Affinage

HSP90AB1

Heat shock protein HSP 90-beta · UniProt P08238

Length
724 aa
Mass
83.3 kDa
Annotated
2026-06-10
60 papers in source corpus 30 papers cited in narrative 30 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

HSP90AB1 (HSP90beta) is an ATP-dependent molecular chaperone that selectively binds misfolded client proteins and, by stabilizing diverse signaling clients against degradation, acts as a context-dependent amplifier of oncogenic and inflammatory signaling (PMID:32696774, PMID:40664262). Its chaperone cycle depends on ATPase activity and on assembly with the co-chaperone CDC37, and pharmacological inhibition of the ATPase or disruption of the HSP90AB1–CDC37 complex destabilizes client kinases such as AKT1 and ERBB2 (PMID:18218611, PMID:41114929). A recurring theme is stabilization of receptors and signaling nodes that drive Wnt/β-catenin and PI3K/AKT output: HSP90AB1 directly binds the Wnt co-receptor LRP5 to block its ubiquitin-mediated degradation and activate AKT and β-catenin signaling (PMID:30305727), binds B7-1 in podocytes through N-terminal residue K69 to relay signals to LRP5/β-catenin (PMID:35710882), and binds LGR5 to promote GSK-3β phosphorylation, β-catenin nuclear translocation, and androgen-receptor-driven enzalutamide resistance (PMID:40280884). It similarly supports TGFβ/SMAD signaling via interaction with EEF1A2 and elevation of TGFβ receptors (PMID:33473168), and stabilizes additional clients including COX-2, ACT1, TXN, PIK3CG, EGFR and KDM5C to sustain inflammatory and proliferative programs (PMID:39914036, PMID:41707809, PMID:41675575, PMID:40664262). HSP90AB1 also governs client localization and turnover directly: it retains Bcr-Abl in the cytoplasm through an N-terminal-domain interaction to maintain kinase activity (PMID:34217296), and it mediates K63-linked ubiquitination and degradation of ITGBL1 to restrain ER-stress-induced autophagy (PMID:41697125). Beyond the cytoplasm, extracellular and cell-surface HSP90AB1 binds and inactivates latent TGFβ and serves as an entry/replication factor for multiple viruses, with the NM/NTD domain engaging the RGNNV capsid protein (competitively displacing AKT) and the coronavirus N protein, and its ATPase activity being required for PDCoV and TGEV infection (PMID:34976221, PMID:34904422, PMID:38092149, PMID:37958953). HSP90AB1 activity is tuned by post-translational modification—SUMOylation at Lys72 (erased by SENP1) controls STAT3-driven fibrosis, chemerin-induced SUMO2/3 conjugation drives ERK1/2 activation in monocytes, and ACOX1-derived crotonyl-CoA crotonylates Lys265 to compact the chaperone and strengthen TXN binding under hypoxia (PMID:38992961, PMID:40744335, PMID:41675575)—and by transcriptional and post-transcriptional control through USP22-dependent H3K9 acetylation, SP1, IGF2BP3-mediated m6A mRNA stabilization, and HNRNPH1 (PMID:31801945, PMID:39914036, PMID:40105114, PMID:40468317).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2008 High

    Established that HSP90AB1 chaperone activity is druggable at a site distinct from classical inhibitors and that its function is required to maintain key oncogenic clients.

    Evidence Affinity purification with gamendazole, MALDI-TOF, and in vitro luciferase-refolding assay using purified HSP82, with client degradation readouts

    PMID:18218611

    Open questions at the time
    • Used yeast HSP82 homolog rather than human protein for refolding assay
    • Distinct binding site inferred from competition, not structurally resolved
  2. 2018 High

    Showed HSP90AB1 directly stabilizes a Wnt co-receptor, linking the chaperone to β-catenin/AKT-driven EMT.

    Evidence Co-IP, GST pull-down, in vitro ubiquitination assay, and xenograft models in gastric cancer

    PMID:30305727

    Open questions at the time
    • Binding interface on LRP5 not mapped
    • Whether stabilization is ATPase-dependent not tested
  3. 2019 Medium

    Identified epigenetic transcriptional control of HSP90AB1 via USP22-maintained H3K9 acetylation, explaining how its abundance is set.

    Evidence siRNA knockdown, mRNA-seq, H3K9ac ChIP, and tissue-specific Usp22 knockout mice

    PMID:31801945

    Open questions at the time
    • Direct vs indirect USP22 action at the locus not fully separated
    • Does not address protein-level regulation
  4. 2021 Medium

    Defined N-terminal-domain-dependent cytoplasmic retention of Bcr-Abl as a mechanism by which HSP90AB1 sustains oncogenic kinase signaling.

    Evidence IP-MS, domain mapping, immunofluorescence localization, and apoptosis assays in CML cells

    PMID:34217296

    Open questions at the time
    • Single-lab domain mapping without structural confirmation
    • Whether ATPase cycling is needed for retention untested
  5. 2021 Medium

    Connected HSP90AB1 to TGFβ/SMAD signaling through an EEF1A2 interaction that upregulates TGFβ receptors.

    Evidence LC-MS/MS interactome, reciprocal Co-IP, and functional assays in lung adenocarcinoma

    PMID:33473168

    Open questions at the time
    • Mechanism linking interaction to receptor upregulation unclear
    • Direct vs scaffolded interaction not resolved
  6. 2022 High

    Demonstrated a residue-resolved scaffold function (K69) coupling B7-1 to LRP5/β-catenin in podocyte injury.

    Evidence LC-MS/MS, molecular docking, site-directed mutagenesis, Co-IP, and nephropathy mouse models

    PMID:35710882

    Open questions at the time
    • Docking-based interface not crystallographically confirmed
    • Chaperone-cycle dependence not addressed
  7. 2022 Medium

    Revealed an extracellular, anti-tumor role: secreted HSP90AB1 binds and inactivates latent TGFβ and suppresses osteoclast maturation.

    Evidence Immunoprecipitation from conditioned-medium proteomes, whole-genome proteomics, and in vivo osteolysis model

    PMID:34976221

    Open questions at the time
    • Direct TGFβ-binding interface not mapped
    • Secretion mechanism not defined
  8. 2022 Medium

    Showed surface HSP90ab1 is hijacked by a viral capsid that competitively displaces AKT, coupling the chaperone to AKT-mTOR and autophagy during infection.

    Evidence Co-IP, domain mapping, and autophagy flux assays in fish cell lines (LjHSP90ab1)

    PMID:34904422

    Open questions at the time
    • Fish ortholog; mammalian conservation of mechanism untested
    • Competition shown biochemically but not structurally
  9. 2023 High

    Established HSP90AB1 ATPase activity as a host requirement for coronavirus infection through stabilization of the viral N protein.

    Evidence Genome-wide CRISPR screen, Co-IP, domain deletion mapping, and ATPase-selective inhibitor comparison (PDCoV)

    PMID:38092149

    Open questions at the time
    • Whether N stabilization fully accounts for the replication requirement unknown
  10. 2023 Medium

    Confirmed isoform-specific (HSP90AB1 over HSP90AA1) ATPase-dependent requirement for another coronavirus, generalizing the host-factor role.

    Evidence Isoform-specific knockdown/KO, time-of-addition inhibitor assay, and viral titering (TGEV)

    PMID:37958953

    Open questions at the time
    • Direct viral client interaction not biochemically defined here
  11. 2024 High

    Identified SUMOylation at Lys72, reversed by SENP1, as a switch controlling STAT3-driven cardiac fibrosis.

    Evidence Cardiomyocyte-specific SENP1 KO/OE mice, K72 mutagenesis, and cardiac phenotyping

    PMID:38992961

    Open questions at the time
    • SUMO ligase writing the K72 mark not identified
    • Mechanism linking SUMO to STAT3 activation unclear
  12. 2025 High

    Mapped distinct small-molecule binding residues (Asp88, Ser108) whose engagement disrupts client stabilization, refining the druggable surface.

    Evidence CETSA/TPP/MST/SPR biophysics, site-directed mutagenesis, and client destabilization (ACT1; PIK3CG/EGFR/KDM5C)

    PMID:40664262 PMID:41707809

    Open questions at the time
    • Relationship of these residues to the ATPase pocket not defined
    • Client specificity determinants unresolved
  13. 2025 Medium

    Expanded post-transcriptional and transcriptional regulation of HSP90AB1 (SP1, IGF2BP3/m6A, HNRNPH1) and added a chemerin-induced SUMO2/3-ERK1/2 axis.

    Evidence Promoter/ChIP analyses, m6A-seq/RIP-seq with site mutagenesis, RIP, and IP-MS with SUMO inhibitor

    PMID:39914036 PMID:40105114 PMID:40468317 PMID:40744335

    Open questions at the time
    • Interplay between competing positive and negative regulators not integrated
    • Some functional links (HNRNPH1→autophagy) indirect
  14. 2026 Medium

    Showed metabolic crotonylation at Lys265 conformationally tunes the chaperone to strengthen TXN binding and confer redox-driven drug resistance, and that HSP90AB1 can also direct K63-ubiquitin-mediated client degradation.

    Evidence Molecular dynamics, K265R mutagenesis, Co-IP, ATPase/ITGBL1 ubiquitination assays, and in vivo tumor models

    PMID:41675575 PMID:41697125

    Open questions at the time
    • Conformational effect from MD only, not an experimental structure
    • How HSP90AB1 selects clients for stabilization vs degradation unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how HSP90AB1's full client repertoire and the combinatorial PTM/regulatory code dictate context-specific outcomes (stabilization vs degradation, intracellular vs secreted/surface roles).
  • No integrated structural model of PTM effects on the chaperone cycle
  • Determinants of client fate (stabilize vs K63-degrade) undefined
  • Mechanism of HSP90AB1 secretion and surface presentation uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 5 GO:0140657 ATP-dependent activity 3 GO:0001618 virus receptor activity 2 GO:0044183 protein folding chaperone 2 GO:0060090 molecular adaptor activity 2
Localization
GO:0005576 extracellular region 2 GO:0005886 plasma membrane 2 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-9612973 Autophagy 2
Partners
B7-1BCR-ABLCDC37EEF1A2ITGBL1LGR5LRP5PARP1
Complex memberships
HSP90AB1-CDC37 co-chaperone complex

Evidence

Reading pass · 30 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2018 HSP90AB1 directly interacts with LRP5 (a Wnt co-receptor) via co-immunoprecipitation and GST pull-down, inhibiting ubiquitin-mediated proteasomal degradation of LRP5 and thereby stabilizing it; this stabilization activates AKT and Wnt/β-catenin signaling to promote epithelial-mesenchymal transition in gastric cancer cells. Co-immunoprecipitation, GST pull-down, in vitro ubiquitination assay, immunofluorescence, gain/loss-of-function in cell lines and xenograft mouse models Oncogene High 30305727
2008 HSP90AB1 (HSP90beta) is a direct binding target of gamendazole; the drug binds purified yeast HSP82 (mammalian HSP90AB1 homologue), inhibits its luciferase-refolding (chaperone) activity, causes degradation of HSP90-dependent client proteins AKT1 and ERBB2, and does not compete with geldanamycin or novobiocin for binding, suggesting a distinct binding site. Biotinylated affinity purification, MALDI-TOF mass spectrometry, Western blot, in vitro luciferase refolding assay with purified HSP82 Biology of reproduction High 18218611
2021 EEF1A2 physically interacts with HSP90AB1 (confirmed by LC-MS/MS and Co-IP), and this interaction increases TGFβ receptor I and II expression, followed by enhanced SMAD3 phosphorylation and nuclear localization, promoting EMT in lung adenocarcinoma cells. LC-MS/MS interactome, co-immunoprecipitation, immunofluorescence, in vitro and in vivo functional assays British journal of cancer Medium 33473168
2022 HSP90AB1 physically interacts with B7-1 in podocytes via residue K69 in the N-terminal domain of HSP90AB1 (identified by LC-MS/MS and confirmed by molecular docking and mutant analysis), acting as a scaffold to transmit signals from B7-1 to LRP5/β-catenin, thereby mediating podocyte injury and glomerulosclerosis. LC-MS/MS, molecular docking, site-directed mutagenesis, co-immunoprecipitation, transgenic/adriamycin nephropathy mouse models Cell death and differentiation High 35710882
2021 HSP90AB1 interacts with the coiled-coil (CC) domain of Bcr-Abl via its N-terminal domain (NTD), retaining Bcr-Abl in the cytoplasm and maintaining Bcr-Abl tyrosine kinase activation; disruption of this interaction (by 17AAG targeting NTD) permits nuclear translocation of Bcr-Abl, which activates p73 and induces apoptosis of CML cells. Immunoprecipitation-mass spectrometry, immunoprecipitation with domain mapping, immunofluorescence, Western blot, CCK-8, flow cytometry Cell communication and signaling Medium 34217296
2022 HSP90AB1 immunoprecipitates latent TGFβ (from osteoblast-secreted proteomes) and inactivates it; extracellular HSP90AB1 also inhibits tumor cell growth and osteoclast maturation in a mouse model of osteolysis. Immunoprecipitation (from conditioned medium proteomes), whole-genome proteomics, gain/loss-of-function, in vivo mouse osteolysis model Theranostics Medium 34976221
2019 USP22 deubiquitylase positively regulates HSP90AB1 expression at the transcriptional level via maintenance of H3K9 acetylation on the HSP90AB1 gene; siRNA knockdown of USP22 reduces H3K9ac at the HSP90AB1 locus and decreases HSP90AB1 mRNA and protein in colorectal and breast cancer cells and in tissue-specific Usp22 knockout mice. siRNA knockdown, mRNA-seq, Western blot, ChIP (H3K9ac), mouse tissue-specific Usp22 knockout Cell death & disease Medium 31801945
2022 RGNNV capsid protein (CP) binds the NM domain of fish HSP90ab1 (LjHSP90ab1) on the cell surface, competitively blocking AKT interaction with HSP90ab1, thereby inhibiting the AKT-mTOR pathway and inducing incomplete autophagy (impaired autophagosome-lysosome fusion) during early viral infection. Co-immunoprecipitation, domain mapping, Western blot, autophagy flux assays in fish cell lines Zoological research Medium 34904422
2023 HSP90AB1 interacts with the N, NS7, and NSP10 proteins of PDCoV (porcine deltacoronavirus); the C-tail domain of the N protein mediates interaction with HSP90AB1, and HSP90AB1 protects N protein from proteasomal degradation. ATPase activity of HSP90AB1 is required for PDCoV infection (ATPase-inhibiting HSP90 inhibitors suppressed infection, but KW-2478, which does not affect ATPase, had no effect). Genome-wide CRISPR screen, Co-IP, domain deletion mapping, HSP90 inhibitor treatment, proteasome inhibitor rescue assay, viral titer measurement Journal of biological chemistry High 38092149
2024 SENP1-mediated deSUMOylation of HSP90ab1 at Lys72 suppresses STAT3 activation and fibronectin secretion in cardiomyocytes; loss of SENP1 increases HSP90ab1 SUMOylation, activates STAT3, and drives paracrine fibroblast activation and cardiac fibrosis after myocardial infarction. Mutation of HSP90ab1 Lys72 (SUMOylation site) ameliorates adverse ventricular remodeling. Cardiomyocyte-specific SENP1 KO and overexpression mice, site-directed mutagenesis (K72 mutation), Western blot, cardiac function measurement, histology Advanced science High 38992961
2023 DSCC1 interacts with HSP90AB1 (confirmed by co-immunoprecipitation) and promotes ER stress-mediated progression of lung adenocarcinoma; knockdown of either protein reduces LUAD cell proliferation, stemness, EMT, and metastatic potential. Co-immunoprecipitation, siRNA knockdown, in vitro cell assays, in vivo tumor models Cancer cell international Low 37742009
2016 HSP90AB1 knockdown reduces phospho-AKT (Ser473) levels in head and neck squamous cell carcinoma cells, placing HSP90AB1 upstream of AKT activation in HNSCC. Lentiviral shRNA knockdown, Western blot for phospho-AKT, CCK-8/EdU/colony/transwell/xenograft assays Technology in cancer research & treatment Low 35929142
2022 HSP90AB1 knockdown in T cells reduces p-AKT, SMARCC1, p-c-Fos, and p-c-Jun expression and increases ROS and apoptosis; overexpression of HSP90AB1 inhibits capecitabine-induced T cell apoptosis by sustaining the AKT/SMARCC1/AP-1 axis and reducing ROS, establishing HSP90AB1 as a pro-survival regulator in T cells via this signaling cascade. siRNA knockdown, overexpression, quantitative proteomics/phosphoproteomics, Western blot, ROS measurement, flow cytometry apoptosis assay Oxidative medicine and cellular longevity Medium 35368874
2023 PARP1 interacts with HSP90AB1 (confirmed by Co-IP), and HSP90AB1 counteracts PARP1's repression of BLM promoter activity; HSP90AB1 thus acts as a co-regulator that de-represses BLM transcription in prostate cancer cells. Co-immunoprecipitation, DNA pull-down with promoter probe, dual luciferase reporter assay, ChIP-qPCR, MS Journal of translational medicine Medium 37415147
2023 CDK1-SRC interaction transcriptionally activates HSP90AB1 expression in hepatocellular carcinoma; manipulation of SRC or HSP90AB1 reverses the effects of CDK1 and SRC on HCC cell proliferation and migration, placing HSP90AB1 downstream of the CDK1-SRC kinase network. In vitro and in vivo functional assays, transcriptomic/proteomic analysis, siRNA/overexpression experiments Journal of proteome research Low 37949475
2018 Calenduloside E (CE) directly binds purified recombinant HSP90AB1 protein, as confirmed by competitive binding assay with CE-P probe and surface plasmon resonance (SPR) kinetic analysis showing dose-dependent binding. Clickable activity-based probe affinity purification, proteomic identification, competitive binding assay with purified recombinant HSP90AB1, SPR Frontiers in pharmacology Medium 29875664
2023 HSP90AB1 is required for transmissible gastroenteritis virus (TGEV) infection; knockdown of HSP90AB1 (but not HSP90AA1) and treatment with VER-82576 (an ATPase-inhibiting HSP90 inhibitor) reduce TGEV mRNA, N protein, and virus titers in a dose-dependent manner, with the inhibitory effect occurring mainly at early viral replication. siRNA knockdown, KO cells, HSP90 inhibitor time-of-addition assay, viral titer measurement, RT-qPCR, Western blot International journal of molecular sciences Medium 37958953
2025 LGR5 directly binds HSP90AB1 (confirmed by GST pull-down and Co-IP), and this interaction promotes phosphorylation of GSK-3β, leading to β-catenin stabilization and nuclear translocation that activates AR transcription, conferring enzalutamide resistance in prostate cancer; reducing HSP90AB1-LGR5 binding restores enzalutamide sensitivity. GST pull-down, co-immunoprecipitation, immunofluorescence, Western blot, in vitro and in vivo functional assays Chinese medical journal Medium 40280884
2025 Polydatin specifically binds HSP90AB1 at the Asp88 residue and disrupts HSP90AB1-mediated stabilization of the client protein ACT1, thereby suppressing the IL-17/MAPK/NF-κB inflammatory pathway in acute lung injury models. CETSA, thermal proteome profiling, mass spectrometry, site-directed mutagenesis, molecular docking, MST, cell lines overexpressing HSP90AB1, Western blot, in vivo rat ALI model Journal of ethnopharmacology High 41707809
2025 Bruceine A (BRA) binds HSP90AB1 at the Ser-108 residue and inhibits its chaperone function; downstream HSP90AB1 client/partner proteins PIK3CG, EGFR, and KDM5C are destabilized, suppressing HCC cell proliferation and inducing apoptosis. Chemical proteomics (MST, SPR, CETSA), site-directed mutagenesis, HSP90AB1 knockdown, TMT-based proteomics for downstream clients, patient-derived organoids and xenograft models Journal of advanced research High 40664262
2026 ACOX1-dependent increase in crotonyl-CoA under hypoxia drives site-specific crotonylation of HSP90AB1 at Lys265; molecular dynamics simulations show K265 crotonylation induces conformational compaction of HSP90AB1, strengthening its interaction with client protein TXN (thioredoxin) and enhancing TXN stability to buffer ROS and confer cisplatin resistance in oral squamous cell carcinoma. Molecular dynamics simulation, site-directed mutagenesis (K265R), co-immunoprecipitation, Western blot, in vitro and in vivo tumor models, pharmacological inhibition of ACOX1 Research (Washington, D.C.) Medium 41675575
2025 Chemerin stimulates SUMO2/3 conjugation to HSP90AB1 in monocytes via β2 integrin signaling; this SUMOylation of HSP90AB1 is essential for downstream ERK1/2 phosphorylation and monocyte activation and adhesion, as shown by immunoprecipitation/LC-MS/MS identification and reversal with SUMOylation inhibitor ML-792. Immunoprecipitation, LC-MS/MS, SUMOylation inhibitor (ML-792), Western blot, monocyte adhesion assay Cellular signalling Medium 40744335
2026 HSP90AB1 interacts with ITGBL1 and mediates its K63-linked ubiquitination and degradation; loss of this HSP90AB1-dependent degradation of ITGBL1 activates ER stress-induced autophagy, suppressing osteosarcoma progression. Co-IP, domain mapping, ubiquitination assay (K63-linkage), in vitro and in vivo functional assays, virtual screening and Co-IP for inhibitor (ivermectin) Advanced science Medium 41697125
2025 IGF2BP3 (m6A reader) binds m6A-tagged HSP90AB1 mRNA and stabilizes it in an m6A-dependent manner, increasing HSP90AB1 protein levels which activate the PI3K/AKT signaling pathway to promote bladder cancer progression. RNA-seq, m6A-seq, RIP-seq, RIP-qPCR, site-directed mutagenesis of m6A sites, Western blot, in vitro and in vivo assays FEBS journal Medium 40105114
2025 HNRNPH1 binds HSP90AB1 mRNA and inhibits its protein expression; this suppresses HSP90AB1-mediated inhibition of MAP1LC3B-dependent autophagy, thereby restraining lung adenocarcinoma malignant phenotype. RIP (RNA binding protein immunoprecipitation), siRNA/overexpression, Western blot, in vivo tumor models, autophagy flux assays Respiratory research Low 40468317
2024 GLCCI1 directly interacts with HSP90AB1 (confirmed by Co-IP), and HSP90AB1 in turn interacts with GRP78; GLCCI1 acts as an upstream regulator of HSP90AB1, which then regulates GRP78-initiated ER stress-induced apoptosis in retinal ganglion cells during diabetic retinopathy. Co-immunoprecipitation, GLCCI1 overexpression/knockdown, Western blot for GRP78/CHOP/caspase-3, in vivo DR mouse model Scientific reports Medium 39496608
2022 HSP90ab1 and Myh9 (non-muscle myosin) interact via immunoprecipitation; extracellular HSP90ab1 and Myh9 secreted by PI3K-activated MSCs exert anti-tumor effects and inhibit osteoclast maturation. Immunoprecipitation from conditioned medium, mass spectrometry, in vitro and in vivo tumor suppression assays Molecular therapy oncolytics Low 36090473
2025 SP1 transcription factor drives HSP90ab1 transcription by binding its promoter; pharmacological inhibition of SP1 reduces Hsp90ab1 expression; Hsp90ab1 in turn stabilizes the client protein COX-2 via p38/JNK signaling in uterine tissue, mediating primary dysmenorrhea. Promoter binding analysis (SP1 ChIP implied), geldanamycin inhibition of Hsp90ab1, lentiviral Hsp90ab1 overexpression reversal, Western blot, in vivo mouse PD model Bioorganic chemistry Medium 39914036
2020 HSP90ab1 specifically adsorbs to denatured (misfolded) proteins in nanoparticle protein coronas; the level of HSP90ab1 adsorption correlates with circular dichroism and ANS fluorescence measures of protein denaturation, validating that HSP90ab1 functions as a chaperone that selectively binds misfolded/denatured client proteins in vitro. Western blot of NP-corona complex, circular dichroism, ANS fluorescence spectroscopy, comparison across NP types and surface modifications Nanoscale Low 32696774
2025 NB (Dictamni Cortex nanoparticles) suppresses HSP90AB1 transcription by inhibiting its activator CTCF, and disrupts the HSP90AB1-CDC37 co-chaperone complex, thereby inactivating client proteins STAT3 and AKT in keratinocytes. Nascent proteomics, Western blot, co-chaperone complex disruption assay, in vitro keratinocyte and in vivo mouse psoriasis model Advanced science Low 41114929

Source papers

Stage 0 corpus · 60 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 HSP90AB1: Helping the good and the bad. Gene 140 26358502
2018 Hsp90ab1 stabilizes LRP5 to promote epithelial-mesenchymal transition via activating of AKT and Wnt/β-catenin signaling pathways in gastric cancer progression. Oncogene 99 30305727
2008 Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells. Biology of reproduction 71 18218611
2022 Suppression of breast cancer-associated bone loss with osteoblast proteomes via Hsp90ab1/moesin-mediated inhibition of TGFβ/FN1/CD44 signaling. Theranostics 57 34976221
2011 Polymorphisms in the bovine HSP90AB1 gene are associated with heat tolerance in Thai indigenous cattle. Tropical animal health and production 52 22008953
2021 EEF1A2 interacts with HSP90AB1 to promote lung adenocarcinoma metastasis via enhancing TGF-β/SMAD signalling. British journal of cancer 49 33473168
2021 Neurodegeneration and Astrogliosis in the Human CA1 Hippocampal Subfield Are Related to hsp90ab1 and bag3 in Alzheimer's Disease. International journal of molecular sciences 44 35008592
2019 USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer. Cell death & disease 39 31801945
2022 B7-1 mediates podocyte injury and glomerulosclerosis through communication with Hsp90ab1-LRP5-β-catenin pathway. Cell death and differentiation 27 35710882
2017 Thermotolerance, health profile and cellular expression of HSP90AB1 in Nguni and Boran cows raised on natural pastures under tropical conditions. Journal of thermal biology 25 29037409
2022 HSP90AB1 Promotes the Proliferation, Migration, and Glycolysis of Head and Neck Squamous Cell Carcinoma. Technology in cancer research & treatment 24 35929142
2014 The significance of HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in a Turkish population with non-small cell lung cancer. Anticancer research 24 24511009
2022 Capsid protein from red-spotted grouper nervous necrosis virus induces incomplete autophagy by inactivating the HSP90ab1-AKT-MTOR pathway. Zoological research 23 34904422
2023 DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress. Cancer cell international 19 37742009
2022 PI3K-activated MSC proteomes inhibit mammary tumors via Hsp90ab1 and Myh9. Molecular therapy oncolytics 17 36090473
2023 HSP90AB1 is a host factor that promotes porcine deltacoronavirus replication. The Journal of biological chemistry 16 38092149
2022 Capecitabine Regulates HSP90AB1 Expression and Induces Apoptosis via Akt/SMARCC1/AP-1/ROS Axis in T Cells. Oxidative medicine and cellular longevity 16 35368874
2024 SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 15 38992961
2015 Identification of SNP in HSP90AB1 and its association with the relative thermotolerance and milk production traits in Indian dairy cattle. Animal biotechnology 15 25153455
2024 circTP63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway. Science China. Life sciences 14 39754006
2018 Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance). Clinical cancer research : an official journal of the American Association for Cancer Research 14 29871907
2018 Targets Fishing and Identification of Calenduloside E as Hsp90AB1: Design, Synthesis, and Evaluation of Clickable Activity-Based Probe. Frontiers in pharmacology 14 29875664
2022 A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection. International journal of molecular sciences 12 35328701
2023 Smad3-mediated lncRNA HSALR1 enhances the non-classic signalling pathway of TGF-β1 in human bronchial fibroblasts by binding to HSP90AB1. Clinical and translational medicine 11 37317677
2021 Effect of HSP90AB1 and CC domain interaction on Bcr-Abl protein cytoplasm localization and function in chronic myeloid leukemia cells. Cell communication and signaling : CCS 11 34217296
2023 HSP90AB1 as the Druggable Target of Maggot Extract Reverses Cisplatin Resistance in Ovarian Cancer. Oxidative medicine and cellular longevity 10 37180757
2023 Dissecting the functional significance of HSP90AB1 and other heat shock proteins in countering glioblastomas and ependymomas using omics analysis and drug prediction using virtual screening. Neuropeptides 10 37729687
2022 Maggot Extract Inhibits Cell Migration and Tumor Growth by Targeting HSP90AB1 in Ovarian Cancer. Journal of clinical medicine 10 36362498
2024 GLCCI1 alleviates GRP78-initiated endoplasmic reticulum stress-induced apoptosis of retinal ganglion cells in diabetic retinopathy by upregulating and interacting with HSP90AB1. Scientific reports 9 39496608
2022 Gallic acid has an inhibitory effect on skin squamous cell carcinoma and acts on the heat shock protein HSP90AB1. Gene 9 36375658
2023 CDK1-SRC Interaction-Dependent Transcriptional Activation of HSP90AB1 Promotes Antitumor Immunity in Hepatocellular Carcinoma. Journal of proteome research 8 37949475
2023 PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer. Journal of translational medicine 7 37415147
2025 The N6-methyladenosine reader IGF2BP3 promotes bladder cancer progression through enhancing HSP90AB1 expression. The FEBS journal 6 40105114
2025 Identification of Bruceine A as a novel HSP90AB1 inhibitor for suppressing hepatocellular carcinoma growth. Journal of advanced research 6 40664262
2014 Down-regulation of heat shock protein HSP90ab1 in radiation-damaged lung cells other than mast cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 6 24670792
2020 A method to measure the denatured proteins in the corona of nanoparticles based on the specific adsorption of Hsp90ab1. Nanoscale 5 32696774
2010 Basic characterization of 90 kDa heat shock protein genes HSP90AA1, HSP90AB1, HSP90B1 and TRAP1 expressed in Japanese quail (Coturnix japonica). Animal science journal = Nihon chikusan Gakkaiho 5 20662823
2025 LGR5 interacts with HSP90AB1 to mediate enzalutamide resistance by activating the WNT/β-catenin/AR axis in prostate cancer. Chinese medical journal 4 40280884
2025 Self-Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 4 41114929
2022 Targeting the lncMST-EPRS/HSP90AB1 complex as novel therapeutic strategy for T-2 toxin-induced growth retardation. Ecotoxicology and environmental safety 4 36332407
2023 HSP90AB1 Is a Host Factor Required for Transmissible Gastroenteritis Virus Infection. International journal of molecular sciences 3 37958953
2021 Ovarian Serous Carcinoma With a Novel HSP90AB1 Mutation in a Patient With Synchronous Primary Fallopian Tube Serous Carcinoma. Anticancer research 3 34475063
2025 HNRNPH1 promotes autophagy to inhibit the development of lung adenocarcinoma via the HSP90AB1/MAP1LC3B axis. Respiratory research 2 40468317
2023 A minimal region of the HSP90AB1 promoter is suitable for ubiquitous expression in different somatic tissues with applicability for gene therapy. Frontiers in molecular biosciences 2 37138658
2026 Polydatin attenuates LPS-induced acute lung injury in rats via targeting HSP90AB1. Journal of ethnopharmacology 1 41707809
2025 Chemerin-stimulated HSP90AB1 SUMOylation promotes monocyte activation and ERK1/2 phosphorylation via β2 integrin. Cellular signalling 1 40744335
2025 Computational discovery and validation of 4'-O-methylochnaflavone as a novel HSP90AB1 inhibitor for hepatocellular carcinoma treatment. Molecular diversity 1 41073620
2025 Anti PD-L1 immunotherapy alters macrophage phenotypes via EGR1 and HSP90AB1 supported by integrated methodologies. Scientific reports 1 41125697
2025 LINC01214 Promotes Non-Small Cell Lung Cancer Through the miR-497-3p/HSP90AB1 Axis. Canadian respiratory journal 1 41209079
2025 Interaction of circPcmtd1 with HSP90AB1 mediates phosphorylation of AKT to regulate pulmonary arterial hypertension induced by high pulmonary blood flow in rat. Clinical and experimental hypertension (New York, N.Y. : 1993) 1 41264529
2024 Potentials of single nucleotide polymorphisms and genetic diversity studies at HSP90AB1 gene in Nigerian White Fulani, Muturu, and N'Dama cattle breeds. Tropical animal health and production 1 38267723
2026 Hypoxic Reprogramming of ACOX1-Driven HSP90AB1 Crotonylation Stabilizes Thioredoxin to Orchestrate Redox Homeostasis in Oral Squamous Cell Carcinoma. Research (Washington, D.C.) 0 41675575
2026 HSP90AB1-Mediated Ubiquitin-Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress-Induced Autophagy. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 41697125
2026 Puerarin and DHEA combination therapy alleviates primary dysmenorrhea via inhibition of the Hsp90ab1/p38/JNK pathway. Molecular immunology 0 42030694
2026 Zingerone Inhibits ox-LDL-Induced Human Coronary Artery Endothelial Cells Senescence and Apoptosis in Association With Downregulation of HSP90AB1 in Coronary Artery Atherosclerotic Heart Disease. Journal of biochemical and molecular toxicology 0 42262456
2025 Dehydroepiandrosterone ameliorates primary dysmenorrhea by suppressing the SP1/Hsp90ab1/COX-2 signaling pathway. Bioorganic chemistry 0 39914036
2025 Molecular characterization of the medaka (Oryzias latipes) Hsp90ab1. Fish & shellfish immunology 0 40902869
2025 Fei Wei formula attenuates pulmonary fibrosis by inhibiting lactate-driven endothelial mesenchymal transition via its target of HSP90ab1. Phytomedicine : international journal of phytotherapy and phytopharmacology 0 41192255
2025 Alantolactone curbs the malignant progression of bladder cancer partly via the HSP90AB1/LRP5/β-catenin axis. Mammalian genome : official journal of the International Mammalian Genome Society 0 41436627
2003 Chromosomal mapping of HSPCB and MYL1 expressed abundantly in the bovine fetus. Animal biotechnology 0 12887182

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