China, where iodine exposure is excessive. Asia Pacific journal of clinical nutrition 3 30485936
2024 Activation of AMPK in platelets promotes the production of offspring. Platelets 2 38630016
2024 Disulfidptosis and Its Hub Gene Slc3a2 Involved in Ulcerative Colitis Pathogenesis, Disease Progression, and Patient Responses to Biologic Therapies. International journal of molecular sciences 2 39769269
2022 Transcriptome-wide association study identifies multiple genes and pathways associated with thyroid function. Human molecular genetics 2 34962261
2025 Genetic Variants Related to TGF-β Signaling Pathway Modulate Risk of Meniscus Injury: A Multiancestry Genome-wide Association Study. Clinical orthopaedics and related research 1 40971882
2026 Identification of a novel real-time PCR reference gene panel for EA.hy926 endothelial cells in different growth States and with DHA treatment. Scientific reports 0 41559137
2026 Epitranscriptomic signatures of m5C, m6A, and pseudouridine in COVID-19 reveal host RNA modifications involved in viral pathogenesis. Microbiology spectrum 0 41586584
2026 HDAC8-mediated CAPZB desuccinylation enhances cytoskeleton remodeling to promote idiopathic pulmonary fibrosis. Communications biology 0 42050207
2025 Genome-wide DNA methylation and transcriptome sequencing analyses of lens tissue in an age-related mouse cataract model. PloS one 0 39883715
2025 Transcriptome profiling and alternative splicing analysis of skeletal muscle in Pseudocaranx dentex: insights into slow-twitch and fast-twitch muscle specialization. International journal of biological macromolecules 0 40360119
2025 Stage-Specific Serum Proteomic Signatures Reveal Early Biomarkers and Molecular Pathways in Huntington's Disease Progression. Cells 0 40801627
2025 Polymorphism as Biomarker Analysis of Genes TSHR, DIO1, FOXE1, and CAPZB in Hypothyroidism Patients. Endocrine research 0 40963443
2025 Exploring Genetic Markers for Cold-Heat Patterns: Integrating Traditional Medicine With Modern Genomic Research. Genetics research 0 41322252

Missed literature

Know a paper Affinage missed for CAPZB? Flag it for the maintainers and the community.

No submissions yet.