Affinage

HNRNPA2B1

Heterogeneous nuclear ribonucleoproteins A2/B1 · UniProt P22626

Length
353 aa
Mass
37.4 kDa
Annotated
2026-06-10
100 papers in source corpus 42 papers cited in narrative 42 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

HNRNPA2B1 is a multifunctional, modification-regulated RNA-binding protein that couples RNA metabolism to gene expression, genome maintenance, innate immunity, and proteostasis (PMID:26321680, PMID:27773581). In the nucleus it acts as a reader of N6-methyladenosine, binding m6A-marked transcripts through its RRM domains to direct alternative splicing, promote Microprocessor-dependent primary miRNA processing via interaction with DGCR8, and mediate nuclear export of m6A-tagged mRNAs through the ALYREF/NXF1 pathway (PMID:26321680, PMID:38626369). Genome-wide it binds UAGG-containing sites in thousands of transcripts and governs alternative splicing and polyadenylation, including disease-relevant targets in motor neurons (PMID:27773581). Its intrinsically disordered low-complexity (prion-like) domain drives liquid–liquid phase separation and assembly of stress-granule-associated, amyloid-like cross-β polymers; pathogenic mutations in this domain (e.g., D290V, P298L) strengthen a steric zipper, stabilize self-seeding fibrils, and drive cytoplasmic inclusion formation, while RNA binding and arginine methylation oppose phase separation (PMID:23455423, PMID:29358076, PMID:32796831, PMID:32870271). Heterozygous PrLD missense mutations and reading-frame-extending frameshift variants that impair karyopherin-β2 binding cause multisystem proteinopathy and early-onset oculopharyngeal muscular dystrophy, respectively (PMID:23455423, PMID:35484142). HNRNPA2B1 stabilizes stress granules by maintaining the G3BP1–USP10/Caprin-1 interaction, and Hnrnpa2b1 loss in mice causes Sertoli-cell-only syndrome and male infertility (PMID:38363675). It functions as a nucleic-acid and metabolite sensor in innate immunity: it senses viral DNA, homodimerizes, and after JMJD6-mediated arginine demethylation translocates to the cytoplasm to activate TBK1-IRF3 and type I IFN production, and it senses nuclear adenine to remodel Il1b enhancer chromatin via nucleolin and FTO (PMID:31320558, PMID:39814017). Its activity is tuned by an extensive set of post-translational modifications—sumoylation, arginine methylation, tyrosine phosphorylation by Fyn, acetylation by p300, ISGylation, and ubiquitination by TRIM21—that control its localization, stability, phase behavior, and substrate selection (PMID:24356509, PMID:31320558, PMID:33349959, PMID:36702126, PMID:38626369, PMID:37716979). SUMOylated HNRNPA2B1 additionally restrains RPA accumulation at replication forks to limit ATR activation and homologous recombination repair (PMID:36702126).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2010 Medium

    Established that HNRNPA2 acts beyond RNA metabolism as a stress-responsive transcriptional coactivator, linking mitochondrial stress signaling to nuclear gene transcription.

    Evidence In vivo phosphorylation assays and ChIP at stress target promoters with dominant-negative constructs under mitochondrial respiratory stress

    PMID:20153290

    Open questions at the time
    • Direct vs. indirect promoter binding not structurally resolved
    • Generality beyond the specific stress promoters tested unclear
  2. 2013 High

    Defined the prion-like domain as the structural basis of disease, showing PrLD mutations strengthen a steric zipper to drive self-seeding fibrils and cytoplasmic inclusions.

    Evidence Fibril assembly and seeding assays, stress granule imaging in cells and animal models, mutagenesis

    PMID:23455423

    Open questions at the time
    • Atomic fibril architecture not yet resolved at this stage
    • In vivo trigger of pathological transition not defined
  3. 2013 High

    Identified HNRNPA2B1 as the RNA-binding protein controlling sequence-specific loading of miRNAs into exosomes, regulated by sumoylation.

    Evidence RNA immunoprecipitation, sumoylation assays, and EXO-motif mutagenesis with exosomal miRNA readout

    PMID:24356509

    Open questions at the time
    • SUMO site and machinery not fully mapped
    • Mechanism coupling sumoylation to RNA affinity unresolved
  4. 2015 High

    Established HNRNPA2B1 as a nuclear m6A reader that couples the mark to alternative splicing and Microprocessor-dependent pri-miRNA processing via DGCR8.

    Evidence In vitro and in vivo RIP, splicing assays, METTL3/HNRNPA2B1 knockdown epistasis, and Co-IP with DGCR8

    PMID:26321680

    Open questions at the time
    • Direct m6A contact vs. structural remodeling debated
    • Selectivity rules for which m6A transcripts are read not defined
  5. 2015 High

    Showed the LC domain adopts the same cross-β polymeric conformation in hydrogels, droplets, and native nuclei, arguing for a physiological role of LC polymerization.

    Evidence Molecular footprinting of LC polymeric state, hydrogel preparation, EM, and analysis of isolated nuclei

    PMID:26544936

    Open questions at the time
    • Functional readout of nuclear polymerization not directly measured
    • Reversibility in vivo not quantified
  6. 2016 High

    Mapped transcriptome-wide binding (UAGG motifs) and a role in alternative polyadenylation and splicing, connecting loss of function and the D290V mutant to ALS-relevant mis-splicing.

    Evidence CLIP-seq in mouse spinal cord, RNA-seq upon knockdown, and patient fibroblast/iPSC-motor neuron analysis

    PMID:27773581

    Open questions at the time
    • Causal contribution of individual splicing targets to disease unproven
    • Mechanism linking insolubility to splicing defects unclear
  7. 2018 High

    Provided structural insight into LC-domain disorder and phase separation, and showed arginine methylation suppresses phase separation while disease mutations enhance aggregation.

    Evidence NMR spectroscopy, in vitro phase separation and arginine methylation assays, mutagenesis

    PMID:29358076 PMID:30279180

    Open questions at the time
    • Endogenous methylation stoichiometry not measured
    • Cross-seeding of TDP-43 in vivo not established
  8. 2018 High

    Demonstrated regulation of phase behavior by Fyn-SH3 binding to the LC domain, defining a kinase–client interface controlling granule assembly.

    Evidence Solution NMR and in vitro phase separation microscopy

    PMID:30397184

    Open questions at the time
    • Cellular consequence of Fyn-SH3 recruitment not measured here
    • Stoichiometry in physiological granules unknown
  9. 2019 High

    Revealed HNRNPA2B1 as a nuclear viral-DNA sensor that, after JMJD6-mediated arginine demethylation, translocates to the cytoplasm to drive TBK1-IRF3 type I IFN signaling.

    Evidence Co-IP, JMJD6 demethylation assays, nuclear-cytoplasmic fractionation, TBK1-IRF3 activation, and m6A RIP on CGAS/IFI16/STING mRNAs

    PMID:31320558

    Open questions at the time
    • Direct DNA-binding mode not structurally resolved
    • How demethylation triggers nuclear export mechanistically unclear
  10. 2020 High

    Resolved wild-type vs. D290V fibril architecture at atomic resolution, explaining how the mutation thermodynamically stabilizes pathogenic polymers.

    Evidence CryoEM of the LCD fibril core, crystal structure of the D290V segment, and energetic calculations

    PMID:32796831

    Open questions at the time
    • Relationship between in vitro fibril and in vivo inclusion structure not established
    • Therapeutic targetability of the zipper untested
  11. 2020 High

    Showed RRM-bound A2RE RNA suppresses phase separation and aggregation, establishing RNA as a built-in regulator of HNRNPA2B1 condensation.

    Evidence Solution NMR of RRM–RNA interaction and in vitro phase separation assays with RNA addition

    PMID:32870271

    Open questions at the time
    • RNA concentrations relevant in vivo not defined
    • Whether endogenous RNAs protect cells from aggregation untested
  12. 2020 High

    Demonstrated Fyn tyrosine phosphorylation reduces phase separation and disease-variant aggregation and rescues neurodegeneration in vivo.

    Evidence In vitro tyrosine phosphorylation and phase separation assays plus C. elegans Fyn-expression rescue

    PMID:33349959

    Open questions at the time
    • Mammalian in vivo phosphorylation dynamics not measured
    • Phosphosite occupancy under stress unknown
  13. 2023 High

    Identified a non-canonical genome-protective role: SUMOylated HNRNPA2B1 sequesters RPA via its SIM to limit fork RPA loading and ATR activation, tuning DNA repair.

    Evidence Co-IP defining SUMO-SIM interaction, chromatin fractionation, ATR activation, HR assays, and PARP inhibitor sensitivity

    PMID:36702126

    Open questions at the time
    • SUMO E3 ligase responsible not identified
    • Crosstalk with HNRNPA2B1's RNA functions during replication stress unclear
  14. 2024 High

    Defined HNRNPA2B1 as a repressor of stress-granule disassembly through the G3BP1-USP10/Caprin-1 axis and as essential for spermatogenesis in vivo.

    Evidence Co-IP, ubiquitination and proteasome/autophagy inhibitor assays, and Hnrnpa2b1 KO mouse fertility phenotyping

    PMID:38363675

    Open questions at the time
    • Direct vs. scaffold role in the G3BP1 complex unresolved
    • Link between SG regulation and the infertility phenotype not established
  15. 2024 Medium

    Linked ISGylation to control of HNRNPA2B1 stability and selective m6A-mRNA nuclear export via ALYREF/NXF1.

    Evidence Co-IP of PCAT6-ISG15-HNRNPA2B1 and HNRNPA2B1-ALYREF/NXF1, ISGylation and ubiquitination assays, and mRNA export assays

    PMID:38626369

    Open questions at the time
    • ISGylation site not mapped
    • Competition between ISGylation and ubiquitination not quantified
  16. 2025 High

    Extended HNRNPA2B1's sensor function to a small metabolite, showing nuclear adenine binding activates it to remodel Il1b enhancer chromatin and drive IL-1β during bacterial infection.

    Evidence Metabolite-protein interaction screen, direct adenine binding, ChIP and chromatin accessibility at Il1b enhancers, Co-IP with nucleolin/FTO, and myeloid cKO mice

    PMID:39814017

    Open questions at the time
    • Adenine-binding pocket structure not resolved
    • Generality to other metabolites and enhancers untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How HNRNPA2B1's many post-translational modifications are integrated to switch it between its nuclear RNA-processing, condensate, genome-protective, and cytoplasmic immune-sensing states remains unresolved.
  • No unified model coordinating SUMO/methyl/phospho/acetyl/ISG/ubiquitin marks
  • Quantitative partitioning between competing functions in a single cell unknown
  • Structural basis for RRM-mediated nucleic-acid and metabolite sensing incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 8 GO:0003677 DNA binding 3 GO:0140098 catalytic activity, acting on RNA 3 GO:0140110 transcription regulator activity 3 GO:0060090 molecular adaptor activity 2 GO:0140299 molecular sensor activity 2 GO:0140096 catalytic activity, acting on a protein 1
Localization
GO:0005634 nucleus 5 GO:0005829 cytosol 4 GO:0031410 cytoplasmic vesicle 3 GO:0005730 nucleolus 1
Pathway
R-HSA-8953854 Metabolism of RNA 4 R-HSA-168256 Immune System 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-8953897 Cellular responses to stimuli 2 R-HSA-9609507 Protein localization 2 R-HSA-73894 DNA Repair 1
Partners
CAPRIN-1DGCR8FYNG3BP1JMJD6PABPC1TRIM21USP10
Complex memberships
ALYREF/NXF1 mRNA export complexMicroprocessor (with DGCR8)stress granule (G3BP1/USP10/Caprin-1)

Evidence

Reading pass · 42 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 hnRNPA2B1 specifically binds exosomal miRNAs through recognition of specific sequence motifs (EXO motifs), controlling their loading into exosomes. In exosomes, hnRNPA2B1 is sumoylated, and sumoylation controls its binding to miRNAs. Mutagenesis of identified motifs or changes in hnRNPA2B1 expression levels modulate miRNA loading into exosomes. RNA immunoprecipitation, sumoylation assays, mutagenesis of miRNA motifs, modulation of hnRNPA2B1 expression Nature communications High 24356509
2015 HNRNPA2B1 binds m6A-bearing RNAs in vivo and in vitro with a biochemical footprint matching the m6A consensus motif, acting as a nuclear reader of the m6A mark. It mediates alternative splicing of nuclear transcripts similarly to the m6A writer METTL3, binds m6A marks in primary miRNA transcripts, interacts with the Microprocessor complex protein DGCR8, and promotes primary miRNA processing. RNA immunoprecipitation (in vivo and in vitro), alternative splicing assays, HNRNPA2B1 and METTL3 knockdown with pri-miRNA processing readout, Co-IP with DGCR8 Cell High 26321680
2013 Pathogenic missense mutations in the prion-like domain (PrLD) of hnRNPA2B1 (e.g., D290V) strengthen a steric zipper motif, exacerbating formation of self-seeding fibrils that cross-seed wild-type hnRNP polymerization. Wild-type hnRNPA2 shows intrinsic tendency to assemble into self-seeding fibrils. Disease mutations promote excess incorporation into stress granules and drive cytoplasmic inclusion formation in animal models. Fibril assembly assays, seeding experiments, stress granule imaging in cells and animal models, mutagenesis Nature High 23455423
2018 The hnRNPA2 low-complexity (LC) domain is compact and intrinsically disordered as a monomer and retains predominant disorder in a liquid-liquid phase-separated form. Disease mutations D290V and P298L induce aggregation by enhancing and extending the aggregation-prone region respectively. The hnRNPA2 LC domain directly interacts with and induces phase separation of TDP-43. Arginine methylation reduces hnRNPA2 phase separation by disrupting arginine-mediated contacts. NMR spectroscopy, in vitro phase separation assays, mutagenesis, arginine methylation assays Molecular cell High 29358076
2019 Upon DNA virus infection, nuclear hnRNPA2B1 senses viral DNA, homodimerizes, and is then demethylated at arginine-226 by the arginine demethylase JMJD6. This leads to hnRNPA2B1 translocation to the cytoplasm where it activates the TBK1-IRF3 pathway, inducing IFN-α/β production. Additionally, hnRNPA2B1 facilitates m6A modification and nucleocytoplasmic trafficking of CGAS, IFI16, and STING mRNAs to amplify cytoplasmic antiviral signaling. Co-IP, demethylation assays identifying JMJD6 as writer/eraser, nuclear-cytoplasmic fractionation, TBK1-IRF3 pathway activation assays, m6A RIP on CGAS/IFI16/STING mRNAs Science (New York, N.Y.) High 31320558
2015 The LC domain of hnRNPA2 adopts a similar conformation in hydrogel polymers, liquid-like droplets, and isolated nuclei, forming amyloid-like cross-β fibers. A molecular footprinting technique applied to native hnRNPA2 in isolated nuclei showed its LC domain exists in a similar polymeric conformation to recombinant polymers, suggesting biologic utility for LC domain polymerization in information transfer. Molecular footprinting of polymeric LC domain state, hydrogel polymer preparation, electron microscopy, analysis of isolated nuclei Cell High 26544936
2016 Transcriptome-wide CLIP in mouse spinal cord identified UAGG motifs enriched within ~2,500 hnRNP A2/B1 binding sites and revealed a role for hnRNP A2/B1 in alternative polyadenylation. hnRNP A2/B1 loss causes alternative splicing changes including skipping of an exon in ALS-associated D-amino acid oxidase (DAO) that reduces D-serine metabolism. ALS-associated D290V mutant shows increased nuclear-insoluble hnRNP A2/B1 and abnormal splicing in patient fibroblasts and iPSC-derived motor neurons. CLIP-seq in mouse spinal cord, RNA-seq upon KD, patient fibroblast and iPSC-MN analysis, nuclear fractionation Neuron High 27773581
2020 CryoEM structure of the hnRNPA2 LCD fibril core revealed chains kinked in a cross-β conformation enabling non-covalent cross-linking of fibrils, distinguishing them from pathogenic amyloid. The D290V disease mutation fundamentally alters fibril structure to a more stable energetic state, as shown by crystal structure of the D290V-containing segment forming a steric zipper. CryoEM structure determination, crystal structure of D290V segment, hydrogel formation assay, energetic calculations Nature communications High 32796831
2018 Solid-state NMR with segmental isotope labeling showed that both wild-type hnRNPA2 LC and the D290V mutant form labile polymers in an in-register cross-β conformation. Aspartic acid 290 is charged at physiological pH and immobilized within the polymer core; D290V mutation removes destabilizing electrostatic interactions, making polymers thermodynamically more stable. Solid-state NMR spectroscopy with segmental isotope labeling, electron microscopy, thermodynamic stability measurements Proceedings of the National Academy of Sciences of the United States of America High 30279180
2021 Optogenetically induced tau oligomers (oTau) associate with HNRNPA2B1 (identified by proteomics and validated in neurons, animal models, and human Alzheimer brain). HNRNPA2B1 functions as a linker connecting oTau with m6A-modified RNA transcripts. Knockdown of HNRNPA2B1 prevents oTau from associating with m6A or reducing protein synthesis and reduces oTau-induced neurodegeneration. Optogenetic tau oligomerization (Cry2-based), proteomics, Co-IP in neurons and animal models, HNRNPA2B1 knockdown with neurodegeneration readout, m6A association assay Molecular cell High 34453888
2014 HNRNPA2B1 (hnRNP A2 and B1 proteins encoded by HNRNPA2B1) interacts with oncogenic KRAS G12V in PDAC cells as shown by mass spectrometry and Co-IP. This interaction requires KRAS phosphorylation at serine 181. Knockdown of HNRNPA2B1 inactivates AKT-mTOR signaling, reduces interaction between KRAS and PI3K, and reduces KRAS-dependent PDAC cell survival and tumor formation. Mass spectrometry pulldown, Co-IP, Phos-tag phosphorylation analysis, shRNA knockdown, xenograft tumor models Gastroenterology High 24998203
2018 The SH3 domain of Fyn kinase (Fyn-SH3) interacts with the hnRNPA2 low-complexity domain despite hnRNPA2 lacking canonical SH3-binding sequences. Fyn-SH3 induces hnRNPA2 LC phase separation and is incorporated into in vitro phase-separated granules. NMR identified hnRNPA2 LC interaction sites on the surface of Fyn-SH3. In vitro microscopy, solution NMR spectroscopy, in vitro phase separation assays The Journal of biological chemistry High 30397184
2020 In vitro tyrosine phosphorylation of hnRNPA2 by Fyn reduces hnRNPA2 phase separation, prevents partitioning of hnRNPF and ch-TOG into hnRNPA2 LC droplets, and decreases aggregation of hnRNPA2 disease variants. Transport granule components hnRNPF and ch-TOG interact weakly with hnRNPA2 but partition specifically into LC droplets. Expression of Fyn kinase in C. elegans reduces neurodegeneration associated with chimeric hnRNPA2 D290V. In vitro phase separation assays, tyrosine phosphorylation assays, C. elegans neurodegeneration model with Fyn expression, NMR The EMBO journal High 33349959
2016 Drosophila model expressing disease-homologous hnRNPA2B1 mutations (Hrb98DE) in fly muscle causes progressive cytoplasmic inclusion pathology containing stress granule marker ROX8 and additional RNA-binding proteins including TDP-43. Overexpression of DNAJB6/MRJ rescues inclusion formation and prevents RBP aggregation after heat shock through a physical interaction; wild-type but not disease-mutant MRJ interacted with RBPs after heat shock. Drosophila genetic model with disease-homologous mutations, immunofluorescence for inclusions, genetic epistasis (MRJ overexpression/KO), co-immunoprecipitation after heat shock Human molecular genetics High 26744327
2022 Heterozygous frameshift variants in HNRNPA2B1 that extend the reading frame with a novel neomorphic C-terminal sequence (escaping NMD and translated) have reduced affinity for the nuclear import receptor karyopherin β2, resulting in cytoplasmic accumulation of hnRNPA2 protein in cells and animal models, causing early-onset oculopharyngeal muscular dystrophy. Frameshift variant characterization, nuclear import receptor binding assay (karyopherin β2), cellular localization by immunofluorescence, animal models Nature communications High 35484142
2023 SUMOylated HNRNPA2B1 (HNRNPA2B1SUMO) acts as an endogenous inhibitor of RPA during normal DNA replication. HNRNPA2B1SUMO associates with RPA through recognizing the SUMO-interacting motif (SIM) of RPA, inhibiting RPA accumulation at replication forks and impeding local ATR activation. DNA damage reduces HNRNPA2B1SUMO, releasing nuclear soluble RPA to chromatin and enabling ATR activation. HNRNPA2B1 hinders homologous recombination repair by limiting RPA availability. Co-IP identifying SIM-mediated interaction, chromatin fractionation, ATR activation assays, HR repair assays, PARP inhibitor sensitivity assays Molecular cell High 36702126
2020 Solution NMR showed that the two RRMs of hnRNPA2 move independently in solution without RNA. hnRNPA2 RRMs bind the minimal A2RE11 RNA weakly, with NMR shifts in both RRMs upon binding. Short A2RE RNAs or longer RNAs containing this sequence completely prevent in vitro phase separation of full-length hnRNPA2 and aggregation of disease-associated mutants. Solution NMR spectroscopy, biophysical RNA binding assays, in vitro phase separation assays with RNA addition Nucleic acids research High 32870271
2011 In pancreatic cancer cells, inhibition of Fyn kinase activity downregulated hnRNPA2B1 expression. hnRNPA2B1 binds Bcl-x mRNA and affects its splicing, promoting formation of anti-apoptotic Bcl-xL (downregulation of hnRNPA2B1 increased pro-apoptotic Bcl-xS formation and apoptosis). Overexpression of hnRNPA2B1 rescued cells from apoptosis. Kinase-dead Fyn expression, RNA interference knockdown, Bcl-x splicing assay by RT-PCR, apoptosis assays Carcinogenesis Medium 21642356
2010 Under mitochondrial respiratory stress, Akt1 phosphorylates hnRNPA2, and this phosphorylation is a crucial step for recruitment of hnRNPA2 as a transcriptional coactivator to stress target promoters (including NFκB/cRel:p50, C/EBPδ, CREB, NFAT pathways), culminating in transcription activation of nuclear genes including Cathepsin L, RyR1, Glut4 and Akt1. In vivo phosphorylation assays, chromatin immunoprecipitation at stress target promoters, transcription activation assays with dominant-negative constructs Biochimica et biophysica acta Medium 20153290
2015 hnRNPA2/B1 binds the COX-2 core promoter to activate COX-2 expression in non-small-cell lung cancer. hnRNPA2/B1 interacts directly with the transcriptional co-activator p300, which acetylates hnRNPA2/B1. Acetylation by p300 (requiring its HAT domain) enhances hnRNPA2/B1 binding to the COX-2 promoter and promotes COX-2 expression and tumor growth. ChIP (promoter binding), Co-IP (hnRNPA2B1-p300 interaction), acetylation assays with p300 HAT domain deletion mutant, shRNA/siRNA knockdown with functional readouts Molecular oncology Medium 26774881
2018 hnRNPA2 functions as a lysine acetyltransferase (KAT) that acetylates histone H4 at lysine 8 (H4K8) at telomeres under mitochondrial dysfunction. This H4K8 acetylation is associated with telomere attrition. Expression of a KAT-mutant hnRNPA2 rescued telomere length, suggesting impaired H4K8 acetylation is responsible. KAT activity assay, histone acetylation assay (H4K8), telomere length measurement, KAT-mutant hnRNPA2 expression rescue PloS one Medium 30427907
2019 hnRNPA2B1 binds the 3'-UTR of HIF-1α mRNA through its C-terminal glycine-rich domain, promoting HIF-1α translation. The small molecule MO-460 inhibits initiation of HIF-1α translation by binding to the C-terminal glycine-rich domain of hnRNPA2B1 and blocking its binding to HIF-1α mRNA 3'-UTR. RNA immunoprecipitation showing hnRNPA2B1-HIF-1α mRNA 3'UTR interaction, chemical proteomics identifying MO-460 binding site, translation assays Experimental & molecular medicine Medium 30755586
2019 M1 muscarinic receptor signaling controls hnRNPA2/B1 protein levels by regulating mRNA translation via nonsense-mediated decay regulation, not by altering mRNA levels, protein aggregation, or degradation. Genetic mouse models with decreased or increased cholinergic tone show corresponding changes in hnRNPA2/B1 protein levels. Genetic mouse models (cholinergic tone manipulation), M1 muscarinic receptor knockout, translation assays, NMD pathway analysis The Journal of neuroscience Medium 27277805
2019 hnRNPA2/B1 localization shifts from nucleus to cytoplasm during mammalian embryonic development, regulated by METTL3-dependent m6A RNA methylation. METTL3 KD blastocysts show increased mislocalization of hnRNPA2/B1, and hnRNPA2/B1 KD causes developmental arrest after the 4-cell stage with decreased OCT4 and SOX2 inner cell mass markers. Immunofluorescence localization in embryos, hnRNPA2/B1 and METTL3 knockdown with developmental readout, RNA-seq in KD blastocysts Scientific reports Medium 31201338
2020 In uninfected HEp-2 cells, hnRNPA2B1 is localized in the nucleus and is not a component of exosomes. Upon HSV-1 infection, hnRNPA2B1 is quantitatively exported to the cytoplasm where a fraction colocalizes with a Golgi marker. In ΔhnRNPA2B1 cells, there is a >10-fold reduction in HSV-1 released through the apical surface, but no significant impact on basolateral cell-to-cell transfer. Subcellular fractionation, immunofluorescence colocalization with Golgi marker, hnRNPA2B1 knockout cells, viral yield quantification Journal of virology Medium 32295924
2020 Epirubicin disrupts the interaction between hnRNPA2B1 and miR-503 in endothelial cells, leading to hnRNPA2B1 relocalization to the nucleus while miR-503 and ANXA2 are sorted into exosomes. hnRNPA2B1 negatively regulates exosomal sorting of miR-503, establishing that RNA-binding proteins can inhibit exosomal miRNA export. Biotinylated miR-503 pulldown with mass spectrometry identification, western blotting validation, knockdown systems with pulldown analysis, localization assays Cellular and molecular life sciences Medium 31894362
2024 hnRNPA2B1 is associated with stress granules (SGs) and represses their disassembly. hnRNPA2B1 absence specifically enhances arsenite-induced SG disassembly via the ubiquitin-proteasome system (not autophagy). hnRNPA2B1 interacts with core SG proteins G3BP1, G3BP2, USP10, and Caprin-1; its depletion reduces the G3BP1-USP10/Caprin-1 interaction and elevates G3BP1 ubiquitination. Hnrnpa2b1 KO in mice causes Sertoli cell-only syndrome and complete male infertility. Co-IP identifying SG protein interactions, ubiquitination assays, proteasome inhibitor experiments, autophagy inhibitor experiments, Hnrnpa2b1 KO mouse model with fertility phenotype Cell reports High 38363675
2022 In PAH pulmonary arterial smooth muscle cells, hnRNPA2B1 expression and nuclear localization are increased. hnRNPA2B1 promotes expression of mRNAs carrying three defined binding motifs involved in different aspects of the cell cycle. RNA immunoprecipitation confirmed binding to target mRNAs. hnRNPA2B1 silencing decreased target mRNA levels and reduced proliferation and resistance to apoptosis in PAH-PASMC. In vivo hnRNPA2B1 inhibition in lungs rescued pulmonary hypertension in rats. RNA immunoprecipitation, bioinformatics motif analysis, hnRNPA2B1 silencing with proliferation/apoptosis readouts, immunofluorescence localization, monocrotaline rat model Circulation Medium 35993245
2024 hnRNPA2B1 mediates nuclear export of m6A-tagged mRNAs through the ALYREF/NXF1 complex. ISGylation of hnRNPA2B1 (mediated by PCAT6 serving as scaffold between ISG15 and hnRNPA2B1) protects hnRNPA2B1 from ubiquitination-mediated proteasomal degradation, enhancing its ability to selectively export m6A-modified mRNAs. Co-IP (PCAT6-ISG15-hnRNPA2B1 complex, hnRNPA2B1-ALYREF/NXF1), ISGylation assay, ubiquitination assay, nuclear mRNA export assay, hnRNPA2B1 knockdown Advanced science (Weinheim, Baden-Wurttemberg, Germany) Medium 38626369
2022 hnRNPA2B1 mediates microRNA processing (specifically miR-92a-2-5p and miR-373-3p) via interaction with DGCR8 (confirmed by Co-IP). These processed miRNAs are transported in exosomes to recipient monocytes or mesenchymal stem cells to activate osteoclastogenesis and suppress osteoblastogenesis by inhibiting IRF8 or RUNX2. RNA pull-down, RIP assays for hnRNPA2B1-pri-miRNA interaction, Co-IP for hnRNPA2B1-DGCR8, exosome isolation and characterization, luciferase assay for miRNA targets Theranostics Medium 36451863
2020 HNRNPA2B1 interacts with KRAS mRNA and facilitates its nuclear export and translation in colorectal cancer. The lncRNA CRNDE maintains HNRNPA2B1 protein stability by inhibiting E3 ubiquitin ligase TRIM21-mediated K63 ubiquitination-dependent degradation. The CRNDE/hnRNPA2B1 axis activates MAPK signaling through KRAS. RNA immunoprecipitation for KRAS mRNA binding, nuclear export assay, ubiquitination assay identifying TRIM21 as E3 ligase, Co-IP, CRISPR KO experiments Cell death & disease Medium 37716979
2020 Linc01232 physically interacts with the RNA recognition motif 2 domain of HNRNPA2B1 (680-890 nt fragment) and inhibits its ubiquitin-mediated degradation, stabilizing HNRNPA2B1. Stabilized HNRNPA2B1 participates in alternative splicing of A-Raf, regulating the MAPK/ERK signaling pathway. RNA pull-down, RIP assays, domain mapping of HNRNPA2B1 interaction region, ubiquitination assays, RNA-seq for alternative splicing Cancer letters Medium 32814086
2022 hnRNPA2/B1 regulates copper homeostasis by modulating the abundance of Cu(I)-transporter ATP7A via the 3' UTR of the ATP7A transcript in an isoform-dependent manner. Downregulation of B1 and B1b isoforms is sufficient to elevate ATP7A, while overexpression of either hnRNPA2 or hnRNPB1 isoforms decreases ATP7A mRNA levels. siRNA knockdown of specific isoforms, isoform-specific overexpression, 3'UTR reporter assay, mRNA and protein quantification, copper level measurement Frontiers in molecular biosciences Medium 36545508
2025 hnRNPA2B1 is a sensor for the metabolite adenine in the nucleus. Adenine directly binds and activates hnRNPA2B1, which is then recruited to Il1b enhancers. hnRNPA2B1 increases Il1b enhancer chromatin accessibility by binding and recruiting nucleolin and the demethylase FTO to mediate Il1b enhancer DNA N6-methyladenosine (6mA) demethylation, thereby increasing IL-1β production during bacterial infection. Large-scale metabolite-hnRNPA2B1 interaction screen, direct binding assay (adenine-hnRNPA2B1), ChIP at Il1b enhancers, chromatin accessibility assay, Co-IP with nucleolin and FTO, myeloid-specific cKO mice with bacterial infection Cell metabolism High 39814017
2022 A hnRNPA2B1 agonist compound PAC5 binds near Asp49 in the RNA recognition motif of hnRNPA2B1, activating it and promoting its translocation to the cytoplasm where it initiates the TBK1-IRF3 pathway, leading to type I IFN production with antiviral activity against HBV and SARS-CoV-2. Binding site characterization by structural analysis (near Asp49 in RRM), nuclear-cytoplasmic fractionation, TBK1-IRF3 activation assay, in vivo HBV and hamster SARS-CoV-2 models Protein & cell Medium 36726760
2024 hnRNPA2B1 stabilizes SREBP2 mRNA via m6A modification and similarly stabilizes LDLR mRNA in an m6A-dependent manner, triggering de novo cholesterol synthesis through HMGCR induction and promoting glioma stemness. RNA immunoprecipitation for SREBP2/LDLR mRNA binding, m6A MeRIP sequencing, RNA stability assay, hnRNPA2B1 ablation with transcriptome and lipidomic readouts Neuro-oncology Medium 38070488
2017 HNRNPA2B1 mediates exclusion of cassette exon 11 from MST1R pre-mRNA (validated by minigene model), generating the RON∆165 isoform that activates Akt/PKB signaling in head and neck cancer. Depletion of HNRNPA2B1 by CRISPR/Cas9 causes exon 11 inclusion, reducing RON∆165 and inhibiting Akt/PKB signaling, leading to reduced EMT. CRISPR/Cas9 knockout, MST1R-minigene splicing assay, isoform-specific RT-PCR, Akt/PKB signaling assays Laboratory investigation Medium 32669614
2017 Nm23-H1 increases the protein stability of hnRNPA2/B1 and both are co-recruited to the 5'UTR of Sp1 mRNA to regulate its cap-independent (IRES-mediated) translational activity in lung cancer cells. Co-IP of Nm23-H1 and hnRNPA2/B1, RNA immunoprecipitation of 5'UTR of Sp1 mRNA, IRES-based reporter assay, protein stability assay Scientific reports Medium 28831131
2014 hnRNP-A2/B1 binds directly to the ASCL1 mRNA 5'- and 3'-UTRs (identified by RNA pulldown and MALDI/TOF-MS) and functions as a key positive regulator of ASCL1 expression. Downregulation of hnRNP-A2/B1 during hypoxia is associated with post-transcriptional suppression of hASH1 synthesis. RNA pulldown with MALDI/TOF-MS identification, reporter gene assays for 5'- and 3'-UTR function, siRNA knockdown, hypoxia exposure The Journal of biological chemistry Medium 25124043
2023 CSNK1D (casein kinase 1 delta) phosphorylates HNRNPA2B1 to enhance its stability. Phosphorylated/stabilized HNRNPA2B1 promotes maturation of miR-25-3p and miR-93-5p by recognizing m6A marks on primary miR-25/93 transcripts. miR-93-5p targets BAMBI to activate TGF-β pathway; miR-25-3p targets FOXO3 to inactivate FOXO pathway. Mass spectrometry identifying CSNK1D as kinase, phosphorylation and stability assays, m6A RIP for pri-miRNA binding, pri-miRNA processing assay Cellular and molecular life sciences Medium 37208565
2013 PARP1 and HNRNPA2B1 specifically bind DNA sequences at the termini of 'forum domains' — chromosomal regions of 50-250 kb flanked by DNA double-strand break hot spots that contain coordinately expressed genes, suggesting a structural role in coordinated transcription of gene clusters. Genome-wide mapping of blunt-ended DSBs, ChIP-seq for PARP1 and HNRNPA2B1 binding at domain termini PLoS genetics Medium 23593027
2024 hnRNPA2B1 interacts with PABPC1, and this complex coordinates with the cap-binding eIF4F complex to facilitate translation of CIP2A, DLAT, and GPX1 mRNAs independent of m6A modification in gastric cancer cells. H. pylori infection induces hnRNPA2B1 upregulation through NF-κB recruitment to its promoter. Mass spectrometry and Co-IP for hnRNPA2B1-PABPC1 interaction, Ribo-seq and polysome profiling for translational regulation, RIP-seq for mRNA targets, m6A epitranscriptomic microarray Advanced science (Weinheim, Baden-Wurttemberg, Germany) Medium 38887155

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nature communications 1620 24356509
2015 HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events. Cell 1278 26321680
2013 Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature 1225 23455423
2018 Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation. Molecular cell 328 29358076
2019 Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. Science (New York, N.Y.) 309 31320558
2015 The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei. Cell 245 26544936
2021 Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Molecular cell 160 34453888
2022 Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression. Molecular cancer 156 35279145
2016 Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. Neuron 154 27773581
2021 HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA. Journal of hematology & oncology 131 33794982
2020 Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1. Journal of experimental & clinical cancer research : CR 116 32698890
2003 Transgenes encompassing dual-promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing. Genomics 109 12906852
2019 HNRNPA2/B1 is upregulated in endocrine-resistant LCC9 breast cancer cells and alters the miRNA transcriptome when overexpressed in MCF-7 cells. Scientific reports 88 31263129
2020 CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nature communications 87 32796831
1995 Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1. Genomics 83 7789969
2020 Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis. Molecular therapy : the journal of the American Society of Gene Therapy 82 32246902
2011 Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer. Carcinogenesis 69 21642356
2020 Linc01232 promotes the metastasis of pancreatic cancer by suppressing the ubiquitin-mediated degradation of HNRNPA2B1 and activating the A-Raf-induced MAPK/ERK signaling pathway. Cancer letters 65 32814086
2016 The antioxidant uncoupling protein 2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreas cancer cells to glycolysis inhibition. Free radical biology & medicine 63 27989750
2017 HNRNPA2B1 regulates the epithelial-mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway. Cancer cell international 60 28077929
2021 hnRNPA2B1-Mediated Extracellular Vesicles Sorting of miR-122-5p Potentially Promotes Lung Cancer Progression. International journal of molecular sciences 59 34884671
2020 Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Cancer letters 59 32006618
2024 N6-methyladenosine reader hnRNPA2B1 recognizes and stabilizes NEAT1 to confer chemoresistance in gastric cancer. Cancer communications (London, England) 58 38512764
2020 Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration. The EMBO journal 57 33349959
2019 Functional roles of hnRNPA2/B1 regulated by METTL3 in mammalian embryonic development. Scientific reports 57 31201338
2014 Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells. Gastroenterology 57 24998203
2017 Splicing factor hnRNPA2B1 contributes to tumorigenic potential of breast cancer cells through STAT3 and ERK1/2 signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 55 28351333
2023 HNRNPA2B1-mediated m6A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis. Journal of translational medicine 54 37308993
2020 hnRNPA2B1 inhibits the exosomal export of miR-503 in endothelial cells. Cellular and molecular life sciences : CMLS 50 31894362
2007 Correlation of DNA methylation with histone modifications across the HNRPA2B1-CBX3 ubiquitously-acting chromatin open element (UCOE). Epigenetics 50 18032920
2020 Apigenin by targeting hnRNPA2 sensitizes triple-negative breast cancer spheroids to doxorubicin-induced apoptosis and regulates expression of ABCC4 and ABCG2 drug efflux transporters. Biochemical pharmacology 47 33011162
2021 HNRNPA2B1 regulates tamoxifen- and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells. Cancer letters 45 34273466
2018 Structural characterization of the D290V mutation site in hnRNPA2 low-complexity-domain polymers. Proceedings of the National Academy of Sciences of the United States of America 45 30279180
2010 Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets. Biochimica et biophysica acta 44 20153290
2021 HNRNPA2B1, as a m6A Reader, Promotes Tumorigenesis and Metastasis of Oral Squamous Cell Carcinoma. Frontiers in oncology 42 34631545
2022 HNRNPA2B1: RNA-Binding Protein That Orchestrates Smooth Muscle Cell Phenotype in Pulmonary Arterial Hypertension. Circulation 40 35993245
2015 hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers. Molecular oncology 39 26774881
2024 HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 38 38626369
2022 Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy. Nature communications 38 35484142
2021 hnRNPA2B1 Promotes Colon Cancer Progression via the MAPK Pathway. Frontiers in genetics 38 34630502
2019 LncRNA SOX2-OT regulates proliferation and metastasis of nasopharyngeal carcinoma cells through miR-146b-5p/HNRNPA2B1 pathway. Journal of cellular biochemistry 38 31099048
2020 Increased expression of YTHDF1 and HNRNPA2B1 as potent biomarkers for melanoma: a systematic analysis. Cancer cell international 37 32549786
2018 The SH3 domain of Fyn kinase interacts with and induces liquid-liquid phase separation of the low-complexity domain of hnRNPA2. The Journal of biological chemistry 36 30397184
2023 Mutant p53 activates hnRNPA2B1-AGAP1-mediated exosome formation to promote esophageal squamous cell carcinoma progression. Cancer letters 34 37030635
2022 HNRNPA2B1 inhibited SFRP2 and activated Wnt-β/catenin via m6A-mediated miR-106b-5p processing to aggravate stemness in lung adenocarcinoma. Pathology, research and practice 33 35364458
2024 hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility. Cell reports 32 38363675
2022 HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma. Journal of translational medicine 31 36401285
2021 hnRNPA2B1 regulates the alternative splicing of BIRC5 to promote gastric cancer progression. Cancer cell international 31 34044823
2020 The HNRNPA2B1-MST1R-Akt axis contributes to epithelial-to-mesenchymal transition in head and neck cancer. Laboratory investigation; a journal of technical methods and pathology 31 32669614
2023 Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. Signal transduction and targeted therapy 30 36658134
2023 SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses. Molecular cell 30 36702126
2019 Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition. Experimental & molecular medicine 30 30755586
2022 m6A reader hnRNPA2B1 drives multiple myeloma osteolytic bone disease. Theranostics 29 36451863
2020 hnRNPA2B1 Associated with Recruitment of RNA into Exosomes Plays a Key Role in Herpes Simplex Virus 1 Release from Infected Cells. Journal of virology 29 32295924
2017 Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis. Neuro-degenerative diseases 29 29131108
2016 Cholinergic Regulation of hnRNPA2/B1 Translation by M1 Muscarinic Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 29 27277805
2024 Cholesterol homeostasis confers glioma malignancy triggered by hnRNPA2B1-dependent regulation of SREBP2 and LDLR. Neuro-oncology 28 38070488
2013 DNA double-strand breaks coupled with PARP1 and HNRNPA2B1 binding sites flank coordinately expressed domains in human chromosomes. PLoS genetics 28 23593027
2010 BRCA1 modulates the expression of hnRNPA2B1 and KHSRP. Cell cycle (Georgetown, Tex.) 28 21099359
2018 Long non-coding RNA CACNA1G-AS1 promotes cell migration, invasion and epithelial-mesenchymal transition by HNRNPA2B1 in non-small cell lung cancer. European review for medical and pharmacological sciences 27 29509247
2017 Familial Early-Onset Paget's Disease of Bone Associated with a Novel hnRNPA2B1 Mutation. Calcified tissue international 27 28389692
2016 Genetic interaction of hnRNPA2B1 and DNAJB6 in a Drosophila model of multisystem proteinopathy. Human molecular genetics 26 26744327
2023 HNRNPA2B1-mediated m6A modification of FOXM1 promotes drug resistance and inhibits ferroptosis in endometrial cancer via regulation of LCN2. Functional & integrative genomics 24 38091112
2009 Overexpression of hnRNPA2/B1 in bronchoscopic specimens: a potential early detection marker in lung cancer. Anticancer research 24 19414390
2022 A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicron in vivo. Protein & cell 22 36726760
2020 Effect of hnRNPA2/B1 on the proliferation and apoptosis of glioma U251 cells via the regulation of AKT and STAT3 pathways. Bioscience reports 22 32463472
2023 hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner. Journal of translational medicine 20 38017546
2023 Identification of a novel heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) ligand that disrupts HnRNPA2B1/nucleic acid interactions to inhibit the MDMX-p53 axis in gastric cancer. Pharmacological research 19 36791898
2021 lncRNA PCAT6 facilitates cell proliferation and invasion via regulating the miR-326/hnRNPA2B1 axis in liver cancer. Oncology letters 19 33907581
2020 Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid-liquid phase separation and aggregation. Nucleic acids research 19 32870271
2024 Helicobacter Pylori-Enhanced hnRNPA2B1 Coordinates with PABPC1 to Promote Non-m6A Translation and Gastric Cancer Progression. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 18 38887155
2023 NUF2 promotes tumorigenesis by interacting with HNRNPA2B1 via PI3K/AKT/mTOR pathway in ovarian cancer. Journal of ovarian research 18 36670423
2023 CSNK1D-mediated phosphorylation of HNRNPA2B1 induces miR-25-3p/miR-93-5p maturation to promote prostate cancer cell proliferation and migration through m6A-dependent manner. Cellular and molecular life sciences : CMLS 18 37208565
2023 Activation of the HNRNPA2B1/miR-93-5p/FRMD6 axis facilitates prostate cancer progression in an m6A-dependent manner. Journal of Cancer 18 37215455
2021 lncRNA ST3GAL6‑AS1 promotes invasion by inhibiting hnRNPA2B1‑mediated ST3GAL6 expression in multiple myeloma. International journal of oncology 18 33649796
2020 Apoptosis in Cancer Cells Is Induced by Alternative Splicing of hnRNPA2/B1 Through Splicing of Bcl-x, a Mechanism that Can Be Stimulated by an Extract of the South African Medicinal Plant, Cotyledon orbiculata. Frontiers in oncology 18 33163396
2025 Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity. Cell metabolism 16 39814017
2021 HnRNPA2B1 promotes the proliferation of breast cancer MCF-7 cells via the STAT3 pathway. Journal of cellular biochemistry 16 33399232
2021 The RNA N6 -methyladenosine modulator HNRNPA2B1 is involved in the development of non-small cell lung cancer. Clinical and experimental pharmacology & physiology 16 34717005
2021 HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6. iScience 16 34805798
2020 The novel long noncoding RNA Lnc19959.2 modulates triglyceride metabolism-associated genes through the interaction with Purb and hnRNPA2B1. Molecular metabolism 16 32302712
2018 hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction. PloS one 16 30427907
2023 HnRNPA2B1 Aggravates Inflammation by Promoting M1 Macrophage Polarization. Nutrients 15 37049395
2022 Identification of miR-30c-5p as a tumor suppressor by targeting the m6 A reader HNRNPA2B1 in ovarian cancer. Cancer medicine 15 36259156
2021 LncRNA AC105942.1 Downregulates hnRNPA2/B1 to Attenuate Vascular Smooth Muscle Cells Proliferation. DNA and cell biology 15 33781092
2017 Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression. Scientific reports 15 28831131
2024 LSD1 modulates the bone metastasis of breast cancer cells through hnRNPA2B1-mediated sorting of exosomal miRNAs. Cell death discovery 14 38448424
2023 CRNDE mediated hnRNPA2B1 stability facilitates nuclear export and translation of KRAS in colorectal cancer. Cell death & disease 14 37716979
2020 Identification of anti-tumoral feedback loop between VHLα and hnRNPA2B1 in renal cancer. Cell death & disease 14 32826868
2022 Neddylation-mediated degradation of hnRNPA2B1 contributes to hypertriglyceridemia pancreatitis. Cell death & disease 13 36220838
2024 HNRNPA2B1 and HNRNPR stabilize ASCL1 in an m6A-dependent manner to promote neuroblastoma progression. Biochimica et biophysica acta. Molecular basis of disease 12 38331110
2024 DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression. Oncogene 12 38811846
2015 Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin. ACS chemical neuroscience 12 26030368
2025 Small molecule inhibitors of hnRNPA2B1-RNA interactions reveal a predictable sorting of RNA subsets into extracellular vesicles. Nucleic acids research 11 40103230
2014 Shutdown of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia. The Journal of biological chemistry 11 25124043
2023 m6A reader HNRNPA2B1 destabilization of ATG4B regulates autophagic activity, proliferation and olaparib sensitivity in breast cancer. Experimental cell research 10 36693492
2023 HIF-1α inhibition by MO-2097, a novel chiral-free benzofuran targeting hnRNPA2B1. Journal of advanced research 10 37977260
2023 Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway. Immunity & ageing : I & A 10 37990246
2022 Heterogeneous nuclear ribonucleoprotein hnRNPA2/B1 regulates the abundance of the copper-transporter ATP7A in an isoform-dependent manner. Frontiers in molecular biosciences 10 36545508
2017 Perfecting prediction of mutational impact on the aggregation propensity of the ALS-associated hnRNPA2 prion-like protein. FEBS letters 10 28542905

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