Affinage

USP10

Ubiquitin carboxyl-terminal hydrolase 32 · UniProt Q8NFA0

Length
1604 aa
Mass
181.7 kDa
Annotated
2026-06-10
100 papers in source corpus 61 papers cited in narrative 60 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

USP10 is a cytoplasmic and nuclear ubiquitin-specific deubiquitinase that controls the abundance and activity of a broad repertoire of substrates by removing ubiquitin chains and protecting them from proteasomal or lysosomal degradation (PMID:20096447, PMID:26876938). Its prototypical role is stabilization of the tumor suppressor p53: USP10 deubiquitinates p53, reversing Mdm2-induced nuclear export and degradation, and following DNA damage it is stabilized and translocates to the nucleus through ATM-dependent phosphorylation at Thr42/Ser337 to activate p53 (PMID:20096447). Substrate engagement and nuclear access are governed by phosphorylation: AMPK phosphorylation at Ser76 forms a feedforward loop that enhances USP10-mediated deubiquitination of AMPKα to license LKB1 phosphorylation (PMID:26876938), while AKT phosphorylation at T674 within the NLS drives nuclear translocation to stabilize AID (PMID:34983926). Beyond p53, USP10 stabilizes a wide range of regulators across opposing oncogenic and tumor-suppressive programs, including SIRT6 (PMID:24332849, PMID:29698567), YAP/TAZ (PMID:32217697), FLT3 (PMID:28967922), KLF4 (PMID:31748695), Smad4 (PMID:31721429), PTEN (PMID:28852924, PMID:34416231), MSH2 (PMID:26975374), NICD1 (PMID:30975888), and the histone variant H2A.Z (PMID:21245042), frequently via removal of specific K48-, K63-, K11-, or K27/K29-linked chains (PMID:34416231, PMID:36526897, PMID:37757903, PMID:37838281). USP10 is a core component of stress granule biology: its mutually exclusive binding to G3BP1 (versus Caprin1) inhibits stress granule condensation (PMID:27022092), and G3BP1–USP10 complexes deubiquitinate monoubiquitinated 40S ribosomal proteins (RPS2/3/10) to rescue stalled subunits from lysosomal degradation during ribosome-associated quality control (PMID:31981475). In NF-κB signaling, USP10 acts through scaffolds MCPIP1 and TANK to deubiquitinate NEMO and TRAF6, restraining genotoxic and innate-immune NF-κB activation (PMID:24270572, PMID:25861989). USP10 also supports autophagy by deubiquitinating LC3B (PMID:33577797), regulates angiogenesis through endothelial Notch signaling (PMID:30975888), and contributes to DNA damage repair, cytokinesis, and immune responses (PMID:36526897, PMID:34983926, PMID:37838281). Many substrate interactions are directed by recruiting scaffolds (DCAF7, KIF15, AEG-1, NDR1), and its catalytic Cys424 is a validated druggable interface targeted by ubiquitin variants and small-molecule inhibitors (PMID:28587923, PMID:32694757).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2010 High

    Established USP10 as a bona fide deubiquitinase with a defined physiological substrate by showing it reverses Mdm2-driven p53 degradation and links DNA-damage signaling to p53 activation.

    Evidence Co-IP, in vitro deubiquitination, subcellular fractionation, ATM kinase assay and mutagenesis of Thr42/Ser337 in a p53-dependent system

    PMID:20096447

    Open questions at the time
    • Did not define the full set of ubiquitin chain linkages on p53 removed by USP10
    • Structural basis of substrate recognition not resolved
  2. 2011 High

    Connected USP10 activity to autophagy/tumor-suppressor circuitry by showing Beclin1 controls USP10 stability and USP10 reciprocally deubiquitinates Beclin1, defining a regulated DUB-substrate feedback node.

    Evidence Spautin-1 small-molecule perturbation, Co-IP, ubiquitination and protein stability assays

    PMID:21962518

    Open questions at the time
    • Mechanism by which Beclin1 controls USP10 catalytic activity not fully defined
  3. 2009 High

    Showed USP10 acts at endosomal membranes to control receptor trafficking, deubiquitinating CFTR to promote recycling rather than lysosomal degradation, expanding its role beyond proteasomal substrate stabilization.

    Evidence Activity-based DUB screen, dominant-negative C424A, endosomal fractionation, chloride secretion assay

    PMID:19398555

    Open questions at the time
    • Recruitment to endosomes not mapped
    • Generality of trafficking role for other receptors unclear at the time
  4. 2016 High

    Defined phospho-regulation of USP10 catalytic output, showing AMPK phosphorylation at Ser76 amplifies USP10-mediated AMPKα deubiquitination in a feedforward loop linking it to energy-stress signaling.

    Evidence In vitro deubiquitination and kinase assays, Ser76 mutagenesis, metabolic loss-of-function readout

    PMID:26876938

    Open questions at the time
    • Whether multiple kinases converge on overlapping sites not resolved
  5. 2016 High

    Established USP10's central role in stress granule biology, showing G3BP1 binding to USP10 is mutually exclusive with Caprin1 and inhibits stress granule formation.

    Evidence G3BP1/G3BP2 double-knockout cells with G3BP1 point-mutant rescues and Co-IP

    PMID:27022092

    Open questions at the time
    • Whether USP10 catalytic activity is required for SG inhibition not fully separated from binding
  6. 2020 High

    Extended the G3BP1-USP10 axis to ribosome-associated quality control, showing the complex deubiquitinates 40S ribosomal proteins to rescue stalled subunits from lysosomal degradation.

    Evidence CRISPR knockouts, ubiquitination assay, RPS3-K214R rescue, ribosome stoichiometry and MS

    PMID:31981475

    Open questions at the time
    • How the complex discriminates aberrant from normal 40S subunits not defined
  7. 2015 Medium

    Defined a scaffold-directed mechanism for USP10 in NF-κB control, showing MCPIP1- and TANK-dependent deubiquitination of NEMO and TRAF6 restrains genotoxic and innate-immune NF-κB activation.

    Evidence Reciprocal Co-IP, ubiquitination assays, CRISPR/Cas9 deletion, NF-κB reporter and cytokine ELISA

    PMID:24270572 PMID:25861989

    Open questions at the time
    • Context-dependent switch between NF-κB-suppressing and NF-κB-stabilizing roles (cf. NEMO stabilization in sepsis) not reconciled
    • Direct chain-linkage specificity on TRAF6 not fully mapped
  8. 2019 High

    Demonstrated an in vivo developmental function, showing endothelial USP10 stabilizes NICD1 to tune Notch-dependent vessel sprouting and patterning.

    Evidence Endothelial-specific Usp10 knockout mouse, in vivo sprouting angiogenesis, genetic epistasis with NICD1

    PMID:30975888

    Open questions at the time
    • Chain-linkage specificity on NICD1 in endothelium not defined
  9. 2021 High

    Identified USP10 as a regulator of the autophagy machinery itself, showing it deubiquitinates LC3B to prevent its proteasomal turnover and sustain receptor-mediated clearance.

    Evidence CRISPR-Cas9 KO, ubiquitination assay, proteasome inhibition, autophagy receptor degradation assays

    PMID:33577797

    Open questions at the time
    • Whether LC3B deubiquitination is the dominant mechanism by which USP10 affects autophagic flux in vivo not established
  10. 2023 High

    Revealed an enzyme-independent function, showing USP10 physically tethers Axin1 and β-catenin and promotes phase separation to suppress Wnt signaling, in addition to K48-linked deubiquitination of Axin1.

    Evidence Unbiased DUB screen, in vitro binding, computational modeling, phase-separation assay, enzymatic mutant, CRC organoid and xenograft

    PMID:37611590 PMID:39443725

    Open questions at the time
    • Structural determinants distinguishing scaffolding from catalytic functions not resolved
  11. 2023 Medium

    Showed substrate specificity of USP10 is frequently dictated by recruiting scaffolds, with DCAF7, KIF15, and AEG-1 bridging USP10 to G3BP1, PGK1, and PARP1 respectively, and ERK phosphorylation gating substrate access.

    Evidence Co-IP/MS, domain-mapping, site-specific ubiquitination assays, phospho-site mapping, functional cancer models

    PMID:36807568 PMID:36940483 PMID:37838281 PMID:38973296

    Open questions at the time
    • A unifying model of how scaffolds and phospho-marks combinatorially select among the many USP10 substrates is lacking
    • Most scaffold mechanisms rest on single-lab evidence

Open questions

Synthesis pass · forward-looking unresolved questions
  • How USP10 selects among its very large and functionally opposing substrate set in a given cellular context, and what structural features define its catalytic versus scaffolding modes, remain unresolved.
  • No structural model of USP10 substrate engagement
  • No systematic map of which phospho-states and scaffolds direct which substrates
  • Reconciliation of tumor-suppressive vs oncogenic outputs in vivo incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 6 GO:0016787 hydrolase activity 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 2 GO:0005768 endosome 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-392499 Metabolism of proteins 4 R-HSA-8953854 Metabolism of RNA 3 R-HSA-9612973 Autophagy 3 R-HSA-73894 DNA Repair 2
Partners
AMPKΑG3BP1MCPIP1NEMONICD1PTENSIRT6TP53
Complex memberships
G3BP1-USP10 stress granule complexMCPIP1-TANK-USP10 NF-κB regulatory complex

Evidence

Reading pass · 60 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 USP10 is a cytoplasmic deubiquitinase that deubiquitinates p53, reversing Mdm2-induced p53 nuclear export and degradation. After DNA damage, USP10 is stabilized and translocates to the nucleus to activate p53; this translocation and stabilization is regulated by ATM-mediated phosphorylation of USP10 at Thr42 and Ser337. Co-immunoprecipitation, in vitro deubiquitination assay, subcellular fractionation, ATM kinase assay, site-directed mutagenesis, loss-of-function experiments with defined p53-dependent phenotypic readout Cell High 20096447
2011 Beclin1 controls the protein stability of USP10 (and USP13) by regulating their deubiquitinating activities. USP10 mediates deubiquitination of p53, and Beclin1-regulated USP10 activity provides a mechanism linking the tumor suppressors Beclin1 and p53. USP10 and USP13 also deubiquitinate the Beclin1 subunit of Vps34 PI3 kinase complexes, protecting them from degradation. Small molecule inhibitor (spautin-1) studies, co-immunoprecipitation, ubiquitination assays, loss-of-function experiments, in-cell protein stability assays Cell High 21962518
2011 USP10 directly deubiquitylates the histone variant H2A.Z in vitro and in vivo. USP10 and H2A.Z are both required for transcriptional activation of androgen receptor (AR)-regulated genes (PSA and KLK3); knockdown of USP10 elevates steady-state mono-ubiquitylated H2A.Z and ablates hormone-induced deubiquitylation at AR-regulated gene regulatory regions. In vitro deubiquitylation assay, ChIP, sequential ChIP, siRNA knockdown, reporter assays Nucleic acids research High 21245042
2009 USP10 is localized in early endosomes in airway epithelial cells and deubiquitinates endocytosed CFTR, promoting its recycling back to the apical membrane rather than lysosomal degradation. siRNA knockdown of USP10 increased ubiquitinated CFTR and lysosomal degradation; dominant-negative USP10-C424A increased ubiquitinated CFTR degradation; overexpression of wt-USP10 decreased ubiquitinated CFTR. Activity-based chemical DUB screen, siRNA knockdown, dominant-negative overexpression (C424A mutant), endosomal fractionation, chloride secretion assay, co-immunoprecipitation The Journal of biological chemistry High 19398555
2016 USP10 specifically removes ubiquitin from AMPKα to facilitate AMPKα phosphorylation by LKB1. Ubiquitination on AMPKα blocks LKB1-mediated phosphorylation. Under energy stress, AMPK-mediated phosphorylation of USP10 at Ser76 enhances USP10 activity, forming a feedforward loop amplifying AMPK activation. In vitro deubiquitination assay, in vitro kinase assay, co-immunoprecipitation, site-directed mutagenesis (Ser76), genetic loss-of-function with metabolic phenotypic readout Molecular cell High 26876938
2013 USP10 interacts with SIRT6 and suppresses SIRT6 ubiquitination, protecting SIRT6 from proteasomal degradation. Through stabilizing SIRT6, USP10 antagonizes c-Myc transcriptional activity and inhibits cell-cycle progression. Proteomic approach (co-IP/MS), co-immunoprecipitation, ubiquitination assay, cell-cycle analysis, loss-of-function experiments Cell reports Medium 24332849
2013 USP10 interacts with NEMO via the scaffold protein MCPIP1 upon genotoxic stress and removes linear polyubiquitin chains from NEMO, resulting in decreased IKK and NF-κB activation. USP10 is required for MCPIP1-mediated inhibition of genotoxic NF-κB activation. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, NF-κB reporter assay, epistasis experiments The EMBO journal Medium 24270572
2015 USP10 forms a complex with TANK and MCPIP1 that mediates deubiquitination of TRAF6, suppressing NF-κB activation induced by genotoxic stress and IL-1R/TLR stimulation. CRISPR/Cas9 deletion of TANK enhanced NF-κB activation and inflammatory cytokine production. Co-immunoprecipitation, ubiquitination assay, CRISPR/Cas9 deletion, NF-κB reporter assay, cytokine ELISA The Journal of biological chemistry Medium 25861989
2016 G3BP1/G3BP2 and USP10 form complexes that mediate stress granule (SG) condensation. G3BP1 phosphomimetic S149E mutant fails to rescue SG formation, while G3BP1-F33W mutant (unable to bind Caprin1 or USP10) rescues SG formation. Caprin1 binding promotes SG formation while USP10 binding to G3BP inhibits SG formation; these two interactions are mutually exclusive. Genetic rescue experiments with G3BP1 point mutants, G3BP1/G3BP2 double-knockout cells, stress granule induction assays, co-immunoprecipitation The Journal of cell biology High 27022092
2016 USP10 as part of G3BP1-family complexes deubiquitinates monoubiquitinated RPS2, RPS3, and RPS10 on 40S ribosomal subunits stalled at aberrant mRNAs. This rescues modified 40S subunits from lysosomal degradation during ribosome-associated quality control. Knockout of USP10 or G3BP1-family proteins increased lysosomal ribosomal degradation and perturbed ribosomal subunit stoichiometry; K214R substitution in RPS3 rescued these phenotypes. CRISPR knockout, ubiquitination assay, ribosomal subunit stoichiometry analysis, rescue with RPS3-K214R mutant, mass spectrometry Molecular cell High 31981475
2017 USP10 is required to stabilize oncogenic FLT3 (FLT3-ITD and FLT3-D835Y) by preventing its ubiquitin-mediated proteasomal degradation. Pharmacological or genetic inhibition of USP10 induces FLT3 degradation and shows efficacy in preclinical AML models. DUB inhibitor library screen, target deconvolution, co-immunoprecipitation, ubiquitination assay, cell-line and primary patient cell models, mouse xenograft model Nature chemical biology High 28967922
2016 RNF168 E3 ligase mediates ubiquitylation of TOP2α, while USP10 acts as the deubiquitylase that negatively regulates TOP2α ubiquitylation and restrains its chromatin association. The opposing actions of RNF168 and USP10 on TOP2α ubiquitylation modulate decatenation activity. Co-immunoprecipitation, ubiquitination assay, ChIP, genetic loss-of-function with chromosomal segregation phenotypic readout Nature communications Medium 27558965
2019 USP10 interacts with NOTCH1 intracellular domain (NICD1) to slow the ubiquitin-dependent turnover of NICD1. Inactivation of USP10 reduced NICD1 abundance and stability and diminished Notch-induced target gene expression in endothelial cells. Loss of endothelial Usp10 increased vessel sprouting in mice and partially restored patterning defects caused by ectopic NICD1 expression. Co-immunoprecipitation, protein stability assay, endothelial-specific Usp10 knockout mouse, in vivo sprouting angiogenesis assay, gene expression analysis Science High 30975888
2019 USP10 deubiquitinates and stabilizes KLF4 by blocking its proteasomal degradation. Loss of USP10 in mice downregulates KLF4 and accelerates KrasG12D-driven lung adenocarcinoma. KLF4 in turn facilitates transcription of TIMP3 by binding its promoter. siRNA screen of ubiquitin-specific proteases, co-immunoprecipitation, ubiquitination assay, conditional USP10 knockout mouse with KrasG12D, promoter binding by ChIP Cell death and differentiation High 31748695
2019 USP10 deubiquitinates and stabilizes Smad4, sustaining TGF-β signaling. USP10 directly interacts with Smad4 and cleaves its proteolytic ubiquitin chains, promoting HCC metastasis. Suppression of USP10 inhibits HCC cell migration; reconstitution of Smad4 rescues this defect. siRNA library screen of USPs, co-immunoprecipitation, ubiquitination assay, migration assay, rescue experiment with Smad4 Molecular oncology Medium 31721429
2020 USP10 directly interacts with YAP and TAZ, deubiquitinates them by reverting their proteolytic ubiquitination, and stabilizes them. Depletion of USP10 enhanced polyubiquitination of YAP/TAZ and promoted their proteasomal degradation, arresting hepatocellular carcinoma proliferation in vitro and in vivo. DUB screen (transcriptional activity and protein abundance), co-immunoprecipitation, ubiquitination assay, siRNA knockdown, in vivo xenograft Cancer research High 32217697
2018 USP10 interacts with and deubiquitinates G3BP2, maintaining G3BP2 protein stability and reducing its polyubiquitylation. G3BP2-dependent growth activation and p53 nuclear export are repressed by USP10 knockdown, placing USP10 upstream of the G3BP2-p53 axis. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, chromatin immunoprecipitation, cell growth assay Molecular cancer research Medium 29378906
2013 HTLV-1 Tax oncoprotein interacts with USP10 and inhibits arsenic-induced stress granule formation by USP10-containing SGs, stimulating ROS production and augmenting ROS-dependent apoptosis. USP10 normally functions to inhibit stress-induced ROS production and apoptosis; Tax attenuates this activity. Co-immunoprecipitation, stress granule formation assay, ROS measurement, apoptosis assay Blood Medium 23775713
2019 USP10 is a novel deubiquitinase of SKP2; it binds to and deubiquitinates SKP2, preventing its degradation. Stabilized SKP2 in turn mediates K63-linked ubiquitination and activation of Bcr-Abl, creating a USP10/SKP2/Bcr-Abl axis in CML. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, cell proliferation assay in imatinib-sensitive and -resistant CML cells Cell discovery Medium 31044085
2016 USP10 interacts with MSH2 and deubiquitinates it both in vitro and in vivo, stabilizing MSH2 protein. Knockdown of USP10 in lung cancer cells exhibits increased cell survival and decreased apoptosis upon treatment with MNNG and 6-TG; these phenotypes are rescued by ectopic MSH2 expression. MSH2 protein level correlates positively with USP10 level. Co-immunoprecipitation, in vitro deubiquitination assay, siRNA knockdown, mismatch repair activity assay, cell survival/apoptosis assay, rescue experiment The Journal of biological chemistry High 26975374
2018 USP10 mediates deubiquitination of p14ARF, preventing its proteasome-dependent degradation. c-Myc induces USP10 transcription; USP10 then stabilizes p14ARF to enforce oncogene-induced senescence. USP10-null MEFs and primary cells depleted of USP10 bypass c-Myc-induced senescence via p14ARF destabilization. Ubiquitination assay, siRNA knockdown, USP10-null MEFs, cell senescence assay (SA-β-gal, proliferation), c-Myc overexpression epistasis Cell death and differentiation Medium 29472714
2017 USP10 interacts with integrin β1 and β5; recombinant USP10 removes ubiquitin from these integrin subunits in vitro. Loss of USP10 induces ubiquitin accumulation on β1/β5 integrins, decreasing αv/β1/β5 protein levels and TGFβ activation. Gain of USP10 increases αv/β1/β5 protein levels and fibrotic marker expression. Genetic screen, siRNA knockdown, recombinant USP10 in vitro deubiquitination, co-immunoprecipitation, ex vivo cornea organ culture, loss- and gain-of-function with fibrotic marker readout Journal of cell science Medium 28851806
2005 USP10 is part of DNA-bound androgen receptor (AR) complexes in nuclear extracts. Interaction with AR confirmed by GST pull-down. USP10 localizes in both nucleus and cytoplasm. Overexpression of catalytically active, but not enzymatically inactive, USP10 stimulates AR transactivation at AREs, SREs, and MMTV promoter; siRNA knockdown of USP10 impairs MMTV androgen response. Nuclear extract purification, GST pull-down, fluorescence microscopy, cell-based transactivation reporter assay, siRNA knockdown Molecular and cellular endocrinology Medium 16368182
2017 Crystal structure of UbV.7.2 (ubiquitin variant inhibitor) was solved and provided the molecular basis for enhanced affinity and specificity for USP7. UbVs were also identified that bound USP10 with high affinity and inhibited its deubiquitination activity, validating the catalytic site of USP10 as a druggable interface. Phage-displayed UbV library, crystal structure determination (for USP7 UbV), in vitro deubiquitination inhibition assay, cell death assay Journal of molecular biology Medium 28587923
2018 USP10 interacts with HDAC6 and deubiquitinates and stabilizes HDAC6. Reintroduction of either USP10 or HDAC6 into USP10-knockdown NSCLC cells with null p53 restores cisplatin resistance, defining a USP10-HDAC6-cisplatin resistance axis. Co-immunoprecipitation, ubiquitination assay, siRNA/genetic knockdown, rescue experiment with USP10 or HDAC6, xenograft model Cell death & disease Medium 32382008
2014 USP10 interacts with T-bet transcription factor in the nucleus, directly inhibits T-bet ubiquitination, and increases T-bet protein expression. Quercetin, a reported T-bet inhibitor, targets USP10 to promote T-bet proteasomal degradation. Co-immunoprecipitation, ubiquitination assay, overexpression, inhibitor treatment (quercetin) Biochemical and biophysical research communications Low 24845384
2021 USP10 deubiquitinates LC3B, reversing monoubiquitination-mediated proteasomal degradation of LC3B. CRISPR-Cas9 KO of USP10 reduces both LC3B-I and LC3B-II levels through increased ubiquitination and proteasomal degradation, leading to slower degradation of autophagy receptors SQSTM1 and NBR1 and increased aggresome-like structures. CRISPR-Cas9 knockout screen, biochemical ubiquitination assay, proteasome inhibitor experiments, autophagy receptor degradation assay The Journal of biological chemistry High 33577797
2018 USP10 interacts with p62 (ubiquitin receptor) and the USP10-p62 interaction augments p62-dependent ubiquitinated protein aggregation and aggresome formation, thereby inhibiting apoptosis. USP10-p62-induced protein aggregates inhibit proteasome activity, further increasing ubiquitinated protein levels. USP10 co-localizes with α-synuclein in Lewy bodies in Parkinson disease brains. Co-immunoprecipitation, aggresome formation assay, proteasome activity assay, immunohistochemistry of PD brain tissue iScience Medium 30469013
2019 USP10 is a critical factor for the formation of Tau/TIA1/USP10-positive stress granules in neuronal cells. Depletion of USP10 severely attenuates TIA1/Tau-positive SG formation induced by proteasome inhibition or TIA1 overexpression. Overexpression of USP10 without stress stimuli induces TIA1/Tau/USP10-positive SGs in a deubiquitinase-independent manner. siRNA knockdown, overexpression with catalytically inactive control, immunofluorescence of SG formation, immunohistochemistry of AD brain tissue Scientific reports Medium 31332267
2021 USP10 promotes clearance of TDP-43-positive stress granules and thereby inhibits aberrant cytoplasmic aggregation of TDP-43/TDP-35 in neuronal cells. Depletion of USP10 increases insoluble TDP-35 in the cytoplasm. TDP-35 interacts with USP10 in an RNA-binding-dependent manner. siRNA knockdown, overexpression, stress granule clearance assay, solubility fractionation, co-immunoprecipitation, immunohistochemistry of ALS patient tissue Molecular and cellular biology Medium 35007165
2019 USP10 interacts with Raf-1 and promotes its deubiquitination, stabilizing Raf-1 protein (without affecting mRNA), which activates downstream MEK/ERK signaling. USP10 overexpression promotes proliferation, migration, and inhibits apoptosis of endometrial stromal cells via Raf-1/MEK/ERK; effects are blocked by MEK inhibitor PD-98059. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, overexpression, MEK inhibitor rescue, proliferation/apoptosis/migration assays American journal of physiology. Cell physiology Medium 30281322
2018 USP10 interacts with SIRT6 and inhibits its ubiquitination and degradation in the liver. USP10 deficiency exacerbates HFD-induced metabolic dysfunction; SIRT6 overexpression reverses USP10 deficiency effects; SIRT6 deficiency counteracts USP10 overexpression benefits, placing USP10 upstream of SIRT6 in hepatic metabolism. Co-immunoprecipitation, ubiquitination assay, hepatocyte-specific USP10 knockout and overexpression mouse models, genetic epistasis with SIRT6 Hepatology High 29698567
2019 USP10 deubiquitinates and stabilizes Musashi-2 (MSI2) through direct interaction, preventing its proteasomal degradation, and thereby promotes colon cancer cell proliferation. Co-immunoprecipitation, ubiquitination assay, protein stability assay, cell proliferation assay FEBS letters Low 30604502
2017 USP10 is the major DUB required for stabilization of SYK. USP10 inhibition leads to proteasome-mediated SYK degradation and potentiates anti-leukemic effects of FLT3 inhibition. Co-immunoprecipitation, ubiquitination assay, USP10 inhibitor treatment, cell viability assay British journal of cancer Medium 32015510
2016 USP10 directly interacts with and stabilizes PTEN through deubiquitination in lung cancer cells. Co-immunoprecipitation confirmed the interaction; ubiquitination/deubiquitination assays confirmed the mechanism. Pro-cancerous effects of USP10 deficiency are abolished by PTEN re-introduction. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, PTEN rescue experiment, in vivo allograft Molecular and cellular biochemistry Medium 28852924
2021 USP10 interacts with PTEN and removes TRIM25-mediated K63-linked polyubiquitination of PTEN, restoring PTEN phosphatase activity and reducing PIP3 production, thereby inhibiting AKT/mTOR signaling. The inactive C424A mutant of USP10 fails to reverse PTEN ubiquitination. Co-immunoprecipitation, ubiquitination assay with K63-specific chains, C424A inactive mutant, PIP3 measurement, AKT/mTOR signaling assay, NSCLC proliferation assay The Journal of biological chemistry High 34416231
2022 USP10 deubiquitinates and stabilizes ANLN (anillin) by removing K11- and K63-linked ubiquitin chains, preventing APC/C-Cdh1-mediated degradation. USP10 and Cdh1 form a functional complex with ANLN in a non-competitive manner to balance ANLN levels. USP10 promotes contractile ring assembly at the cytokinetic furrow and cytokinesis through ANLN stabilization. Co-immunoprecipitation, ubiquitination assay (K11 and K63-specific), cytokinesis assay, USP10 inhibitor (F806), complex formation analysis with Cdh1 mutant Cell death and differentiation Medium 36526897
2019 USP10 interacts with TAK1 directly and promotes protection against cerebral ischemia-reperfusion injury. USP10 KO mice show elevated NF-κB signaling, JNK-MAPK activation, and increased apoptosis after cerebral I/R, demonstrating USP10's inhibitory role on TAK1-mediated inflammatory signaling. USP10 knockout mouse, cerebral I/R injury model, co-immunoprecipitation, NF-κB and JNK pathway analysis, apoptosis assay Biochemical and biophysical research communications Medium 31301769
2021 USP10 interacts with NEMO in macrophages; USP10 inhibition accelerates NEMO degradation. USP10 stabilizes NEMO by deubiquitination, maintaining NF-κB activation in LPS-induced sepsis. Suppressing USP10 attenuated inflammatory responses and improved survival in LPS-induced sepsis mice. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, spautin-1 inhibitor, NF-κB translocation assay, cytokine ELISA, in vivo sepsis model Inflammation research Medium 37436447
2023 USP10 binds to Axin1 via conserved motifs and stabilizes Axin1 through K48-linked deubiquitination. Additionally, USP10 physically tethers Axin1 and β-catenin and promotes phase separation for β-catenin suppression in a manner independent of enzymatic activity. In APC-truncated CRC, USP10 binds to β-catenin directly (via unstructured N-terminus) and increases β-catenin stability. Unbiased DUB screen, in vitro binding assay, computational modelling, ubiquitination assay (K48-specific), phase separation assay, USP10 enzymatic mutant, CRC organoid model, xenograft Cell chemical biology / Oncogene High 37611590 39443725
2019 TRAF4 interacts with USP10 and blocks p53 access to USP10, resulting in p53 destabilization and enhanced fibroblast proliferation in keloids. TRAF4 acts independently of its E3 ubiquitin ligase activity in this process. Co-immunoprecipitation, p53 ubiquitination assay, siRNA knockdown, rescue experiment (p53 knockdown), keloid fibroblast proliferation assay The Journal of investigative dermatology Medium 30940456
2022 USP10 deubiquitinates RUNX1 and stabilizes it, maintaining mesenchymal subtype properties in glioblastoma. USP10 knockdown inhibits RUNX1 and results in loss of mesenchymal properties. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, overexpression, in vivo xenograft, GBM subtype gene expression analysis Cell death & disease Medium 36949071
2022 USP10 deubiquitinates and stabilizes AID (activation-induced cytidine deaminase), which specifically stabilizes nuclear AID protein. USP10 translocates into the nucleus after AKT-mediated phosphorylation at T674 within its NLS domain. BCR and TLR1/2 signals synergistically promote this phosphorylation. USP10 deficiency in B cells decreased AID protein levels and reduced neutralizing antibody production after vaccination. Co-immunoprecipitation, ubiquitination assay, nuclear localization imaging, kinase assay, USP10-conditional B cell knockout, vaccination challenge Signal transduction and targeted therapy Medium 34983926
2023 USP10 directly interacts with PABPC1 and decreases K27/K29-linked ubiquitination of the RRM2 domain of PABPC1. Deubiquitinated PABPC1 couples more CLK2 mRNA and eIF4G1, increasing CLK2 translation efficiency and promoting pancreatic cancer tumor growth. Co-immunoprecipitation, mass spectrometry, ubiquitination assay (K27/K29-specific), polysome/mRNA association assay, in vivo xenograft and PDX model Cancer letters Medium 37757903
2023 USP10 interacts with and deubiquitinates MOF (KAT8) acetyltransferase at lysine 410, protecting it from proteasomal degradation. Stabilized MOF promotes H4K16ac enrichment at the ANXA2 promoter in a JUN-dependent manner, activating ANXA2/Wnt signaling and ESCC progression. Co-immunoprecipitation, ubiquitination assay, specific lysine mutagenesis (K410), H4K16ac ChIP, functional ESCC tumor model Oncogene Medium 38317006
2025 USP10 binds to XAB2 and deubiquitinates K48-linked polyubiquitination at K593 of XAB2, stabilizing it and preventing proteasomal degradation. Nuclear USP10 expression increases in CRC cells treated with oxaliplatin. Stabilized XAB2 upregulates ANXA2 transcriptionally by binding the ANXA2 promoter, promoting DNA damage repair and oxaliplatin resistance. Co-immunoprecipitation, mass spectrometry, ubiquitination site MS, ubiquitin assay, dual-luciferase reporter, ChIP-qPCR, xenograft model Journal of experimental & clinical cancer research Medium 40069750
2023 USP10 interacts with NICD1 (Notch1 intracellular domain) and deubiquitinates it, stabilizing NICD1 and promoting K11/K48-linked polyubiquitination-mediated degradation when disrupted by N1DARP microprotein. N1DARP competitively disrupts USP10-N1ICD interaction, accelerating N1ICD proteasomal degradation. Co-immunoprecipitation, ubiquitination assay (K11/K48-specific), competition binding assay, pancreatic cancer organoid model, KPC mouse model Cell discovery Medium 37714834
2020 USP10 interacts with CD36 scavenger receptor and stabilizes CD36 protein by cleaving poly-ubiquitin on CD36, promoting foam cell formation. USP10 inhibition promotes CD36 degradation and suppresses lipid uptake and foam cell formation by macrophages. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, Oil Red O staining, immunofluorescence Aging Low 33197885
2019 USP10 interacts with the EMT transcription factor Slug/SNAI2, identified in a genome-wide siRNA DUB screen, and mediates its proteasomal degradation. Genetic knockdown of USP10 decreases Slug levels and reduces cancer cell migration; overexpression elevates Slug and Vimentin. Genome-wide siRNA DUB screen, co-immunoprecipitation, protein stability assay, migration assay Biochemical and biophysical research communications Low 29803676
2023 DCAF7 acts as a scaffold protein facilitating the interaction between USP10 and G3BP1, leading to USP10-mediated removal of K48-linked ubiquitin moieties from Lys76 of G3BP1, preventing its proteasomal degradation and promoting stress granule-like structure formation and NPC chemoresistance. Co-immunoprecipitation, ubiquitination assay (K48-specific, K76 site mapping), siRNA knockdown, stress granule formation assay, in vitro and in vivo chemoresistance model Advanced science Medium 38973296
2023 USP10 interacts with ZEB1 and promotes its proteasomal degradation by modifying its ubiquitination. ERK phosphorylates USP10 at Ser236, impairing the USP10-ZEB1 interaction and enabling ZEB1 protein stabilization. MEK-ERK inhibition blocks USP10 phosphorylation and enhances USP10-ZEB1 interaction, suppressing ZEB1-mediated metastasis. Co-immunoprecipitation, ubiquitination assay, MEK inhibitor, USP10 phospho-site identification, colorectal cancer metastasis mouse tail-vein injection model Molecular cancer research Medium 36940483
2023 USP10 interacts with AMPK-phosphorylated state and potentiates deubiquitination and stabilization of Axin1 (K48-linked), linking the LKB1/AMPK axis to Wnt/β-catenin suppression. AMPK phosphorylation of USP10 also strengthens USP10 binding to β-catenin, supporting its phase transition and suppression. Co-immunoprecipitation, ubiquitination assay, AMPK kinase assay, phase separation assay, colorectal cancer organoid and xenograft model FEBS letters Medium 37873736
2019 USP10 interacts with NLRP7 and catalyzes its deubiquitination at K379, stabilizing NLRP7 protein and promoting colorectal cancer progression and M2 macrophage polarization via CCL2. Co-immunoprecipitation, mass spectrometry, ubiquitination assay, K379R mutagenesis, in vivo tumor model, macrophage polarization assay Journal of experimental & clinical cancer research Medium 33838681
2021 USP10 stabilizes GSK3β through deubiquitination; stabilized GSK3β in turn promotes ULK1 transcription by increasing ULK1 promoter activity, thereby driving ULK1-mediated autophagy, cell proliferation, and invasion in osteosarcoma. Co-immunoprecipitation, ubiquitination assay, ULK1 promoter reporter, GSK3β activity assay, siRNA knockdown, xenograft model Cell & bioscience Medium 39218913
2023 USP10 interacts with and deubiquitinates FOXQ1, promoting its protein stability. USP10-mediated FOXQ1 stabilization activates CREB5/NF-κB signaling to alleviate sepsis-induced acute kidney injury. Co-immunoprecipitation, ubiquitination assay, overexpression/knockdown, rescue experiment, in vivo CLP model Biochimica et biophysica acta. Molecular basis of disease Low 38960057
2024 AEG-1 recruits USP10 to remove K48-linked polyubiquitin chains at Lys425 of PARP1, preventing PARP1 proteasomal degradation and facilitating homologous recombination-mediated DNA double-strand break repair, conferring radioresistance in esophageal squamous cell carcinoma. Co-immunoprecipitation, ubiquitination assay (K48-specific, K425 site mapping), siRNA knockdown, DNA damage (γH2AX, comet assay), in vivo xenograft Cancer letters Medium 37838281
2024 NDR1 inhibits ubiquitination-mediated PD-L1 degradation via the deubiquitinase USP10; USP10 deubiquitinates PD-L1, stabilizing it and promoting immune escape in prostate cancer. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, CD8+ T cell co-culture model Cell communication and signaling Low 39227807
2023 KIF15 recruits USP10 to PGK1 and promotes USP10-mediated deubiquitination of PGK1, stabilizing PGK1 and enhancing glycolysis in pancreatic cancer. KIF15 interacts with both PGK1 and USP10 via its coil2 domain. Co-immunoprecipitation, mass spectrometry, ubiquitination assay, KIF15 truncation mapping, glycolytic capacity measurement (ECAR/OCR), in vivo xenograft Cell death & disease Medium 36807568
2020 Wu-5 directly interacts with and inactivates USP10 in vitro (IC50 = 8.3 µM), confirming its catalytic activity as a cysteine protease DUB. Overexpression of USP10 abrogates Wu-5-induced FLT3-ITD degradation and cell death, placing USP10 directly upstream of FLT3-ITD stability. In vitro enzymatic inhibition assay, overexpression rescue, cell viability assay Acta pharmacologica Sinica Medium 32694757
2024 PPM1B directly interacts with YBX1 and dephosphorylates YBX1 at serine 314; this dephosphorylation affects USP10-mediated deubiquitination of YBX1, resulting in decreased YBX1 protein stability. Thus USP10 deubiquitinates YBX1, and this is regulated by PPM1B-mediated phosphorylation state of YBX1. Co-immunoprecipitation, overexpression/silencing experiments, ubiquitination assay, S314 mutagenesis, PANoptosis assay, oxaliplatin resistance assay Cancer letters Low 38364962

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 693 21962518
2016 G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. The Journal of cell biology 517 27022092
2010 USP10 regulates p53 localization and stability by deubiquitinating p53. Cell 513 20096447
2013 USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation. Cell reports 166 24332849
2020 USP10 Promotes Proliferation of Hepatocellular Carcinoma by Deubiquitinating and Stabilizing YAP/TAZ. Cancer research 163 32217697
2016 Deubiquitination and Activation of AMPK by USP10. Molecular cell 134 26876938
2017 Inhibition of USP10 induces degradation of oncogenic FLT3. Nature chemical biology 124 28967922
2019 The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis. Cell death and differentiation 121 31748695
2020 The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation. Molecular cell 113 31981475
2011 USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation. Nucleic acids research 104 21245042
2022 Hypoxia-induced circWSB1 promotes breast cancer progression through destabilizing p53 by interacting with USP10. Molecular cancer 102 35351136
2009 The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells. The Journal of biological chemistry 102 19398555
2018 Ubiquitin-Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6. Hepatology (Baltimore, Md.) 101 29698567
2013 USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO. The EMBO journal 97 24270572
2015 TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. The Journal of biological chemistry 93 25861989
2021 NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer. Journal of experimental & clinical cancer research : CR 92 33838681
2019 Deubiquitinase USP10 regulates Notch signaling in the endothelium. Science (New York, N.Y.) 86 30975888
2020 When the chains do not break: the role of USP10 in physiology and pathology. Cell death & disease 82 33277473
2018 Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer. Molecular cancer research : MCR 82 29378906
2013 HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10. Blood 79 23775713
2019 USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia. Cell discovery 76 31044085
2018 Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF. Cell death and differentiation 76 29472714
2019 Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein. Molecular oncology 74 31721429
2017 USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN. Molecular and cellular biochemistry 71 28852924
2023 Stabilization of IGF2BP1 by USP10 promotes breast cancer metastasis via CPT1A in an m6A-dependent manner. International journal of biological sciences 69 36632454
2021 The deubiquitinase USP10 restores PTEN activity and inhibits non-small cell lung cancer cell proliferation. The Journal of biological chemistry 66 34416231
2018 USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma. Cancer letters 64 30056112
2005 The ubiquitin-specific protease USP10 modulates androgen receptor function. Molecular and cellular endocrinology 64 16368182
2022 HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway. Journal of experimental & clinical cancer research : CR 58 35277183
2020 Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis. Acta pharmacologica Sinica 58 33184448
2023 INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10. Circulation 57 37199168
2022 Structure and hepatoprotective activity of Usp10/NF-κB/Nrf2 pathway-related Morchella esculenta polysaccharide. Carbohydrate polymers 57 36657860
2020 The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53. Cell death & disease 55 32382008
2022 USP10 as a Potential Therapeutic Target in Human Cancers. Genes 52 35627217
2024 Modulation of YBX1-mediated PANoptosis inhibition by PPM1B and USP10 confers chemoresistance to oxaliplatin in gastric cancer. Cancer letters 49 38364962
2022 Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma. Cell death and differentiation 48 36526897
2018 USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway. American journal of physiology. Cell physiology 48 30281322
2016 RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation. Nature communications 47 27558965
2017 Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10. Journal of molecular biology 46 28587923
2019 TRAF4 Promotes Fibroblast Proliferation in Keloids by Destabilizing p53 via Interacting with the Deubiquitinase USP10. The Journal of investigative dermatology 45 30940456
2018 USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis. iScience 45 30469013
2016 Ubiquitin-specific Peptidase 10 (USP10) Deubiquitinates and Stabilizes MutS Homolog 2 (MSH2) to Regulate Cellular Sensitivity to DNA Damage. The Journal of biological chemistry 45 26975374
2014 MicroRNA-191 promotes pancreatic cancer progression by targeting USP10. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 45 25168367
2021 USP10 alleviates sepsis-induced acute kidney injury by regulating Sirt6-mediated Nrf2/ARE signaling pathway. Journal of inflammation (London, England) 43 34412625
2019 USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells. Scientific reports 43 31332267
2020 Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin. Journal of cellular and molecular medicine 42 32129945
2019 Long noncoding RNA Mirt2 upregulates USP10 expression to suppress hepatic steatosis by sponging miR-34a-5p. Gene 42 30898698
2014 Deubiquitination and stabilization of T-bet by USP10. Biochemical and biophysical research communications 42 24845384
2020 Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta pharmacologica Sinica 41 32694757
2023 A microprotein N1DARP encoded by LINC00261 promotes Notch1 intracellular domain (N1ICD) degradation via disrupting USP10-N1ICD interaction to inhibit chemoresistance in Notch1-hyperactivated pancreatic cancer. Cell discovery 39 37714834
2022 Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability. Military Medical Research 39 36163081
2010 The deubiquitinating enzyme USP10 regulates the endocytic recycling of CFTR in airway epithelial cells. Channels (Austin, Tex.) 37 20215869
2021 FSTL1-USP10-Notch1 Signaling Axis Protects Against Cardiac Dysfunction Through Inhibition of Myocardial Fibrosis in Diabetic Mice. Frontiers in cell and developmental biology 36 34957094
2019 USP10 regulates Musashi-2 stability via deubiquitination and promotes tumour proliferation in colon cancer. FEBS letters 36 30604502
2018 USP10 regulates the stability of the EMT-transcription factor Slug/SNAI2. Biochemical and biophysical research communications 36 29803676
2023 USP10 deubiquitinates RUNX1 and promotes proneural-to-mesenchymal transition in glioblastoma. Cell death & disease 35 36949071
2023 LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization. Journal of experimental & clinical cancer research : CR 32 37072811
2020 Inhibition of the deubiquitinase USP10 induces degradation of SYK. British journal of cancer 30 32015510
2023 USP10 Regulates ZEB1 Ubiquitination and Protein Stability to Inhibit ZEB1-Mediated Colorectal Cancer Metastasis. Molecular cancer research : MCR 29 36940483
2023 The AEG-1-USP10-PARP1 axis confers radioresistance in esophageal squamous cell carcinoma via facilitating homologous recombination-dependent DNA damage repair. Cancer letters 29 37838281
2021 The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity. The Journal of biological chemistry 29 33577797
2019 USP10 protects against cerebral ischemia injury by suppressing inflammation and apoptosis through the inhibition of TAK1 signaling. Biochemical and biophysical research communications 29 31301769
2025 USP10/XAB2/ANXA2 axis promotes DNA damage repair to enhance chemoresistance to oxaliplatin in colorectal cancer. Journal of experimental & clinical cancer research : CR 28 40069750
2019 G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10. Scientific reports 28 31501480
2017 The deubiquitylase USP10 regulates integrin β1 and β5 and fibrotic wound healing. Journal of cell science 28 28851806
2023 KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer. Cell death & disease 26 36807568
2023 Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma. Cancer letters 26 37757903
2021 Circ-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84. Bioengineered 26 34753388
2010 USP10: friend and foe. Cell 26 20144755
2024 DCAF7 Acts as A Scaffold to Recruit USP10 for G3BP1 Deubiquitylation and Facilitates Chemoresistance and Metastasis in Nasopharyngeal Carcinoma. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 25 38973296
2022 Limonin stabilises sirtuin 6 (SIRT6) by activating ubiquitin specific peptidase 10 (USP10) in cardiac hypertrophy. British journal of pharmacology 25 35727596
2021 Estrogen prevents cellular senescence and bone loss through Usp10-dependent p53 degradation in osteocytes and osteoblasts: the role of estrogen in bone cell senescence. Cell and tissue research 25 34223980
2024 Stabilization of MOF (KAT8) by USP10 promotes esophageal squamous cell carcinoma proliferation and metastasis through epigenetic activation of ANXA2/Wnt signaling. Oncogene 24 38317006
2022 USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID. Signal transduction and targeted therapy 24 34983926
2023 USP10 is a potential mediator for vagus nerve stimulation to alleviate neuroinflammation in ischaemic stroke by inhibiting NF-κB signalling pathway. Frontiers in immunology 22 37153558
2021 LncRNA GASAL1 promotes hepatocellular carcinoma progression by up-regulating USP10-stabilized PCNA. Experimental cell research 22 34914965
2021 USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity. The Journal of biological chemistry 21 34838592
2023 USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential. Cell chemical biology 20 37611590
2021 FoxO4 negatively modulates USP10 transcription to aggravate the apoptosis and oxidative stress of hypoxia/reoxygenation-induced cardiomyocytes by regulating the Hippo/YAP pathway. Journal of bioenergetics and biomembranes 20 34251583
2020 USP10 deletion inhibits macrophage-derived foam cell formation and cellular-oxidized low density lipoprotein uptake by promoting the degradation of CD36. Aging 20 33197885
2023 USP10 Contributes to Colon Carcinogenesis via mTOR/S6K Mediated HIF-1α but Not HIF-2α Protein Synthesis. Cells 19 37371055
2022 USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance. Molecular and cellular biology 19 35007165
2025 AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate cancer. Journal of experimental & clinical cancer research : CR 18 39806412
2024 The USP10/13 inhibitor, spautin-1, attenuates the progression of glioblastoma by independently regulating RAF-ERK mediated glycolysis and SKP2. Biochimica et biophysica acta. Molecular basis of disease 18 38857836
2023 Downregulated circPOKE promotes breast cancer metastasis through activation of the USP10-Snail axis. Oncogene 18 37717099
2022 CircCOL1A2 Sponges MiR-1286 to Promote Cell Invasion and Migration of Gastric Cancer by Elevating Expression of USP10 to Downregulate RFC2 Ubiquitination Level. Journal of microbiology and biotechnology 18 35791074
2021 USP10 exacerbates neointima formation by stabilizing Skp2 protein in vascular smooth muscle cells. The Journal of biological chemistry 18 34599966
2019 RNAi Screening-based Identification of USP10 as a Novel Regulator of Paraptosis. Scientific reports 18 30894572
2024 FOXP4-AS1 promotes CD8+ T cell exhaustion and esophageal cancer immune escape through USP10-stabilized PD-L1. Immunologic research 17 38687433
2024 Tuning Immune-Cold Tumor by Suppressing USP10/B7-H4 Proteolytic Axis Reinvigorates Therapeutic Efficacy of ADCs. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 17 39206932
2024 NDR1 mediates PD-L1 deubiquitination to promote prostate cancer immune escape via USP10. Cell communication and signaling : CCS 17 39227807
2024 Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop. Experimental & molecular medicine 16 38689092
2024 Recruitment of USP10 by GCS1 to deubiquitinate GRP78 promotes the progression of colorectal cancer via alleviating endoplasmic reticulum stress. Journal of experimental & clinical cancer research : CR 16 39267084
2022 USP10 Alleviates Palmitic Acid-induced Steatosis through Autophagy in HepG2 Cells. Journal of clinical and translational hepatology 16 36406315
2024 FOXQ1, deubiquitinated by USP10, alleviates sepsis-induced acute kidney injury by targeting the CREB5/NF-κB signaling axis. Biochimica et biophysica acta. Molecular basis of disease 15 38960057
2024 Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis. Cell & bioscience 15 39218913
2024 USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer. Oncogene 15 39443725
2023 USP10 regulates macrophage inflammation responses via stabilizing NEMO in LPS-induced sepsis. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 15 37436447
2023 The deubiquitinase USP10 mediates crosstalk between the LKB1/AMPK axis and Wnt/β-catenin signaling in cancer. FEBS letters 14 37873736
2020 USP10 Targeted Self-Deliverable siRNA to Prevent Scarring in the Cornea. Molecular therapy. Nucleic acids 14 32829179

Missed literature

Know a paper Affinage missed for USP10? Flag it for the maintainers and the community.

No submissions yet.