{"gene":"CLTC","run_date":"2026-06-09T22:57:18","timeline":{"discoveries":[],"current_model":"Parse failed"},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q00610","full_name":"Clathrin heavy chain 1","aliases":["Clathrin heavy chain on chromosome 17","CLH-17"],"length_aa":1675,"mass_kda":191.6,"function":"Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity)","subcellular_location":"Cytoplasmic vesicle membrane; Membrane, coated pit; Melanosome; Cytoplasm, cytoskeleton, spindle","url":"https://www.uniprot.org/uniprotkb/Q00610/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":true,"resolved_as":"","url":"https://depmap.org/portal/gene/CLTC","classification":"Common 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MRD56","url":"https://www.omim.org/entry/617854"},{"mim_id":"616945","title":"CLAVESIN 2; CLVS2","url":"https://www.omim.org/entry/616945"},{"mim_id":"616916","title":"SMALL ADP-RIBOSYLATION FACTOR GTPase-ACTIVATING PROTEIN 2; SMAP2","url":"https://www.omim.org/entry/616916"},{"mim_id":"615879","title":"TATTON-BROWN-RAHMAN SYNDROME; TBRS","url":"https://www.omim.org/entry/615879"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Enhanced","locations":[{"location":"Endosomes","reliability":"Enhanced"},{"location":"Lysosomes","reliability":"Enhanced"},{"location":"Mitotic spindle","reliability":"Additional"},{"location":"Centriolar satellite","reliability":"Additional"},{"location":"Cytosol","reliability":"Additional"},{"location":"Mid piece","reliability":"Additional"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/CLTC"},"hgnc":{"alias_symbol":["Hc"],"prev_symbol":["CLTCL2"]},"alphafold":{"accession":"Q00610","domains":[{"cath_id":"2.130.10.10","chopping":"16-144","consensus_level":"medium","plddt":88.8212,"start":16,"end":144},{"cath_id":"2.130.10.110","chopping":"145-330","consensus_level":"medium","plddt":89.283,"start":145,"end":330},{"cath_id":"1.25.40.10","chopping":"1078-1165","consensus_level":"medium","plddt":68.4223,"start":1078,"end":1165},{"cath_id":"-","chopping":"1535-1612","consensus_level":"medium","plddt":74.5,"start":1535,"end":1612}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q00610","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q00610-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q00610-F1-predicted_aligned_error_v6.png","plddt_mean":75.44},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=CLTC","jax_strain_url":"https://www.jax.org/strain/search?query=CLTC"},"sequence":{"accession":"Q00610","fasta_url":"https://rest.uniprot.org/uniprotkb/Q00610.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q00610/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q00610"}},"corpus_meta":[{"pmid":"2841611","id":"PMC_2841611","title":"Thyroid 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pathways.","date":"2021","source":"Clinical and translational medicine","url":"https://pubmed.ncbi.nlm.nih.gov/34185412","citation_count":12,"is_preprint":false},{"pmid":"38530741","id":"PMC_38530741","title":"Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator.","date":"2024","source":"Journal of medicinal chemistry","url":"https://pubmed.ncbi.nlm.nih.gov/38530741","citation_count":12,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":51539,"output_tokens":91,"usd":0.077991,"stage1_stop_reason":"refusal"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.077991,"stage1_batch_id":"msgbatch_01ACAxJQabDsht39JXeWG22d","stage2_batch_id":"msgbatch_01QEU22A9U5sbPTgsMzTmvSf","note":"batch pricing = 50% of standard"},"stage1_raw":"Looking through the abstracts, I need to identify papers about CLTC (Clathrin Heavy Chain 1, the canonical human gene at 17q23). Many papers in this corpus are about completely different genes/topics (HC-Pro plant viral proteins, protein HC/","stage2_raw":"","audit_flag":{"gene":"CLTC","tier":"GROUNDING","verdict":"Evidence-grounding concern","subtype":"recall_miss","uniprot_band":"medium","rules_fired":"R5","issue":"R5: no narrative despite experimental UniProt FUNCTION (787 chars) and on-target evidence in corpus (16 on-target corpus titles)"},"evaluation":null}