Affinage

FYN

Tyrosine-protein kinase Fyn · UniProt P06241

Length
537 aa
Mass
60.8 kDa
Annotated
2026-06-09
100 papers in source corpus 48 papers cited in narrative 48 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FYN is a dually acylated Src-family non-receptor tyrosine kinase that is targeted to plasma-membrane lipid-raft/caveolar microdomains by sequential N-myristoylation on cytosolic polysomes and subsequent palmitoylation, where these microdomains constitute a suppressive microenvironment that keeps the kinase inactive until receptor engagement (PMID:9839441, PMID:30588803). Its catalytic output is set by phospho-regulation of its activating and inhibitory tyrosines: PTPα dephosphorylates raft-associated FYN to control its activity and couple it to the Cbp/PAG–Csk axis (PMID:16339530), and this PTPα→FYN module is itself gated by STEP, which is relieved upon ethanol-driven PKA signaling to allow FYN-dependent upregulation of GluN2B NMDA-receptor signaling (PMID:25951993). Acting downstream of a broad range of receptors—the TCR, FcεRI, integrins, RTKs (Trk, TrkB, Tyro3, FLT3), GPCRs, TLR4 and P2X7—FYN transduces signals to cytoskeletal, adhesion, and transcriptional effectors (PMID:11005864, PMID:12089510, PMID:12917446, PMID:16860569, PMID:25106729). In the nervous system FYN is the principal kinase (with Src) phosphorylating the Reelin adaptor Dab1 to direct neuronal migration (PMID:12526739, PMID:16162939), drives myelination through TrkB/Erk and DCC/N-WASP/RhoA pathways in oligodendrocytes (PMID:26449489, PMID:19141671), and is a central node in neurodegeneration, mediating Aβ-oligomer signaling through Pyk2 to NR2B and controlling tau hyperphosphorylation and aggregation in vivo (PMID:25707991, PMID:29782321, PMID:32814048). In immune cells FYN phosphorylates Vav to build the immunologic synapse (PMID:11005864) and inactivates SHP-1 at Ser591 to switch ITAM signaling toward activation, opposing Lyn (PMID:28811476). FYN phosphorylates a defined substrate set—Nephrin (slit-diaphragm integrity) (PMID:12668668, PMID:15579503), flotillin-1/2 Tyr160/163 (raft endocytosis) (PMID:19258392), p130Cas (rigidity sensing) (PMID:16597701), NOX4 Tyr566 (negative ROS regulation in cardiomyocytes) (PMID:27525436), β-catenin Tyr142 (osteoarthritic cartilage degradation) (PMID:29555825), and APP Tyr757 (PMID:18089558)—coupling membrane microdomain organization to cytoskeletal remodeling, cell adhesion, and transcriptional programs. FYN dysregulation is oncogenic: the recurrent FYN-TRAF3IP2 fusion drives NF-κB-dependent T-cell lymphoma (PMID:33928261).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1995 High

    Establishing that FYN occupies a distinct node in adhesion and cytoskeletal signaling addressed whether Src-family kinases are functionally redundant; genetic dissection showed FYN and Src have overlapping but separable substrate preferences.

    Evidence Genetic epistasis in src/fyn/csk mutant mouse embryos with phospho-substrate biochemistry, plus fyn-null keratinocyte differentiation assays

    PMID:7557381 PMID:7617039

    Open questions at the time
    • Did not resolve how membrane localization dictates the substrate split between FYN and Src
    • Cortactin phosphorylation attribution remained partly shared
  2. 1998 Medium

    Defining how FYN reaches its site of action answered where its activity is spatially constrained; dual acylation was shown to cluster FYN in caveolae-like microdomains.

    Evidence Biochemical acylation and membrane-fractionation analysis (review with primary data), plus fyn-/- requirement in CD73 GPI-anchored signaling

    PMID:9808167 PMID:9839441

    Open questions at the time
    • Acylation evidence from a review rather than a primary structural study
    • How palmitoylation dynamically partitions FYN between active and suppressive pools not addressed
  3. 1999 High

    Demonstrating FYN-specific (not Src-redundant) signaling answered whether individual SFKs run dedicated pathways; FYN was shown to be uniquely required for H2O2-induced JAK2/Shc/Ras activation.

    Evidence Fyn-/- vs Src-/- fibroblasts with isogenic FYN-but-not-Src rescue of JAK2 activation

    PMID:10409649

    Open questions at the time
    • Direct FYN substrate in the ROS→JAK2 step not identified
    • Mechanism of redox activation of FYN unresolved
  4. 2000 High

    Identifying upstream activators answered how FYN is switched on in epithelia and lymphocytes; PKC-eta was shown to directly bind and activate FYN, and antagonist-TCR signaling to selectively engage FYN→Vav.

    Evidence In vitro kinase reconstitution with recombinant PKC-eta and co-IP; Fyn-/- TCR-transgenic T cells with Vav phosphorylation and conjugate-formation readouts

    PMID:11005864 PMID:11106751

    Open questions at the time
    • Structural basis of PKC-eta/FYN activation not defined
    • How antagonist peptides bias toward FYN over Lck mechanistically unresolved
  5. 2003 High

    Linking FYN to receptor-specific developmental and barrier substrates answered which physiological pathways depend on it; FYN was shown to be the dominant Dab1 kinase in Reelin signaling and a direct Nephrin SH3-binding kinase in podocytes.

    Evidence Pharmacological/genetic SFK dissection of Dab1 phosphorylation in fyn/src/yes embryos; SH3 pulldown, in vitro kinase assay, and Fyn-KO podocyte ultrastructure

    PMID:12526739 PMID:12668668 PMID:15579503 PMID:16162939

    Open questions at the time
    • Direct Dab1 phosphosite stoichiometry in vivo only partially quantified
    • Whether Nephrin and Dab1 share FYN regulatory inputs unknown
  6. 2006 Medium

    Defining how membrane targeting confers function answered why FYN, not Src, supports rigidity sensing and caveolar entry; the palmitoylation site was shown to be necessary and sufficient to confer the FYN-specific rigidity response, and FYN was required for caveolar virus uptake.

    Evidence Palmitoylation-site Src chimeras with live imaging of p130Cas phosphorylation; inhibitor/siRNA/caveolar transport assays for coxsackievirus entry

    PMID:16413486 PMID:16597701

    Open questions at the time
    • Single-lab imaging for the rigidity-response chimera
    • How leading-edge FYN couples mechanical force to kinase activation unresolved
  7. 2005 High

    Resolving how FYN catalytic output is set answered the phosphatase control logic; PTPα was shown to govern raft FYN activity via its activating/inhibitory tyrosines and the Cbp/PAG–Csk circuit.

    Evidence PTPα-knockout thymocytes with lipid-raft fractionation, phospho-specific FYN Tyr antibodies, and Cbp/PAG-Csk co-IP

    PMID:16339530

    Open questions at the time
    • Net activity outcome of simultaneous Tyr417/Tyr528 changes not fully reconciled
    • Tissue-specificity of PTPα-FYN coupling not addressed
  8. 2009 High

    Defining FYN endocytic substrates answered how it remodels raft membrane traffic; FYN was shown to directly phosphorylate flotillin-1 Tyr160 and flotillin-2 Tyr163 to drive internalization.

    Evidence SYF null-cell reconstitution, inducible FYN activation, Y→F mutagenesis, and GPI-protein endocytosis readout

    PMID:19258392

    Open questions at the time
    • Cargo selectivity of flotillin-mediated endocytosis downstream of FYN not delineated
  9. 2015 High

    Establishing FYN as a druggable hub in Alzheimer signaling answered whether targeting it reverses pathology; FYN inhibition blocked Aβ→Pyk2→NR2B signaling and rescued memory and synapses, and STEP was shown to gate the PTPα→FYN→GluN2B axis.

    Evidence AZD0530 in APP/PS1 and triple-transgenic mice with behavioral/biochemical readouts; STEP knockdown, in vitro phosphatase assay, and synaptosomal fractionation

    PMID:25707991 PMID:25951993 PMID:29782321

    Open questions at the time
    • Direct vs indirect contribution of FYN-Pyk2 to NR2B phosphorylation partly inferential
    • Pyk2-as-tau-kinase placement downstream of FYN is Medium-confidence single-lab
  10. 2016 High

    Identifying organ-specific substrates answered how FYN drives disease in heart and joint; FYN directly phosphorylates NOX4 Tyr566 to restrain ROS and β-catenin Tyr142 to accelerate osteoarthritis.

    Evidence Co-IP, site-directed mutagenesis, in vitro kinase assays, and Fyn-KO (with Nox4-KO rescue / DMM OA) mouse models

    PMID:27525436 PMID:28811476 PMID:29555825

    Open questions at the time
    • Whether NOX4 and β-catenin phosphorylation share an upstream receptor trigger unknown
    • FYN/Lyn SHP-1 phospho-switch generality across receptors not fully mapped
  11. 2020 High

    Separating FYN's tau role from amyloid answered whether FYN acts on tauopathy independently of Aβ; FYN knockout nearly abolished neurofibrillary tangles and reduced tau seeding, and α-synuclein/inflammasome work extended FYN to broader neurodegeneration.

    Evidence Fyn-KO crossed to tau-transgenic mice, tau seeding biosensor, phosphomimetic Y18E fibrillization; Fyn-KO α-synuclein PD models with NLRP3/NF-κB readouts

    PMID:31036561 PMID:32814048

    Open questions at the time
    • Whether direct tau Y18 phosphorylation vs Pyk2-mediated phosphorylation dominates in vivo unresolved
    • Relative contribution of microglial vs neuronal FYN to tau spread not separated
  12. 2021 High

    Defining oncogenic FYN dysregulation answered how it transforms T cells; the FYN-TRAF3IP2 fusion was shown to drive NF-κB-dependent lymphoma sensitive to IKK inhibition.

    Evidence Fusion identification by sequencing, hematopoietic progenitor reconstitution mouse models, NF-κB assays, and IKK-inhibitor rescue

    PMID:33928261

    Open questions at the time
    • Whether FYN kinase activity per se or TRAF3IP2-mediated scaffolding drives NF-κB not fully dissected
    • Cooperating lesions beyond Tet2 loss not enumerated
  13. 2023 Medium

    Distinguishing FYN from LCK in engineered T cells answered which SFK drives durable CAR-T responses; CD28-CARs were shown to signal through FYN to promote memory while LCK drives exhaustion.

    Evidence LCK-deficient CAR-T cells, CD28 intracellular-domain mutant CARs, and in vivo anti-tumor efficacy/phenotyping

    PMID:36696897

    Open questions at the time
    • Direct FYN substrates underlying the memory program not identified
    • Single-lab in vivo efficacy data

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the suppressive lipid-raft microenvironment, receptor-specific recruitment, and phosphatase gating are integrated to select among FYN's many substrates in a given cell type remains unresolved.
  • No unified model linking membrane microdomain residency to substrate choice
  • Structural basis of FYN activation by diverse receptors lacking
  • Quantitative rules governing FYN vs Src/Lyn substrate partitioning unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 6 GO:0140096 catalytic activity, acting on a protein 6 GO:0060089 molecular transducer activity 4
Localization
GO:0005856 cytoskeleton 4 GO:0005886 plasma membrane 3 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-112316 Neuronal System 4 R-HSA-1643685 Disease 4 R-HSA-168256 Immune System 4 R-HSA-5653656 Vesicle-mediated transport 3
Partners
DCCFLT3NEPHRINNOX4P2X7PIKE-ATLR4TYRO3

Evidence

Reading pass · 48 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 Fyn is required for Reelin-induced tyrosine phosphorylation and downregulation of the adaptor protein Disabled-1 (Dab1) in neurons. Fyn directly phosphorylates Dab1, and genetic reduction of Fyn copy number reduces Dab1 phosphorylation stoichiometry in vivo; Src partially compensates when Fyn is reduced, but Yes does not. Pharmacological Src-family kinase inhibition, analysis of Dab1 phosphorylation in fyn/src/yes mutant mouse embryos, cultured neuron assays Current biology : CB High 12526739
2005 Combined absence of Src and Fyn nearly abolishes Dab1 tyrosine phosphorylation and phenocopies the reeler phenotype (inverted cortical layering, impaired Purkinje plate formation), demonstrating that Src and Fyn are the principal kinases mediating Reelin-dependent neuronal migration in vivo. Double Src/Fyn knockout mice, immunohistochemistry, Dab1 phosphorylation biochemistry The Journal of neuroscience : the official journal of the Society for Neuroscience High 16162939
2002 FcεRI activation of mast cells engages a Fyn kinase-dependent signaling pathway that is distinct from the Lyn/LAT pathway and is specifically required for mast cell degranulation. Fyn deficiency impairs degranulation while leaving the calcium response intact; Lyn deficiency enhances Fyn-dependent signals. Fyn-knockout and Lyn-knockout mast cells, degranulation assays, calcium measurement Nature immunology High 12089510
2003 Fyn directly binds Nephrin via its SH3 domain and phosphorylates Nephrin on tyrosine in podocyte lipid-raft membrane fractions. Genetic deletion of Fyn in mice causes coarsening of podocyte foot processes and markedly reduces Nephrin phosphorylation in glomerular detergent-resistant membrane fractions. Biochemical fractionation, direct binding assays (SH3-domain pulldown), in vitro kinase assay, Fyn/Yes knockout mice, glomerular morphology analysis The Journal of biological chemistry High 12668668
2004 Fyn phosphorylates the cytoplasmic domain of Nephrin on multiple tyrosine residues more potently than Src. This phosphorylation augments the interaction between Nephrin and Podocin and activates AP-1 promoter signaling downstream of Nephrin/Podocin. Co-transfection of Cos-1 cells, tyrosine-to-phenylalanine mutagenesis, co-immunoprecipitation, AP-1 reporter assay Journal of the American Society of Nephrology : JASN High 15579503
2006 Coxsackievirus attachment to DAF on the apical epithelial surface activates Fyn kinase, which is required for phosphorylation of caveolin and transport of the virus into the cell within caveolar vesicles. Inhibitor studies, siRNA, caveolar transport assays in polarized epithelial cells Cell High 16413486
1995 Fyn participates in regulation of focal adhesion kinase (FAK) and paxillin phosphorylation in the cytoskeleton downstream of Csk. Double-mutant genetic analysis shows Fyn and Src have overlapping but distinct roles: Src controls cortactin and tensin phosphorylation, while FAK/paxillin phosphorylation is partly dependent on both. Genetic epistasis in src/fyn/csk triple-mutant mouse embryos, tyrosine phosphorylation biochemistry, immunofluorescence of actin and cortactin Nature High 7617039
1995 Fyn kinase is activated in mouse keratinocytes during calcium- or TPA-induced differentiation, phosphorylates cortactin (p80-85), and is specifically required for keratinocyte differentiation; fyn-null keratinocytes show no p80-85 phosphorylation induction and are impaired in differentiation both in vitro and in vivo. Kinase activity immunoprecipitation assay, fyn/yes knockout keratinocytes, in vitro and in vivo differentiation assays Genes & development High 7557381
1999 Fyn mediates reactive oxygen species (H2O2)-induced activation of JAK2, leading to Shc tyrosine phosphorylation and Ras activation. This pathway is Fyn-specific: H2O2-stimulated JAK2, Shc, and Ras activation are abolished in Fyn-/- fibroblasts but unaltered in Src-/- fibroblasts; re-expression of Fyn (but not Src) rescues JAK2 activation. Fyn-/- and Src-/- fibroblasts, kinase activity assays, Ras-GTP pull-down, rescue by transfection of Fyn vs. Src The Journal of biological chemistry High 10409649
2000 PKC-eta directly associates with Fyn and directly activates Fyn kinase activity in vitro. PKC-eta-driven growth suppression of keratinocytes depends on Fyn, placing Fyn downstream of PKC-eta in the keratinocyte growth-arrest/differentiation pathway. Fyn activation alone suppresses keratinocyte (but not fibroblast) growth by downmodulating EGF receptor signaling. Co-immunoprecipitation of PKC-eta and Fyn, in vitro kinase assay with recombinant PKC-eta, fyn-KO keratinocytes, EGFR signaling analysis Molecular cell High 11106751
2009 Fyn kinase regulates endocytosis of flotillin-1 and flotillin-2: EGF induces flotillin internalization via Fyn (but not Src or Yes) by directly phosphorylating Tyr160 on flotillin-1 and Tyr163 on flotillin-2; mutation of these residues to phenylalanine blocks Fyn-induced flotillin internalization and reduces uptake of the GPI-linked protein CD59. SYF cells (Src/Yes/Fyn-null) with individual kinase re-expression, rapamycin-inducible Fyn activation system, site-directed mutagenesis (Y→F), GPI-protein endocytosis assay Journal of cell science High 19258392
2006 Cell rigidity response on fibronectin requires Fyn (but not endogenous c-Src) at the leading edge. Fyn recruitment depends on its palmitoylation site; adding that palmitoylation site to c-Src enables it to support the rigidity response. Fyn phosphorylates p130Cas at the leading edge in a rigidity-dependent manner. Live-cell imaging of GFP-tagged Src-family kinases, palmitoylation-site chimeras, p130Cas phosphorylation assay at leading edges Molecular biology of the cell Medium 16597701
2003 Integrin αvβ6 ligation by fibronectin in oral squamous cell carcinoma forms a complex with Fyn, activates Fyn kinase, recruits and activates FAK, activates Shc, and couples to the Raf-ERK/MAPK pathway, leading to MMP-3 transcription and promoting cancer cell proliferation and experimental metastasis. Co-immunoprecipitation of β6/Fyn/FAK complex, kinase activity assays, MMP-3 reporter, in vivo metastasis model The Journal of biological chemistry Medium 12917446
2000 TCR antagonist stimulation selectively activates Fyn kinase and induces Vav tyrosine phosphorylation in a Fyn-dependent manner, without activating Lck or ZAP-70. Fyn-deficient T cells fail to phosphorylate/activate Vav and cannot form APC-T cell conjugates (immunologic synapse) in response to either agonist or antagonist peptides. Fyn-/- TCR-transgenic mice, Jurkat cells with differential Lck/Fyn expression, kinase activity assays, Vav phosphorylation, conjugate formation assay Proceedings of the National Academy of Sciences of the United States of America High 11005864
1998 Fyn is N-myristoylated on cytosolic polysomes and then targeted to the plasma membrane where it is palmitoylated. Dual acylation clusters Fyn in caveolae-like membrane microdomains. Biochemical acylation analysis, membrane fractionation, lipid raft/caveolae isolation (review with primary biochemical data cited) The international journal of biochemistry & cell biology Medium 9839441
1998 CD73 ligation-mediated signal transduction in murine T lymphocytes requires Fyn kinase: fyn-/- mice are unresponsive to CD73-mediated signaling, demonstrating a necessary role for Fyn in this GPI-anchored protein signaling pathway. fyn-/- mice, anti-CD73 mAb stimulation, T cell proliferation and IL-2 secretion assays European journal of immunology Medium 9808167
2005 Receptor protein tyrosine phosphatase alpha (PTPα) suppresses Fyn activity in thymocyte lipid rafts. In PTPα-/- thymocytes, raft-associated Fyn is hyperactivated due to increased phosphorylation at its activating (Tyr417) and inhibitory (Tyr528) residues. Hyperactive Fyn then phosphorylates Cbp/PAG, promoting its association with C-terminal Src kinase (Csk). PTPα-knockout thymocytes, lipid raft fractionation, Fyn kinase activity assay, phospho-specific antibodies for Fyn Tyr417/528, Cbp/PAG co-IP with Csk Journal of immunology (Baltimore, Md. : 1950) High 16339530
2015 STEP (STriatal-Enriched protein tyrosine Phosphatase) dephosphorylates PTPα at Tyr789, preventing PTPα translocation to synaptic membranes and blocking its ability to activate Fyn. Upon ethanol exposure, PKA phosphorylates and inactivates STEP, allowing PTPα to translocate to lipid rafts and activate Fyn, which then upregulates GluN2B-containing NMDA receptor signaling. Primary neuronal cultures, STEP knockdown/pharmacological inhibition, phospho-specific antibodies, synaptosomal fractionation, in vitro phosphatase assay, in vivo ethanol treatment Journal of neurochemistry High 25951993
2009 Netrin-1 binding to DCC on mature oligodendrocytes recruits Fyn to a complex with the DCC intracellular domain that includes FAK and N-WASP, resulting in RhoA inhibition and induction of process remodeling. Fyn-/- oligodendrocytes fail to increase process branching in response to netrin-1. Fyn-knockout oligodendrocyte cultures, co-immunoprecipitation of DCC/Fyn/FAK/N-WASP complex, RhoA activity assay, in vitro process branching assay, in vivo netrin-1/DCC expression studies Development (Cambridge, England) High 19141671
2016 FYN interacts with the C-terminal domain of NOX4, colocalizes with NOX4 in perinuclear mitochondria/ER/nuclear fractions in cardiomyocytes, and directly phosphorylates NOX4 at Tyr566 to negatively regulate NOX4-induced superoxide production and apoptosis. FYN-deficient mice show exacerbated cardiac hypertrophy; Nox4 deletion rescues this phenotype. Co-immunoprecipitation, co-localization imaging, site-directed mutagenesis of Tyr566, in vitro kinase assay, Fyn-KO and Nox4-KO mice, transverse aortic constriction model The Journal of clinical investigation High 27525436
2017 Fyn phosphorylates SHP-1 at Ser591 (inactivating the phosphatase), enabling activatory immunoreceptor (ITAM) signaling. By contrast, Lyn phosphorylates SHP-1 at Tyr536 (activating the phosphatase), promoting inhibitory signaling. Thus Fyn and Lyn have opposing roles in controlling immunoreceptor signaling status. Site-specific phosphorylation assays, SHP-1 mutagenesis, Fyn-/- and Lyn-/- mice, nephritis and arthritis in vivo models Nature communications High 28811476
2015 Fyn inhibition (AZD0530) potently inhibits Fyn and prevents Aβ oligomer-induced signaling through Fyn to Pyk2 and NR2B NMDA receptors in brain slices. In APP/PS1 mice, AZD0530 fully rescues spatial memory, synaptic depletion, and reduces microglial activation without affecting Aβ metabolism; it also rescues Tau phosphorylation in APP/PS1/Tau mice. Brain slice signaling assays, pharmacokinetics, Morris water maze, novel object recognition, immunohistochemistry, immunoblotting in APP/PS1 and triple-transgenic mice Annals of neurology High 25707991
2019 Fyn kinase, in conjunction with CD36, regulates microglial uptake of aggregated α-synuclein. Fyn mediates PKCδ-dependent NF-κB-p65 nuclear translocation leading to NLRP3 inflammasome priming, and facilitates αSyn import into microglia to generate mitochondrial ROS that activate the NLRP3 inflammasome. Fyn-KO mice, A53T and viral αSyn overexpression mouse models, siRNA knockdown, NF-κB reporter, NLRP3 inflammasome activation assays, human PD neuropathology The Journal of experimental medicine High 31036561
2018 Fyn directly colocalizes with and phosphorylates β-catenin at Tyr142 in articular chondrocytes, stabilizing β-catenin and promoting its nuclear translocation, thereby upregulating catabolic enzymes and accelerating cartilage degradation and osteoarthritis development. Co-immunoprecipitation, phosphorylation assay with Tyr142 site-specific analysis, Fyn-KO mice with destabilization-of-medial-meniscus OA model, pharmacological Fyn inhibition (AZD0530, PP1) Annals of the rheumatic diseases High 29555825
2020 Fyn kinase controls tau aggregation in vivo independently of Aβ. Fyn-knockout in a mutant-tau transgenic mouse (Tg/Fyn-/-) nearly abolishes neurofibrillary tangles, reduces tau hyperphosphorylation, alters tau solubility, diminishes synaptic tau accumulation, and reduces tau seeding capacity. Pseudophosphorylation of tau at the Fyn epitope Y18 boosts tau fibrillization in vitro. Fyn-KO crossed to tau-transgenic mice, tau seeding biosensor assay, in vitro fibrillization assay with phosphomimetic tau Y18E Cell reports High 32814048
2018 Pyk2 is a novel tau tyrosine kinase that colocalizes, interacts with, and phosphorylates tau in vivo and in vitro. Pyk2 activity is increased in Fyn-constitutively-active mice and decreased in Fyn-KO mice, placing Pyk2 as a direct tau kinase acting downstream of Fyn. Pyk2-transgenic and Pyk2/tau double-transgenic mice, in vitro kinase assay of Pyk2 phosphorylating tau, co-immunoprecipitation, FynCA and FynKO mice Journal of Alzheimer's disease : JAD Medium 29782321
2006 Fyn mediates transactivation of Trk receptor tyrosine kinases by adenosine (a G-protein-coupled receptor ligand). Fyn and Trk colocalize in a juxtanuclear membrane compartment, adenosine activates Fyn, and Fyn directly phosphorylates Trk in vitro with kinetics matching Trk activation in cells. Co-localization imaging, in vitro Fyn phosphorylation of Trk assay, adenosine stimulation time-course, Fyn overexpression rescue Molecular and cellular neurosciences Medium 16860569
2015 BDNF activation of oligodendroglial TrkB receptors stimulates Fyn phosphorylation, which is necessary for subsequent phosphorylation of Erk1/2 and promotion of CNS myelination. A kinase-dead Fyn mutant inhibits BDNF-induced Erk1/2 activation and abrogates BDNF's promyelinating effect. Myelinating cocultures, PP2 inhibitor, kinase-dead Fyn overexpression, Fyn overexpression in oligodendrocytes, in vivo Fyn phosphorylation co-localization with mature oligodendrocytes Glia Medium 26449489
2015 Tyro3 receptor tyrosine kinase binds Fyn via affinity chromatography of the Tyro3 intracellular domain, and Fyn kinase activity is downregulated in Tyro3-KO mice. Fyn-KO mice exhibit reduced myelin thickness and decreased myelination in Schwann cell-neuron cocultures, identifying Tyro3-Fyn as a receptor-linked signaling mechanism controlling Schwann cell myelination. Affinity chromatography to identify Fyn as Tyro3 binding partner, Tyro3-KO and Fyn-KO mice, dorsal root ganglion cocultures, myelin thickness measurement Molecular biology of the cell Medium 26224309
2011 Fyn regulates apoptosis in pancreatic cancer by controlling HnRNPA2B1 and Sam68: Fyn activity maintains HnRNPA2B1 expression (which promotes anti-apoptotic Bcl-xL splicing via blocking Bcl-xS formation) and phosphorylates Sam68 (reducing its pro-Bcl-xL splicing activity). Loss of Fyn kinase activity reduces HnRNPA2B1 and decreases Sam68 phosphorylation, shifting Bcl-x splicing toward the pro-apoptotic Bcl-xS. Kinase-dead Fyn transfection, HnRNPA2B1 siRNA, Sam68 siRNA, Bcl-x splicing assay, apoptosis assays Carcinogenesis Medium 21642356
2011 Fyn mediates hyperosmolarity-induced retrieval of the bile canalicular transporters Mrp2 and Bsep from the canalicular membrane in rat liver. This is driven by NADPH oxidase-generated ROS activating Fyn. Fyn associates with cortactin and increases cortactin phosphorylation beneath the canalicular membrane, contributing to transporter retrieval. Perfused rat liver model, Fyn-specific inhibitor PP-2, Fyn siRNA knockdown, p47phox-KO mice, co-immunoprecipitation of Fyn-cortactin, cortactin phosphorylation assay, biliary excretion measurement The Journal of biological chemistry Medium 22057277
2016 FYN associates with FLT3 (both wild-type and oncogenic FLT3-ITD) via the FYN SH2 domain interacting with multiple FLT3 phosphotyrosine sites in a kinase-activity-dependent manner. FYN expression selectively potentiates FLT3-ITD-dependent STAT5 phosphorylation and colony formation. Co-immunoprecipitation, SH2-domain mutant FYN, FYN overexpression in FLT3-ITD cells, phospho-STAT5/AKT/ERK immunoblotting, colony formation assay Oncotarget Medium 26848862
2012 IFNγ induces Fyn-dependent phosphorylation of E-cadherin and p120-catenin, leading to E-cadherin internalization, ubiquitinylation (via Hakai E3 ligase), and proteasomal degradation. Fyn siRNA or the Src-kinase inhibitor PP1 prevents IFNγ-induced E-cadherin internalization and subsequent epithelial barrier disruption. siRNA knockdown of Fyn, immunoprecipitation, immunofluorescence confocal microscopy, E-cadherin ubiquitinylation assay, barrier integrity assay PloS one Medium 22715382
2016 Fyn deficiency attenuates renal fibrosis through a STAT3-dependent mechanism that is independent of the Smad pathway. STAT3 small interfering RNA in Fyn-deficient cells further suppresses α-SMA expression, and a STAT3 activator partially restores fibrotic markers, placing STAT3 downstream of Fyn in renal fibrogenesis. Fyn-KO mice with unilateral ureteral obstruction, pharmacological Fyn inhibition in kidney cell lines, STAT3 siRNA in Fyn-deficient cells, STAT3 activator rescue Kidney international Medium 27616741
2016 MOBP (myelin-associated oligodendrocytic basic protein) synthesis is stimulated by Fyn kinase activity in cultured primary oligodendrocytes, and MOBP promotes morphological differentiation of oligodendrocytes. Fyn kinase inhibition and activation in primary oligodendrocyte cultures, MOBP expression and morphology analysis Journal of cell science Low 26801084
2015 Fyn-phosphorylated PIKE-A binds to and inhibits AMPK's catalytic alpha subunit, impairing T172 phosphorylation and reducing AMPK kinase activity. Fyn depletion or pharmacological Fyn inhibition prevents PIKE-A/AMPK association, restoring AMPK tumor-suppressive activity. Co-immunoprecipitation of PIKE-A and AMPK, Fyn phosphorylation-site mutagenesis of PIKE-A, Fyn siRNA/inhibitor, AMPK substrate phosphorylation assay, cell proliferation assay, glioblastoma samples Cell death and differentiation Medium 26001218
2013 Fyn regulates adipogenesis by phosphorylating PIKE-A, which then enhances PIKE-A interaction with STAT5a, reducing STAT5a transcriptional activity. Fyn-null or pharmacologically inhibited adipocytes fail to fully differentiate, and PIKE-/- adipose tissue also shows reduced STAT5a activity. 3T3-L1 adipogenesis model, Fyn-KO cells, Fyn pharmacological inhibition, co-IP of PIKE-A/STAT5a, STAT5a transcriptional reporter Molecular and cellular biology Medium 23438599
2008 Lysophosphatidic acid (LPA) induces rapid Fyn activation and increased association of Fyn with p120-catenin at cell-cell junctions in ovarian cancer cells, driving junction dispersal and single-cell migration. This is the principal Src-family kinase recruited to p120-catenin in this context. Co-immunoprecipitation of Fyn and p120-catenin after LPA stimulation, PP2 inhibitor, immunofluorescence of junction dynamics International journal of cancer Low 18506685
2014 TLR4 physically interacts with Fyn upon LPS stimulation in astrocytes (shown by co-immunoprecipitation and co-localization), and this TLR4-Fyn interaction drives PI3K/Akt/NF-κB-dependent upregulation of PAI-1. Fyn siRNA or PP2 blocks TLR4 tyrosine phosphorylation and LPS-induced PAI-1 expression. Co-immunoprecipitation of TLR4-Fyn, immunofluorescence co-localization, Fyn siRNA, PP2 inhibitor, PAI-1 expression assay, neurite outgrowth assay Molecular neurobiology Medium 25106729
2013 Fyn kinase is required for dengue virus RNA replication. RNAi depletion of Fyn reduces DV2 RNA replication, and serial passaging of virus under dasatinib or AZD0530 selects a resistance mutation in the NS4B transmembrane domain 3, genetically linking Fyn to the viral RNA replication step. RNAi depletion of Src-family kinases, Northern blot and reporter replicon assays, resistance mutation mapping by serial passaging Journal of virology Medium 23616652
2021 FYN-TRAF3IP2 is a recurrent oncogenic gene fusion in AITL and PTCL, NOS that drives aberrant NF-κB signaling downstream of T cell receptor activation. Expression of FYN-TRAF3IP2 in hematopoietic progenitors induces NF-κB-driven T cell transformation in mice and cooperates with Tet2 loss in PTCL development; IκB kinase inhibitors suppress FYN-TRAF3IP2-induced lymphoma. Identification of fusion by sequencing, hematopoietic progenitor reconstitution mouse model, NF-κB reporter and signaling assays, IKK inhibitor treatment in vitro and in vivo Nature cancer High 33928261
2018 Fyn is a modulator of erythropoietin signaling: Fyn-/- mice exhibit reduced tyrosine phosphorylation of EPO-R and decreased STAT5 activity. Fyn also acts as a physiologic repressor of Nrf2; absence of Fyn leads to persistent Nrf2 activation, ROS-induced Jak2-Akt-mTOR pathway overactivation, and impaired autophagy, which can be rescued by rapamycin. Fyn-/- mice, EPO-R tyrosine phosphorylation assay, STAT5 activity, Nrf2 target gene expression, mTOR pathway immunoblotting, rapamycin treatment American journal of hematology Medium 30252956
2019 Aβ oligomers promote oligodendrocyte differentiation and MBP translation via integrin β1 receptor and Fyn kinase, with Ca2+/CaMKII as downstream effectors. Pharmacological Fyn inhibition attenuates Aβ-induced oligodendrocyte differentiation and MBP upregulation in organotypic cerebellar slices. Integrin β1 blockade, Fyn pharmacological inhibition, MBP local translation assay, organotypic cerebellar slice model with lysolecithin demyelination Cell death & disease Medium 31171765
2015 P2X7 receptor physically interacts with Fyn kinase (co-immunoprecipitation), and P2X7 receptor agonist BzATP enhances Fyn kinase activity. Blocking Fyn activity or downregulating Fyn expression inhibits BzATP-induced oligodendrocyte progenitor cell migration. Co-immunoprecipitation of P2X7 and Fyn, Fyn kinase activity assay, Fyn inhibitor and siRNA knockdown, OPC migration assay Purinergic signalling Low 26099359
2023 CD28-containing CAR-T cells signal through FYN kinase rather than LCK for their primary activation. FYN-dependent CAR signaling (requiring both FYN and CD28 intracellular domain) promotes T cell proliferation and memory formation, whereas LCK-dependent signaling leads to exhaustion. LCK-deficient CAR-T cells with intact FYN show superior in vivo anti-tumor efficacy. LCK-deficient CAR-T cells, in vivo CAR-T efficacy models, phenotypic analysis of exhaustion/memory markers, CD28 domain mutant CARs Cell reports. Medicine Medium 36696897
2010 Fyn kinase localizes to the egg cortex, polar body, fertilizing cone, and meiotic/mitotic spindles of rat eggs. In mammalian oocytes, Fyn concentrates asymmetrically at the site of cleavage furrow ingression co-localizing with F-actin during meiosis and mitosis; dominant-negative Fyn prolongs furrow ingression duration and leads to larger polar bodies and longer spindles. Live-cell confocal imaging, microinjection of Fyn cRNA (wild-type and dominant-negative), SFK inhibitor SU6656, polar body extrusion timing and spindle length measurement Reproduction (Cambridge, England) Medium 20841362
2007 Fyn phosphorylates APP at Tyr757 of the YENPTY motif and increases APP cell-surface expression. In the presence of Dab1, Fyn significantly increases sAPPα production and C-terminal fragment levels, and potentiates Dab1-dependent APP phosphorylation and surface trafficking. Fyn-KO mice show reduced sAPPα in vivo. Co-immunoprecipitation, co-immunostaining, FLIM (fluorescence lifetime imaging), Fyn overexpression with/without Dab1, Fyn-KO mouse brain analysis The Journal of biological chemistry Medium 18089558
2019 Fyn kinase activity is regulated by submembrane localization: a FRET biosensor shows that Fyn outside its membrane microdomains is hyperactive, while microdomains provide a suppressive microenvironment. A relatively high Fyn activity is also observed at perinuclear regions. FRET biosensor for Fyn kinase activity in live cells, membrane microdomain-targeted biosensor variants (Fyn-tag vs. Lyn-tag), pharmacological perturbations of membrane domains ACS sensors Medium 30588803

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nature genetics 516 24413734
2006 Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions. Cell 431 16413486
2002 Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nature immunology 358 12089510
1995 Specific and redundant roles of Src and Fyn in organizing the cytoskeleton. Nature 302 7617039
2015 Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Annals of neurology 254 25707991
2003 Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Current biology : CB 240 12526739
2019 Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. The Journal of experimental medicine 209 31036561
2003 Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin. The Journal of biological chemistry 190 12668668
1999 Fyn and JAK2 mediate Ras activation by reactive oxygen species. The Journal of biological chemistry 171 10409649
2010 Fyn: a novel molecular target in cancer. Cancer 168 20151426
2005 Absence of Fyn and Src causes a reeler-like phenotype. The Journal of neuroscience : the official journal of the Society for Neuroscience 166 16162939
2011 Regulation of NMDA receptors by the tyrosine kinase Fyn. The FEBS journal 161 21985328
2014 Fyn kinase inhibition as a novel therapy for Alzheimer's disease. Alzheimer's research & therapy 153 24495408
2017 Targeting Fyn Kinase in Alzheimer's Disease. Biological psychiatry 133 28709498
1998 Fyn, a Src family tyrosine kinase. The international journal of biochemistry & cell biology 116 9839441
1993 The protein tyrosine kinase, fyn, in Alzheimer's disease pathology. Neuroreport 116 8388744
2004 SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin. Journal of the American Society of Nephrology : JASN 115 15579503
2013 The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. Journal of virology 106 23616652
2009 Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase. Journal of cell science 102 19258392
1995 fyn tyrosine kinase is involved in keratinocyte differentiation control. Genes & development 101 7557381
2015 Fyn is an important molecule in cancer pathogenesis and drug resistance. Pharmacological research 100 26305432
2009 Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA. Development (Cambridge, England) 100 19141671
2017 Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation. Nature communications 98 28811476
2012 Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease. Prion 98 22987042
2006 Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge. Molecular biology of the cell 91 16597701
2003 Alphavbeta6-Fyn signaling promotes oral cancer progression. The Journal of biological chemistry 89 12917446
2010 Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration. Molecular carcinogenesis 83 21480388
2016 Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. The Journal of clinical investigation 74 27525436
2021 GSK-3β, FYN, and DYRK1A: Master Regulators in Neurodegenerative Pathways. International journal of molecular sciences 71 34445804
2000 A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation. Molecular cell 71 11106751
2020 Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions. International journal of molecular sciences 69 32580508
2011 Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer. Carcinogenesis 69 21642356
2019 Aβ oligomers promote oligodendrocyte differentiation and maturation via integrin β1 and Fyn kinase signaling. Cell death & disease 68 31171765
2013 microRNA-125a-3p reduces cell proliferation and migration by targeting Fyn. Journal of cell science 68 23606749
2011 Fyn kinase in brain diseases and cancer: the search for inhibitors. Current medicinal chemistry 66 21651487
2018 Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway. Annals of the rheumatic diseases 65 29555825
2020 Fyn Kinase Controls Tau Aggregation In Vivo. Cell reports 61 32814048
1998 Expression and immunolocalization of p59c-fyn tyrosine kinase in rat eggs. Developmental biology 61 9473330
2015 Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts. PLoS computational biology 59 25884760
2006 A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling. Molecular and cellular neurosciences 59 16860569
2023 FYN: emerging biological roles and potential therapeutic targets in cancer. Journal of translational medicine 56 36740671
2002 Fyn tyrosine kinase in Sertoli cells is involved in mouse spermatogenesis. Biology of reproduction 51 11751285
1998 CD73 expression and fyn-dependent signaling on murine lymphocytes. European journal of immunology 51 9808167
2016 Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3. Kidney international 50 27616741
2011 Fyn, a potential target for Alzheimer's disease. Journal of Alzheimer's disease : JAD 50 21799250
2020 Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy. Acta neuropathologica communications 49 32611392
2000 T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase. Proceedings of the National Academy of Sciences of the United States of America 47 11005864
2016 Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology. Cancer metastasis reviews 46 27067725
2006 Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events. Angiogenesis 46 16400523
2007 Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. The Journal of biological chemistry 44 18089558
2015 Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination. Glia 42 26449489
2020 Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses. Neuro-oncology 41 31950181
2019 NT5DC2 promotes tumorigenicity of glioma stem-like cells by upregulating fyn. Cancer letters 40 30978441
2005 Protein tyrosine phosphatase alpha regulates Fyn activity and Cbp/PAG phosphorylation in thymocyte lipid rafts. Journal of immunology (Baltimore, Md. : 1950) 39 16339530
2003 Deletion of the fyn-kinase gene alters behavioral sensitivity to ethanol. Alcoholism, clinical and experimental research 39 12878908
2023 CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance. Cell reports. Medicine 37 36696897
2018 Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn. Journal of Alzheimer's disease : JAD 37 29782321
2018 Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis. American journal of hematology 37 30252956
2021 Fyn Kinase Activity and Its Role in Neurodegenerative Disease Pathology: a Potential Universal Target? Molecular neurobiology 36 34432266
2015 Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity. Cell death and differentiation 36 26001218
2015 Striatal-enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway. Journal of neurochemistry 35 25951993
2012 Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent. PloS one 34 22715382
2020 Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma. Molecular cancer therapeutics 33 32430486
2015 P2X7 receptors and Fyn kinase mediate ATP-induced oligodendrocyte progenitor cell migration. Purinergic signalling 33 26099359
2004 Lipid rafts: resolution of the "fyn problem"? Molecular immunology 33 15220001
2016 MOBP levels are regulated by Fyn kinase and affect the morphological differentiation of oligodendrocytes. Journal of cell science 32 26801084
2016 FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia. Oncotarget 32 26848862
2013 A 'danse macabre': tau and Fyn in STEP with amyloid beta to facilitate induction of synaptic depression and excitotoxicity. The European journal of neuroscience 31 23773061
1992 Cell type and developmental regulation of the fyn proto-oncogene in neural retina. Oncogene 31 1741169
2021 Src and Fyn regulation of NMDA receptors in health and disease. Neuropharmacology 30 34051267
2020 FYN promotes gastric cancer metastasis by activating STAT3-mediated epithelial-mesenchymal transition. Translational oncology 30 32763503
2010 Fyn kinase is involved in cleavage furrow ingression during meiosis and mitosis. Reproduction (Cambridge, England) 30 20841362
2006 Srcasm corrects Fyn-induced epidermal hyperplasia by kinase down-regulation. The Journal of biological chemistry 30 17046829
2016 KLF5 promotes cell migration by up-regulating FYN in bladder cancer cells. FEBS letters 29 26786295
2015 Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination. Molecular biology of the cell 29 26224309
2009 Roles of Fyn in pancreatic cancer metastasis. Journal of gastroenterology and hepatology 29 19968749
2016 Ligand-induced growth and compaction of CD36 nanoclusters enriched in Fyn induces Fyn signaling. Journal of cell science 28 27694211
2015 SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer. Oncotarget 28 26624980
1997 Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development. European journal of immunology 28 9045930
2021 FYN-TRAF3IP2 induces NF-κB signaling-driven peripheral T cell lymphoma. Nature cancer 27 33928261
2015 Fyn in Neurodevelopment and Ischemic Brain Injury. Developmental neuroscience 27 25720756
2012 Role of FYN kinase in spermatogenesis: defects characteristic of Fyn-null sperm in mice. Biology of reproduction 26 21918125
2012 Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. Journal of immunology (Baltimore, Md. : 1950) 26 22450804
2012 Expression and activity of Fyn mediate proliferation and blastic features of chronic myelogenous leukemia. PloS one 26 23284724
2010 Role of Fyn kinase in oocyte developmental potential. Reproduction, fertility, and development 26 20591331
2008 The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly. PloS one 26 18301737
2020 Fyn Kinase: A Potential Therapeutic Target in Acute Kidney Injury. Biomolecules & therapeutics 25 32336052
2015 Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members. Gene 25 26119091
2015 The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells. Frontiers in immunology 25 26441977
2020 FYN is required for ARHGEF16 to promote proliferation and migration in colon cancer cells. Cell death & disease 24 32811808
2017 Fyn knockdown inhibits migration and invasion in cholangiocarcinoma through the activated AMPK/mTOR signaling pathway. Oncology letters 24 29434909
2015 A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies. Oncotarget 24 26136341
2013 Fyn-dependent gene networks in acute ethanol sensitivity. PloS one 24 24312422
2009 FYN kinase gene: another glutamatergic gene associated with bipolar disorder? Neuropsychobiology 24 19468241
2014 The Role of TLR4 and Fyn Interaction on Lipopolysaccharide-Stimulated PAI-1 Expression in Astrocytes. Molecular neurobiology 23 25106729
2013 Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction. Molecular and cellular biology 23 23438599
2011 The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane. The Journal of biological chemistry 23 22057277
2008 Lysophosphatidic acid induces ovarian cancer cell dispersal by activating Fyn kinase associated with p120-catenin. International journal of cancer 23 18506685
1999 Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signaling. International immunology 23 10464165
2019 Sensitive FRET Biosensor Reveals Fyn Kinase Regulation by Submembrane Localization. ACS sensors 22 30588803

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