Affinage

RAB11B

Ras-related protein Rab-11B · UniProt Q15907

Length
218 aa
Mass
24.5 kDa
Annotated
2026-06-10
33 papers in source corpus 22 papers cited in narrative 22 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB11B is a small Rab GTPase that acts as an isoform-specific regulator of endosomal recycling, controlling the surface delivery and turnover of membrane proteins from recycling endosomes through a GTP/GDP nucleotide switch (PMID:10942597, PMID:14567990). It localizes to transferrin-positive recycling endosomes and to an apical pericentrosomal compartment that is distinct from and less microtubule-dependent than the compartment occupied by RAB11A, establishing a non-redundant identity from its closest paralog (PMID:10942597, PMID:14567990). Through this recycling activity RAB11B selectively governs apical surface expression of ion channels and transporters—CFTR, the epithelial Na+ channel ENaC, and acidosis-induced trafficking of V-ATPase—effects not substituted by RAB11A (PMID:19244346, PMID:22129970, PMID:20717956); the same recycling machinery drives integrin β1 return to the surface during metastatic adaptation and keratinocyte-stimulated melanin exocytosis (PMID:32541798, PMID:24141907). RAB11B also determines receptor fate by routing cargo toward degradation: it limits Cav1.2 channel density and directs c-Fms and RANK to lysosomes via an early-to-late-endosome–lysosome axis, thereby restraining osteoclastogenesis (PMID:21248079, PMID:33302495). Beyond recycling it has acquired roles in inflammasome control, restraining autophagic degradation of NLRP3 and, together with RAB11-FIP2, organizing NLRP3 inflammasome assembly and pyroptosis on early endosomes [PMID:38992121, PMID:bio_10.1101_2025.05.19.654879], and it redundantly cooperates with RAB11A to support mitotic spindle function, co-precipitating spindle regulators including KIF11 (PMID:37424454). Structurally, RAB11B engages partners through its switch and interswitch surfaces, as defined by its crystal complex with the PKG II leucine zipper, and its activity depends on HSP90 chaperoning and on regulators such as GRAB and SH3BP5 (PMID:25070890, PMID:34242681, PMID:24140058, PMID:29106825). De novo missense mutations (p.Val22Met, p.Ala68Thr) in the GTP/GDP-binding pocket lock RAB11B in an inactive, GDP-mimicking state and cause a neurodevelopmental syndrome with severe intellectual disability (PMID:29106825).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2000 Medium

    Established RAB11B as a functional regulator of endosomal recycling rather than merely a recycling-endosome resident, by showing nucleotide cycling and membrane attachment are both required for transferrin return to the surface.

    Evidence GFP-tagged active/inactive/prenylation-deficient mutants with transferrin recycling and colocalization assays

    PMID:10942597

    Open questions at the time
    • Effectors mediating the recycling step not identified
    • No distinction yet from RAB11A function
  2. 2003 Medium

    Defined RAB11B as a GTP-dependent switch between regulated and constitutive secretion in neuroendocrine cells and as a compartment distinct from RAB11A in polarized epithelia, beginning to separate paralog functions.

    Evidence PC12 hGH secretion assays with locked mutants; immunofluorescence and microtubule perturbation in MDCK and parietal cells

    PMID:14567990 PMID:14627637

    Open questions at the time
    • Molecular basis of RAB11A/RAB11B compartment segregation unknown
    • Cargo specificity not yet mapped
  3. 2009 High

    Demonstrated isoform-specific, non-redundant control of a defined cargo (CFTR), showing RAB11B but not RAB11A drives apical CFTR recycling and surface density.

    Evidence Dominant-negative/constitutively active mutants, RNAi, halide efflux, surface biotinylation and recycling-protection assays in T84 cells

    PMID:19244346

    Open questions at the time
    • Effector linking RAB11B to CFTR not identified
    • Generalization beyond CFTR untested at this point
  4. 2011 Medium

    Extended isoform-specific recycling to multiple epithelial transporters and showed RAB11B can also direct cargo to degradation, broadening its functional repertoire beyond anterograde recycling.

    Evidence Ussing chamber Na+ transport (ENaC), patch clamp and biotinylation (Cav1.2), Co-IP and siRNA for V-ATPase ε subunit with Rip11

    PMID:20717956 PMID:21248079 PMID:22129970

    Open questions at the time
    • How RAB11B selects recycling versus degradative fate is unresolved
    • Direct vs effector-mediated cargo recognition unclear
  5. 2012 Medium

    Placed RAB11B downstream of a signaling cascade by showing cAMP/PKA/CREB transcriptionally controls RAB11B expression to drive V-ATPase trafficking, linking second-messenger signaling to recycling capacity.

    Evidence Pharmacological PKA/Src/ERK perturbation, RT-PCR, immunoblot, siRNA in salivary duct cells

    PMID:22561749

    Open questions at the time
    • Direct CREB binding to RAB11B promoter not shown
    • Other transcriptional inputs unexplored
  6. 2013 Medium

    Identified RAB11B's direct binding partner GRAB and a physiological exocytic role in melanin transfer, beginning to define the protein interaction surface and tissue-specific outputs.

    Evidence Co-IP and deletion mapping of GRAB; siRNA depletion with electron microscopy and melanocyte–keratinocyte transfer assay

    PMID:24140058 PMID:24141907

    Open questions at the time
    • Functional consequence of GRAB binding for recycling not established
    • Whether GRAB acts as GEF for RAB11B untested
  7. 2014 High

    Resolved the structural basis of a RAB11B protein interaction, mapping the PKG II leucine zipper binding to switch I/II, interswitch and β1/N-terminal surfaces distinct from Rab11-FIP contacts.

    Evidence X-ray crystallography of the PKG II LZ–RAB11B complex with mutagenesis and in vitro binding

    PMID:25070890

    Open questions at the time
    • Cellular consequence of PKG II–RAB11B interaction not defined
    • Whether binding regulates RAB11B nucleotide state unknown
  8. 2015 Medium

    Showed RAB11B selectively recycles PAR1 and that its loss diverts cargo to lysosomal/autophagic degradation, establishing a recycling-versus-degradation decision node.

    Evidence siRNA trafficking screen, targeted RAB11B vs RAB11A knockdown, receptor recycling/degradation assays with ATG5 co-depletion

    PMID:26635365

    Open questions at the time
    • Mechanism routing cargo to autophagy upon RAB11B loss unclear
    • Effector specificity for PAR1 not identified
  9. 2017 Medium

    Linked RAB11B directly to human disease, showing GTP/GDP-pocket missense mutations lock the protein in an inactive, SH3BP5-binding state and cause a neurodevelopmental syndrome.

    Evidence Structural modeling, subcellular localization, and binary interaction assays with effectors/GEFs in patients with de novo mutations

    PMID:29106825

    Open questions at the time
    • Neuronal cargo/pathway disrupted in patients not identified
    • No animal model of the specific mutations
  10. 2020 Medium

    Connected RAB11B recycling to cancer cell adaptation and demonstrated pharmacological tractability, showing integrin β1 recycling enables mechanotransduction during brain metastasis and is blocked by statins.

    Evidence Drosophila genetic screen, surface proteomics, loss-of-function and integrin surface assays, statin treatment

    PMID:32541798

    Open questions at the time
    • Direct RAB11B–integrin recycling machinery not defined
    • Specificity of statin effect for RAB11B over other prenylated proteins unclear
  11. 2021 Medium

    Defined how RAB11B activity is supported and amplified, identifying it as an HSP90 client required for its lysosomal trafficking function and showing a SINEUP lncRNA enhances RAB11B translation.

    Evidence Reciprocal Co-IP, siRNA and 17-AAG in osteoclasts; RT-qPCR/Western with RAB11B-AS1 SINEUP assay in neuronal model

    PMID:34242681 PMID:34880900

    Open questions at the time
    • How HSP90 stabilizes RAB11B function mechanistically unclear
    • SINEUP regulation rests on a single low-confidence study
  12. 2023 High

    Revealed redundancy with RAB11A in an essential process, showing combined loss causes mitotic arrest and lethality and that RAB11B associates with spindle regulators including KIF11.

    Evidence Conditional double-knockout mouse, enteroid culture, proteomic IP, flow cytometry, spindle electron microscopy

    PMID:37424454

    Open questions at the time
    • Whether spindle role is direct or via recycling membrane is unresolved
    • KIF11 interaction not shown to be direct
  13. 2024 Medium

    Established a role in inflammation, showing RAB11B restrains autophagic degradation of NLRP3 to drive M1 macrophage polarization in alcohol-associated liver disease.

    Evidence Macrophage-specific AAV knockdown, overexpression in BMDM/RAW264.7, autophagic flux assays, in vivo ALD model

    PMID:38992121

    Open questions at the time
    • Direct molecular link between RAB11B and autophagic machinery unclear
    • Whether NLRP3 is a recycling cargo not addressed
  14. 2025 Medium

    Expanded RAB11B's roles to mitochondrial integrity, antiviral cargo maintenance, and endosomal inflammasome assembly, indicating its recycling activity shapes surface and organellar proteomes across contexts.

    Evidence Rab11b knockout mouse mitochondrial assays; siRNA and reverse genetics for H3N2 entry; FIP2–NLRP3 domain mapping with pyroptosis/PI4P endosome readouts (preprint)

    PMID:40248353 PMID:42227759 PMID:bio_10.1101_2025.05.19.654879

    Open questions at the time
    • Mechanism linking a recycling GTPase to mitochondrial integrity unexplained
    • Identity of the sialylated surface protein required for H3N2 entry unknown
    • Inflammasome findings rest on a single preprint

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RAB11B distinguishes recycling-to-surface from routing-to-degradation cargo, and which effectors confer its non-redundant specificity relative to RAB11A, remain unresolved.
  • No unifying effector code for cargo-fate decisions
  • Structural basis of RAB11A/RAB11B functional divergence undefined
  • Connection between membrane recycling and mitochondrial/spindle phenotypes mechanistically unexplained

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 4 GO:0098772 molecular function regulator activity 3
Localization
GO:0005768 endosome 4 GO:0031410 cytoplasmic vesicle 3 GO:0005815 microtubule organizing center 2
Pathway
R-HSA-9609507 Protein localization 4 R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-168256 Immune System 2 R-HSA-1640170 Cell Cycle 1
Partners
ATP6V1E1GRABHSP90AA1HSP90AB1KIF11PRKG2RAB11FIP2SH3BP5

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 RAB11B localizes to transferrin-positive recycling endosomes and is essential for recycling of internalized transferrin to the plasma membrane. Constitutively active (Q/L) and constitutively inactive (S/N) mutants both blocked transferrin recycling without affecting uptake; a prenylation-deficient mutant (ΔC) had no effect, indicating membrane association is required. GFP-tagged mutant overexpression, transferrin recycling assay, subcellular colocalization Experimental cell research Medium 10942597
2003 RAB11B in PC12 cells colocalizes with secretory vesicle markers. GDP-bound RAB11B stimulates constitutive secretion and depletes vesicular stores, while GTP-bound RAB11B directly impairs Ca2+-triggered exocytosis, demonstrating a GTP-dependent switch between regulated and constitutive secretory pathways in neuronal/neuroendocrine cells. Transfected hGH reporter in PC12 cells, constitutively active/inactive RAB11B mutants, secretion assays The Journal of neuroscience Medium 14627637
2003 Endogenous RAB11B localizes to an apical pericentrisomal compartment distinct from RAB11A in polarized epithelial cells (MDCK and gastric parietal cells); its distribution is less dependent on microtubules than RAB11A, and it does not substantially colocalize with transferrin or IgA cargo handled by RAB11A. Immunofluorescence of endogenous proteins, nocodazole/taxol perturbation, subcellular fractionation/coisolation Experimental cell research Medium 14567990
2009 RAB11B (but not RAB11A) selectively regulates apical recycling of CFTR in polarized intestinal epithelial (T84) cells. GDP-locked RAB11B-S25N inhibited ~80% of cAMP-activated halide efflux and reduced apical membrane CFTR by 50%; constitutively active RAB11B-Q70L increased stimulated efflux; RNAi knockdown of RAB11B (not RAB11A) reduced anion conductance by 50%. Dominant-negative/constitutively active mutant expression, RNAi knockdown, halide efflux assay, cell surface biotinylation, biotin protection recycling assay, immunoisolation of vesicles Molecular biology of the cell High 19244346
2011 RAB11B regulates apical recycling and surface expression of the epithelial sodium channel ENaC. Dominant-negative RAB11B (but not RAB11A) most effectively reduced basal and cAMP-stimulated ENaC-dependent Na+ transport; siRNA knockdown of RAB11B demonstrated its requirement for ENaC surface expression in mpkCCD cells. Dominant-negative mutant expression, siRNA knockdown, Ussing chamber Na+ transport assay, immunoisolation, confocal colocalization American journal of physiology. Renal physiology Medium 22129970
2011 RAB11B (not RAB11A) limits plasma membrane density of Cav1.2 L-type Ca2+ channels by promoting their degradation. Dominant-negative RAB11B-S25N or shRNA knockdown of RAB11B increased peak L-type Ba2+ current by ~64–66% and increased surface Cav1.2 density; cell surface biotinylation showed the effect is on degradation, not anterograde trafficking. Dominant-negative mutant, shRNA knockdown, whole-cell patch clamp, cell surface biotinylation, HA-tagged channel American journal of physiology. Cell physiology Medium 21248079
2011 RAB11B and its effector Rip11 regulate acidosis-induced trafficking of V-ATPase to the plasma membrane in salivary duct cells. RAB11B showed higher colocalization with V-ATPase than RAB11A; RAB11 (not RAB25) interacts with the ε subunit of V-ATPase; siRNA knockdown of RAB11B or Rip11 prevented acidosis-induced V-ATPase translocation. siRNA knockdown, confocal colocalization, co-immunoprecipitation (RAB11/V-ATPase ε subunit), immunofluorescence Journal of cellular physiology Medium 20717956
2012 The cAMP/PKA/CREB signaling pathway controls acidosis-induced V-ATPase trafficking in salivary ducts via transcriptional regulation of RAB11B expression; PKA phosphorylates CREB which activates RAB11B transcription, and CREB loss-of-function downregulates RAB11B and impairs V-ATPase translocation. Pharmacological inhibitors/activators of PKA/Src/ERK, RT-PCR, immunoblotting, siRNA loss-of-function The international journal of biochemistry & cell biology Medium 22561749
2013 RAB11B mediates keratinocyte-stimulated exocytosis of melanin (melanocores) from melanocytes, which is then endocytosed by keratinocytes. Depletion of RAB11B (but not RAB27A) markedly decreased both keratinocyte-stimulated melanin exocytosis and melanin transfer to keratinocytes. siRNA depletion of RAB11B vs RAB27A, electron microscopy of human skin, melanocyte-keratinocyte co-culture, functional transfer assay The Journal of investigative dermatology Medium 24141907
2013 GRAB (RAB3IL1/Rabin3-like 1) is a direct binding partner of RAB11B (and RAB11A but not RAB25). The RAB11B-binding region of GRAB maps to its carboxy-terminus, distinct from its GEF domain. Exogenous expression of RAB11B shifts GRAB distribution from cytoplasm to membranes. A GRAB deletion mutant (GRABΔ223-228) is deficient in RAB11B binding. Co-immunoprecipitation, deletion mutagenesis, subcellular localization by microscopy Biochemical and biophysical research communications Medium 24140058
2014 Crystal structure of the cGMP-dependent protein kinase II (PKG II) leucine zipper domain in complex with RAB11B was solved. The PKG II LZ domain dimerizes and interacts with RAB11B via a mostly nonpolar surface; contact surfaces in RAB11B include switch I and II, interswitch, and β1/N-terminal regions. This binding surface differs from the Rab11-family interacting protein (Rab11-FIP) complex surfaces. X-ray crystallography, mutagenic analysis, in vitro binding The Journal of biological chemistry High 25070890
2015 RAB11B (not RAB11A) is required for recycling of PAR1 (protease-activated receptor-1). siRNA depletion of RAB11B blocks PAR1 recycling and enhances lysosomal degradation of the receptor; in RAB11B-depleted cells, enhanced PAR1 degradation is redirected through an autophagic pathway (blocked by co-depletion of RAB11A or ATG5). siRNA library screen (140 trafficking proteins), targeted siRNA knockdown of RAB11B vs RAB11A, receptor recycling/degradation assays, fluorescence microscopy The Journal of biological chemistry Medium 26635365
2017 Two recurrent de novo missense mutations in RAB11B (p.Val22Met, p.Ala68Thr) alter the GTP/GDP binding pocket, produce localization patterns resembling inactive RAB11B, and induce RAB11B binding to the GEF SH3BP5, similar to inactive (GDP-bound) RAB11B, causing a neurodevelopmental syndrome with severe intellectual disability. 3D protein structure modeling, subcellular localization studies, binary interaction assay with effectors/GEFs (including SH3BP5) American journal of human genetics Medium 29106825
2020 RAB11B mediates recycling of integrin β1 to the cell surface, controlling the surface proteome during breast cancer brain metastatic adaptation. RAB11B-mediated integrin β1 surface expression enables engagement with brain ECM and activates mechanotransduction signaling for survival. Lipophilic statins prevent membrane association and activity of RAB11B. Time-course RNA-seq, Drosophila genetic screen, proteomic analysis of cell surface proteome, RAB11B loss-of-function, integrin β1 surface expression assays, statin treatment Nature communications Medium 32541798
2020 RAB11B inhibits osteoclastogenesis by directing c-Fms and RANK surface receptors to lysosomes for proteolytic degradation via early endosome–late endosome–lysosome axis; RAB11B overexpression enlarges early and late endosomes and abolishes surface RANK/c-Fms, attenuating NFATc1 signaling. Lysosomal inhibitor chloroquine rescued receptor degradation. RAW-D and bone marrow macrophage differentiation assay, RAB11B overexpression, chloroquine inhibition, immunofluorescence, endosome size measurement International journal of molecular sciences Medium 33302495
2021 RAB11B is an HSP90 client protein; RAB11B interacts with HSP90α and HSP90β in osteoclasts via the HSP90 ATPase domain (not requiring ATPase activity for turnover). Blocking HSP90–RAB11B interaction (by siHSP90 or 17-AAG) abrogates RAB11B-mediated lysosomal trafficking of c-Fms and RANK, thus alleviating RAB11B-dependent inhibition of osteoclastogenesis. Co-immunoprecipitation, siRNA knockdown, pharmacological inhibition (17-AAG), in vitro osteoclastogenesis Biochimica et biophysica acta. Molecular cell research Medium 34242681
2021 RAB11B-AS1 lncRNA (acting as a natural SINEUP) increases endogenous RAB11B protein levels without affecting RAB11B mRNA, demonstrating post-transcriptional upregulation of RAB11B by its antisense transcript through translational enhancement. CHD8 knockdown neuronal model, RT-qPCR (mRNA levels), Western blot (protein levels), SINEUP functional assay Frontiers in genetics Low 34880900
2023 RAB11A and RAB11B redundantly control mitotic spindle function in intestinal epithelial progenitor cells. Combined knockout of both (but not single knockouts) causes defective cell cycle entry, mitotic arrest, and apoptosis with complete lethality within 3 days. RAB11B immunoprecipitates contain mitotic spindle microtubule regulators including KIF11; RAB11 disruption impairs bipolar spindle formation. Conditional double-knockout mouse model, enteroid culture, proteomic immunoprecipitation, flow cytometry, electron microscopy of spindles EMBO reports High 37424454
2025 RAB11B is required for mitochondrial structural and functional integrity in gut epithelial cells (specifically Paneth cells). Rab11b knockout mouse intestines show altered mitochondrial protein targeting, impaired mitochondrial membrane potential, increased ROS production, and severe mitochondrial membrane defects by electron microscopy; RAB11B-specific interactome contains mitochondrial regulators. Rab11b conditional knockout mouse, transcriptomics, proteomic interactome, flow cytometry (membrane potential/ROS), electron microscopy Frontiers in cell and developmental biology Medium 40248353
2024 RAB11B promotes M1-like macrophage polarization in alcohol-associated liver disease by restraining autophagic degradation of NLRP3. RAB11B overexpression in macrophages inhibits autophagic flux, suppressing LC3B-mediated NLRP3 degradation; macrophage-specific RAB11B knockdown alleviates alcohol-induced liver inflammation. Macrophage-specific AAV knockdown, RAB11B overexpression in BMDM/RAW264.7, autophagic flux assay, immunofluorescence, in vivo ALD mouse model Acta pharmacologica Sinica Medium 38992121
2025 RAB11B (but not RAB11A) is required for H3N2 influenza A virus binding and entry; depletion of RAB11B reduced H3N2 virion binding to the cell surface by ~50%. This phenotype maps to the HA gene of H3N2 via reverse genetics and is not due to global changes in sialic acid levels but likely reflects loss of a specific sialylated surface protein(s) normally maintained at the surface by RAB11B recycling. siRNA depletion, single-cycle infection, RT-qPCR of bound virions, flow cytometry, reverse genetics/reassortant viruses, neuraminidase treatment Journal of virology Medium 42227759
2025 RAB11B (but not RAB11A) controls NLRP3 inflammasome activation in human macrophages downstream of RAB11-FIP2. RAB11-FIP2 interacts with NLRP3 via its N-terminal C2-domain (NLRP3 binds via KMKK motif); RAB11-FIP2 and RAB11B regulate caspase-1-mediated cleavage of pro-IL-1β and GSDMD and pyroptotic cell death on early endosomes; PI4P-positive endosome and ASC-speck formation are also controlled by this complex. Co-immunoprecipitation (FIP2-NLRP3 domain mapping), siRNA knockdown of RAB11B vs RAB11A, caspase-1 cleavage assay, GSDMD cleavage, pyroptosis assay, PI4P endosome imaging bioRxivpreprint Medium bio_10.1101_2025.05.19.654879

Source papers

Stage 0 corpus · 33 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis. Cancer research 139 31900259
2003 Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience 111 14627637
2022 METTL16 promotes hepatocellular carcinoma progression through downregulating RAB11B-AS1 in an m6A-dependent manner. Cellular & molecular biology letters 107 35596159
2013 Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis. The Journal of investigative dermatology 103 24141907
2009 Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells. Molecular biology of the cell 101 19244346
2000 Rab11b is essential for recycling of transferrin to the plasma membrane. Experimental cell research 83 10942597
2003 Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells. Experimental cell research 82 14567990
2010 Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B. PLoS pathogens 67 20686666
2007 Rab11B small GTPase regulates secretion of cysteine proteases in the enteric protozoan parasite Entamoeba histolytica. Cellular microbiology 62 17441984
1994 Molecular analysis of mouse Rab11b: a new type of mammalian YPT/Rab protein. Genomics 61 8001972
2011 Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC). American journal of physiology. Renal physiology 56 22129970
2020 Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth. Nature communications 51 32541798
2017 Recurrent De Novo Mutations Disturbing the GTP/GDP Binding Pocket of RAB11B Cause Intellectual Disability and a Distinctive Brain Phenotype. American journal of human genetics 39 29106825
2015 Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins. The Journal of biological chemistry 32 26635365
2011 Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts. Journal of cellular physiology 29 20717956
2011 Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels. American journal of physiology. Cell physiology 29 21248079
2013 GRAB is a binding partner for the Rab11a and Rab11b GTPases. Biochemical and biophysical research communications 21 24140058
2014 Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions. The Journal of biological chemistry 19 25070890
2018 Long non-coding RNA RAB11B-AS1 prevents osteosarcoma development and progression via its natural antisense transcript RAB11B. Oncotarget 18 29928484
2012 Acidosis-induced V-ATPase trafficking in salivary ducts is initiated by cAMP/PKA/CREB pathway via regulation of Rab11b expression. The international journal of biochemistry & cell biology 17 22561749
2021 A novel role of HSP90 in regulating osteoclastogenesis by abrogating Rab11b-driven transport. Biochimica et biophysica acta. Molecular cell research 15 34242681
2020 The Inhibitory Role of Rab11b in Osteoclastogenesis through Triggering Lysosome-Induced Degradation of c-Fms and RANK Surface Receptors. International journal of molecular sciences 15 33302495
2023 RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells. EMBO reports 14 37424454
2021 Natural SINEUP RNAs in Autism Spectrum Disorders: RAB11B-AS1 Dysregulation in a Neuronal CHD8 Suppression Model Leads to RAB11B Protein Increase. Frontiers in genetics 6 34880900
2012 The large conductance calcium-activated K(+) channel interacts with the small GTPase Rab11b. Biochemical and biophysical research communications 6 22935415
2024 Rab11b promotes M1-like macrophage polarization by restraining autophagic degradation of NLRP3 in alcohol-associated liver disease. Acta pharmacologica Sinica 5 38992121
2018 [Long non-coding RNA RAB11B-AS1 prevents osteosarcoma proliferation via its sense gene RAB11B]. Zhonghua yi xue za zhi 3 30139005
2025 Rab11b is necessary for mitochondrial integrity and function in gut epithelial cells. Frontiers in cell and developmental biology 2 40248353
2025 Rab11B is required for binding and entry of recent H3N2, but not H1N1, influenza A isolates. bioRxiv : the preprint server for biology 1 41332559
2020 Rab11B participates in erythrocyte storage lesion of under-collected whole blood. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 1 33341364
2026 Long Non-Coding RNA RAB11B-AS1 Suppresses Cervical Cancer Progression by Upregulating RPL26 Expression. Frontiers in bioscience (Landmark edition) 0 41609088
2026 Rab11B is required for binding and entry of recent H3N2, but not H1N1, influenza A isolates. Journal of virology 0 42227759
2025 Distribution analysis of RAB11A and RAB11B, small GTP-binding proteins, in mice. Molecular biology reports 0 39883192

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