Affinage

ITGBL1

Integrin beta-like protein 1 · UniProt O95965

Length
494 aa
Mass
53.9 kDa
Annotated
2026-04-28
100 papers in source corpus 17 papers cited in narrative 17 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ITGBL1 is a secreted extracellular protein containing ten tandem integrin β-like EGF repeats that functions as a modulator of integrin signaling, extracellular matrix remodeling, and intercellular communication across developmental, fibrotic, immune, and neoplastic contexts (PMID:10051402, PMID:30305454, PMID:33413419). ITGBL1 physically interacts with cell-surface integrins to downregulate their activity, preferentially at the trailing edge of migrating cells to promote focal adhesion disassembly and directional migration, and this integrin-inhibitory function underlies its role in chondrogenesis and cartilage protection against osteoarthritis (PMID:30305454, PMID:35066808). Transcriptionally activated by RUNX2 and epigenetically regulated by SMYD3-dependent H3K4 trimethylation, ITGBL1 signals through TGFβ/Smad, NF-κB (via TNFAIP3), Wnt/PCP, and AKT pathways to drive fibroblast activation, fibrosis, epithelial-mesenchymal transition, and cancer metastasis, while also suppressing NK cell cytotoxicity to facilitate tumor immune evasion (PMID:26060017, PMID:32139701, PMID:37192621, PMID:33413419). Delivery of ITGBL1 via tumor-derived extracellular vesicles activates fibroblasts in distant organs through TNFAIP3-mediated NF-κB signaling, establishing a pre-metastatic niche that promotes colorectal cancer metastasis (PMID:32139701).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1999 High

    The molecular identity of ITGBL1 was established as a novel secreted protein with ten integrin β-like EGF repeats, providing the structural basis for its predicted integrin-related function.

    Evidence cDNA cloning from fetal lung, HUVEC, and osteoblast libraries with full domain analysis

    PMID:10051402

    Open questions at the time
    • No functional assay performed
    • Binding partners and biological role unknown
    • Expression pattern across tissues not systematically characterized
  2. 2015 High

    ITGBL1 was placed into a cancer metastasis pathway as a RUNX2 transcriptional target that activates TGFβ signaling to promote bone metastasis, establishing its first mechanistic link to tumor progression.

    Evidence Mouse bone metastasis model with RUNX2 knockdown/overexpression and TGFβ pathway reporter assays in breast cancer cells

    PMID:26060017

    Open questions at the time
    • Direct RUNX2 binding to ITGBL1 promoter not shown by ChIP at this stage
    • TGFβ pathway activation mechanism (direct vs. indirect) unresolved
    • Role of ITGBL1 in non-bone metastatic sites not tested
  3. 2015 Medium

    A context-dependent role for ITGBL1 emerged when knockdown in NSCLC promoted rather than inhibited migration, linking ITGBL1 to Wnt/PCP pathway modulation and raising the question of tissue-specific directionality of its effects.

    Evidence siRNA knockdown and recombinant protein treatment with Wnt/PCP reporter assays in lung cancer cell lines

    PMID:26307393

    Open questions at the time
    • Opposite effects in lung vs. breast cancer not mechanistically explained
    • miR-576-5p regulation not validated in vivo
    • Single lab finding
  4. 2016 Medium

    ITGBL1 was shown to activate Wnt/PCP and FAK/SRC signaling in ovarian cancer, extending its pathway repertoire beyond TGFβ and establishing it as a multi-pathway extracellular modulator.

    Evidence Gain- and loss-of-function assays with recombinant protein treatment and Western blot pathway analysis in ovarian cancer cells

    PMID:27261588

    Open questions at the time
    • Mechanism linking secreted ITGBL1 to intracellular Wnt/PCP activation unknown
    • No integrin interaction data in this system
    • Single lab
  5. 2018 High

    The long-predicted integrin interaction was directly demonstrated: ITGBL1 physically binds integrins and downregulates their activity, and this mechanism was shown to promote chondrogenesis and protect against osteoarthritis in vivo, establishing the first non-cancer physiological role.

    Evidence Co-immunoprecipitation/pulldown of ITGBL1 with integrins, gain/loss-of-function in chondrocytes, destabilized medial meniscus OA mouse model with recombinant protein rescue

    PMID:30305454

    Open questions at the time
    • Specific integrin subunit(s) mediating the interaction not defined
    • Structural basis of integrin inhibition unknown
    • Whether integrin inhibition is the sole mechanism in cancer contexts untested
  6. 2018 Medium

    Epigenetic regulation of ITGBL1 transcription was revealed through a lncRNA (lncITPF)/hnRNP-L axis that controls histone acetylation at the ITGBL1 promoter downstream of TGFβ1-Smad2/3, linking ITGBL1 to fibrosis.

    Evidence ChIP-qPCR, RNA pulldown with LC-MS, RIP, and luciferase assays in fibroblasts

    PMID:30528088

    Open questions at the time
    • lncITPF mechanism validated in one fibrotic context only
    • Relative contribution of lncITPF vs. RUNX2 to ITGBL1 expression unclear
    • No in vivo fibrosis model in this study
  7. 2020 High

    A new mode of ITGBL1 action was uncovered: tumor-derived extracellular vesicles deliver ITGBL1 to distant organs where it activates fibroblasts via TNFAIP3-mediated NF-κB signaling, establishing pre-metastatic niches for colorectal cancer.

    Evidence EV isolation and characterization, NF-κB pathway reporters/inhibitors, ITGBL1 knockdown/overexpression, in vivo CRC metastasis mouse model

    PMID:32139701

    Open questions at the time
    • How ITGBL1 is selectively sorted into EVs unknown
    • Whether EV-delivered ITGBL1 also inhibits integrins in recipient cells untested
    • Specific TNFAIP3 activation mechanism by ITGBL1 not defined
  8. 2021 High

    ITGBL1 was identified as a secreted immunomodulator that suppresses NK cell cytotoxicity, with the MITF→RUNX2→ITGBL1 transcriptional axis controlling tumor immune evasion in melanoma.

    Evidence In vitro NK cytotoxicity assays, in vivo mouse melanoma models, MITF/RUNX2 knockdown/overexpression, vitamin D3 treatment

    PMID:33413419

    Open questions at the time
    • Receptor on NK cells through which ITGBL1 acts not identified
    • Whether ITGBL1 modulates other immune cell types beyond NK cells unknown
    • Mechanism of NK suppression (integrin-dependent or independent) not determined
  9. 2022 Medium

    The subcellular mechanism of ITGBL1's integrin inhibition was refined: ITGBL1 preferentially acts at trailing edges to promote focal adhesion disassembly, explaining how it enables directional cell migration.

    Evidence Live imaging with membrane-GFP, immunostaining of active integrins/FAK/vinculin in chondrocytes after siRNA knockdown and overexpression

    PMID:35066808

    Open questions at the time
    • Mechanism of trailing-edge specificity unknown
    • Whether polarized secretion or local integrin binding explains asymmetry untested
    • Validated only in chondrocyte/ATDC5 system
  10. 2023 High

    A second epigenetic layer was uncovered: mechanical pressure suppresses ITGBL1 through integrin β1/ILK→TCF-4→SMYD3 signaling that reduces H3K4me3 at the ITGBL1 promoter, linking mechanotransduction to ITGBL1-dependent fibrosis and scar formation.

    Evidence ChIP for H3K4me3 at ITGBL1 promoter, SMYD3 knockdown in mouse scar model, clinical specimens

    PMID:37192621

    Open questions at the time
    • Relative contribution of SMYD3-H3K4me3 vs. RUNX2 to ITGBL1 transcription in fibrosis not quantified
    • Whether mechanical regulation operates in tumor contexts unknown
  11. 2025 High

    Direct RUNX2 binding to the ITGBL1 promoter was confirmed by ChIP, and the RUNX2/ITGBL1 axis was extended to hepatic stellate cell activation and HBV-driven liver fibrosis, unifying the transcriptional and fibrotic models.

    Evidence ChIP, luciferase reporter assays, RUNX2 inhibitor treatment (vitamin D3, CADD522), in vivo HBV mouse model

    PMID:40287769

    Open questions at the time
    • Whether ITGBL1 acts through integrin inhibition or TGFβ/NF-κB in stellate cell activation unclear
    • RUNX2-independent transcriptional regulation not mapped genome-wide

Open questions

Synthesis pass · forward-looking unresolved questions
  • The receptor or binding interface on target cells through which secreted ITGBL1 activates downstream NF-κB, TGFβ, and AKT signaling — and whether these all require integrin binding — remains undefined; no structural model of the ITGBL1–integrin complex exists.
  • No crystal structure or cryo-EM of ITGBL1 alone or in complex
  • Identity of specific integrin heterodimers bound by ITGBL1 not systematically tested
  • Physiological role during normal development beyond chondrogenesis not characterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005576 extracellular region 4 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-1474244 Extracellular matrix organization 2 R-HSA-5653656 Vesicle-mediated transport 2 R-HSA-168256 Immune System 1
Partners
FBLN2JDP2MITFRUNX2SMYD3TNFAIP3

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 ITGBL1 (TIED) encodes a secreted/extracellular protein with ten tandem EGF-like repeats homologous to the cysteine-rich stalk region of integrin β subunits, with a signal peptide and no transmembrane domain, mapping to chromosome 13q33. cDNA cloning and sequencing from fetal lung, HUVEC, and osteoblast libraries; structural domain analysis Genomics High 10051402
2015 ITGBL1 promotes breast cancer bone metastasis by activating the TGFβ signaling pathway as a downstream effector, and is transcriptionally driven by the upstream activator RUNX2. In vivo mouse bone metastasis model, in vitro experiments, mechanistic pathway analysis (Western blot, reporter assays), RUNX2 knockdown/overexpression Cancer research High 26060017
2018 ITGBL1 is a secreted protein that physically interacts with integrins at the cell surface to down-regulate integrin activity, thereby promoting chondrogenesis; ectopic ITGBL1 expression protected cartilage against osteoarthritis in a mouse model. Protein interaction (pulldown/co-IP of ITGBL1 with integrins), loss-of-function and gain-of-function in chondrocytes, destabilization of medial meniscus mouse OA model, recombinant protein treatment Science translational medicine High 30305454
2020 Primary colorectal cancer tumors release ITGBL1-enriched extracellular vesicles (EVs) into circulation; these EVs activate resident fibroblasts in remote organs by stimulating the TNFAIP3-mediated NF-κB signaling pathway, inducing pro-inflammatory cytokines (IL-6, IL-8) to form a pre-metastatic niche. EV isolation and characterization, co-culture experiments, NF-κB pathway inhibitors/reporters, ITGBL1 knockdown/overexpression, in vivo CRC metastasis mouse model Nature communications High 32139701
2016 ITGBL1 promotes ovarian cancer cell migration and adhesion by activating Wnt/PCP signaling and the FAK/SRC pathway. Loss- and gain-of-function assays, recombinant ITGBL1 protein treatment, Western blot for pathway activation, transwell migration assays Biomedicine & pharmacotherapy Medium 27261588
2015 Knockdown of ITGBL1 in NSCLC cell lines promotes cancer cell migration and invasion, while recombinant ITGBL1 protein inhibits migration/invasion; ITGBL1 loss enhances Wnt/PCP signaling activity and is associated with epigenetic silencing via miR-576-5p. siRNA knockdown, recombinant protein treatment, Wnt/PCP pathway reporter assays, transwell invasion assay Tumour biology Medium 26307393
2018 The lncRNA lncITPF, whose fibrotic function depends on its host gene ITGBL1, regulates H3 and H4 histone acetylation at the ITGBL1 promoter by targeting heterogeneous nuclear ribonucleoprotein L (hnRNP-L); TGF-β1-Smad2/3 is the upstream inducer binding to the lncITPF promoter. ChIP-qPCR, CRISPR-Cas9, RNA pulldown + LC-MS, RIP, luciferase assays, promoter activity analysis Molecular therapy Medium 30528088
2019 ITGBL1 promotes EMT, invasion, and migration in prostate cancer cells by activating the NF-κB signaling pathway. Overexpression and knockdown in PCa cell lines, Western blot for NF-κB pathway activation, transwell invasion/migration assays, in vivo xenograft OncoTargets and therapy Medium 31190876
2020 ITGBL1 promotes hepatocellular carcinoma cell migration and invasion by stimulating the TGF-β/Smad signaling pathway along with KRT17 and EMT-associated genes. Overexpression and knockout of ITGBL1, Western blot (TGF-β/Smad pathway), transwell assay, xenograft and orthotopic mouse models Cell proliferation Medium 32537856
2021 ITGBL1 is a secreted immunomodulator that inhibits NK cell cytotoxicity against melanoma cells; MITF transcriptionally represses ITGBL1 by inhibiting RUNX2, an activator of ITGBL1 transcription; VitaminD3 (a RUNX2 inhibitor) reverses ITGBL1-mediated immune escape. In vitro NK cytotoxicity assays, in vivo mouse models, MITF/RUNX2 overexpression/knockdown, ITGBL1 recombinant protein treatment, anti-PD1 combination experiments Molecular cancer High 33413419
2022 ITGBL1 preferentially inhibits integrin activity at the trailing edge of migrating cells, promoting focal adhesion disassembly at trailing edges and thereby facilitating directional cell migration; ITGBL1 depletion causes increased focal adhesions at trailing membrane traces preventing retraction. siRNA knockdown and overexpression in human chondrocytes/ATDC5 cells, wound healing assay, live imaging with membrane-GFP, immunostaining of active integrin/FAK/Vinculin Genes & genomics Medium 35066808
2022 ITGBL1 promotes dermal fibroblast activity (proliferation, migration, collagen synthesis) via activation of the TGFβ1-SMAD2/3 pathway; ITGBL1 protein in small extracellular vesicles from dermal fibroblasts mediates this effect and increases skin thickness in vivo. SEV isolation, LC-MS/MS protein identification, ITGBL1 overexpression in fibroblasts, Western blot (TGFβ1-SMAD2/3 pathway), in vivo mouse skin injection model Journal of nanobiotechnology Medium 35733144
2023 Mechanical pressure promotes myofibroblast dedifferentiation via the integrin β1/ILK pathway, which decreases TCF-4 and subsequently reduces SMYD3 expression, leading to decreased H3K4 trimethylation at the ITGBL1 promoter and suppressed ITGBL1 expression, resulting in scar reduction. Clinical specimen analysis, ChIP for H3K4me3 at ITGBL1 promoter, SMYD3 knockdown in mouse scar model, Western blot for ILK/TCF-4/SMYD3 pathway Developmental cell High 37192621
2025 RUNX2 directly binds to the ITGBL1 promoter and enhances its expression in HBV-infected hepatocytes; this RUNX2/ITGBL1 axis promotes hepatic stellate cell activation and liver fibrosis; inhibition of RUNX2 with Vitamin D3 or CADD522 reduces ITGBL1 levels and blocks stellate cell activation. ChIP, luciferase reporter assays, Western blot, RUNX2 inhibitor treatment, in vivo HBV mouse model Virology journal High 40287769
2024 ITGBL1 promotes anoikis resistance and metastasis in gastric cancer via the AKT/Fibulin-2 (FBLN2) axis; AKT/FBLN2 signaling inhibition reverses the pro-metastatic effects of ITGBL1 overexpression. ITGBL1 overexpression/knockdown in GC cells, anoikis resistance assays, in vitro and in vivo metastasis assays, AKT inhibitor treatment, Western blot Journal of cellular and molecular medicine Medium 38332530
2022 ITGBL1 promotes pancreatic cancer progression through the TGF-β/Smad pathway; the transcription factor JDP2 directly inhibits ITGBL1 promoter activity as shown by dual-luciferase assay. Dual-luciferase reporter assay, gain/loss-of-function experiments, Western blot for TGF-β/Smad pathway Brazilian journal of medical and biological research Medium 35584452
2021 ITGBL1 overexpression promotes gastric cancer cell proliferation and invasion via activation of the AKT signaling pathway (increased Akt phosphorylation); silencing ITGBL1 reduces Akt phosphorylation, cell mobility, and proliferation. ITGBL1 overexpression and shRNA knockdown in GC cell lines, Western blot for p-Akt, cell mobility and proliferation assays Frontiers in bioscience Low 33049688

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer cell 547 19573813
2005 New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS genetics 432 16103914
2020 Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation. Nature communications 219 32139701
2010 Extracellular BMP-antagonist regulation in development and disease: tied up in knots. Trends in cell biology 199 20188563
1996 Rapamycin resistance tied to defective regulation of p27Kip1. Molecular and cellular biology 193 8943329
2013 Discovering causal pathways linking genomic events to transcriptional states using Tied Diffusion Through Interacting Events (TieDIE). Bioinformatics (Oxford, England) 153 23986566
2016 Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease. Nature communications 142 27151236
2007 Angiopoietin: a TIE(d) balance in tumor angiogenesis. Molecular cancer research : MCR 127 17634421
2017 Place cells are more strongly tied to landmarks in deep than in superficial CA1. Nature communications 120 28218283
1989 The expression of prothymosin alpha gene in T lymphocytes and leukemic lymphoid cells is tied to lymphocyte proliferation. The Journal of biological chemistry 105 2785990
2017 Polyphosphate granule biogenesis is temporally and functionally tied to cell cycle exit during starvation in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America 98 28265086
2017 The unique histidine in OSCP subunit of F-ATP synthase mediates inhibition of the permeability transition pore by acidic pH. EMBO reports 98 29217657
2000 The oligomycin axis of mitochondrial ATP synthase: OSCP and the proton channel. Journal of bioenergetics and biomembranes 89 15254386
1999 Purification and identification of an estrogen binding protein from rat brain: oligomycin sensitivity-conferring protein (OSCP), a subunit of mitochondrial F0F1-ATP synthase/ATPase. The Journal of steroid biochemistry and molecular biology 89 10215039
2015 ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway. Cancer research 86 26060017
1984 Amino acid sequence of the oligomycin sensitivity-conferring protein (OSCP) of beef-heart mitochondria and its homology with the delta-subunit of the F1-ATPase of Escherichia coli. FEBS letters 71 6229420
2021 Neutrophil Extracellular Traps Tied to Rheumatoid Arthritis: Points to Ponder. Frontiers in immunology 59 33584645
2009 Tie2 is tied at the cell-cell contacts and to extracellular matrix by angiopoietin-1. Experimental & molecular medicine 57 19293632
2018 lncITPF Promotes Pulmonary Fibrosis by Targeting hnRNP-L Depending on Its Host Gene ITGBL1. Molecular therapy : the journal of the American Society of Gene Therapy 49 30528088
2018 ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis. Science translational medicine 46 30305454
2020 The Unique Cysteine of F-ATP Synthase OSCP Subunit Participates in Modulation of the Permeability Transition Pore. Cell reports 45 32877677
2011 Spore formation in Myxococcus xanthus is tied to cytoskeleton functions and polysaccharide spore coat deposition. Molecular microbiology 45 22188356
1983 Lack of ability of trypsin-treated mitochondrial F1-ATPase to bind the oligomycin-sensitivity conferring protein (OSCP). FEBS letters 45 6225683
2019 Functional and metabolic impairment in cigarette smoke-exposed macrophages is tied to oxidative stress. Scientific reports 44 31270372
2009 Tied up in loops: positive and negative autoregulation of p53. Cold Spring Harbor perspectives in biology 44 20452957
2018 Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease. Neurobiology of disease 43 30266287
2002 ATP synthase from Saccharomyces cerevisiae: location of the OSCP subunit in the peripheral stalk region. Journal of molecular biology 43 12206777
2018 OSCP subunit of mitochondrial ATP synthase: role in regulation of enzyme function and of its transition to a pore. British journal of pharmacology 41 30291799
1999 Cloning and characterization of a novel beta integrin-related cDNA coding for the protein TIED ("ten beta integrin EGF-like repeat domains") that maps to chromosome band 13q33: A divergent stand-alone integrin stalk structure. Genomics 41 10051402
2020 ITGBL1 promotes cell migration and invasion through stimulating the TGF-β signalling pathway in hepatocellular carcinoma. Cell proliferation 35 32537856
1985 Interactions between the oligomycin sensitivity conferring protein (OSCP) and beef heart mitochondrial F1-ATPase. 1. Study of the binding parameters with a chemically radiolabeled OSCP. Biochemistry 35 2859882
2019 Transcriptomic expression profiling identifies ITGBL1, an epithelial to mesenchymal transition (EMT)-associated gene, is a promising recurrence prediction biomarker in colorectal cancer. Molecular cancer 33 30717807
2016 Extracellular matrix protein ITGBL1 promotes ovarian cancer cell migration and adhesion through Wnt/PCP signaling and FAK/SRC pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 33 27261588
2004 Sulfide consumption by mussel gill mitochondria is not strictly tied to oxygen reduction: measurements using a novel polarographic sulfide sensor. The Journal of experimental biology 33 15371475
1985 Interactions between the oligomycin sensitivity conferring protein (OSCP) and beef heart mitochondrial F1-ATPase. 2. Identification of the interacting F1 subunits by cross-linking. Biochemistry 33 2859883
2022 Jianpi Jiedu Recipe inhibits colorectal cancer liver metastasis via regulating ITGBL1-rich extracellular vesicles mediated activation of cancer-associated fibroblasts. Phytomedicine : international journal of phytotherapy and phytopharmacology 32 35381565
2015 Epigenetic downregulated ITGBL1 promotes non-small cell lung cancer cell invasion through Wnt/PCP signaling. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 31 26307393
2013 Supramolecular host-guest pseudocomb conjugates composed of multiple star polycations tied tunably with a linear polycation backbone for gene transfection. Bioconjugate chemistry 30 23682960
2012 Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases. PloS one 30 22970289
2008 Sensory response system of social behavior tied to female reproductive traits. PloS one 29 18852894
2007 How the N-terminal domain of the OSCP subunit of bovine F1Fo-ATP synthase interacts with the N-terminal region of an alpha subunit. Journal of molecular biology 28 17355883
2004 Hormone release is tied to changes in cell size in the osmoreceptive prolactin cell of a euryhaline teleost fish, the tilapia, Oreochromis mossambicus. General and comparative endocrinology 28 15242746
1986 Efficient reconstitution of mitochondrial energy-transfer reactions from depleted membranes and F1-ATPase as a function of the amount of bound oligomycin sensitivity-conferring protein (OSCP). Biochimica et biophysica acta 28 2876727
2023 The mitochondrial inhibitor IF1 binds to the ATP synthase OSCP subunit and protects cancer cells from apoptosis. Cell death & disease 27 36690622
1994 Properties of yeast cells depleted of the OSCP subunit of mitochondrial ATP synthase by regulated expression of the ATP5 gene. Biochemistry and molecular biology international 27 7866306
2020 An expanded repertoire of intensity-dependent exercise-responsive plasma proteins tied to loci of human disease risk. Scientific reports 23 32616758
1998 The assembly of yeast mitochondrial ATP synthase: subunit depletion in vivo suggests ordered assembly of the stalk subunits b, OSCP and d. Biochimica et biophysica acta 23 9630594
1984 Oligomycin sensitivity-conferring protein (OSCP) of beef heart mitochondria. Internal sequence homology and structural relationship with other proteins. FEBS letters 23 6236996
1995 Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2. Genomics 22 7490082
1985 Stoichiometry of the oligomycin-sensitivity-conferring protein (OSCP) in the mitochondrial F0F1-ATPase determined by an immunoelectrotransfer blot technique. Biochimica et biophysica acta 22 2865972
2022 Tied up in knots: Untangling substrate recognition by the SPOUT methyltransferases. The Journal of biological chemistry 21 35988649
2019 ITGBL1 promotes EMT, invasion and migration by activating NF-κB signaling pathway in prostate cancer. OncoTargets and therapy 20 31190876
1984 Monoclonal antibodies to mitochondrial F1-ATPase and oligomycin sensitivity conferring protein (OSCP). Tools for recognition of well conserved and essential antigenic sites. Biochemical and biophysical research communications 20 6206858
1997 A novel fluorescent marker for assembled mitochondria ATP synthase of yeast. OSCP subunit fused to green fluorescent protein is assembled into the complex in vivo. FEBS letters 19 9247150
1992 Oligomycin sensitivity-conferring protein (OSCP) of mitochondrial ATP synthase. The carboxyl-terminal region of OSCP is essential for the reconstitution of oligomycin-sensitive H(+)-ATPase. The Journal of biological chemistry 19 1535627
2010 Tritopic phenanthroline and pyridine tail-tied aza-scorpiands. Organic & biomolecular chemistry 18 20448894
1998 The oligomycin sensitivity conferring protein of rat liver mitochondrial ATP synthase: arginine 94 is important for the binding of OSCP to F1. Biochemistry 18 9753477
2021 ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity. Molecular cancer 17 33413419
1992 Heterologous expression, purification, and biochemistry of the oligomycin sensitivity conferring protein (OSCP) from yeast. The Journal of biological chemistry 17 1464586
1995 The functional expression of a rat cDNA encoding OSCP in the yeast Saccharomyces cerevisiae. Biochemical and biophysical research communications 16 7864899
2023 Mechanical pressure-induced dedifferentiation of myofibroblasts inhibits scarring via SMYD3/ITGBL1 signaling. Developmental cell 14 37192621
2022 Small extracellular vesicles derived from dermal fibroblasts promote fibroblast activity and skin development through carrying miR-218 and ITGBL1. Journal of nanobiotechnology 14 35733144
2019 Three novel genes tied to mandibular prognathism in eastern Mediterranean families. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 14 31256822
1984 The oligomycin sensitivity conferring protein (OSCP) of beef heart mitochondria: studies of its binding to F1 and its function. Journal of bioenergetics and biomembranes 14 6242246
2022 Rad1 and Rad10 Tied to Photolyase Regulators Protect Insecticidal Fungal Cells from Solar UV Damage by Photoreactivation. Journal of fungi (Basel, Switzerland) 13 36354891
1997 Oligomycin sensitivity conferring protein (OSCP) of bovine heart mitochondrial ATP synthase: high-affinity OSCP-Fo interactions require a local alpha-helix at the C-terminal end of the subunit. Biochemistry 13 9283085
2023 The ABI5-dependent down-regulation of mitochondrial ATP synthase OSCP subunit facilitates apple necrotic mosaic virus infection. Journal of experimental botany 12 37086216
2022 In toto imaging of early enteric nervous system development reveals that gut colonization is tied to proliferation downstream of Ret. Development (Cambridge, England) 12 36300492
2024 ITGBL1 promotes anoikis resistance and metastasis in human gastric cancer via the AKT/FBLN2 axis. Journal of cellular and molecular medicine 11 38332530
2021 Functional Genomics of PRUNE1 in Neurodevelopmental Disorders (NDDs) Tied to Medulloblastoma (MB) and Other Tumors. Frontiers in oncology 11 34745995
2017 Periplasmic Binding Protein Dimer Has a Second Allosteric Event Tied to Ligand Binding. Biochemistry 11 28876049
2015 Heterogeneous side chain conformation highlights a network of interactions implicated in hysteresis of the knotted protein, minimal tied trefoil. Journal of physics. Condensed matter : an Institute of Physics journal 11 26291198
2011 Tied down: tethering redox proteins to the outer membrane in Neisseria and other genera. Biochemical Society transactions 11 22103547
2020 Regulatory Mechanism of ITGBL1 in the Metastasis of Colorectal Cancer. Frontiers in oncology 9 32211321
2020 Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer's pathology. Neurobiology of aging 9 33254080
2019 Red-Brown Pigmentation of Acidipropionibacterium jensenii Is Tied to Haemolytic Activity and cyl-Like Gene Cluster. Microorganisms 9 31671651
2014 Dioxins contamination in the feed additive (feed grade cupric sulfate) tied to chlorine industry. Scientific reports 8 25102073
2020 Evaluation of the Role of ITGBL1 in Ovarian Cancer. Cancers 7 32961775
2010 An RNA end tied to the cell cycle: new ties to apoptosis and microRNA formation? Cell cycle (Georgetown, Tex.) 7 20234174
2024 The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1. Alzheimer's & dementia : the journal of the Alzheimer's Association 6 39559858
2024 Flavonoids regulate LDLR through different mechanisms tied to their specific structures. Journal of lipid research 5 38556050
2021 ITGBL1 promotes gastric cancer cell proliferation and invasion via Akt signal pathway. Frontiers in bioscience (Landmark edition) 5 33049688
1989 Epitope of OSCP oligomycin sensitivity conferring protein exposed at the surface of the mitochondrial ATPase-ATPsynthase complex. Biochimie 5 2478197
1987 A fluorescent derivative of the oligomycin-sensitivity conferring protein (acrylodan-OSCP). Evidence for polarity changes in the environment of CYS118 of OSCP upon binding to mitochondrial F1. Biochemical and biophysical research communications 5 2880585
2025 Aggregate index of systemic inflammation tied to increased fatty liver disease risk: insights from NHANES data. BMC gastroenterology 4 40410700
2023 Changes in dairy cows' behaviour, health, and production after transition from tied to loose housing. Acta veterinaria Scandinavica 4 37391805
2023 Unveiling OSCP as the potential therapeutic target for mitochondrial dysfunction-related diseases. Life sciences 4 38030056
1989 Plant mitochondrial F1-ATPase. The presence of oligomycin-sensitivity-conferring protein (OSCP). The Biochemical journal 4 2532502
2022 Integrin β-like 1 protein (ITGBL1) promotes cell migration by preferentially inhibiting integrin-ECM binding at the trailing edge. Genes & genomics 3 35066808
2022 ITGBL1 transcriptionally inhibited by JDP2 promotes the development of pancreatic cancer through the TGF-beta/Smad pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 3 35584452
2020 How autophagy is tied to inflammation and cancer. Molecular & cellular oncology 3 32158928
2020 Treating a Patient with Your Hands Tied: Acute Chest Syndrome in a Jehovah's Witness. Cureus 3 32461845
2010 Drought stress signals in modern and subfossil Quercus laurifolia (Fagaceae) leaves reflect winter precipitation in southern Florida tied to El Nino-Southern Oscillation activity. American journal of botany 3 21622441
2005 Glycoprotein hormones tied but not tethered like other cysteine-knot cytokines. Trends in pharmacological sciences 3 16054241
2025 Viremic non-progression in HIV/SIV infection: A tied game between virus and host. Cell reports. Medicine 2 39842407
2018 Tied up: Does altering phosphoinositide-mediated membrane trafficking influence neurodegenerative disease phenotypes? Journal of genetics 2 30027907
2025 HBV activates hepatic stellate cells through RUNX2/ITGBL1 axis. Virology journal 1 40287769
2025 Signs of Alzheimer's Disease: Tied to Aging. International journal of molecular sciences 1 40507786
2024 IP3Rs and nSOCE-Tied Together at Two Ends. Contact (Thousand Oaks (Ventura County, Calif.)) 1 38356482
2022 Model spread in tropical low cloud feedback tied to overturning circulation response to warming. Nature communications 1 36402770