Affinage

TRA2B

Transformer-2 protein homolog beta · UniProt P62995

Round 2 corrected
Length
288 aa
Mass
33.7 kDa
Annotated
2026-04-28
55 papers in source corpus 19 papers cited in narrative 19 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TRA2B (Tra2β) is an SR-like RNA-binding protein that governs alternative splicing by recognizing AG/GAA-rich exonic splicing enhancers and recruiting additional SR proteins such as SRp30c to promote exon inclusion (PMID:10931943, PMID:11875052). Its protein concentration is homeostatically controlled by a poison-exon/nonsense-mediated decay autoregulatory loop whose disruption causes meiotic catastrophe and azoospermia, while homozygous loss results in early embryonic lethality and cortex-specific deletion triggers neural progenitor apoptosis (PMID:39748121, PMID:20190275, PMID:23818142). TRA2B directs tissue-specific splicing programs with broad physiological impact—hepatic LPIN1 isoform balance controlling lipogenesis, PKCδ splicing during adipogenesis, Wnt11b intron retention in somitogenesis, and AR-V7 generation in prostate cancer—and germline loss-of-function variants that shift isoform ratios toward a dominant-negative Tra2β-3 form cause a neurodevelopmental syndrome linked to defective CHEK1 exon 3 inclusion (PMID:21803291, PMID:25261467, PMID:25620705, PMID:41919500, PMID:36549593).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1997 Medium

    Establishing TRA2B as a nuclear SR-like protein that localizes to speckles and interacts with classical SR proteins answered the fundamental question of where and how it fits within the splicing regulatory network.

    Evidence Yeast two-hybrid with SC35 bait, immunofluorescence colocalization, subcellular fractionation in human cells

    PMID:9212162

    Open questions at the time
    • Interaction with SR proteins relied on yeast two-hybrid without endogenous co-IP validation
    • RNA targets unknown at this stage
    • Functional consequence of speckle localization not tested
  2. 2000 High

    Demonstrating that TRA2B directly binds an AG-rich exonic splicing enhancer in SMN exon 7 to promote its inclusion resolved the mechanism by which this SR-like protein activates a specific splice event, establishing a paradigm for its RNA-binding specificity.

    Evidence Minigene splicing assay and RNA binding assay in human/mouse cells with SMN2 constructs

    PMID:10931943

    Open questions at the time
    • Structural basis of AG-rich enhancer recognition not resolved
    • Whether TRA2B is sufficient or requires co-factors for SMN exon 7 inclusion was unclear
  3. 2002 High

    Showing that SRp30c requires a physical interaction with TRA2B to access the SMN exon 7 enhancer established the cooperative recruitment model whereby TRA2B bridges RNA and additional splicing factors.

    Evidence Reciprocal co-immunoprecipitation and RNA pull-down combined with minigene splicing assay

    PMID:11875052

    Open questions at the time
    • Full composition of the TRA2B-nucleated enhancer complex on SMN exon 7 not defined
    • Whether this recruitment model generalizes to all TRA2B targets was untested
  4. 2009 Medium

    Discovery that oxidative stress triggers TRA2B phosphorylation and nuclear-to-cytoplasmic translocation, altering CD44 splicing and cell growth, revealed that TRA2B activity is dynamically regulated by signaling inputs.

    Evidence Arsenite treatment, immunofluorescence, phospho-Western blot, siRNA/overexpression with CD44 minigene in human cells

    PMID:19439532

    Open questions at the time
    • Kinase(s) responsible for stress-induced phosphorylation not identified
    • Whether cytoplasmic TRA2B has non-splicing functions remains unknown
  5. 2010 High

    Demonstrating that homozygous Tra2b knockout causes embryonic lethality at E7.5 established the gene as essential for mammalian development and showed its role is not limited to SMN exon 7 splicing.

    Evidence Conditional Cre/loxP knockout mice, embryo phenotyping, RT-PCR of Smn isoforms in MEFs

    PMID:20190275

    Open questions at the time
    • Critical embryonic splicing targets causing lethality not identified
    • Functional redundancy with TRA2A not systematically tested
  6. 2011 High

    Identifying LPIN1 as a direct splicing target placed TRA2B upstream of hepatic lipogenesis, showing its role extends to metabolic regulation: reduced TRA2B favors the lipogenic LPIN1β isoform, and epistasis experiments confirmed a linear pathway.

    Evidence siRNA in hepatocytes, Sfrs10 heterozygous mice, VLDL secretion assay, LPIN1β-specific rescue

    PMID:21803291

    Open questions at the time
    • Whether TRA2B directly binds LPIN1 pre-mRNA at the regulated exon was not shown by CLIP
    • Other metabolic splicing targets of TRA2B not catalogued
  7. 2014 High

    Cortex-specific and neuron-specific Tra2b knockouts revealed that TRA2B is required for neural progenitor survival, with its loss causing massive apoptosis linked to p21 upregulation, and identified endogenous brain splicing targets (Tubulin δ1, Shugoshin-like 2).

    Evidence Nestin-Cre and cortex-specific Cre conditional KO, exon arrays, TUNEL, immunohistochemistry, p21 Western blot

    PMID:23818142 PMID:24586484

    Open questions at the time
    • Whether p21 upregulation is a direct or indirect consequence of mis-splicing not resolved
    • Specific splicing events driving apoptosis not individually validated by rescue
  8. 2014 High

    Direct RNA-immunoprecipitation and binding-site mutagenesis on PKCδ exon 9 established that TRA2B directly promotes PKCδI inclusion required for preadipocyte mitotic clonal expansion, broadening its target repertoire to adipogenesis.

    Evidence RNA-IP, site-directed mutagenesis of TRA2B binding sites, minigene, siRNA, 3T3-L1 proliferation assay

    PMID:25261467

    Open questions at the time
    • Genome-wide binding map in adipocytes not available
    • Contribution of TRA2A to this event not assessed
  9. 2015 High

    Tra2b knockdown in Xenopus caused somitogenesis failure recapitulated by a single intron-retaining Wnt11b isoform, providing the first in vivo demonstration that a single TRA2B-regulated splice event is sufficient to account for a developmental phenotype.

    Evidence Morpholino knockdown, RNA-seq of 142 splice changes, dominant-negative intron-retaining Wnt11b construct in Xenopus embryos

    PMID:25620705

    Open questions at the time
    • Whether mammalian somitogenesis similarly depends on TRA2B-Wnt11b axis is untested
    • Mechanism by which TRA2B suppresses intron retention in Wnt11b not detailed
  10. 2019 High

    Identification of a G-quadruplex in the TRA2B promoter and its regulation by hnRNPA1 revealed a transcriptional control layer: G4 formation suppresses TRA2B transcription, and hnRNPA1 binding relieves this repression.

    Evidence Circular dichroism, EMSA, ChIP, promoter reporter assay, siRNA knockdown of hnRNPA1/hnRNPU

    PMID:31311954

    Open questions at the time
    • Physiological contexts in which G4-mediated regulation is activated not defined
    • Whether G4 dynamics contribute to tissue-specific TRA2B expression unknown
  11. 2022 High

    Germline loss-of-function variants in TRA2B were shown to shift isoform balance toward the dominant-negative Tra2β-3 form, which interferes with CHEK1 exon 3 inclusion, establishing the molecular basis of a neurodevelopmental syndrome.

    Evidence Patient RNA-seq, Western blot of isoform ratios, HEK-293 transfection with isoform-specific GFP constructs and CHEK1 minigene

    PMID:36549593

    Open questions at the time
    • Full spectrum of mis-spliced targets in patient neurons not catalogued
    • Whether the neurodevelopmental phenotype is primarily driven by CHEK1 mis-splicing or broader splicing dysregulation is unclear
  12. 2025 High

    Disruption of the ultra-conserved poison exon that mediates TRA2B autoregulation via NMD caused azoospermia through meiotic prophase apoptosis driven by toxic Tra2β accumulation, demonstrating that precise dosage control is essential for spermatogenesis.

    Evidence CRISPR-mediated poison exon deletion in mice, histology, RNA-seq, Tra2β protein quantification

    PMID:39748121

    Open questions at the time
    • Meiotic splicing targets dysregulated by Tra2β overaccumulation not individually validated
    • Whether poison-exon disruption affects other tissues at subclinical levels unknown
  13. 2026 Medium

    Identification of TRA2B as a selective mRNA interactor promoting AR-V7 splice variant synthesis in prostate cancer connected its splicing activity to castration-resistant prostate cancer growth.

    Evidence CasRx-based mRNA interactor screen, siRNA knockdown, cell growth assay, CRPC transcriptomic correlation

    PMID:41919500

    Open questions at the time
    • Direct RNA binding site on AR pre-mRNA not mapped
    • In vivo validation in prostate cancer models lacking
    • Therapeutic window for TRA2B attenuation not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • A genome-wide direct binding map (CLIP/eCLIP) across multiple tissues, a structural understanding of TRA2B enhancer recognition, and systematic delineation of functional redundancy with TRA2A remain major unresolved questions.
  • No published CLIP-seq binding atlas for TRA2B across tissues
  • No crystal or cryo-EM structure of TRA2B-RNA complex
  • Systematic TRA2A/TRA2B double-knockout studies not reported

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140098 catalytic activity, acting on RNA 7 GO:0003723 RNA binding 4 GO:0098772 molecular function regulator activity 2
Localization
GO:0005634 nucleus 3 GO:0005654 nucleoplasm 3 GO:0005829 cytosol 1
Pathway
R-HSA-8953854 Metabolism of RNA 9 R-HSA-1266738 Developmental Biology 4 R-HSA-1643685 Disease 2 R-HSA-74160 Gene expression (Transcription) 1
Partners
HNRNPA1ILDR1ILDR2SC35SRP30CSRSF1SRSF10TRA2A

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 Htra2-beta1 (TRA2B) promotes inclusion of SMN exon 7 by binding an AG-rich exonic splicing enhancer in SMN exon 7, stimulating full-length SMN2 expression in human and mouse cells carrying an SMN2 minigene. Minigene splicing assay in human/mouse cells, RNA binding assay, transient expression Proceedings of the National Academy of Sciences of the United States of America High 10931943
1997 TRA2B (htra2-beta1) is a nuclear SR-like protein that colocalizes with SC35 in nuclear speckles and interacts with multiple SR proteins; a second isoform, htra2-beta2, generated by alternative splicing lacks the SR domain. Yeast two-hybrid screen using SC35 as bait, immunofluorescence colocalization, subcellular fractionation DNA and cell biology Medium 9212162
1998 The TRA2B isoform htra2-beta3 lacks the first SR domain, is expressed predominantly in brain, liver, testis and kidney, localizes to the nucleus, and interacts with a subset of SR proteins, paralleling a variant found in the Drosophila male germline. RT-PCR, yeast two-hybrid, immunofluorescence, radiation hybrid mapping Genomics Medium 9790768
2002 SRp30c stimulates SMN exon 7 inclusion through the same AG-rich enhancer as TRA2B, but does so indirectly via a direct protein–protein interaction with TRA2B; in the absence of the TRA2B binding site on the enhancer, SRp30c fails to associate with SMN exon 7. Minigene splicing assay, co-immunoprecipitation, RNA pull-down Human molecular genetics High 11875052
2009 Oxidative stress (arsenite) induces translocation of TRA2B from the nucleus to the cytoplasm associated with enhanced phosphorylation, and TRA2B regulates alternative splicing of CD44 (combinatorial inclusion of variable exons) and controls cell growth. Immunofluorescence, Western blot (phosphorylation), siRNA knockdown, overexpression, minigene/RT-PCR, cell growth assay American journal of physiology. Cell physiology Medium 19439532
2010 Homozygous deletion of Sfrs10 (TRA2B) in mice causes early embryonic lethality around E7.5, demonstrating an essential role during mouse embryogenesis; motor-neuron-specific deletion does not produce an SMA phenotype, and Sfrs10 deletion in MEFs increases SmnΔ7 levels modestly but has no impact on full-length Smn splicing. Conditional knockout (Cre/loxP), embryo phenotyping, RT-PCR, MEF-derived cells with recombinant Cre Human molecular genetics High 20190275
2011 SFRS10 (TRA2B) regulates alternative splicing of LPIN1 pre-mRNA; reduced SFRS10 favors the lipogenic LPIN1β isoform, and LPIN1β-specific siRNA abolishes the lipogenic effects of decreased SFRS10, placing TRA2B upstream of LPIN1β in hepatic lipogenesis. siRNA knockdown, Sfrs10 heterozygous mice, hepatic gene expression analysis, VLDL secretion assay, epistasis by rescue experiment Cell metabolism High 21803291
2012 Digitoxin depletes TRA2B (and SRSF3) from cells; re-expression of TRA2B after digitoxin treatment restores normal splicing of TRA2B-target exons, demonstrating that TRA2B depletion directly mediates the digitoxin-induced alternative splicing changes. Transcriptome-wide splicing analysis (RNA-seq), rescue by re-expression, motif enrichment analysis RNA (New York, N.Y.) High 22456266
2014 TRA2B is required for survival of neural progenitor cells; cortex-specific Tra2b knockout mice display apoptosis of neural progenitor cells and disorganization of the cortical plate. Cortex-specific conditional knockout (Cre/loxP), immunohistochemistry, TUNEL apoptosis assay The Journal of comparative neurology High 23818142
2014 Neuronal-specific deletion of Tra2b causes massive apoptosis in ventricular layers of the cortex and perinatal lethality; Tra2b loss leads to increased p21 (CDKN1A) expression, which is functionally linked to neuronal precursor cell death. In vivo exon array analysis identifies Tubulinδ1 and Shugoshin-like2 as splicing targets of Tra2b. Nestin-Cre conditional knockout, exon arrays, immunohistochemistry, TUNEL, siRNA in NSC34 cells, Western blot PloS one High 24586484
2014 TRA2B promotes inclusion of PKCδ exon 9 in the PKCδI splice variant during 3T3L1 preadipocyte cell cycle; mutagenesis of TRA2B binding sites on exon 9 and RNA-immunoprecipitation confirmed direct binding is required for this splicing event, and PKCδI is required for mitotic clonal expansion of preadipocytes. Minigene splicing assay, mutagenesis, RNA-immunoprecipitation, siRNA knockdown, cell proliferation assay The Journal of biological chemistry High 25261467
2015 Tra2b knockdown in Xenopus causes defective somitogenesis and other developmental defects; RNA-seq identified 142 Tra2b-dependent splice changes (mostly intron retention and exon skipping). A novel Wnt11b isoform retaining the last intron (Wnt11b-short) acts as a dominant-negative ligand and its retention recapitulates the failure to form somites, placing Tra2b upstream of Wnt11b isoform balance in somitogenesis. Morpholino knockdown, RNA-seq, minigene intron retention induction, dominant-negative rescue experiment in Xenopus Cell reports High 25620705
2016 A TRA2B-DNAH5 gene fusion in lung squamous cell carcinoma promotes malignant progression through a SIRT6-ERK1/2-MMP1 signaling axis; ERK1/2 inhibition with selumetinib efficiently inhibits growth of lung SCC expressing this fusion. Exon array analysis, molecular cloning of fusion, functional studies (pathway analysis, ERK1/2 inhibition), patient sample analysis Cell research Medium 27670699
2017 ILDR1 and ILDR2 (angulin proteins) physically bind to TRA2B (as well as TRA2A and SRSF1) and translocate to the nucleus when TRA2B is present; knockdown of ILDR1/ILDR2 alters alternative splicing of TUBD1 and IQCB1, targets regulated by TRA2B. Co-immunoprecipitation, nuclear translocation assay, siRNA knockdown, minigene splicing assay Scientific reports Medium 28785060
2019 hnRNPA1 interacts with a G-quadruplex (G4) structure in the TRA2B promoter and stimulates TRA2B transcription; G4 formation suppresses TRA2B transcription, whereas hnRNPA1 binding to G4 relieves this repression. hnRNPU also positively regulates TRA2B promoter activity but does not interact with G4. Circular dichroism, EMSA, ChIP, minigene assay, siRNA knockdown, promoter reporter assay Scientific reports High 31311954
2022 Germline loss-of-function variants clustered in the 5′ region of TRA2B (upstream of an alternative translation start site) decrease canonical Tra2β-1 isoform expression while increasing the shorter Tra2β-3 isoform (lacking the N-terminal RS1 domain); increased Tra2β-3 interferes with CHEK1 exon 3 inclusion, revealing a dominant-negative mechanism underlying the associated neurodevelopmental syndrome. RNA sequencing of patient cells, Western blot of isoforms, HEK-293 transfection with Tra2β1-GFP, Tra2β3-GFP, and CHEK1 exon 3 minigene Genetics in medicine : official journal of the American College of Medical Genetics High 36549593
2023 Two TRA2B isoforms play distinct roles in myogenic differentiation: they differentially regulate alternative splicing of TGFBR2, thereby triggering canonical TGF-β signalling cascades differently. Iso-seq, single-cell RNA-seq, isoform-specific functional analysis in myogenesis model Cell proliferation Medium 37705195
2025 An ultra-conserved poison exon (PE) in the Tra2b gene controls Tra2β protein concentration via nonsense-mediated decay; disruption of this PE in mice causes azoospermia due to catastrophic apoptotic cell death during meiotic prophase, associated with elevated Tra2β protein levels driving aberrant hyper-responsive splicing patterns. Mitotically active germ cells are spared despite requiring Tra2b function, indicating the PE prevents toxic Tra2β accumulation incompatible with meiotic prophase. Mouse genetics (PE deletion by CRISPR/homologous recombination), histology, RNA-seq, protein expression analysis The EMBO journal High 39748121
2026 TRA2B promotes synthesis of the constitutively active androgen receptor splice variant AR-V7 in prostate cancer cells at the expense of full-length AR isoforms; TRA2B and its ortholog TRA2A were identified as selective protein interactors of AR-V7 mRNA, and attenuation of TRA2-mediated splicing diminishes prostate cancer cell growth. RNA-targeting CasRx approach for mRNA interactor identification, siRNA knockdown, cell growth assay, correlation with CRPC transcriptomic data The Journal of clinical investigation Medium 41919500

Source papers

Stage 0 corpus · 55 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (New York, N.Y.) 3312 19608861
2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2861 17081983
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2006 A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nature biotechnology 1336 16964243
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
1996 The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics 1095 8617505
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2008 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nature genetics 1049 19079260
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Molecular cell 973 22681889
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
2017 Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.) 533 28302793
2011 A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer cell 460 22094256
2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature 445 25231870
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2010 Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (New York, N.Y.) 421 20360068
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2010 Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature genetics 392 21102462
2004 Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Current biology : CB 386 15324660
2000 Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2). Proceedings of the National Academy of Sciences of the United States of America 274 10931943
2011 Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell metabolism 135 21803291
2002 SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1. Human molecular genetics 121 11875052
2020 Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B. Cancer letters 109 32682951
1998 Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform. Genomics 77 9790768
1997 Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing. DNA and cell biology 72 9212162
2012 The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B. RNA (New York, N.Y.) 55 22456266
2010 Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing. Human molecular genetics 52 20190275
2019 HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells. Scientific reports 42 31311954
2009 Oxidative stress-induced alternative splicing of transformer 2beta (SFRS10) and CD44 pre-mRNAs in gastric epithelial cells. American journal of physiology. Cell physiology 37 19439532
2014 Splicing factor TRA2B is required for neural progenitor survival. The Journal of comparative neurology 35 23818142
2015 The alternative splicing regulator Tra2b is required for somitogenesis and regulates splicing of an inhibitory Wnt11b isoform. Cell reports 31 25620705
2016 Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma. Cell research 27 27670699
2014 Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain. PloS one 27 24586484
2014 Transformer 2β (Tra2β/SFRS10) positively regulates the progression of NSCLC via promoting cell proliferation. Journal of molecular histology 20 24952301
2017 Angulin proteins ILDR1 and ILDR2 regulate alternative pre-mRNA splicing through binding to splicing factors TRA2A, TRA2B, or SRSF1. Scientific reports 17 28785060
2019 Expression of TRA2B in endometrial carcinoma and its regulatory roles in endometrial carcinoma cells. Oncology letters 11 31452736
2014 Transformer 2β homolog (Drosophila) (TRA2B) regulates protein kinase C δI (PKCδI) splice variant expression during 3T3L1 preadipocyte cell cycle. The Journal of biological chemistry 10 25261467
2023 Bulk and single-cell alternative splicing analyses reveal roles of TRA2B in myogenic differentiation. Cell proliferation 9 37705195
2013 Expression analysis of an evolutionarily conserved alternative splicing factor, Sfrs10, in age-related macular degeneration. PloS one 8 24098751
2022 Clustered variants in the 5' coding region of TRA2B cause a distinctive neurodevelopmental syndrome. Genetics in medicine : official journal of the American College of Medical Genetics 6 36549593
2025 An ultra-conserved poison exon in the Tra2b gene encoding a splicing activator is essential for male fertility and meiotic cell division. The EMBO journal 5 39748121
2013 The expression analysis of Sfrs10 and Celf4 during mouse retinal development. Gene expression patterns : GEP 3 23932931
2023 TRA2B Gene Splice Variant Linked to Seizures and Neurodevelopmental Delay: A Second Case Study. International journal of molecular sciences 1 37958557
2026 Splicing factor TRA2B enhances synthesis of androgen receptor variant AR-V7 in prostate cancer cells. The Journal of clinical investigation 0 41919500