Affinage

RAB11A

Ras-related protein Rab-11A · UniProt P62491

Length
216 aa
Mass
24.4 kDa
Annotated
2026-04-28
100 papers in source corpus 47 papers cited in narrative 47 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB11A is a small GTPase that serves as a master regulator of membrane recycling, transcytosis, regulated exocytosis, and autophagosome biogenesis from the apical recycling endosome compartment, coordinating cargo delivery in polarized epithelial cells, neurons, endothelial cells, and immune cells (PMID:9880326, PMID:10869360, PMID:29634932). RAB11A recruits effectors including myosin Vb and Rab11-FIP family members to form tripartite complexes that drive actin- and microtubule-dependent vesicular transport of diverse cargoes—ion channels (CFTR, TRPV5, BK channel β1), adhesion molecules (E-cadherin, VE-cadherin), receptors (TLR4, EGFR, GPCRs), polarity determinants (PAR3-aPKC, syntaxin 3), and viral ribonucleoproteins—to appropriate membrane domains (PMID:17462998, PMID:16354700, PMID:20933442, PMID:21525351, PMID:30545898). Its GTPase cycle is regulated by the GAPs TBC1D9B and the C9ORF72-SMCR8-WDR41 complex, by upstream kinase cascades (Cdk5-LMTK1, PI3K-Akt), and by PKC-mediated phosphorylation at Ser177 which directly inhibits RAB11A activity (PMID:25232007, PMID:32303654, PMID:28696251, PMID:24672056). Global Rab11a knockout causes peri-implantation lethality, and intestinal-specific deletion produces microvillus inclusion body-like defects with loss of apical polarity and compromised epithelial barrier integrity, phenocopying features of microvillus inclusion disease (PMID:25271168, PMID:25527643, PMID:34058200).

Mechanistic history

Synthesis pass · year-by-year structured walk · 24 steps
  1. 1998 Medium

    The question of whether RAB11A stays membrane-bound during vesicle fusion was addressed: RAB11A was shown to remain on tubulovesicular membranes throughout fusion with the secretory canaliculus, unlike the canonical Rab GTPase cycle in which GTP hydrolysis triggers membrane dissociation.

    Evidence Subcellular fractionation and immunofluorescence in resting versus histamine-stimulated rabbit parietal cells

    PMID:9688847

    Open questions at the time
    • Single-lab fractionation without independent replication
    • Whether RAB11A membrane retention is general or parietal cell-specific was not tested
  2. 1999 High

    The subcellular site of RAB11A function was established: RAB11A marks an apical pericentriolar recycling endosome compartment accessible from both apical and basolateral surfaces, defining this organelle as the apical recycling endosome and establishing RAB11A as its identity marker.

    Evidence Immunofluorescence, antibody-based internalization, nocodazole perturbation, and IgA trafficking in polarized MDCK cells; parallel identification as the major GTPase on H+/K+-ATPase-containing gastric microsomes

    PMID:10484323 PMID:9880326

    Open questions at the time
    • GEF identity for RAB11A was unknown
    • Mechanism of microtubule dependence was not resolved
  3. 2000 High

    RAB11A's functional specificity for apical recycling and transcytosis—but not basolateral recycling—was demonstrated, distinguishing it from other recycling Rabs.

    Evidence Dominant-negative (S25N) and constitutively active (S20V) RAB11A mutants with IgA transcytosis and transferrin recycling assays in MDCK cells

    PMID:10869360

    Open questions at the time
    • Effector identity mediating pathway specificity was unknown
    • Whether RAB11A functions identically in non-epithelial cells was untested
  4. 2002 High

    The effector mechanism linking RAB11A to cargo transport was identified: myosin Vb was shown to act as a RAB11A effector motor, with disruption of either component blocking receptor recycling from perinuclear endosomes.

    Evidence Dominant-negative RAB11A and myosin Vb tail overexpression with M4 muscarinic receptor recycling assays

    PMID:12427833

    Open questions at the time
    • Whether RAB11A directly activates myosin Vb motor function was unclear
    • Rab11-FIP involvement had not yet been mapped
  5. 2005 High

    RAB11A's role was extended from cargo recycling to de novo organelle biogenesis: the RAB11A–myosin Vb axis was shown to be required for bile canalicular formation, demonstrating that RAB11A controls polarized membrane domain establishment.

    Evidence shRNA knockdown, dominant-negative RAB11A, myosin Vb tail overexpression with canalicular morphogenesis and ABC transporter delivery readouts in WIF-B9 hepatic cells

    PMID:16214890

    Open questions at the time
    • Whether RAB11A acts before or during canalicular membrane expansion was not resolved
  6. 2006 High

    RAB11A was found to directly bind cargo molecules (TRPV5/TRPV6 channels) in its GDP-bound state, revealing an unconventional cargo-recognition mode distinct from effector binding in the GTP-bound state; separately, insulin signaling was shown to activate RAB11A GTP-loading via PI3K/Akt.

    Evidence Co-immunoprecipitation and Ca2+ uptake assays for TRPV5/6; biotinylated GTP-analog incorporation assay with PI3K/Akt inhibitors for insulin signaling

    PMID:16354700 PMID:17158030

    Open questions at the time
    • Structural basis of GDP-state cargo binding was unknown
    • GEF activated downstream of Akt was not identified
  7. 2007 High

    The RAB11A–myosin Vb–cargo complex was validated at the endogenous protein level for CFTR in polarized airway epithelium, and RAB11A was shown to control Langerin recycling and Birbeck granule biogenesis via its effector RCP, extending RAB11A function to immune cell-specific organelles.

    Evidence Endogenous co-immunoprecipitation, RNAi, DN myosin Vb, Cl⁻ secretion assays in airway cells; DN-RAB11A, RCP-KD, and electron microscopy in Langerhans cells

    PMID:17462998 PMID:17538027

    Open questions at the time
    • Whether RCP is the primary effector for all RAB11A-dependent cargoes was untested
  8. 2008 High

    RAB11A was shown to mediate regulated exocytosis (not just constitutive recycling) in bladder umbrella cells, and to serve as a signaling hub at recycling endosomes by recruiting Gβγ-PI3K-Akt complexes upon GPCR activation.

    Evidence Constitutively active and DN RAB11A with surface area and hGH secretion readouts in umbrella cells; Gβγ-RAB11A co-IP with Akt phosphorylation and cell survival assays

    PMID:18701709 PMID:18843107

    Open questions at the time
    • Whether RAB11A-dependent regulated exocytosis requires the same effector set as recycling was unclear
  9. 2009 High

    The tripartite RAB11A–myosin Vb–Rab11-FIP2 complex was defined as a functional unit for cholesterol-regulated NPC1L1 transport, and RAB11A-positive recycling endosomes were implicated in α-synuclein resecretion in neurons.

    Evidence Co-IP, DN mutants, RNAi, and cholesterol uptake assays for NPC1L1; proteomic analysis and pharmacological HSP90 inhibition for α-synuclein resecretion

    PMID:19193894 PMID:19542231

    Open questions at the time
    • Whether HSP90 directly regulates RAB11A GTPase cycle or acts on cargo was unresolved
  10. 2010 High

    RAB11A was shown to control innate immune signaling by trafficking TLR4 to phagosomes, selectively enabling IRF3/interferon-β signaling without affecting NF-κB, revealing pathway-specific immune consequences of RAB11A-dependent receptor delivery.

    Evidence siRNA knockdown of Rab11a with TLR4 phagosome recruitment, IRF3 activation, and IFN-β reporter assays in macrophages

    PMID:20933442

    Open questions at the time
    • Whether RAB11A delivers TLR4 directly or via an intermediate compartment was not resolved
  11. 2011 High

    RAB11A was identified as essential for cytoplasmic transport of influenza A virus vRNPs to the plasma membrane, establishing RAB11A as a host factor co-opted by a major pathogen for genome trafficking.

    Evidence siRNA, DN, and CA RAB11A with vRNP localization and co-IP in infected cells

    PMID:21525351

    Open questions at the time
    • Whether vRNP binding competes with endogenous RAB11A effectors was unknown
  12. 2012 High

    Spatiotemporal resolution of the RAB11A–myosin Vb–FIP2 complex showed it operates at two distinct sites: vesicle formation at the ERC and docking/fusion at the plasma membrane, defining a two-step mechanism for cargo delivery.

    Evidence Live-FRET, fast FRAP, TIRF microscopy of complex dynamics with langerin cargo

    PMID:22420646

    Open questions at the time
    • What triggers complex disassembly after fusion was not determined
  13. 2013 High

    RAB11A was placed upstream of RAB8A in a Rab cascade for regulated exocytosis via Rabin8, and Reggie-1/Flotillin-2 was identified as a direct partner regulating RAB11A association with tubular recycling structures.

    Evidence Epistasis with DN/CA Rabs and catalytically inactive Rabin8 in umbrella cells; co-IP, KD, and rescue with CA-Rab11a for Reggie-1 in epithelial cells

    PMID:23389633 PMID:23825023

    Open questions at the time
    • How Rabin8 promotes exocytosis independently of its GEF catalytic activity was unexplained
  14. 2014 High

    In vivo studies established that RAB11A is essential for mammalian viability and intestinal epithelial polarity: global KO causes peri-implantation lethality, intestinal-specific KO produces microvillus inclusions resembling microvillus inclusion disease, and the RAB11A–MYO5B interaction (not RAB8A–MYO5B) prevents inclusion formation; mechanistically, RAB11A–myosin Vb was shown to control ezrin phosphorylation and microvilli formation.

    Evidence Global and conditional KO mice; MYO5B-P660L MVID mutant expression; Rab-binding domain mutants; phospho-ezrin detection in enterocyte models and patient tissue

    PMID:24413175 PMID:24892806 PMID:25271168 PMID:25527643

    Open questions at the time
    • Whether RAB11A directly recruits ezrin kinases or controls their substrate access was unresolved
  15. 2014 High

    A complete upstream signaling cascade was defined: Cdk5 phosphorylates LMTK1, which controls RAB11A-positive endosome dynamics (velocity, run-length, prevalence) to regulate dendrite outgrowth, identifying kinase-mediated regulation of RAB11A transport in neurons.

    Evidence LMTK1-KO neurons, S34A phospho-mutant, live imaging of RAB11A-positive endosome dynamics

    PMID:24672056

    Open questions at the time
    • Direct LMTK1 substrate linking to RAB11A regulation was not identified at this point
  16. 2014 High

    The first RAB11A-specific GAP (TBC1D9B) was identified biochemically, providing direct evidence for how RAB11A GTP hydrolysis is catalyzed in vivo and how transcytosis rates are controlled.

    Evidence In vitro GTPase assay with purified proteins showing Rab11a specificity; gain/loss-of-function in transcytosis assays in MDCK cells

    PMID:25232007

    Open questions at the time
    • Whether TBC1D9B is the sole physiological GAP for RAB11A was unknown
  17. 2015 High

    RAB11A function was extended to endothelial barrier maintenance: VE-cadherin directly engages Rab11-FIP2 to form a ternary complex with RAB11A, and in vivo RAB11A knockdown increases vascular leakage, linking recycling endosome dysfunction to vascular permeability.

    Evidence Y2H, co-IP, calcium-switch assay, surface biotinylation, in vivo lung Rab11a-KD with vascular leakage readout

    PMID:26663395

    Open questions at the time
    • Whether RAB11A loss affects endothelial polarity broadly or specifically VE-cadherin recycling was not fully dissected
  18. 2017 High

    Post-translational control of RAB11A was defined: PKC phosphorylates RAB11A at Ser177, inhibiting its activity and reducing surface delivery of BK channel β1 subunits, providing the first direct mechanism for acute, stimulus-dependent RAB11A inactivation.

    Evidence Phospho-specific mutants (S177A, S177D), PKC inhibitors, single-channel recordings, myography in cerebral arteries

    PMID:28696251

    Open questions at the time
    • Whether Ser177 phosphorylation affects all RAB11A effector interactions equally was untested
  19. 2018 High

    RAB11A-positive recycling endosomes were identified as the primary membrane source for autophagosome biogenesis: WIPI2 localizes to autophagosome precursors by binding RAB11A in conjunction with PI3P generated on these membranes, directly linking recycling endosome identity to autophagy initiation.

    Evidence RAB11A KO/KD, WIPI2-RAB11A binding assays, PI3P detection, autophagy flux for transferrin receptor and mitophagy, live imaging

    PMID:29634932

    Open questions at the time
    • Whether RAB11A provides membrane or acts as a signal for autophagosome nucleation was not distinguished
  20. 2019 High

    The Cdk5-LMTK1 pathway was mechanistically completed: TBC1D9B was identified as the LMTK1-binding protein that transduces kinase signaling into RAB11A GAP activity, defining a full Cdk5→LMTK1→TBC1D9B→RAB11A cascade controlling dendritic spine formation; separately, in vitro reconstitution showed RAB11A binding directly relieves myosin Vb autoinhibition, activating its motor.

    Evidence Y2H, co-IP, TBC1D9B-KD in neurons for spine density; purified-protein ATPase and binding assays for Myo5b activation

    PMID:30545898 PMID:31628178

    Open questions at the time
    • Whether LMTK1 directly phosphorylates TBC1D9B or acts indirectly was not shown
    • Whether RAB11A-activated Myo5b requires FIP2 for processive movement in vivo was unclear
  21. 2020 High

    A second GAP complex for RAB11A was structurally and biochemically defined: the C9ORF72-SMCR8-WDR41 complex catalyzes GTP hydrolysis on RAB11A (and RAB8A) via an arginine finger (SMCR8 Arg147), linking ALS/FTD-associated C9ORF72 biology to RAB11A regulation.

    Evidence Cryo-EM at 3.2 Å, in vitro GTPase assays, Arg147 mutagenesis

    PMID:32303654

    Open questions at the time
    • Physiological context in which C9ORF72 complex preferentially acts on RAB11A versus RAB8A was undefined
  22. 2021 High

    RAB11A was shown to control influenza genome packaging by providing a vesicular platform for selective congregation of all 8 vRNP segments via vRNP:vRNP interactions, and RAB11A was found to regulate YAP junctional localization and epithelial integrity in vivo.

    Evidence Rab11a-deficient cells with vRNA FISH and packaging fidelity measurements; conditional RAB11A-KO mice with YAP localization and co-IP of junctional complexes

    PMID:33970958 PMID:34058200

    Open questions at the time
    • Whether RAB11A passively provides a concentration platform or actively sorts vRNPs was not distinguished
    • Whether YAP mislocalization is a direct or indirect consequence of junctional cargo mistrafficking was unclear
  23. 2022 High

    The molecular basis of IAV vRNP hijacking of RAB11A was resolved: PB2 polymerase subunit C-terminal domain directly binds RAB11A at the same switch I region used by Rab11-FIPs, establishing competitive displacement of host effectors as the mechanism of viral co-option.

    Evidence In vitro direct binding, SAXS structural analysis, switch I mutagenesis

    PMID:35019720

    Open questions at the time
    • Whether therapeutic disruption of PB2-RAB11A interaction is feasible was not tested
  24. 2023 High

    RAB11A and RAB11B were shown to redundantly control mitotic spindle formation via shared interactors including kinesin KIF11, and accessory ESCRT-III proteins were identified as selectively required for ILV formation in RAB11A-positive recycling endosomes (RAB11A-exosome biogenesis).

    Evidence Double conditional KO mice and enteroids with spindle analysis and proteomics; comparative proteomics and CHMP5 knockdown for exosome biogenesis

    PMID:36872252 PMID:37424454

    Open questions at the time
    • Whether RAB11A directly recruits KIF11 or acts through intermediaries was not determined
    • Whether ESCRT-III selectivity for RAB11A-exosomes extends to all cell types was untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the identity of the primary GEF for RAB11A, the structural basis for its unconventional GDP-state cargo binding, how Ser177 phosphorylation selectively modulates specific effector interactions, and whether RAB11A's mitotic spindle role is mechanistically linked to its membrane trafficking function.
  • No GEF for RAB11A has been identified
  • No high-resolution structure of RAB11A bound to a cargo in the GDP state exists
  • Relationship between membrane trafficking and mitotic spindle functions is unclear

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 3 GO:0060090 molecular adaptor activity 3 GO:0008092 cytoskeletal protein binding 1
Localization
GO:0005768 endosome 4 GO:0031410 cytoplasmic vesicle 4 GO:0005856 cytoskeleton 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 7 R-HSA-1500931 Cell-Cell communication 3 R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 2 R-HSA-1640170 Cell Cycle 1 R-HSA-9612973 Autophagy 1
Partners
FLOT2HTTLMTK1MYO5BRAB11FIP2RAB8ASMCR8TBC1D9B
Complex memberships
C9ORF72-SMCR8-WDR41RAB11A-MYO5B-RAB11FIP2

Evidence

Reading pass · 47 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 RAB11A localizes to an apical pericentriolar endosomal compartment (apical recycling endosome) in polarized MDCK epithelial cells, and this compartment is accessible to membrane markers internalized from either apical or basolateral poles, functionally defining it as the apical recycling endosome; integrity of this compartment depends on intact microtubules. Immunofluorescence, antibody labeling, nocodazole treatment, dimeric IgA trafficking assay in MDCK cells Molecular biology of the cell High 9880326
2000 A dominant-negative GTP-binding-deficient RAB11A mutant (Rab11aS25N) inhibits both apical recycling and basolateral-to-apical transcytosis of IgA but does not inhibit basolateral recycling of transferrin in polarized MDCK cells, placing RAB11A specifically in the apical recycling/transcytotic pathway. Inducible expression of wild-type, dominant-negative (S25N), and constitutively active (S20V) RAB11A mutants; IgA and transferrin trafficking assays in MDCK cells The Journal of biological chemistry High 10869360
1999 RAB11A is the predominant GTPase associated with H+/K+-ATPase-enriched gastric microsomes (stoichiometry ~1 Rab11a per 6 H+/K+-ATPase), and expression of dominant-negative Rab11a N124I in parietal cells blocks histamine-stimulated recruitment of H+/K+-ATPase to the apical plasma membrane. Mass spectrometry identification; adenoviral expression of dominant-negative Rab11a N124I; aminopyrine uptake assay; immunocytochemistry in primary rabbit parietal cell cultures The American journal of physiology High 10484323
1998 RAB11A remains associated with H+/K+-ATPase-containing tubulovesicle membranes during fusion with the secretory canaliculus upon histamine stimulation and redistributes to apical canalicular membranes without cycling off into the soluble fraction, indicating RAB11A stays membrane-bound during recycling vesicle fusion. Subcellular fractionation, immunofluorescence, Western blot of resting and stimulated rabbit parietal cells The American journal of physiology Medium 9688847
2005 RAB11A and myosin Vb are required for bile canalicular formation in hepatic WIF-B9 cells; knockdown of Rab11a or expression of GDP-locked Rab11a, or overexpression of a motorless myosin Vb tail domain, each prevents canalicular formation and blocks delivery of apical ABC transporters to the plasma membrane. shRNA knockdown, dominant-negative overexpression, immunofluorescence, live-cell imaging in WIF-B9 hepatic epithelial cells Proceedings of the National Academy of Sciences of the United States of America High 16214890
2002 RAB11A and its effector myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor; dominant-negative Rab11aS25N blocks M4 trafficking to recycling endosomes, and expression of the myosin Vb C-terminal tail enhances M4 accumulation in perinuclear endosomes and impairs M4 recycling to the cell surface. Dominant-negative RAB11A and myosin Vb tail overexpression; receptor trafficking assays; colocalization with transferrin receptor and Rab11a markers in cell culture The Journal of neuroscience High 12427833
2006 RAB11A directly and specifically interacts with the GDP-bound form of itself to bind the carboxyl terminus of epithelial Ca2+ channels TRPV5 and TRPV6; coexpression of GDP-locked RAB11A with TRPV5 or TRPV6 reduces channel plasma membrane abundance and Ca2+ uptake, demonstrating RAB11A traffics these channels to the apical membrane via direct cargo interaction in the GDP-bound state. Co-immunoprecipitation, colocalization, dominant-negative GDP-locked RAB11A expression, Ca2+ uptake assay in epithelial cells Molecular and cellular biology High 16354700
2007 RAB11A regulates CFTR recycling in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells; endogenous CFTR forms a complex with endogenous myosin Vb and Rab11a, and silencing myosin Vb or expressing a myosin Vb tail fragment (whose dominant-negative effect requires the ability to interact with RAB11A) decreases apical CFTR and Cl- secretion. Co-immunoprecipitation of endogenous proteins, RNAi knockdown, dominant-negative myosin Vb tail fragment, CFTR Cl- secretion assay in polarized airway epithelial cells The Journal of biological chemistry High 17462998
2009 RAB11A and heat shock protein HSP90 interact; rab11a regulates resecretion of extracellular alpha-synuclein in neurons (recycling endosome-mediated pathway), and HSP90 inhibitor geldanamycin prevents resecretion and attenuates neurotoxicity. Quantitative proteomic analysis, co-immunoprecipitation of Rab11a and HSP90, pharmacological inhibition of HSP90, resecretion assay in neurons The Journal of neuroscience Medium 19193894
2010 RAB11A controls trafficking of TLR4 from the endocytic recycling compartment (ERC) to E. coli phagosomes; RAB11A silencing reduces TLR4 on phagosomes, inhibits IRF3 signaling pathway (interferon-β induction) induced by E. coli, and reduces TRAM on phagosomes, without affecting NF-κB activation. siRNA knockdown of Rab11a; confocal colocalization; TLR4/TRAM phagosome recruitment assay; IRF3 activation and IFN-β reporter assays in macrophages Immunity High 20933442
2011 RAB11A is indispensable for transport of influenza A virus vRNPs to the plasma membrane; RAB11A associates with vRNPs throughout cytoplasmic transport and forms a complex with vRNPs biochemically; siRNA depletion or dominant-negative/constitutively active RAB11A expression causes aberrant vRNP accumulation in the perinuclear region and prevents plasma membrane delivery. siRNA knockdown, dominant-negative and constitutively active RAB11A overexpression, immunofluorescence, co-immunoprecipitation of RAB11A with vRNPs Journal of virology High 21525351
2018 RAB11A-positive recycling endosome membranes serve as the primary platform for autophagosome assembly; WIPI2 localizes to autophagosome precursors by binding RAB11A in concert with PI3P formed on RAB11A-positive membranes upon starvation; loss of RAB11A impairs recruitment of autophagic machinery and autophagy of the transferrin receptor and damaged mitochondria. RAB11A knockout/knockdown, WIPI2-RAB11A co-localization and binding assays, PI3P detection on RAB11A membranes, autophagy flux assays (transferrin receptor, mitophagy), live imaging Developmental cell High 29634932
2014 TBC1D9B functions as a GTPase-activating protein (GAP) for RAB11A in polarized MDCK cells; TBC1D9B interacts with RAB11A in a nucleotide-dependent manner, specifically stimulates GTP hydrolysis by RAB11A (not Rab11b or Rab4a at physiological Mg2+), colocalizes with Rab11a-positive recycling endosomes, and its overexpression (but not inactive mutant) decreases basolateral-to-apical IgA transcytosis while shRNA depletion increases this Rab11a-dependent pathway. GTPase activity assay (in vitro with purified proteins), co-immunoprecipitation, shRNA knockdown, overexpression of WT and catalytically inactive TBC1D9B, IgA transcytosis assay, active Rab11a pull-down Molecular biology of the cell High 25232007
2009 RAB11A forms a tripartite complex with myosin Vb and Rab11-FIP2; the myosin Vb·RAB11A·Rab11-FIP2 complex is required for cholesterol-regulated translocation of NPC1L1 from the endocytic recycling compartment to the plasma membrane; dominant-negative mutants of any component inhibit NPC1L1 export and decrease cellular cholesterol uptake. Dominant-negative mutant expression, RNAi, co-immunoprecipitation, cholesterol uptake assay, NPC1L1 surface trafficking assay The Journal of biological chemistry High 19542231
2014 RAB11A deficiency in intestinal epithelial cells causes accumulation of apical proteins in cytoplasm and mislocalisation to basolateral membranes, shortened microvilli and microvillus inclusion bodies; RAB8A is mislocalised in Rab11a-KO mice and vice versa, demonstrating a functional interdependence between RAB11A, RAB8A, and myosin Vb in intestinal apical polarity. Conditional intestinal Rab11a-knockout mice; immunofluorescence; electron microscopy; complementary analysis of Rab8a-KO mice and myosin Vb mutant patient tissue Biology open High 25527643
2013 RAB11A directly interacts with Reggie-1/Flotillin-2 at the tubulovesicular recycling compartment; knockdown of reggie-1 reduces association of Rab11a with tubular structures and impairs transferrin receptor recycling and E-cadherin recycling; these defects are rescued by constitutively active Rab11a, placing Reggie-1 as a regulator of the RAB11A-dependent recycling pathway. Co-immunoprecipitation (direct interaction of Reggie-1 with Rab11a), shRNA knockdown, constitutively active Rab11a rescue, calcium-switch E-cadherin recycling assay, transferrin recycling assay Molecular biology of the cell High 23825023
2014 RAB11A and myosin Vb regulate phosphorylation of ezrin at T567 in enterocytes; dominant-negative Rab11a or myosin Vb depletion prevents subapical enrichment of Rab11a, co-distributing ezrin kinases, and inhibits ezrin phosphorylation and microvilli development, suggesting RAB11A-positive recycling endosomes serve as signaling platforms for ezrin activation. Dominant-negative Rab11a expression, myosin Vb RNAi, immunofluorescence, phospho-ezrin (T567) detection in enterocyte models and microvillus inclusion disease patient samples Journal of cell science High 24413175
2014 MYO5B uncoupling from RAB11A (but not RAB8A) induces formation of microvillus inclusions; the RAB11A-MYO5B interaction is required for preventing microvillus inclusion formation in enterocytes, while the RAB8A-MYO5B interaction is required for microvilli establishment. Stable MYO5B knockdown in CaCo2-BBE cells; expression of MVID-associated MYO5B-P660L mutant; surface biotinylation; dual immunofluorescence; expression of RAB-binding domain mutants The Journal of clinical investigation High 24892806
2014 Global Rab11a knockout in mice causes peri-implantation lethality; Rab11a vesicular trafficking is required for secretion of multiple soluble matrix metalloproteinases (MMPs) from embryonic fibroblasts. Global Rab11a-null mice; multiple cargo trafficking assays including MMP secretion assays; complementation analysis in Rab11a-null MEFs The Journal of biological chemistry High 25271168
2014 RAB11A-positive endosome trafficking is controlled by LMTK1 in neurons; LMTK1 knockout increases prevalence, velocity, and run length of anterograde Rab11A-positive endosomes, promoting dendrite growth; a non-phosphorylatable LMTK1 mutant (Ser34Ala, a Cdk5 phosphorylation site) dramatically promotes dendritic formation, indicating a Cdk5-LMTK1-RAB11A pathway regulates dendritic development. LMTK1 knockout neurons; live imaging of RAB11A-positive endosome dynamics; LMTK1 Ser34Ala mutant expression; in vivo and in vitro dendrite morphometry Molecular biology of the cell High 24672056
2019 TBC1D9B, a RAB11A GAP, is a LMTK1-binding protein; LMTK1 controls the GAP activity of TBC1D9B on RAB11A; TBC1D9B mediates LMTK1 activity on RAB11A to regulate dendritic spine formation, defining a Cdk5-LMTK1-TBC1D9B-RAB11A cascade. Yeast two-hybrid, co-immunoprecipitation; TBC1D9B knockdown in primary neurons; spine density morphometry; in vitro kinase assays The Journal of neuroscience High 31628178
2015 RAB11A mediates VE-cadherin recycling and controls endothelial barrier function; VE-cadherin directly interacts with Rab11-FIP2 (at aa 453-484) forming a ternary complex with RAB11A; silencing RAB11A or Rab11-FIP2 prevents VE-cadherin recycling and its plasma membrane expression, blocks junctional reannealing after inflammation, and in vivo RAB11A knockdown in pulmonary microvessels increases vascular leakage. Yeast two-hybrid, co-immunoprecipitation, calcium-switch assay, cell surface biotinylation, flow cytometry, RNAi, in vivo Rab11a knockdown in mouse lung Arteriosclerosis, thrombosis, and vascular biology High 26663395
2015 RAB11A regulates apical localization of syntaxin 3 in enterocytes; Rab11a deficiency (conditional KO or stable KD in CaCo2-BBE cells) alters syntaxin 3 apical localization, shortens microvillar length, and causes lateral membrane microvilli formation. Conditional intestinal Rab11a-KO mice, stable Rab11a-KD CaCo2-BBE cells, immunofluorescence for syntaxin 3 and apical markers Journal of cell science High 25673875
2015 Huntingtin (HTT) forms a complex with PAR3, aPKC, and RAB11A and ensures microtubule-dependent apical vesicular transport of PAR3-aPKC through RAB11A, establishing epithelial polarity during mammary morphogenesis. Co-immunoprecipitation (HTT with PAR3, aPKC, RAB11A), conditional HTT depletion in mammary epithelium in vivo, live imaging of vesicular transport, dominant-negative RAB11A rescue experiments PLoS biology High 25942483
2017 Endothelin-1 stimulates PKC-mediated phosphorylation of RAB11A at serine 177, which inhibits RAB11A activity and reduces RAB11A-dependent surface trafficking of BK channel β1 subunits in arterial smooth muscle cells, leading to BK channel inhibition and vasoconstriction; expression of phosphorylation-incapable Rab11A S177A blocks the ET-1 effect. PKC inhibitors, phosphorylation-incapable (S177A) and phosphomimetic RAB11A mutants, surface protein quantification, single BK channel recordings, myography for vasoconstriction in cerebral arteries Circulation research High 28696251
2020 The C9ORF72-SMCR8-WDR41 complex functions as a GTPase-activating protein (GAP) for RAB8A and RAB11A; cryo-EM structure at 3.2 Å reveals that Arg147 of SMCR8 is the arginine finger critical for stimulating GTP hydrolysis by Rab8a and Rab11a. Cryo-EM structure determination (3.2 Å); biochemical GTPase activity assays; site-directed mutagenesis of Arg147; structural comparison with FLCN-FNIP2 GAP complex Proceedings of the National Academy of Sciences of the United States of America High 32303654
2008 RAB11A directly interacts with the carboxyl-terminal tail of the human prostacyclin receptor (hIP); this interaction was mapped to Val299-Gln320 of the hIP C-tail and is augmented by agonist stimulation; overexpression of RAB11A increases hIP recycling to the plasma membrane, while dominant-negative Rab11a S25N impairs it. Yeast two-hybrid screen, co-immunoprecipitation in HEK293 and endothelial cells, dominant-negative/wild-type overexpression, receptor recycling assay Cellular signalling High 18832025
2007 RAB11A controls the biogenesis of Birbeck granules (BGs) by regulating Langerin recycling and stability; dominant-negative Rab11A or Rab11A depletion missorts Langerin to lysosomes and blocks BG formation; loss of RCP (a Rab11A effector) also modestly affects Langerin stability and BG biogenesis, indicating a RAB11A-RCP complex mediates these events. Dominant-negative Rab11A overexpression, Rab11A siRNA knockdown, RCP knockdown, immunofluorescence tracking of Langerin, electron microscopy for BG biogenesis Molecular biology of the cell High 17538027
2008 RAB11A undergoes agonist-dependent regulated exocytosis of discoidal/fusiform vesicles (DFVs) in bladder umbrella cells; constitutively active Rab11a stimulates increased apical surface area without stretch, while dominant-negative Rab11a inhibits stretch-induced exocytosis; secretory cargo (hGH) is packaged into Rab11a-positive DFVs and its release depends on Rab11a activity. Adenoviral delivery of dominant-active and dominant-negative Rab11a mutants in situ; apical surface area measurements; hGH secretion assay; fluid and membrane endocytosis tracers Proceedings of the National Academy of Sciences of the United States of America High 18843107
2013 RAB11A acts upstream of RAB8A to promote stretch-induced exocytosis of DFVs in bladder umbrella cells; Rabin8 (a Rab11A effector and GEF for Rab8) stimulates exocytosis independently of its catalytic activity; myosin 5B works with the Rab8a-Rab11a module to promote DFV transit through the subapical actin cytoskeleton before fusion. Dominant-negative and constitutively active Rab GTPase expression, catalytically inactive Rabin8 expression, dominant-negative myosin 5B tail, exocytosis quantification in umbrella cells Molecular biology of the cell High 23389633
2008 Gβγ subunits interact with RAB11A and colocalize at recycling endosomes in response to LPA receptor activation; this Gβγ-RAB11A interaction recruits PI3K and promotes AKT phosphorylation at endosomal compartments; dominant-negative RAB11A or wortmannin (PI3K inhibitor) attenuates LPA-induced AKT activation and cell survival/proliferation. Co-immunoprecipitation (Gβγ with Rab11a), confocal colocalization, dominant-negative Rab11a expression, wortmannin treatment, AKT phosphorylation assay, RNAi depletion of Rab11a Molecular biology of the cell High 18701709
2006 RAB11A regulates EGFR recycling; transfection of RAB11A accelerates EGFR recycling while dominant-negative Rab11aS25N postpones EGFR recycling in MCF10A breast cells; dominant-negative RAB11A inhibits EGF-stimulated proliferation and anchorage-dependent colonization but increases cell motility toward EGFR ligands. Iodinated ligand:receptor recycling assay, dominant-negative RAB11A transfection, proliferation and motility assays, ERK1/2 and AKT signaling assays Breast cancer research and treatment Medium 16791477
2009 RAB11A-positive recycling endosomes regulate apoptotic cell death signaling by diverting recycling endosome trafficking to the Golgi apparatus via a pathway involving Src-family kinases, Cdc42, and Rab11a; inhibition of this pathway blocks Golgi fragmentation and caspase-independent cell death progression. E4orf4 model, pharmacological inhibition of SFKs and Cdc42, dominant-negative Rab11a, live-cell imaging of Golgi dynamics, cell death assays Molecular biology of the cell Medium 19641023
2006 Insulin stimulates transient GTP-loading of RAB11A in cardiomyocytes in a PI3-kinase- and Akt-dependent manner (2.3-fold activation peaking at 4 min), identifying RAB11A as a direct element of the insulin-regulated GLUT4 trafficking machinery. Biotinylated GTP-analog incorporation assay in H9c2-hIR cells expressing HA-tagged Rab11a, PI3K inhibitor treatment, Akt RNAi knockdown Cellular signalling Medium 17158030
2014 The RAB11A tripartite complex with Rab11-FIP2 and MYO5B requires specific residues (S229 and G233 in FIP2) for FIP2-MYO5B interaction; mutation of these residues or Rab11-FIP2 knockdown increases speed and track length of RAB11A-containing vesicle movement, consistent with impaired MYO5B tethering at the cytoskeleton. Random mutagenesis of Rab11-FIP2, yeast two-hybrid, co-immunoprecipitation, live-cell imaging of Rab11a vesicle movement in HeLa and MDCK cells Traffic (Copenhagen, Denmark) High 24372966
2012 The MYO5B/RAB11A/Rab11-FIP2 complex platform operates at two distinct spatial sites in live cells: first at the ERC sorting site where transport vesicles form, and subsequently at the docking/tethering/fusion stage at the plasma membrane, as demonstrated for langerin cargo trafficking. Live-FRET, fast FRAP video, fast confocal, and TIRF microscopy of MYO5B/Rab11A/Rab11-FIP2 complex dynamics in live cells with langerin as cargo Traffic (Copenhagen, Denmark) High 22420646
2019 RAB11A binding to the globular tail domain (GTD) of Myosin-5b abolishes the head-GTD autoinhibitory interaction of Myo5b, thereby activating its motor function; FIP2 bridges Myo5b and membrane-bound RAB11A (with higher affinity for FIP2 than for Myo5b), with FIP2 binding not affecting Myo5b motor activity. In vitro binding and ATPase assays with purified proteins; affinity measurements for Rab11a-FIP2 and Rab11a-Myo5b interactions Bioscience reports High 30545898
2016 RAB11A is essential for lamellar body biogenesis in the human epidermis; Rab11a silencing in 3D reconstructed human epidermis reduces lamellar body density and secretion, misdirects lamellar body cargoes to the lysosomal degradation pathway, and causes an epidermal barrier defect. Rab11a siRNA in 3D reconstructed human epidermis, electron microscopy, immunofluorescence, barrier function assay, lipid quantification in stratum corneum The Journal of investigative dermatology High 26872604
2017 RAB11A inactivation in macrophages facilitates efferocytosis of apoptotic neutrophils by increasing surface CD36; Rab11a knockdown increases surface CD36 and decreases surface ADAM17, while overexpression of wild-type Rab11a inhibits efferocytosis; ADAM17 depletion rescues the decreased CD36 in cells overexpressing wild-type Rab11a, placing RAB11A upstream of ADAM17-mediated surface expression of CD36. siRNA knockdown, wild-type and dominant-negative Rab11a overexpression, ADAM17 depletion, CD36 surface flow cytometry, efferocytosis assays, in vivo intratracheal Rab11a-KD macrophage instillation Journal of immunology High 28053235
2018 RAB11A-Rab8a acts in a cascade to regulate formation of tunneling nanotubes (TNTs); overexpression of Rab11a and Rab8a increases TNT-connected cells and vesicle propagation between cells; RAB11A activates Rab8a independently of the GEF Rabin8; VAMP3 acts downstream of Rab8a in TNT formation. Dominant-negative and constitutively active Rab GTPase expression, RNAi knockdown, live-cell imaging of vesicle transfer, epistasis analysis with catalytically inactive Rabin8 Journal of cell science High 30209134
2017 RAB11A controls disruption of Rab8a and Rab11a double-KO mice causes basolateral microvillus formation; inducible Rab11a deletion from neonatal enterocytes alone is sufficient to induce basolateral microvilli within 3 days; distinct apical cargoes require either individual or both Rab8a and Rab11a for apical transport. Enterocyte-specific Rab8a/Rab11a double and single conditional KO mice; inducible Rab11a deletion; immunofluorescence; electron microscopy Journal of cell science High 28596241
2021 RAB11A-positive vesicles serve as hubs for congregation of influenza A virus vRNP complexes enabling specific genome assembly through vRNP:vRNP interactions; in Rab11a-deficient cells, vRNP bundles are smaller with less co-localization between distinct vRNA segments and more non-infectious particles are produced, indicating RAB11A promotes selective packaging of all 8 genome segments. Rab11a-deficient cells (CRISPR/siRNA), fluorescence microscopy with tetracysteine-tagged NP vRNP reporter, vRNA FISH, PFU/genome ratio measurements PLoS pathogens High 33970958
2022 The C-terminal domains of the PB2 polymerase subunit of influenza A virus directly interact with RAB11A in solution at 1:1 stoichiometry, mediating vRNP association with RAB11A; the switch I region of RAB11A important for Rab11-FIP binding is also required for PB2-C binding, suggesting IAV polymerase and Rab11-FIPs compete for the same RAB11A binding site. Pulldown assays from infected cell lysates, in vitro direct binding assays, SAXS structural analysis of PB2-C/RAB11A complex, site-directed mutagenesis of RAB11A switch I region Journal of virology High 35019720
2021 RAB11A controls YAP localization to adherens and tight junctions in intestinal epithelial cells; RAB11A controls biochemical associations of YAP with α-catenin, β-catenin, and Merlin; loss of RAB11A leads to nuclear accumulation of YAP and enhanced YAP-β-catenin complex formation, and RAB11A-deficient mice show reduced epithelial integrity after chemical injury. Conditional RAB11A-KO mice; co-immunoprecipitation of YAP with junctional components; immunofluorescence; chemical injury colitis model The Journal of biological chemistry High 34058200
2023 RAB11A and RAB11B redundantly control mitotic spindle function in intestinal progenitor cells; double (but not single) KO of Rab11a and Rab11b causes mitotic arrest and apoptosis with abnormal mitotic spindle formation; proteomic profiling of Rab11a/Rab11b immunoprecipitates reveals a shared interactome of mitotic spindle microtubule regulators; disrupting Rab11 impairs kinesin KIF11 function and bipolar spindle formation. Single and double conditional KO mice; ex vivo enteroids; untargeted proteomics of RAB11A/B immunoprecipitates; mitotic spindle immunofluorescence; kinesin KIF11 functional assays EMBO reports High 37424454
2013 FLCN (Birt-Hogg-Dubé protein) binds to RAB11A through its C-terminal DENN-like domain and promotes loading of the amino acid transporter PAT1 onto RAB11A vesicles for plasma membrane targeting; suppression of either RAB11A or FLCN re-routes PAT1 to lysosomes and down-regulates mTORC1. Co-immunoprecipitation, FLCN and Rab11a siRNA knockdown, in vitro GEF activity assay (FLCN does not act as GEF for Rab11a), cargo trafficking assay for PAT1, mTORC1 activity measurement Journal of cell science Medium 30446510
2023 Accessory ESCRT-III proteins (CHMP1A, CHMP1B, CHMP5, IST1) are selectively required for formation of ILVs in RAB11A-positive recycling endosomes (Rab11a-exosomes) but are not involved in degradation of ubiquitinylated proteins in late endosomes; CHMP5 knockdown in human HCT116 cells selectively inhibits RAB11A-exosome production. Comparative proteomics of human small EVs, Drosophila secondary cell genetics, CHMP5 knockdown in HCT116 cells, EVsecretion assay, ubiquitin-protein degradation assay Journal of extracellular vesicles High 36872252

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Molecular biology of the cell 345 9880326
2000 Regulation of vesicle trafficking in madin-darby canine kidney cells by Rab11a and Rab25. The Journal of biological chemistry 195 10869360
2018 The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A. Developmental cell 175 29634932
2010 The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity 174 20933442
2011 RAB11A is essential for transport of the influenza virus genome to the plasma membrane. Journal of virology 154 21525351
2005 Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells. Proceedings of the National Academy of Sciences of the United States of America 129 16214890
2009 Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein. The Journal of neuroscience : the official journal of the Society for Neuroscience 118 19193894
2002 Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience 111 12427833
2009 Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis. PLoS pathogens 95 19165333
2006 Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane. Molecular and cellular biology 95 16354700
2007 Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. The Journal of biological chemistry 91 17462998
2014 Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease. The Journal of clinical investigation 90 24892806
1999 Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. The American journal of physiology 84 10484323
2003 Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells. Experimental cell research 82 14567990
2019 Exosomes from MiR-21-5p-Increased Neurons Play a Role in Neuroprotection by Suppressing Rab11a-Mediated Neuronal Autophagy In Vitro After Traumatic Brain Injury. Medical science monitor : international medical journal of experimental and clinical research 80 30860987
2014 Rab11a is required for apical protein localisation in the intestine. Biology open 79 25527643
1998 Rab11a redistributes to apical secretory canaliculus during stimulation of gastric parietal cells. The American journal of physiology 75 9688847
2013 Reggies/flotillins interact with Rab11a and SNX4 at the tubulovesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking. Molecular biology of the cell 65 23825023
2008 Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proceedings of the National Academy of Sciences of the United States of America 65 18843107
2013 Rab11-family interacting proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling system. Molecular biology of the cell 63 23283983
2015 MiR-21 inhibits autophagy by targeting Rab11a in renal ischemia/reperfusion. Experimental cell research 61 26302266
2020 Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a. Proceedings of the National Academy of Sciences of the United States of America 60 32303654
2015 Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier Function. Arteriosclerosis, thrombosis, and vascular biology 60 26663395
2003 Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2. American journal of physiology. Cell physiology 59 12540381
2015 MicroRNA-320a inhibits proliferation and invasion of breast cancer cells by targeting RAB11A. American journal of cancer research 58 26609479
2009 Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. The Journal of biological chemistry 57 19542231
2023 Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation. Journal of extracellular vesicles 56 36872252
2015 Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes. Journal of cell science 56 25673875
2014 Rab11-FIP2 interaction with MYO5B regulates movement of Rab11a-containing recycling vesicles. Traffic (Copenhagen, Denmark) 56 24372966
2008 G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction. Molecular biology of the cell 56 18701709
2013 A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells. Molecular biology of the cell 53 23389633
2006 Rab11a differentially modulates epidermal growth factor-induced proliferation and motility in immortal breast cells. Breast cancer research and treatment 49 16791477
2017 Rab11a promotes proliferation and invasion through regulation of YAP in non-small cell lung cancer. Oncotarget 45 28468127
2014 Myosin Vb and Rab11a regulate phosphorylation of ezrin in enterocytes. Journal of cell science 44 24413175
2008 Tomato Rab11a characterization evidenced a difference between SYP121-dependent and SYP122-dependent exocytosis. Plant & cell physiology 44 18385165
2018 Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 43 30048990
2020 Long non-coding RNA NORAD contributes to the proliferation, invasion and EMT progression of prostate cancer via the miR-30a-5p/RAB11A/WNT/β-catenin pathway. Cancer cell international 42 33292272
2016 Rab11a sustains GSK3β/Wnt/β-catenin signaling to enhance cancer progression in pancreatic cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 42 27481517
2005 c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis. The American journal of pathology 41 15972968
2018 Rab11a-Rab8a cascade regulates the formation of tunneling nanotubes through vesicle recycling. Journal of cell science 40 30209134
2014 The lipid kinase PI4KIIIβ is highly expressed in breast tumors and activates Akt in cooperation with Rab11a. Molecular cancer research : MCR 40 24962317
2014 TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells. Molecular biology of the cell 40 25232007
2012 A Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane. Traffic (Copenhagen, Denmark) 40 22420646
2013 Intracellular transport of the measles virus ribonucleoprotein complex is mediated by Rab11A-positive recycling endosomes and drives virus release from the apical membrane of polarized epithelial cells. Journal of virology 39 23408617
2014 Global ablation of the mouse Rab11a gene impairs early embryogenesis and matrix metalloproteinase secretion. The Journal of biological chemistry 38 25271168
2017 Inactivation of Rab11a GTPase in Macrophages Facilitates Phagocytosis of Apoptotic Neutrophils. Journal of immunology (Baltimore, Md. : 1950) 37 28053235
2015 Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC. PLoS biology 37 25942483
2017 Intracellular Colocalization of Influenza Viral RNA and Rab11A Is Dependent upon Microtubule Filaments. Journal of virology 36 28724771
2007 Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism. Molecular endocrinology (Baltimore, Md.) 36 17426287
2020 Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association. Nature communications 35 31911620
2015 Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins. The Journal of biological chemistry 32 26635365
2020 Rab11A regulates dense granule transport and secretion during Toxoplasma gondii invasion of host cells and parasite replication. PLoS pathogens 31 32463830
2016 Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors. PloS one 31 27529348
2021 Rab11a mediates cell-cell spread and reassortment of influenza A virus genomes via tunneling nanotubes. PLoS pathogens 30 34473799
2016 Reggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons. Experimental neurology 30 27993509
2007 Rab11A controls the biogenesis of Birbeck granules by regulating Langerin recycling and stability. Molecular biology of the cell 30 17538027
2014 LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes. Molecular biology of the cell 29 24672056
2013 A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases. The Journal of biological chemistry 29 24302731
2008 Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase. Cellular signalling 29 18832025
2019 The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience 28 31628178
2017 Endothelin-1 Stimulates Vasoconstriction Through Rab11A Serine 177 Phosphorylation. Circulation research 28 28696251
2015 Reggie-1/Flotillin-2 regulates integrin trafficking and focal adhesion turnover via Rab11a. European journal of cell biology 28 26299802
2015 Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses. Virology 28 26484934
2009 Regulation of cell death by recycling endosomes and golgi membrane dynamics via a pathway involving Src-family kinases, Cdc42 and Rab11a. Molecular biology of the cell 27 19641023
2017 Tumor-suppressive microRNA-452 inhibits migration and invasion of breast cancer cells by directly targeting RAB11A. Oncology letters 26 28781694
2016 Rab11a Is Essential for Lamellar Body Biogenesis in the Human Epidermis. The Journal of investigative dermatology 26 26872604
2016 Rab8a/Rab11a regulate intercellular communications between neural cells via tunneling nanotubes. Cell death & disease 26 28005071
2020 Rab11a regulates MMP2 expression by activating the PI3K/AKT pathway in human hepatocellular carcinoma cells. Pathology, research and practice 25 32825931
2017 Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy. Journal of cell science 25 28596241
2021 Host factor Rab11a is critical for efficient assembly of influenza A virus genomic segments. PLoS pathogens 24 33970958
2007 FIP2 and Rip11 specify Rab11a-mediated cellular distribution of GLUT4 and FAT/CD36 in H9c2-hIR cells. Biochemical and biophysical research communications 24 17854769
2021 Exocyst controls exosome biogenesis via Rab11a. Molecular therapy. Nucleic acids 23 35036064
2021 RAB11A-mediated YAP localization to adherens and tight junctions is essential for colonic epithelial integrity. The Journal of biological chemistry 22 34058200
2011 Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells. Experimental cell research 22 22036648
2007 The JNK/AP-1 pathway upregulates expression of the recycling endosome rab11a gene in B cells transformed by Theileria. Cellular microbiology 22 17388783
2019 Rab11a drives adhesion molecules to the surface of endometrial epithelial cells. Human reproduction (Oxford, England) 21 30597006
2017 Rab11a is required for porcine reproductive and respiratory syndrome virus induced autophagy to promote viral replication. Biochemical and biophysical research communications 21 28822762
2013 GRAB is a binding partner for the Rab11a and Rab11b GTPases. Biochemical and biophysical research communications 21 24140058
2020 Rab11A Functions as a Negative Regulator of Osteoclastogenesis through Dictating Lysosome-Induced Proteolysis of c-fms and RANK Surface Receptors. Cells 19 33142674
2020 Rab11a Is Overexpressed in Gastric Cancer and Regulates FAK/AKT Signaling. Journal of oncology 19 33178272
2011 A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. Journal of cell science 18 21984810
2019 Regulation of Myosin-5b by Rab11a and the Rab11 family interacting protein 2. Bioscience reports 17 30545898
2018 Influenza A Virus NS1 Protein Suppresses JNK1-Dependent Autophagosome Formation Mediated by Rab11a Recycling Endosomes. Frontiers in microbiology 16 30619194
2017 MiR-150 Inhibits Cell Growth In Vitro and In Vivo by Restraining the RAB11A/WNT/β-Catenin Pathway in Thyroid Cancer. Medical science monitor : international medical journal of experimental and clinical research 16 29023429
2013 Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo. American journal of physiology. Cell physiology 16 24153428
2014 Nucleotide bound to rab11a controls localization in rod cells but not interaction with rhodopsin. The Journal of neuroscience : the official journal of the Society for Neuroscience 15 25378153
2022 The C-Terminal Domains of the PB2 Subunit of the Influenza A Virus RNA Polymerase Directly Interact with Cellular GTPase Rab11a. Journal of virology 14 35019720
2006 A novel method to monitor insulin-stimulated GTP-loading of Rab11a in cardiomyocytes. Cellular signalling 14 17158030
2023 RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells. EMBO reports 13 37424454
2020 RAB11A mediates the proliferation and motility of esophageal cancer cells via WNT signaling pathway. Acta biochimica Polonica 13 33326197
2014 Distinct patterns of phosphatidylserine localization within the Rab11a-containing recycling system. Cellular logistics 13 25210648
2023 CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids. Stem cell reports 12 37541258
2022 RAB11A Expression Is Associated With Cancer Aggressiveness Through Regulation of FGFR-Signaling in Lung Squamous Cell Carcinoma. Annals of surgical oncology 12 35644860
2024 CircRAB11A act as miR-24-5p sponge promotes proliferation and resists apoptosis of chicken granulosa cell via EGFR/ERK1/2 and RAB11A/ PI3K/AKT pathways. Poultry science 11 38806000
2010 Rab11a and its binding partners regulate the recycling of the ß1-adrenergic receptor. Cellular signalling 11 20727405
2024 Stress-induced Rab11a-exosomes induce amphiregulin-mediated cetuximab resistance in colorectal cancer. Journal of extracellular vesicles 10 38887984
2018 FLCN is a novel Rab11A-interacting protein that is involved in the Rab11A-mediated recycling transport. Journal of cell science 10 30446510
2022 Rab11a promotes the malignant progression of ovarian cancer by inducing autophagy. Genes & genomics 9 36125654
2013 The PDZ-interaction of the intestinal anion exchanger downregulated in adenoma (DRA; SLC26A3) facilitates its movement into Rab11a-positive recycling endosomes. American journal of physiology. Gastrointestinal and liver physiology 9 23578788
1995 The evolutionary relationships between homologs of ribosomal YL8 protein and YL8-like proteins. Current genetics 9 8536309