Affinage

RAB11A

Ras-related protein Rab-11A · UniProt P62491

Length
216 aa
Mass
24.4 kDa
Annotated
2026-06-10
100 papers in source corpus 51 papers cited in narrative 51 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB11A is a small GTPase that organizes a microtubule-dependent apical/endocytic recycling endosome compartment and, in its GTP-bound state, directs the slow recycling and transcytosis of membrane cargoes to the correct plasma-membrane domain (PMID:9880326, PMID:10869360). Its central effector module is the myosin Vb/Rab11-FIP2 complex: RAB11A binding to the myosin Vb globular tail relieves motor autoinhibition while FIP2 bridges the motor to RAB11A on vesicles, with the FIPs further subdividing the recycling system into kinetically distinct subdomains (PMID:30545898, PMID:23283983, PMID:24372966). Through this machinery RAB11A controls polarized delivery of a broad cargo set—H+/K+-ATPase, CFTR, TRPV5/6, NPC1L1, VE-cadherin, syntaxin 3, GPCRs, and the PAR3-aPKC polarity complex—and is required in vivo for apical membrane identity, microvillus assembly, and ezrin phosphorylation in intestinal epithelium (PMID:10484323, PMID:17462998, PMID:16354700, PMID:19542231, PMID:26663395, PMID:25673875, PMID:25942483, PMID:24413175). RAB11A acts upstream of RAB8A in a cascade governing regulated exocytosis, apical polarity, and tunneling-nanotube formation, and the two paralogs redundantly support mitotic spindle bipolarity via KIF11 (PMID:23389633, PMID:25527643, PMID:28596241, PMID:30209134). Beyond recycling, RAB11A-positive membranes nucleate autophagosome biogenesis by recruiting WIPI2 and generating PI3P, and support a distinct class of exosomes formed by accessory ESCRT-III proteins (PMID:29634932, PMID:36872252). The GTPase cycle is set by GAPs—TBC1D9B (acting downstream of an LMTK1 cascade) and the C9ORF72-SMCR8-WDR41 complex whose SMCR8 Arg147 arginine finger drives hydrolysis—and by activating insulin/PI3K-Akt signaling and inhibitory PKC phosphorylation at Ser177 (PMID:25232007, PMID:31628178, PMID:32303654, PMID:17158030, PMID:28696251). Multiple RNA viruses including influenza A and measles hijack RAB11A to transport viral ribonucleoproteins to the plasma membrane, with influenza PB2 binding the RAB11A switch I region to compete directly with Rab11-FIPs (PMID:21525351, PMID:23408617, PMID:35019720).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1999 High

    Defined RAB11A's compartment: established that RAB11A marks a microtubule-dependent apical recycling endosome accessible to cargo from both poles, giving the protein a physical address.

    Evidence Immunofluorescence, nocodazole microtubule disruption, and IgA trafficking in polarized MDCK cells

    PMID:9880326

    Open questions at the time
    • Did not define which cargoes obligately pass through this compartment
    • GTPase cycle requirements not yet dissected
  2. 2000 High

    Linked the GTPase cycle to pathway specificity: showed nucleotide-state mutants selectively block apical recycling and transcytosis but not basolateral recycling, defining RAB11A as a pathway-specific regulator.

    Evidence Inducible dominant-negative (S25N) and constitutively active (S20V) mutants with IgA transcytosis and transferrin recycling assays

    PMID:10869360

    Open questions at the time
    • Effectors mediating apical specificity not identified
    • Molecular basis of cargo discrimination unknown
  3. 2007 High

    Identified the core effector module and demonstrated cargo control: established that an endogenous RAB11A/myosin Vb/Rab11-FIP complex recycles physiological cargoes (H+/K+-ATPase, CFTR, TRPV5/6, GPCRs) to the apical surface with functional output.

    Evidence Co-IP of endogenous complexes, dominant-negative and effector-tail mutants, surface biotinylation, Ca2+ uptake and Cl- secretion electrophysiology across parietal, airway, and renal cell models

    PMID:10484323 PMID:12427833 PMID:16354700 PMID:17462998 PMID:18832025

    Open questions at the time
    • Mechanism of cargo selection by individual FIPs not resolved
    • Single-cell-type studies for several cargoes
  4. 2014 Medium

    Resolved the recycling machinery into subdomains and a tethering/motor mechanism: showed FIPs partition the system temporally and that FIP2 tethers MYO5B to RAB11A vesicles, controlling vesicle dynamics.

    Evidence Live-cell deconvolution kinetics of FIP compartments and mutagenesis mapping FIP2-MYO5B interaction with vesicle tracking

    PMID:23283983 PMID:24372966

    Open questions at the time
    • How FIPs achieve cargo specificity within subdomains unresolved
    • In vivo relevance of subdomain ordering untested
  5. 2014 High

    Established RAB11A's in vivo requirement for epithelial polarity and the RAB11A-RAB8A-MYO5B axis: conditional and global knockouts revealed apical cargo mislocalization, microvillus inclusion disease-like phenotypes, and reciprocal RAB11A-RAB8A dependence.

    Evidence Intestine-specific and global RAB11A knockout mice, single/double RAB11A-RAB8A knockouts, MYO5B patient mutation analysis, MMP secretion and ezrin phosphorylation assays

    PMID:24413175 PMID:24892806 PMID:25271168 PMID:25527643 PMID:25673875 PMID:28596241

    Open questions at the time
    • Precise cargo sets uniquely versus redundantly handled by RAB8A still being delineated
    • Mechanism coupling trafficking to microvillus inclusion formation incompletely defined
  6. 2017 High

    Defined the regulatory inputs controlling RAB11A activity: identified TBC1D9B and the C9ORF72-SMCR8-WDR41 complex as GAPs, the LMTK1 cascade as their controller, insulin/PI3K-Akt as an activating input, and PKC-Ser177 phosphorylation as an inhibitory PTM.

    Evidence In vitro GAP assays, cryo-EM of SMCR8 with Arg147 arginine-finger mutagenesis, GTP-loading assays under insulin/PI3K-Akt inhibition, and a phosphorylation-incapable S177A mutant with electrophysiology and vasoreactivity readouts

    PMID:17158030 PMID:25232007 PMID:28696251 PMID:31628178 PMID:32303654

    Open questions at the time
    • GEF(s) that load GTP onto RAB11A not definitively identified (FLCN explicitly lacks GEF activity)
    • Crosstalk between phosphorylation and GAP regulation unmapped
  7. 2018 High

    Expanded RAB11A's role beyond recycling to autophagosome and exosome biogenesis: showed RAB11A membranes recruit WIPI2 and generate PI3P to nucleate autophagy and use accessory ESCRT-III for a distinct exosome class.

    Evidence RAB11A knockout/knockdown with WIPI2 binding, PI3P detection, LC3 lipidation assays, and comparative proteomics plus CHMP5 knockdown ILV/exosome assays

    PMID:29634932 PMID:36872252

    Open questions at the time
    • How RAB11A membranes are selected as autophagy platforms versus recycling carriers unclear
    • Cargo selectivity of RAB11A-derived exosomes unknown
  8. 2022 High

    Established the structural basis of viral hijacking: showed influenza PB2 binds the RAB11A switch I region in a 1:1 complex, directly competing with Rab11-FIPs to commandeer the recycling machinery for vRNP transport and genome assembly.

    Evidence Pulldown, SAXS solution structure, domain mapping, and live-imaging/siRNA studies of vRNP transport, TNT spread, and genome bundling across influenza and measles models

    PMID:21525351 PMID:23408617 PMID:31911620 PMID:33970958 PMID:34473799 PMID:35019720

    Open questions at the time
    • Whether host motor/adaptor swapping is general across viruses untested
    • Therapeutic exploitation of the PB2-switch I interface unexplored
  9. 2023 High

    Revealed a recycling-independent mitotic function and paralog redundancy: RAB11A/RAB11B double-knockout disrupts bipolar spindle formation via KIF11, with lethal cell-cycle arrest.

    Evidence Double-knockout mice, enteroid culture, unbiased IP proteomics, and KIF11 functional/spindle imaging analysis

    PMID:37424454

    Open questions at the time
    • Whether RAB11A acts as a vesicular platform or directly on spindle microtubules unresolved
    • Functional non-redundancy of RAB11A versus RAB11B for spindle role undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • The GEF(s) responsible for physiological GTP-loading of RAB11A and the structural rules by which a single GTPase compartment is partitioned among recycling, autophagy, exosome, and spindle functions remain unresolved.
  • No validated RAB11A GEF identified in the corpus (FLCN lacks GEF activity)
  • Molecular switch directing RAB11A membranes to distinct downstream fates unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 3 GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005768 endosome 3 GO:0005886 plasma membrane 3 GO:0031410 cytoplasmic vesicle 3 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-1643685 Disease 3 R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-9609507 Protein localization 3 R-HSA-1640170 Cell Cycle 1 R-HSA-9612973 Autophagy 1
Partners
KIF11MYO5BPB2RAB11FIP2RAB8ASMCR8TBC1D9BWIPI2
Complex memberships
C9ORF72-SMCR8-WDR41 GAP complexRAB11A/myosin Vb/Rab11-FIP2 recycling complex

Evidence

Reading pass · 51 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 RAB11A localizes to an apical pericentriolar endosomal compartment in MDCK epithelial cells that is dependent on intact microtubules for its integrity; this compartment is accessible to membrane-bound markers internalized from either apical or basolateral poles, functionally defining it as the apical recycling endosome. Immunofluorescence, nocodazole treatment, dimeric IgA trafficking assay Molecular biology of the cell High 9880326
2000 A dominant-negative GTP-binding-deficient RAB11A mutant (Rab11aS25N) potently inhibits both transcytosis and apical recycling of IgA but not basolateral transferrin recycling in polarized MDCK cells; conversely, GTPase-deficient RAB11A (S20V) inhibits basolateral-to-apical transcytosis but not recycling. This defines RAB11A's GTPase cycle as essential specifically for apical recycling and transcytotic pathways. Inducible expression of dominant-negative and constitutively active RAB11A mutants, IgA transcytosis assay, transferrin recycling assay The Journal of biological chemistry High 10869360
1999 RAB11A is associated with H+/K+-ATPase-enriched gastric microsomes at a stoichiometry of approximately one RAB11A per six H+/K+-ATPase copies; expression of dominant-negative RAB11A N124I in primary parietal cells inhibits histamine-stimulated recruitment of H+/K+-ATPase to the apical membrane. Mass spectrometry co-fractionation, adenoviral dominant-negative expression, aminopyrine uptake assay, immunocytochemistry The American journal of physiology High 10484323
1998 RAB11A redistributes to the apical secretory canaliculus during histamine stimulation of gastric parietal cells but does not dissociate into soluble fractions during vesicle fusion, indicating it remains membrane-associated through the tubulovesicle–canaliculus fusion cycle. Subcellular fractionation, immunofluorescence of resting vs. stimulated parietal cells The American journal of physiology Medium 9688847
2002 After agonist-induced internalization, the M4 muscarinic acetylcholine receptor (M4 mAChR) traffics to transferrin receptor- and RAB11A-positive perinuclear recycling endosomes; dominant-negative RAB11A (S25N) inhibits M4 recycling to the cell surface, and expression of the myosin Vb C-terminal tail (a RAB11A effector) enhances M4 accumulation in perinuclear endosomes and impairs recycling. Fluorescence co-localization, dominant-negative RAB11A expression, myosin Vb tail overexpression, receptor recycling assay The Journal of neuroscience Medium 12427833
2005 RAB11A and myosin Vb are required for bile canalicular formation in polarized hepatic WIF-B9 cells; knockdown of RAB11A or expression of GDP-locked RAB11A prevents canalicular formation, as does overexpression of the myosin Vb motorless tail domain. siRNA knockdown, dominant-negative overexpression, confocal imaging, polarized hepatic cell model Proceedings of the National Academy of Sciences of the United States of America High 16214890
2006 RAB11A directly interacts with TRPV5 and TRPV6 Ca2+ channels in the GDP-bound conformation, co-localizing in vesicular structures beneath the apical plasma membrane; co-expression of GDP-locked RAB11A reduces cell surface expression and Ca2+ uptake of these channels. Co-immunoprecipitation, yeast-two-hybrid, Ca2+ uptake assay, dominant-negative RAB11A co-expression Molecular and cellular biology Medium 16354700
2007 RAB11A co-localizes with CFTR in apical recycling endosomes in polarized human airway epithelial cells; endogenous CFTR forms a complex with endogenous myosin Vb and RAB11A; myosin Vb silencing or expression of a dominant myosin Vb tail fragment (which requires RAB11A interaction to exert its effect) decreases CFTR apical membrane expression and reduces Cl− secretion. Co-immunoprecipitation of endogenous proteins, siRNA knockdown of myosin Vb, dominant-negative myosin Vb tail fragment expression, electrophysiology (Cl− secretion assay), surface biotinylation The Journal of biological chemistry High 17462998
2007 RAB11A controls biogenesis of Birbeck granules in Langerhans cells by regulating Langerin trafficking and stability; dominant-negative RAB11A or RAB11A depletion causes missorting of Langerin to lysosomes and abolishes Birbeck granule formation; loss of the RAB11A effector RCP (but not Rip11) also modestly impairs this process, suggesting RAB11A-RCP complexes mediate Langerin recycling. Dominant-negative RAB11A overexpression, siRNA depletion of RAB11A and Rab11-FIPs, electron microscopy, fluorescence microscopy Molecular biology of the cell Medium 17538027
2008 RAB11A directly interacts with the C-terminal tail of the human prostacyclin receptor (hIP) via a defined 22-amino-acid sequence (Val299-Gln320); this interaction is augmented by agonist stimulation; overexpression of RAB11A increases hIP recycling to the plasma membrane, whereas dominant-negative RAB11A (S25N) impairs recycling. Yeast-two-hybrid screen, co-immunoprecipitation in HEK293 cells, dominant-negative RAB11A overexpression, fluorescence co-localization, deletion mapping Cellular signalling Medium 18832025
2008 Gβγ subunits interact with RAB11A and co-localize at early and recycling endosomes upon LPA receptor activation; this RAB11A-dependent association promotes PI3K recruitment and AKT phosphorylation at endosomal compartments; dominant-negative RAB11A or RAB11A depletion attenuates LPA-dependent AKT activation and cell survival. Co-immunoprecipitation, co-localization, dominant-negative RAB11A expression, siRNA knockdown, AKT phosphorylation assay Molecular biology of the cell Medium 18701709
2008 RAB11A is expressed in bladder umbrella cells where it associates with discoidal/fusiform vesicles (DFV); dominant-active RAB11A stimulates apical surface area increase and hGH secretion in the absence of stretch, while dominant-negative RAB11A inhibits stretch-induced exocytosis; endocytosed fluid and membrane markers have little access to RAB11A-positive DFV, suggesting DFV are biosynthetic. Adenovirus-mediated dominant-active/dominant-negative RAB11A expression in situ, surface area measurement, secretory marker (hGH) packaging/release assay Proceedings of the National Academy of Sciences of the United States of America Medium 18843107
2009 RAB11A is required for completion of cytokinesis in Toxoplasma gondii-related apicomplexan parasites; RAB11A associates with Myosin-Tail-Interacting-Protein (MTIP/MLC1), a component of the glideosome motor complex; ablation of RAB11A function results in an incompletely formed Inner Membrane Complex and a block at a late stage of cell division. Co-immunoprecipitation (RAB11A-MTIP interaction), dominant-negative RAB11A expression, electron microscopy of IMC formation, conditional knockout PLoS pathogens Medium 19165333
2009 RAB11A regulates recycling of extracellular alpha-synuclein from neurons; proteomic analysis of RAB11A-associated proteins identified HSP90, which was validated as a RAB11A-interacting protein; HSP90 inhibition with geldanamycin prevents re-secretion of alpha-synuclein. Quantitative proteomics of RAB11A-associated proteins, co-immunoprecipitation of RAB11A-HSP90, alpha-synuclein secretion assay, pharmacological inhibition The Journal of neuroscience Medium 19193894
2009 Myosin Vb, RAB11A, and Rab11-FIP2 form a required triple complex for cholesterol-depletion-induced transport of NPC1L1 from the endocytic recycling compartment to the plasma membrane; inactivation of any component of this complex inhibits NPC1L1 export and reduces cellular cholesterol uptake. Dominant-negative mutant expression of myosin Vb, RAB11A, and Rab11-FIP2; fluorescence microscopy; cholesterol uptake assay The Journal of biological chemistry Medium 19542231
2010 RAB11A controls TLR4 trafficking from the endocytic recycling compartment to E. coli phagosomes; suppression of RAB11A reduces TLR4 and TRAM on phagosomes, inhibiting the IRF3 signaling pathway (IFN-β induction) while NF-κB activation is unaffected. siRNA knockdown, co-localization studies, interferon-β reporter assay, NF-κB activity assay Immunity High 20933442
2011 RAB11A is indispensable for transport of influenza A vRNPs to the plasma membrane; RAB11A associates with vRNPs at all stages of cytoplasmic transport; siRNA knockdown or expression of dominant-negative/constitutively active RAB11A mutants causes aberrant vRNP perinuclear retention and prevents plasma membrane accumulation; RAB11A-vRNP complex formation was confirmed biochemically. siRNA knockdown, dominant-negative/constitutively active RAB11A expression, immunofluorescence, biochemical co-precipitation of RAB11A-vRNP complex Journal of virology High 21525351
2012 A RAB11A/Myosin Vb/Rab11-FIP2 platform regulates langerin recycling at two distinct intracellular sites: first at the sorting site in the endosomal recycling compartment (ERC) where transport vesicles are formed, and subsequently at the docking/tethering and fusion step at the plasma membrane. Live-FRET, fast FRAP, fast confocal, TIRF microscopy in live cells expressing tagged langerin, RAB11A, Myosin Vb, FIP2 Traffic Medium 22420646
2013 RAB11A functions upstream of RAB8A to promote regulated exocytosis of discoidal/fusiform vesicles in bladder umbrella cells; myosin 5B cooperates with the RAB11A-RAB8A module, possibly by facilitating transit through the cortical actin cytoskeleton; Rabin8 (a RAB11A effector and RAB8 GEF) stimulates exocytosis independently of its GEF catalytic activity. Dominant-active/dominant-negative RAB11A and RAB8A expression, myosin 5B dominant-negative, catalytically inactive Rabin8 expression, stretch-induced exocytosis assay Molecular biology of the cell Medium 23389633
2013 Reggie-1 directly interacts with RAB11A and SNX4; reggie-1 knockdown reduces association of RAB11A with tubular structures and impairs transferrin receptor and E-cadherin recycling to the plasma membrane; these defects are rescued by overexpression of constitutively active RAB11A. siRNA knockdown, fluorescence microscopy, co-immunoprecipitation of reggie-1 and RAB11A, transferrin recycling assay, Ca2+-switch E-cadherin recycling assay Molecular biology of the cell Medium 23825023
2013 Rab11-FIPs define spatially and temporally distinct regions within the RAB11A-dependent recycling system; internalized transferrin enters different Rab11-FIP-containing compartments with distinct kinetics (FIP1B/FIP2 early; FIP1A/FIP1C/FIP3/FIP5 delayed), indicating temporal ordering of cargo passage through RAB11A recycling subdomains. Live-cell deconvolution microscopy, fluorescent transferrin kinetics in HeLa cells expressing chimeric fluorescent Rab11-FIPs Molecular biology of the cell Medium 23283983
2013 RAB11A mediates intracellular transport of measles virus RNP complexes in Rab11A-containing recycling endosomes in a microtubule-dependent manner; dominant-negative RAB11A severely impairs RNP apical accumulation and infectious virion shedding from polarized epithelial cells. Live-cell imaging with fluorescent protein-tagged L protein, dominant-negative RAB11A expression, nocodazole treatment, viral titer assay Journal of virology Medium 23408617
2014 TBC1D9B acts as a GAP for RAB11A in polarized MDCK cells; TBC1D9B interacts with RAB11A in a nucleotide-dependent manner via its TBC domain and specifically stimulates GTP hydrolysis on RAB11A (but not other Rabs tested at physiological Mg2+); TBC1D9B overexpression decreases active RAB11A, disrupts the RAB11A-Sec15A interaction, and slows IgA transcytosis, while TBC1D9B knockdown accelerates it. GTPase activity assay in vitro, co-immunoprecipitation, overexpression and shRNA knockdown of TBC1D9B, IgA transcytosis assay, active RAB11A pull-down Molecular biology of the cell High 25232007
2014 Rab11-FIP2 interacts with MYO5B via residues S229 and G233; mutations disrupting this interaction increase speed and track length of RAB11A-containing vesicle movement, consistent with impaired MYO5B-mediated tethering; Rab11-FIP2 knockdown phenocopies this. Random mutagenesis, yeast two-hybrid, HeLa cell expression assays, live-cell fluorescence microscopy of RAB11A vesicle dynamics Traffic Medium 24372966
2014 RAB11A is required for apical protein localization in mouse intestinal epithelial cells in vivo; intestine-specific RAB11A knockout mice show apical protein mislocalization to the basolateral membrane, shortened microvilli, and microvillus inclusion bodies; RAB8A mislocalizes in RAB11A knockout intestine, and RAB11A mislocalizes in RAB8A knockout intestine, indicating a functional relationship between RAB11A, RAB8A, and myosin Vb. Conditional knockout mouse, immunofluorescence, electron microscopy, epistasis analysis with RAB8A knockout Biology open High 25527643
2014 Loss of RAB11A in mouse embryonic fibroblasts impairs secretion of multiple soluble matrix metalloproteinases (MMPs); global RAB11A knockout embryos form normal blastocysts but die at peri-implantation stages. Global RAB11A knockout mouse, multiple trafficking assays, MMP secretion assays, complementation analysis The Journal of biological chemistry Medium 25271168
2014 RAB11A deficiency in enterocytes alters apical localization of syntaxin 3 and impairs microvillus assembly; conditional RAB11A knockout mice and stable RAB11A-knockdown CaCo2-BBE cells both show shortened or displaced microvilli, affirming RAB11A's role in apical membrane trafficking in intestinal cells. Conditional knockout mouse, stable shRNA knockdown, immunofluorescence, electron microscopy Journal of cell science Medium 25673875
2014 Myosin Vb and RAB11A control phosphorylation of ezrin at T567 in enterocytes; dominant-negative RAB11A or myosin Vb depletion prevents subapical enrichment of RAB11A and ezrin kinases and reduces ezrin phosphorylation and microvilli development; similar loss occurs in microvillus inclusion disease (MYO5B mutations). Dominant-negative RAB11A expression, myosin Vb knockdown, phospho-specific ezrin western blot, immunofluorescence Journal of cell science Medium 24413175
2014 MYO5B uncoupling from RAB11A induces microvillus inclusions in enterocytes; the MVID-associated MYO5B-P660L mutation loses interaction with RAB11A and causes microvillus inclusion formation; microvilli restoration requires RAB8A-MYO5B interaction, while microvillus inclusions are driven by loss of RAB11A-MYO5B interaction; early inclusions are SNX18-positive and derived from apical membrane internalization. Stable MYO5B knockdown in CaCo2-BBE cells, expression of WT and mutant MYO5B, surface biotinylation, immunofluorescence, co-immunoprecipitation The Journal of clinical investigation High 24892806
2015 RAB11A and Rab11-FIP2 mediate VE-cadherin recycling and vascular barrier integrity; VE-cadherin directly interacts with Rab11-FIP2 (at aa 453-484), forming a ternary complex with RAB11A; silencing RAB11A or Rab11-FIP2 prevents VE-cadherin recycling and junctional reannealing; selective pulmonary microvessel RAB11A knockdown increases vascular leakage in sepsis models. Yeast two-hybrid, co-immunoprecipitation, Ca2+-switch recycling assay, confocal imaging, siRNA knockdown, in vivo intratracheal siRNA, permeability assay Arteriosclerosis, thrombosis, and vascular biology High 26663395
2015 RAB11A inactivation in macrophages facilitates efferocytosis of apoptotic neutrophils via modulation of ADAM17-mediated CD36 surface expression; apoptotic cell feeding induces rapid loss of RAB11A activity; RAB11A knockdown increases surface CD36 by reducing ADAM17 surface levels; blockade of CD36 abolishes the augmented phagocytosis. siRNA knockdown, wild-type and dominant-negative RAB11A overexpression, flow cytometry for surface CD36/ADAM17, efferocytosis assay, in vivo instillation of RAB11A-depleted macrophages Journal of immunology Medium 28053235
2015 Huntingtin (HTT) forms a complex with PAR3, aPKC, and RAB11A, and ensures microtubule-dependent apical vesicular translocation of PAR3-aPKC through RAB11A; HTT depletion disrupts apical localization of PAR3-aPKC during mammary epithelial morphogenesis. Co-immunoprecipitation (HTT-PAR3-aPKC-RAB11A complex), conditional HTT depletion in vivo, immunofluorescence, mouse mammary epithelium model PLoS biology Medium 25942483
2015 RAB11A is essential for lamellar body biogenesis in human epidermis; RAB11A silencing in 3D reconstructed human epidermis reduces lamellar body density and secretion, misdirects lamellar body cargoes to lysosomes, decreases stratum corneum lipid content, and causes epidermal barrier defects. siRNA knockdown in 3D reconstructed human epidermis, electron microscopy, immunofluorescence, epidermal barrier function assay The Journal of investigative dermatology Medium 26872604
2016 RAB11A regulates ezrin phosphorylation and microvilli-associated membrane supply in neurons via LMTK1; LMTK1 knockout increases prevalence, velocity, and run length of anterograde RAB11A-positive endosome movement; a non-phosphorylatable LMTK1 mutant at Ser34 (Cdk5 phosphorylation site) dramatically promotes dendrite growth; Cdk5-LMTK1 axis negatively controls dendritic formation through regulation of RAB11A-positive endosomal trafficking. LMTK1 knockout mice, live-cell imaging of RAB11A-positive endosome dynamics, dominant-negative and constitutively active RAB11A expression, in vitro and in vivo cortical neuron cultures Molecular biology of the cell Medium 24672056
2017 ET-1 activates PKC, which phosphorylates RAB11A at serine 177, inhibiting RAB11A activity and reducing surface trafficking of BK channel β1 subunits in arterial smooth muscle cells; expression of phosphorylation-incapable RAB11A S177A blocks ET-1-induced effects; NO-induced RAB11A activation and vasodilation do not involve S177. PKC inhibitor, RAB11A S177A phosphorylation-incapable mutant expression, RAB11A activity assay, surface protein quantitation, patch-clamp electrophysiology, ex vivo vasoconstriction assay Circulation research High 28696251
2017 RAB11A promotes proliferation and invasion in non-small cell lung cancer via interaction with and upregulation of YAP protein; co-immunoprecipitation shows RAB11A-YAP interaction in lung cancer cells; YAP depletion abolishes RAB11A-induced cell cycle protein changes and proliferation. Co-immunoprecipitation, RAB11A overexpression/knockdown, YAP siRNA epistasis, cell proliferation and invasion assays Oncotarget Low 28468127
2018 RAB11A-positive recycling endosomes serve as a primary platform for autophagosome biogenesis; WIPI2 is recruited to RAB11A-positive membranes by binding RAB11A, and PI3P is generated on these membranes upon starvation; loss of RAB11A impairs recruitment and assembly of the autophagic machinery including WIPI2, ATG16L1, and LC3. RAB11A knockout/knockdown, confocal and live-cell imaging, WIPI2-RAB11A binding assay, PI3P detection on RAB11A membranes, LC3 lipidation assay, mitophagy and transferrin receptor autophagy assays Developmental cell High 29634932
2018 Rab11a and Rab8a act in a cascade (RAB11A upstream of RAB8A, independent of Rabin8 GEF activity) to regulate tunneling nanotube (TNT) formation; overexpression of both increases TNT-connected cells and intercellular vesicle propagation; VAMP3 acts downstream of RAB8A in this pathway. RAB11A and RAB8A overexpression/dominant-negative expression, Rabin8 catalytic mutant, live-cell imaging, TNT quantification, VAMP3 interference Journal of cell science Medium 30209134
2019 The LMTK1A-TBC1D9B-RAB11A cascade regulates dendritic spine formation; LMTK1 binds and controls the GAP activity of TBC1D9B on RAB11A; TBC1D9B inactivates RAB11A under LMTK1A control; depletion of LMTK1 or TBC1D9B increases spine formation and density in neurons in vitro and in vivo. Co-immunoprecipitation (LMTK1-TBC1D9B), in vitro GAP assay, siRNA/shRNA knockdown in primary neurons and in vivo mouse brain, spine density analysis by confocal microscopy The Journal of neuroscience High 31628178
2019 Myosin-5b motor function is activated by RAB11A binding to its globular tail domain (GTD), which abolishes the autoinhibitory head-GTD interaction; FIP2 bridges MYO5B and RAB11A on vesicles without directly activating the motor; RAB11A has higher affinity for FIP2 than for MYO5B, suggesting FIP2-mediated vesicle tethering with RAB11A-dependent motor activation. In vitro binding assays (RAB11A-MYO5B GTD interaction), ATPase/motor activity assay, affinity measurements Bioscience reports Medium 30545898
2020 The C9ORF72-SMCR8-WDR41 complex has GAP activity toward RAB11A and RAB8A; cryo-EM structure at 3.2 Å reveals that Arg147 of SMCR8 acts as the arginine finger critical for stimulating GTP hydrolysis by RAB11A; biochemical mutagenesis of R147 eliminates this GAP activity. Cryo-EM structure determination, in vitro GTPase activity assay with SMCR8 R147 mutant, biochemical analysis Proceedings of the National Academy of Sciences of the United States of America High 32303654
2020 RAB11A is directly activated (GTP-loaded) by the insulin signaling cascade in a PI3K- and Akt-dependent manner; GTP loading of RAB11A peaks ~4 min after insulin stimulation and is required for GLUT4 and FAT/CD36 trafficking in cardiomyocytes. Biotinylated GTP analog loading assay, PI3K/Akt inhibitor pharmacology, siRNA knockdown in H9c2-hIR cells Cellular signalling Medium 17158030
2020 RAB11A Rab11A-positive vesicles serve as hubs for congregation of influenza vRNP complexes, enabling vRNP:vRNP interactions required for specific genome assembly; RAB11A-deficient cells produce smaller vRNP bundles with reduced co-localization between distinct vRNA segments and generate non-infectious particles with high RNA copy-to-PFU ratios. Tetracysteine-tagged NP reporter virus, siRNA RAB11A depletion, fluorescence microscopy of vRNP dynamics, RNA copy number/PFU ratio assay PLoS pathogens Medium 33970958
2020 IAV infection decreases speed and increases arrest of RAB11A-positive recycling endosomes through a mechanism involving reduced dynein motor association with RAB11A vesicles; co-transport of RAB11A and vRNA was directly demonstrated in infected cells by two-color live imaging. High-spatiotemporal-resolution light-sheet microscopy, two-color live imaging, quantitative motion analysis, proteomic analysis of dynein association Nature communications Medium 31911620
2021 RAB11A mediates cell-cell spread of influenza A vRNPs via tunneling nanotubes (TNTs); in a system where conventional virion-mediated spread was blocked, vRNP transfer to neighboring cells was dependent on both actin and RAB11A; genome mixing and reassortment via TNT transfer was demonstrated. HA-deficient reporter virus system, actin disruption, RAB11A knockdown/dominant-negative, fluorescence microscopy of TNTs, infectious virus reassortment assay PLoS pathogens Medium 34473799
2021 RAB11A controls YAP localization to adherens and tight junctions in colonic epithelium; loss of RAB11A reduces YAP association with α-catenin, β-catenin, and Merlin, and causes nuclear YAP accumulation and increased β-catenin-YAP complex formation; RAB11A-deficient mice show reduced colonic epithelial integrity and impaired repair after chemical injury. Conditional RAB11A knockout mice, co-immunoprecipitation (YAP with junctional components), immunofluorescence, epithelial injury assay The Journal of biological chemistry Medium 34058200
2022 The C-terminal two-thirds of the influenza A virus PB2 polymerase subunit (PB2-C, comprising cap-binding, mid-link, 627, and NLS domains) directly interact with RAB11A; SAXS confirms a compact 1:1 stoichiometric complex in solution; the switch I region of RAB11A (used for Rab11-FIP binding) mediates PB2-C binding, indicating competition between viral polymerase and Rab11-FIPs for the same RAB11A site. Pulldown assays, mass spectrometry, small-angle X-ray scattering (SAXS), domain deletion mapping Journal of virology High 35019720
2023 RAB11A and RAB11B redundantly control mitotic spindle function in intestinal epithelial progenitor cells; compound RAB11A/RAB11B double-knockout causes mitotic spindle defects, cell cycle arrest, and apoptosis leading to lethality within 3 days; unbiased proteomics of RAB11A and RAB11B immunoprecipitates identified shared mitotic spindle microtubule regulators; disrupting RAB11 impairs KIF11 (kinesin motor) function and bipolar spindle formation. Double-knockout mouse model, enteroid culture, proteomic immunoprecipitation, KIF11 functional analysis, mitotic spindle imaging EMBO reports High 37424454
2023 Accessory ESCRT-III proteins CHMP1A, CHMP1B, CHMP5, and IST1 are selectively required for ILV formation in RAB11A-positive recycling endosomes but not in late endosomes; CHMP5 knockdown in HCT116 cells selectively inhibits RAB11A-exosome production without affecting late-endosome-derived exosomes. Comparative proteomics, Drosophila secondary cell knockdown, human HCT116 cell siRNA knockdown, electron microscopy of ILVs, exosome secretion assay Journal of extracellular vesicles Medium 36872252
2018 FLCN (folliculin, Birt-Hogg-Dubé protein) binds RAB11A via its C-terminal DENN-like domain; suppression of either RAB11A or FLCN redirects overexpressed PAT1 (amino acid transporter) to lysosomes and reduces its plasma membrane targeting; FLCN promotes loading of PAT1 onto RAB11A vesicles; FLCN does not have direct GEF activity on RAB11A in vitro. Co-immunoprecipitation of FLCN-RAB11A, in vitro GEF activity assay (negative result for FLCN), siRNA knockdown, PAT1 trafficking assay Journal of cell science Medium 30446510
2014 Rab11a-Rab8a double-knockout in neonatal enterocytes causes basolateral microvilli formation and more severe enteropathy than either single knockout; inducible Rab11a deletion alone from neonatal enterocytes induces basolateral microvilli within 3 days; distinct cargo sets depend individually on Rab8a or Rab11a, while some basolateral cargos are redundantly transported by both. Enterocyte-specific single and double conditional knockout mice, inducible Rab11a deletion, immunofluorescence, electron microscopy Journal of cell science High 28596241

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Molecular biology of the cell 345 9880326
2000 Regulation of vesicle trafficking in madin-darby canine kidney cells by Rab11a and Rab25. The Journal of biological chemistry 195 10869360
2018 The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A. Developmental cell 180 29634932
2010 The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity 175 20933442
2011 RAB11A is essential for transport of the influenza virus genome to the plasma membrane. Journal of virology 154 21525351
2005 Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells. Proceedings of the National Academy of Sciences of the United States of America 129 16214890
2009 Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein. The Journal of neuroscience : the official journal of the Society for Neuroscience 118 19193894
2002 Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience 111 12427833
2009 Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis. PLoS pathogens 95 19165333
2006 Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane. Molecular and cellular biology 95 16354700
2014 Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease. The Journal of clinical investigation 91 24892806
2007 Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. The Journal of biological chemistry 91 17462998
2019 Exosomes from MiR-21-5p-Increased Neurons Play a Role in Neuroprotection by Suppressing Rab11a-Mediated Neuronal Autophagy In Vitro After Traumatic Brain Injury. Medical science monitor : international medical journal of experimental and clinical research 83 30860987
1999 Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. The American journal of physiology 83 10484323
2003 Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells. Experimental cell research 82 14567990
2014 Rab11a is required for apical protein localisation in the intestine. Biology open 79 25527643
1998 Rab11a redistributes to apical secretory canaliculus during stimulation of gastric parietal cells. The American journal of physiology 75 9688847
2008 Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proceedings of the National Academy of Sciences of the United States of America 66 18843107
2023 Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation. Journal of extracellular vesicles 65 36872252
2013 Reggies/flotillins interact with Rab11a and SNX4 at the tubulovesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking. Molecular biology of the cell 65 23825023
2013 Rab11-family interacting proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling system. Molecular biology of the cell 64 23283983
2020 Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a. Proceedings of the National Academy of Sciences of the United States of America 61 32303654
2015 MiR-21 inhibits autophagy by targeting Rab11a in renal ischemia/reperfusion. Experimental cell research 61 26302266
2015 Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier Function. Arteriosclerosis, thrombosis, and vascular biology 60 26663395
2003 Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2. American journal of physiology. Cell physiology 59 12540381
2015 MicroRNA-320a inhibits proliferation and invasion of breast cancer cells by targeting RAB11A. American journal of cancer research 58 26609479
2014 Rab11-FIP2 interaction with MYO5B regulates movement of Rab11a-containing recycling vesicles. Traffic (Copenhagen, Denmark) 57 24372966
2009 Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. The Journal of biological chemistry 57 19542231
2015 Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes. Journal of cell science 56 25673875
2008 G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction. Molecular biology of the cell 56 18701709
2013 A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells. Molecular biology of the cell 53 23389633
2006 Rab11a differentially modulates epidermal growth factor-induced proliferation and motility in immortal breast cells. Breast cancer research and treatment 49 16791477
2017 Rab11a promotes proliferation and invasion through regulation of YAP in non-small cell lung cancer. Oncotarget 45 28468127
2014 Myosin Vb and Rab11a regulate phosphorylation of ezrin in enterocytes. Journal of cell science 44 24413175
2008 Tomato Rab11a characterization evidenced a difference between SYP121-dependent and SYP122-dependent exocytosis. Plant & cell physiology 44 18385165
2018 Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 43 30048990
2016 Rab11a sustains GSK3β/Wnt/β-catenin signaling to enhance cancer progression in pancreatic cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 43 27481517
2020 Long non-coding RNA NORAD contributes to the proliferation, invasion and EMT progression of prostate cancer via the miR-30a-5p/RAB11A/WNT/β-catenin pathway. Cancer cell international 42 33292272
2005 c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis. The American journal of pathology 42 15972968
2018 Rab11a-Rab8a cascade regulates the formation of tunneling nanotubes through vesicle recycling. Journal of cell science 41 30209134
2014 The lipid kinase PI4KIIIβ is highly expressed in breast tumors and activates Akt in cooperation with Rab11a. Molecular cancer research : MCR 40 24962317
2014 TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells. Molecular biology of the cell 40 25232007
2012 A Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane. Traffic (Copenhagen, Denmark) 40 22420646
2013 Intracellular transport of the measles virus ribonucleoprotein complex is mediated by Rab11A-positive recycling endosomes and drives virus release from the apical membrane of polarized epithelial cells. Journal of virology 39 23408617
2015 Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC. PLoS biology 38 25942483
2014 Global ablation of the mouse Rab11a gene impairs early embryogenesis and matrix metalloproteinase secretion. The Journal of biological chemistry 38 25271168
2017 Inactivation of Rab11a GTPase in Macrophages Facilitates Phagocytosis of Apoptotic Neutrophils. Journal of immunology (Baltimore, Md. : 1950) 37 28053235
2017 Intracellular Colocalization of Influenza Viral RNA and Rab11A Is Dependent upon Microtubule Filaments. Journal of virology 36 28724771
2007 Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism. Molecular endocrinology (Baltimore, Md.) 36 17426287
2020 Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association. Nature communications 35 31911620
2020 Rab11A regulates dense granule transport and secretion during Toxoplasma gondii invasion of host cells and parasite replication. PLoS pathogens 32 32463830
2015 Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins. The Journal of biological chemistry 32 26635365
2021 Rab11a mediates cell-cell spread and reassortment of influenza A virus genomes via tunneling nanotubes. PLoS pathogens 31 34473799
2016 Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors. PloS one 31 27529348
2013 A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases. The Journal of biological chemistry 31 24302731
2016 Reggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons. Experimental neurology 30 27993509
2014 LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes. Molecular biology of the cell 30 24672056
2007 Rab11A controls the biogenesis of Birbeck granules by regulating Langerin recycling and stability. Molecular biology of the cell 30 17538027
2019 The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience 29 31628178
2017 Endothelin-1 Stimulates Vasoconstriction Through Rab11A Serine 177 Phosphorylation. Circulation research 29 28696251
2008 Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase. Cellular signalling 29 18832025
2015 Reggie-1/Flotillin-2 regulates integrin trafficking and focal adhesion turnover via Rab11a. European journal of cell biology 28 26299802
2015 Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses. Virology 28 26484934
2016 Rab8a/Rab11a regulate intercellular communications between neural cells via tunneling nanotubes. Cell death & disease 27 28005071
2009 Regulation of cell death by recycling endosomes and golgi membrane dynamics via a pathway involving Src-family kinases, Cdc42 and Rab11a. Molecular biology of the cell 27 19641023
2021 Exocyst controls exosome biogenesis via Rab11a. Molecular therapy. Nucleic acids 26 35036064
2017 Tumor-suppressive microRNA-452 inhibits migration and invasion of breast cancer cells by directly targeting RAB11A. Oncology letters 26 28781694
2016 Rab11a Is Essential for Lamellar Body Biogenesis in the Human Epidermis. The Journal of investigative dermatology 26 26872604
2020 Rab11a regulates MMP2 expression by activating the PI3K/AKT pathway in human hepatocellular carcinoma cells. Pathology, research and practice 25 32825931
2017 Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy. Journal of cell science 25 28596241
2021 Host factor Rab11a is critical for efficient assembly of influenza A virus genomic segments. PLoS pathogens 24 33970958
2007 FIP2 and Rip11 specify Rab11a-mediated cellular distribution of GLUT4 and FAT/CD36 in H9c2-hIR cells. Biochemical and biophysical research communications 24 17854769
2021 RAB11A-mediated YAP localization to adherens and tight junctions is essential for colonic epithelial integrity. The Journal of biological chemistry 23 34058200
2017 Rab11a is required for porcine reproductive and respiratory syndrome virus induced autophagy to promote viral replication. Biochemical and biophysical research communications 22 28822762
2011 Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells. Experimental cell research 22 22036648
2007 The JNK/AP-1 pathway upregulates expression of the recycling endosome rab11a gene in B cells transformed by Theileria. Cellular microbiology 22 17388783
2019 Rab11a drives adhesion molecules to the surface of endometrial epithelial cells. Human reproduction (Oxford, England) 21 30597006
2013 GRAB is a binding partner for the Rab11a and Rab11b GTPases. Biochemical and biophysical research communications 21 24140058
2020 Rab11A Functions as a Negative Regulator of Osteoclastogenesis through Dictating Lysosome-Induced Proteolysis of c-fms and RANK Surface Receptors. Cells 19 33142674
2020 Rab11a Is Overexpressed in Gastric Cancer and Regulates FAK/AKT Signaling. Journal of oncology 19 33178272
2011 A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. Journal of cell science 18 21984810
2019 Regulation of Myosin-5b by Rab11a and the Rab11 family interacting protein 2. Bioscience reports 17 30545898
2018 Influenza A Virus NS1 Protein Suppresses JNK1-Dependent Autophagosome Formation Mediated by Rab11a Recycling Endosomes. Frontiers in microbiology 16 30619194
2017 MiR-150 Inhibits Cell Growth In Vitro and In Vivo by Restraining the RAB11A/WNT/β-Catenin Pathway in Thyroid Cancer. Medical science monitor : international medical journal of experimental and clinical research 16 29023429
2013 Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo. American journal of physiology. Cell physiology 16 24153428
2014 Nucleotide bound to rab11a controls localization in rod cells but not interaction with rhodopsin. The Journal of neuroscience : the official journal of the Society for Neuroscience 15 25378153
2024 Stress-induced Rab11a-exosomes induce amphiregulin-mediated cetuximab resistance in colorectal cancer. Journal of extracellular vesicles 14 38887984
2023 RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells. EMBO reports 14 37424454
2022 The C-Terminal Domains of the PB2 Subunit of the Influenza A Virus RNA Polymerase Directly Interact with Cellular GTPase Rab11a. Journal of virology 14 35019720
2006 A novel method to monitor insulin-stimulated GTP-loading of Rab11a in cardiomyocytes. Cellular signalling 14 17158030
2020 RAB11A mediates the proliferation and motility of esophageal cancer cells via WNT signaling pathway. Acta biochimica Polonica 13 33326197
2014 Distinct patterns of phosphatidylserine localization within the Rab11a-containing recycling system. Cellular logistics 13 25210648
2023 CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids. Stem cell reports 12 37541258
2022 RAB11A Expression Is Associated With Cancer Aggressiveness Through Regulation of FGFR-Signaling in Lung Squamous Cell Carcinoma. Annals of surgical oncology 12 35644860
2024 CircRAB11A act as miR-24-5p sponge promotes proliferation and resists apoptosis of chicken granulosa cell via EGFR/ERK1/2 and RAB11A/ PI3K/AKT pathways. Poultry science 11 38806000
2018 FLCN is a novel Rab11A-interacting protein that is involved in the Rab11A-mediated recycling transport. Journal of cell science 11 30446510
2010 Rab11a and its binding partners regulate the recycling of the ß1-adrenergic receptor. Cellular signalling 11 20727405
2022 Rab11a promotes the malignant progression of ovarian cancer by inducing autophagy. Genes & genomics 10 36125654
2022 RAB11A aggravates PDGF-BB-stimulated proliferation, migration, and inflammation of airway smooth muscle cells via affecting the NF-κB and PI3K/AKT pathways. Allergologia et immunopathologia 9 35789415
1995 The evolutionary relationships between homologs of ribosomal YL8 protein and YL8-like proteins. Current genetics 9 8536309

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