Affinage

PABPC1

Polyadenylate-binding protein 1 · UniProt P11940

Length
636 aa
Mass
70.7 kDa
Annotated
2026-06-10
100 papers in source corpus 34 papers cited in narrative 34 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PABPC1 is the principal cytoplasmic poly(A)-binding protein, coating mRNA poly(A) tails through its tandem RRM domains and acting as a central hub that couples poly(A) status to translation, mRNA stability, and surveillance (PMID:35307347, PMID:20144953). It uses its modular architecture for combinatorial control: the RRM domains engage the poly(A) tail and competing regulators—Paip2A binds the RRM2–RRM3 interface to displace PABPC1 and repress poly(A)-dependent translation (PMID:35307347), while the APRO/boxC domains of BTG1/BTG2 dock on RRM1 to stimulate CAF1/CCR4-NOT deadenylase activity (PMID:26912148, PMID:34060423). Its C-terminal MLLE domain recognizes PAM2 motifs in a family of effectors, including GW182/TNRC6, LARP1, LARP4B, Tob2, and Pan3, and these PAM2 contacts are tuned by phosphorylation of the flanking disordered regions (PMID:21063388, PMID:23340509, PMID:33292040, PMID:32517187). Through GW182 and association with the CCR4-NOT complex, PABPC1 enables miRNA-directed deadenylation and silencing, and it cooperates with AGO2 to enhance RISC recruitment (PMID:19797087, PMID:21063388, PMID:26188282), whereas its interactions with eIF4G, eIF3, and the release factor eRF3 link initiation to efficient termination and form the basis of its role in NMD: PABPC1 position relative to the stop codon is a key determinant of premature-termination-codon definition in higher eukaryotes (PMID:19797087, PMID:21989405, PMID:17318186). A layer of post-translational modification dynamically gates these activities—nonproteolytic ubiquitination by the E3 ligase MKRN3 regulates global protein synthesis and proliferation, USP10-mediated deubiquitination of RRM2 selectively boosts translation of target mRNAs, and stress-induced SUMOylation drives stress-granule assembly via a TIA1 complex that stabilizes U-rich mRNAs (PMID:34143182, PMID:37757903, PMID:40774970). PABPC1 also shuttles between nucleus and cytoplasm, contributing to mRNA export and to nuclear retention of A-rich circRNAs, and serves as an antiviral target cleaved by enteroviral 3C proteases to shut down host translation (PMID:15769879, PMID:38838666, PMID:32512928, PMID:40294010). De novo variants in its PABP domain that weaken the PABPC1–PAIP2 interaction cause a developmental-delay disorder and impair neural progenitor proliferation (PMID:35511136).

Mechanistic history

Synthesis pass · year-by-year structured walk · 33 steps
  1. 1997 High

    Established that the poly(A)-binding protein is not merely a passive tail coat but an active participant in 3'-end processing, linking it physically to the cleavage/polyadenylation machinery and to control of poly(A) tail length.

    Evidence Two-hybrid, Co-IP, co-purification with CF I component Rna15, and in vitro polyadenylation with pab1 mutant extracts plus recombinant add-back in yeast

    PMID:9199303

    Open questions at the time
    • Did not resolve which RRM domains mediate the CF I interaction
    • Yeast-based; relevance to metazoan PABPC1 not addressed in this study
  2. 2001 Medium

    Showed that the Pab1–eIF4G closed-loop contact required for translation is itself chaperone-dependent, placing Hsp70/Hsp40 upstream of PABP function on translating ribosomes.

    Evidence Polysome Co-IP, domain mapping, and Ssa depletion followed by Pab1–eIF4G interaction assay in yeast

    PMID:11279042

    Open questions at the time
    • Mechanism by which Ssa promotes the interaction (folding vs. assembly) not defined
    • Not tested in metazoan systems
  3. 2005 High

    Demonstrated that PABP is a nucleocytoplasmic shuttling protein with defined import and export receptors, connecting it to mRNA export rather than confining it to cytoplasmic translation.

    Evidence LMB export inhibition, fractionation, direct Xpo1/Crm1 binding, Kap108/Sxm1 import receptor mapping to RRM4, and rrp6 genetic suppression in yeast

    PMID:15769879

    Open questions at the time
    • Nuclear function distinct from export not delineated
    • Human PABPC1 shuttling receptors not mapped here
  4. 2007 High

    Identified PABPC1 position relative to the stop codon as a determinant of premature-termination-codon definition, giving the protein a direct role in mRNA surveillance/NMD.

    Evidence Tethering downstream of a PTC, 3'-UTR elongation, and PABPC1 depletion in Drosophila cells

    PMID:17318186

    Open questions at the time
    • Molecular link between PABPC1 position and the NMD machinery not fully defined
    • Insect-cell findings
  5. 2008 High

    Revealed that the poly(A)/Pab1 NMD model is not universal: in yeast neither poly(A) nor Pab1 is required for substrate recognition, sharpening the surveillance role as a higher-eukaryote feature.

    Evidence Poly(A)-less PTC reporters and pab1Δ NMD reporter assays in yeast

    PMID:18206975

    Open questions at the time
    • Does not explain the basis of the metazoan-specific positional dependence
    • Negative result; what substitutes for Pab1 in yeast NMD unaddressed
  6. 2009 High

    Mechanistically connected PABPC1 to miRNA silencing by showing GW182 competes with eIF4G for PABPC1 and that this contact is required for target deadenylation and repression.

    Evidence Reciprocal Co-IP, tethering, overexpression rescue, and CCR4-NOT association in Drosophila and human cells

    PMID:19797087

    Open questions at the time
    • Did not map the precise GW182 surfaces (resolved later)
    • Whether eIF4G displacement is sufficient for repression untested
  7. 2010 High

    Defined a bipartite GW182–PABPC1 interaction (PAM2/MLLE plus N-terminal contacts) and proved a single PAM2 residue controls silencing, establishing the MLLE–PAM2 module as functionally essential.

    Evidence Domain mapping, point mutagenesis, Co-IP, and silencing assays in Drosophila and human cells

    PMID:21063388

    Open questions at the time
    • Structural basis of MLLE–PAM2 recognition not resolved here
    • Relative contribution of each contact to deadenylation vs. repression unquantified
  8. 2010 High

    Proposed that PABP self-association/circularization removes it from the poly(A) tail to license CCR4 deadenylation, coupling PABP conformational state to mRNA turnover.

    Evidence Domain-deletion mutants, in vivo deadenylation, and analytical ultracentrifugation in yeast

    PMID:17620415

    Open questions at the time
    • Trigger for self-association in vivo unknown
    • Yeast-specific; human PABPC1 oligomerization not tested
  9. 2010 Medium

    Showed by ectopic mitochondrial targeting that poly(A) coating by PABPC1 directly governs translation efficiency rather than transcript stability, isolating its translational function on a poly(A) tail.

    Evidence Mitochondrial targeting fusion (mtPABP1), steady-state mt-mRNA measurement, and mitochondrial translation assay in mammalian cells

    PMID:20144953

    Open questions at the time
    • Artificial mitochondrial context
    • Endogenous mitochondrial poly(A)-binding factor identity not established
  10. 2011 High

    Linked PABPC1's translation-factor contacts (eIF4G, eIF3, eRF3) to NMD resistance at AUG-proximal PTCs, providing a molecular basis for how termination context determines surveillance.

    Evidence Reciprocal Co-IP, ribosome stalling assays, and NMD reporters in human cells

    PMID:21989405

    Open questions at the time
    • Causal order of factor recruitment during termination not resolved
    • Quantitative contribution of each contact unmeasured
  11. 2012 Medium

    Connected PABPC1 to neurodegeneration by showing expanded ATXN2 sequesters it into insolubility, implicating loss of soluble PABPC1 in disease pathology.

    Evidence ATXN2 CAG42 knock-in mouse fractionation/immunoblot and human cell-culture validation

    PMID:22956915

    Open questions at the time
    • Functional consequence of PABPC1 sequestration on translation not measured
    • Causality vs. correlation in disease progression unresolved
  12. 2013 Medium

    Established phosphorylation of PAM2-flanking disordered regions as a switch tuning effector binding to PABPC1, adding a regulatory layer to MLLE-mediated interactions.

    Evidence Phosphomimetic/phospho-blocking mutants of Tob2, Pan3, Tnrc6c with Co-IP and mRNA stability/silencing reporters

    PMID:23340509

    Open questions at the time
    • Responsible kinases not identified
    • In vivo signaling contexts that trigger these phosphorylations unknown
  13. 2014 Medium

    Distinguished the yeast Pab1–eRF3 termination-regulatory function from its eRF3-independent mRNA-stability role, and showed the metazoan PAM2-based eRF3 contact differs mechanistically from yeast.

    Evidence Domain deletion, genetic epistasis, readthrough and mRNA stability assays in yeast

    PMID:25411355

    Open questions at the time
    • Yeast eRF3 binding mode not structurally defined
    • Direct extrapolation to human eRF3 limited
  14. 2016 High

    Reconstituted minimal deadenylation stimulation, showing the BTG2 APRO domain plus PABPC1 RRM1 are sufficient to activate CAF1, and linked this contact to proliferation control.

    Evidence In vitro deadenylase assay with purified proteins, domain mapping, proliferation assays with interaction-deficient mutants

    PMID:26912148

    Open questions at the time
    • How RRM1 engagement positions CAF1 on the tail not structurally resolved
    • Role of full CCR4-NOT in the in vivo reaction not addressed
  15. 2017 Medium

    Implicated PABPC1 in immune cell mRNA processing by promoting hnRNPLL binding and IgH membrane-to-secreted isoform switching via alternative polyadenylation.

    Evidence Co-IP, RIP, and functional switching assays in plasma cells

    PMID:28611064

    Open questions at the time
    • Mechanism by which PABPC1 favors a specific poly(A) site unclear
    • Direct vs. indirect effect on hnRNPLL recruitment not separated
  16. 2017 Medium

    Demonstrated that poly(A) tail-length control of PABPC1's own synthesis titrates cellular translation capacity, identifying it as a regulator of cardiac hypertrophy.

    Evidence Poly(A) tail measurements, PABPC1 knockdown/overexpression, and in vivo/in vitro hypertrophy models in cardiomyocytes

    PMID:28653618

    Open questions at the time
    • Upstream cues setting PABPC1 mRNA tail length not defined
    • Whether this is tissue-specific unaddressed
  17. 2018 Medium

    Showed PABPC1 partners with PIWIL1 to augment translation of spermiogenic mRNAs, extending its translational-activator role to germ-cell post-meiotic gene expression.

    Evidence Domain-level Co-IP, luciferase reporter, and polysome profiling in a heterologous cell system

    PMID:29701755

    Open questions at the time
    • Endogenous germ-cell validation limited
    • RNA-dependence of the interaction not mechanistically dissected
  18. 2020 High

    Provided the structural basis for MLLE–PAM2 recognition by solving the LARP4B PAM2w–MLLE crystal structure, revealing a new variant binding mode.

    Evidence X-ray crystallography with in vitro and in vivo mutational validation

    PMID:32517187

    Open questions at the time
    • Functional output of LARP4B–PABPC1 binding not quantified here
    • Generality across other PAM2 variants untested in this structure
  19. 2020 Medium

    Established that LARP1's La-module stabilizes mRNA and protects poly(A) length specifically through its PAM2–PABPC1 contact, separating the in vivo stabilization role from intrinsic RNA binding.

    Evidence PAM2 point mutagenesis, mRNA stability assays, in vitro RNA binding, and Co-IP in HEK293 cells

    PMID:33292040

    Open questions at the time
    • Mechanism of poly(A) protection (occlusion vs. deadenylase exclusion) not resolved
    • Single cell system
  20. 2020 Medium

    Showed PABPC1 is required for LARP1 to engage its mRNA targets, including TOP mRNAs, placing PABPC1 upstream of LARP1-mediated translational repression.

    Evidence mRNA interactome capture, PABPC1-knockdown effect on LARP1 binding, and polysome profiling

    PMID:33332560

    Open questions at the time
    • Whether PABPC1 directly handoffs mRNA to LARP1 or acts indirectly unresolved
    • Effect on translation of specific targets not quantified per-transcript
  21. 2020 Medium

    Identified PABPC1 as an antiviral factor cleaved by SVV 3C protease, showing host poly(A)-binding capacity is targeted to suppress host translation during infection.

    Evidence 3Cpro active-site mutagenesis, cleavage-site mapping at residue 437, and protein synthesis rate measurement

    PMID:32512928

    Open questions at the time
    • Functional consequence of each cleavage fragment not defined
    • In vivo relevance to viral pathogenesis unaddressed
  22. 2020 Medium

    Showed PABPC1 enhances RISC function by interacting with AGO2 in the cytoplasm to increase mRNA recruitment, deepening its role in miRNA-mediated regulation in cancer cells.

    Evidence Anti-AGO2 Co-IP/MS, cytoplasmic fractionation, and miRNA reporter assays in HCC cells

    PMID:26188282

    Open questions at the time
    • Direct vs. RNA-bridged AGO2 contact not distinguished
    • Single cancer cell context
  23. 2021 High

    Identified MKRN3 as the E3 ligase that nonproteolytically ubiquitinates PABPC1 to regulate global protein synthesis and proliferation, with patient mutations impairing this activity.

    Evidence MS substrate screen, in vitro ubiquitination, patient mutation analysis, and MKRN3-knockout mouse models

    PMID:34143182

    Open questions at the time
    • Ubiquitin linkage type and modified residues not fully mapped
    • How nonproteolytic ubiquitin alters PABPC1 activity mechanistically unclear
  24. 2021 High

    Defined a conserved boxC motif in BTG1/BTG2 APRO domains as necessary and sufficient for PABPC1 RRM1 binding and deadenylation stimulation, refining the deadenylation-activation interface.

    Evidence NMR chemical shift perturbation, mutagenesis, pulldowns, and in vitro/in cellulo deadenylation assays

    PMID:34060423

    Open questions at the time
    • Structural model of the ternary RRM1–boxC–deadenylase assembly not solved
    • Selectivity between BTG1 and BTG2 functions unaddressed
  25. 2022 High

    Resolved the molecular logic of Paip2A-mediated translational repression: sequential RRM2 then RRM3 engagement displaces PABPC1 from poly(A), defining a competitive eviction mechanism.

    Evidence ITC, NMR, and competition binding with isolated RRM domains

    PMID:35307347

    Open questions at the time
    • Cellular triggers controlling Paip2A availability not addressed
    • Kinetics of eviction on full-length mRNP unmeasured
  26. 2022 Medium

    Established PABPC1 (PABP domain) as a developmental-delay disease gene, with variants weakening the PAIP2 interaction and failing to support neural progenitor proliferation.

    Evidence Exome sequencing, Co-IP, in silico modeling, and in utero electroporation rescue in mouse embryo brain

    PMID:35511136

    Open questions at the time
    • Whether weakened PAIP2 binding is the causal mechanism for all variants unconfirmed
    • Downstream translational targets affected in neural progenitors unidentified
  27. 2022 Medium

    Showed acetylation of Pab1 at K131 by reducing poly(A) binding suppresses stress-granule formation, with Rpd3 as the deacetylase, adding acetylation as a stress-responsive switch.

    Evidence Acetylation-mimetic mutants, stress-granule imaging, EMSA, and rpd3 genetic epistasis in yeast

    PMID:36572187

    Open questions at the time
    • Acetyltransferase responsible not identified
    • Human PABPC1 K131 acetylation not tested
  28. 2023 Medium

    Demonstrated USP10 deubiquitinates K27/K29 chains on PABPC1 RRM2 to enhance coupling of specific mRNAs to eIF4G1, providing a tumor-promoting translational control mechanism.

    Evidence Co-IP, deubiquitination and linkage-specific assays, RRM2 mutants, and xenograft models in PDAC

    PMID:37757903

    Open questions at the time
    • Counterbalancing E3 ligase for these chains not defined here
    • Selectivity for CLK2 mRNA mechanistically unexplained
  29. 2024 Medium

    Revealed a nuclear function in which PABPC1, with TPR, retains A-rich circRNAs in the nucleus, and its downregulation during differentiation permits circRNA export required for neurite outgrowth.

    Evidence Nuclear/cytoplasmic fractionation, PABPC1 manipulation, circRNA A-rich motif mutagenesis, neurite assays, and TPR Co-IP

    PMID:38838666

    Open questions at the time
    • How PABPC1 distinguishes circRNA from linear poly(A) substrates unclear
    • Generality beyond stem-cell/neuronal context untested
  30. 2024 Medium

    Implicated PABPC1 in degradation of pathogenic C9orf72 GGGGCC repeat RNA via interactions with hnRNPA3 and the RNA exosome, linking it to repeat-expansion disease surveillance.

    Evidence APEX2 proximity biotinylation, proximity ligation, and PABPC1-knockdown repeat-RNA accumulation assays

    PMID:38444607

    Open questions at the time
    • Direct exosome recruitment vs. indirect effect not separated
    • Proximity-based evidence lacks reconstitution
  31. 2025 High

    Identified PABPC1 condensate formation as a driver of leukaemogenic mRNA translation in CML blast crisis, nominating it as a therapeutic target that overcomes TKI resistance.

    Evidence Genome-scale CRISPR screen, condensate imaging, polysome profiling, translation-efficiency analysis, and pharmacological inhibition in CML models

    PMID:40102686

    Open questions at the time
    • Determinants of condensate selectivity for structured 5' UTR mRNAs not defined
    • How condensation alters initiation kinetics mechanistically unresolved
  32. 2025 High

    Showed stress-induced SUMOylation of PABPC1 drives stress-granule assembly via a TIA1 complex that selectively stabilizes U-rich mRNAs and supports mitophagy gene expression.

    Evidence SUMOylation assays, stress-granule imaging, transcriptome-wide stability analysis, TIA1 Co-IP, and mitophagy readouts

    PMID:40774970

    Open questions at the time
    • SUMO sites and responsible E3 ligase not fully mapped
    • How SUMO-PABPC1 selects U-rich elements mechanistically unclear
  33. 2025 High

    Used acute Pab1 depletion to show its primary in vivo role is blocking decapping/decay, with closed-loop eIF4G contact dispensable for most yeast translation, reframing the canonical scaffolding model.

    Evidence Auxin-inducible degron depletion, RNA-Seq, Ribo-Seq, dcp2Δ epistasis, and polysome profiling in yeast

    PMID:40071937

    Open questions at the time
    • Whether the same hierarchy holds in metazoan PABPC1 untested
    • Transcript subsets that do require closed-loop initiation not fully enumerated

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how the array of PABPC1 post-translational modifications, conformational states, and partner interactions are integrated to determine, on a given mRNA, whether PABPC1 promotes translation, licenses deadenylation, or drives condensate/stress-granule sequestration.
  • No unified model linking modification state to functional output
  • Quantitative rules governing partner competition on a single mRNP unknown
  • Crosstalk between nuclear and cytoplasmic functions undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 5 GO:0045182 translation regulator activity 5 GO:0060090 molecular adaptor activity 5 GO:0098772 molecular function regulator activity 3
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 2
Pathway
R-HSA-392499 Metabolism of proteins 5 R-HSA-8953854 Metabolism of RNA 5 R-HSA-1643685 Disease 4 R-HSA-8953897 Cellular responses to stimuli 2
Partners
AGO2BTG2EIF4G1ERF3LARP1PAIP2TIA1TNRC6A
Complex memberships
CCR4-NOT (associated)stress granule

Evidence

Reading pass · 34 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 PABPC1 position relative to the stop codon is a critical determinant for PTC definition in NMD: tethering PABPC1 downstream of a premature termination codon (PTC) abolishes NMD in Drosophila, while elongating the 3' UTR of natural stop codons triggers NMD. Depletion of PABPC1 also suppresses NMD independently of translation efficiency effects, indicating PABPC1 has a direct role in mRNA surveillance beyond positional information. PABPC1 tethering assays, 3' UTR length manipulation, PABPC1 depletion in Drosophila melanogaster cells The EMBO journal High 17318186
2009 The GW182 silencing domain competes with eIF4G for binding to PABPC1; the GW182–PABPC1 interaction is required for miRNA target deadenylation and translational repression. PABPC1 overexpression suppresses miRNA-mediated silencing. PABPC1 also associates with components of the CCR4-NOT deadenylase complex. Co-immunoprecipitation, tethering assays, overexpression rescue experiments, interaction domain mapping in Drosophila and human cells Molecular and cellular biology High 19797087
1997 Yeast Pab1 interacts with Rna15, a component of cleavage and polyadenylation factor CF I, and copurifies with CF I. Pab1 participates in controlling poly(A) tail length during polyadenylation in vitro: immunoneutralization or thermosensitive pab1 mutant extracts produce longer poly(A) tails, which are restored by adding recombinant Pab1. Two-hybrid assay, co-immunoprecipitation, anion-exchange chromatography co-purification, in vitro polyadenylation assay with mutant extracts and recombinant protein add-back Molecular and cellular biology High 9199303
2010 Two distinct regions of GW182 proteins interact with PABPC1: one contains a PAM2 motif (binding the PABPC1 MLLE/C-terminal domain) and the second contains M2 and C-terminal sequences mediating indirect binding to the PABPC1 N-terminal domain. A single amino acid substitution in the TNRC6A-C PAM2 motif abolishes the interaction with PABPC1 and impairs GW182 silencing activity. Co-immunoprecipitation, domain mapping, point mutagenesis, silencing activity assays in Drosophila and human cells The EMBO journal High 21063388
2010 Yeast Pab1 self-association (oligomerization and circularization) via its proline-rich region and RRM1 domains is required for CCR4 deadenylation in vivo. Self-associated PAB1 multimers and circular PAB1 species are unable to bind poly(A), and removal of RRM3 (which promoted oligomerization) accelerates CCR4 deadenylation, supporting a model where PAB1 self-association removes it from the poly(A) tail to permit deadenylation. Deletion mutagenesis of PAB1 domains, in vivo deadenylation assays, protein-protein interaction assays, analytical ultracentrifugation Molecular and cellular biology High 17620415
2005 Yeast Pab1 shuttles between nucleus and cytoplasm, functioning as export cargo of Xpo1/Crm1 via RanGTP-dependent interaction, and can also exit via the MEX67 mRNA export pathway. Import is mediated by Kap108/Sxm1 through a nuclear localization signal in Pab1's fourth RRM domain. Inhibition of Pab1 nuclear import causes a kinetic delay in mRNA export, and pab1Δ lethality is suppressed by deletion of the nuclear exosome subunit RRP6. Nuclear export inhibition (LMB treatment), subcellular fractionation, direct binding assay with Xpo1/Crm1, genetic epistasis (rrp6 suppressor), import receptor identification RNA High 15769879
2011 PABPC1 interactions with the cap-binding complex subunit eIF4G and the 40S recruitment factor eIF3, as well as the ribosome release factor eRF3, underlie critical 3'–5' linkage of translation initiation with efficient termination at AUG-proximal PTCs, providing NMD resistance. Translation termination at AUG-proximal PTCs lacks ribosome stalling seen at NMD-sensitive PTCs. Co-immunoprecipitation of PABPC1 with eIF4G, eIF3, and eRF3; ribosome stalling assays; NMD reporter assays in human cells Nucleic acids research High 21989405
2016 The APRO domain of BTG2 interacts directly with the first RRM domain of PABPC1. The PABPC1 RRM1 and BTG2 APRO domains together are sufficient to stimulate CAF1 deadenylase activity in vitro without other CCR4-NOT subunits. BTG2's interaction with PABPC1 RRM1 is required for BTG2 to control cell proliferation. In vitro deadenylase activity assay with purified proteins, domain mapping, cell proliferation assay with interaction-deficient mutants Nature communications High 26912148
2021 MKRN3 E3 ligase ubiquitinates PABPC1 (identified by mass spectrometry proteomics screen as major substrate). MKRN3 missense mutations found in patients substantially compromise MKRN3-mediated PABPC1 ubiquitination. MKRN3 modulates cell proliferation through nonproteolytic PABPC1 ubiquitination, which in turn regulates PABPC1-mediated global protein synthesis. Mass spectrometry substrate screen, in vitro ubiquitination assay, patient mutation analysis, cell proliferation assays, MKRN3 knockout mouse models The Journal of experimental medicine High 34143182
2022 Paip2A competitively binds to the RRM2–RRM3 regions of PABPC1 at the same interface as poly(A), with higher affinity for RRM2 and RRM3 individually than poly(A). Paip2A initially binds RRM2 of poly(A)-bound PABPC1, then displaces RRM3 from poly(A), causing dissociation of the whole PABPC1 molecule and thereby repressing poly(A)-dependent translation. Isothermal titration calorimetry (ITC), NMR chemical shift perturbation analysis, competition binding experiments with isolated RRM domains The Journal of biological chemistry High 35307347
2010 Targeting cytosolic PABPC1 to mitochondria (as mtPABP1) coats the mitochondrial poly(A) tail but does not cause transcript decay; instead, it causes marked inhibition of mitochondrial translation, demonstrating that poly(A) tail-binding by PABPC1 is functionally important for translation and that endogenous poly(A)-binding factors interact with the mt-mRNA poly(A) tail to optimize mitochondrial protein synthesis. Mitochondrial targeting sequence fusion constructs, steady-state mt-mRNA level measurement, mitochondrial translation assay in mammalian cells Nucleic acids research Medium 20144953
2013 Phosphorylation at serine/threonine residues in intrinsically disordered regions flanking PAM2 motifs of PAM2-containing proteins (Tob2, Pan3, Tnrc6c) regulates their interactions with PABPC1; phosphomimetic mutations in these proteins reduce binding to PABPC1 and impair their functions in mRNA turnover and gene silencing. Phosphorylation state manipulation (kinase activation, phosphatase inhibition), phospho-blocking and phosphomimetic mutants, Co-immunoprecipitation, mRNA stability and gene silencing reporter assays RNA Medium 23340509
2017 PABPC1 directly interacts with hnRNPLL in T cells and plasma cells. Although PABPC1 is not required for alternative splicing of CD45, it promotes hnRNPLL binding to immunoglobulin mRNA and regulates switching from membrane to secreted IgH isoform through mRNA alternative polyadenylation. Co-immunoprecipitation, RNA immunoprecipitation, functional switching assays in plasma cells The Journal of biological chemistry Medium 28611064
2017 Regulated changes in poly(A) tail length dynamically control PABPC1 protein synthesis in cardiomyocytes, titrating cellular translation capacity in response to developmental and hypertrophic cues. PABPC1 is identified as a direct regulator of cardiac hypertrophy. Poly(A) tail length measurements, PABPC1 knockdown and overexpression in cardiomyocytes, cardiac hypertrophy models in vivo and in vitro eLife Medium 28653618
2020 PABPC1 interacts with AGO2 in the cytoplasm of HCC cells; this interaction increases recruitment of mRNA to RISC and enhances miRNA-mediated inhibition efficiency. Anti-AGO2 co-immunoprecipitation and mass spectrometry, cytoplasmic fractionation, functional miRNA reporter assays Cancer letters Medium 26188282
2021 LARP1 requires PABPC1 for association with its specific mRNA targets: the mRNA interactome of LARP1 and PABPC1 show high overlap, and PABPC1 depletion reduces LARP1 binding to its mRNA targets including TOP-containing mRNAs. mRNAs bound by both LARP1 and PABPC1 are in a translationally repressed state. RNA-binding protein capture (mRNA interactome), PABPC1 knockdown effect on LARP1 mRNA binding, polysome profiling Nucleic acids research Medium 33332560
2020 The isolated La-module of LARP1 mediates poly(A) length protection and mRNA stabilization in a manner dependent on its PAM2 motif binding to PABPC1. A point mutation in the PAM2 motif impairs mRNA stabilization and PABP binding in vivo without affecting oligo(A) RNA binding by the purified recombinant La-module in vitro. PAM2 point mutagenesis, mRNA stability assays in HEK293 cells, in vitro RNA binding assay with recombinant protein, Co-immunoprecipitation RNA biology Medium 33292040
2020 The viral protease SVV 3Cpro cleaves PABPC1 at residue 437, generating N-terminal (50 kDa) and C-terminal (25 kDa) fragments. PABPC1 inhibits SVV replication, and 3Cpro cleavage of PABPC1 (dependent on active site residues H48 and C160 of 3Cpro) decreases host protein synthesis rates. Viral infection and protease expression, point mutagenesis of 3Cpro active site, cleavage site mapping, protein synthesis rate measurement Pathogens Medium 32512928
2023 USP10 deubiquitinase directly interacts with PABPC1 and removes K27/K29-linked ubiquitin from the RRM2 domain of PABPC1. Deubiquitinated PABPC1 more efficiently couples CLK2 mRNA with eIF4G1, increasing CLK2 translation efficiency and promoting PDAC tumor growth. Co-immunoprecipitation, deubiquitination assay, linkage-specific ubiquitination analysis, mRNA-protein interaction assay, RRM2 domain mutants, xenograft models Cancer letters Medium 37757903
2022 De novo variants in the PABP domain of PABPC1 cluster causing developmental delay weaken the interaction between PABPC1 and PAIP2 (confirmed by co-immunoprecipitation). Pabpc1 knockdown in mouse embryo brain decreases neural progenitor cell proliferation; wild-type Pabpc1 rescues this defect, whereas three of four patient variants do not. Exome sequencing, co-immunoprecipitation, in silico modeling, in utero electroporation with rescue experiments Genetics in medicine Medium 35511136
2021 A conserved boxC motif in BTG1 and BTG2 APRO domains is necessary and sufficient for interaction with PABPC1 RRM1, and is required (but not for PRMT1 binding) for stimulation of deadenylation both in cellulo and in vitro. NMR chemical shift perturbation, mutagenesis, pulldown assays, in vitro and in cellulo deadenylation assays RNA biology High 34060423
2020 Crystal structure of the PAM2w variant motif of LARP4B bound to the MLLE domain of PABPC1 was solved, uncovering a new mode of interaction between PAM2 motifs and MLLE domains. Mutational studies in vitro and in vivo validated the structural findings. X-ray crystallography, in vitro binding mutagenesis, in vivo functional assays Biomolecules High 32517187
2012 Expanded ATXN2 (CAG42) sequesters PABPC1 into insolubility in cerebellum of knock-in mice, with decreasing soluble PABPC1 levels correlating with progressive ATXN2 insolubility. This sequestration of PABPC1 into insolubility by expanded ATXN2 was validated in human cell culture. Knock-in mouse model, protein fractionation (soluble vs. insoluble), immunoblot, human cell culture overexpression PLoS genetics Medium 22956915
2001 Yeast Ssa (hsp70) physically interacts with both Sis1 (hsp40) and Pab1 (poly(A)-binding protein) preferentially on translating ribosomes; this interaction is mediated by the variable C-terminal domain of Ssa. Depletion of Ssa dramatically reduces the interaction of Pab1 with the translation initiation factor eIF4G, suggesting Ssa is required for proper Pab1-eIF4G interaction. Subcellular fractionation, co-immunoprecipitation on polysomes, domain mapping, Ssa depletion followed by Pab1-eIF4G interaction assay The Journal of biological chemistry Medium 11279042
2014 In yeast, the Pab1–eRF3 interaction negatively regulates translation termination (deletion of interacting domains produces antisuppression phenotype / decreased readthrough); the Pab1 C-terminal domain role in mRNA stability is independent of eRF3. Yeast eRF3 does not contain a consensus PAM2 motif, indicating a different mode of interaction from metazoan Pab1-eRF3. Domain deletion analysis, genetic interaction (double deletion), readthrough assays, mRNA stability assays in yeast RNA Medium 25411355
2025 PABPC1 preferentially enhances translation efficiency of leukaemogenic mRNAs with long, highly structured 5' UTRs by forming biomolecular condensates/phase separation in CML blast crisis cells. CRISPR-Cas9 screening identified PABPC1 as a driver of CML blast crisis progression, and genetic or pharmacological inhibition of PABPC1 suppresses CML cell proliferation and overcomes TKI resistance with minimal effects on normal haematopoiesis. CRISPR-Cas9 high-throughput screen, biomolecular condensate imaging, polysome profiling, translational efficiency analysis, pharmacological inhibition in murine and human CML models Nature cell biology High 40102686
2025 SUMOylation of PABPC1 under stress conditions promotes stress granule assembly and selectively stabilizes mRNAs enriched in conserved U-rich elements. SUMOylated PABPC1 interacts with TIA1 to form a PABPC1-SUMO-TIA1 complex that recruits U-rich mRNAs into stress granules, protecting them from degradation and facilitating expression of mitophagy-related genes (FUNDC1, BNIP3L). SUMOylation assay, stress granule imaging, transcriptome-wide mRNA stability analysis, co-immunoprecipitation of SUMOylated PABPC1 with TIA1, mitophagy assays Nature communications High 40774970
2025 Yeast Pab1 primarily controls translation initiation in vivo by blocking mRNA decapping and decay: auxin-induced Pab1 degradation reduces mRNA and polysome abundance, and this effect is suppressed by deletion of the decapping enzyme catalytic subunit Dcp2. Assembly of the closed-loop mRNP via PABP–eIF4G interaction is dispensable for wild-type translation of most yeast transcripts at normal mRNA levels. Auxin-inducible degron system for Pab1 depletion, RNA-Seq, Ribo-Seq, dcp2Δ epistasis, polysome profiling Nucleic acids research High 40071937
2022 Acetylation of Pab1 at lysine 131 (K131) reduces stress granule formation upon glucose deprivation and other stressors. Rpd3 deacetylase is the primary enzyme responsible for deacetylation of Pab1-K131. Acetylation mimic at K131 negatively impacts poly(A) RNA binding by Pab1. Acetylation mimetic mutants, stress granule imaging, EMSA (electromobility shift assay) for poly(A) binding, genetic epistasis with rpd3 mutant The Journal of biological chemistry Medium 36572187
2024 PABPC1 interacts with hnRNPA3 and the RNA exosome complex, and knockdown of PABPC1 increases accumulation of C9orf72 GGGGCC repeat RNA and RNA foci to the same extent as hnRNPA3 knockdown. Proximity ligation assays show PABPC1-hnRNPA3 and PABPC1-RNA exosome co-localize preferentially when repeat RNA is present, supporting PABPC1 as a mediator of polyadenylated GGGGCC repeat RNA degradation. APEX2-mediated proximity biotinylation, proximity ligation assay, PABPC1 knockdown with repeat RNA accumulation readout iScience Medium 38444607
2025 EV-D68 3Cpro cleaves PABPC1 to redirect host translation machinery toward viral RNA. Overexpression of PABPC1 inhibits EV-D68 replication and reduces virus-mediated suppression of host translation. This mechanism is conserved in EV-A71 and CV-A16. Viral protease expression, overexpression rescue assay for viral replication and host translation, comparison across multiple enterovirus species PLoS pathogens Medium 40294010
2024 PABPC1 is required for the nuclear retention of newly produced adenosine-rich circRNAs in H9 stem cells: nuclear PABPC1 binds A-rich circRNAs and, in complex with nuclear basket protein TPR, prevents their cytoplasmic export. Decreased nuclear PABPC1 upon neuronal differentiation enables export of A-rich circRNAs (including circRTN4(2,3)) to the cytoplasm, which is required for neurite outgrowth. Nuclear/cytoplasmic fractionation, PABPC1 manipulation (overexpression/knockdown), A-rich motif mutagenesis in circRNAs, neurite outgrowth assay, co-immunoprecipitation with TPR Molecular cell Medium 38838666
2018 PIWIL1 interacts with PABPC1 through its N- and C-terminal domains in an RNA-dependent manner, and binds 3'-UTRs of post-meiotic mRNAs via its N-terminal domain. PIWIL1 augments protein translation together with PABPC1 in the presence of 3'-UTRs of spermiogenic mRNAs, as shown by luciferase reporter assay and polysome profiling. Co-immunoprecipitation domain mapping, luciferase reporter translation assay, sucrose gradient sedimentation (polysome profiling), heterologous cell system Biology of reproduction Medium 29701755
2008 In yeast, neither the poly(A) tail nor Pab1p is required for NMD: mRNAs lacking poly(A) tails containing a PTC are still NMD substrates, and cells lacking Pab1p retain NMD substrate recognition and destabilization activity. This establishes that the poly(A)/Pab1 model for NMD substrate discrimination does not apply in yeast. Poly(A)-tail removal constructs, pab1Δ genetic analysis, NMD reporter assays in yeast Molecular cell High 18206975

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. The EMBO journal 185 17318186
2009 The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Molecular and cellular biology 137 19797087
1997 Yeast Pab1 interacts with Rna15 and participates in the control of the poly(A) tail length in vitro. Molecular and cellular biology 118 9199303
2010 Localization to, and effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on stress granules in Saccharomyces cerevisiae. PloS one 110 20368989
2005 Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export. RNA (New York, N.Y.) 109 15769879
2022 CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer. Cancer letters 102 36436682
2018 Long non-coding RNA SNHG14 induces trastuzumab resistance of breast cancer via regulating PABPC1 expression through H3K27 acetylation. Journal of cellular and molecular medicine 94 30063126
2005 Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export. Genes & development 92 15630021
2011 Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations. Nucleic acids research 86 21989405
2010 Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing. The EMBO journal 83 21063388
2022 PABPC1-induced stabilization of IFI27 mRNA promotes angiogenesis and malignant progression in esophageal squamous cell carcinoma through exosomal miRNA-21-5p. Journal of experimental & clinical cancer research : CR 80 35346324
2012 ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice. PLoS genetics 76 22956915
2017 Poly(A) tail length regulates PABPC1 expression to tune translation in the heart. eLife 74 28653618
2010 Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nature reviews. Molecular cell biology 74 20379206
2016 BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation. Nature communications 69 26912148
2011 Stability of a long noncoding viral RNA depends on a 9-nt core element at the RNA 5' end to interact with viral ORF57 and cellular PABPC1. International journal of biological sciences 64 22043172
2018 circRNA of AR-suppressed PABPC1 91 bp enhances the cytotoxicity of natural killer cells against hepatocellular carcinoma via upregulating UL16 binding protein 1. Oncology letters 63 30655779
2001 The yeast hsp70 homologue Ssa is required for translation and interacts with Sis1 and Pab1 on translating ribosomes. The Journal of biological chemistry 61 11279042
2020 PABPC1-induced stabilization of BDNF-AS inhibits malignant progression of glioblastoma cells through STAU1-mediated decay. Cell death & disease 58 32015336
2015 PABPC1 interacts with AGO2 and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma. Cancer letters 57 26188282
2022 PABPC1--mRNA stability, protein translation and tumorigenesis. Frontiers in oncology 54 36531055
2008 Nonsense-mediated mRNA decay in yeast does not require PAB1 or a poly(A) tail. Molecular cell 54 18206975
2024 Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway. Molecular cancer 50 38532427
2000 Deletion of the PAT1 gene affects translation initiation and suppresses a PAB1 gene deletion in yeast. Molecular and cellular biology 49 10779343
2020 LncRNA SNHG14 promotes hepatocellular carcinoma progression via H3K27 acetylation activated PABPC1 by PTEN signaling. Cell death & disease 47 32811821
2021 E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer. The Journal of experimental medicine 44 34143182
2012 The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic acids research 44 22402495
2007 PAB1 self-association precludes its binding to poly(A), thereby accelerating CCR4 deadenylation in vivo. Molecular and cellular biology 41 17620415
2013 Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate. RNA (New York, N.Y.) 40 23340509
2010 Targeting of the cytosolic poly(A) binding protein PABPC1 to mitochondria causes mitochondrial translation inhibition. Nucleic acids research 40 20144953
2010 PUF3 acceleration of deadenylation in vivo can operate independently of CCR4 activity, possibly involving effects on the PAB1-mRNP structure. Journal of molecular biology 40 20435044
2014 Interaction between the poly(A)-binding protein Pab1 and the eukaryotic release factor eRF3 regulates translation termination but not mRNA decay in Saccharomyces cerevisiae. RNA (New York, N.Y.) 36 25411355
2015 PABPC1 exerts carcinogenesis in gastric carcinoma by targeting miR-34c. International journal of clinical and experimental pathology 33 26097561
2012 Epab and Pabpc1 are differentially expressed during male germ cell development. Reproductive sciences (Thousand Oaks, Calif.) 33 22814100
2021 The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction. Nucleic acids research 32 33332560
2020 The isolated La-module of LARP1 mediates 3' poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1. RNA biology 30 33292040
2018 Extensive Structural Differences of Closely Related 3' mRNA Isoforms: Links to Pab1 Binding and mRNA Stability. Molecular cell 30 30318446
1999 Decapping of stabilized, polyadenylated mRNA in yeast pab1 mutants. Yeast (Chichester, England) 30 10392446
2017 Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells. The Journal of biological chemistry 29 28611064
2018 The Saccharomyces cerevisiae poly (A) binding protein (Pab1): Master regulator of mRNA metabolism and cell physiology. Yeast (Chichester, England) 27 30006991
2023 Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma. Cancer letters 26 37757903
2019 Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy. International journal of molecular sciences 25 31847264
2010 Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast. Genetics 25 20876564
1997 The wheat poly(A)-binding protein functionally complements pab1 in yeast. European journal of biochemistry 23 9030759
2023 The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation. Cell death & disease 22 37225681
2020 Seneca Valley Virus 3Cpro Cleaves PABPC1 to Promote Viral Replication. Pathogens (Basel, Switzerland) 21 32512928
2023 LncRNA WDR11-AS1 Promotes Extracellular Matrix Synthesis in Osteoarthritis by Directly Interacting with RNA-Binding Protein PABPC1 to Stabilize SOX9 Expression. International journal of molecular sciences 20 36614257
2023 PEDV N protein capture protein translation element PABPC1 and eIF4F to promote viral replication. Veterinary microbiology 20 37572396
2024 Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function. Molecular cell 19 38838666
2021 Functional implications of PABPC1 in the development of ovarian cancer. Open medicine (Warsaw, Poland) 19 34027108
2016 The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia. Journal of assisted reproduction and genetics 19 26843391
2002 The pab1 gene of Coprinus cinereus encodes a bifunctional protein for para-aminobenzoic acid (PABA) synthesis: implications for the evolution of fused PABA synthases. Journal of basic microbiology 19 11981873
2001 The chromosomal region containing pab-1, mip, and the A mating type locus of the secondarily homothallic homobasidiomycete Coprinus bilanatus. Current genetics 19 11318102
2024 Helicobacter Pylori-Enhanced hnRNPA2B1 Coordinates with PABPC1 to Promote Non-m6A Translation and Gastric Cancer Progression. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 18 38887155
2014 Epab and Pabpc1 are differentially expressed in the postnatal mouse ovaries. Journal of assisted reproduction and genetics 18 25370180
2015 The Saccharomyces cerevisiae poly(A) binding protein Pab1 as a target for eliciting stress tolerant phenotypes. Scientific reports 16 26658950
2024 LncRNA PRBC induces autophagy to promote breast cancer progression through modulating PABPC1-mediated mRNA stabilization. Oncogene 15 38366145
2017 Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- and RGG-dependent manner. RNA (New York, N.Y.) 15 28986506
2014 Only a subset of the PAB1-mRNP proteome is present in mRNA translation complexes. Protein science : a publication of the Protein Society 15 24838188
2023 PABPC1 promotes cell proliferation and metastasis in pancreatic adenocarcinoma by regulating COL12A1 expression. Immunity, inflammation and disease 14 37506150
2016 Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis. The Journal of reproduction and development 14 26971890
2021 A conserved motif in human BTG1 and BTG2 proteins mediates interaction with the poly(A) binding protein PABPC1 to stimulate mRNA deadenylation. RNA biology 12 34060423
2013 PAB-1, a Caenorhabditis elegans poly(A)-binding protein, regulates mRNA metabolism in germline by interacting with CGH-1 and CAR-1. PloS one 12 24367695
2025 Selective translational control by PABPC1 phase separation regulates blast crisis and therapy resistance in chronic myeloid leukaemia. Nature cell biology 11 40102686
2018 Domain-functional analyses of PIWIL1 and PABPC1 indicate their synergistic roles in protein translation via 3'-UTRs of meiotic mRNAs. Biology of reproduction 11 29701755
2025 PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules. Nature communications 10 40774970
2020 Crystal Structure of a Variant PAM2 Motif of LARP4B Bound to the MLLE Domain of PABPC1. Biomolecules 10 32517187
2017 Express yourself: how PP2A-B55Pab1 helps TORC1 talk to TORC2. Current genetics 10 28643116
2011 The stress granule protein Vgl1 and poly(A)-binding protein Pab1 are required for doxorubicin resistance in the fission yeast Schizosaccharomyces pombe. Biochemical and biophysical research communications 10 22172946
2024 Atherosclerosis-related biomarker PABPC1 predicts pan-cancer events. Stroke and vascular neurology 9 37311641
2022 Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail. The Journal of biological chemistry 9 35307347
2000 The yeast polyadenylate-binding protein (PAB1) gene acts as a disease lesion mimic gene when expressed in plants. Plant molecular biology 9 10794533
2022 Pab1 acetylation at K131 decreases stress granule formation in Saccharomyces cerevisiae. The Journal of biological chemistry 8 36572187
2021 Suppressive effect of platycodin D on bladder cancer through microRNA-129-5p-mediated PABPC1/PI3K/AKT axis inactivation. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 8 33470388
2020 Chromosome-level de novo assembly of Coprinopsis cinerea A43mut B43mut pab1-1 #326 and genetic variant identification of mutants using Nanopore MinION sequencing. Fungal genetics and biology : FG & B 8 33253902
2010 Two mutations in pab-1 encoding poly(A)-binding protein show similar defects in germline stem cell proliferation but different longevity in C. elegans. Molecules and cells 8 20680489
2024 LINC01197 inhibits influenza A virus replication by serving as a PABPC1 decoy. Veterinary research 7 39334466
2022 Structural Model of the Human BTG2-PABPC1 Complex by Combining Mutagenesis, NMR Chemical Shift Perturbation Data and Molecular Docking. Journal of molecular biology 7 35640718
2019 Messenger RNAs of Yeast Virus-Like Elements Contain Non-templated 5' Poly(A) Leaders, and Their Expression Is Independent of eIF4E and Pab1. Frontiers in microbiology 7 31736885
2025 EV-D68 cleaves LARP1 and PABPC1 by 3Cpro to redirect host mRNA translation machinery toward its genomic RNA. PLoS pathogens 6 40294010
2024 PABPC1 mediates degradation of C9orf72-FTLD/ALS GGGGCC repeat RNA. iScience 6 38444607
2024 Circ_PABPC1 promotes the malignancy of gastric cancer through interacting with ILK to activate NF-κB pathway. Experimental cell research 6 38688434
2022 De novo variants in the PABP domain of PABPC1 lead to developmental delay. Genetics in medicine : official journal of the American College of Medical Genetics 6 35511136
2019 Amorphous silica nanoparticles induce tumorigenesis via regulating ATP5H/SOD1-related oxidative stress, oxidative phosphorylation and EIF4G2/PABPC1-associated translational initiation. PeerJ 6 30863671
1993 Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization. Genomics 6 8432538
2024 BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1. Molecular carcinogenesis 5 38197534
2024 PABPC1 silencing inhibits pancreatic cancer cell proliferation and EMT, and induces apoptosis via PI3K/AKT pathway. Cytotechnology 5 38736728
2025 circFOXK2 Stabilizes STMN1 mRNA via PABPC1 to Promote the Progression of NSCLC. Cancer medicine 4 40013670
2025 Multivalent interactions with CCR4-NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin. Nature communications 4 40804313
2024 Cellular RNA-binding proteins LARP4 and PABPC1 synergistically facilitate viral translation of coronavirus PEDV. Veterinary microbiology 4 39182469
2024 LINC00882, transcriptionally activated by CEBP-β and post-transcriptionally stabilized by METTL14-mediated m6A modification, exerts tumorigenesis by promoting PABPC1-mediated stabilization of ELK3 mRNA. Oncogene 4 39551868
2021 PABPC1 Enables Cells with the Suspension Cultivation Feature. ACS synthetic biology 4 33502842
2025 LINC00467 promotes non-small-cell lung cancer progression by regulating PABPC1 stability which accompanied by changes in Wnt/β-catenin pathway activity. International journal of biological macromolecules 3 40782856
2024 Pleiotropic effects of PAB1 deletion: Extensive changes in the yeast proteome, transcriptome, and translatome. PLoS genetics 3 39236083
2025 Yeast poly(A)-binding protein (Pab1) controls translation initiation in vivo primarily by blocking mRNA decapping and decay. Nucleic acids research 2 40071937
2023 ALK-positive Large B-Cell Lymphoma With Multiple Epithelial Antigen Expression and PABPC1::ALK Fusion : A Novel Molecular Alteration. The American journal of surgical pathology 2 37326123
2022 eIF4G1 N-terminal intrinsically disordered domain is a multi-docking station for RNA, Pab1, Pub1, and self-assembly. Frontiers in molecular biosciences 2 36213119
2025 Targeting PABPC1: A therapeutic strategy of natural Ganoderma meroterpenoid LZ22 against triple-negative breast cancer proliferation. Pharmacological research 1 41125141
2024 Yeast poly(A)-binding protein (Pab1) controls translation initiation in vivo primarily by blocking mRNA decapping and decay. bioRxiv : the preprint server for biology 1 38903079
2024 PABPC1 Silencing Inhibits Gastric Cancer Cell Proliferation, Metastasis, and EMT Via the PI3K/AKT Pathway. Biochemical genetics 1 39729165

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