Affinage

RBMX

RNA-binding motif protein, X chromosome · UniProt P38159

Length
391 aa
Mass
42.3 kDa
Annotated
2026-06-10
47 papers in source corpus 22 papers cited in narrative 24 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RBMX (hnRNP G) is a nuclear RNA-binding protein that couples co-transcriptional pre-mRNA splicing regulation to genome maintenance (PMID:31445886, PMID:22344029). It acts as an m6A reader that engages the phosphorylated CTD of RNA Polymerase II through RGG motifs in its low-complexity region, co-transcriptionally associating with RNAPII and nascent pre-mRNA so that m6A near splice sites tunes RBMX binding and exon inclusion transcriptome-wide (PMID:31445886); functionally distinct domains support this, including an N-terminal RRM, a central nascent-transcript targeting domain that recruits RBMX to active transcription units, and a C-terminal auxiliary RNA-binding domain (PMID:21327109). RBMX directs specific splicing outcomes largely through direct protein-protein contacts with splicing factors rather than by RNA binding alone: it promotes SMN2 exon 7 inclusion via Htra2-beta1 (PMID:12165565), cooperates with SRSF1 (in a manner controlled by PRMT5 methylation of its RGG/RG motif) to govern MDM4 exon 6 inclusion and downstream p53 signaling (PMID:34260915), partners with U2AF65 to control HPV16 transcript splicing (PMID:35357488), and antagonizes hnRNP A1 to shift PKM splicing toward PKM1 and restrain glycolysis (PMID:33564070). In parallel, RBMX safeguards genome integrity: it accumulates at DNA double-strand breaks in a PARP1-dependent manner to promote BRCA2 expression and homologous recombination (PMID:22344029), binds ssDNA at sites adjacent to RPA to recruit TopBP1 and activate ATR on repetitive DNA during replication stress (PMID:32494026), and maintains centromeric sister chromatid cohesion by associating with cohesin subunits Scc1/Smc3 and acting as a Wapl inhibitor (PMID:22832223), with satellite I noncoding RNA stabilizing RBMX within a centromeric ncRNP complex (PMID:29383807). RBMX also regulates RNA metabolism beyond splicing, promoting TERRA degradation by bridging it to the nuclear exosome via ZCCHC8 and thereby limiting telomeric R-loops (PMID:37756323), and controlling nascent transcription of the CBX5/HP1α locus to support leukemic cell survival (PMID:34458856). Its activity is modulated post-translationally by PRMT5-mediated arginine methylation (PMID:34260915) and by (de)SUMOylation (PMID:35357488). RBMX and its retrogene RBMXL1 share partners and act redundantly, with RBMXL1 buffering RBMX loss in brain development.

Mechanistic history

Synthesis pass · year-by-year structured walk · 21 steps
  1. 2002 High

    Established that RBMX achieves splice-site specificity through protein-protein interaction rather than nonspecific RNA binding, defining its mode of action as a splicing regulator.

    Evidence in vivo splicing assays with hnRNP-G deletion mutants and Htra2-beta1 interaction analysis on SMN2 exon 7

    PMID:12165565

    Open questions at the time
    • Did not define the RNA elements or genome-wide targets
    • Mechanism of co-transcriptional recruitment unaddressed
  2. 2006 Medium

    Showed RBMX can act at the DNA/promoter level, regulating SREBP-1c transcription in response to dietary fructose, broadening its role beyond RNA processing.

    Evidence MALDI-TOF identification, EMSA with anti-RBMX antibody, and SREBP-1c promoter gain/loss-of-function in hepatoma cells

    PMID:17188681

    Open questions at the time
    • Direct DNA binding versus complex recruitment not resolved
    • No structural basis for promoter recognition
  3. 2009 Medium

    Identified SAFB1 as an RBMX partner required for RBMX-driven Srebp-1c promoter activity, providing a protein-complex mechanism for the transcriptional role.

    Evidence yeast two-hybrid, Co-IP, ChIP, and promoter activity assays

    PMID:19403048

    Open questions at the time
    • Generality of SAFB1 dependence at other loci unknown
    • Interplay with RBMX RNA-binding function unaddressed
  4. 2010 Medium

    Resolved RBMX into functionally distinct domains, separating RNA-sequence recognition from recruitment to active transcription units.

    Evidence domain deletion analysis with injection into Xenopus oocytes and RNA-binding assays

    PMID:21327109

    Open questions at the time
    • Structural model of the NTD lacking
    • How recruitment integrates with splice-site selection unclear
  5. 2011 Medium

    Extended the splicing-factor interaction model by showing RBMX represses tau exon 10 through a complex with SRp75, relevant to FTDP-17.

    Evidence co-transfection splicing assays, Co-IP, and RNAi

    PMID:21723381

    Open questions at the time
    • Direct RNA contacts on the tau intron not mapped
    • Single-cell-system validation only
  6. 2012 High

    Revealed an unanticipated genome-maintenance role: RBMX accumulates at DSBs in a PARP1-dependent manner and promotes HR via BRCA2 expression.

    Evidence genome-wide siRNA screen, lesion localization imaging, and HR assays with domain analysis

    PMID:22344029

    Open questions at the time
    • Whether BRCA2 regulation is transcriptional or splicing-based not fully resolved
    • RNA-binding requirement at lesions unclear
  7. 2012 High

    Defined RBMX as a centromeric cohesion factor, linking it to faithful chromosome segregation through Wapl inhibition.

    Evidence RNAi depletion, reciprocal Co-IP with Scc1/Smc3 and Wapl, chromosome morphology, and Wapl epistasis

    PMID:22832223

    Open questions at the time
    • Direct biochemical basis of Wapl inhibition unknown
    • Whether RNA binding contributes to cohesion not tested
  8. 2018 Medium

    Connected RBMX cohesion function to a noncoding RNP, showing satellite I RNA stabilizes RBMX and Sororin in an M-phase centromere complex.

    Evidence LC/MS purification of satellite I ncRNP, RNAi, cell-cycle synchronization, and immunofluorescence

    PMID:29383807

    Open questions at the time
    • Stoichiometry and architecture of the ncRNP undefined
    • Single-lab; limited orthogonal validation
  9. 2019 High

    Unified RBMX splicing activity under a co-transcriptional, m6A-reader framework, mechanistically linking RNA modification, RNAPII CTD binding, and exon inclusion genome-wide.

    Evidence in vitro CTD binding, CLIP-seq, ChIP-seq, RGG-motif mutagenesis, and transcriptome-wide splicing analysis

    PMID:31445886

    Open questions at the time
    • Direct m6A-binding affinity/structural basis not defined
    • How m6A reading is integrated with specific splicing-factor partners unresolved
  10. 2019 High

    Clarified that RBMX binding to the lncRNA NORAD is dispensable for NORAD-mediated genomic stability, refining which RBMX RNA interactions are functionally relevant.

    Evidence RNA FISH, cellular fractionation, and genetic rescue with PUM- and RBMX-binding-mutant NORAD

    PMID:31343408

    Open questions at the time
    • Does not exclude RBMX-NORAD roles in other contexts
    • No direct test of RBMX binding kinetics on NORAD
  11. 2020 High

    Defined a distinct ATR-activating pathway in which ssDNA-bound RBMX recruits TopBP1 on repetitive DNA, independent of the canonical ssDNA-dsDNA junction/9-1-1 route.

    Evidence super-resolution STORM, ChIP-seq, in vitro ssDNA binding, RNAi, and replication-stress/SCE assays

    PMID:32494026

    Open questions at the time
    • How RBMX selects repetitive loci versus general ssDNA unclear
    • Relationship to RBMX splicing function unaddressed
  12. 2021 High

    Established PRMT5 methylation of the RBMX RGG/RG motif as a switch controlling RBMX/SRSF1 complex assembly and MDM4 splicing, tying RBMX to p53 regulation and Shashi-XLID.

    Evidence PRMT5 methylation assay, RBMX/SRSF1 Co-IP, SRSF1-MDM4 RIP, minigene splicing, and CRISPR isogenic hiPSCs with transcriptomics

    PMID:34260915

    Open questions at the time
    • Other methylation-dependent splicing targets not mapped
    • Stoichiometry of higher-order RBMX/SRSF1 assemblies undefined
  13. 2021 High

    Showed RBMX (with RBMXL1) controls nascent CBX5/HP1α transcription to support leukemic cell growth, identifying a transcription-level effector relevant to myeloid malignancy.

    Evidence RIP, chromatin accessibility, nascent transcription analysis, and CBX5 rescue in murine/human AML cells

    PMID:34458856

    Open questions at the time
    • Mechanism by which RBMX engages the CBX5 locus unclear
    • Direct DNA versus nascent-RNA contact not distinguished
  14. 2021 Medium

    Demonstrated RBMX competitively antagonizes hnRNP A1 at PKM exon 9 to favor PKM1, linking RBMX splicing control to metabolic and tumor-suppressive output.

    Evidence RBMX/hnRNP A1 Co-IP, PKM splicing analysis, and RNAi/overexpression with in vitro and in vivo assays

    PMID:33564070

    Open questions at the time
    • Direct RNA-binding competition not biochemically reconstituted
    • Single cancer context
  15. 2022 Medium

    Mapped a splicing-enhancing region of RBMX acting via U2AF65 on HPV16 pre-mRNA and showed SUMOylation status, modulated by DDR, tunes these interactions.

    Evidence splicing-enhancer mutagenesis, RNA binding, U2AF65 Co-IP, domain deletion, and sumoylation assays in keratinocytes

    PMID:35357488

    Open questions at the time
    • SUMO sites on RBMX not pinpointed
    • Generality beyond viral transcripts untested
  16. 2023 Medium

    Identified RBMX as a factor that delivers TERRA to the nuclear exosome via ZCCHC8, controlling telomeric R-loop levels and telomere stability.

    Evidence RIP, RBMX/ZCCHC8 Co-IP, TERRA level and R-loop measurement, and replication-stress assays

    PMID:37756323

    Open questions at the time
    • Direct handoff mechanism to exosome not reconstituted
    • Single-lab functional readouts
  17. 2024 Low

    Linked RBMX SUMOylation status to exosomal miRNA loading in diabetic kidney disease, extending RBMX RNA-binding roles to extracellular vesicle cargo.

    Evidence Co-IP, SUMOylation assays, RIP, confocal microscopy, and AAV-mediated Rbmx overexpression in mice

    PMID:39341454

    Open questions at the time
    • Complex multi-step mechanism with limited orthogonal validation
    • Direct RBMX-miRNA binding specificity not established
    • Disease-context specificity unclear
  18. 2024 Medium

    Showed the SOCS5 SH2 domain directly binds the RBMX RRM and co-activates the SREBP1 promoter to drive lipogenesis, providing a partner-based mechanism for RBMX transcriptional activity.

    Evidence Co-IP, GST-pulldown, SREBP1 promoter assay, and SH2/RRM domain mutation analysis

    PMID:38429411

    Open questions at the time
    • Relationship to SAFB1-dependent SREBP regulation unresolved
    • Single-lab functional context
  19. 2025 Medium

    Identified phosphorylation of RBMX at S189 as a regulatable mark influencing PLA2G7 alternative splicing and inflammatory output.

    Evidence multi-omics with site-specific dephosphorylation of RBMX S189 by mycobacterial PstP

    PMID:41675711

    Open questions at the time
    • Direct functional validation of S189 in splicing limited
    • Host kinase for S189 in normal physiology unknown
  20. 2025 Medium

    Demonstrated allele-specific RBMX binding to the DDIT4 3'UTR controlling DDIT4 protein levels and mTORC1 repression, implicating RBMX in 3'UTR-dependent translational/expression control.

    Evidence RNA-EMSA, RIP, smiFISH, RBMX depletion, CRISPR allele editing, and polysome profiling (preprint)

    Open questions at the time
    • Preprint; not peer-reviewed
    • Mechanism (stability vs translation) of allele-specific effect not fully resolved
  21. 2025 Medium

    Established functional redundancy between RBMX and its retrogene RBMXL1, explaining species-dependent phenotype severity through shared partners.

    Evidence Rbmx knockout mouse, human genetics, and Co-IP comparing RBMX/RBMXL1 partners with rescue (preprint)

    Open questions at the time
    • Preprint; not peer-reviewed
    • Extent of non-redundant RBMX functions undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RBMX integrates its parallel roles in co-transcriptional splicing, DNA-damage/replication-stress signaling, and centromeric cohesion into a unified molecular logic, and how its PTM repertoire (methylation, SUMOylation, phosphorylation) coordinates switching among them, remains unresolved.
  • No integrated structural model of domain usage across functions
  • Cross-talk between splicing and genome-maintenance activities untested
  • PTM hierarchy and timing not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 6 GO:0140110 transcription regulator activity 4 GO:0060090 molecular adaptor activity 3 GO:0003677 DNA binding 2
Localization
GO:0000228 nuclear chromosome 3 GO:0005634 nucleus 3
Pathway
R-HSA-8953854 Metabolism of RNA 4 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1640170 Cell Cycle 2 R-HSA-73894 DNA Repair 2
Partners
HNRNPA1HTRA2-BETA1SAFB1SOCS5SRSF1TOPBP1U2AF65ZCCHC8
Complex memberships
RBMX/SRSF1 splicing complexcentromere satellite I ncRNPcohesin (Scc1/Smc3/Wapl-associated)

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2012 RBMX accumulates at DNA double-strand break lesions through multiple protein domains in a PARP1-dependent manner and promotes homologous recombination by facilitating proper BRCA2 expression. Genome-wide siRNA screen, localization imaging at DNA lesions, RNAi knockdown with HR assay readout Nature cell biology High 22344029
2019 hnRNPG (RBMX) acts as an m6A reader protein that directly binds the phosphorylated C-terminal domain (CTD) of RNA Polymerase II via its RGG motifs in the low-complexity region, co-transcriptionally associates with RNAPII and nascent pre-mRNA, and regulates alternative splicing transcriptome-wide; m6A near splice sites modulates hnRNPG binding, which in turn influences RNAPII occupancy patterns and promotes exon inclusion. RNA binding assays, CLIP-seq, ChIP-seq, in vitro CTD binding assays, domain mutant analysis, transcriptome-wide splicing analysis Molecular cell High 31445886
2002 hnRNP-G (RBMX) promotes inclusion of SMN2 exon 7 via a direct protein-protein interaction with the SR-like splicing factor Htra2-beta1, not through non-specific RNA binding; deletion mutant analysis showed the specific protein-protein interaction mediates exon 7 inclusion. In vivo splicing assays, deletion mutagenesis of hnRNP-G, protein-protein interaction assays with Htra2-beta1 Human molecular genetics High 12165565
2012 RBMX maintains centromeric sister chromatid cohesion by associating with cohesin subunits Scc1 and Smc3, and with the cohesion regulator Wapl; RBMX depletion causes premature cohesin loss from centromeres before anaphase with delocalization of the shugoshin complex. RBMX is required for cohesion only in the presence of Wapl, suggesting RBMX acts as a Wapl inhibitor. RNAi depletion, co-immunoprecipitation with cohesin subunits, chromosome morphology analysis, epistasis with Wapl Cell reports High 22832223
2020 RBMX is an ssDNA-binding protein that, in response to replication stress, binds to ssDNA at adjacent but non-overlapping sites from RPA and recruits TopBP1, thereby activating ATR on repetitive DNA regions; this ssDNA-RBMX-TopBP1 pathway is independent of ssDNA-dsDNA junctions and the 9-1-1 complex. Super-resolution STORM imaging, ChIP-seq, RNAi depletion, in vitro ssDNA binding, replication stress assays, micronuclei and SCE measurement Cell death and differentiation High 32494026
2021 RBMX RGG/RG motif is methylated by PRMT5, which regulates assembly of RBMX with the SRSF1 splicing factor into higher-order complexes; depletion of RBMX or disruption of the RBMX/SRSF1 complex reduces SRSF1 binding to MDM4 pre-mRNA, leading to MDM4 exon 6 exclusion, lower MDM4 protein, and aberrant p53 pathway activation. PRMT5 methylation assay of RBMX RGG motif, co-immunoprecipitation of RBMX/SRSF1 complex, RIP for SRSF1-MDM4 pre-mRNA, splicing minigene/endogenous analysis, CRISPR-Cas9 isogenic Shashi-XLID hiPSCs, transcriptomic analysis Cell reports High 34260915
2021 RBMX and its retrogene RBMXL1 directly bind mRNAs and control nascent transcription of the CBX5 (HP1α) locus; forced CBX5 expression rescues cell growth and apoptosis defects caused by RBMX/L1 loss in myeloid leukemia cells. RIP for mRNA binding, chromatin accessibility assays, nascent RNA transcription analysis, rescue experiment with forced CBX5 expression, KD in murine and human AML cells Nature cancer High 34458856
2021 RBMX binds hnRNP A1 and competitively inhibits the combination of the RGG motif in hnRNP A1 with sequences flanking PKM exon 9, resulting in reduced PKM2 and elevated PKM1 levels, thereby attenuating glycolysis and tumor progression in bladder cancer. Co-immunoprecipitation of RBMX and hnRNP A1, PKM splicing analysis, RNAi and overexpression with functional assays in vitro and in vivo Oncogene Medium 33564070
2018 RBMX associates with satellite I noncoding RNA specifically during M phase and is a component of the centromere ncRNP complex; knockdown of RBMX or satellite I RNA causes premature sister chromatid separation, and satellite I RNA stabilizes RBMX and Sororin levels in the ncRNP complex. Purification of satellite I ncRNP complex by LC/MS, RNAi knockdown, cell cycle synchronization, immunofluorescence Genes to cells Medium 29383807
2010 hnRNP G (RBMX) contains at least three functionally distinct domains: an N-terminal RRM, a centrally positioned Nascent Transcripts Targeting Domain (NTD, residues 186–236) required for recruitment to active transcription units independently of RNA sequence specificity, and a C-terminal auxiliary RNA-binding domain (RBD, 58 residues) that recognizes an RNA hairpin motif. Deletion analysis in Xenopus oocytes, injection of domain mutants, RNA binding assays with characterized RNA probe Nucleus Medium 21327109
2011 hnRNPG (RBMX) inhibits splicing of tau exon 10 and interacts with SRp75 and hnRNPE2; SRp75 binds the proximal downstream intron of tau exon 10 at the FTDP-17 hotspot region, and hnRNPG forms a complex with SRp75 to regulate exon 10 splicing. Co-transfection splicing assays, co-immunoprecipitation, RNAi Gene Medium 21723381
2006 RBMX acts as a transcriptional regulator of the SREBP-1c gene promoter in mouse liver in response to high-fructose diet, as demonstrated by EMSA (anti-RBMX antibody displaces fructose-induced bands) and by the fact that overexpression or suppression of RBMX regulates SREBP-1c promoter activity in rat hepatoma cells. MALDI-TOF mass spectrometry identification, EMSA with anti-RBMX antibody, overexpression and siRNA suppression with SREBP-1c promoter assay FEBS letters Medium 17188681
2009 RBMX interacts with SAFB1 (scaffold attachment factor B1), and both proteins bind the upstream region of the Srebp-1c gene; SAFB1 is required for RBMX-induced Srebp-1c promoter activity, and the effect of SAFB1 overexpression on the Srebp-1c promoter is only observed in the presence of RBMX. Yeast two-hybrid screen, co-immunoprecipitation, chromatin immunoprecipitation (ChIP), RNAi, promoter activity assay BMB reports Medium 19403048
2008 RBMX associates with ARTS-1 (aminopeptidase regulator of TNFR1 shedding) by co-immunoprecipitation, and RNAi knockdown of RBMX reduces both constitutive release of TNFR1 exosome-like vesicles and IL-1β-mediated inducible proteolytic cleavage of TNFR1 ectodomains; conversely, RBMX overexpression increases both forms of TNFR1 release. Co-immunoprecipitation, RNAi knockdown, RBMX overexpression, TNFR1 release assays Biochemical and biophysical research communications Medium 18445477
2022 hnRNP G (RBMX) binds a purine-rich splicing enhancer sequence in HPV16 pre-mRNA and promotes splicing to splice site SA2709, enhancing E2 mRNA production; the splicing-enhancing function maps to amino acids 236–286 and involves interaction with splicing factor U2AF65. Additionally, DDR reduces sumoylation of hnRNP G and this enhances hnRNP G interactions with HPV16 E2 mRNAs and U2AF65. hnRNP G also promotes intron retention in the HPV16 E6 coding region to inhibit spliced E7 oncogene mRNA production. Mutational analysis of splicing enhancer, RNA binding assays, co-immunoprecipitation with U2AF65, domain deletion mapping, sumoylation assay, keratinocyte differentiation and DDR treatments Nucleic acids research Medium 35357488
2019 NORAD localizes predominantly to the cytoplasm (not nucleus) with or without DNA damage, and genetic rescue experiments showed PUM binding (not RBMX binding) is required for NORAD-mediated maintenance of genomic stability; RBMX binding to NORAD is dispensable for this function. RNA FISH, cellular fractionation, genetic rescue experiments with PUM-binding mutant and RBMX-binding mutant NORAD eLife High 31343408
2023 RBMX binds TERRA (telomeric repeat-containing RNA) and simultaneously binds the nuclear exosome targeting protein ZCCHC8; RBMX depletion elevates TERRA levels, enhances telomere R-loop formation, and slows TERRA degradation, indicating RBMX promotes TERRA degradation by facilitating its transport to the nuclear exosome. RNA immunoprecipitation, co-immunoprecipitation of RBMX and ZCCHC8, RBMX depletion with TERRA level measurement, R-loop analysis, replication stress assays PLoS genetics Medium 37756323
2015 RBMX interacts with Borna disease virus (BDV) nucleoprotein in the nucleus; knockdown of RBMX disrupts formation of viral nuclear inclusion bodies (vSPOTs) and reduces BDV transcription and replication. Co-immunoprecipitation of RBMX with BDV nucleoprotein, RNAi knockdown, fluorescence imaging of vSPOTs, BDV transcription/replication assay The Journal of general virology Medium 26333388
2007 RBMX (hnRNP-G) forms a complex with ZAP3, PP1, SAM68, CIA, and NF110/45 in the nucleus; the interaction of hnRNP-G with ZAP3 and SAM68 is lost upon digestion of endogenous nucleic acid, indicating these interactions are nucleic acid-dependent. Proteomic analysis (mass spectrometry) of ZAP3 complex, nucleic acid digestion experiment to test interaction dependency Biochimica et biophysica acta Low 17890166
2024 DeSUMOylation of RBMX in diabetic kidney disease alters exosomal miRNA content; RBMX binds miR-26a, miR-23c, and miR-874 within exosomes, and these miRNAs protect against mitochondrial damage by targeting CERS6 mRNA. Co-immunoprecipitation, SUMOylation assays, RNA immunoprecipitation, confocal microscopy, AAV-mediated Rbmx overexpression in mice Journal of advanced research Low 39341454
2024 The SOCS5 SH2 domain (with critical residues Y413 and D443) directly binds the RBMX RRM domain; SOCS5-RBMX co-stimulate the SREBP1 promoter to induce de novo lipogenesis, and SH2 domain mutations reverse this effect. Co-immunoprecipitation, GST-pulldown, SREBP1 promoter assay, domain mutation analysis NPJ precision oncology Medium 38429411
2025 Mycobacterial phosphatase PstP dephosphorylates RBMX at serine 189 (S189), which influences the alternative splicing of PLA2G7, resulting in increased levels of a PLA2G7 transcript containing exon 9 that potentiates inflammatory responses. Multi-omics (proteomics, phosphoproteomics, transcriptomics, interactomics), site-specific dephosphorylation analysis of RBMX S189 by PstP iMetaOmics Medium 41675711
2025 RBMX influences allele-dependent differences in DDIT4 protein expression at a 3'UTR SNP (rs1053639); RBMX binds DDIT4 3'UTR in an allele-specific manner (RNA-EMSA, RIP, smiFISH), and RBMX depletion reduces DDIT4 protein in TT clones to AA levels, modulating mTORC1 repression under ER stress. RNA-EMSA, RIP, smiFISH, RBMX depletion, CRISPR genome editing for allele comparison, polysome profiling bioRxivpreprint Medium
2025 RBMX and RBMXL1 share protein and RNA partners and act redundantly in brain development; RBMXL1 buffers the impact of RBMX deficiency in mice, explaining the discrepancy between severe human cortical phenotypes and mild mouse phenotypes upon Rbmx loss. Mouse Rbmx knockout model, human genetic analysis, protein/RNA partner co-immunoprecipitation comparing RBMX and RBMXL1, cellular rescue experiments bioRxivpreprint Medium

Source papers

Stage 0 corpus · 47 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nature cell biology 361 22344029
2019 Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG. Molecular cell 317 31445886
2002 hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1. Human molecular genetics 160 12165565
2006 Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer. Journal of cellular biochemistry 72 16552754
2012 RBMX: a regulator for maintenance and centromeric protection of sister chromatid cohesion. Cell reports 67 22832223
2021 RBMX suppresses tumorigenicity and progression of bladder cancer by interacting with the hnRNP A1 protein to regulate PKM alternative splicing. Oncogene 65 33564070
2004 The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis. International journal of andrology 60 15595951
2019 PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD. eLife 58 31343408
1998 Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. Genomics 49 9598316
2001 Expression and conservation of processed copies of the RBMX gene. Mammalian genome : official journal of the International Mammalian Genome Society 45 11420617
2018 RBMX family proteins connect the fields of nuclear RNA processing, disease and sex chromosome biology. The international journal of biochemistry & cell biology 41 30593955
2020 RBMX contributes to hepatocellular carcinoma progression and sorafenib resistance by specifically binding and stabilizing BLACAT1. American journal of cancer research 39 33294259
2005 RBMX gene is essential for brain development in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists 36 15895365
2019 A novel RBMX-TFE3 gene fusion in a highly aggressive pediatric renal perivascular epithelioid cell tumor. Genes, chromosomes & cancer 35 31408245
2011 An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia. Gene 35 21723381
2014 The RBMX gene as a candidate for the Shashi X-linked intellectual disability syndrome. Clinical genetics 31 25256757
2010 Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts. Nucleus (Austin, Tex.) 31 21327109
2007 The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G. Biochimica et biophysica acta 29 17890166
2021 Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia. Nature cancer 28 34458856
2008 Expression cloning in Xenopus identifies RNA-binding proteins as regulators of embryogenesis and Rbmx as necessary for neural and muscle development. Developmental dynamics : an official publication of the American Association of Anatomists 28 18521943
2008 An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release. Biochemical and biophysical research communications 25 18445477
2020 RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability. Cell death and differentiation 24 32494026
2006 RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet. FEBS letters 23 17188681
2012 Expression of RBMX after spinal cord injury in rats. Journal of molecular neuroscience : MN 22 23180094
2022 hnRNP G/RBMX enhances HPV16 E2 mRNA splicing through a novel splicing enhancer and inhibits production of spliced E7 oncogene mRNAs. Nucleic acids research 19 35357488
2018 RBMX is a component of the centromere noncoding RNP complex involved in cohesion regulation. Genes to cells : devoted to molecular & cellular mechanisms 17 29383807
2021 Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects. Cell reports 16 34260915
2009 SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene. BMB reports 14 19403048
2024 Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors PRPF8 and RBMX as novel candidate actionable targets. Molecular oncology 11 38790138
2002 Autoimmune antibodies to hnRNPG protein in dogs with systemic lupus erythematosus: epitope mapping of the antigen. Journal of autoimmunity 11 12126635
2023 Gustavson syndrome is caused by an in-frame deletion in RBMX associated with potentially disturbed SH3 domain interactions. European journal of human genetics : EJHG 10 37277488
2023 RBMX involves in telomere stability maintenance by regulating TERRA expression. PLoS genetics 10 37756323
2024 SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis. NPJ precision oncology 9 38429411
2024 DeSUMOylation of RBMX regulates exosomal sorting of cargo to promote renal tubulointerstitial fibrosis in diabetic kidney disease. Journal of advanced research 9 39341454
2015 X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virus nuclear viral factories. The Journal of general virology 9 26333388
2014 Expression of RBMX in the light-induced damage of rat retina in vivo. Cellular and molecular neurobiology 8 25407628
2006 Associations of homologous RNA-binding motif gene on the X chromosome (RBMX) and its like sequence on chromosome 9 (RBMXL9) with non-obstructive azoospermia. Asian journal of andrology 8 16491274
2022 Identification of RBMX as a splicing regulator in Parkinsonian mimetic induced alternative splicing of α-synuclein. Biochimica et biophysica acta. Gene regulatory mechanisms 7 35577270
2025 Cancer-Derived Exosomal LINC01615 Induces M2 Polarization of Tumor-Associated Macrophages via RBMX-EZH2 Axis to Promote Colorectal Cancer Progression. International journal of nanomedicine 6 40529536
2004 The X-chromosome RBMX Gene is Expressed in Mammary Carcinoma. Cancer genomics & proteomics 3 31394616
2025 Dynamic Interplay Between miR-133a and RBMX During Dengue Virus Infection. Journal of medical virology 1 40772600
2025 The RNA-Binding Protein RBMX Mediates the Immunosuppressive Microenvironment of Osteosarcoma by Regulating CD8+T Cells. Cancers 1 40941025
2025 Mycobacterial PstP impairs host RNA alternative splicing by dephosphorylation of spliceosome RBMX at S189. iMetaOmics 1 41675711
2026 RBMX Transcriptionally Repressed by EZH2-Associated H3K27me3 Modification Attenuates Pyroptosis in Renal Ischemia/Reperfusion Injury via Regulating SIRT3/NLRP3 Inflammasome Activation. The Kaohsiung journal of medical sciences 0 41769733
2026 CDH4/UBA1/RBMX axis promotes polycystic ovary syndrome progression through YAP1 activation. Cellular & molecular biology letters 0 41882537
2026 ALKBH5/IGF2BP1-mediated m6A demethylation of TRIM37 promotes pancreatic cancer tumorigenesis and glycolysis by mediating RBMX degradation. Cell biology and toxicology 0 41922631
2024 [RBMX overexpression inhibits proliferation, migration, invasion and glycolysis of human bladder cancer cells by downregulating PKM2]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 0 38293971

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