Affinage

SNRPC

U1 small nuclear ribonucleoprotein C · UniProt P09234

Length
159 aa
Mass
17.4 kDa
Annotated
2026-06-10
45 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SNRPC (U1-C) is an integral, splice-site-recognition subunit of the U1 snRNP that fine-tunes 5' splice site selection during the earliest steps of pre-mRNA splicing (PMID:8972845, PMID:25555158). Its N-terminal CC-HH zinc finger is necessary and sufficient for incorporation into the particle, but U1-C does not bind naked U1 snRNA; instead it is recruited through the Sm core proteins (including a direct contact with Sm B'/B) and the N-terminal domain of U1-70K (PMID:1826349, PMID:8076607, PMID:19325628). Once incorporated, U1-C contacts the RNA duplex formed between the pre-mRNA 5' splice site and U1 snRNA, stabilizing it through hydrogen bonds and electrostatic contacts to the RNA backbone without making base-specific contacts, so that base pairing with U1 snRNA dictates selection while U1-C tunes relative affinity for imperfect 5' splice sites (PMID:25555158, PMID:29794219). This stabilizing activity is required to form and stabilize the early (E) spliceosomal complex and is directly counteracted by the DEAD-box ATPase Prp28, which displaces U1 snRNP from the 5'SS to permit spliceosome progression; mutations that weaken the U1-C/5'SS interface bypass the otherwise essential requirement for Prp28 (PMID:8972845, PMID:11172727, PMID:24497193). U1-C associates reversibly and dynamically with U1 snRNP, and this reversible engagement is the mechanistic basis through which the small-molecule modulator branaplam stabilizes long-lived U1 snRNP/5'SS complexes at bulged 5' splice sites (PMID:19784376, PMID:39389991). U1-C also binds the splicing regulator TIA-1 to recruit U1 snRNP to weak 5' splice sites and contributes to RNA Pol II-controlled transcription of oncogenes by maintaining U1 snRNP stability (PMID:12486009, PMID:37057875).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1991 High

    Established the structural determinant by which U1-C joins the U1 snRNP, defining its zinc finger as the assembly module rather than an RNA-binding domain.

    Evidence Deletion and zinc-coordinating-residue mutagenesis with chemical modification and IP binding assays

    PMID:1826349

    Open questions at the time
    • Did not identify the specific U1 snRNP protein(s) mediating recruitment
    • No structural model of the zinc finger fold
  2. 1994 High

    Resolved how U1-C is recruited, showing it depends on Sm proteins and the U1-70K N-terminal domain rather than direct snRNA binding.

    Evidence IP of in vitro translated proteins with core snRNPs, U1-70K deletion mapping, chemical crosslinking of purified U1 snRNP

    PMID:8076607

    Open questions at the time
    • Stoichiometry and spatial arrangement of contacts not defined
    • Did not address function at the 5'SS
  3. 1996 High

    Demonstrated a functional requirement for U1-C in early spliceosome assembly, distinguishing it from U1-A.

    Evidence In vitro reconstitution of U1 snRNP from purified components and E-complex complementation in U1-depleted HeLa extracts

    PMID:8972845

    Open questions at the time
    • Did not show how U1-C contacts the 5'SS RNA
    • Mechanism of stimulation at atomic level unresolved
  4. 1996 Medium

    Showed U1-C directly contacts 5'SS RNA and that initial recognition does not require base pairing, implicating protein contacts in early 5'SS engagement.

    Evidence UV crosslinking and binding kinetics of purified U1 snRNP with 5'SS oligonucleotides, RNase H cleavage

    PMID:8798632

    Open questions at the time
    • Single lab, crosslinking does not localize the contact at residue level
    • Relative contributions of U1-C versus other proteins not separated
  5. 2001 High

    Placed U1-C in the dynamic splicing pathway, showing it stabilizes the U1/5'SS duplex and that Prp28 acts to counteract this stabilization.

    Evidence Genetic epistasis and suppressor mutations in yeast U1-C, growth assays

    PMID:11172727

    Open questions at the time
    • Structural basis of the L13 contact inferred genetically, not visualized
    • Mechanism of Prp28-driven displacement not detailed
  6. 2002 High

    Identified TIA-1 as a direct U1-C partner that recruits U1 snRNP to weak 5' splice sites, extending U1-C function into regulated splice-site selection.

    Evidence Co-precipitation with recombinant protein fragments, RRM deletion analysis, splicing assays

    PMID:12486009

    Open questions at the time
    • Interface residues on U1-C not mapped
    • In vivo target sites of TIA-1/U1-C cooperation not enumerated
  7. 2009 High

    Provided the first structural placement of U1-C within the intact particle, showing the U1-70K N-terminus wraps the Sm core to contact U1-C.

    Evidence X-ray crystallography at 5.5 Å with site-specific labelling

    PMID:19325628

    Open questions at the time
    • Resolution insufficient for atomic contacts
    • 5'SS RNA not present in the structure
  8. 2009 Medium

    Revealed that U1-C is a dynamically exchanging subunit whose C-terminal tail and U1-70K isoform/phosphorylation state control its association.

    Evidence Native mass spectrometry of purified U1 snRNP comparing native and recombinant complexes

    PMID:19784376

    Open questions at the time
    • Mechanistic inference from composition data, not direct kinetics
    • Functional consequence of dynamic exchange not tested
  9. 2011 Medium

    Structurally rationalized the TIA-1/U1-C interaction by showing TIA-1 folds into a 'V' that juxtaposes its RRM1 and Q-domain to contact U1-C.

    Evidence ITC, SAXS, and RNA binding assays with TIA-1 deletion variants

    PMID:22154808

    Open questions at the time
    • No co-structure of the TIA-1/U1-C complex
    • U1-C residues engaged not defined
  10. 2014 High

    Mapped specific U1-C surface residues that fortify the U1/5'SS complex through contacts with the Sm core, linking the interface to Prp28 bypass.

    Evidence Alanine-scanning mutagenesis and yeast genetic interaction screens in Yhc1

    PMID:24497193

    Open questions at the time
    • Yeast ortholog data; human residue equivalence inferred
    • Direct biochemical affinity changes not quantified
  11. 2015 High

    Defined at atomic resolution that U1-C stabilizes the U1 snRNA/5'SS duplex via backbone contacts without base-specific recognition, settling how it tunes splice-site affinity.

    Evidence Atomic-resolution X-ray crystallography with RNA binding assays; extended by yeast interface mutagenesis

    PMID:25555158 PMID:25897024

    Open questions at the time
    • Engineered sub-structures rather than full native particle
    • Dynamics of duplex stabilization not captured in static structure
  12. 2018 High

    Visualized U1-C's role within native spliceosomes, showing it recognizes the 5'SS/U1 duplex in pre-B and is released as U1 snRNP dissociates in the B complex.

    Evidence Cryo-EM of yeast pre-B and B spliceosomal complexes at 3.3–4.6 Å

    PMID:29794219

    Open questions at the time
    • Yeast complexes; human spliceosome transitions inferred
    • Does not resolve the Prp28-catalyzed displacement intermediate
  13. 2022 Low

    Linked SNRPC dosage to alternative polyadenylation site usage at the transcriptome level.

    Evidence siRNA knockdown, overexpression, and transcriptome-level APA analysis

    PMID:36073763

    Open questions at the time
    • SNRPC-specific mechanism in APA not individually resolved
    • Effect inferred from transcriptome readout, not direct binding
    • Single lab
  14. 2023 Medium

    Connected U1 snRNP stability via SNRPC to RNA Pol II-controlled oncogene transcription and tumor progression.

    Evidence In vivo CRISPR screen, CRISPR knockout, RNA Pol II ChIP, and in vivo TNBC tumor models

    PMID:37057875

    Open questions at the time
    • Mechanistic link between U1 snRNP stability and Pol II enrichment not fully resolved
    • Single lab
    • Generality beyond TNBC oncogenes untested
  15. 2024 High

    Established the kinetic mechanism by which U1-C's reversible binding enables small-molecule modulation, with branaplam binding only after the complex engages a bulged 5'SS.

    Evidence Colocalization single-molecule spectroscopy (CoSMoS) and ensemble kinetic measurements

    PMID:39389991

    Open questions at the time
    • Structural basis of branaplam binding to the U1-C/5'SS complex not solved
    • Generality across other splice-site sequences not exhaustively mapped

Open questions

Synthesis pass · forward-looking unresolved questions
  • How U1-C's dynamic exchange and post-translational modification are regulated in vivo, and how its U1 snRNP-stabilizing role couples to transcription and 3'-end processing, remain unresolved.
  • No mechanistic account of SNRPC-specific contribution to APA
  • Signaling/PTM control of U1-C exchange not defined in cells

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0003723 RNA binding 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005634 nucleus 1
Pathway
R-HSA-8953854 Metabolism of RNA 3 R-HSA-74160 Gene expression (Transcription) 1
Partners
SNRNP70SNRPBSNRPD3TIA1
Complex memberships
U1 snRNPpre-B spliceosomespliceosomal E complex

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1991 The N-terminal zinc finger-like (CC-HH type) structure of U1-C is essential for binding to U1 snRNP particles. Deletion analysis showed the N-terminal 45 amino acids are sufficient for binding; modification of cysteine residues with N-ethylmaleimide or single point mutations of the cysteines and histidines abolished binding. U1-C does not bind naked U1 snRNA alone, and requires both U1 snRNA and one or more U1 snRNP proteins for association. Deletion mutagenesis, site-directed mutagenesis of zinc-coordinating residues, chemical modification (N-ethylmaleimide), immunoprecipitation binding assays Nucleic acids research High 1826349
1994 U1-C does not bind naked U1 snRNA directly but requires the common Sm proteins and the N-terminal domain of U1-70K for its association with U1 snRNP. The N-terminal domain of U1-70K is necessary and sufficient for recruiting U1-C to core U1 snRNP. Chemical crosslinking of purified U1 snRNPs detected a direct crosslink between U1-C and the Sm B'/B protein. Immunoprecipitation of complexes formed with in vitro translated proteins and core snRNPs, binding studies with U1-70K deletion mutants, chemical crosslinking of purified U1 snRNPs The EMBO journal High 8076607
1996 The U1-C protein (but not U1-A) is required for the formation and/or stabilization of early (E) spliceosomal complexes in mammalian splicing. Reconstituted U1 snRNPs lacking U1-C failed to complement E complex formation, and the N-terminal domain of U1-C was necessary and sufficient for this stimulatory activity. In vitro reconstitution of U1 snRNPs from purified components, splicing complementation assays in U1-depleted HeLa extracts, E complex formation assays with recombinant U1-C mutants Nucleic acids research High 8972845
1996 U1-C protein makes direct contacts with the 5' splice site RNA oligonucleotide: UV crosslinking showed U1-C becomes crosslinked to the 5'SS RNA upon UV irradiation of purified U1 snRNP/5'SS RNA complexes. Kinetic studies also showed that the 5'SS–U1 snRNP interaction does not require base pairing for initial association (RNase H cleavage of U1 snRNA 5' end did not affect association rate) but base pairing is required for stability, indicating U1-C and other proteins are critical for initial 5'SS recognition. Purified U1 snRNP/RNA oligonucleotide binding kinetics, RNase H cleavage, UV crosslinking The Journal of biological chemistry Medium 8798632
2001 Specific mutations in U1-C (or in U1 snRNA) can bypass the otherwise essential requirement for the DEAD-box ATPase Prp28p in yeast. The conserved L13 residue of U1-C makes specific contact that stabilizes the U1 snRNA/5' splice site duplex in the prespliceosome; Prp28p functions to counteract this stabilizing effect of U1-C, promoting U1 snRNP dissociation from the 5' splice site. Genetic epistasis (suppressor mutations), yeast mutant growth assays, structure-function analysis of U1-C mutations Molecular cell High 11172727
2002 The splicing regulator TIA-1 directly and specifically interacts with the N-terminal region of U1-C via its C-terminal glutamine-rich (Q) domain (enhanced by RRM1), and this interaction promotes U1 snRNP recruitment to weak 5' splice sites. Co-precipitation experiments established the direct U1-C/TIA-1 interaction. Co-precipitation/pulldown experiments with recombinant protein fragments, RNA recognition motif deletion analysis, splicing assays The EMBO journal High 12486009
2009 Crystal structure of human U1 snRNP at 5.5 Å resolution, with site-specific labelling used to place U1-C and other proteins. U1-C is positioned such that the N-terminal polypeptide of U1-70K wraps around the Sm core and makes contact with U1-C, suggesting U1-C is crucial for 5' splice site recognition and revealing a hierarchical network of protein–protein and RNA–protein interactions. X-ray crystallography at 5.5 Å, site-specific protein labelling for subunit placement Nature High 19325628
2009 Mass spectrometry analysis of native human U1 snRNP revealed that U1-C undergoes dynamic interactions with the complex; its unstructured, post-translationally modified C-terminal tail is responsible for its dynamic exchange, and this interaction is controlled by binding to different U1-70K isoforms and their phosphorylation status in vivo. Native mass spectrometry of purified U1 snRNP, comparison of native vs. recombinant complexes PloS one Medium 19784376
2014 Mutational analysis of yeast Yhc1 (U1-C ortholog) identified that Arg21 and other surface residues stabilize the U1–5'SS complex. Yhc1-R21A is synthetically lethal without Mud2 and bypasses the essentiality of Prp28, consistent with destabilization of U1•5'SS interaction. Yhc1 Arg21 fortifies the U1•5'SS complex via contacts with SmD3 residues Glu37/Asp38. Alanine-scanning mutagenesis, yeast genetic interaction screens (synthetic lethality, bypass suppression), growth assays Nucleic acids research High 24497193
2015 Atomic-resolution crystal structures of engineered human U1 sub-structures showed that the zinc finger of U1-C interacts with the RNA duplex formed between the pre-mRNA 5' splice site and U1 snRNA, stabilizing it through hydrogen bonds and electrostatic interactions with the RNA backbone. U1-C makes no base-specific contacts with pre-mRNA; 5'SS selection is achieved predominantly through base pairing with U1 snRNA, while U1-C fine-tunes relative affinities for mismatched 5'SS. X-ray crystallography (atomic resolution), RNA binding assays eLife High 25555158
2015 Extended genetic analysis in yeast confirmed that Yhc1 Val20 and Ser19 at the RNA interface are important for U1•5'SS complex stability; mutations V20A and S19A bypassed the essentiality of Prp28, consistent with destabilization of U1•5'SS interaction. Yhc1 interface mutations with SmD3, SmB, and U1-70K/Snp1 elicited synthetic defects in the absence of U1 subunit Mud1. Alanine-scanning mutagenesis, yeast genetic interaction assays (synthetic lethality, bypass of Prp28 essentiality) RNA (New York, N.Y.) Medium 25897024
2018 Cryo-EM structures of the yeast pre-B and B spliceosomal complexes showed that in the pre-B complex, the duplex between the 5' splice site and U1 snRNA is recognized by Yhc1 (U1-C ortholog), Luc7, and the Sm ring. In the B complex, U1 snRNP is dissociated from the 5'SS. Cryo-electron microscopy at 3.3–4.6 Å resolution Science (New York, N.Y.) High 29794219
2022 Knockdown or overexpression of SNRPC (along with other free U1 snRNP proteins SNRPA, SNRNP70, SNRPD2) promotes usage of proximal alternative polyadenylation (APA) sites at the transcriptome level. SNRNP70 (but not SNRPC specifically) was shown to interact with CPSF6 to promote proximal APA; the mechanism for SNRPC in APA was not individually resolved beyond the transcriptome-level effect. siRNA knockdown, overexpression, transcriptome-level APA analysis Journal of molecular cell biology Low 36073763
2023 SNRPC is essential for the stability of U1 snRNP and contributes to RNA Pol II-controlled transcription of oncogenes. SNRPC ablation (CRISPR) decreased RNA Pol II enrichment on a subset of oncogenes (TNFAIP2, E2F2, CDK4) and reduced their expression. SNRPC deletion inhibited TNBC progression partially through regulation of the TNFAIP2-Rac1-β-catenin signaling pathway. In vivo CRISPR screen, CRISPR knockout, RNA Pol II ChIP, functional cell assays (proliferation, migration, invasion), in vivo tumor models Cancer research Medium 37057875
2024 Single-molecule and ensemble kinetic studies established that U1-C protein binds reversibly to U1 snRNP (it is a dynamic subunit), and the small-molecule splicing modulator branaplam binds to the U1 snRNP/U1-C complex only after the complex has engaged with a -1A bulged 5' splice site. This obligate sequential binding explains how branaplam stabilizes long-lived U1 snRNP/5'SS complexes. Colocalization single-molecule spectroscopy (CoSMoS), ensemble kinetic measurements Nature communications High 39389991
2011 TIA-1 RRM1 enhances the interaction of TIA-1's C-terminal Q-rich domain with U1-C, despite linear separation of the domains. SAXS showed TIA-1 adopts a 'V' shape that brings N- and C-termini to the same side, structurally rationalizing how RRM1 can facilitate U1-C contact. Isothermal titration calorimetry, small-angle X-ray scattering (SAXS), RNA binding assays with TIA-1 deletion variants Journal of molecular biology Medium 22154808
1997 The U1-C protein (Yhc1) was identified as a component of yeast U1 snRNP by mass spectrometry peptide sequencing of a purified yeast U1 snRNP complex, establishing its presence as a U1-specific protein in Saccharomyces cerevisiae. Anti-m3G cap immunoaffinity purification, glycerol gradient centrifugation, nanoelectrospray mass spectrometry Proceedings of the National Academy of Sciences of the United States of America Medium 9012791

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution. Nature 282 19325628
2015 Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition. eLife 220 25555158
2002 The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites. The EMBO journal 189 12486009
2001 Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD box splicing factor. Molecular cell 167 11172727
1997 Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 163 9012791
1994 The association of the U1-specific 70K and C proteins with U1 snRNPs is mediated in part by common U snRNP proteins. The EMBO journal 116 8076607
2013 Welander distal myopathy caused by an ancient founder mutation in TIA1 associated with perturbed splicing. Human mutation 95 23348830
2018 Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation. Science (New York, N.Y.) 79 29794219
1996 In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes. Nucleic acids research 77 8972845
2010 Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease. Arthritis and rheumatism 53 20722023
1991 Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP. Nucleic acids research 50 1826349
2007 Importance of spliceosomal RNP1 motif for intermolecular T-B cell spreading and tolerance restoration in lupus. Arthritis research & therapy 46 17963484
2004 Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometry. The Journal of biological chemistry 45 15525645
2009 Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP. PloS one 44 19784376
1996 Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein. The Journal of clinical investigation 39 8647956
2011 Three RNA recognition motifs participate in RNA recognition and structural organization by the pro-apoptotic factor TIA-1. Journal of molecular biology 34 22154808
2017 Sex influences eQTL effects of SLE and Sjögren's syndrome-associated genetic polymorphisms. Biology of sex differences 32 29070082
1996 Involvement of U1 small nuclear ribonucleoproteins (snRNP) in 5' splice site-U1 snRNP interaction. The Journal of biological chemistry 32 8798632
1993 B cell epitope on the U1 snRNP-C autoantigen contains a sequence similar to that of the herpes simplex virus protein. European journal of immunology 32 7682956
2018 Omics approach reveals metabolic disorders associated with the cytotoxicity of airborne particulate matter in human lung carcinoma cells. Environmental pollution (Barking, Essex : 1987) 31 30529940
2023 An In Vivo CRISPR Screen Identifies That SNRPC Promotes Triple-Negative Breast Cancer Progression. Cancer research 20 37057875
2014 Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28. Nucleic acids research 20 24497193
1997 Human anti-nuclear ribonucleoprotein antigen autoimmune sera contain a novel subset of autoantibodies that stabilizes the molecular interaction of U1RNP-C protein with the Sm core proteins. Journal of immunology (Baltimore, Md. : 1950) 20 9144522
2022 Impact of bisphenol-A on the spliceosome and meiosis of sperm in the testis of adolescent mice. BMC veterinary research 18 35841026
2015 Structure-function analysis and genetic interactions of the Yhc1, SmD3, SmB, and Snp1 subunits of yeast U1 snRNP and genetic interactions of SmD3 with U2 snRNP subunit Lea1. RNA (New York, N.Y.) 17 25897024
2022 U1 snRNP proteins promote proximal alternative polyadenylation sites by directly interacting with 3' end processing core factors. Journal of molecular cell biology 13 36073763
2024 A sequential binding mechanism for 5' splice site recognition and modulation for the human U1 snRNP. Nature communications 12 39389991
2021 SNRPC promotes hepatocellular carcinoma cell motility by inducing epithelial-mesenchymal transition. FEBS open bio 12 33934562
2001 A diepitopic sequential oligopeptide carrier (SOCn) as mimic of the sm autoantigen: synthesis, conformation and biological assays. Journal of peptide science : an official publication of the European Peptide Society 9 11277497
2024 Evidence that autoantibody production may be driven by acute Epstein-Barr virus infection in Sjögren's disease. Annals of the rheumatic diseases 8 39472059
2001 Purification of Drosophila snRNPs and characterization of two populations of functional U1 particles. RNA (New York, N.Y.) 8 11333025
2020 Profiling of cis- and trans-acting factors supporting noncanonical splice site activation. RNA biology 7 32693676
2006 Identification of a putative oocyte-specific small nuclear ribonucleoprotein polypeptide C in gibel carp. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 7 17049898
1994 HLA class II genes and antibodies against recombinant U1-nRNP proteins in patients with systemic lupus erythematosus. SLE Study Group. Rheumatology international 7 7824837
2015 The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub. The Journal of biological chemistry 6 26483546
2024 New daphnane diterpenoidal 1,3,4-oxdiazole derivatives as potential anti-hepatoma agents: Synthesis, biological evaluation and molecular modeling studies. Bioorganic chemistry 5 38354501
2024 Comprehensive analysis of m6A methylome alterations after azacytidine plus venetoclax treatment for acute myeloid leukemia by nanopore sequencing. Computational and structural biotechnology journal 4 38510975
2004 Autoantibodies that stabilize U1snRNP are a significant component of human autoantibodies to snRNP and delay proteolysis of sm antigens in vitro. The Journal of rheumatology 3 15570638
1997 Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C. Gene 3 9031639
2026 New autoantibodies in Sjögren's disease. Current opinion in immunology 2 41534451
2024 A Sequential Binding Mechanism for 5' Splice Site Recognition and Modulation for the Human U1 snRNP. bioRxiv : the preprint server for biology 2 38659798
2024 Functional analysis of the zinc finger modules of the Saccharomyces cerevisiae splicing factor Luc7. RNA (New York, N.Y.) 2 38719745
1995 Reconstitution of exon-bridging activity with purified U2AF and U1 snRNP components. Nucleic acids symposium series 2 8643375
2026 SNRPC promotes chemoresistance in Wilms tumor via the NF-κB-CXCL17 axis regulating M2-Type TAMs infiltration and targeted nanotherapy research. Journal of experimental & clinical cancer research : CR 0 41761364
2024 Functional Analysis of the Zinc Finger Modules of the S. cerevisiae Splicing Factor Luc7. bioRxiv : the preprint server for biology 0 38352541

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