Affinage

JMJD6

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 · UniProt Q6NYC1

Length
403 aa
Mass
46.5 kDa
Annotated
2026-06-10
100 papers in source corpus 46 papers cited in narrative 45 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

JMJD6 is a nuclear Fe(II)- and 2-oxoglutarate-dependent dioxygenase of the JmjC family that couples post-translational modification of unstructured protein regions to the control of RNA processing and transcription (PMID:17947579, PMID:19574390, PMID:35930668). Its best-defined catalytic activity is C-5 lysyl hydroxylation, established by mass-spectrometric identification of hydroxylated lysines on the splicing factor U2AF65 and corroborated by crystallographic analysis showing an active-site geometry that favors lysyl hydroxylation, producing a distinct 5S-hydroxylysine stereochemistry (PMID:19574390, PMID:20684070, PMID:20685276, PMID:22238144); rigorous purified-enzyme kinetic and structural studies reassign JMJD6 as a lysyl hydroxylase and fail to detect arginyl demethylation in vitro (PMID:31147442). Systematic substrate profiling identifies ~150 hydroxylation sites on 48 substrates, concentrated in lysine-rich disordered regions of proteins associated with membraneless organelles, including extensive hydroxylation of BRD4 (PMID:35930668), and histone tails (H2A, H2B, H3, H4) where 5-hydroxylysine antagonizes acetylation and methylation (PMID:23303181). Through these activities JMJD6 governs alternative pre-mRNA splicing: it physically associates with U2AF65 and additional SR/RS-domain splicing factors and co-regulates splicing through both catalysis-dependent and -independent mechanisms, controlling specific transcripts including Flt1, Aire, AR-V7, and glutaminase isoforms (PMID:21300889, PMID:24914048, PMID:27899633, PMID:26531897, PMID:33822745, PMID:38488852). JMJD6 is also a central regulator of RNA Pol II promoter-proximal pause release: recruited by BRD4 to anti-pause enhancers via the BRD4 ET domain, it acts on H4R3me2s and on 7SK snRNA and proteolytically cleaves the 7SK snRNP component MePCE to liberate active P-TEFb (PMID:24360279, PMID:29176719, PMID:32048991). Beyond transcription elongation, JMJD6 modulates the DNA damage response by recruiting SIRT1 to double-strand breaks independently of its catalytic activity and by maintaining rDNA repeat integrity through interaction with Treacle (PMID:31358914, PMID:32598339), modifies p53 activity through K382 hydroxylation that promotes MDMX binding (PMID:24667498), and contributes to stress granule assembly, hematopoietic stem cell maintenance, and innate immune regulation (PMID:28972166, PMID:33560400, PMID:33684176). Mouse Jmjd6 deficiency causes intron-retention of Aire and spontaneous multi-organ autoimmunity, directly linking its splicing function to immune tolerance (PMID:26531897). A reported tyrosine kinase activity toward H2A.X Y39 and an arginine demethylase activity toward several substrates remain contested in light of the negative purified-enzyme results (PMID:30185813, PMID:31147442).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2007 High

    Established JMJD6 as a JmjC-family Fe(II)/2-OG dioxygenase and proposed its first molecular activity, addressing what enzymatic class it belongs to.

    Evidence In vitro and cell-based histone arginine demethylase assays with purified JMJD6

    PMID:17947579

    Open questions at the time
    • Arginine demethylase activity later not reproduced with purified enzyme
    • No structural basis provided for the assigned activity
  2. 2009 High

    Reassigned JMJD6's primary catalytic output to lysyl hydroxylation by identifying U2AF65 as a hydroxylation substrate, linking the enzyme to RNA splicing control.

    Evidence MS identification of hydroxylysine on U2AF65, in vitro hydroxylase assay, and cellular splicing reporters

    PMID:19574390

    Open questions at the time
    • Did not resolve which endogenous splicing programs depend on hydroxylation
    • Relationship to the earlier demethylase claim unresolved
  3. 2010 High

    Defined the structural and biochemical basis for substrate selection, showing active-site geometry favors C-5 lysyl hydroxylation and that JMJD6 binds single-stranded RNA, and located it in the nucleoplasm.

    Evidence X-ray crystallography with Ni(II) substitution, mutagenesis, nucleic-acid binding assays, and immunolocalization with KO comparison

    PMID:20679243 PMID:20684070 PMID:20685276 PMID:21060799

    Open questions at the time
    • Functional role of ssRNA binding not yet established
    • Did not reconcile structure with reported demethylase activity
  4. 2011 High

    Confirmed a distinct lysyl hydroxylase subfamily by stereochemical analysis and connected JMJD6 splicing function to angiogenesis through Flt1.

    Evidence NMR stereochemical assignment of 5S-hydroxylysine products and siRNA knockdown with reciprocal U2AF65 Co-IP and splicing rescue in endothelial cells

    PMID:21300889 PMID:22238144

    Open questions at the time
    • Whether U2AF65 hydroxylation directly drives Flt1 splicing not formally separated from binding
    • In vivo relevance not tested at this stage
  5. 2012 Medium

    Demonstrated histone H4 tail lysyl hydroxylation and that catalysis-dependent autohydroxylation drives homo-oligomerization, clarifying the enzyme's self-assembly.

    Evidence MALDI-TOF in vitro hydroxylase assays and oligomerization-domain mutagenesis

    PMID:22189873

    Open questions at the time
    • Negative arginine demethylation result from single lab
    • Functional significance of oligomerization in cells not established here
  6. 2013 High

    Connected JMJD6 to histone modification cross-talk and to RNA Pol II pause release, establishing its central transcription-elongation role.

    Evidence In vitro hydroxylase and competition assays plus ChIP-seq, RNA-seq, BRD4/P-TEFb Co-IP, and 7SK snRNA assays; subnuclear domain mapping by F2H and deletion

    PMID:23303181 PMID:23688307 PMID:24360279

    Open questions at the time
    • Direct enzymatic mechanism of 7SK 'decapping/demethylation' not fully defined
    • PolyS-dependent localization role in transcription not tested
  7. 2014 High

    Expanded the substrate and partner repertoire to p53, ERα, and SR/SR-related splicing factors, broadening JMJD6 into transcription and signaling control.

    Evidence Co-IP, in vitro hydroxylase/demethylation assays, MS site mapping, and splicing/reporter assays

    PMID:24498420 PMID:24667498 PMID:24914048

    Open questions at the time
    • ERα demethylation rests on limited methodological breadth
    • Whether RS-domain binding requires catalysis not resolved
  8. 2015 High

    Provided in vivo validation that JMJD6 splicing function controls immune tolerance (Aire) and developmental patterning (Wnt/Tcf7l1).

    Evidence Conditional and morpholino loss-of-function in mouse and Xenopus with splicing, protein, and phenotypic readouts plus Co-IP and rescue

    PMID:26157142 PMID:26531897

    Open questions at the time
    • Tcf7l1 derepression mechanism not tied to a catalytic activity
    • Generality of intron-retention phenotype to other transcripts unclear
  9. 2016 Medium

    Linked JMJD6 to oncogenic Myc/p53 regulation via promoter-level histone arginine modification.

    Evidence ChIP at the p19ARF promoter, gain/loss-of-function with p53 readouts, and xenografts

    PMID:27081402

    Open questions at the time
    • H4R3me2a demethylation activity contested by purified-enzyme studies
    • Single lab
  10. 2017 High

    Resolved how JMJD6 is recruited to chromatin and broadened its roles into stress granules, super-enhancer transcription, and innate immune/interferon control.

    Evidence NMR structure of the JMJD6-BRD4 ET-domain interface; Co-IP/MS, ChIP-seq, knockdown with phenotypic rescue across stress-granule, neuroblastoma, melanoma, and STAT1 systems

    PMID:19492415 PMID:28972166 PMID:29176719 PMID:29187213 PMID:29229759 PMID:29693039 PMID:31346162

    Open questions at the time
    • G3BP1/STAT1 demethylation relies on single-lab assays contested in vitro
    • Cell-surface localization function reported in only one cell type
  11. 2018 Medium

    Defined a Mediator-coupled enhancer-activation mechanism and reported a controversial intrinsic tyrosine kinase activity.

    Evidence MED12/CARM1 Co-IP, ChIP-seq, eRNA and xenograft assays; in vitro kinase assay with MS site mapping for H2A.X Y39

    PMID:29628309 PMID:30185813

    Open questions at the time
    • Tyrosine kinase activity is a novel single-lab claim not independently confirmed
    • Mechanism linking MED12 methylation to pause release incompletely defined
  12. 2019 High

    Sharpened the activity debate and dissected catalysis-dependent versus -independent functions via domain mapping.

    Evidence MS/NMR kinetics and crystallography on purified enzyme (no demethylation observed); systematic domain mutagenesis with ChIP and adipogenic differentiation

    PMID:31147442 PMID:31430278

    Open questions at the time
    • Reconciliation of in vitro-negative demethylation with cellular demethylation reports unresolved
    • AT-hook-mediated chromatin binding mechanism not structurally defined
  13. 2020 High

    Established catalysis-independent and proteolytic functions of JMJD6 in genome maintenance and elongation control.

    Evidence Microirradiation/live imaging with SIRT1 Co-IP and H4K16ac ChIP; rDNA integrity analyses with Treacle interactome; crystal structure plus in vitro/in vivo MePCE cleavage assays

    PMID:31358914 PMID:32048991 PMID:32598339

    Open questions at the time
    • Catalytic basis of MePCE proteolysis within a dioxygenase fold not mechanistically explained
    • How JMJD6 discriminates DSB versus nucleolar recruitment unclear
  14. 2021 High

    Demonstrated physiological roles in stem-cell maintenance, oncogenic splicing, and antiviral signaling, integrating JMJD6 into metabolism and immunity.

    Evidence Conditional KO mice with serial transplantation and metabolic/ROS rescue; RIP/mutagenesis for AR-V7 splicing; Co-IP/ubiquitination and KO mice for IRF3-RNF5 axis

    PMID:33560400 PMID:33684176 PMID:33822745

    Open questions at the time
    • Molecular target through which JMJD6 represses OXPHOS in HSCs not identified
    • Whether IRF3 control requires catalytic activity not established
  15. 2022 High

    Provided a global substrate map implicating JMJD6 in phase separation and added isoform-, lipid-, and migration-specific functions.

    Evidence MS substrate profiling (150 sites/48 substrates); IP-MS isoform interactome with splicing reporters; RBM39 Co-IP with ChIP-seq/lipid-droplet assays; HURP demethylation and Golgi-repositioning assays

    PMID:32927736 PMID:35764091 PMID:35930668 PMID:36250981

    Open questions at the time
    • Direct demonstration that hydroxylation alters phase separation not provided
    • HURP R122 demethylation depends on contested demethylase activity
  16. 2024 Medium

    Positioned JMJD6 as a hub coupling splicing to metabolism and proteostasis in cancer and stress adaptation.

    Evidence Co-IP, RNA-seq/splicing and metabolic assays for GLS/RBM39 in neuroblastoma; RNAi screen, HSF1 ChIP, and HSP70 demethylation assays

    PMID:38488852 PMID:38985769

    Open questions at the time
    • HSP70 R469 demethylation relies on contested activity
    • Direct enzymatic versus scaffolding contribution to GLS splicing not separated
  17. 2025 Medium

    Linked JMJD6 stability and modification to enhancer remodeling and ferroptosis regulation in cancer.

    Evidence Co-IP, ChIP-seq, enhancer-promoter loop analysis with SPOP/ATF4; PCAF acetylation, GST pulldown, MeRIP, and ferroptosis assays

    PMID:39903850 PMID:40011892

    Open questions at the time
    • Whether K375 acetylation modulates hydroxylase versus demethylase function unclear
    • Mediator recruitment mechanism for de novo enhancers not structurally defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • The central unresolved question is reconciling JMJD6's robust purified-enzyme lysyl hydroxylase and MePCE-cleavage activities with the numerous cellular arginine-demethylation and tyrosine-kinase claims that purified-enzyme assays have not reproduced.
  • No unifying structural model explains hydroxylase, proteolytic, and putative demethylase/kinase activities in one fold
  • Which catalytic activity underlies each in-cell phenotype is largely undetermined
  • Substrate-recruitment specificity across chromatin, splicing, and damage sites unexplained

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016491 oxidoreductase activity 6 GO:0140096 catalytic activity, acting on a protein 4 GO:0003723 RNA binding 3 GO:0016787 hydrolase activity 1 GO:0042393 histone binding 1
Localization
GO:0005730 nucleolus 3 GO:0005634 nucleus 2 GO:0005654 nucleoplasm 1
Pathway
R-HSA-74160 Gene expression (Transcription) 4 R-HSA-8953854 Metabolism of RNA 4 R-HSA-168256 Immune System 3 R-HSA-4839726 Chromatin organization 3 R-HSA-73894 DNA Repair 2
Partners
BRD4G3BP1MED12MEPCEP53RBM39SIRT1U2AF65
Complex memberships
7SK snRNPstress granule

Evidence

Reading pass · 45 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 JMJD6 is an iron- and 2-oxoglutarate-dependent dioxygenase (JmjC family) that demethylates histone H3 at arginine 2 (H3R2) and histone H4 at arginine 3 (H4R3) in both biochemical and cell-based assays. In vitro biochemical demethylase assay and cell-based assays with purified JMJD6 Science High 17947579
2009 JMJD6 catalyzes Fe(II)- and 2-oxoglutarate-dependent lysyl-5-hydroxylation of the splicing factor U2AF65, and this activity modulates alternative RNA splicing of specific endogenous and reporter genes. Mass spectrometry identification of hydroxylated lysine on U2AF65; in vitro hydroxylase assay; splicing reporter assays in cells with JMJD6 knockdown/overexpression Science High 19574390
2010 Crystal structure of the JMJD6 catalytic domain in complex with Ni(II) (substituting Fe(II)) reveals a double-stranded beta-helical fold; mutational studies show how active-site geometry favors C-5 lysyl hydroxylation rather than N-epsilon demethylation. X-ray crystallography; active-site mutagenesis Journal of Molecular Biology High 20684070 20685276
2010 JMJD6 binds efficiently to single-stranded RNA but not to single-stranded DNA, double-stranded RNA, or double-stranded DNA; the crystal structure reveals a novel substrate-binding groove and two positively charged surfaces with a stack of aromatic residues near the active center. X-ray crystallography; RNA/DNA binding assays; truncation analysis Proceedings of the National Academy of Sciences High 20679243
2010 Jmjd6 is distributed throughout the nucleoplasm outside heterochromatic regions, localizes occasionally to nucleoli, is excluded from the nucleus during mitosis and reappears in telophase, and forms homo-multimers. Jmjd6 does NOT demethylate histone lysine residues H3K4, H3K9, H3K27, H3K36, or H4K20. Immunolocalization; Western blot; comparison of histone methylation states in wildtype vs. Jmjd6-knockout cells; overexpression of active and inactive forms PLoS One Medium 21060799
2011 JMJD6-catalyzed hydroxylation of RNA-splicing regulatory protein fragments produces 5S-hydroxylysine, a stereochemistry distinct from collagen lysyl hydroxylases (which produce 5R products), indicating a distinct subfamily of lysyl hydroxylases. Amino acid analysis; NMR stereochemical assignment of hydroxylysine products from in vitro JMJD6 reactions ChemBioChem High 22238144
2011 Jmjd6 silencing impairs angiogenic functions of endothelial cells by altering splicing of VEGF-receptor 1 (Flt1), increasing levels of soluble Flt1 that inhibits angiogenesis. Jmjd6 physically interacts with splicing factor U2AF65 that binds Flt1 mRNA. siRNA knockdown; RT-PCR splicing assay; co-immunoprecipitation of Jmjd6 with U2AF65; rescue experiments with VEGF/PlGF or anti-sFlt1 antibodies Proceedings of the National Academy of Sciences High 21300889
2012 JMJD6 cannot demethylate histone arginine residues in vitro but does hydroxylate the histone H4 tail at lysine residues in a 2-OG- and Fe(II)-dependent manner. Homo-oligomerization of Jmjd6 requires its enzymatic (hydroxylase) activity and both N- and C-termini; Jmjd6 autodydroxylates its own N-terminus to form intermolecular covalent bonds mediating oligomerization. MALDI-TOF mass spectrometry in vitro enzymatic assay; mutational analysis of oligomerization domains Journal of Cellular Biochemistry Medium 22189873
2013 JMJD6 hydroxylates multiple lysyl residues of histone H3, H4, H2A, and H2B tails in vitro and in vivo. 5-Hydroxylysine on histones inhibits N-acetylation and N-methylation by acetyltransferase and methyltransferase in vitro, suggesting cross-talk between histone modifications. In vitro hydroxylase assay; amino acid composition analysis of histones from JMJD6-knockout mouse embryos; JMJD6 overexpression in HEK293 cells; in vitro competition assays with acetyltransferase/methyltransferase Journal of Biological Chemistry High 23303181
2013 JMJD6 and BRD4 co-occupy a unique cohort of distal enhancers (anti-pause enhancers, A-PEs) and regulate promoter-proximal Pol II pause release. BRD4-dependent JMJD6 recruitment to A-PEs mediates erasure of H4R3me2(s), which is read by 7SK snRNA; JMJD6 also decaps/demethylates 7SK snRNA, releasing the 7SK/HEXIM inhibitory complex and activating P-TEFb. ChIP-seq; RNA-seq; co-IP of JMJD6 with BRD4 and P-TEFb; 7SK snRNA demethylation/decapping assay; long-range chromatin interaction analysis Cell High 24360279
2013 The polyserine (polyS) domain of Jmjd6 mediates its subnuclear localization; Jmjd6 lacking the polyS domain localizes to the nucleolus (fibrillar centre) and interacts with nucleolar proteins. Homo-oligomerization of Jmjd6 occurs in cells and the structure of oligomers changes without the polyS domain. Live-cell imaging; co-immunoprecipitation; F2H (fluorescent 2-hybrid) assay; deletion mutagenesis Biochemical Journal Medium 23688307
2014 JMJD6 physically associates with p53 and acts as an alpha-ketoglutarate- and Fe(II)-dependent lysyl hydroxylase to hydroxylate p53 primarily at lysine 382. This hydroxylation antagonizes p53 acetylation, promotes p53 association with its negative regulator MDMX, and represses p53 transcriptional activity. Co-immunoprecipitation; in vitro hydroxylase assay; mass spectrometry identification of hydroxylation site; p53 acetylation assays; MDMX co-IP; reporter assays; JMJD6 knockdown/overexpression with phenotypic readouts PLoS Biology High 24667498
2014 Upon estrogenic stimulation, JMJD6 interacts with methylated estrogen receptor alpha (ERα) and acts as an arginine demethylase to demethylate ERα, regulating rapid extranuclear estrogenic responses. Co-immunoprecipitation; JMJD6 silencing combined with in vitro demethylation assay PLoS One Medium 24498420
2014 Jmjd6 interacts with multiple SR and SR-related proteins through their arginine-serine-rich (RS) domains, including U2AF65, Luc7L3, SRSF11, and Acinus S', but not the bona fide RS domain of SRSF1. Jmjd6 modifies constitutive splicing, binds RNA from a reporter plasmid, and co-localizes with nascent RNA. Co-immunoprecipitation; in vitro binding assay; splicing reporter assay; RNA binding assay; immunofluorescence co-localization with nascent RNA Nucleic Acids Research Medium 24914048
2015 Jmjd6, acting as a lysyl hydroxylase for splicing regulatory proteins, is required for efficient splicing of intron 2 of the Aire gene in medullary thymic epithelial cells; Jmjd6 deficiency results in retention of Aire intron 2, markedly reduced mature Aire protein, and spontaneous multi-organ autoimmunity in mice. Jmjd6 conditional knockout mouse; RT-PCR splicing analysis; Western blot of Aire protein; phenotypic analysis of autoimmunity Nature Communications High 26531897
2015 In Xenopus embryogenesis, Jmjd6 interacts with Tcf7l1 (Tcf3), competing with Groucho corepressor for the same binding region on Tcf7l1 to derepress Wnt target genes. Loss of Jmjd6 function causes anteroposterior body axis defects. Co-immunoprecipitation; reporter gene assays; morpholino loss-of-function in Xenopus embryos; rescue experiments Journal of Biological Chemistry Medium 26157142
2017 JMJD6 is a novel stress granule (SG) component that interacts with G3BP1 complexes. JMJD6 promotes G3BP1 arginine demethylation (monomethylation and asymmetric dimethylation at three Arg residues) and thereby promotes SG formation; knockdown of JMJD6 represses SG formation, and rescue requires catalytically active but not mutant JMJD6. Co-immunoprecipitation; mass spectrometry; JMJD6 knockdown; rescue with catalytically active vs. inactive JMJD6; immunofluorescence of SG markers Journal of Biological Chemistry Medium 28972166
2017 JMJD6 and BRD4 interact via the BRD4 extraterminal (ET) domain; NMR reveals a JMJD6 peptide (Lys84–Asn96) adopts an alpha-helix when bound to the ET domain through hydrophobic and electrostatic interactions. Single-stranded RNA binding by JMJD6 induces a conformational change that likely promotes this ET-domain interaction. NMR structure determination; mutagenesis; RNA binding assays Scientific Reports High 29176719
2017 JMJD6 forms protein complexes with N-Myc and BRD4 in neuroblastoma cells and is important for transcription of E2F2, N-Myc, and c-Myc. JMJD6 gene is associated with transcriptional super-enhancers. Co-immunoprecipitation; ChIP-seq; gene knockdown with transcriptional readouts Nature Communications Medium 31346162
2017 JMJD6 regulates the alternative splicing of PAK1, a MAPK pathway component, in melanoma cells; knockdown affects a panel of alternative splicing events as measured by RNA-seq. RNA-seq splicing analysis; JMJD6 knockdown; functional assays in melanoma cell lines Molecular Cancer Medium 29187213
2017 JMJD6 co-regulates alternative splicing events together with U2AF65; JMJD6 enzymatic activity (lysine hydroxylation of U2AF65) is required for a subset of co-regulated splicing events but not all, indicating both enzymatic activity-dependent and -independent mechanisms of splicing regulation. Validated in jmjd6 knockout mice. RASL-Seq splicing profiling; JMJD6/U2AF65 knockdown; JMJD6 knockout mice; co-IP; mutagenesis of catalytic residues Nucleic Acids Research High 27899633
2018 JMJD6 is required for ERα-bound active enhancer activation and RNA Pol II recruitment: JMJD6 interacts with MED12 in the mediator complex, is necessary for MED12 interaction with CARM1, and CARM1 methylates MED12 at multiple arginine sites to regulate chromatin binding, thereby enabling transcriptional pause release of estrogen target genes. Co-immunoprecipitation; ChIP-seq; enhancer RNA measurement; JMJD6 knockdown; CARM1 methylation assays; cell proliferation and xenograft assays Molecular Cell High 29628309
2018 JMJD6 has intrinsic tyrosine kinase activity and phosphorylates histone H2A.X at tyrosine 39 (H2A.XY39ph), using ATP and GTP as phosphate donors; high JMJD6 promotes autophagy in triple-negative breast cancer cells via regulation of autophagy-related gene expression through the H2A.XY39ph axis. In vitro kinase assay; mass spectrometry identification of phosphorylation site; JMJD6 knockdown with autophagy readouts; cell growth assays Oncogene Medium 30185813
2019 Biochemical (MS- and NMR-based kinetic assays) and structural (crystallographic) analyses with purified JMJD6 support assignment as a lysyl hydroxylase; the study did NOT observe N-methyl arginyl N-demethylation activity with purified JMJD6, calling into question its arginine demethylase activity. MS-based kinetic assay; NMR assay; X-ray crystallography; substrate fragment screening Journal of Biological Chemistry High 31147442
2019 JMJD6 homo-oligomerization does not require catalytic activity; the AT hook-like domain (mediating DNA/RNA interaction) is required for JMJD6 chromatin binding and function in adipogenic differentiation, whereas catalytic activity and the polyserine and sumoylation domains are dispensable. Domain mutagenesis; oligomerization assays; chromatin immunoprecipitation; adipogenic differentiation assays in JMJD6 mutant-rescued cells PLoS One Medium 31430278
2020 JMJD6 is recruited to DNA double-strand breaks (DSBs), controls spreading of histone ubiquitination and accumulation of repair proteins around DSBs, and promotes transcriptional silencing. Independently of catalytic activity, JMJD6 interacts with SIRT1 and recruits it to chromatin to downregulate H4K16ac around DSBs, modulating NHEJ and HR efficiency. Microirradiation with live imaging; co-immunoprecipitation of JMJD6 with SIRT1; ChIP for H4K16ac; NHEJ/HR reporter assays; catalytic mutant rescue Cell Death and Differentiation High 31358914
2020 JMJD6 cleaves methylphosphate capping enzyme (MePCE), a core component of the 7SK snRNP complex, via a novel proteolytic activity. This cleavage releases P-TEFb from the 7SK snRNP complex; downstream effect is phosphorylation of Pol II CTD. Crystal structure of JMJD6 bound to methyl-arginine was determined. Crystal structure of JMJD6 bound to methyl-arginine; in vitro and in vivo MePCE cleavage assays; binding assays; Jmjd6 KO and overexpression with Pol II CTD phosphorylation readout eLife High 32048991
2020 JMJD6 is rapidly recruited to nucleolar DNA damage sites and is required for relocation of rDNA into nucleolar caps, rDNA stability, and maintaining rDNA repeat integrity after irradiation. JMJD6 interacts with nucleolar protein Treacle and modulates its interaction with NBS1. Live-cell imaging after micro-irradiation; mass spectrometry interactome; JMJD6-deficient cells; rDNA repeat analysis by Southern blot/FISH PLoS Genetics Medium 32598339
2021 JMJD6 knockdown reduces recruitment of U2AF65 to AR pre-mRNA and reduces AR-V7 splice variant levels; mutagenesis indicates JMJD6 catalytic activity is required for AR-V7 generation. The JMJD6/U2AF65 axis thus controls AR-V7 splicing in prostate cancer. siRNA knockdown; mutagenesis of catalytic residues; RIP (RNA immunoprecipitation) of U2AF65 on AR pre-mRNA; RT-PCR for AR-V7; prostate cancer cell growth assays Cancer Research Medium 33822745
2021 JMJD6 negatively regulates antiviral innate immune signaling by recruiting the ubiquitin E3 ligase RNF5 to promote K48-linked ubiquitination and degradation of activated IRF3, thereby reducing type-I interferon production. Co-immunoprecipitation; ubiquitination assay; proteomic screen; JMJD6 KO via piggyBac transposon in mice; viral replication assays PLoS Pathogens Medium 33684176
2021 JMJD6 is essential for short- and long-term maintenance of the hematopoietic stem cell (HSC) pool; Jmjd6-deficient HSCs fail to expand after injury and lose self-renewal upon serial transplantation. JMJD6 represses mitochondrial OXPHOS, protein synthesis, p53 stabilization, and mTORC1 signaling in HSCs; ROS elevation from OXPHOS causally mediates HSC failure. Hematopoietic-specific conditional Jmjd6 KO mouse; serial transplantation; metabolic assays (mitochondrial respiration, ROS); N-acetyl-L-cysteine rescue Blood Advances High 33560400
2022 JMJD6 catalyzes lysine hydroxylation at 150 sites on 48 protein substrates identified by mass spectrometry, predominantly within unstructured lysine-rich regions. BRD4 is hydroxylated on 19 lysine sites. Nearly all identified substrates are associated with membraneless organelle formation, suggesting JMJD6 may regulate liquid-liquid phase separation. Mass spectrometry with lysine propionyl derivatization; nontryptic proteolysis; JMJD6-depleted vs. control cell comparison Proceedings of the National Academy of Sciences High 35930668
2022 JMJD6 interacts with RBM39 and co-occupies the DGAT1 gene promoter with H3K4me3 to induce DGAT1 expression, thereby promoting lipid droplet formation and ccRCC tumorigenesis. siRNA screen; ChIP-seq; RNA-seq; co-immunoprecipitation of JMJD6 with RBM39; JMJD6 KD with lipid droplet and tumor growth readouts Molecular Cell Medium 35764091
2022 JMJD6 demethylates HURP at R122, promoting Golgi apparatus repositioning (GR) and directional cell migration via a NF-κB-induced centrosome repositioning and subsequent Cdc42 upregulation cascade; PRMT5 methylation of HURP R122 opposes this. Co-immunoprecipitation; HURP methylation assays; JMJD6 KD; Golgi repositioning assays; cell migration assays; mechanistic epistasis using methylation-mimic/deficiency mutants Journal of Cellular Physiology Medium 36250981
2022 JMJD6 regulates splicing of its own pre-mRNA to produce isoforms (JMJD6-2 and JMJD6-Ex5) with distinct C-terminal sequences and different interaction partners; JMJD6-2 interacts with SR-like splicing factors (RS-domain proteins) while JMJD6-Ex5 interacts with SMN complex, hnRNPs, UBF, and FCP1. JMJD6-2 but not JMJD6-Ex5 inhibits exon inclusion in a splicing reporter. Immunoprecipitation followed by LC-MS/MS; HIV-based splicing reporter assay; siRNA knockdown; RT-PCR isoform analysis International Journal of Molecular Sciences Medium 32927736
2023 JMJD6 interacts with NF-κB p65 in the cytoplasm and demethylates p65 at arginine 149 (R149), inhibiting nuclear translocation of p65 and thereby suppressing NF-κB signaling and protecting against pathological cardiac hypertrophy. Co-immunoprecipitation of JMJD6 with p65; in vitro/in vivo demethylation assays; cardiac-specific JMJD6 overexpression in rats; sgRNA-mediated JMJD6 depletion; echocardiography; hypertrophic gene expression assays Acta Pharmacologica Sinica Medium 37186122
2024 JMJD6 acts as a hub connecting pre-mRNA splicing and glutamine metabolism in MYC-driven neuroblastoma: it physically interacts with RNA-binding proteins involved in splicing and protein homeostasis, and controls alternative splicing of glutaminase (GLS) isoforms KGA and GAC (rate-limiting enzymes of glutaminolysis). JMJD6 also complexes with RBM39, linking it to sensitivity to the splicing inhibitor indisulam. Co-immunoprecipitation; RNA-seq/splicing analysis; metabolic assays; cell transformation assays; indisulam treatment with JMJD6-dependent readout eLife Medium 38488852
2024 HSF1 directly binds JMJD6 gene and promotes its transcription; JMJD6 in turn reduces HSP70 R469 monomethylation to disrupt HSP70-HSF1 repressive complexes, enabling enhanced HSF1 activation in a positive feedback circuit mediating cellular adaptation to proteotoxic stress. Genome-wide RNAi screen with HSR reporter; ChIP assay for HSF1 at JMJD6 locus; JMJD6-mediated HSP70 demethylation assay; co-immunoprecipitation Proceedings of the National Academy of Sciences Medium 38985769
2025 SPOP mutants impair proteasomal degradation of JMJD6; elevated JMJD6 and ATF4 coordinate enhancer-promoter loop interactions to stimulate glutathione biosynthesis pathway genes (SLC7A11, GCLM, ME1). JMJD6 recruits mediator subunits (Med1/Med14) to assemble de novo enhancers at these loci, conferring ferroptosis resistance independently of androgen receptor. Co-immunoprecipitation; ChIP-seq; enhancer-promoter loop analysis; JMJD6 depletion; preclinical tumor models with ferroptosis inducers Cancer Research Medium 39903850
2025 JMJD6 is acetylated at lysine 375 by the acetyltransferase PCAF; K375 acetylation weakens JMJD6 arginine demethylase activity, enhances METTL14 expression, increases m6A modification of SLC3A2, and thereby promotes ferroptosis sensitivity in lung cancer cells. Co-immunoprecipitation; GST pulldown; in vitro acetylation assay; ChIP; MeRIP (m6A sequencing); functional ferroptosis assays; JMJD6 overexpression/knockdown Journal of Translational Medicine Medium 40011892
2017 JMJD6 suppresses Myc-induced apoptosis through inhibition of p19ARF mRNA and protein, leading to reduced p53 levels; JMJD6 binds the p19ARF promoter and exerts its inhibitory function through demethylation of H4R3me2a at this promoter. Chromatin immunoprecipitation at p19ARF promoter; JMJD6 overexpression/knockdown with p19ARF/p53 readouts; cell viability assays under stress; xenograft tumor assays Clinical Epigenetics Medium 27081402
2009 Endogenous Jmjd6 is expressed at the cell surface of immature monocyte-like THP-1 cells activated with PMA and translocates to the nucleus upon macrophage differentiation; antibody blockade of surface Jmjd6 suppresses phagocytosis of dead cells in immature macrophages. Immunocytochemistry; antibody blocking of endogenous surface Jmjd6; phagocytosis assay; time-course subcellular fractionation Journal of Cellular Physiology Medium 19492415
2017 JMJD6 demethylates STAT1 arginine methylation, suppressing IFNα-induced interferon-stimulated gene (ISG) activation; overexpression of JMJD6 suppressed STAT1 methylation and ISG activation, while JMJD6 silencing enhanced both. JMJD6 overexpression/knockdown; STAT1 methylation assay; ISG expression measurement; HCV RNA quantification; in vivo mouse model Cellular and Molecular Gastroenterology and Hepatology Medium 29693039
2017 JMJD6 binds to the HOTAIR promoter region (−123 to −103 bp) and induces HOTAIR transcription; a catalytically dead JMJD6 mutant (H187A) can bind the HOTAIR promoter but fails to activate transcription, demonstrating enzymatic activity-dependent transcriptional regulation. ChIP; EMSA; deletion constructs of HOTAIR promoter; luciferase reporter; JMJD6 overexpression/siRNA in multiple cell lines; catalytic mutant analysis Biochemical Journal Medium 29229759
2020 Fibronectin is a novel substrate of JMJD6-mediated lysyl hydroxylation; JMJD6-catalyzed hydroxylation of fibronectin precedes its glycosylation, deposition, and degradation in placental mesenchymal cells. MALDI-TOF mass spectrometry identification of fibronectin as JMJD6 substrate; JMJD6 knockdown recapitulating fibronectin accumulation phenotype; iron rescue (Hinokitiol) experiments Frontiers in Cell and Developmental Biology Medium 34055782

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 JMJD6 is a histone arginine demethylase. Science (New York, N.Y.) 517 17947579
2013 Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. Cell 329 24360279
2009 Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science (New York, N.Y.) 326 19574390
2011 Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1. Proceedings of the National Academy of Sciences of the United States of America 123 21300889
2014 JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. PLoS biology 116 24667498
2004 Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC developmental biology 116 15615595
2013 Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6). The Journal of biological chemistry 111 23303181
2010 Interaction of JMJD6 with single-stranded RNA. Proceedings of the National Academy of Sciences of the United States of America 90 20679243
2015 The oxygenase Jmjd6--a case study in conflicting assignments. The Biochemical journal 77 25997831
2018 JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex. Molecular cell 75 29628309
2019 JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma. Nature communications 74 31346162
2010 Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. Journal of molecular biology 70 20684070
2014 JMJD6 regulates ERα methylation on arginine. PloS one 69 24498420
2016 PCAF-mediated acetylation of transcriptional factor HOXB9 suppresses lung adenocarcinoma progression by targeting oncogenic protein JMJD6. Nucleic acids research 67 27613418
2017 Histone arginine demethylase JMJD6 is linked to stress granule assembly through demethylation of the stress granule-nucleating protein G3BP1. The Journal of biological chemistry 66 28972166
2010 Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. PloS one 62 21060799
2018 JMJD6 promotes hepatocellular carcinoma carcinogenesis by targeting CDK4. International journal of cancer 60 30125344
2014 Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins. Nucleic acids research 57 24914048
2013 High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 57 23595221
2017 JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component. Molecular cancer 56 29187213
2016 The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis. Clinical epigenetics 56 27081402
2010 Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6. Journal of molecular biology 55 20685276
2018 JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity. Oncogene 49 30185813
2011 The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues. Chembiochem : a European journal of chemical biology 49 22238144
2022 An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma. Molecular cell 48 35764091
2015 Role of JMJD6 in Breast Tumourigenesis. PloS one 48 25951181
2015 Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties. Carcinogenesis 48 26645717
2017 Jmjd6, a JmjC Dioxygenase with Many Interaction Partners and Pleiotropic Functions. Frontiers in genetics 47 28360925
2017 MiR-770 inhibits tumorigenesis and EMT by targeting JMJD6 and regulating WNT/β-catenin pathway in non-small cell lung cancer. Life sciences 45 28882645
2012 The hydroxylation activity of Jmjd6 is required for its homo-oligomerization. Journal of cellular biochemistry 43 22189873
2019 Jumonji domain-containing 6 (JMJD6) identified as a potential therapeutic target in ovarian cancer. Signal transduction and targeted therapy 42 31637004
2017 JMJD6 and U2AF65 co-regulate alternative splicing in both JMJD6 enzymatic activity dependent and independent manner. Nucleic acids research 41 27899633
2021 JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer. Cancer research 40 33822745
2020 Mechanistic basis and efficacy of targeting the β-catenin-TCF7L2-JMJD6-c-Myc axis to overcome resistance to BET inhibitors. Blood 40 32068780
2017 Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4. Scientific reports 39 29176719
2008 Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins. BMC genomics 38 18564434
2013 The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization. The Biochemical journal 36 23688307
2014 Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection. Scientific reports 35 25219359
2013 Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF(65.). Blood cells, molecules & diseases 31 23787363
2022 Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6. Proceedings of the National Academy of Sciences of the United States of America 30 35930668
2015 Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus. Nature communications 30 26531897
2019 Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6. The Journal of biological chemistry 29 31147442
2020 JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes. eLife 28 32048991
2022 A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America 26 35969736
2020 Both EZH2 and JMJD6 regulate cell cycle genes in breast cancer. BMC cancer 26 33246425
2017 Bifunctional Enzyme JMJD6 Contributes to Multiple Disease Pathogenesis: New Twist on the Old Story. Biomolecules 26 28587176
2016 Role of Jumonji C-domain containing protein 6 (JMJD6) in infectivity of foot-and-mouth disease virus. Virology 26 26896934
2022 Role of the Epigenetic Modifier JMJD6 in Tumor Development and Regulation of Immune Response. Frontiers in immunology 25 35359945
2018 LncRNA-MALAT1 promotes CPC proliferation and migration in hypoxia by up-regulation of JMJD6 via sponging miR-125. Biochemical and biophysical research communications 25 29605300
2021 Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma. Clinical and translational medicine 24 33634984
2017 Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism. Cellular and molecular gastroenterology and hepatology 23 29693039
2018 Compromised JMJD6 Histone Demethylase Activity Affects VHL Gene Repression in Preeclampsia. The Journal of clinical endocrinology and metabolism 22 29373688
2017 Inhibition of JMJD6 expression reduces the proliferation, migration and invasion of neuroglioma stem cells. Neoplasma 22 28592121
2021 JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination. PLoS pathogens 21 33684176
2020 JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage. PLoS genetics 21 32598339
2019 JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity. Cell death and differentiation 21 31358914
2018 JMJD6 exerts function in neuropathic pain by regulating NF‑κB following peripheral nerve injury in rats. International journal of molecular medicine 19 29620141
2018 Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. Frontiers in genetics 19 30619488
2023 JMJD6-BRD4 complex stimulates lncRNA HOTAIR transcription by binding to the promoter region of HOTAIR and induces radioresistance in liver cancer stem cells. Journal of translational medicine 18 37880710
2025 JMJD6 K375 acetylation restrains lung cancer progression by enhancing METTL14/m6A/SLC3A2 axis mediated cell ferroptosis. Journal of translational medicine 17 40011892
2009 Endogenous Jmjd6 gene product is expressed at the cell surface and regulates phagocytosis in immature monocyte-like activated THP-1 cells. Journal of cellular physiology 17 19492415
2018 JMJD6 induces HOTAIR, an oncogenic lincRNA, by physically interacting with its proximal promoter. The Biochemical journal 16 29229759
2019 In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment. ACS medicinal chemistry letters 15 31857835
2021 LINC00839/miR-519d-3p/JMJD6 axis modulated cell viability, apoptosis, migration and invasiveness of lung cancer cells. Folia histochemica et cytobiologica 14 34734406
2015 JmjC Domain-containing Protein 6 (Jmjd6) Derepresses the Transcriptional Repressor Transcription Factor 7-like 1 (Tcf7l1) and Is Required for Body Axis Patterning during Xenopus Embryogenesis. The Journal of biological chemistry 14 26157142
2021 JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. Blood advances 13 33560400
2024 Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor. eLife 12 38488852
2023 JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit. Acta pharmacologica Sinica 12 37186122
2022 Oxygen-dependent regulation of E3(SCF)ubiquitin ligases and a Skp1-associated JmjD6 homolog in development of the social amoeba Dictyostelium. The Journal of biological chemistry 12 35933019
2021 Discovery of a new class of JMJD6 inhibitors and structure-activity relationship study. Bioorganic & medicinal chemistry letters 12 33991627
2025 JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer. Cancer research 11 39903850
2021 The role of JMJD6/U2AF65/AR-V7 axis in castration-resistant prostate cancer progression. Cancer cell international 11 33430885
2020 Differential regulation of sFlt-1 splicing by U2AF65 and JMJD6 in placental-derived and endothelial cells. Bioscience reports 11 32039444
2020 LncRNA ZFPM2-AS1 aggravates the malignant development of breast cancer via upregulating JMJD6. European review for medical and pharmacological sciences 11 33215431
2019 Livin promotes colon cancer progression by regulation of H2A.XY39ph via JMJD6. Life sciences 11 31445935
2017 Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 11 28790175
2024 An HSF1-JMJD6-HSP feedback circuit promotes cell adaptation to proteotoxic stress. Proceedings of the National Academy of Sciences of the United States of America 9 38985769
2023 JMJD6 Shapes a Pro-tumor Microenvironment via ANXA1-Dependent Macrophage Polarization in Breast Cancer. Molecular cancer research : MCR 9 36867680
2021 JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration. Frontiers in cell and developmental biology 9 34055782
2018 Histone demethylase JMJD6 regulates cellular migration and proliferation in adipose-derived mesenchymal stem cells. Stem cell research & therapy 9 30092848
2017 Insights into Jumonji C-domain containing protein 6 (JMJD6): a multifactorial role in foot-and-mouth disease virus replication in cells. Virus genes 9 28364140
2016 Pathogenesis and micro-anatomic characterization of a cell-adapted mutant foot-and-mouth disease virus in cattle: Impact of the Jumonji C-domain containing protein 6 (JMJD6) and route of inoculation. Virology 9 26914509
2025 Targeting JMJD6/PPARγ/GPX4 axis overcomes ferroptosis resistance and enhances therapeutic efficacy in hepatocellular carcinoma. Oncogene 8 41028904
2019 Promotion of adipogenesis by JMJD6 requires the AT hook-like domain and is independent of its catalytic function. PloS one 8 31430278
2022 The Novel Protease Activities of JMJD5-JMJD6-JMJD7 and Arginine Methylation Activities of Arginine Methyltransferases Are Likely Coupled. Biomolecules 7 35327545
2022 JMJD6 orchestrates a transcriptional program in favor of endocrine resistance in ER+ breast cancer cells. Frontiers in endocrinology 7 36419768
2019 KRas-ERK signalling promotes the onset and maintenance of uveal melanoma through regulating JMJD6-mediated H2A.X phosphorylation at tyrosine 39. Artificial cells, nanomedicine, and biotechnology 7 31736361
2023 c-Jun-mediated JMJD6 restoration enhances resistance of liver cancer to radiotherapy through the IL-4-activated ERK pathway. Cell biology international 6 37070787
2020 Analysis of Amino Acid Mutations of the Foot-and-Mouth Disease Virus Serotype O Using both Heparan Sulfate and JMJD6 Receptors. Viruses 6 32927791
2020 JMJD6 Regulates Splicing of Its Own Gene Resulting in Alternatively Spliced Isoforms with Different Nuclear Targets. International journal of molecular sciences 5 32927736
2018 Normalizing JMJD6 Expression in Rat Spinal Dorsal Horn Alleviates Hyperalgesia Following Chronic Constriction Injury. Frontiers in neuroscience 5 30131674
2025 JMJD6-driven epigenetic activation of COL4A2 reprograms glioblastoma vascularization via integrin α1β1-dependent PI3K/MAPK signaling. Acta neuropathologica communications 4 40993804
2022 MiR-298 suppresses the malignant progression of osteosarcoma by targeting JMJD6. European review for medical and pharmacological sciences 4 35442509
2022 Design and synthesis of N-(1-(6-(substituted phenyl)-pyridazin-3-yl)-piperidine-3-yl)-amine derivatives as JMJD6 inhibitors. Bioorganic chemistry 4 36116323
2022 The JMJD6/HURP axis promotes cell migration via NF-κB-dependent centrosome repositioning and Cdc42-mediated Golgi repositioning. Journal of cellular physiology 4 36250981
2021 Computational and Mass Spectrometry-Based Approach Identify Deleterious Non-Synonymous Single Nucleotide Polymorphisms (nsSNPs) in JMJD6. Molecules (Basel, Switzerland) 4 34361805
2024 JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases. International journal of molecular sciences 3 38732153
2024 The long non-coding RNA lncRNA-DRNR enhances infectious bronchitis virus replication by targeting chicken JMJD6 and modulating interferon-stimulated genes expression via the JAK-STAT signalling pathway. Veterinary research 3 39501382
2022 Impact of JMJD6 on intrahepatic cholangiocarcinoma. Molecular and clinical oncology 3 35911665
2022 Jmjd6 regulates ES cell homeostasis and enhances reprogramming efficiency. Heliyon 2 35846449

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