Affinage

USP10

Ubiquitin carboxyl-terminal hydrolase 10 · UniProt Q14694

Length
798 aa
Mass
87.1 kDa
Annotated
2026-04-28
100 papers in source corpus 51 papers cited in narrative 51 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

USP10 is a ubiquitin-specific protease that deubiquitinates a remarkably broad range of substrates to regulate p53-dependent DNA damage responses, NF-κB signaling, AMPK-mediated energy sensing, Wnt/β-catenin suppression, Notch signaling, autophagy, ribosome quality control, and cytokinesis. Its catalytic activity removes K48-, K63-, K11-, and K27/K29-linked ubiquitin chains from substrates including p53, CFTR, SIRT6, AMPKα, NICD1, MSH2, ANLN, PTEN, LC3B, and Axin1, thereby controlling their stability, localization, or enzymatic activity (PMID:20096447, PMID:19398555, PMID:24332849, PMID:26876938, PMID:30975888, PMID:26975374, PMID:36526897, PMID:34416231, PMID:33577797, PMID:37611590). USP10 localization and activity are dynamically regulated by signal-dependent phosphorylation—ATM phosphorylates Thr42/Ser337 to drive nuclear translocation after DNA damage, AMPK phosphorylates Ser76 to create a feedforward activation loop under energy stress, and AKT phosphorylates T674 to promote nuclear import for AID stabilization in B cells (PMID:20096447, PMID:26876938, PMID:34983926). Beyond its catalytic role, USP10 functions as a structural scaffold—binding both Axin1 and β-catenin to promote phase separation-mediated β-catenin destruction independent of deubiquitinase activity—and partners with G3BP1/G3BP2 to regulate stress granule dynamics and rescue ubiquitinated 40S ribosomal subunits from lysosomal degradation (PMID:37611590, PMID:27022092, PMID:31981475).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2001 High

    Identification of G3BP as a direct binding partner that inhibits USP10 deubiquitinase activity established that USP10 enzymatic output is subject to protein–protein regulation, not just substrate availability.

    Evidence Yeast two-hybrid, reciprocal co-IP, in vitro DUB inhibition assay

    PMID:11439350

    Open questions at the time
    • Structural basis of G3BP inhibition unknown
    • In vivo relevance of G3BP-mediated inhibition not tested
    • Other regulators of USP10 catalytic activity not explored
  2. 2005 Medium

    Demonstration that USP10 is recruited to androgen receptor transcriptional complexes and stimulates AR-dependent transcription in a catalytic-activity-dependent manner provided the first link between USP10 and nuclear gene regulation.

    Evidence Affinity purification from nuclear extracts, GST pull-down, reporter gene assay with catalytically inactive mutant

    PMID:16368182

    Open questions at the time
    • Direct AR deubiquitination not demonstrated
    • Relevant ubiquitinated substrate in AR complexes unidentified
    • Single lab study
  3. 2009 High

    Discovery that USP10 localizes to early endosomes and deubiquitinates CFTR to promote its recycling to the plasma membrane established USP10 as a regulator of membrane protein trafficking, distinct from nuclear functions.

    Evidence Activity-based DUB screen, dominant-negative C424A mutant, subcellular fractionation, functional chloride secretion assay in airway epithelial cells

    PMID:19398555

    Open questions at the time
    • Mechanism of USP10 endosomal recruitment unknown
    • Whether USP10 regulates other endosomal cargo not addressed
  4. 2010 High

    The landmark finding that USP10 deubiquitinates p53 and that ATM-mediated phosphorylation at Thr42/Ser337 stabilizes USP10 and triggers its nuclear translocation after DNA damage established USP10 as a signal-responsive DUB central to the DNA damage–p53 axis.

    Evidence In vitro DUB assay, ATM kinase assay, phosphomimetic mutants, subcellular fractionation, live imaging in human cells

    PMID:20096447

    Open questions at the time
    • Structural basis of ATM-dependent conformational change unknown
    • Whether other kinases also regulate USP10 translocation not explored at this time
  5. 2011 High

    Two studies expanded USP10 substrate repertoire: Beclin1 was shown to control USP10/USP13 DUB activity toward Vps34 complexes linking autophagy to p53 regulation, and USP10 was found to deubiquitinate histone variant H2A.Z to enable androgen-responsive transcriptional activation—demonstrating both cytoplasmic and chromatin-level functions.

    Evidence Small-molecule inhibitor (Spautin-1) screen and DUB assay (Beclin1–Vps34); in vitro deubiquitylation assay with ChIP at PSA/KLK3 loci (H2A.Z)

    PMID:21245042 PMID:21962518

    Open questions at the time
    • How Beclin1 modulates USP10 catalytic activity mechanistically unclear
    • Whether H2A.Z deubiquitination is AR-locus-specific or genome-wide unknown
  6. 2013 High

    USP10 was shown to stabilize SIRT6 by opposing its ubiquitin-dependent degradation (inhibiting c-Myc transcriptional programs), and separately to remove linear polyubiquitin from NEMO via MCPIP1 to suppress genotoxic NF-κB activation—revealing USP10 as a node connecting metabolism, chromatin, and inflammatory signaling.

    Evidence Proteomic co-IP/MS for SIRT6; reciprocal co-IP with ubiquitin chain-type specificity for NEMO; NF-κB reporter and epistasis

    PMID:24270572 PMID:24332849

    Open questions at the time
    • How USP10 distinguishes linear from K48/K63 chains on NEMO not structurally resolved
    • Tissue-specific relevance of USP10–SIRT6 not yet tested in vivo
  7. 2016 High

    Multiple 2016 studies established USP10 as a signal-regulated hub: AMPK phosphorylates USP10-Ser76 creating a feedforward loop for AMPK activation; G3BP1-Caprin1-USP10 complexes were shown to regulate stress granule condensation through competitive binding; USP10 opposes RNF168-mediated TOP2α ubiquitylation; and USP10 stabilizes MSH2 for mismatch repair competence.

    Evidence In vitro kinase/DUB reconstitution and phosphomimetic mutants (AMPK); G3BP1/2 double-KO rescue with structure–function mutants and live imaging (SG); decatenation assay in RNF168-deficient cells (TOP2α); in vitro DUB and rescue experiments (MSH2)

    PMID:26876938 PMID:26975374 PMID:27022092 PMID:27558965

    Open questions at the time
    • Structural basis of AMPK-USP10 feedforward unknown
    • Whether Caprin1 and USP10 compete for the same G3BP binding site requires structural data
    • In vivo relevance of USP10–TOP2α axis not tested
  8. 2017 High

    USP10 was identified as the critical DUB stabilizing oncogenic FLT3 in AML, and separately its deubiquitination of integrins β1/β5 was linked to TGFβ-dependent fibrotic remodeling—broadening USP10's disease relevance to leukemia and fibrosis.

    Evidence DUB inhibitor library screen with target deconvolution across AML cell lines, patient samples, and mouse models (FLT3); in vitro DUB assay with recombinant USP10 and ex vivo corneal culture (integrins)

    PMID:28851806 PMID:28967922

    Open questions at the time
    • FLT3 ubiquitination site(s) targeted by USP10 not mapped
    • Whether USP10 inhibition affects wild-type FLT3 signaling in normal hematopoiesis unclear
  9. 2018 High

    Studies revealed USP10's roles in oncogene-induced senescence (deubiquitinating p14ARF downstream of c-Myc), hepatic metabolism (SIRT6 stabilization preventing steatosis via tissue-specific knockout), and protein aggregation (promoting p62-dependent aggresome formation with co-localization in Parkinson disease Lewy bodies).

    Evidence USP10-null MEFs with senescence assays (p14ARF); hepatocyte-specific USP10 KO mice with metabolic phenotyping and SIRT6 rescue (hepatic steatosis); co-IP plus proteasome activity and PD brain immunohistochemistry (aggresomes)

    PMID:29472714 PMID:29698567 PMID:30469013

    Open questions at the time
    • Mechanism by which USP10 distinguishes p14ARF from p53 in the same cell unclear
    • Whether aggresome function is DUB-dependent or scaffold-dependent not resolved
  10. 2019 High

    USP10's substrate portfolio expanded further: stabilization of NICD1 controlling angiogenesis (endothelial-specific KO in mice), KLF4 suppressing Kras-driven lung adenocarcinoma, and PTEN opposing PI3K signaling—and its activity was shown to be modulated by competitive displacement (TRAF4 blocking p53 access).

    Evidence Endothelial-specific Usp10 deletion with sprouting assay (NICD1); USP10 KO × KrasG12D mouse model (KLF4); co-IP, rescue epistasis (PTEN); competition binding assay (TRAF4–p53)

    PMID:28852924 PMID:30940456 PMID:30975888 PMID:31748695

    Open questions at the time
    • How USP10 specificity toward >30 substrates is achieved remains a central unanswered question
    • Relative substrate priority under physiological conditions unknown
  11. 2020 High

    USP10 was shown to deubiquitinate and stabilize G3BP1-associated stalled 40S ribosomal proteins (RPS2, RPS3, RPS10) to rescue them from lysosomal degradation during ribosome quality control, and separately to stabilize YAP/TAZ in hepatocellular carcinoma.

    Evidence USP10/G3BP1 KO with RPS3-K214R rescue and ribosome stoichiometry analysis (ribosome QC); DUB siRNA library screen with in vivo tumor models (YAP/TAZ)

    PMID:31981475 PMID:32217697

    Open questions at the time
    • How G3BP1 directs USP10 specifically to stalled 40S rather than translating ribosomes unknown
    • Whether YAP/TAZ deubiquitination occurs in normal tissue homeostasis unclear
  12. 2021 High

    Two studies addressed distinct USP10 functions: a CRISPR screen identified USP10 as a deubiquitinase for LC3B that maintains autophagy flux, and biochemical work demonstrated USP10 removes K63-linked ubiquitin from PTEN to restore its phosphatase activity—extending USP10 regulation to non-degradative ubiquitin signals.

    Evidence CRISPR-Cas9 KO screen with autophagy flux assays (LC3B); K63-linkage-specific DUB assay with C424A mutant and PIP3 measurement (PTEN)

    PMID:33577797 PMID:34416231

    Open questions at the time
    • Whether LC3B deubiquitination is selective for specific autophagy pathways unknown
    • Structural basis for USP10 recognition of K63 vs. K48 chains unresolved
  13. 2022 High

    USP10 was found to stabilize nuclear AID via AKT-mediated phosphorylation at T674 (driving nuclear import), linking BCR/TLR signaling to class switch recombination in B cells, and to stabilize ANLN by removing K11/K63 chains to promote cytokinesis—demonstrating yet another phosphorylation-dependent regulatory mode.

    Evidence B cell-specific USP10 KO with vaccination model and nuclear fractionation (AID); chain-type-specific DUB assay with cytokinesis readout and pharmacological validation (ANLN)

    PMID:34983926 PMID:36526897

    Open questions at the time
    • Whether AKT-T674 phosphorylation affects substrate selectivity beyond AID unknown
    • How USP10 opposes APC/C-Cdh1 at the contractile ring spatially is unclear
  14. 2023 High

    A critical conceptual advance: USP10 was shown to suppress Wnt/β-catenin signaling through both enzymatic (K48-deubiquitination of Axin1) and non-enzymatic (scaffolding Axin1–β-catenin phase separation) mechanisms, with AMPK phosphorylation potentiating both; additional substrates (PABPC1, RUNX1, NOTCH1/N1DARP competition, PARP1, MOF) were identified.

    Evidence Catalytically inactive USP10 mutant distinguishing enzymatic vs. scaffold roles; phase separation assay; AMPK kinase assay with phosphomimetic mutants; specific ubiquitin linkage/site mapping across multiple substrates

    PMID:36949071 PMID:37611590 PMID:37714834 PMID:37757903 PMID:37838281 PMID:37873736 PMID:38317006

    Open questions at the time
    • No high-resolution structure of full-length USP10 or USP10–substrate complex exists
    • How scaffolding and catalytic functions are coordinated in the same cell is unknown
    • Relative contribution of enzymatic vs. non-enzymatic Wnt suppression in vivo not quantified
  15. 2024 Medium

    DCAF7 was identified as a scaffold facilitating USP10-mediated K48-linked deubiquitination of G3BP1 at Lys76, closing the loop on the G3BP1–USP10 regulatory circuit: USP10 both regulates and is regulated by G3BP1, and a third-party scaffold modulates this interaction.

    Evidence Co-IP, K48-linkage and site-specific ubiquitination assay, SG formation assay, cisplatin resistance in vitro and in vivo

    PMID:38973296

    Open questions at the time
    • Whether DCAF7 scaffolding is stress-specific or constitutive unknown
    • Single lab study awaits independent replication

Open questions

Synthesis pass · forward-looking unresolved questions
  • Despite extensive substrate cataloguing, no high-resolution structure of USP10 exists, the rules governing substrate selectivity among its >30 identified targets are unknown, and the relative physiological importance of its enzymatic versus scaffolding functions remains unquantified.
  • No crystal or cryo-EM structure of full-length USP10
  • No systematic analysis of substrate competition or prioritization in a single cell type
  • In vivo phenotypes of catalytic-dead knock-in (separating enzymatic from scaffold roles) not reported

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 27 GO:0016787 hydrolase activity 6 GO:0060090 molecular adaptor activity 2
Localization
GO:0005634 nucleus 4 GO:0005829 cytosol 3 GO:0005694 chromosome 2 GO:0005768 endosome 1
Pathway
R-HSA-162582 Signal Transduction 7 R-HSA-168256 Immune System 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-73894 DNA Repair 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1640170 Cell Cycle 2 R-HSA-9612973 Autophagy 2
Partners
BECN1DCAF7G3BP1G3BP2MCPIP1NEMOSIRT6TANK
Complex memberships
G3BP1-Caprin1-USP10TANK-MCPIP1-USP10

Evidence

Reading pass · 51 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 USP10 is a cytoplasmic deubiquitinase that deubiquitinates p53, reversing Mdm2-induced p53 nuclear export and degradation. After DNA damage, ATM phosphorylates USP10 at Thr42 and Ser337, stabilizing USP10 and causing a fraction to translocate to the nucleus to activate p53. Co-immunoprecipitation, in vitro deubiquitination assay, ATM kinase assay, phosphomimetic mutants, subcellular fractionation, live imaging Cell High 20096447
2001 G3BP (Ras-GAP SH3 domain binding protein) physically interacts with USP10 and inhibits USP10's ability to disassemble ubiquitin chains; G3BP is not a substrate of USP10 but rather a modulator of its activity. Yeast two-hybrid, in vitro binding assay, co-immunoprecipitation, in vitro deubiquitination assay Oncogene High 11439350
2011 Beclin1 controls the deubiquitinating activities of USP10 and USP13 toward the Beclin1 subunit of Vps34 PI3 kinase complexes; USP10 in turn mediates deubiquitination of p53, linking Beclin1 to control of p53 levels. Spautin-1 inhibits USP10/USP13 causing Vps34 complex degradation. Small-molecule inhibitor screen, co-immunoprecipitation, in vitro DUB assay, genetic knockdown, ubiquitination assay Cell High 21962518
2011 USP10 directly deubiquitylates the histone variant H2A.Z in vitro and in vivo, and both USP10 and H2A.Z are required for transcriptional activation of androgen receptor-regulated genes (PSA and KLK3); USP10 knockdown elevates mono-ubiquitylated H2A.Z levels and blocks hormone-induced deubiquitylation at these gene loci. In vitro deubiquitylation assay, siRNA knockdown, ChIP, sequential ChIP, immunoprecipitation Nucleic acids research High 21245042
2009 USP10 localizes to early endosomes in airway epithelial cells and deubiquitinates CFTR, promoting its endocytic recycling to the apical membrane; dominant-negative USP10-C424A increases ubiquitinated CFTR and its lysosomal degradation, reducing CFTR-mediated chloride secretion. Activity-based chemical DUB screen, siRNA knockdown, dominant-negative mutant (C424A), immunofluorescence/subcellular fractionation, chloride secretion assay, co-immunoprecipitation The Journal of biological chemistry High 19398555
2013 USP10 deubiquitinates and stabilizes SIRT6, antagonizing c-Myc transcriptional activity and inhibiting cell-cycle progression; USP10 suppresses SIRT6 ubiquitination to protect it from proteasomal degradation. Proteomic co-immunoprecipitation (mass spectrometry), ubiquitination assay, knockdown/overexpression, cell-cycle analysis Cell reports High 24332849
2016 USP10 removes ubiquitin from AMPKα to facilitate its phosphorylation by LKB1, thereby activating AMPK; under energy stress, AMPK reciprocally phosphorylates USP10 at Ser76 to enhance its activity, forming a feedforward loop amplifying AMPK activation. Co-immunoprecipitation, in vitro DUB assay, kinase assay, phosphomimetic mutants, AMPK activity assay, metabolic phenotyping Molecular cell High 26876938
2016 G3BP-Caprin1-USP10 complexes associate with 40S ribosomal subunits; Caprin1 binding to G3BP promotes stress granule (SG) formation, while USP10 binding to G3BP inhibits SG formation. Phosphomimetic G3BP1-S149E and the F33W mutant (unable to bind Caprin1 or USP10) defined the regulatory mechanism of SG condensation. G3BP1/2 double-knockout rescue experiments, G3BP1 point mutants (S149E, F33W), co-immunoprecipitation, live-cell imaging of SG formation The Journal of cell biology High 27022092
2016 G3BP1-family-USP10 complexes deubiquitinate RPS2, RPS3, and RPS10 on stalled 40S ribosomal subunits to rescue them from lysosomal degradation during ribosome-associated quality control; USP10 or G3BP1-family knockout increases lysosomal ribosomal degradation and perturbs ribosomal subunit stoichiometry. USP10/G3BP1 knockout, ubiquitination assay, K214R RPS3 rescue, ribosome profiling/stoichiometry analysis, lysosomal inhibition assay Molecular cell High 31981475
2017 USP10 is the critical deubiquitinase required to stabilize oncogenic FLT3; inhibition of USP10 induces proteasome-mediated FLT3 degradation and shows efficacy in preclinical AML models. DUB inhibitor library phenotypic screen, target deconvolution, co-immunoprecipitation, ubiquitination assay, cell line/primary patient/mouse model studies Nature chemical biology High 28967922
2013 USP10 interacts with NEMO via MCPIP1 upon genotoxic stress and removes linear polyubiquitin chains from NEMO, inhibiting IKK/NF-κB activation; this constitutes a negative feedback mechanism for genotoxic NF-κB signaling. Co-immunoprecipitation, ubiquitination assay, NF-κB reporter, siRNA knockdown, apoptosis assay The EMBO journal High 24270572
2015 TANK forms a complex with MCPIP1 and USP10, which is essential for USP10-dependent deubiquitination of TRAF6 and resolution of genotoxic NF-κB activation; the TANK-MCPIP1-USP10 complex also decreases TRAF6 ubiquitination in response to IL-1β or LPS. Co-immunoprecipitation, CRISPR/Cas9 deletion, ubiquitination assay, NF-κB reporter, cytokine ELISA The Journal of biological chemistry High 25861989
2019 USP10 interacts with NOTCH1 intracellular domain (NICD1) and slows its ubiquitin-dependent turnover; inactivation of USP10 reduces NICD1 abundance and Notch target gene expression in endothelial cells; endothelial-specific Usp10 deletion increases vessel sprouting in mice. Co-immunoprecipitation, ubiquitination assay, shRNA/genetic knockout, endothelial-specific mouse model, angiogenic sprouting assay Science High 30975888
2016 RNF168 mediates ubiquitylation of TOP2α to enhance its decatenation activity; USP10 acts as the opposing deubiquitylase that negatively regulates TOP2α ubiquitylation and restrains its chromatin association. Co-immunoprecipitation, ubiquitination assay, decatenation assay, RNF168-deficient cells, mitotic analysis Nature communications High 27558965
2016 USP10 deubiquitinates and stabilizes MSH2 in vitro and in vivo; USP10 knockdown in lung cancer cells increases cell survival and decreases apoptosis after DNA-methylating agent treatment, phenotypes rescued by ectopic MSH2 expression. Co-immunoprecipitation, in vitro DUB assay, siRNA knockdown, rescue experiment, mismatch repair activity assay, cell survival assay The Journal of biological chemistry High 26975374
2020 USP10 directly interacts with and stabilizes YAP/TAZ by reverting their proteolytic ubiquitination; USP10 depletion enhances polyubiquitination of YAP/TAZ, promoting their proteasomal degradation and arresting hepatocellular carcinoma proliferation. DUB siRNA library screen, co-immunoprecipitation, ubiquitination assay, shRNA knockdown, in vitro and in vivo tumor models Cancer research High 32217697
2019 USP10 deubiquitinates and stabilizes KLF4; loss of USP10 in mice accelerates KrasG12D-driven lung adenocarcinoma; KLF4 in turn activates TIMP3 transcription by binding its promoter. DUB screen, co-immunoprecipitation, ubiquitination assay, USP10 knockout mouse model, ChIP, in vivo tumorigenesis Cell death and differentiation High 31748695
2005 USP10 is part of DNA-bound androgen receptor (AR) complexes; it interacts with AR via GST pull-down and stimulates AR transcriptional activity in a manner dependent on its enzymatic activity (catalytically inactive USP10 fails to stimulate). Affinity purification from nuclear extracts, GST pull-down, siRNA knockdown, reporter gene transactivation assay with wild-type vs. catalytically inactive USP10 Molecular and cellular endocrinology Medium 16368182
2017 USP10 deubiquitinates integrin β1 and β5, protecting them from degradation; loss of USP10 decreases αv/β1/β5 protein levels, activates endogenous TGFβ, and induces fibrotic markers in corneal myofibroblasts; recombinant USP10 removes ubiquitin from integrin subunits in vitro. Genetic screen, siRNA knockdown, overexpression, in vitro DUB assay with recombinant USP10, TGFβ signaling assay, ex vivo cornea organ culture Journal of cell science High 28851806
2018 USP10 interacts with, deubiquitinates, and stabilizes HDAC6; the USP10-HDAC6 axis confers cisplatin resistance in p53-null NSCLC cells, as reintroduction of either USP10 or HDAC6 into USP10-knockdown cells restores resistance. Co-immunoprecipitation, ubiquitination assay, siRNA/shRNA knockdown, rescue experiment, in vivo xenograft Cell death & disease High 32382008
2019 USP10 deubiquitinates and stabilizes Smad4 by cleaving its proteolytic ubiquitination; USP10 suppression (shRNA or spautin-1) inhibits HCC cell migration, rescued by Smad4 reconstitution. DUB siRNA library screen, co-immunoprecipitation, ubiquitination assay, rescue experiment, migration assay Molecular oncology Medium 31721429
2019 USP10 deubiquitinates and stabilizes SKP2; SKP2 mediates K63-linked ubiquitination and activation of Bcr-Abl; thus USP10 amplifies Bcr-Abl activity via the USP10/SKP2/Bcr-Abl axis in CML cells. Co-immunoprecipitation, ubiquitination assay (K63-linked specificity), siRNA knockdown, pharmacological USP10 inhibition, primary CML cell validation Cell discovery Medium 31044085
2014 USP10 directly inhibits ubiquitination of T-bet and increases T-bet protein stability; quercetin inhibits USP10 to promote T-bet proteasomal degradation. Co-immunoprecipitation, ubiquitination assay, overexpression, pharmacological inhibition with quercetin Biochemical and biophysical research communications Medium 24845384
2018 c-Myc induces USP10 transcription; USP10 in turn deubiquitinates p14ARF, preventing its proteasomal degradation and enabling oncogene-induced senescence; USP10-null MEFs bypass c-Myc-induced senescence via p14ARF destabilization. Genetic knockout (USP10-null MEFs), siRNA knockdown, ubiquitination assay, senescence assays (SA-β-gal, proliferation), rescue experiment Cell death and differentiation High 29472714
2013 HTLV-1 Tax interacts with USP10 in HTLV-1-infected T cells and inhibits arsenic-induced stress granule formation, thereby stimulating ROS production and augmenting ROS-dependent apoptosis. Co-immunoprecipitation, stress granule formation assay, ROS measurement, apoptosis assay, viral infection model Blood Medium 23775713
2018 USP10 interacts with p62 and augments p62-dependent ubiquitinated protein aggregation and aggresome formation, inhibiting apoptosis; USP10/p62-induced protein aggregates inhibit proteasome activity, increasing ubiquitinated proteins and promoting aggresome formation; USP10 was colocalized with α-synuclein in Lewy bodies in Parkinson disease brain. Co-immunoprecipitation, aggresome formation assay, proteasome activity assay, immunohistochemistry of PD brain tissue, cell death assay iScience Medium 30469013
2019 USP10 is a critical factor for Tau/TIA1-positive stress granule formation; USP10 depletion severely attenuates TIA1/Tau-positive SG formation in neuronal cells; USP10 overexpression without stress induces TIA1/Tau/USP10-positive SGs in a deubiquitinase-independent manner. siRNA knockdown, overexpression of wild-type and DUB-inactive USP10, immunofluorescence SG assay, neuronal cell model Scientific reports Medium 31332267
2021 USP10 deubiquitinates LC3B to increase LC3B-I and LC3B-II levels and autophagic activity; USP10 was identified in a CRISPR-Cas9 knockout screen; USP10 silencing reduces LC3B through increased ubiquitination and proteasomal degradation, impairing autophagy receptor (SQSTM1/NBR1) degradation. CRISPR-Cas9 knockout screen, siRNA silencing, ubiquitination assay, autophagy flux assay (SQSTM1/NBR1 degradation), aggresome assay The Journal of biological chemistry High 33577797
2018 USP10 interacts with and deubiquitinates Raf-1, stabilizing its protein level (not mRNA), and activates the Raf-1/MEK/ERK pathway to promote endometrial stromal cell proliferation and migration; MEK inhibitor PD-98059 blocks USP10 overexpression effects. Co-immunoprecipitation, ubiquitination assay, siRNA/overexpression, MEK inhibitor epistasis, cell proliferation/migration/apoptosis assays American journal of physiology. Cell physiology Medium 30281322
2017 Crystal structure of UbV.7.2 (ubiquitin variant targeting USP7) was solved and rationalizes enhanced affinity/specificity; UbV inhibitors targeting USP10 bind and inhibit its deubiquitination activity, validating USP10's catalytic site as druggable. Phage-displayed ubiquitin variant library, crystal structure determination (UbV-USP7), in vitro DUB inhibition assay, cell death assay Journal of molecular biology Medium 28587923
2022 USP10 interacts with and deubiquitinates ANLN (anillin), removing K11- and K63-linked ubiquitin chains, preventing APC/C-Cdh1-mediated degradation; USP10 promotes contractile ring assembly and cytokinesis by stabilizing ANLN; F806 selectively targets USP10 catalytic activity to promote ANLN degradation. Co-immunoprecipitation, ubiquitination assay (chain-type specific), siRNA/shRNA knockdown, cytokinesis assay, pharmacological inhibition (F806), APC/C complex analysis Cell death and differentiation High 36526897
2023 USP10 binds to Axin1 via conserved motifs and stabilizes Axin1 through K48-linked deubiquitination; USP10 also physically tethers Axin1 and β-catenin to promote phase separation for β-catenin suppression, independent of enzymatic activity; both mechanisms antagonize Wnt/β-catenin signaling. Co-immunoprecipitation, ubiquitination assay (K48-linked), catalytically inactive USP10 mutant, phase separation assay, genetic knockout, developmental and intestinal homeostasis phenotypes Cell chemical biology High 37611590
2023 AMPK-mediated phosphorylation of USP10 potentiates deubiquitination and stabilization of Axin1, and also strengthens USP10-β-catenin binding to promote β-catenin phase transition, establishing a crosstalk between LKB1/AMPK and Wnt/β-catenin signaling. Co-immunoprecipitation, ubiquitination assay, AMPK kinase assay, phosphomimetic mutants, phase separation assay, colorectal cancer growth assay FEBS letters Medium 37873736
2019 USP10 deubiquitinates and stabilizes PTEN via direct interaction; USP10 knockdown promotes tumor growth and invasion, and the pro-cancerous effect of USP10 deficiency is abolished by PTEN re-introduction. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, rescue experiment, in vitro and in vivo tumor assays Molecular and cellular biochemistry Medium 28852924
2021 USP10 removes K63-linked polyubiquitination of PTEN mediated by TRIM25, restoring PTEN phosphatase activity and reducing PIP3 production; catalytically inactive USP10-C424A fails to remove this ubiquitination, establishing the enzymatic requirement. Co-immunoprecipitation, ubiquitination assay (K63-linked specific), catalytic mutant (C424A), PIP3 measurement, AKT/mTOR signaling assay, NSCLC cell proliferation assay The Journal of biological chemistry High 34416231
2018 USP10 interacts with and stabilizes SIRT6, inhibiting its ubiquitination and degradation; USP10-dependent SIRT6 stabilization suppresses hepatic steatosis, insulin resistance, and inflammation; SIRT6 overexpression rescues the metabolic dysfunction caused by USP10 deficiency. Co-immunoprecipitation, ubiquitination assay, hepatocyte-specific USP10 knockout and overexpression mouse models, rescue by SIRT6 overexpression, metabolic phenotyping Hepatology High 29698567
2019 TRAF4 interacts with USP10 and blocks p53's access to USP10, resulting in p53 destabilization and promotion of fibroblast proliferation in keloids; TRAF4 acts independently of its E3 ligase activity in this mechanism. Co-immunoprecipitation, competition binding assay, ubiquitination assay, siRNA knockdown, p53 stability assay, proliferation assay The Journal of investigative dermatology Medium 30940456
2020 USP10 is required for stabilization of SYK; USP10 inhibition induces SYK degradation and potentiates anti-leukemic effects of FLT3 inhibition. Co-immunoprecipitation, ubiquitination assay, pharmacological USP10 inhibitors, cell viability assay, AML cell models British journal of cancer Medium 32015510
2019 USP10 interacts with and deubiquitinates NLRP7 in colorectal cancer cells; K379 is an important lysine acceptor site mediating NLRP7 ubiquitination; USP10 promotes tumor progression and M2 macrophage polarization through NLRP7 stabilization. Immunoprecipitation/mass spectrometry, co-immunoprecipitation, ubiquitination assay, lysine mutagenesis, in vitro and in vivo tumor models, macrophage polarization assay Journal of experimental & clinical cancer research Medium 33838681
2022 USP10 stabilizes nuclear AID (activation-induced cytidine deaminase) by deubiquitination; USP10 translocates to the nucleus after AKT-mediated phosphorylation at T674 within the NLS domain, triggered by synergistic BCR and TLR1/2 signals; USP10 deficiency in B cells decreases AID protein levels and reduces neutralizing antibody production after vaccination. Co-immunoprecipitation, ubiquitination assay, AKT phosphorylation assay, nuclear fractionation, B cell-specific USP10 knockout, vaccine immunization model Signal transduction and targeted therapy High 34983926
2023 MEK-ERK signaling phosphorylates USP10 at Ser236, impairing its interaction with ZEB1 and enabling ZEB1 protein stabilization; conversely, MEK-ERK inhibition enhances the USP10-ZEB1 interaction, promoting ZEB1 proteasomal degradation and suppressing metastasis. Co-immunoprecipitation, ubiquitination assay, phosphomimetic/phospho-null mutants, MEK inhibitor treatment, mouse tail-vein metastasis model Molecular cancer research Medium 36940483
2023 USP10 interacts with and deubiquitinates PABPC1, reducing its K27/29-linked ubiquitination; deubiquitinated PABPC1 couples more CLK2 mRNA and eIF4G1, increasing CLK2 translation efficiency and promoting pancreatic cancer progression. Co-immunoprecipitation, deubiquitination assay (K27/29-linked specific), polysome profiling/translation assay, siRNA knockdown, xenograft/PDX models Cancer letters Medium 37757903
2023 USP10 deubiquitinates and stabilizes RUNX1, promoting proneural-to-mesenchymal transition in glioblastoma; USP10 inhibitor spautin-1 induces RUNX1 degradation and inhibits mesenchymal properties in vitro and in vivo. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, overexpression, in vivo xenograft, pharmacological inhibition Cell death & disease Medium 36949071
2023 USP10 interacts with NOTCH1 intracellular domain (N1ICD) to stabilize it; the microprotein N1DARP competitively disrupts USP10-N1ICD interaction, promoting K11- and K48-linked polyubiquitination and proteasomal degradation of N1ICD, suppressing Notch1 signaling and chemoresistance in pancreatic cancer. Co-immunoprecipitation, ubiquitination assay (K11/K48 specificity), competitive binding assay, pancreatic cancer organoids, KPC mouse model, stapled peptide pharmacology Cell discovery High 37714834
2019 USP10 interacts with TAK1 and protects against cerebral ischemia-reperfusion injury; USP10 knockout mice show elevated NF-κB and JNK-MAPK signaling, increased infarct size, and enhanced apoptosis after cerebral I/R. USP10 knockout mouse model, co-immunoprecipitation, NF-κB signaling assay, infarct volume measurement, apoptosis assay Biochemical and biophysical research communications Medium 31301769
2021 USP10 stimulates Nrf2 antioxidant transcriptional activity in neuronal cells by interacting with p62, increasing p62 phosphorylation, enhancing p62-Keap1 interaction, and augmenting Nrf2 translation; this reduces dopamine-induced ROS production and apoptosis. Co-immunoprecipitation, phosphorylation assay, Nrf2 reporter assay, ROS measurement, apoptosis assay, translation assay The Journal of biological chemistry Medium 34838592
2023 AEG-1 recruits USP10 to remove K48-linked polyubiquitin chains at Lys425 of PARP1, stabilizing PARP1 and facilitating homologous recombination-mediated DNA DSB repair, thereby enhancing radioresistance in esophageal squamous cell carcinoma. Co-immunoprecipitation, ubiquitination assay (K48-linked, site-specific K425), in vitro and in vivo irradiation models, HR repair assay, rescue by PARP1 overexpression Cancer letters Medium 37838281
2024 DCAF7 serves as a scaffold protein that facilitates the interaction between USP10 and G3BP1, leading to elimination of K48-linked ubiquitin moieties from Lys76 of G3BP1, preventing its degradation and promoting stress granule-like structure formation and cisplatin resistance. Co-immunoprecipitation, ubiquitination assay (K48-linked, site K76), siRNA knockdown, SG formation assay, in vitro and in vivo cisplatin resistance assay Advanced science Medium 38973296
2024 USP10 binds to and deubiquitinates MOF (KAT8) at lysine 410, protecting it from proteasomal degradation; MOF stabilization by USP10 promotes H4K16 acetylation at the ANXA2 promoter, stimulating ANXA2 transcription and activating Wnt/β-catenin signaling. Co-immunoprecipitation, ubiquitination assay (site K410), H4K16ac ChIP, ANXA2 promoter reporter, siRNA knockdown, in vitro and in vivo tumor models Oncogene Medium 38317006
2020 USP10 interacts with and stabilizes CD36 by removing polyubiquitin; USP10 deletion reduces CD36 protein (not mRNA) and suppresses macrophage lipid uptake and foam cell formation. Co-immunoprecipitation, ubiquitination assay, RT-qPCR, western blot, Oil-Red-O staining, flow cytometry lipid uptake assay Aging Medium 33197885
2023 USP10 interacts with INKILN lncRNA and MKL1; INKILN knockdown enhances MKL1 ubiquitination through reduced interaction with USP10, destabilizing MKL1; INKILN thus stabilizes MKL1 and promotes NF-κB-dependent VSMC inflammation. RNA pull-down, co-immunoprecipitation, ubiquitination assay, siRNA knockdown, NF-κB reporter, BAC transgenic mice, neointimal formation model Circulation Medium 37199168

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 689 21962518
2010 USP10 regulates p53 localization and stability by deubiquitinating p53. Cell 510 20096447
2016 G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. The Journal of cell biology 507 27022092
2013 USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation. Cell reports 164 24332849
2020 USP10 Promotes Proliferation of Hepatocellular Carcinoma by Deubiquitinating and Stabilizing YAP/TAZ. Cancer research 158 32217697
2001 Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. Oncogene 158 11439350
2016 Deubiquitination and Activation of AMPK by USP10. Molecular cell 130 26876938
2017 Inhibition of USP10 induces degradation of oncogenic FLT3. Nature chemical biology 120 28967922
2019 The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis. Cell death and differentiation 116 31748695
2020 The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation. Molecular cell 109 31981475
2011 USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation. Nucleic acids research 104 21245042
2009 The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells. The Journal of biological chemistry 100 19398555
2018 Ubiquitin-Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6. Hepatology (Baltimore, Md.) 98 29698567
2013 USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO. The EMBO journal 96 24270572
2022 Hypoxia-induced circWSB1 promotes breast cancer progression through destabilizing p53 by interacting with USP10. Molecular cancer 95 35351136
2015 TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. The Journal of biological chemistry 91 25861989
2021 NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer. Journal of experimental & clinical cancer research : CR 87 33838681
2019 Deubiquitinase USP10 regulates Notch signaling in the endothelium. Science (New York, N.Y.) 83 30975888
2018 Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer. Molecular cancer research : MCR 79 29378906
2013 HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10. Blood 78 23775713
2020 When the chains do not break: the role of USP10 in physiology and pathology. Cell death & disease 77 33277473
2019 USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia. Cell discovery 73 31044085
2018 Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF. Cell death and differentiation 73 29472714
2019 Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein. Molecular oncology 72 31721429
2017 USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN. Molecular and cellular biochemistry 69 28852924
2023 Stabilization of IGF2BP1 by USP10 promotes breast cancer metastasis via CPT1A in an m6A-dependent manner. International journal of biological sciences 66 36632454
2005 The ubiquitin-specific protease USP10 modulates androgen receptor function. Molecular and cellular endocrinology 63 16368182
2021 The deubiquitinase USP10 restores PTEN activity and inhibits non-small cell lung cancer cell proliferation. The Journal of biological chemistry 62 34416231
2018 USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma. Cancer letters 61 30056112
2022 HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway. Journal of experimental & clinical cancer research : CR 55 35277183
2020 Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis. Acta pharmacologica Sinica 55 33184448
2023 INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10. Circulation 54 37199168
2022 Structure and hepatoprotective activity of Usp10/NF-κB/Nrf2 pathway-related Morchella esculenta polysaccharide. Carbohydrate polymers 54 36657860
2020 The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53. Cell death & disease 53 32382008
2024 Modulation of YBX1-mediated PANoptosis inhibition by PPM1B and USP10 confers chemoresistance to oxaliplatin in gastric cancer. Cancer letters 47 38364962
2022 USP10 as a Potential Therapeutic Target in Human Cancers. Genes 47 35627217
2018 USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway. American journal of physiology. Cell physiology 47 30281322
2016 RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation. Nature communications 47 27558965
2017 Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10. Journal of molecular biology 46 28587923
2022 Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma. Cell death and differentiation 45 36526897
2016 Ubiquitin-specific Peptidase 10 (USP10) Deubiquitinates and Stabilizes MutS Homolog 2 (MSH2) to Regulate Cellular Sensitivity to DNA Damage. The Journal of biological chemistry 44 26975374
2014 MicroRNA-191 promotes pancreatic cancer progression by targeting USP10. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 44 25168367
2019 TRAF4 Promotes Fibroblast Proliferation in Keloids by Destabilizing p53 via Interacting with the Deubiquitinase USP10. The Journal of investigative dermatology 43 30940456
2018 USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis. iScience 43 30469013
2020 Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin. Journal of cellular and molecular medicine 41 32129945
2019 Long noncoding RNA Mirt2 upregulates USP10 expression to suppress hepatic steatosis by sponging miR-34a-5p. Gene 41 30898698
2019 USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells. Scientific reports 41 31332267
2021 USP10 alleviates sepsis-induced acute kidney injury by regulating Sirt6-mediated Nrf2/ARE signaling pathway. Journal of inflammation (London, England) 40 34412625
2020 Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta pharmacologica Sinica 39 32694757
2014 Deubiquitination and stabilization of T-bet by USP10. Biochemical and biophysical research communications 39 24845384
2022 Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability. Military Medical Research 37 36163081
2018 USP10 regulates the stability of the EMT-transcription factor Slug/SNAI2. Biochemical and biophysical research communications 36 29803676
2010 The deubiquitinating enzyme USP10 regulates the endocytic recycling of CFTR in airway epithelial cells. Channels (Austin, Tex.) 36 20215869
2023 A microprotein N1DARP encoded by LINC00261 promotes Notch1 intracellular domain (N1ICD) degradation via disrupting USP10-N1ICD interaction to inhibit chemoresistance in Notch1-hyperactivated pancreatic cancer. Cell discovery 34 37714834
2019 USP10 regulates Musashi-2 stability via deubiquitination and promotes tumour proliferation in colon cancer. FEBS letters 34 30604502
2023 USP10 deubiquitinates RUNX1 and promotes proneural-to-mesenchymal transition in glioblastoma. Cell death & disease 33 36949071
2021 FSTL1-USP10-Notch1 Signaling Axis Protects Against Cardiac Dysfunction Through Inhibition of Myocardial Fibrosis in Diabetic Mice. Frontiers in cell and developmental biology 32 34957094
2023 LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization. Journal of experimental & clinical cancer research : CR 31 37072811
2020 Inhibition of the deubiquitinase USP10 induces degradation of SYK. British journal of cancer 28 32015510
2019 USP10 protects against cerebral ischemia injury by suppressing inflammation and apoptosis through the inhibition of TAK1 signaling. Biochemical and biophysical research communications 28 31301769
2019 G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10. Scientific reports 28 31501480
2021 The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity. The Journal of biological chemistry 27 33577797
2023 The AEG-1-USP10-PARP1 axis confers radioresistance in esophageal squamous cell carcinoma via facilitating homologous recombination-dependent DNA damage repair. Cancer letters 26 37838281
2021 Circ-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84. Bioengineered 26 34753388
2023 Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma. Cancer letters 25 37757903
2017 The deubiquitylase USP10 regulates integrin β1 and β5 and fibrotic wound healing. Journal of cell science 25 28851806
2010 USP10: friend and foe. Cell 25 20144755
2023 KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer. Cell death & disease 24 36807568
2023 USP10 Regulates ZEB1 Ubiquitination and Protein Stability to Inhibit ZEB1-Mediated Colorectal Cancer Metastasis. Molecular cancer research : MCR 24 36940483
2022 Limonin stabilises sirtuin 6 (SIRT6) by activating ubiquitin specific peptidase 10 (USP10) in cardiac hypertrophy. British journal of pharmacology 24 35727596
2021 Estrogen prevents cellular senescence and bone loss through Usp10-dependent p53 degradation in osteocytes and osteoblasts: the role of estrogen in bone cell senescence. Cell and tissue research 24 34223980
2022 USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID. Signal transduction and targeted therapy 22 34983926
2024 Stabilization of MOF (KAT8) by USP10 promotes esophageal squamous cell carcinoma proliferation and metastasis through epigenetic activation of ANXA2/Wnt signaling. Oncogene 21 38317006
2023 USP10 is a potential mediator for vagus nerve stimulation to alleviate neuroinflammation in ischaemic stroke by inhibiting NF-κB signalling pathway. Frontiers in immunology 20 37153558
2021 LncRNA GASAL1 promotes hepatocellular carcinoma progression by up-regulating USP10-stabilized PCNA. Experimental cell research 20 34914965
2021 FoxO4 negatively modulates USP10 transcription to aggravate the apoptosis and oxidative stress of hypoxia/reoxygenation-induced cardiomyocytes by regulating the Hippo/YAP pathway. Journal of bioenergetics and biomembranes 19 34251583
2021 USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity. The Journal of biological chemistry 19 34838592
2020 USP10 deletion inhibits macrophage-derived foam cell formation and cellular-oxidized low density lipoprotein uptake by promoting the degradation of CD36. Aging 19 33197885
2024 DCAF7 Acts as A Scaffold to Recruit USP10 for G3BP1 Deubiquitylation and Facilitates Chemoresistance and Metastasis in Nasopharyngeal Carcinoma. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 18 38973296
2023 USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential. Cell chemical biology 18 37611590
2022 USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance. Molecular and cellular biology 18 35007165
2025 USP10/XAB2/ANXA2 axis promotes DNA damage repair to enhance chemoresistance to oxaliplatin in colorectal cancer. Journal of experimental & clinical cancer research : CR 17 40069750
2023 USP10 Contributes to Colon Carcinogenesis via mTOR/S6K Mediated HIF-1α but Not HIF-2α Protein Synthesis. Cells 17 37371055
2023 Downregulated circPOKE promotes breast cancer metastasis through activation of the USP10-Snail axis. Oncogene 17 37717099
2022 CircCOL1A2 Sponges MiR-1286 to Promote Cell Invasion and Migration of Gastric Cancer by Elevating Expression of USP10 to Downregulate RFC2 Ubiquitination Level. Journal of microbiology and biotechnology 17 35791074
2019 RNAi Screening-based Identification of USP10 as a Novel Regulator of Paraptosis. Scientific reports 17 30894572
2024 The USP10/13 inhibitor, spautin-1, attenuates the progression of glioblastoma by independently regulating RAF-ERK mediated glycolysis and SKP2. Biochimica et biophysica acta. Molecular basis of disease 16 38857836
2024 FOXP4-AS1 promotes CD8+ T cell exhaustion and esophageal cancer immune escape through USP10-stabilized PD-L1. Immunologic research 15 38687433
2024 NDR1 mediates PD-L1 deubiquitination to promote prostate cancer immune escape via USP10. Cell communication and signaling : CCS 15 39227807
2021 USP10 exacerbates neointima formation by stabilizing Skp2 protein in vascular smooth muscle cells. The Journal of biological chemistry 15 34599966
2024 Tuning Immune-Cold Tumor by Suppressing USP10/B7-H4 Proteolytic Axis Reinvigorates Therapeutic Efficacy of ADCs. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 14 39206932
2024 Recruitment of USP10 by GCS1 to deubiquitinate GRP78 promotes the progression of colorectal cancer via alleviating endoplasmic reticulum stress. Journal of experimental & clinical cancer research : CR 14 39267084
2023 USP10 regulates macrophage inflammation responses via stabilizing NEMO in LPS-induced sepsis. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 14 37436447
2024 Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop. Experimental & molecular medicine 13 38689092
2024 Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis. Cell & bioscience 13 39218913
2022 USP10 Alleviates Palmitic Acid-induced Steatosis through Autophagy in HepG2 Cells. Journal of clinical and translational hepatology 13 36406315
2020 USP10 Targeted Self-Deliverable siRNA to Prevent Scarring in the Cornea. Molecular therapy. Nucleic acids 13 32829179
2023 Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10. International journal of medical sciences 12 37786443
2023 The deubiquitinase USP10 mediates crosstalk between the LKB1/AMPK axis and Wnt/β-catenin signaling in cancer. FEBS letters 12 37873736
2022 Loss of Ras GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) inhibits the progression of ovarian cancer in coordination with ubiquitin-specific protease 10 (USP10). Bioengineered 12 34967276