Affinage

HNRNPA2B1

Heterogeneous nuclear ribonucleoproteins A2/B1 · UniProt P22626

Length
353 aa
Mass
37.4 kDa
Annotated
2026-04-28
100 papers in source corpus 40 papers cited in narrative 40 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

HNRNPA2B1 is a multifunctional RNA-binding protein that integrates epitranscriptomic reading, alternative splicing, mRNA stability control, nuclear export, and innate immune sensing. As a nuclear m6A reader, it recognizes m6A-modified transcripts to direct alternative splicing outcomes and promotes pri-miRNA processing through interaction with the Microprocessor component DGCR8, while ISGylated HNRNPA2B1 mediates nuclear export of m6A-tagged mRNAs via the ALYREF/NXF1 pathway (PMID:26321680, PMID:36451863, PMID:38626369). Its low-complexity prion-like domain undergoes reversible cross-β polymerization and liquid–liquid phase separation regulated by Fyn kinase-mediated tyrosine phosphorylation and RNA binding; the D290V disease mutation stabilizes pathogenic steric-zipper fibrils that drive cytoplasmic inclusions causing multisystem proteinopathy including oculopharyngeal muscular dystrophy, while frameshift variants that impair karyopherin β2-dependent nuclear import cause early-onset OPMD through cytoplasmic mislocalization (PMID:23455423, PMID:32796831, PMID:33349959, PMID:35484142). Upon DNA virus infection, HNRNPA2B1 senses viral DNA, is demethylated at Arg226 by JMJD6, translocates to the cytoplasm, and activates the TBK1–IRF3–IFN-α/β innate immune pathway; during bacterial infection, adenine binding recruits it to Il1b enhancers to promote chromatin remodeling and IL-1β transcription (PMID:31320558, PMID:39814017). SUMOylated HNRNPA2B1 sequesters RPA from replication forks to restrain ATR activation and homologous recombination during unperturbed replication, and it stabilizes stress granules by maintaining G3BP1–USP10/Caprin-1 interactions and opposing G3BP1 ubiquitination (PMID:36702126, PMID:38363675).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2010 Medium

    Establishing that HNRNPA2B1 functions beyond canonical RNA processing as a phosphorylation-dependent transcriptional coactivator at stress-responsive promoters answered whether this RNA-binding protein could directly regulate transcription.

    Evidence Akt1 in vitro kinase assay, promoter ChIP, siRNA knockdown in C2C12 mitochondrial stress model

    PMID:20153290

    Open questions at the time
    • Single lab study; coactivator mechanism not confirmed at other gene sets
    • Direct promoter-binding domain not mapped
    • Whether Akt1 phosphorylation site is the sole regulatory modification unknown
  2. 2013 High

    Discovery that prion-like domain mutations (D290V) create pathogenic steric zippers that accelerate amyloid fibril formation and cross-seed wild-type protein established a molecular basis for HNRNPA2B1-linked multisystem proteinopathy and stress granule pathology.

    Evidence In vitro fibril assembly, cross-seeding assays, Drosophila and cell models, exome sequencing of disease families

    PMID:23455423

    Open questions at the time
    • Atomic-resolution fibril structure not yet determined at this stage
    • Mechanism of inclusion clearance unknown
    • Whether other PrLD mutations cause similar pathology untested
  3. 2015 High

    Identification of HNRNPA2B1 as a nuclear m6A reader that influences alternative splicing and pri-miRNA processing via DGCR8 interaction unified its RNA regulatory roles under epitranscriptomic control, answering how m6A marks are decoded in the nucleus.

    Evidence RIP, in vitro RNA-binding assays, METTL3 depletion epistasis, co-IP with DGCR8

    PMID:26321680

    Open questions at the time
    • Whether m6A reading requires direct base contact or indirect structural recognition debated
    • Full spectrum of m6A-dependent splicing targets uncharacterized
    • Structural basis of m6A recognition not resolved
  4. 2015 High

    Demonstration that the low-complexity domain forms labile cross-β polymers with similar conformation in hydrogels and native nuclei established that phase-separation-competent polymerization is a physiological property, not an artifact.

    Evidence Hydrogel polymer formation, molecular footprinting of recombinant and nuclear hnRNPA2

    PMID:26544936

    Open questions at the time
    • Functional consequence of nuclear polymerization not directly demonstrated
    • Relationship between polymerization state and RNA processing function unclear
  5. 2016 High

    Drosophila modeling of disease-homologous mutations showed progressive muscle inclusions containing stress granule markers and TDP-43, and genetic rescue by DNAJB6 ortholog MRJ, establishing chaperone-dependent inclusion clearance as a therapeutic axis.

    Evidence Drosophila disease-homologous mutagenesis, MRJ overexpression/loss-of-function epistasis, immunofluorescence

    PMID:26744327

    Open questions at the time
    • Whether MRJ directly disaggregates hnRNPA2B1 fibrils or acts indirectly unknown
    • Mammalian DNAJB6 rescue not confirmed in this study
  6. 2018 High

    Solid-state NMR and Fyn-SH3 interaction studies resolved two key questions: that wild-type LC domain forms in-register cross-β polymers with a charged Asp290 core (explaining D290V pathogenicity), and that Fyn kinase SH3 domain induces phase separation through non-canonical contacts, linking kinase signaling to granule assembly.

    Evidence Solid-state NMR with segmental isotope labeling; solution NMR of Fyn-SH3/LC interaction; in vitro phase separation microscopy

    PMID:30279180 PMID:30397184

    Open questions at the time
    • Whether Fyn-induced phase separation occurs in vivo not demonstrated
    • Full atomic model of fibril not yet available
  7. 2019 High

    Discovery that HNRNPA2B1 functions as a nuclear DNA sensor for viral infection—requiring JMJD6-mediated Arg226 demethylation for cytoplasmic translocation and TBK1–IRF3–IFN-α/β activation—revealed an unexpected innate immune function for this RNA-binding protein.

    Evidence Co-IP, nuclear/cytoplasmic fractionation, JMJD6 demethylation assay, gene KO, viral infection models

    PMID:31320558

    Open questions at the time
    • How hnRNPA2B1 discriminates viral from host DNA not determined
    • Whether DNA-sensing function requires m6A reading activity unknown
  8. 2020 High

    CryoEM structure of the wild-type LC fibril core and crystal structure of D290V steric zipper explained at atomic resolution why wild-type fibrils are labile (kinked cross-β with non-covalent crosslinks) while D290V fibrils are pathologically stable, completing the structural basis of disease.

    Evidence Cryo-EM fibril structure, crystal structure of D290V peptide segment, energetic calculations

    PMID:32796831

    Open questions at the time
    • Whether therapeutic disaggregation can target D290V-specific structure untested
    • Structure of full-length protein in fibril context unknown
  9. 2020 High

    Demonstrating that RNA binding through both RRMs completely abolishes phase separation and disease-mutant aggregation in vitro established RNA as a physiological regulator that opposes pathological assembly, answering why loss of RNA engagement could be toxic.

    Evidence Solution NMR, biophysical binding assays, fluorescence-based phase separation assays

    PMID:32870271

    Open questions at the time
    • Whether RNA depletion triggers aggregation in neurons in vivo not shown
    • Which endogenous RNAs are most protective unknown
  10. 2020 High

    Fyn kinase-mediated tyrosine phosphorylation was shown to reduce phase separation, prevent transport granule component partitioning, and rescue D290V neurodegeneration in C. elegans (dependent on tdp-1), connecting a specific kinase to both phase behavior and in vivo neuroprotection.

    Evidence In vitro phosphorylation/phase separation, C. elegans Fyn expression/tdp-1 epistasis, NMR

    PMID:33349959

    Open questions at the time
    • Specific tyrosine residues conferring protection not fully mapped
    • Whether Fyn-based therapeutic strategy translates to mammalian neurodegeneration untested
  11. 2021 High

    Identification of HNRNPA2B1 as the linker connecting oligomeric tau to m6A-modified RNA, with knockdown preventing tau-induced translational suppression and neurodegeneration, established a new pathogenic axis in Alzheimer's disease.

    Evidence Cry2-based optogenetic tau oligomerization, proteomics, Co-IP, neuronal KD, human AD brain tissue validation

    PMID:34453888

    Open questions at the time
    • Whether disrupting the oTau–A2B1 interaction is therapeutically viable unknown
    • Mechanism by which the ternary complex suppresses translation not detailed
  12. 2022 High

    Heterozygous frameshift variants that extend the C-terminus reduce karyopherin β2 binding affinity and cause cytoplasmic mislocalization, producing early-onset OPMD through a distinct (non-fibrillization) mechanism, broadening the disease model beyond prion-like aggregation.

    Evidence Patient genetics, nuclear import assays, karyopherin β2 binding measurements, cell and animal models

    PMID:35484142

    Open questions at the time
    • Whether cytoplasmic hnRNPA2B1 in these patients eventually fibrillizes not resolved
    • Full phenotypic spectrum of frameshift versus missense disease not compared
  13. 2023 High

    SUMOylated HNRNPA2B1 was found to sequester RPA via its SUMO-interacting motif, restraining ATR activation and homologous recombination at replication forks; DNA damage reverses this by reducing SUMOylation, revealing a replication stress regulatory circuit.

    Evidence Reciprocal Co-IP, SIM mapping, RPA chromatin assays, ATR and HR functional readouts, PARP inhibitor sensitivity

    PMID:36702126

    Open questions at the time
    • Which SUMO E3 ligase and SENP deconjugase regulate this switch unknown
    • Whether this function is linked to its RNA-binding activities unaddressed
  14. 2024 Medium

    HNRNPA2B1 was shown to stabilize stress granules by maintaining G3BP1–USP10/Caprin-1 interactions and opposing G3BP1 ubiquitination; knockout in mice causes Sertoli cell-only syndrome and male infertility, establishing an essential in vivo physiological role.

    Evidence Co-IP, ubiquitination assays, live-cell SG imaging, KO mouse testis histology

    PMID:38363675

    Open questions at the time
    • Mechanism connecting SG regulation to spermatogenesis failure not established
    • E3 ligase responsible for G3BP1 ubiquitination in this context not identified
  15. 2024 Medium

    ISGylation was found to protect HNRNPA2B1 from ubiquitin-dependent degradation and enable selective nuclear export of m6A-tagged mRNAs via ALYREF/NXF1, while also modulating translational regulation of specific mRNAs, establishing ISGylation as a functional switch between degradation and export functions.

    Evidence ISGylation and ubiquitination assays, nuclear export assays, RIP, ALYREF/NXF1 complex characterization

    PMID:31926942 PMID:38626369

    Open questions at the time
    • Whether ISGylation and SUMOylation compete for the same or different functions unaddressed
    • ISGylation sites not fully mapped
  16. 2025 Medium

    Adenine was identified as a direct metabolite ligand that activates HNRNPA2B1 for recruitment to Il1b enhancers, where it recruits nucleolin and FTO to demethylate DNA 6mA and open chromatin, establishing a metabolite–RNA-binding protein–chromatin remodeling axis in antibacterial immunity.

    Evidence Large-scale metabolite screen, binding assays, ChIP, ATAC-seq, 6mA methylation assay, myeloid-specific cKO mice with infection

    PMID:39814017

    Open questions at the time
    • Whether adenine sensing is specific to macrophages or generalizable unknown
    • Structural basis of adenine–hnRNPA2B1 binding not resolved
    • Relationship to its RNA m6A-reading function at the same loci unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include how HNRNPA2B1 integrates its diverse post-translational modifications (SUMOylation, ISGylation, phosphorylation, neddylation, acetylation) to coordinate its RNA processing, innate immune, and replication stress functions; whether its m6A-reading and DNA-sensing activities share a structural basis; and how RNA versus DNA ligand selectivity is achieved.
  • No integrated structural model of full-length protein with ligands
  • No systematic mapping of PTM crosstalk
  • Relative contributions of splicing, export, and stability functions to specific disease phenotypes unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 6 GO:0003677 DNA binding 3 GO:0140110 transcription regulator activity 3 GO:0098772 molecular function regulator activity 2 GO:0140299 molecular sensor activity 1
Localization
GO:0005634 nucleus 5 GO:0005829 cytosol 4 GO:0005694 chromosome 2
Pathway
R-HSA-8953854 Metabolism of RNA 5 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-162582 Signal Transduction 2 R-HSA-392499 Metabolism of proteins 2 R-HSA-73894 DNA Repair 1
Partners
DGCR8FYNG3BP1JMJD6KRASPABPC1RPA1TDP-43
Complex memberships
ALYREF/NXF1 mRNA export complexMicroprocessor (via DGCR8)

Evidence

Reading pass · 40 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2015 HNRNPA2B1 acts as a nuclear reader of the m6A mark: it binds m6A-bearing RNAs in vivo and in vitro with a biochemical footprint matching the m6A consensus motif, elicits alternative splicing effects similar to the m6A writer METTL3, binds m6A marks in primary miRNA transcripts, interacts with the Microprocessor complex protein DGCR8, and promotes primary miRNA (pri-miRNA) processing. RNA immunoprecipitation (RIP), in vitro RNA-binding assays, alternative splicing analysis, co-immunoprecipitation with DGCR8, METTL3 depletion epistasis Cell High 26321680
2013 Mutations in the prion-like domain (PrLD) of hnRNPA2B1 (e.g., D290V) strengthen a steric zipper motif, accelerating formation of self-seeding amyloid-like fibrils that cross-seed wild-type hnRNPA2 polymerization, promote excess incorporation into stress granules, and drive cytoplasmic inclusion formation in animal models causing multisystem proteinopathy. In vitro fibril assembly assays, cross-seeding experiments, Drosophila and cell models of inclusion formation, exome sequencing of disease families Nature High 23455423
2019 Upon DNA virus infection, nuclear hnRNPA2B1 senses viral DNA, homodimerizes, is demethylated at arginine-226 by the arginine demethylase JMJD6, and translocates to the cytoplasm where it activates the TBK1-IRF3 pathway to induce IFN-α/β production. Additionally, hnRNPA2B1 facilitates m6A modification and nucleocytoplasmic trafficking of CGAS, IFI16, and STING mRNAs to amplify antiviral signaling. Co-immunoprecipitation, nuclear/cytoplasmic fractionation, gene knockdown/knockout, in vitro demethylation assay, viral infection models Science High 31320558
2015 The low-complexity (LC) domain of hnRNPA2 polymerizes into labile, amyloid-like fibers in hydrogels; molecular footprinting of recombinant polymers and isolated nuclei reveals that the LC domain adopts a similar conformation in both states, suggesting biologically relevant polymerization in the nucleus. Hydrogel polymer formation, molecular footprinting, analysis of native hnRNPA2 in isolated nuclei Cell High 26544936
2020 CryoEM structure of the hnRNPA2 LC domain fibril core reveals kinked chains forming cross-β sheets with non-covalent crosslinking that disfavor pathogenic steric zippers, making these fibrils less stable than pathogenic amyloid. The D290V disease mutation fundamentally alters the fibril structure to a more stable energetic state, explaining its pathogenicity. Cryo-electron microscopy (cryoEM), crystal structure of D290V segment, energetic calculations, in vitro hydrogel assay Nature Communications High 32796831
2018 The SH3 domain of Fyn kinase (Fyn-SH3) interacts with the low-complexity domain of hnRNPA2 through non-canonical contacts (hnRNPA2 lacks canonical SH3-binding sequences), induces hnRNPA2 LC phase separation in vitro, and is incorporated into hnRNPA2 LC phase-separated granules. In vitro microscopy, solution NMR spectroscopy, identification of hnRNPA2 LC interaction sites on Fyn-SH3 surface Journal of Biological Chemistry High 30397184
2020 Tyrosine phosphorylation of hnRNPA2 (by Fyn kinase) reduces its phase separation, prevents partitioning of transport granule components hnRNPF and ch-TOG into hnRNPA2 LC droplets, and decreases aggregation of disease variants. Expression of Fyn in C. elegans reduces neurodegeneration caused by hnRNPA2 D290V, and this neurodegeneration is rescued by loss of tdp-1, indicating gain-of-function toxicity. In vitro phosphorylation and phase separation assays, C. elegans genetic epistasis (Fyn expression, tdp-1 loss-of-function), NMR EMBO Journal High 33349959
2018 Solid-state NMR with segmental isotope labeling demonstrates that wild-type hnRNPA2 LC domain forms in-register cross-β polymers at physiological pH, with Asp290 charged and immobilized in the polymer core. The D290V mutant forms thermodynamically more stable polymers, consistent with removal of destabilizing electrostatic interactions causing disease-prone self-association. Solid-state NMR spectroscopy, segmental isotope labeling, electron microscopy PNAS High 30279180
2021 Oligomeric tau (oTau) associates with HNRNPA2B1, which functions as a linker connecting oTau with m6A-modified RNA transcripts. Knockdown of HNRNPA2B1 prevents oTau from associating with m6A RNA, prevents oTau-induced reduction of protein synthesis, and reduces oTau-induced neurodegeneration. The oTau-HNRNPA2B1-m6A complex is increased up to 5-fold in Alzheimer's disease brains. Cry2-based optogenetics to induce tau oligomers, proteomic analysis, co-immunoprecipitation, neuronal knockdown with phenotypic readout, human brain tissue analysis Molecular Cell High 34453888
2022 Heterozygous frameshift variants in HNRNPA2B1 that extend the reading frame produce neomorphic C-terminal sequences that reduce affinity for the nuclear import receptor karyopherin β2, resulting in cytoplasmic accumulation of hnRNPA2/B1 protein and causing early-onset oculopharyngeal muscular dystrophy (OPMD). Unlike missense variants, these frameshift variants do not increase fibrillization propensity. Patient genetics, nuclear import assays, karyopherin β2 binding affinity measurements, cell and animal model localization studies, fibril assembly assays Nature Communications High 35484142
2023 SUMOylation of HNRNPA2B1 enables it to associate with RPA (replication protein A) through recognizing the SUMO-interacting motif (SIM) of RPA, inhibiting RPA accumulation at replication forks and impeding local ATR activation during normal replication. DNA damage reduces HNRNPA2B1 SUMOylation, releasing RPA to localize to chromatin and enable ATR activation. HNRNPA2B1 also hinders homologous recombination by limiting RPA availability. Co-immunoprecipitation, SUMO-interaction motif mapping, RPA chromatin localization assays, ATR activation measurements, HR repair assays, PARP inhibitor sensitivity Molecular Cell High 36702126
2020 hnRNPA2 RRMs bind the A2RE RNA sequence weakly, with both RRMs contributing to binding; addition of A2RE RNA or longer RNAs containing this sequence completely prevents in vitro phase separation of full-length hnRNPA2 and aggregation of disease-associated mutants, suggesting that RNA binding antagonizes granule nucleation. Solution NMR spectroscopy, biophysical binding assays, in vitro phase separation assays with fluorescence microscopy Nucleic Acids Research High 32870271
2016 In Drosophila, disease-homologous mutations in hnRNPA2B1 (Hrb98DE) cause progressive cytoplasmic inclusion pathology in muscle; inclusions contain hnRNPA2B1 associated with stress granule marker ROX8, additional RBPs, and TDP-43. Overexpression of MRJ (DNAJB6 ortholog) rescues inclusion formation, while MRJ loss-of-function enhances it, establishing genetic interaction between hnRNPA2B1 and DNAJB6 disease pathways. Drosophila genetic model, disease-homologous mutagenesis, immunofluorescence for inclusion markers, MRJ overexpression/loss-of-function epistasis Human Molecular Genetics High 26744327
2010 During mitochondrial respiratory stress, Akt1 phosphorylates hnRNPA2, which is required for its recruitment as a transcriptional coactivator to stress-responsive nuclear gene promoters (e.g., Cathepsin L, RyR1, Glut4, Akt1). This phosphorylation step is necessary for functional synergy with NFκB (cRel:p50), C/EBPδ, CREB, and NFAT at these promoters. In vitro kinase assay, promoter ChIP assay, siRNA knockdown, C2C12 cell mitochondrial stress model Biochimica et Biophysica Acta Medium 20153290
2011 In pancreatic cancer cells, hnRNPA2B1 binds Bcl-x mRNA and promotes splicing toward the anti-apoptotic Bcl-xL isoform; its expression is regulated by Fyn kinase activity. Fyn deactivation also reduces Sam68 phosphorylation, altering Sam68-Bcl-x mRNA binding. hnRNPA2B1 and Sam68 coordinately regulate apoptosis downstream of Fyn. RNA immunoprecipitation (RIP), RT-PCR splicing assay, kinase-dead Fyn expression, RNAi knockdown, apoptosis assays Carcinogenesis Medium 21642356
2014 HNRNPA2B1 interacts with oncogenic KRAS G12V/G12D in KRAS-dependent PDAC cells, as shown by mass spectrometry and co-immunoprecipitation. This interaction requires KRAS phosphorylation at serine 181. HNRNPA2B1 knockdown inactivates AKT-mTOR signaling, reduces KRAS interaction with PI3K, and impairs PDAC cell survival and xenograft tumor formation. Mass spectrometry, co-immunoprecipitation, Phos-tag KRAS phosphorylation analysis, shRNA knockdown, xenograft assay Gastroenterology Medium 24998203
2015 hnRNPA2/B1 binds the COX-2 core promoter and activates COX-2 transcription in NSCLC cells. This activation requires cooperation with the transcriptional coactivator p300; hnRNPA2/B1 interacts directly with p300 and is acetylated by p300. Overexpression of p300, but not its HAT-domain deletion mutant, enhances hnRNPA2/B1 acetylation and its binding to the COX-2 promoter. Chromatin immunoprecipitation (ChIP), co-immunoprecipitation, acetylation assay, shRNA/siRNA knockdown, overexpression, in vivo xenograft Molecular Oncology Medium 26774881
2019 hnRNPA2B1 is translationally regulated by M1 muscarinic receptor signaling downstream of cholinergic tone; decreased cholinergic activity reduces hnRNPA2B1 protein levels through nonsense-mediated decay regulation of translation without altering mRNA levels. Knockout mouse experiments confirmed M1 muscarinic receptors are critical for this regulation. Genetic mouse models (cholinergic neuron-specific), in vivo and in vitro pharmacology, polysome/translation assays, knockout validation Journal of Neuroscience Medium 27277805
2016 lnc-HC physically interacts with hnRNPA2B1, and the resulting complex binds Cyp7a1 and Abca1 mRNAs to decrease their expression, thereby negatively regulating hepatocyte cholesterol metabolism. lnc-HC knockdown recovers cholesterol balance in vivo. RNA pulldown, RIP, co-immunoprecipitation, in vivo knockdown model Hepatology Medium 26663205
2020 In HSV-1-infected cells, hnRNPA2B1 is quantitatively translocated from the nucleus to the cytoplasm and co-localizes with a Golgi marker. Knockout of hnRNPA2B1 reduces exosome accumulation 3-fold and reduces HSV-1 apical release >10-fold, while basolateral cell-to-cell spread is unaffected, establishing hnRNPA2B1 as required for Golgi-dependent apical virus egress. hnRNPA2B1 knockout cells, immunofluorescence localization, exosome quantification, viral yield measurements, fractionation Journal of Virology Medium 32295924
2024 hnRNPA2B1 represses the disassembly of arsenite-induced stress granules (SGs) via the ubiquitination-proteasome system. It interacts with core SG proteins G3BP1, G3BP2, USP10, and Caprin-1; depletion of hnRNPA2B1 reduces the G3BP1-USP10/Caprin-1 interaction and elevates G3BP1 ubiquitination, thereby accelerating SG disassembly. Knockout of hnRNPA2B1 in mice causes Sertoli cell-only syndrome and complete male infertility. Co-immunoprecipitation, ubiquitination assays, live-cell SG disassembly imaging, hnRNPA2B1 knockout mice, testis histology Cell Reports Medium 38363675
2024 ISGylation of hnRNPA2B1 (mediated by ISG15/PCAT6 scaffold in breast cancer) protects it from ubiquitin-mediated proteasomal degradation; ISGylated hnRNPA2B1 selectively mediates nuclear export of m6A-tagged mRNAs via the ALYREF/NXF1 export complex, promoting stemness-related gene expression. Co-immunoprecipitation, ISGylation assay, nuclear export assays, RNA immunoprecipitation, ALYREF/NXF1 complex characterization, knockdown/rescue experiments Advanced Science Medium 38626369
2020 ISGylation of hnRNPA2B1 (by ISG15) blocks its recruitment to the 5'UTR of ABCC2 mRNA, thereby suppressing ABCC2 translation and enhancing cisplatin sensitivity in ovarian cancer cells. RNA immunoprecipitation, ISGylation assay, translation assay, siRNA knockdown Biochimica et Biophysica Acta - Molecular Cell Research Medium 31926942
2022 In PAH pulmonary arterial smooth muscle cells, HNRNPA2B1 expression and nuclear localization are increased. RNA immunoprecipitation identified three binding motifs; A2B1 promotes expression of target mRNAs carrying these motifs in a non-redundant manner across cell cycle regulation. A2B1 silencing decreases proliferation and apoptosis resistance; in vivo A2B1 inhibition rescues pulmonary hypertension in rats. RNA immunoprecipitation, RNA sequencing, A2B1 silencing, monocrotaline rat model of pulmonary hypertension, bioinformatics Circulation Medium 35993245
2019 MO-460 (a moracin-O analog) targets hnRNPA2B1 by binding to its C-terminal glycine-rich domain, inhibiting hnRNPA2B1 binding to the 3'-UTR of HIF-1α mRNA and suppressing HIF-1α translation initiation under hypoxic conditions, leading to stress granule accumulation. Chemical proteomics target identification, domain mapping, RNA pulldown, translation assay, stress granule imaging Experimental & Molecular Medicine Medium 30755586
2022 HNRNPA2B1 mediates processing of primary miRNAs (including miR-92a-2-5p and miR-373-3p) in myeloma cells through interaction with DGCR8 (Microprocessor complex), and these miRNAs are packaged into exosomes. Exosomal delivery to monocytes activates osteoclastogenesis (via IRF8 suppression) and suppresses osteoblastogenesis (via RUNX2 suppression), causing bone lesions. RNA pulldown, RIP, co-immunoprecipitation (HNRNPA2B1-DGCR8), exosome isolation, miRNA luciferase assay, in vivo bone histomorphometry Theranostics Medium 36451863
2022 hnRNPA2B1 interacts with HNRNPA2B1 (680-890 nt RRM2 domain) through Linc01232, which prevents ubiquitin-mediated degradation of HNRNPA2B1. Stabilized HNRNPA2B1 then promotes alternative splicing of A-Raf, activating the MAPK/ERK signaling pathway in pancreatic cancer. RNA pulldown, RIP assay, domain mapping, RNA sequencing, ubiquitination assay, MAPK pathway analysis Cancer Letters Medium 32814086
2020 hnRNPA2B1 enhances Lin28B mRNA stability by direct binding, and this mechanism supports ovarian cancer malignant phenotype. Knockdown of hnRNPA2B1 reduces Lin28B expression, and Lin28B re-expression rescues the phenotype of hnRNPA2B1 knockdown. RNA immunoprecipitation, mRNA stability assay, siRNA knockdown, rescue experiment, in vivo xenograft Cancer Letters Medium 32006618
2020 CRNDE maintains hnRNPA2B1 protein stability by inhibiting TRIM21-mediated K63 ubiquitination-dependent degradation. The CRNDE/hnRNPA2B1 axis then facilitates nuclear export and translation of KRAS mRNA, specifically activating MAPK signaling in colorectal cancer. Co-immunoprecipitation, ubiquitination assay, nuclear export assay, polysome profiling, MAPK pathway analysis, knockdown/rescue Cell Death & Disease Medium 37716979
2023 CSNK1D phosphorylates HNRNPA2B1 to enhance its stability. Stabilized HNRNPA2B1 promotes processing of pri-miR-25/93 to mature miR-25-3p/miR-93-5p via m6A-dependent recognition, which in turn targets BAMBI and FOXO3 to activate TGF-β and suppress FOXO pathways in prostate cancer. Mass spectrometry identification of CSNK1D, in vitro kinase assay, m6A-RIP for pri-miRNA recognition, functional miRNA maturation assay Cellular and Molecular Life Sciences Medium 37208565
2013 PARP1 and HNRNPA2B1 specifically bind DNA sequences at the termini of 'forum domains'—50-250 kb chromosomal domains delimited by DNA double-strand break hot spots—that contain coordinately expressed gene clusters, suggesting a role for HNRNPA2B1 in chromosomal domain organization and coordinate gene regulation. Genome-wide DSB mapping, chromatin immunoprecipitation (ChIP) for HNRNPA2B1 binding at domain termini, bioinformatics PLoS Genetics Low 23593027
2022 A hnRNPA2B1 agonist compound PAC5 binds to a pocket near Asp49 in the RNA recognition motif of hnRNPA2B1, activating it and inducing cytoplasmic translocation, where it initiates TBK1-IRF3 pathway and type I IFN production with antiviral activity against HBV and SARS-CoV-2. Chemical biology/binding assays, domain mapping, cytoplasmic translocation assay, IFN production assay, in vivo antiviral models Protein & Cell Medium 36726760
2025 Adenine directly binds and activates hnRNPA2B1 in macrophage nuclei during bacterial infection; adenine-bound hnRNPA2B1 is recruited to Il1b enhancers and increases Il1b enhancer chromatin accessibility by recruiting nucleolin and FTO to mediate Il1b enhancer DNA 6mA demethylation, thereby increasing IL-1β transcription and antibacterial innate immunity. Large-scale metabolite-hnRNPA2B1 interaction screen, binding assay, ChIP for hnRNPA2B1 at Il1b enhancers, ATAC-seq for chromatin accessibility, 6mA methylation assay, myeloid-specific cKO mice Cell Metabolism Medium 39814017
2017 hnRNPA2/B1 mediates IRES-dependent (cap-independent) translation of Sp1 mRNA by being recruited with Nm23-H1 to the 5'UTR of Sp1 mRNA. Nm23-H1 enhances hnRNPA2/B1 protein stability, and this complex promotes internal ribosomal entry site-mediated Sp1 translation in lung cancer cells. RNA immunoprecipitation (5'UTR binding), IRES reporter assay, co-immunoprecipitation (Nm23-H1/hnRNPA2B1), protein stability assay Scientific Reports Medium 28831131
2021 HNRNPA2B1 acts as a trigger of an RNA switch in the 3'UTR of CDK6: it binds a conserved cis-element forming a stem structure near a miR-506 binding site, denatures the stem structure, and recruits RNA helicase DHX9, ultimately facilitating miR-506-mediated CDK6 silencing in lung cancer cells. RNA electrophoretic mobility shift assay (EMSA), RNA secondary structure analysis, RIP, DHX9 recruitment assay, luciferase reporter iScience Low 34805798
2024 In gastric cancer, cytoplasm-anchored hnRNPA2B1 coordinates with poly(A)-binding protein PABPC1 to stabilize its association with cap-binding eIF4F complex, facilitating translation of CIP2A, DLAT, and GPX1 independent of m6A modification. This non-m6A translational function is promoted by H. pylori-induced NF-κB-dependent upregulation of hnRNPA2B1. Mass spectrometry and co-IP for hnRNPA2B1-PABPC1 interaction, Ribo-seq and polysome profiling for translation, RIP-seq, m6A epitranscriptomic microarray Advanced Science Medium 38887155
2022 HNRNPA2B1 promotes mRNA stability of TCF7L2 in an m6A-dependent manner through physical interaction with lncRNA MIR100HG; MIR100HG interaction facilitates hnRNPA2B1 recognition of the m6A site of TCF7L2 mRNA, activating Wnt/β-catenin signaling in colorectal cancer. RNA immunoprecipitation, m6A MeRIP, RNA stability assay, Co-IP, in vitro and in vivo functional assays Molecular Cancer Medium 35279145
2024 DRAIC lncRNA interacts with hnRNPA2B1 and protects it from FBXO11 E3 ligase-mediated ubiquitination and proteasomal degradation. Stabilized hnRNPA2B1 then destabilizes m6A-modified IGF1R mRNA (requiring four specific m6A modification sites) to suppress ccRCC progression. Co-immunoprecipitation, ubiquitination assay, m6A site mapping (MeRIP), mRNA stability assay, FBXO11 E3 ligase identification Oncogene Medium 38811846
2022 Neddylation post-translationally regulates hnRNPA2B1 protein level (without affecting mRNA). hnRNPA2B1 regulates fatty acid oxidation by binding MTPα mRNA (RNA immunoprecipitation). Restoration of hnRNPA2B1 via neddylation inhibitor MLN4924 protects against hypertriglyceridemia-induced pancreatitis. RNA immunoprecipitation for MTPα mRNA, neddylation inhibitor MLN4924, in vivo hyperlipidemic mouse model, NF-κB activation assay Cell Death & Disease Low 36220838
2017 HNRNPA2B1 mediates exclusion of cassette exon 11 from MST1R (RON) pre-mRNA, generating the RON∆165 isoform which activates Akt/PKB signaling, promoting EMT in head and neck cancer. MST1R-minigene model validated this direct splicing role. CRISPR/Cas9 HNRNPA2B1 knockout, MST1R-minigene alternative splicing assay, Akt/PKB signaling readout, EMT markers Laboratory Investigation Medium 32669614

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events. Cell 1262 26321680
2013 Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature 1215 23455423
2019 Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. Science (New York, N.Y.) 300 31320558
2015 The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei. Cell 244 26544936
2022 Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression. Molecular cancer 154 35279145
2021 Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Molecular cell 153 34453888
2021 HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA. Journal of hematology & oncology 127 33794982
2020 Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1. Journal of experimental & clinical cancer research : CR 115 32698890
2003 Transgenes encompassing dual-promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing. Genomics 109 12906852
2016 A novel long noncoding RNA Lnc-HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism. Hepatology (Baltimore, Md.) 107 26663205
2020 m6A Reader HNRNPA2B1 Promotes Esophageal Cancer Progression via Up-Regulation of ACLY and ACC1. Frontiers in oncology 94 33134163
2020 CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nature communications 87 32796831
2019 HNRNPA2/B1 is upregulated in endocrine-resistant LCC9 breast cancer cells and alters the miRNA transcriptome when overexpressed in MCF-7 cells. Scientific reports 86 31263129
1995 Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1. Genomics 83 7789969
2020 Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis. Molecular therapy : the journal of the American Society of Gene Therapy 82 32246902
2011 Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer. Carcinogenesis 68 21642356
2020 Linc01232 promotes the metastasis of pancreatic cancer by suppressing the ubiquitin-mediated degradation of HNRNPA2B1 and activating the A-Raf-induced MAPK/ERK signaling pathway. Cancer letters 65 32814086
2020 Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Cancer letters 59 32006618
2017 HNRNPA2B1 regulates the epithelial-mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway. Cancer cell international 59 28077929
2020 Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration. The EMBO journal 57 33349959
2014 Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells. Gastroenterology 56 24998203
2019 Functional roles of hnRNPA2/B1 regulated by METTL3 in mammalian embryonic development. Scientific reports 55 31201338
2017 Splicing factor hnRNPA2B1 contributes to tumorigenic potential of breast cancer cells through STAT3 and ERK1/2 signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 54 28351333
2023 HNRNPA2B1-mediated m6A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis. Journal of translational medicine 53 37308993
2024 N6-methyladenosine reader hnRNPA2B1 recognizes and stabilizes NEAT1 to confer chemoresistance in gastric cancer. Cancer communications (London, England) 52 38512764
2007 Correlation of DNA methylation with histone modifications across the HNRPA2B1-CBX3 ubiquitously-acting chromatin open element (UCOE). Epigenetics 50 18032920
2001 Expression of early lung cancer detection marker: hnRNP-A2/B1 and its relation to microsatellite alteration in non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands) 47 11714531
2013 Disease mutations in the prion-like domains of hnRNPA1 and hnRNPA2/B1 introduce potent steric zippers that drive excess RNP granule assembly. Rare diseases (Austin, Tex.) 46 25002999
2018 Structural characterization of the D290V mutation site in hnRNPA2 low-complexity-domain polymers. Proceedings of the National Academy of Sciences of the United States of America 45 30279180
2010 Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets. Biochimica et biophysica acta 44 20153290
2021 HNRNPA2B1 regulates tamoxifen- and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells. Cancer letters 43 34273466
2007 The rheumatoid arthritis-associated autoantigen hnRNP-A2 (RA33) is a major stimulator of autoimmunity in rats with pristane-induced arthritis. Journal of immunology (Baltimore, Md. : 1950) 43 18025202
2021 HNRNPA2B1, as a m6A Reader, Promotes Tumorigenesis and Metastasis of Oral Squamous Cell Carcinoma. Frontiers in oncology 42 34631545
2013 hnRNPA2B1 and hnRNPA1 mutations are rare in patients with "multisystem proteinopathy" and frontotemporal lobar degeneration phenotypes. Neurobiology of aging 42 24119545
2015 hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers. Molecular oncology 39 26774881
2019 LncRNA SOX2-OT regulates proliferation and metastasis of nasopharyngeal carcinoma cells through miR-146b-5p/HNRNPA2B1 pathway. Journal of cellular biochemistry 38 31099048
2022 HNRNPA2B1: RNA-Binding Protein That Orchestrates Smooth Muscle Cell Phenotype in Pulmonary Arterial Hypertension. Circulation 37 35993245
2021 hnRNPA2B1 Promotes Colon Cancer Progression via the MAPK Pathway. Frontiers in genetics 37 34630502
2020 Increased expression of YTHDF1 and HNRNPA2B1 as potent biomarkers for melanoma: a systematic analysis. Cancer cell international 37 32549786
2022 Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy. Nature communications 36 35484142
2018 The SH3 domain of Fyn kinase interacts with and induces liquid-liquid phase separation of the low-complexity domain of hnRNPA2. The Journal of biological chemistry 35 30397184
2024 HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 34 38626369
2022 HNRNPA2B1 inhibited SFRP2 and activated Wnt-β/catenin via m6A-mediated miR-106b-5p processing to aggravate stemness in lung adenocarcinoma. Pathology, research and practice 33 35364458
2023 Mutant p53 activates hnRNPA2B1-AGAP1-mediated exosome formation to promote esophageal squamous cell carcinoma progression. Cancer letters 32 37030635
2020 ISG15 suppresses translation of ABCC2 via ISGylation of hnRNPA2B1 and enhances drug sensitivity in cisplatin resistant ovarian cancer cells. Biochimica et biophysica acta. Molecular cell research 31 31926942
2017 Effects of Mutations on the Aggregation Propensity of the Human Prion-Like Protein hnRNPA2B1. Molecular and cellular biology 31 28137911
2017 LncRNA-uc002mbe.2 Interacting with hnRNPA2B1 Mediates AKT Deactivation and p21 Up-Regulation Induced by Trichostatin in Liver Cancer Cells. Frontiers in pharmacology 31 28993733
2022 HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma. Journal of translational medicine 30 36401285
2020 hnRNPA2B1 Associated with Recruitment of RNA into Exosomes Plays a Key Role in Herpes Simplex Virus 1 Release from Infected Cells. Journal of virology 29 32295924
2020 The HNRNPA2B1-MST1R-Akt axis contributes to epithelial-to-mesenchymal transition in head and neck cancer. Laboratory investigation; a journal of technical methods and pathology 29 32669614
2019 Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition. Experimental & molecular medicine 29 30755586
2011 Identification of HnRNP-A2/B1 as a target antigen of anti-endothelial cell IgA antibody in Behçet's disease. The Journal of investigative dermatology 29 22205302
2024 Cholesterol homeostasis confers glioma malignancy triggered by hnRNPA2B1-dependent regulation of SREBP2 and LDLR. Neuro-oncology 28 38070488
2024 hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility. Cell reports 28 38363675
2023 Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. Signal transduction and targeted therapy 28 36658134
2022 m6A reader hnRNPA2B1 drives multiple myeloma osteolytic bone disease. Theranostics 28 36451863
2016 Cholinergic Regulation of hnRNPA2/B1 Translation by M1 Muscarinic Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 28 27277805
2014 Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer. Molecular bioSystems 28 25483567
2013 DNA double-strand breaks coupled with PARP1 and HNRNPA2B1 binding sites flank coordinately expressed domains in human chromosomes. PLoS genetics 28 23593027
2023 Intervening in hnRNPA2B1-mediated exosomal transfer of tumor-suppressive miR-184-3p for tumor microenvironment regulation and cancer therapy. Journal of nanobiotechnology 27 37957722
2021 Endoplasmic reticulum stress promotes sorafenib resistance via miR-188-5p/hnRNPA2B1-mediated upregulation of PKM2 in hepatocellular carcinoma. Molecular therapy. Nucleic acids 27 34786210
2017 Familial Early-Onset Paget's Disease of Bone Associated with a Novel hnRNPA2B1 Mutation. Calcified tissue international 27 28389692
2017 Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis. Neuro-degenerative diseases 27 29131108
2010 BRCA1 modulates the expression of hnRNPA2B1 and KHSRP. Cell cycle (Georgetown, Tex.) 27 21099359
2023 SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses. Molecular cell 26 36702126
2016 Genetic interaction of hnRNPA2B1 and DNAJB6 in a Drosophila model of multisystem proteinopathy. Human molecular genetics 26 26744327
2014 No mutations in hnRNPA1 and hnRNPA2B1 in Dutch patients with amyotrophic lateral sclerosis, frontotemporal dementia, and inclusion body myopathy. Neurobiology of aging 24 24612671
2009 Overexpression of hnRNPA2/B1 in bronchoscopic specimens: a potential early detection marker in lung cancer. Anticancer research 24 19414390
2011 Aberrant expression and localization of hnRNP-A2/B1 is a common event in human gastric adenocarcinoma. Journal of gastroenterology and hepatology 23 21175803
2020 Effect of hnRNPA2/B1 on the proliferation and apoptosis of glioma U251 cells via the regulation of AKT and STAT3 pathways. Bioscience reports 22 32463472
2023 HNRNPA2B1-mediated m6A modification of FOXM1 promotes drug resistance and inhibits ferroptosis in endometrial cancer via regulation of LCN2. Functional & integrative genomics 21 38091112
2021 Enzalutamide-Induced Upregulation of PCAT6 Promotes Prostate Cancer Neuroendocrine Differentiation by Regulating miR-326/HNRNPA2B1 Axis. Frontiers in oncology 21 34277403
2023 hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner. Journal of translational medicine 20 38017546
2021 Exosomal Transfer of miR-185 Is Controlled by hnRNPA2B1 and Impairs Re-endothelialization After Vascular Injury. Frontiers in cell and developmental biology 20 33959603
2023 Identification of a novel heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) ligand that disrupts HnRNPA2B1/nucleic acid interactions to inhibit the MDMX-p53 axis in gastric cancer. Pharmacological research 19 36791898
2022 A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicron in vivo. Protein & cell 19 36726760
2021 lncRNA PCAT6 facilitates cell proliferation and invasion via regulating the miR-326/hnRNPA2B1 axis in liver cancer. Oncology letters 19 33907581
2024 Helicobacter Pylori-Enhanced hnRNPA2B1 Coordinates with PABPC1 to Promote Non-m6A Translation and Gastric Cancer Progression. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 18 38887155
2023 NUF2 promotes tumorigenesis by interacting with HNRNPA2B1 via PI3K/AKT/mTOR pathway in ovarian cancer. Journal of ovarian research 18 36670423
2023 CSNK1D-mediated phosphorylation of HNRNPA2B1 induces miR-25-3p/miR-93-5p maturation to promote prostate cancer cell proliferation and migration through m6A-dependent manner. Cellular and molecular life sciences : CMLS 18 37208565
2023 Activation of the HNRNPA2B1/miR-93-5p/FRMD6 axis facilitates prostate cancer progression in an m6A-dependent manner. Journal of Cancer 18 37215455
2021 lncRNA ST3GAL6‑AS1 promotes invasion by inhibiting hnRNPA2B1‑mediated ST3GAL6 expression in multiple myeloma. International journal of oncology 18 33649796
2020 Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid-liquid phase separation and aggregation. Nucleic acids research 18 32870271
2020 Apoptosis in Cancer Cells Is Induced by Alternative Splicing of hnRNPA2/B1 Through Splicing of Bcl-x, a Mechanism that Can Be Stimulated by an Extract of the South African Medicinal Plant, Cotyledon orbiculata. Frontiers in oncology 17 33163396
2021 The RNA N6 -methyladenosine modulator HNRNPA2B1 is involved in the development of non-small cell lung cancer. Clinical and experimental pharmacology & physiology 16 34717005
2021 HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6. iScience 16 34805798
2020 The novel long noncoding RNA Lnc19959.2 modulates triglyceride metabolism-associated genes through the interaction with Purb and hnRNPA2B1. Molecular metabolism 16 32302712
2022 Identification of miR-30c-5p as a tumor suppressor by targeting the m6 A reader HNRNPA2B1 in ovarian cancer. Cancer medicine 15 36259156
2017 Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression. Scientific reports 15 28831131
2023 HnRNPA2B1 Aggravates Inflammation by Promoting M1 Macrophage Polarization. Nutrients 14 37049395
2023 CRNDE mediated hnRNPA2B1 stability facilitates nuclear export and translation of KRAS in colorectal cancer. Cell death & disease 14 37716979
2021 HnRNPA2B1 promotes the proliferation of breast cancer MCF-7 cells via the STAT3 pathway. Journal of cellular biochemistry 14 33399232
2021 LncRNA AC105942.1 Downregulates hnRNPA2/B1 to Attenuate Vascular Smooth Muscle Cells Proliferation. DNA and cell biology 14 33781092
2025 Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity. Cell metabolism 13 39814017
2022 Neddylation-mediated degradation of hnRNPA2B1 contributes to hypertriglyceridemia pancreatitis. Cell death & disease 13 36220838
2021 Transthyretin affects the proliferation and migration of human retinal microvascular endothelial cells in hyperglycemia via hnRNPA2B1. Biochemical and biophysical research communications 13 33894415
2020 Identification of anti-tumoral feedback loop between VHLα and hnRNPA2B1 in renal cancer. Cell death & disease 13 32826868
2024 DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression. Oncogene 12 38811846
2015 Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin. ACS chemical neuroscience 12 26030368
2024 LSD1 modulates the bone metastasis of breast cancer cells through hnRNPA2B1-mediated sorting of exosomal miRNAs. Cell death discovery 11 38448424