Affinage

VAMP7

Vesicle-associated membrane protein 7 · UniProt P51809

Length
220 aa
Mass
24.9 kDa
Annotated
2026-06-11
85 papers in source corpus 56 papers cited in narrative 56 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

VAMP7 (TI-VAMP/SYBL1) is a longin-family vesicular SNARE that drives membrane fusion across multiple late endosomal–lysosomal and unconventional secretory pathways (PMID:10459012, PMID:10888671). Its activity is gated by its N-terminal Longin domain, which folds back onto the SNARE helix to adopt a preferentially closed, autoinhibited conformation in solution (PMID:20378544); this domain inhibits SNARE complex assembly, and its removal increases SNARE pairing and potently stimulates VAMP7-dependent membrane fusion such as neurite outgrowth (PMID:10811829). Autoinhibition is relieved physiologically by c-Src–mediated phosphorylation of tyrosine 45 in the Longin domain, which activates t-SNARE binding and exocytosis (PMID:23471971), and is reinforced by Varp, whose ankyrin repeat domain traps the VAMP7 SNARE motif against the Longin domain to kinetically block complex formation (PMID:23104059). Once activated, VAMP7 assembles into compartment-specific SNARE complexes—with Syntaxin 7/Vti1b/Syntaxin 8 for late endosome–lysosome fusion (PMID:12175335, PMID:15133481), and with SNAP-23/syntaxin partners at the plasma membrane for regulated secretion in immune and tumor cells (PMID:18253931, PMID:24807903, PMID:31447853). Through these complexes VAMP7 executes late endosome-to-lysosome transport (PMID:10459012, PMID:10888671), lysosomal and secretory-granule exocytosis underlying phagocytosis, immune-cell degranulation and cytokine release (PMID:15470500, PMID:21805468, PMID:26972013), autophagosome–lysosome fusion (PMID:19781582, PMID:26953164), cell-surface delivery of selected cargoes including ion channels (PMID:26843440), and neuronal axon extension (PMID:21740490). The Longin domain additionally serves as a sorting platform recognized by the AP-3 δ-adaptin subunit and the clathrin adaptor Hrb to direct VAMP7 recycling and endocytic retrieval, interactions whose structural basis has been defined by crystallography (PMID:18775314, PMID:22521722). VAMP7 knockout mice establish selective in vivo roles in neurite outgrowth, anxiety behavior, sensory cold detection, and β-cell autophagy and insulin secretion (PMID:21740490, PMID:22323709, PMID:26843440, PMID:26953164).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1999 High

    Established that VAMP7 is a late endosomal/lysosomal SNARE functionally required for endosome-to-lysosome transport, defining its core trafficking role.

    Evidence Antibody inhibition of EGFR degradation in streptolysin-O-permeabilized cells with immunoEM localization to LAMP-1 compartments

    PMID:10459012

    Open questions at the time
    • Did not identify cognate t-SNARE partners
    • No reconstitution of fusion with defined components
  2. 2000 High

    Reconstituted VAMP7 function in cell-free assays and revealed Longin-domain autoinhibition, answering how VAMP7 drives fusion and how it is regulated.

    Evidence Dominant-negative recombinant VAMP7 fragment in cell-free macrophage fusion assays; isolated Longin domain blocking SNAP-25 association and neurite outgrowth in PC12 cells

    PMID:10811829 PMID:10888671

    Open questions at the time
    • Structural basis of Longin autoinhibition not yet defined
    • Physiological trigger for relief of autoinhibition unknown
  3. 2002 High

    Identified the compartment-specific Q-SNARE partners of VAMP7, defining the molecular composition of the late endosomal fusion machinery.

    Evidence Co-IP/MS and reciprocal Co-IP in Dictyostelium and mammalian cells identifying Syntaxin 7/Vti1b/Syntaxin 8; antibody inhibition in rat liver cell-free systems distinguishing VAMP7 vs VAMP8 usage

    PMID:11278762 PMID:12175335 PMID:15133481

    Open questions at the time
    • How partner choice is regulated in cells not resolved
    • Combinatorial logic between VAMP7 and VAMP8 left open
  4. 2004 High

    Extended VAMP7 function to professional secretory and surface-delivery processes, showing it serves multiple regulated exocytic pathways beyond housekeeping fusion.

    Evidence siRNA and dominant-negative Longin-domain perturbations in macrophage phagocytosis and L6 myoblast GLUT4 surface assays

    PMID:15469990 PMID:15470500

    Open questions at the time
    • Distinct vesicle pools not molecularly distinguished
    • Upstream signaling to VAMP7 vesicles unknown
  5. 2008 High

    Defined the structural basis for Longin-domain sorting, showing the clathrin adaptor Hrb recognizes VAMP7 to drive its endocytosis, linking conformational state to trafficking.

    Evidence Crystal structure of Hrb–VAMP7 Longin domain complex with mutagenesis and cell-surface VAMP7 quantification

    PMID:18775314

    Open questions at the time
    • In vivo regulation of Hrb recruitment unaddressed
    • Coupling of cis-SNARE state to retrieval rate not quantified
  6. 2010 High

    Directly demonstrated the closed autoinhibited conformation of VAMP7 in solution, confirming the regulatory model inferred from functional studies.

    Evidence NMR backbone assignment, chemical shift perturbation, and H/D exchange of full-length VAMP7

    PMID:20378544

    Open questions at the time
    • Dynamics of the open–closed transition on membranes not measured
    • Effectors that shift the equilibrium not all defined
  7. 2012 High

    Defined the molecular switches controlling VAMP7 activation and sorting, showing Varp kinetically locks the closed state and AP-3 δ-adaptin reads the SNARE-engaged state for sorting.

    Evidence Crystal structures of Varp-ankyrin–VAMP7 and δ-adaptin-linker–VAMP7 complexes with mutagenesis and in vivo mocha-fibroblast rescue; Co-IP transport-network mapping (Varp/GolginA4/Kif5A/MACF1)

    PMID:22521722 PMID:22705394 PMID:23104059

    Open questions at the time
    • How Varp release is triggered in cells not established
    • Coordination of sorting and motility steps left open
  8. 2013 High

    Identified c-Src phosphorylation of Tyr45 as the activating molecular switch relieving Longin autoinhibition, and extended VAMP7 function to T-cell signaling and TGN-to-endosome LAMP transport.

    Evidence In vitro c-Src kinase assay with Y45E/Y45F mutants and SNARE/exocytosis readouts; VAMP7 KO/siRNA with phospho-Lat biochemistry; siRNA epistasis with hVps41 and immunoEM of LAMP carriers

    PMID:23322049 PMID:23471971 PMID:23666293

    Open questions at the time
    • Upstream signals controlling c-Src–VAMP7 axis in each pathway unresolved
    • How VAMP7 supports vesicle recruitment independent of fusion not fully mechanistic
  9. 2016 High

    Genetic KO mice established selective, non-redundant in vivo roles of VAMP7 in sensory cold detection and β-cell autophagy/insulin secretion, distinguishing physiological pathways from compensable ones.

    Evidence VAMP7 KO and β-cell-specific conditional KO mice with vesicle imaging, electrophysiology, behavior, autophagy flux, and insulin secretion assays

    PMID:21740490 PMID:26843440 PMID:26953164

    Open questions at the time
    • Compensation by other R-SNAREs in unaffected tissues not characterized
    • Tissue-specific SNARE partner usage in vivo not mapped
  10. 2018 Medium

    Resolved how VAMP7 is targeted to specialized destinations, defining ciliary and recycling-endosome targeting complexes and competing regulators of the secretory-lysosome pool.

    Evidence Co-IP mapping of VAMP7 with Rab11/Rab8/Rabin8/FIP3 and Hrb/Syntaxin16/SNAP-47; LRRK1–VARP competition assays with AFM rigidity-sensing readouts

    PMID:30215699 PMID:30240735 PMID:30404838

    Open questions at the time
    • Structural basis of ciliary-complex binding not solved
    • How mechanical cues converge on Longin-domain regulation unclear
  11. 2026 Medium

    Implicated VAMP7-dependent unconventional secretion in organelle stress communication and tumor biology, broadening its role to quality-control signaling.

    Evidence VAMP7 KO glioblastoma secretome proteomics and in vivo rat glioblastoma model

    PMID:41723185

    Open questions at the time
    • Mechanism coupling organellar stress to VAMP7 secretion undefined
    • Identity of the SNARE complex for ER/mitochondrial protein release not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the multiple regulatory inputs (Tyr45 phosphorylation, Varp/LRRK1 competition, mechanical cues, Rab GTPases) are integrated to select among the many VAMP7-dependent fusion pathways in a given cell remains unresolved.
  • No unified model of pathway selection
  • Quantitative contribution of each regulator in vivo unknown
  • Cell-type-specific partner switching not systematically mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 4 GO:0098772 molecular function regulator activity 3 GO:0060089 molecular transducer activity 2
Localization
GO:0005764 lysosome 4 GO:0005886 plasma membrane 4 GO:0031410 cytoplasmic vesicle 4 GO:0005768 endosome 3
Pathway
R-HSA-168256 Immune System 6 R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-9612973 Autophagy 4 R-HSA-1266738 Developmental Biology 3 R-HSA-9609507 Protein localization 3
Partners
AP3D1HRBLRRK1SNAP23STX3STX7VARPVTI1B
Complex memberships
VAMP7–SNAP-23–Syntaxin 4 (invadopodia/mast cell SNARE)VAMP7–Syntaxin 11–SNAP-23 (cytotoxic granule SNARE)VAMP7–Syntaxin 3–SNAP-25 (ciliary/apical SNARE)VAMP7–Syntaxin 7–Vti1b–Syntaxin 8 (late endosome–lysosome SNARE)

Evidence

Reading pass · 56 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 VAMP7 localizes to late endosomes and lysosomes (co-localizing with LAMP-1) and antibodies against its cytoplasmic domain inhibit EGF receptor degradation (endosome-to-lysosome transport) but not transferrin recycling in streptolysin-O-permeabilized cells, establishing a role in vesicular transport from endosomes to lysosomes. Monoclonal/polyclonal antibody generation, immunohistochemistry, immunoelectron microscopy, streptolysin-O permeabilized cell transport assay The Journal of cell biology High 10459012
1999 In neurons, VAMP7/TI-VAMP localizes to a novel membrane compartment distinct from synaptic vesicles and large dense-core granules, concentrating in the leading edge of growth cones before synaptogenesis, suggesting a specialized exocytic vesicle pool for neurite outgrowth. Subcellular fractionation, immunoelectron microscopy, immunofluorescence in hippocampal neurons and PC12 cells The Journal of neuroscience Medium 10559389
2000 VAMP7 is required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages; a soluble dominant-negative VAMP7 fragment (lacking transmembrane domain) inhibited both heterotypic late endosome-lysosome fusion and homotypic lysosome fusion in an in vitro cell-free fusion assay. In vitro cell-free fusion assay with dominant-negative bacterially-expressed VAMP7 fragment Molecular biology of the cell High 10888671
2000 VAMP7/TI-VAMP is essential for vesicular transport mediating neurite outgrowth in staurosporine-differentiated PC12 cells; the N-terminal Longin domain inhibits association with SNAP-25, and expression of this domain blocks neurite outgrowth as potently as Botulinum neurotoxin E (which cleaves SNAP-25), while deletion of the Longin domain increases SNARE complex formation and strongly stimulates neurite outgrowth. Dominant-negative N-terminal domain expression, co-immunoprecipitation of SNARE complexes, neurite outgrowth assay in PC12 cells The Journal of cell biology High 10811829
2000 In RBL-2H3 mast cells, VAMP7 localizes exclusively in granule membranes (not plasma membrane); upon antigen stimulation, VAMP7-positive granules move to the cell surface via fusion with the plasma membrane, suggesting VAMP7 mediates degranulation. RT-PCR, GFP-fusion protein live imaging, confocal microscopy Biochemical and biophysical research communications Medium 10777677
2001 Syntaxin 7 forms SNARE complexes with either VAMP7 or VAMP8 (together with Syntaxin 6 and mVti1b) in B16 melanoma cells, as identified by large-scale Syntaxin 7 immunoprecipitation followed by mass spectrometry, indicating combinatorial SNARE assembly in the late endosomal pathway. Immunoaffinity purification, electrospray mass spectrometry, immunoblotting, immunofluorescence colocalization The Journal of biological chemistry Medium 11278762
2002 In Dictyostelium discoideum, VAMP7 forms an active SNARE complex with Syntaxin 7, Vti1 and Syntaxin 8 in endosomes; co-immunoprecipitation and MS identified these partners, and soluble recombinant VAMP7 fragment inhibited in vitro reconstituted endosome fusion. Co-immunoprecipitation, mass spectrometry peptide sequencing, in vitro endosome fusion assay with recombinant VAMP7 fragment The Biochemical journal High 12175335
2003 Ectopic expression of the plasma membrane t-SNARE syntaxin 1 in the ER redirects TI-VAMP/VAMP7 (and cellubrevin) to the ER in a microtubule-dependent manner, and TI-VAMP associates in vivo with exogenous syntaxin 1, demonstrating that the destination of v-SNAREs is driven by specific interactions with cognate t-SNAREs. Ectopic expression, co-immunoprecipitation, immunofluorescence, microtubule depolymerization Journal of cell science Medium 12759369
2004 The Q-SNAREs syntaxin 7, Vti1b, and syntaxin 8 can pair with either VAMP8 (for homotypic late endosome fusion) or VAMP7 (for heterotypic late endosome–lysosome fusion), as shown by antibody inhibition in rat liver cell-free fusion systems and separate co-immunoprecipitation of syntaxin 7 complexes with VAMP7 or VAMP8. Overexpression of the VAMP7 N-terminal domain in fibroblasts inhibited mixing of lysosomal and late endosomal content markers. Antibody inhibition in rat liver cell-free fusion assay, co-immunoprecipitation, dominant-negative N-terminal domain overexpression, content-mixing assay EMBO reports High 15133481
2004 TI-VAMP/VAMP7 mediates late endocytic compartment exocytosis required for optimal Fc receptor- and complement receptor-mediated phagocytosis in macrophages; dominant-negative Longin domain expression and siRNA depletion of TI-VAMP blocked pseudopod extension and phagosome sealing. Dominant-negative domain expression, siRNA knockdown, scanning electron microscopy, exocytosis assays in macrophages The EMBO journal High 15470500
2004 Hypertonicity-stimulated GLUT4 recruitment to the muscle cell surface is dependent on TI-VAMP/VAMP7 (but not VAMP2), as shown by siRNA knockdown of TI-VAMP reducing basal and hypertonicity-stimulated surface GLUT4; insulin stimulation was only partly reduced, indicating TI-VAMP and VAMP2 mediate GLUT4 trafficking from distinct pools. siRNA knockdown, surface GLUT4myc quantification, dominant-negative NSF expression in L6 myoblasts Molecular biology of the cell Medium 15469990
2005 Cdc42 and F-actin control the polarized accumulation and exocytosis of TI-VAMP/VAMP7-containing vesicles in hippocampal neuron growth cones; dominant-positive Cdc42 stimulates TI-VAMP exocytosis in an actin-dependent manner, as measured by pHLuorin-tagged TI-VAMP fluorescence. Dominant-positive Cdc42 expression, pHLuorin exocytosis assay, actin disruption, immunofluorescence in hippocampal neurons Molecular biology of the cell Medium 16381811
2006 TI-VAMP/VAMP7 is insensitive to botulinum neurotoxin B due to at least 12 amino acid differences from VAMP-2 scattered along a 22-residue interface; replacement of specific residues (including Ile158, Thr161, and section 165-174) with VAMP-2 equivalents progressively restored cleavability. In vitro cleavage assays with chimeric VAMP7/VAMP2 hybrid proteins and point mutants Journal of molecular biology High 16430921
2007 The Longin domain of TI-VAMP/VAMP7 has dual biochemical functions: it inhibits SNARE complex formation and binds to the δ subunit of AP-3, targeting TI-VAMP to late endosomes. Expression of the isolated Longin domain disrupts AP-3δ localization, impairs lysosomal secretion, blocks membrane repair after wounding, and inhibits epithelial cell migration. Inducible Longin domain expression in MDCK cells, immunofluorescence, lysosomal secretion assay, wound healing assay, electron microscopy Biology of the cell Medium 17288539
2007 VAMP7 is required for granzyme B release and target cell killing in NK cell line YT-Indy; siRNA knockdown of VAMP7 reduced granzyme B secretion to <1 ng/mL compared to 1.5-2.5 μg/mL in controls and caused a 7-fold reduction in NK cell-mediated Jurkat killing. siRNA knockdown, granzyme B secretion assay, cytotoxicity assay Biochemical and biophysical research communications Medium 18042464
2008 Clathrin-mediated endocytosis of VAMP7 is directly mediated by the ArfGAP/clathrin adaptor Hrb, which wraps 20 residues of its unstructured C-terminal tail around the VAMP7 longin domain; disrupting this interaction causes VAMP7 accumulation at the cell surface. The VAMP7 SNARE helix can fold back onto the longin domain to compete with Hrb, suggesting Hrb-mediated endocytosis occurs preferentially when VAMP7 is in a cis-SNARE complex. Crystal structure of Hrb-VAMP7 longin domain complex, site-directed mutagenesis, Hrb depletion, cell surface VAMP7 quantification Cell High 18775314
2008 VAMP7 and VAMP8 are required for activation-induced degranulation in primary human mast cells; both SNAREs translocate to the plasma membrane and interact with SNAP-23 and STX-4 upon activation, whereas VAMP2 and VAMP3 knockdown did not inhibit IgE receptor-mediated histamine release. SNARE inhibition (specific approaches), co-immunoprecipitation, histamine release assay, translocation assay in primary human intestinal mast cells European journal of immunology Medium 18253931
2009 VAMP3 mediates fusion of MVBs with autophagosomes to form amphisomes, whereas VAMP7 mediates the subsequent fusion of amphisomes/autophagosomes with lysosomes to complete autophagy. VAMP7 and NSF also participate in MVB fusion with the plasma membrane to release exosomes. siRNA knockdown of VAMP3 or VAMP7 in K562 cells, morphological and biochemical autophagy assays, exosome secretion assay Biochimica et biophysica acta Medium 19781582
2009 TI-VAMP/VAMP7 interacts with Varp (a Rab21 GEF) through a specific interacting domain (ID); Varp, TI-VAMP, and Rab21 co-localize in the perinuclear region and in transport vesicles of differentiating hippocampal neurons. Silencing Varp or expressing the ID or GEF-dead Varp impairs neurite growth, while a GTP-hydrolysis-defective Rab21 mutant enhances it. Co-immunoprecipitation, siRNA knockdown, dominant-negative expression, neurite growth assay, colocalization in hippocampal neurons EMBO reports Medium 19745841
2009 A SNARE complex containing VAMP7 and Vti1a defines a novel non-conventional trafficking pathway to the cell surface used by KChIP1 and Kv4 potassium channels; siRNA knockdown of Vti1a or VAMP7 inhibited Kv4/KChIP1 surface delivery without affecting VSVG conventional trafficking. siRNA knockdown, surface delivery assay, colocalization, comparison with VSVG conventional trafficking The Biochemical journal Medium 19138172
2010 VAMP7/TI-VAMP adopts a preferentially closed conformation in solution, where the SNARE helix folds back onto the longin domain, as established by NMR backbone resonance assignments, chemical shift perturbation analysis, and hydrogen/deuterium exchange experiments. NMR spectroscopy (backbone resonance assignment, chemical shift perturbation, H/D exchange) The Journal of biological chemistry High 20378544
2010 TI-VAMP/VAMP7 depletion enhances clathrin-dependent endocytosis of activated EGFR by reducing cell-surface CD82 (a tetraspanin that controls EGFR microdomain localization); TI-VAMP-positive vesicles transport CD82 from the Golgi to the cell surface, and its loss restrains EGFR diffusion and impairs MAPK signaling. siRNA depletion, quantum dot single-particle tracking, co-immunoprecipitation, Golgi-to-surface secretion assay Journal of cell science Medium 20144992
2011 VAMP7 controls exocytosis of proteolipid protein (PLP) from late endosomal/lysosomal organelles as part of a transcytosis pathway in oligodendrocytes; siRNA silencing and dominant-negative expression reduced PLP at the cell surface and at myelin-like membranes in co-culture with neurons. AP-3δ-deficient mocha mice with VAMP7 missorting show mild dysmyelination with reduced PLP levels. siRNA knockdown, dominant-negative expression, co-culture with cortical neurons, AP-3δ-deficient mouse model analysis The Journal of neuroscience Medium 21490207
2011 VAMP4 and VAMP7 both colocalize with lytic granules in NK cells during cytotoxic interactions; only VAMP7 associates with perforin-containing granules in resting cells. Disruption of either VAMP4 or VAMP7 inhibits lytic granule exocytosis and NK cytotoxic activity, but only VAMP7 is required for IFN-γ secretion. siRNA knockdown in YTS and primary NK cells, cytotoxicity assay, granule exocytosis assay, IFN-γ secretion assay, colocalization European journal of immunology Medium 21805468
2011 VAMP7 knockout mice show reduced neurite outgrowth in cultured hippocampal neurons, but lysosomal exocytosis was not affected in mutant fibroblasts, and apical protein localization in kidney/intestine was normal, demonstrating a selective role in neuronal axon extension. VAMP7 knockout mouse generation, neurite outgrowth assay, lysosomal exocytosis assay, immunohistochemistry in vivo Traffic High 21740490
2012 Varp binds directly to VAMP7, trapping its SNARE motif between Varp's second ankyrin repeat domain and the VAMP7 longin domain, thereby kinetically inhibiting VAMP7 SNARE complex formation; this inhibition is increased when Varp simultaneously binds Rab32-GTP on the same membrane. Crystal structure of Varp ankyrin repeat domain 2 in complex with VAMP7 cytosolic portion, co-immunoprecipitation, SNARE complex formation assay Nature structural & molecular biology High 23104059
2012 Varp interacts with GolginA4 and kinesin 1 (Kif5A), and activated Rab21-GTP binds MACF1, an actin/microtubule regulator that is itself a GolginA4 partner; these components are collectively required for directed anterograde movement of TI-VAMP/VAMP7 vesicles from the cell center to the periphery. Co-immunoprecipitation, siRNA knockdown, live-cell imaging of VAMP7 vesicle dynamics Developmental cell Medium 22705394
2012 TI-VAMP/VAMP7 is the vesicular SNARE that mediates secretory lysosome exocytosis in astrocytes, contributing to ATP and cathepsin B release; downregulation of TI-VAMP inhibited ATP-storing vesicle fusion, ATP-mediated calcium wave propagation, and cathepsin B secretion from glioma cells. siRNA knockdown, live-cell Ca2+ imaging, ATP secretion assay, cathepsin B secretion assay Biology of the cell Medium 22188132
2012 VAMP7 mediates ATP release from autophagic vesicles to the extracellular space; upon starvation, VAMP7-positive/LC3-positive vesicles redistribute to the cell periphery in a microtubule-, KIF5-, and RAB7/RILP-dependent manner and fuse with the plasma membrane to release ATP. siRNA knockdown, colocalization, ATP secretion assay, microtubule depolymerization, live-cell imaging Autophagy Medium 22951367
2012 VAMP7 knockout mice show increased anxiety behavior and decreased brain weight, with increased third ventricle volume; axon growth appeared normal in knockout cultured neurons, suggesting compensatory mechanisms and an unexpected role of TI-VAMP-mediated vesicular traffic in anxiety. Constitutive VAMP7 knockout mouse (exon 3 deletion), behavioral characterization, neuroanatomical analysis, cultured neuron axon growth assay The Journal of neuroscience Medium 22323709
2012 The AP-3 δ-adaptin subunit linker binds the VAMP7 longin domain; the crystal structure shows the interaction requires VAMP7 SNARE motif engagement in a SNARE complex. Mutation of binding residues on either partner abolishes interaction in vitro and in vivo, and abolishes VAMP7 rescue of its mislocalization in mocha (δ-adaptin-null) fibroblasts. Crystal structure of δ-adaptin linker–VAMP7 longin domain complex, site-directed mutagenesis, in vivo mislocalization rescue assay in mocha fibroblasts Developmental cell High 22521722
2013 VAMP7 is required for the recruitment and phosphorylation of Lat-containing vesicles to TCR-activation sites during T cell activation; VAMP7 silencing (by siRNA and in VAMP7-knockout mice) blocked Lat vesicle recruitment without requiring vesicle–plasma membrane fusion, impaired Lat phosphorylation, TCR-Lat signaling complex formation, and T cell activation. siRNA silencing, VAMP7-knockout mice, live-cell imaging, phospho-Lat biochemistry, T cell activation assays Nature immunology High 23666293
2013 Reelin selectively enhances spontaneous (but not evoked) neurotransmitter release via a presynaptic mechanism requiring VAMP7 and SNAP-25 but not synaptobrevin2, VAMP4, or vti1a; the effect requires a modest ApoER2-dependent increase in presynaptic Ca2+. Genetic perturbation (VAMP7 knockout, shRNA knockdown of specific SNAREs), electrophysiology, presynaptic Ca2+ imaging Neuron High 24210904
2013 hVps41 and VAMP7 function in a parallel, direct TGN-to-late endosome transport pathway for LAMP-1 and LAMP-2, distinct from clathrin/M6PR-dependent lysosomal enzyme trafficking; knockdown of hVps41 or VAMP7 caused accumulation of LAMP carriers, while knockdown of hVps39 or hVps18 did not, indicating hVps41 acts independently of CORVET/HOPS. siRNA knockdown, immunoelectron microscopy of endogenous LAMP carriers, LAMP-1-mGFP trafficking assay Nature communications High 23322049
2013 TI-VAMP/VAMP7 exocytosis is activated by c-Src kinase-mediated phosphorylation of tyrosine 45 in the Longin domain; a Y45E phosphomimetic mutant activates both t-SNARE binding and exocytosis, whereas Y45F does not, establishing phosphorylation as a molecular switch relieving Longin domain autoinhibition. In vitro kinase assay with c-Src, site-directed mutagenesis (Y45E and Y45F), SNARE complex formation assay, exocytosis assay The Journal of biological chemistry High 23471971
2014 VAMP7 co-localizes with estrogen receptor α (ESR1) in the presence of 17β-estradiol; elevated VAMP7 levels intensify ESR1-potentiated transcriptional activity by increasing ESR1 protein cellular content upon ligand stimulation, upregulating estrogen-responsive genes (ATF3, CYR61, CTGF) and causing urogenital development defects. Transgenic mouse (human VAMP7 BAC), co-localization experiments, transcriptional reporter assays, gene expression analysis Nature medicine Medium 24880616
2014 SNAP23, Syntaxin4, and VAMP7 form a SNARE complex at invadopodia during tumor cell invasion; coimmunoprecipitation showed increased SNAP23-Syntaxin4-VAMP7 association during invadopodium formation, which correlated with decreased Syntaxin4 phosphorylation. Blocking these SNAREs perturbed MT1-MMP delivery, ECM degradation, and cell invasion. Co-immunoprecipitation, SNARE function blockade, invadopodium ECM degradation assay, invasion assay Molecular biology of the cell Medium 24807903
2015 VAMP7-deficient platelets show partial defects in dense granule and α-granule exocytosis and impaired spreading on matrices; VAMP7 co-immunoprecipitates with VARP and Arp2/3, and these proteins colocalize at the platelet periphery during spreading, suggesting VAMP7 links granule exocytosis with actin reorganization via the VARP–Arp2/3 axis. VAMP7-knockout mouse platelets, granule exocytosis assay, aggregation assay, spreading assay, co-immunoprecipitation of VAMP7–VARP–Arp2/3 Blood High 25999457
2015 Apical exocytosis of NHE3, CFTR, and GLUT5 in polarized epithelial cells requires a cascade involving Rab11, Myo5B, Slp4a, Munc18-2, and Vamp7 with Stx3; CRISPR/genome-edited Myo5B mutation disrupts this pathway selectively, while brush border enzymes localize normally. CRISPR/genome editing of Myo5B in human epithelial cells, cargo-selective exocytosis assay, colocalization and interaction studies The Journal of cell biology Medium 26553929
2015 VAMP7-positive lysosome-like vesicles interact with the Salmonella-containing vacuole (SCV) to promote Salmonella-induced filament formation and bacterial growth within the late SCV, as identified by quantitative proteomics of the SCV at defined time points post-invasion. Quantitative proteomics of isolated SCVs, functional follow-up with VAMP7-positive vesicle interaction assay Cellular microbiology Low 26084942
2016 VAMP7 mediates constitutive transport of TRPM8 channel to the plasma membrane via atypical LAMP1-positive, non-acidic vesicles; VAMP7-deficient mice exhibit reduced TRPM8 functional expression in sensory neurons and concomitant deficits in cold avoidance and icilin-induced cold hypersensitivity. VAMP7-knockout mouse, live-cell imaging of TRPM8 vesicles, patch-clamp electrophysiology, cold avoidance behavioral assay Nature communications High 26843440
2016 VAMP7 regulates autophagy to maintain mitochondrial homeostasis and control glucose-stimulated insulin secretion in pancreatic β-cells; β-cell-specific VAMP7 KO mice show defective autophagosome formation, accumulation of p62 on mitochondria, reduced ATP production, and impaired insulin secretion, which worsens on high-fat diet. β-cell-specific VAMP7 knockout mouse (Vamp7flox/Y;Cre), autophagy flux assay, mitochondrial function assay, glucose-stimulated insulin secretion Diabetes High 26953164
2016 VAMP7-null dendritic cells show impaired multidirectional IL-12 secretion and complete failure of directed IL-12 release at the immune synapse; IL-12 localizes in VAMP7-positive late endocytic vesicles, and VAMP7-mediated release at the immune synapse drives T cell effector function acquisition. VAMP7-knockout mouse DCs, IL-12 secretion assay (ELISA), live-cell imaging of IL-12 vesicles at immune synapse, T cell activation assay Cell reports High 26972013
2016 BLOC-1 regulates formation of tubular transport carriers delivering VAMP7 and TYRP1 cargo to melanosomes, while BLOC-3 (via its exchange factor activity toward RAB38) is required for formation of distinct VAMP7 recycling carriers from melanosomes that also contain VARP; these two pathways explain distinct hypopigmentation phenotypes in BLOC-1 and BLOC-3 deficiency. Live-cell imaging, siRNA knockdown of BLOC-1 and BLOC-3 components, colocalization, VAMP7 trafficking assay in melanocytes The Journal of cell biology Medium 27482051
2017 Vamp7 is associated with Lamp-1+ lysosomal vesicles at the B-cell immune synapse; Vamp7 knockdown impairs local lysosomal secretion at the synapse without affecting lysosome transport to the interface, resulting in defective antigen extraction, processing, and MHC-II presentation. siRNA knockdown, live-cell imaging, lysosome secretion assay at immune synapse, antigen presentation assay Molecular biology of the cell Medium 28179460
2017 Spastin KO in cortical neurons enhances the anterograde velocity of VAMP7-containing vesicles (but not VAMP2 vesicles) via increased acetylated tubulin levels that enhance kinesin-1 motor activity; pharmacological tubulin hyperacetylation recapitulates the VAMP7 axonal dynamics phenotype. SPG4 (spastin) KO neurons, live-cell imaging of VAMP7 and VAMP2 vesicles, tubulin acetylation analysis, pharmacological tubulin stabilization Biochimica et biophysica acta. Molecular basis of disease Medium 28392418
2018 VAMP7 forms a ciliary targeting complex with Rab11 and Rab8 (binding to the VAMP7 longin domain), Rabin8 (interacting with the SNARE domain), and FIP3 (regulating VAMP7 access to Rab11); at the ciliary base, VAMP7 forms a complex with syntaxin 3 and SNAP-25, and the R-SNARE motif of VAMP7 is critical for intracellular trafficking. Co-immunoprecipitation of VAMP7 with Rab11/Rab8/Rabin8/FIP3, transgenic animal expression of VAMP7 mutants (ΔGFP-VAMP7, Y45E, R150E), colocalization with ciliary cargo rhodopsin Journal of cell science Medium 30404838
2018 VAMP7 in pancreatic β-cells localizes in Atg9a-resident vesicles at recycling endosomes and interacts with Hrb, Syntaxin16, and SNAP-47; Hrb recruits VAMP7 and Atg9a from plasma membrane to recycling endosomes, while Syntaxin16/SNAP-47 mediate autophagosome formation, forming a SNARE complex required for autophagy. VAMP7-deficient β-cells, Min6 cell siRNA knockdown, co-immunoprecipitation, colocalization, autophagy assay Endocrinology Medium 30215699
2018 LRRK1 binds the VAMP7 Longin domain and negatively regulates VAMP7-mediated lysosomal secretion; VARP positively controls the peripheral pool of secretory lysosomes; LRRK1 and VARP compete for VAMP7 binding. VAMP7-deficient cells are impaired in adaptation to substrate rigidity, and more rigid substrates stimulate VAMP7-mediated secretion in a Longin domain-dependent manner. Atomic force microscopy, co-immunoprecipitation of VAMP7-LRRK1 and VAMP7-VARP, VAMP7 KO cells, secretion assays on substrates of different rigidity iScience Medium 30240735
2019 VAMP7 forms a SNARE complex with Syntaxin11 and SNAP-23 at the plasma membrane of human cytotoxic T lymphocytes and co-localizes with granule markers throughout T cell maturation; VAMP7 knockdown significantly reduces CTL killing efficiency without impairing early TCR signaling. siRNA knockdown, co-immunoprecipitation, live-cell imaging, cytotoxicity assay in primary human T cells Frontiers in immunology Medium 31447853
2019 DIPK2A, a late endosome/lysosome-localized protein, binds VAMP7B (a SNARE-domain-disrupted isoform of VAMP7), relieving the competitive inhibition VAMP7B exerts on STX17 binding to functional VAMP7A, thereby enhancing autophagosome-lysosome fusion and autophagic degradation. Co-immunoprecipitation, siRNA knockdown, autophagy flux assay, apoptosis assay Autophagy Medium 31251111
2020 VAMP7-dependent secretion of Reticulon 3 (RTN3) regulates neurite growth; VAMP7 KO neuronal secretomes contain less RTN3, expression of the inhibitory VAMP7 Longin domain disrupts RTN3 subcellular localization in neurons, and a nanobody against VAMP7 inhibits axonal overgrowth induced by nutrient restriction, connecting autophagy-related secretion to neurite growth. VAMP7 KO secretome mass spectrometry, Longin domain expression, anti-VAMP7 nanobody, conditioned medium experiments, ATG5 KO Cell reports Medium 33357422
2023 Celastrol directly binds VAMP7 (and RAB7) as confirmed by Surface Plasmon Resonance; overexpression of VAMP7 blocks celastrol's inhibitory effects on autophagosome-lysosome fusion and apoptosis induction in preadipocytes. Surface Plasmon Resonance, overexpression rescue, autophagy flux assay, apoptosis assay Frontiers in pharmacology Medium 36959859
2023 VAMP7j (a human-specific splice isoform lacking the SNARE motif but retaining longin and transmembrane domains) modulates neurite outgrowth in SH-SY5Y cells by mediating L1CAM transport to the plasma membrane in a manner regulated by longin domain phosphorylation. Isoform-specific overexpression, L1CAM surface trafficking assay, phosphomimetic/phospho-null mutations, immunofluorescence International journal of molecular sciences Low 38139155
2023 VAMP7 specifically co-distributes with CCL2-containing granules (but not TNFα- or histamine-containing granules) in bone marrow-derived mast cells, and VAMP7 knockdown markedly reduces CCL2 secretion after antigen stimulation, revealing VAMP7-dependent heterogeneous secretory regulation. siRNA knockdown, immunocytochemistry, confocal microscopy, CCL2 ELISA after antigen stimulation Biochemical and biophysical research communications Medium 38029541
2026 VAMP7 knockout glioblastoma cells show impaired secretion of ER- and mitochondrial-derived proteins and signs of organellar stress; in a preclinical rat glioblastoma model, VAMP7 KO tumors are more necrotic with reduced macrophage infiltration, suggesting VAMP7-dependent late endosomal secretion serves as an organelle quality-control and stress-communication mechanism. VAMP7 KO cell lines, secretome proteomics, organellar stress markers, in vivo rat glioblastoma model, macrophage infiltration analysis Nature communications Medium 41723185

Source papers

Stage 0 corpus · 85 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. Biochimica et biophysica acta 395 19781582
2004 Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events. EMBO reports 219 15133481
2000 Role of tetanus neurotoxin insensitive vesicle-associated membrane protein (TI-VAMP) in vesicular transport mediating neurite outgrowth. The Journal of cell biology 181 10811829
1999 VAMP-7 mediates vesicular transport from endosomes to lysosomes. The Journal of cell biology 166 10459012
2004 TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages. The EMBO journal 151 15470500
2013 hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins. Nature communications 139 23322049
2008 Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb. Cell 127 18775314
2009 Multiple roles of the vesicular-SNARE TI-VAMP in post-Golgi and endosomal trafficking. FEBS letters 117 19837067
2013 Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission. Neuron 111 24210904
2000 Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages. Molecular biology of the cell 105 10888671
2012 A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery. Developmental cell 101 22705394
2011 Phosphorylation of membrane type 1-matrix metalloproteinase (MT1-MMP) and its vesicle-associated membrane protein 7 (VAMP7)-dependent trafficking facilitate cell invasion and migration. The Journal of biological chemistry 101 22002060
2013 VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites. Nature immunology 95 23666293
1999 Subcellular localization of tetanus neurotoxin-insensitive vesicle-associated membrane protein (VAMP)/VAMP7 in neuronal cells: evidence for a novel membrane compartment. The Journal of neuroscience : the official journal of the Society for Neuroscience 92 10559389
2008 Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. European journal of immunology 85 18253931
2015 Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3. The Journal of cell biology 83 26553929
2012 TI-VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes. Biology of the cell 79 22188132
2000 Rat basophilic leukemia cells express syntaxin-3 and VAMP-7 in granule membranes. Biochemical and biophysical research communications 78 10777677
2005 Cdc42 and actin control polarized expression of TI-VAMP vesicles to neuronal growth cones and their fusion with the plasma membrane. Molecular biology of the cell 77 16381811
2012 ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner. Autophagy 76 22951367
2009 Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth. EMBO reports 76 19745841
2001 Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. The Journal of biological chemistry 72 11278762
2016 BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers. The Journal of cell biology 70 27482051
2007 Expression of the Longin domain of TI-VAMP impairs lysosomal secretion and epithelial cell migration. Biology of the cell 68 17288539
2014 SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion. Molecular biology of the cell 67 24807903
2011 Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7. The Journal of neuroscience : the official journal of the Society for Neuroscience 67 21490207
2022 The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis. Cell death & disease 64 35082283
2012 The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation. Nature structural & molecular biology 62 23104059
2010 Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling. Journal of cell science 60 20144992
2012 Absence of TI-VAMP/Vamp7 leads to increased anxiety in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 57 22323709
2004 Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMP. Molecular biology of the cell 52 15469990
2014 Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action. Nature medicine 50 24880616
2019 DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B. Autophagy 47 31251111
2012 Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex. Developmental cell 46 22521722
2022 Role of SNAREs in Unconventional Secretion-Focus on the VAMP7-Dependent Secretion. Frontiers in cell and developmental biology 44 35784483
2002 Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum. The Biochemical journal 43 12175335
2015 The COPII complex and lysosomal VAMP7 determine intracellular Salmonella localization and growth. Cellular microbiology 42 26084942
2002 Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes. Human molecular genetics 42 12444103
2015 VAMP-7 links granule exocytosis to actin reorganization during platelet activation. Blood 41 25999457
2009 A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels. The Biochemical journal 41 19138172
1999 DNA methylation in transcriptional repression of two differentially expressed X-linked genes, GPC3 and SYBL1. Proceedings of the National Academy of Sciences of the United States of America 41 9892682
2016 VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Nature communications 40 26843440
2007 Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line. Biochemical and biophysical research communications 34 18042464
2003 Ectopic expression of syntaxin 1 in the ER redirects TI-VAMP- and cellubrevin-containing vesicles. Journal of cell science 34 12759369
2020 Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth. Cell reports 33 33357422
2011 VAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells. European journal of immunology 33 21805468
2016 The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells. Cell reports 31 26972013
2018 An interaction network between the SNARE VAMP7 and Rab GTPases within a ciliary membrane-targeting complex. Journal of cell science 30 30404838
2016 VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic β-Cells. Diabetes 30 26953164
2011 The role of VAMP7/TI-VAMP in cell polarity and lysosomal exocytosis in vivo. Traffic (Copenhagen, Denmark) 30 21740490
2010 The longin SNARE VAMP7/TI-VAMP adopts a closed conformation. The Journal of biological chemistry 30 20378544
2018 VAMP7 Regulates Autophagosome Formation by Supporting Atg9a Functions in Pancreatic β-Cells From Male Mice. Endocrinology 28 30215699
2018 Biomechanical Control of Lysosomal Secretion Via the VAMP7 Hub: A Tug-of-War between VARP and LRRK1. iScience 28 30240735
2016 Multiple Roles of VARP in Endosomal Trafficking: Rabs, Retromer Components and R-SNARE VAMP7 Meet on VARP. Traffic (Copenhagen, Denmark) 27 27103185
2013 Increased activity of the vesicular soluble N-ethylmaleimide-sensitive factor attachment protein receptor TI-VAMP/VAMP7 by tyrosine phosphorylation in the Longin domain. The Journal of biological chemistry 25 23471971
2019 Cytotoxic Granule Exocytosis From Human Cytotoxic T Lymphocytes Is Mediated by VAMP7. Frontiers in immunology 24 31447853
2017 Vamp-7-dependent secretion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes. Molecular biology of the cell 24 28179460
1997 Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. Human molecular genetics 24 9302271
2006 Identification of the amino acid residues rendering TI-VAMP insensitive toward botulinum neurotoxin B. Journal of molecular biology 21 16430921
2005 Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells. Histochemistry and cell biology 20 16195891
2002 Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder. American journal of medical genetics 19 11840509
2021 Introducing secretory reticulophagy/ER-phagy (SERP), a VAMP7-dependent pathway involved in neurite growth. Autophagy 15 33554711
2017 Spastin regulates VAMP7-containing vesicles trafficking in cortical neurons. Biochimica et biophysica acta. Molecular basis of disease 15 28392418
2014 VAMP7 modulates ciliary biogenesis in kidney cells. PloS one 15 24466086
2008 Sorting of the v-SNARE VAMP7 in Dictyostelium discoideum: a role for more than one Adaptor Protein (AP) complex. Experimental cell research 13 18634783
2023 Celastrol directly binds with VAMP7 and RAB7 to inhibit autophagy and induce apoptosis in preadipocytes. Frontiers in pharmacology 11 36959859
2011 Alternative splicing of the human gene SYBL1 modulates protein domain architecture of Longin VAMP7/TI-VAMP, showing both non-SNARE and synaptobrevin-like isoforms. BMC molecular biology 11 21609427
2020 Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons. Journal of neuroscience research 8 32652719
2018 Zoledronate modulates intracellular vesicle trafficking in mast cells via disturbing the interaction of myosinVa/Rab3a and sytaxin4/VAMP7. Biochemical pharmacology 8 29454616
2017 Drosophila VAMP7 regulates Wingless intracellular trafficking. PloS one 8 29065163
1999 Human and mouse SYBL1 gene structure and expression. Gene 8 10564831
2018 Syntaxin-1/TI-VAMP SNAREs interact with Trk receptors and are required for neurotrophin-dependent outgrowth. Oncotarget 6 30542508
2014 Detection of Turner Syndrome by quantitative PCR of SHOX and VAMP7 genes. Genetic testing and molecular biomarkers 6 25535777
2022 CNV analysis of VAMP7 gene reveals variation associated with growth traits in Chinese cattle. Animal biotechnology 5 35236249
2023 VAMP7 knockdown in secretory granules impairs CCL2 secretion in mast cells. Biochemical and biophysical research communications 3 38029541
2020 Gene Copy Number Quantification of SHOX, VAMP7, and SRY for the Detection of Sex Chromosome Aneuploidies in Neonates. Genetic testing and molecular biomarkers 3 32423256
2019 A case series of infants with increased VAMP7 gene dosage at birth and virilization defects. Journal of pediatric urology 3 32622737
2018 Comparative study of commercially available and homemade anti-VAMP7 antibodies using CRISPR/Cas9-depleted HeLa cells and VAMP7 knockout mice. F1000Research 3 30815249
2025 Basophil-VAMP7 is a vital regulator of skin barrier integrity and chronic itch. The Journal of allergy and clinical immunology 2 40089118
2026 VAMP7-mediated autophagy regulates cervical cancer progression associated with persistent HPV16 infection. Clinical and translational medicine 1 41508736
2025 Neofunctionalization of VAMP7 opened up a plant-unique vacuolar transport pathway. Current biology : CB 1 40367944
2025 Stigmasterol improves diabetic retinopathy by inhibiting VAMP7-mediated autophagy/mitophagy. Biochemical and biophysical research communications 1 40997581
2023 VAMP7j: A Splice Variant of Human VAMP7 That Modulates Neurite Outgrowth by Regulating L1CAM Transport to the Plasma Membrane. International journal of molecular sciences 1 38139155
2026 VAMP7 governs ferroptosis suppression and cisplatin resistance in esophageal cancer: a dual-targeting therapeutic paradigm. Cancer cell international 0 41634691
2026 VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement. Nature communications 0 41723185

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