Affinage

STX12

Syntaxin-12 · UniProt Q86Y82

Length
276 aa
Mass
31.6 kDa
Annotated
2026-06-10
46 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

STX12 (also called STX13) is a recycling/sorting-endosomal Qa-SNARE that drives membrane fusion across multiple trafficking pathways by assembling with cognate partner SNAREs (PMID:26208634, PMID:40335523, PMID:42265296). In melanocytes it mediates cargo delivery to maturing melanosomes in partnership with the R-SNARE VAMP7, on which it is mutually dependent for localization; its N-terminal regulatory domain restrains SNARE activity, and deleting that domain enhances both complex assembly and cargo transport (PMID:26208634). STX12 is phosphorylated at Ser139 by the endosomal kinase SGK3, which strengthens its incorporation into VAMP4/VTI1A/STX6-containing SNARE complexes and promotes its plasma-membrane localization (PMID:31665227). Through these fusion activities STX12 supports autophagosome maturation, where its loss blocks autophagic flux and accumulates LC3/Atg5 puncta in cooperation with Vti1a and the ESCRT-III machinery (PMID:24095276), and contributes to organelle biogenesis programs including platelet alpha-granule formation via binding to VPS16B/VPS33B (PMID:34905616), acrosome biogenesis via the tethering factor ELAPOR1 (PMID:40737321), unconventional galectin secretion through an STX13-SNAP23-VAMP3 complex on ATG9A vesicles (PMID:40335523), and MR1-mediated antigen presentation at sorting endosomes (PMID:42215548). STX12-dependent trafficking is also exploited by pathogens, as the Chlamydia effector IncE recruits STX12-containing vesicles via an R-SNARE-mimetic motif (PMID:39154341), and it promotes invadopodia-dependent tumor invasion by delivering Src and EGFR to invadopodia together with SNAP23 (PMID:24496451). Genetic loss of STX12 in mice and zebrafish causes mitochondrial dysfunction, mtDNA release with cGAS-STING/type I interferon activation, perinatal lethality with pulmonary inflammation, and cardiac failure with impaired SERCA activity (PMID:40200300, PMID:40568929); the mechanistic connection between its SNARE function and these mitochondrial and cardiomyocyte phenotypes has not been resolved in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2013 High

    Established that STX12/STX13 acts in the autophagy pathway, addressing whether this endosomal SNARE contributes to autophagosome maturation rather than only endosomal recycling.

    Evidence siRNA knockdown with LC3/Atg5 puncta imaging and EM in mammalian cells plus a Drosophila genetic modifier screen against ESCRT-III mutant CHMP2B

    PMID:24095276

    Open questions at the time
    • Does not define which partner SNAREs assemble at the phagophore-to-autophagosome step
    • Molecular relationship to ESCRT-III is genetic, not biochemical
  2. 2014 Medium

    Showed STX12-mediated trafficking delivers signaling cargo to invadopodia, linking the SNARE to tumor cell invasion machinery.

    Evidence Reciprocal co-IP, SNARE inhibition, invadopodia and matrix degradation/invasion assays

    PMID:24496451

    Open questions at the time
    • Does not identify the vesicle population trafficking Src/EGFR
    • Single-lab functional study without in vivo validation
  3. 2015 High

    Defined STX12 as a recycling-endosomal Qa-SNARE that requires VAMP7 and is autoinhibited by its N-terminal domain, establishing the core fusion mechanism in melanosome cargo delivery.

    Evidence siRNA knockdown, live-cell imaging, EM, N-terminal domain-deletion mutagenesis and pigmentation assay in melanocytes

    PMID:26208634

    Open questions at the time
    • Does not resolve the Qbc-SNARE partner in the melanosomal complex
    • Regulation of the N-terminal autoinhibition in cells not defined
  4. 2019 High

    Identified post-translational control of STX12 by SGK3 phosphorylation at Ser139, answering how its SNARE assembly and localization are regulated by upstream signaling.

    Evidence Phosphoproteomic screen, in vitro kinase assay, Phos-tag, SGK3 knockout cells and pan-SGK inhibition under IGF1 stimulation

    PMID:31665227

    Open questions at the time
    • Phenotypic consequence of Ser139 phosphorylation on specific trafficking pathways not mapped
    • Phosphatase reversing the modification unknown
  5. 2020 Medium

    Placed STX12 downstream of a mitochondrial-ROS/STAT3/NFE2L1 transcriptional axis, addressing how its expression is controlled in cancer cells.

    Evidence cDNA microarray, NFE2L1 gain/loss of function, ROS measurement, STAT3 inhibition and invasion assay in hepatoma cells

    PMID:32942643

    Open questions at the time
    • Direct promoter binding by NFE2L1 not demonstrated
    • Link between transcriptional induction and SNARE activity unresolved
  6. 2021 Medium

    Demonstrated that STX12's endosomal SNARE complex can be competitively inhibited by tSNARE1, defining a regulatory point in early-to-late endosomal trafficking.

    Evidence Biochemical competition for SNARE complex incorporation, live-cell imaging, RNA-seq

    PMID:34642214

    Open questions at the time
    • STX12 was supporting data to a tSNARE1-focused study
    • Full subunit composition of the competed complex not defined
  7. 2022 High

    Linked STX12 to platelet alpha-granule biogenesis through binding VPS16B/VPS33B, and revealed a hand-off mechanism with the CCC complex coordinating endosomal entry and retrieval.

    Evidence Reciprocal co-IP, Stx12 knockdown/knockout megakaryocytes, EM granule quantification, competitive binding with CCDC22

    PMID:34905616

    Open questions at the time
    • Fusion partner SNAREs in granule biogenesis not enumerated
    • Structural basis of VPS16B/VPS33B versus CCDC22 competition unknown
  8. 2023 Medium

    Showed STX12 is a target of miR-31 in a bacterially driven regulatory loop controlling autophagic flux in colorectal cancer.

    Evidence miR-31 gain/loss, STX12 knockdown, autophagic flux assay, luciferase reporter for direct targeting

    PMID:37216106

    Open questions at the time
    • Does not show the trafficking step at which autophagy is blocked
    • In vivo relevance of the loop not established
  9. 2024 Medium

    Revealed pathogen subversion of STX12 trafficking, with the Chlamydia effector IncE recruiting STX12-containing vesicles via an R-SNARE-mimetic linear motif.

    Evidence SLiM mutant analysis, pulldown/binding assays, imaging of vesicle recruitment to the bacterial inclusion

    PMID:39154341

    Open questions at the time
    • Functional benefit to the bacterium of STX12 vesicle capture not fully quantified
    • Whether IncE engages STX12 directly or via the SNARE complex unclear
  10. 2025 Medium

    Extended STX12 to additional fusion-dependent processes—galectin secretion, MR1 antigen presentation, and acrosome biogenesis—defining its partner SNAREs and tethering factors in each.

    Evidence SNARE KD/KO and co-IP with galectin-9 secretion assay (STX13-SNAP23-VAMP3); siRNA with MR1 flow cytometry and MAIT activation; co-IP and conditional germ-cell Stx12 KO with acrosome EM (ELAPOR1)

    PMID:40335523 PMID:40737321 PMID:42215548

    Open questions at the time
    • Whether a single endosomal pool serves these diverse pathways is unknown
    • Regulation distinguishing these pathways not defined
  11. 2025 Medium

    Uncovered organismal phenotypes of STX12 loss—mitochondrial dysfunction with cGAS-STING activation, perinatal lethality, and cardiac failure—raising the question of how SNARE activity connects to mitochondrial and cardiomyocyte homeostasis.

    Evidence Stx12 knockout mice and zebrafish depletion with mitochondrial membrane potential, complex subunit blots, interferon qPCR, echocardiography, SERCA activity assay and rapamycin rescue

    PMID:40200300 PMID:40568929

    Open questions at the time
    • Direct mechanistic link between SNARE fusion activity and mitochondrial integrity not established
    • Whether cardiac and pulmonary phenotypes are cell-autonomous is unresolved
  12. 2026 Medium

    Defined upstream activators and regulators of STX12 SNARE assembly and its endosomal subdomain identity in EV biogenesis, anti-apoptotic signaling, and alpha-granule sorting.

    Evidence Co-IP and SNARE assembly assays with PKM2/SNAP23 perturbation (Coro1a/EV); RIP and STX12 KD with apoptosis readouts and xenografts (SF3A1); co-localization and GRIPAP1 mitochondrial mislocalization with cargo tracking (Rab4a subdomain)

    PMID:41632639 PMID:41683622 PMID:42265296

    Open questions at the time
    • Causal contribution of STX12 fusion to apoptosis resistance not mechanistically dissected
    • How SNAP23 phosphorylation selectively recruits STX12 is unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown how STX12's well-defined endosomal SNARE fusion activity mechanistically produces the mitochondrial dysfunction and cardiomyocyte/cardiac phenotypes seen on its loss.
  • No demonstrated SNARE-dependent trafficking event upstream of mitochondrial integrity
  • No structural model of STX12 SNARE complexes across its diverse pathways

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0060090 molecular adaptor activity 3 GO:0140096 catalytic activity, acting on a protein 1
Localization
GO:0005768 endosome 4 GO:0005886 plasma membrane 2 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-9609507 Protein localization 2 R-HSA-9612973 Autophagy 2
Partners
ELAPOR1SGK3SNAP23VAMP3VAMP7VPS16BVPS33BVTI1A
Complex memberships
STX12-SNAP23-VAMP7 SNARE complexSTX13-SNAP23-VAMP3 SNARE complexVAMP4/VTI1A/STX6 SNARE complex

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 STX13 (STX12) is required for autophagosome maturation: knockdown of STX13 or its binding partner Vti1a in mammalian cells caused LC3-positive puncta accumulation and blocked autophagic flux. STX13 was present on LC3-positive phagophores and was highly enriched on multilamellar structures induced by dysfunctional ESCRT-III. Loss of STX13 also caused accumulation of Atg5-positive puncta and multilamellar structure formation, suggesting STX13 participates in phagophore-to-autophagosome maturation. Genetically, Drosophila syx13 exhibited strong genetic interaction with mutant CHMP2B (ESCRT-III component). siRNA knockdown in mammalian cells, live-cell imaging (LC3/Atg5 puncta), Drosophila genetic modifier screen, electron microscopy Molecular cell High 24095276
2014 STX12 (syntaxin13) and SNAP23 mediate membrane trafficking required for invadopodia formation and tumor cell invasion. The association of Src, EGFR, and β1 integrin at invadopodia is dependent on STX12/SNAP23-mediated traffic. Inhibition of SNARE function impaired delivery of Src and EGFR to developing invadopodia and blocked β1-integrin-dependent Src activation and EGFR phosphorylation (Tyr845). β1 integrin inhibition increased SNAP23–β1 integrin association and reduced STX12–SNAP23 interaction. Co-immunoprecipitation, SNARE inhibition, live-cell imaging of invadopodia, matrix degradation assay, invasion assay Journal of cell science Medium 24496451
2015 STX13 (STX12), a recycling endosomal Qa-SNARE, is required for cargo delivery to maturing melanosomes. Depletion of STX13 in melanocytes reroutes melanosomal proteins TYR and TYRP1 to lysosomes. Live-cell imaging and EM showed STX13 co-distributes with melanosomal cargo in tubular-vesicular endosomes associated with maturing melanosomes. Deletion of the N-terminal regulatory domain of STX13 increases SNARE activity in vivo and melanosome cargo transport. STX13-dependent cargo transport requires the R-SNARE VAMP7; silencing VAMP7 blocks melanosome maturation, and STX13 and VAMP7 show mutual dependency for their localization. siRNA knockdown, live-cell imaging, electron microscopy, domain-deletion mutagenesis, pigmentation assay Journal of cell science High 26208634
2019 STX12 is a substrate of the endosomal kinase SGK3: SGK3 phosphorylates STX12 at Ser139 in vitro and in cells stimulated with IGF1. This phosphorylation is blocked by SGK3 knockout or pan-SGK inhibitor. SGK3 phosphorylation of STX12 enhanced interaction with the VAMP4/VTI1A/STX6-containing SNARE complex and promoted plasma membrane localization of STX12. Phosphoproteomic screen, in vitro kinase assay, Phos-tag analysis, SGK3 knockout cells, pharmacological inhibition The Biochemical journal High 31665227
2020 STX12 expression is upregulated through a ROS/STAT3/NFE2L1 transcriptional axis downstream of mitochondrial respiratory defects in hepatoma cells. NFE2L1 was identified as a direct transcriptional regulator of STX12 by cDNA microarray after NFE2L1 overexpression/depletion. STX12 functions as a key downstream effector of NFE2L1 modulating hepatoma cell invasiveness. cDNA microarray, NFE2L1 overexpression/depletion, ROS measurement, STAT3 inhibition, invasion assay, immunohistochemistry Cancers Medium 32942643
2021 tSNARE1, a schizophrenia-risk protein, competes with STX12 for incorporation into an endosomal SNARE complex, supporting a role for tSNARE1 as an inhibitory SNARE that negatively regulates early-to-late endosomal trafficking in which STX12 participates. Biochemical competition assay (SNARE complex incorporation), live-cell imaging, RNA-sequencing The Journal of neuroscience Medium 34642214
2022 STX12 (Stx12) physically associates with VPS16B/VPS33B and is required for platelet α-granule biogenesis in megakaryocytes. Stx12-deficient megakaryocytes display reduced α-granule numbers and overall α-granule protein levels. CCDC22 (CCC complex) competes with Stx12 for binding to VPS16B/VPS33B, suggesting a hand-off mechanism between endosomal entry (Stx12-mediated fusion) and exit (CCC-mediated retrieval). Co-immunoprecipitation, Stx12 knockdown/knockout in megakaryocytes, α-granule quantification by electron microscopy, competitive binding assay Blood High 34905616
2024 The Chlamydia trachomatis effector IncE recruits STX7- and STX12-containing vesicles to the bacterial inclusion via a short linear motif (SLiM) in its cytosolic C-terminus that mimics an R-SNARE motif, binding STX12-containing vesicles to facilitate intracellular bacterial development. SLiM mutant analysis, pulldown/binding assays, fluorescence imaging of vesicle recruitment to inclusion Cell reports Medium 39154341
2023 F. nucleatum infection promotes miR-31 expression in colorectal cancer cells; miR-31 inhibits autophagic flux by targeting STX12. STX12 knockdown phenocopied miR-31 overexpression in blocking autophagy, and STX12, miR-31, and F. nucleatum form a regulatory loop in the autophagy pathway. miR-31 overexpression/knockout, STX12 knockdown, autophagic flux assay (LC3 accumulation), luciferase reporter for miR-31 targeting of STX12 iScience Medium 37216106
2025 STX12 deficiency causes depolarization of mitochondrial membrane potential, reduced mitochondrial complex subunit levels, mitochondrial DNA (mtDNA) release into the cytoplasm, and activation of the cGAS-STING pathway and Type I interferon pathway in lung tissue of Stx12-/- mice. Stx12 knockout mice exhibit perinatal lethality with severe pulmonary inflammation, neutrophil infiltration, and increased cytokines. Stx12 knockout mice, zebrafish Stx12 depletion, mitochondrial membrane potential measurement (JC-1), Western blot for complex subunits, qPCR for interferon genes, immunohistochemistry Cell communication and signaling : CCS Medium 40200300
2025 STX12 loss in zebrafish and mice causes pericardial edema, cardiac malformations, and heart failure associated with disrupted mitochondrial morphology, reduced iron and zinc, impaired ATP production, and prolonged cardiomyocyte repolarization due to decreased SERCA activity. Rapamycin treatment restores mitochondrial protein expression via TFEB-PGC1α and enhances SERCA activity via CAMKII-phospholamban pathway. Zebrafish morpholino knockdown, mouse Stx12 knockout, echocardiography, mitochondrial morphology EM, ATP measurement, metal quantification, SERCA activity assay, rapamycin treatment Advanced science Medium 40568929
2025 ELAPOR1, a tethering factor for proacrosomal vesicle fusion during acrosome biogenesis, physically interacts with STX12. Conditional knockout of Stx12 in germ cells resulted in defective acrosome biogenesis similar to Elapor1-/- mice, establishing STX12 as part of the vesicle fusion machinery for acrosome formation. Co-immunoprecipitation, conditional Stx12 knockout in germ cells, acrosome morphology by fluorescence and electron microscopy Proceedings of the National Academy of Sciences Medium 40737321
2025 ATG9A vesicles fuse with the plasma membrane via an STX13-SNAP23-VAMP3 SNARE complex to secrete galectin-9 and other proteins (galectin-4, galectin-8, annexin A6) in an autophagy-independent unconventional secretion pathway. SNARE knockdown/knockout, co-immunoprecipitation, live-cell imaging of vesicle fusion, galectin-9 secretion assay Nature communications Medium 40335523
2025 STX12 knockdown reduces MR1 antigen presentation of Mycobacterium tuberculosis-derived ligands to MAIT cells in airway epithelial cells. Stx12 blockade increases MR1 surface stabilization and total MR1 expression, indicating that STX12-dependent endosomal trafficking is required for MR1 internalization and antigen loading at sorting endosomes. siRNA-mediated knockdown, MR1 surface expression by flow cytometry, MR1-GFP co-localization imaging, MAIT cell activation assay Scientific reports Medium 42215548
2026 Coronin-1a (Coro1a) promotes extracellular vesicle biogenesis by facilitating assembly of the STX12-SNAP23-VAMP7 SNARE complex to drive multivesicular body–plasma membrane fusion. Coro1a activates PKM2 to phosphorylate SNAP23, which recruits STX12 and VAMP7 into the SNARE complex; this effect is abolished by PKM2 inhibition or SNAP23 silencing. Co-immunoprecipitation, SNARE complex assembly assay, PKM2 inhibition, SNAP23 knockdown, EV quantification Communications biology Medium 42265296
2026 SF3A1 (splicing factor 3A1) stabilizes STX12 mRNA in colorectal cancer cells; STX12 functions downstream of SF3A1 to inhibit apoptosis. Knockdown of STX12 alone induces apoptosis in CRC cells (but not non-cancerous cells), and SF3A1 knockdown reduces STX12 mRNA levels, establishing an SF3A1–STX12 anti-apoptotic axis in CRC. RNA-immunoprecipitation (RIP), STX12 knockdown, TUNEL staining, PARP cleavage, caspase-3/7 activity, xenograft mouse model International journal of molecular sciences Medium 41683622
2026 GRIPAP1, an endosomal tethering factor for platelet α-granule biogenesis, localizes to endosome subdomains decorated by Rab4a and Stx12. Artificial mislocalization of GRIPAP1 to mitochondria was sufficient to recruit Rab4a/Stx12 compartments containing internalized transferrin and newly synthesized PF4 to mitochondria, indicating that Stx12 marks a specific Rab4a-positive endosomal subdomain involved in α-granule cargo sorting. Co-localization imaging, artificial mitochondrial targeting of GRIPAP1, transferrin trafficking assay, PF4 trafficking assay The Journal of cell biology Medium 41632639

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 Virulence-associated genes in avian pathogenic Escherichia coli (APEC) isolated from internal organs of poultry having died from colibacillosis. International journal of medical microbiology : IJMM 119 11727821
2015 Multiple antibiotic resistances among Shiga toxin producing Escherichia coli O157 in feces of dairy cattle farms in Eastern Cape of South Africa. BMC microbiology 72 26475706
2013 Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation. Molecular cell 61 24095276
2014 SNARE-dependent interaction of Src, EGFR and β1 integrin regulates invadopodia formation and tumor cell invasion. Journal of cell science 59 24496451
2019 Predictors of Enteric Pathogens in the Domestic Environment from Human and Animal Sources in Rural Bangladesh. Environmental science & technology 58 31356066
2008 A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 54 18937310
2015 STX13 regulates cargo delivery from recycling endosomes during melanosome biogenesis. Journal of cell science 45 26208634
2017 A review on strategies for decreasing E. coli O157:H7 risk in animals. Microbial pathogenesis 42 28062285
2020 The ZIP Code of Vesicle Trafficking in Apicomplexa: SEC1/Munc18 and SNARE Proteins. mBio 31 33082261
2014 New high-affinity monoclonal antibodies against Shiga toxin 1 facilitate the detection of hybrid Stx1/Stx2 in vivo. PloS one 31 24914553
2023 MicroRNA-31 induced by Fusobacterium nucleatum infection promotes colorectal cancer tumorigenesis. iScience 29 37216106
2014 Evaluation of real time PCR assays for the detection and enumeration of enterohemorrhagic Escherichia coli directly from cattle feces. Journal of microbiological methods 27 25064761
2019 Transcriptional and Translational Inhibitors Block SOS Response and Shiga Toxin Expression in Enterohemorrhagic Escherichia coli. Scientific reports 26 31827185
2020 Mitochondrial Respiratory Defect Enhances Hepatoma Cell Invasiveness via STAT3/NFE2L1/STX12 Axis. Cancers 25 32942643
2022 Syntaxin 12 and COMMD3 are new factors that function with VPS33B in the biogenesis of platelet α-granules. Blood 21 34905616
2021 Schizophrenia-Linked Protein tSNARE1 Regulates Endosomal Trafficking in Cortical Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 17 34642214
2019 Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44. The Biochemical journal 16 31665227
2022 Long read sequencing and expression studies of AHDC1 deletions in Xia-Gibbs syndrome reveal a novel genetic regulatory mechanism. Human mutation 14 36054313
2018 Syntaxin clusters at secretory granules in a munc18-bound conformation. Molecular biology of the cell 14 30156474
2023 Identification and validation of the reference genes in the echiuran worm Urechis unicinctus based on transcriptome data. BMC genomics 13 37165306
2006 Integrative strategies to identify candidate genes in rodent models of human alcoholism. Genome 12 16462896
2017 STX12 lncRNA/miR-148a/SMAD5 participate in the regulation of pancreatic stellate cell activation through a mechanism involving competing endogenous RNA. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 11 28202235
2024 Age-dependent functional development pattern in neonatal brain: An fMRI-based brain entropy study. NeuroImage 10 38852805
2013 Detection and isolation of Shiga toxin-producing Escherichia coli (STEC) O104 from sprouts. International journal of food microbiology 10 24413585
2019 Risk of acquisition of human diarrhoeagenic Escherichia coli virulence genes in intercontinental travellers: A prospective, multi-centre study. Travel medicine and infectious disease 9 30609386
2024 The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking. Cell reports 7 39154341
2023 Syntaxin 3 SPI-2 dependent crosstalk facilitates the division of Salmonella containing vacuole. Traffic (Copenhagen, Denmark) 7 37114883
2022 Transgenic Sweet Orange Expressing the Sarcotoxin IA Gene Produces High-Quality Fruit and Shows Tolerance to 'Candidatus Liberibacter asiaticus'. International journal of molecular sciences 7 36012564
2025 Autophagy-independent role of ATG9A vesicles as carriers for galectin-9 secretion. Nature communications 6 40335523
2025 Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice. Cell communication and signaling : CCS 5 40200300
2025 Mutation T9I in Envelope confers autophagy resistance to SARS-CoV-2 Omicron. iScience 5 40687831
2021 Antimicrobial resistance and molecular genotyping of Escherichia coli and Staphylococcus aureus isolated from some Egyptian cheeses. Journal of advanced veterinary and animal research 5 34395595
2025 ELAPOR1 is a copper-dependent tethering factor driving proacrosomal vesicle fusion during acrosome biogenesis. Proceedings of the National Academy of Sciences of the United States of America 4 40737321
2021 The Deleterious Effects of Shiga Toxin Type 2 Are Neutralized In Vitro by FabF8:Stx2 Recombinant Monoclonal Antibody. Toxins 4 34822608
2025 Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 3 40568929
2026 GRIPAP1 is an endosomal tethering factor mediating platelet α-granule biogenesis. The Journal of cell biology 1 41632639
2025 The diverse functions of syntaxin 13 in endosome-mediated membrane fusion. International journal of biological macromolecules 1 40058431
2025 The Impact of Obesity on Autophagy in Human Adipose-Derived Mesenchymal Stromal Cells. Cell transplantation 1 40116436
2022 The Microscopy-Based Assay to Study and Analyze the Recycling Endosomes using SNARE Trafficking. Journal of visualized experiments : JoVE 1 35225263
2026 Splicing Factor 3a Subunit 1 Promotes Colorectal Cancer Growth via Anti-Apoptotic Effects of Syntaxin12. International journal of molecular sciences 0 41683622
2026 The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity. Autism research : official journal of the International Society for Autism Research 0 41844341
2026 Sorting endosomes play key roles in presentation of Mycobacterium tuberculosis-derived ligands to MAIT cells. Scientific reports 0 42215548
2026 Coro1a promotes the multivesicular body and plasma membrane fusion by facilitating PKM2-mediated SNAP-23 phosphorylation. Communications biology 0 42265296
2025 Identification of Novel Protein Biomarkers for Intrahepatic Cholangiocarcinoma by Integrating Human Plasma Proteome with Genome. Journal of gastrointestinal cancer 0 40240670
2025 Sorting endosomes play key roles in presentation of Mycobacterium tuberculosis -derived ligands to MAIT cells. bioRxiv : the preprint server for biology 0 41573916
2023 Does pre-incubation in selective-enrichment media improve the detection of diarrheagenic Escherichia coli using the RIDA®GENE PCR? International journal of medical microbiology : IJMM 0 36736015

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