Affinage

ITGB1

Integrin beta-1 · UniProt P05556

Length
798 aa
Mass
88.4 kDa
Annotated
2026-06-10
100 papers in source corpus 36 papers cited in narrative 36 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ITGB1 (CD29, β1 integrin) is a transmembrane adhesion receptor that mediates cell attachment to extracellular matrix proteins—collagen, laminin, and fibronectin—and translates engagement into intracellular signaling that governs adhesion, migration, survival, and tumor progression (PMID:7547709). As a β subunit it heterodimerizes with α partners (VLA-4/CD49d and VLA-5/CD49e) to drive integrin-dependent leukocyte costimulation and recruitment (PMID:1383369, PMID:11254723), and its adhesive output is amplified within surface co-receptor complexes containing CD38, CD98, CD147, CD63, CD248, and PD-L1 (PMID:22289918, PMID:27610038, PMID:30635444, PMID:36997926, PMID:37386737). The dominant downstream module is FAK/Src signaling, which—together with PI3K/AKT, ILK, MEK/ERK, NF-κB and MAPK arms—is activated by ECM-derived and matricellular ligands including TIMP-1, periostin, THBS4, SPARCL1, COL10A1, GMFG and MUC5AC, and confers proliferation, EMT, radioresistance, and chemoresistance in multiple cancers (PMID:30635444, PMID:32567740, PMID:32781616, PMID:38866293, PMID:25805567, PMID:33613118). ITGB1 abundance is set transcriptionally by SOX10, which cooperates with β1 integrin to guide enteric neural crest cell migration (PMID:23608456), and post-transcriptionally by an m6A axis in which ALKBH5 erasure and IGF2BP1 reading stabilize ITGB1 mRNA while YTHDF2 reading drives its degradation (PMID:36632222, PMID:34098071, PMID:39891203). ITGB1 surface activity is further tuned by dynamin-dependent trafficking and by integrin-associated regulators that feed back on FAK/AKT signaling (PMID:30538113, PMID:31395336). In the immune system, β1 integrin controls T-cell signaling and CNS entry of dendritic cells, and galectin-3 binding to CD29 triggers mitochondrial T-cell apoptosis (PMID:31318439, PMID:14678989).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1993 Medium

    Established that CD29 engagement is not merely structural but feeds into T-cell signaling, by showing antibody ligation modulates lipid second-messenger metabolism during CD3 activation.

    Evidence Phospholipid metabolite measurement and proliferation/IL-2 rescue assays in Jurkat and primary CD4+ T cells

    PMID:7686929

    Open questions at the time
    • Antibody ligation may not mimic physiological ECM engagement
    • No defined α partner or downstream kinase identified
    • Mechanism linking integrin to DAG/PA changes unresolved
  2. 1995 Medium

    Defined the core adhesive function of β1 integrin—binding collagen, laminin and fibronectin—and its contribution to T-cell proliferation alongside LFA-1.

    Evidence mAb generation, immunoprecipitation, adhesion blocking and proliferation assays in mouse

    PMID:7547709

    Open questions at the time
    • Did not resolve which αβ1 heterodimers bind which ligands
    • No intracellular signaling mechanism
    • Costimulation role inferred from combined blockade
  3. 2003 Medium

    Showed CD29 can act as a death-signaling receptor in T cells, with galectin-3 binding triggering the mitochondrial apoptotic pathway in a glycan-dependent manner.

    Evidence Carbohydrate-inhibition binding, co-IP and apoptosis readouts (cytochrome c, caspase-3)

    PMID:14678989

    Open questions at the time
    • Direct vs. indirect coupling of CD29 to mitochondria not defined
    • Caspase-8 independence leaves upstream trigger unclear
    • Single lab
  4. 2012 High

    Demonstrated that β1 integrin adhesive output is modulated within surface co-receptor complexes, as CD38 associates with CD49d/CD29 and enhances adhesion and survival in CLL.

    Evidence Reciprocal co-IP, co-capping, CD38-transfectant adhesion rescue and phospho-Vav-1 analysis

    PMID:22289918

    Open questions at the time
    • Stoichiometry and structural basis of the complex unknown
    • Whether CD38 alters integrin conformation directly untested
  5. 2011 High

    Connected CD29 engagement to pro-survival signaling, showing it drives a NOX2-dependent ROS burst that activates MEK/ERK and PI3K/Akt in cardiomyocytes.

    Evidence ROS flow cytometry, NOX activity assay, NOX2-knockout cardiomyocytes and antioxidant overexpression

    PMID:22198504

    Open questions at the time
    • Link between integrin clustering and NOX2 activation undefined
    • Generality beyond cardiomyocytes untested
  6. 2013 High

    Placed ITGB1 under transcriptional control of SOX10 and showed a cooperative genetic requirement for enteric neural crest cell migration in vivo.

    Evidence Mouse genetic epistasis with double mutants and live-imaging of neural crest migration

    PMID:23608456

    Open questions at the time
    • Direct SOX10 binding to ITGB1 regulatory regions not shown
    • Migration defect mechanism (speed vs directionality) only partly resolved
  7. 2019 High

    Identified a TIMP-1/CD63/ITGB1/FAK signaling cascade controlling dendritic cell motility, defining a defined ligand-receptor route into integrin signaling.

    Evidence shRNA silencing of multiple components, antibody blockade and FAK/SRC/PI3K inhibition with live-cell migration

    PMID:30635444

    Open questions at the time
    • Whether TIMP-1/CD63 engages ITGB1 directly or via clustering unclear
    • α partner not specified
  8. 2020 High

    Established m6A control of ITGB1 mRNA, with ALKBH5 demethylation antagonizing YTHDF2-mediated decay to elevate ITGB1 and FAK/Src signaling and drive metastasis.

    Evidence RNA pulldown, RIP/MeRIP-qPCR, luciferase reporter and in vivo ovarian cancer models

    PMID:36632222

    Open questions at the time
    • Site-specific m6A residues on ITGB1 not fully mapped
    • How upstream signals set ALKBH5/YTHDF2 balance unknown
  9. 2021 Medium

    Extended m6A regulation by showing a KAT1→YTHDF2 axis represses ITGB1 and downstream FAK/PI3K/AKT, with disease relevance in diabetic retinopathy.

    Evidence Histone acetylation and promoter reporter assays, sh-YTHDF2/sh-ITGB1 knockdown and STZ mouse model

    PMID:34098071

    Open questions at the time
    • Direct KAT1 occupancy at YTHDF2 promoter inferred
    • Generality of the axis beyond retina untested
  10. 2025 Medium

    Implicated the m6A reader IGF2BP1 in ITGB1 stabilization via phase separation, broadening the post-transcriptional control network in chemoresistance.

    Evidence circRNA co-IP, ubiquitination and phase-separation assays with cisplatin-resistance models

    PMID:39891203

    Open questions at the time
    • Direct IGF2BP1 binding to ITGB1 transcript vs indirect effect not fully separated
    • Role of phase separation in mRNA stability mechanistically unresolved
  11. 2023 High

    Revealed an immune-checkpoint cross-talk in which PD-L1 directly binds ITGB1 to activate NF-κB and confer chemoresistance, with USP51 stabilizing PD-L1.

    Evidence Pulldown, SPR, co-IP, deubiquitination assay and mouse models

    PMID:37386737

    Open questions at the time
    • Binding interface on ITGB1 not mapped
    • Whether interaction alters integrin adhesion function untested
  12. 2024 Medium

    Expanded the matricellular ligand repertoire, showing COL10A1 and GMFG directly bind ITGB1 to activate PI3K/AKT and promote tumor progression.

    Evidence Co-IP, knockdown/rescue and in vivo tumor and metastasis models

    PMID:38866293 PMID:39207055

    Open questions at the time
    • Binding sites and α partner specificity undefined
    • Direct vs co-receptor-mediated binding not fully resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the many ligands, co-receptors, and m6A/transcriptional inputs are integrated into context-specific α-subunit pairing and conformational activation of ITGB1 remains unresolved.
  • No structural model of ligand/co-receptor engagement on ITGB1 in the corpus
  • α partner specificity for most ligands not defined
  • Inside-out vs outside-in activation hierarchy not mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 4 GO:0098631 cell adhesion mediator activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005886 plasma membrane 4
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-1474244 Extracellular matrix organization 3 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3
Partners
CD147CD248CD38CD63CD98COL10A1PD-L1THBS4
Complex memberships
CD29/CD98/CD147 surface complexCD49d/CD29/CD38 complexVLA-4 (CD49d/CD29 integrin)VLA-5 (CD49e/CD29 integrin)

Evidence

Reading pass · 36 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 Galectin-3 binds to CD29 (ITGB1) on the cell surface and induces T-cell apoptosis via mitochondrial pathway, including cytochrome c release and caspase-3 activation (but not caspase-8 activation), in a carbohydrate-dependent manner. Antibody blocking, lactose inhibition assay, co-immunoprecipitation, apoptosis assays (cytochrome c release, caspase activation) Cancer research Medium 14678989
1993 CD29 (ITGB1) engagement by soluble anti-CD29 mAb K20 suppresses T-cell proliferation by reducing diacylglycerol and phosphatidic acid levels in CD3-activated T cells, without affecting PIP2 hydrolysis, cytosolic Ca2+ or inositolphosphates, and independently of IL-2 receptor engagement. Phospholipid metabolite measurement (DAG, PA, PE), proliferation assay, IL-2 rescue experiment in Jurkat and primary CD4+ T cells Journal of immunology Medium 7686929
1995 Mouse CD29 (ITGB1, beta1 integrin subunit) mediates cell adhesion to extracellular matrix proteins collagen, laminin, and fibronectin; blocking CD29 in combination with anti-LFA-1 inhibits T cell proliferation induced by anti-CD3 and allogeneic MLR. mAb generation, immunoprecipitation, cell adhesion blocking assay, T-cell proliferation assay International immunology Medium 7547709
1992 ITGB1 (CD29) engagement by immobilized anti-CD49d (alpha4) mAb potentiates T-cell proliferation via anti-CD3; soluble anti-CD29 mAb inhibits this VLA-4-mediated co-stimulation of T cells. Immobilized mAb proliferation assay, soluble antibody inhibition Journal of leukocyte biology Low 1383369
2011 CD29 (ITGB1) and CD73 mediate mechanically-induced decrease in MSC migration; specific inhibition of CD29/CD73 demonstrates their substrate-dependent involvement in post-loading migration, with FAK and Src-family kinases identified as downstream targets. Mechanical loading, specific antibody inhibition, scanning electron microscopy, phalloidin staining (actin), FAK/Src kinase analysis European cells & materials Medium 21732280
2011 CD29 (ITGB1) activation in neonatal rat cardiomyocytes induces an NOX2/p47(phox)-dependent reactive oxygen species burst and activates MEK/ERK and PI3K/Akt pro-survival pathways; NOX2-deficient cardiomyocytes lose CD29-induced pro-survival signaling. Flow cytometry (ROS), lucigenin chemiluminescence (NOX activity), adenoviral overexpression of antioxidants, NOX2 knockout mouse cardiomyocytes, pharmacological inhibition Cardiovascular research High 22198504
2012 The CD49d/CD29 (ITGB1) integrin complex constitutively associates with CD38 in CLL cells; CD38 enhances CD49d/CD29-mediated cell adhesion to VCAM-1 and fibronectin substrates, with CD49d+CD38+ cells showing higher Vav-1 phosphorylation, more complex F-actin distribution at adhesion sites, and greater apoptosis resistance. Co-capping, co-immunoprecipitation, cell adhesion assay on CD49d-specific substrates, CD38 transfection, phospho-Vav-1 Western blot, F-actin staining Leukemia High 22289918
2019 TIMP-1 signals through its receptor CD63 to ITGB1 (CD29), activating FAK (and associated kinases SRC and PI3K), which drives hypermotility of Toxoplasma gondii-infected dendritic cells; shRNA silencing of ITGB1 or FAK, or antibody blockade of ITGB1, abrogated DC hypermotility. shRNA gene silencing (TIMP-1, CD63, ITGB1, FAK), antibody blockade, pharmacological inhibition of FAK/SRC/PI3K, live-cell migration assay Journal of cell science High 30635444
2013 SOX10 transcriptionally regulates beta1-integrin (ITGB1) expression; compound heterozygous Sox10/beta1-integrin mutant mice show more severe intestinal aganglionosis and enteric neural crest cell migration defects (reduced speed and altered directionality) than single mutants, establishing a cooperative genetic interaction. Mouse genetic epistasis (double mutant cross), video-microscopy of neural crest cell migration, gene expression analysis in Sox10 mutant mice Developmental biology High 23608456
2015 CD29 (ITGB1) overexpression in hepatocellular carcinoma cells activates ILK, increases Akt Ser473 phosphorylation and mTORC1 expression, induces EMT (decreased E-cadherin, increased fibronectin and vimentin), and confers resistance to radiation and cisplatin; CD29 silencing sensitizes tumors to these treatments. Adenoviral CD29 overexpression/shRNA silencing, xenograft mouse model, Western blot (ILK, Akt, EMT markers), MTT cell viability Medical oncology Medium 25805567
2018 ITGB1 is an upstream regulator of Caveolin-1 (CAV1) expression in prostate cancer cells; ITGB1 and integrin-associated proteins were identified as CAV1 regulators by rationalized RNAi screening, and CAV1 upregulation downstream of ITGB1 switches TGFβ signaling from tumor-suppressive to oncogenic. RNAi screen with high-content microscopy, gene expression correlation, quantitative multiplex imaging of clinical samples, CAV1 knockdown functional assays Scientific reports Medium 29402961
2019 TIMP-1/CD63/ITGB1/STAT3 form a feedback loop in breast cancer cells: TIMP-1 binds CD63 and cooperates with integrin β1 to activate STAT3 and ERK1/2; STAT3 in turn drives TIMP-1 expression; knockdown of any component abolishes CAF-induced migration and growth. siRNA knockdown of each component, recombinant TIMP-1 treatment, STAT3/ERK phosphorylation Western blot, migration assay with CAF conditioned medium Cancers Medium 36291767
2020 THBS4 (thrombospondin 4) physically interacts with ITGB1 (integrin β1) and activates the FAK/PI3K/AKT signaling pathway to promote HCC cell proliferation and metastasis in vitro and in vivo. Co-immunoprecipitation, Western blot, immunofluorescence, colony formation, Transwell, xenograft FASEB journal Medium 32567740
2020 ALKBH5 demethylates m6A on ITGB1 mRNA and suppresses YTHDF2-mediated m6A-dependent degradation of ITGB1 mRNA, resulting in increased ITGB1 protein, FAK and Src phosphorylation, and enhanced lymphangiogenesis and lymph node metastasis in ovarian cancer. RNA pulldown, RIP-qPCR, MeRIP-qPCR, co-IP, luciferase reporter, m6A dot blot, in vitro/in vivo functional studies Theranostics High 36632222
2021 KAT1 activates YTHDF2 transcription via histone acetylation; YTHDF2 then triggers m6A-dependent ITGB1 mRNA degradation, suppressing ITGB1 expression and downstream FAK/PI3K/AKT signaling in retinal cells, reducing diabetic retinopathy progression. Histone acetylation assay, YTHDF2 promoter reporter, sh-YTHDF2/sh-ITGB1 knockdown, Western blot (FAK/PI3K/AKT), in vivo STZ mouse model Pharmacological research Medium 34098071
2023 PD-L1 directly binds ITGB1 on NSCLC cell membranes; this PD-L1/ITGB1 interaction activates NF-κB signaling to confer chemoresistance. USP51 deubiquitinates and stabilizes PD-L1, enabling this interaction. DHM inhibits USP51, reducing PD-L1 and re-sensitizing cells to chemotherapy. Co-immunoprecipitation, pulldown assay, protein deubiquitination assay, SPR, cellular thermal shift assay, NF-κB pathway analysis, tissue microarray, mouse models Cancer communications High 37386737
2021 ITGB1 knockdown in NSCLC cells enhances radiation-induced DNA damage, increases G2/M arrest, and suppresses YAP1 expression and nuclear translocation; ITGB1 promotes radioresistance via DNA repair modulation and YAP1-induced EMT. shRNA knockdown, colony formation, flow cytometry, immunofluorescence (γH2AX), Western blot (YAP1, EMT markers) International journal of biological sciences Medium 33613118
2021 ITGB1 drives HCC progression through the ITGB1/PXN (paxillin)/YWHAZ (14-3-3ζ)/AKT axis; ITGB1 siRNA knockdown decreases PXN and YWHAZ expression, impairs HCC cell migration, drug resistance, and colony formation, and delays cell cycle progression. siRNA knockdown, Western blot, immunostaining, xenograft, cell cycle analysis Frontiers in cell and developmental biology Medium 34977001
2019 FRK (Fyn-related kinase) decreases ITGB1 expression at both mRNA and protein levels in glioma cells, suppressing FAK and AKT activity; ITGB1 overexpression partially rescues FRK-induced glioma growth suppression, positioning ITGB1 downstream of FRK in the FRK–ITGB1–FAK signaling axis. FRK overexpression, ITGB1 overexpression rescue, Western blot (ITGB1, FAK, AKT), intracranial xenograft, immunofluorescence Biochemical and biophysical research communications Medium 31395336
2020 MUC5AC physically interacts with CD44 and ITGB1 (CD29), promoting CD44/ITGB1 clustering and Rac1 activation, which drives migration of adipose-derived mesenchymal stem cells toward pancreatic tumors; pharmacological inhibition of Rac1 blocks this migration. Mass spectrometry interactome, ELISA, live-cell imaging, flow cytometry, Rac1 pharmacological inhibition, autochthonous murine PC models Gastroenterology Medium 35219699
2019 SIPA1 (GTPase-activating protein) promotes invasion and migration in oral squamous cell carcinoma through regulation of ITGB1 and MMP7; SIPA1 knockdown increases ITGB1 expression while decreasing MMP7, identifying ITGB1 as a downstream effector of SIPA1 in cancer metastasis. shRNA knockdown, Western blot, invasion/migration assay, immunohistochemistry Experimental cell research Low 28237246
2022 ITGB1 mediates DDR2-regulated periostin (POSTN) expression in ovarian cancer-associated fibroblasts; DDR2 controls periostin through ITGB1, and POSTN-ITGB1 signaling promotes mesothelial clearance and tumor invasion. Co-culture experiments, DDR2/POSTN knockdown and overexpression, tumor burden assay in mouse, functional invasion assay Cancers Medium 35884543
2018 Dynamins 2 and 3 (DNM2/DNM3) regulate ITGB1 activity in megakaryocytes; inhibition or knockdown of DNM2/DNM3, or expression of dominant-negative/GTPase-defective dynamin, diminishes ITGB1 (beta1 integrin) activity and impairs directional megakaryocyte migration toward SDF-1α gradients. DNM2/DNM3 shRNA knockdown, dominant-negative/GTPase-dead dynamin expression, ITGB1 activity assay, directional migration assay Blood advances Medium 30538113
2020 SPARCL1 physically interacts with ITGB1 (confirmed by co-immunoprecipitation and mass spectrometry); SPARCL1 promotes bovine satellite cell migration and early differentiation through ITGB1-mediated regulation of p-FAK, p-paxillin, vinculin, Cdc42, and Arp2/3. Immunoprecipitation + mass spectrometry, co-immunoprecipitation, cell scratch assay, desmin staining, Western blot (FAK, paxillin, vinculin, Cdc42, Arp2/3) Animals Medium 32781616
2022 miR-134-5p directly targets Itgb1 mRNA (confirmed by luciferase reporter assay); Itgb1 knockdown reverses miR-134-5p antagomir-promoted osteoclastogenesis; the miR-134-5p/Itgb1 axis modulates the MAPK pathway (p-p38 and p-ERK levels) to regulate osteoclast differentiation. Luciferase reporter assay, miR-134-5p agomir/antagomir transfection, Itgb1 siRNA co-transfection, OVX mouse model, MAPK pathway Western blot Journal of biological chemistry Medium 35691339
2019 ITGB1 (CD29) is required for CNS accumulation of plasmacytoid dendritic cells during EAE neuroinflammation; adoptive transfer experiments showed pDC entry into the CNS was strongly inhibited in the absence of CD29, while CD18 (β2 integrin) was not required; blocking CD49d (α4) also diminished CNS-pDC numbers. Adoptive transfer experiments, CD29-knockout pDCs, antibody blockade of CD49d, flow cytometry European journal of immunology Medium 31318439
2001 α4β1 (VLA-4, CD49d/CD29) and α5β1 (VLA-5, CD49e/CD29) integrins mediate β2-integrin-independent neutrophil recruitment to LPS-induced lung inflammation; combined blocking of α4 + β2 inhibited parenchymal PMNL accumulation by 56%, adding α5 blockade increased inhibition to 79%; α5β1 also mediates pulmonary vascular and epithelial permeability. Blocking mAb administration in Lewis rat LPS lung inflammation model, myeloperoxidase assay, BALF protein measurement Journal of immunology Medium 11254723
2024 RPS7 stabilizes LOXL2 mRNA by binding AUUUA motifs in the 3'UTR of LOXL2, increasing LOXL2 expression; LOXL2 then maintains ITGB1 protein stability and activates ITGB1-mediated FAK/SRC signaling to promote HCC metastasis. RNA-seq, RIP, RNA pulldown, dual luciferase reporter, nascent RNA capture, RNA decay assay, CRISPR-Cas9 KO, Western blot Journal of experimental & clinical cancer research High 38326908
2023 CD248 promotes the interaction between ITGB1 and ECM proteins CYR61 and fibronectin, activating the FAK-paxillin pathway and formation of focal adhesions to drive osteosarcoma migration and metastasis; CD248 knockdown inhibits lung metastasis in vivo. RNA-seq, Western blot, immunofluorescence, co-immunoprecipitation (CD248 KD cells), lung metastasis nude mouse model BMC cancer Medium 36997926
2024 COL10A1 (Type X collagen) directly interacts with ITGB1 and activates PI3K/AKT signaling to promote TNBC cell proliferation, migration, invasion, and in vivo tumor growth; knockdown of either COL10A1 or ITGB1 reverses these effects. Co-immunoprecipitation (COL10A1-ITGB1 interaction), COL10A1/ITGB1 knockdown, PI3K/AKT pathway analysis, in vivo tumor and lung metastasis models International journal of biological macromolecules Medium 38866293
2024 GMFG, a paracrine signal from ERS-CAFs (via IER2/GMFG axis), directly binds ITGB1 on tumor cells to promote chordoma progression; ITGB1 inhibition attenuates tumor malignant progression, which is partially reversed by exogenous GMFG. Single-cell RNA-seq, spatial transcriptomics, DIA proteomics, multiplexed immunofluorescence, ITGB1 inhibition with GMFG rescue experiment Advanced science Medium 39207055
2025 CircRNF13 interacts with m6A reader IGF2BP1, inhibiting its ubiquitin-mediated degradation and promoting IGF2BP1 phase separation; this increases ITGB1 mRNA stability in an m6A-dependent manner, promoting cisplatin resistance in oral cancer. circRNA expression analysis, co-IP (circRNF13–IGF2BP1), ubiquitination assay, phase separation assay, m6A modification assay, in vitro and in vivo cisplatin resistance experiments Molecular cancer Medium 39891203
2022 Maspin suppresses gastric cancer invasion and angiogenesis by blocking the ITGB1/FAK pathway; Maspin expression is negatively correlated with ITGB1 and p-FAK levels in tumor tissues; Maspin CRISPR activation plus ITGB1 siRNA increases E-cadherin and reduces Vimentin and VEGF. Immunohistochemistry (tissue), CRISPR activation, siRNA knockdown, Transwell, wound healing, tube formation assay, Western blot Human cell Medium 32409959
2023 ITGB1 overexpression activates the cAMP signaling pathway in chondrocytes, suppressing cartilage inflammation (TNF-α, IL-1β, IL-6) and apoptosis in an osteoarthritis model; a cAMP pathway inhibitor reverses the protective effects of ITGB1 overexpression. Bioinformatics, OA rat model, ITGB1 overexpression, Western blot (cAMP pathway), ELISA (cytokines), CCK-8, flow cytometry Journal of orthopaedic surgery and research Low 37941009
2009 Cell-permeable ceramides (C2- and C6-ceramide) suppress CD29 (ITGB1)-mediated monocytic U937 cell-cell and cell-fibronectin adhesion in a dose-dependent manner; C6-ceramide inhibits CD29 phosphorylation induced by MEM101A and downregulates surface levels of CD29, CD98, and CD147. Cell adhesion assay, ceramide/sphingolipid dose-response, CD29 phosphorylation Western blot, surface expression flow cytometry Immunobiology Medium 19576658
2016 CD29 (ITGB1), CD98, and CD147 form a molecular complex at the cell surface of U937 monocytes that jointly mediates cell-cell adhesion; co-IP and confocal microscopy confirm molecular association between all three molecules and the actin cytoskeleton; antibody blockade of any single component reduces adhesion similarly. Co-immunoprecipitation, confocal microscopy, aggregation-activating/blocking antibodies, enzyme inhibitor sensitivity profiling Korean journal of physiology & pharmacology Medium 27610038

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis. Cancer research 303 14678989
2009 CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells. Stem cells (Dayton, Ohio) 192 19725119
2015 Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer. Cancer science 129 26509963
1991 Expression of cytoadhesion molecules (CD56, CD54, CD18 and CD29) by myeloma plasma cells. British journal of haematology 99 1721526
2020 CD29 identifies IFN-γ-producing human CD8+ T cells with an increased cytotoxic potential. Proceedings of the National Academy of Sciences of the United States of America 97 32161126
2018 Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia. The Journal of experimental medicine 84 29301866
2017 P53-induced miR-30e-5p inhibits colorectal cancer invasion and metastasis by targeting ITGA6 and ITGB1. International journal of cancer 81 28656629
2020 THBS4 promotes HCC progression by regulating ITGB1 via FAK/PI3K/AKT pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 80 32567740
2011 CD73 and CD29 concurrently mediate the mechanically induced decrease of migratory capacity of mesenchymal stromal cells. European cells & materials 80 21732280
2012 The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells. Leukemia 77 22289918
2021 ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition. International journal of biological sciences 71 33613118
2023 ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer. Theranostics 70 36632222
2001 The alpha 4 beta 1 (very late antigen (VLA)-4, CD49d/CD29) and alpha 5 beta 1 (VLA-5, CD49e/CD29) integrins mediate beta 2 (CD11/CD18) integrin-independent neutrophil recruitment to endotoxin-induced lung inflammation. Journal of immunology (Baltimore, Md. : 1950) 68 11254723
2021 Ropivacaine inhibits the proliferation and migration of colorectal cancer cells through ITGB1. Bioengineered 57 33345684
2021 KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy. Pharmacological research 54 34098071
2012 Cancer stem-like cells enriched with CD29 and CD44 markers exhibit molecular characteristics with epithelial-mesenchymal transition in squamous cell carcinoma. Archives of dermatological research 54 22740085
1995 Identification and functional characterization of mouse CD29 with a mAb. International immunology 53 7547709
2021 Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 51 33684690
2017 Deregulation of miR-183 promotes melanoma development via lncRNA MALAT1 regulation and ITGB1 signal activation. Oncotarget 47 27966454
2016 miR-17 inhibits ovarian cancer cell peritoneal metastasis by targeting ITGA5 and ITGB1. Oncology reports 47 27499367
2015 Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2. Scientific reports 43 26611568
2013 Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma. Urologic oncology 42 23499501
1994 Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation. European journal of immunology 41 8020569
2021 ITGB1-DT Facilitates Lung Adenocarcinoma Progression via Forming a Positive Feedback Loop With ITGB1/Wnt/β-Catenin/MYC. Frontiers in cell and developmental biology 39 33763420
2014 Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative colitis patients. World journal of gastroenterology 39 25386078
2022 RNA sequencing of single allergen-specific memory B cells after grass pollen immunotherapy: Two unique cell fates and CD29 as a biomarker for treatment effect. Allergy 38 36153670
1998 Increase in memory (CD4+CD29+ and CD4+CD45RO+) T and naive (CD4+CD45RA+) T-cell subpopulations in smokers. Archives of environmental health 38 9886155
2023 USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer. Cancer communications (London, England) 37 37386737
2021 ITGB1 Drives Hepatocellular Carcinoma Progression by Modulating Cell Cycle Process Through PXN/YWHAZ/AKT Pathways. Frontiers in cell and developmental biology 37 34977001
2024 A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 35 38968684
2019 TIMP-1 promotes hypermigration of Toxoplasma-infected primary dendritic cells via CD63-ITGB1-FAK signaling. Journal of cell science 35 30635444
2020 Hsa_circ_CSPP1/MiR-361-5p/ITGB1 Regulates Proliferation and Migration of Cervical Cancer (CC) by Modulating the PI3K-Akt Signaling Pathway. Reproductive sciences (Thousand Oaks, Calif.) 34 32046405
2021 CD29 Enriches for Cytotoxic Human CD4+ T Cells. Journal of immunology (Baltimore, Md. : 1950) 33 34782446
2020 Maspin suppresses cell invasion and migration in gastric cancer through inhibiting EMT and angiogenesis via ITGB1/FAK pathway. Human cell 31 32409959
2018 ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer. Scientific reports 30 29402961
2020 Total Glucosides of Paeony Alleviate Cell Apoptosis and Inflammation by Targeting the Long Noncoding RNA XIST/MicroRNA-124-3p/ITGB1 Axis in Renal Ischemia/Reperfusion Injury. Mediators of inflammation 29 33299380
2011 Highly osteogenic PDL stem cell clones specifically express elevated levels of ICAM1, ITGB1 and TERT. Cytotechnology 29 21866310
2022 CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma model. Oncoimmunology 28 35003897
2022 ITGA5 and ITGB1 contribute to Sorafenib resistance by promoting vasculogenic mimicry formation in hepatocellular carcinoma. Cancer medicine 28 35946175
2016 Long noncoding RNA linc-ITGB1 promotes cell migration and invasion in human breast cancer. Biotechnology and applied biochemistry 28 26601916
2015 The role of CD29-ILK-Akt signaling-mediated epithelial-mesenchymal transition of liver epithelial cells and chemoresistance and radioresistance in hepatocellular carcinoma cells. Medical oncology (Northwood, London, England) 28 25805567
2025 CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance. Molecular cancer 27 39891203
2022 DDR2 Expression in Cancer-Associated Fibroblasts Promotes Ovarian Cancer Tumor Invasion and Metastasis through Periostin-ITGB1. Cancers 27 35884543
2020 Long noncoding RNA NR2F1-AS1 promotes the malignancy of non-small cell lung cancer via sponging microRNA-493-5p and thereby increasing ITGB1 expression. Aging 27 32784268
2019 Trophoblast-derived CXCL12 promotes CD56bright CD82- CD29+ NK cell enrichment in the decidua. American journal of reproductive immunology (New York, N.Y. : 1989) 27 31650642
2019 Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition. Experimental and therapeutic medicine 27 31853313
2017 SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7. Experimental cell research 27 28237246
2024 Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model. Journal of advanced research 26 38417575
2013 Sox10 and Itgb1 interaction in enteric neural crest cell migration. Developmental biology 26 23608456
1995 Increased expression of adhesion molecules (CD54, CD29 and CD44) on fibroblasts infected with cytomegalovirus. Microbiology and immunology 26 7540252
2018 Knockdown of long non-coding RNA linc-ITGB1 inhibits cancer stemness and epithelial-mesenchymal transition by reducing the expression of Snail in non-small cell lung cancer. Thoracic cancer 25 30485693
1993 Suppressive effect of T cell proliferation via the CD29 molecule. The CD29 mAb 1 "K20" decreases diacylglycerol and phosphatidic acid levels in activated T cells. Journal of immunology (Baltimore, Md. : 1950) 25 7686929
2022 Mucin 5AC-Mediated CD44/ITGB1 Clustering Mobilizes Adipose-Derived Mesenchymal Stem Cells to Modulate Pancreatic Cancer Stromal Heterogeneity. Gastroenterology 24 35219699
2021 Molecular Pathogenesis and Regulation of the miR-29-3p-Family: Involvement of ITGA6 and ITGB1 in Intra-Hepatic Cholangiocarcinoma. Cancers 24 34199886
2021 LncRNA LINC00115 facilitates lung cancer progression through miR-607/ITGB1 pathway. Environmental toxicology 24 34643030
2016 Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways. Molecular and cellular biology 24 27795299
2023 Knockdown of lncRNA MALAT1 attenuates renal interstitial fibrosis through miR-124-3p/ITGB1 axis. Scientific reports 23 37872392
2022 Interfering with ITGB1-DT expression delays cancer progression and promotes cell sensitivity of NSCLC to cisplatin by inhibiting the MAPK/ERK pathway. American journal of cancer research 23 35968342
2019 MicroRNA‑3653 inhibits the growth and metastasis of hepatocellular carcinoma by inhibiting ITGB1. Oncology reports 23 30664185
2024 RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling. Journal of experimental & clinical cancer research : CR 22 38326908
1997 CD29 expression on CD4+ gingival lymphocytes supports migration of activated memory T lymphocytes to diseased periodontal tissue. Oral microbiology and immunology 22 9467397
2020 Long noncoding RNA ZFPM2-AS1 regulates ITGB1 by miR-1226-3p to promote cell proliferation and invasion in hepatocellular carcinoma. European review for medical and pharmacological sciences 21 32744687
2013 Expression of stem cell markers: OCT4, KIT, ITGA6, and ITGB1 in the male germinal epithelium. Systems biology in reproductive medicine 21 23758503
1992 Regulation of T cell proliferation by anti-CD49d and anti-CD29 monoclonal antibodies. Journal of leukocyte biology 21 1383369
2011 NOX2-derived reactive oxygen species are crucial for CD29-induced pro-survival signalling in cardiomyocytes. Cardiovascular research 20 22198504
2009 Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147. Immunobiology 20 19576658
2021 miR-497 defect contributes to gastric cancer tumorigenesis and progression via regulating CDC42/ITGB1/FAK/PXN/AKT signaling. Molecular therapy. Nucleic acids 19 34589278
1990 The distribution of CD45R, CD29 and CD45RO (UCHL1) antigens in mature CD4 positive T-cell leukaemias. British journal of haematology 19 2346723
2024 Immunosuppressive CD29+ Treg accumulation in the liver in mice on checkpoint inhibitor therapy. Gut 18 37770128
2022 A CAF-Fueled TIMP-1/CD63/ITGB1/STAT3 Feedback Loop Promotes Migration and Growth of Breast Cancer Cells. Cancers 18 36291767
2019 Long Noncoding RNA UCA1 Accelerates Nasopharyngeal Carcinoma Cell Progression By Modulating miR-124-3p/ITGB1 Axis. OncoTargets and therapy 18 31632090
2021 Clinical Significance of HSPD1/MMP14/ITGB1/miR-6881-5P/Lnc-SPARCL1-1:2 RNA Panel in NAFLD/NASH Diagnosis: Egyptian Pilot Study. Biomedicines 17 34572434
2024 ITGB1 and DDR activation as novel mediators in acquired resistance to osimertinib and MEK inhibitors in EGFR-mutant NSCLC. Scientific reports 16 38177190
2023 ITGB1 alleviates osteoarthritis by inhibiting cartilage inflammation and apoptosis via activating cAMP pathway. Journal of orthopaedic surgery and research 16 37941009
2024 Hypoxic Upregulation of IER2 Increases Paracrine GMFG Signaling of Endoplasmic Reticulum Stress-CAF to Promote Chordoma Progression via Targeting ITGB1. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 15 39207055
2019 Biological Characteristics and Clinical Significance of ITGB1 and RHOC in Patients With Recurrent Colorectal Cancer. Anticancer research 15 31519588
2015 CD4+CD29+T cells are blamed for the persistent inflammatory response in ulcerative colitis. International journal of clinical and experimental pathology 15 26045768
2023 Hypoxia promotes immune escape of pancreatic cancer cells by lncRNA NNT-AS1/METTL3-HuR-mediated ITGB1 m6A modification. Experimental cell research 14 37659467
2022 miR-134-5p inhibits osteoclastogenesis through a novel miR-134-5p/Itgb1/MAPK pathway. The Journal of biological chemistry 14 35691339
2024 FBLN2 is associated with basal cell markers Krt14 and ITGB1 in mouse mammary epithelial cells and has a preferential expression in molecular subtypes of human breast cancer. Breast cancer research and treatment 13 39110274
2023 CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation. BMC cancer 13 36997926
2023 Evaluation of ITGB1 expression as a predictor of the therapeutic effects of immune checkpoint inhibitors in gastric cancer. BMC gastroenterology 13 37667169
2021 Isolation and Characterization of Tissue Resident CD29-Positive Progenitor Cells in Livestock to Generate a Three-Dimensional Meat Bud. Cells 13 34572147
2019 FRK suppresses human glioma growth by inhibiting ITGB1/FAK signaling. Biochemical and biophysical research communications 13 31395336
2019 LncRNA ITGB1 promotes the development of bladder cancer through regulating microRNA-10a expression. European review for medical and pharmacological sciences 13 31486485
2018 Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity. Blood advances 13 30538113
1999 Upregulated expression of VLA proteins and CD29 in peripheral blood lymphocytes of chronic alcoholics without ethanol-related diseases. Alcoholism, clinical and experimental research 13 10069570
2024 Cancer-associated fibroblast-derived extracellular vesicles promote lymph node metastases in oral cavity squamous cell carcinoma by encapsulating ITGB1 and BMI1. BMC cancer 12 38254031
2022 An original amino acid formula favours in vitro corneal epithelial wound healing by promoting Fn1, ITGB1, and PGC-1α expression. Experimental eye research 12 35390334
2022 KLF14 targets ITGB1 to inhibit the progression of cervical cancer via the PI3K/AKT signalling pathway. Discover oncology 12 35570248
2020 SPARCL1 Influences Bovine Skeletal Muscle-Derived Satellite Cell Migration and Differentiation through an ITGB1-Mediated Signaling Pathway. Animals : an open access journal from MDPI 12 32781616
2019 Long noncoding RNA ITGB1 promotes migration and invasion of clear cell renal cell carcinoma by downregulating Mcl-1. European review for medical and pharmacological sciences 12 30915742
2016 Molecular association of CD98, CD29, and CD147 critically mediates monocytic U937 cell adhesion. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 12 27610038
1994 Peripheral blood reduction of memory (CD29+, CD45RO+, and "bright" CD2+ and LFA-1+) T lymphocytes in Papillon-Lefèvre syndrome. Human immunology 12 7532641
2024 Type X collagen knockdown inactivate ITGB1/PI3K/AKT to suppress chronic unpredictable mild stress-stimulated triple-negative breast cancer progression. International journal of biological macromolecules 11 38866293
2018 Long non-coding RNA linc-ITGB1 promotes cell proliferation, migration, and invasion in human hepatoma carcinoma by up-regulating ROCK1. Bioscience reports 11 30279202
2023 Psoralidin inhibits osteosarcoma growth and metastasis by downregulating ITGB1 expression via the FAK and PI3K/Akt signaling pathways. Chinese medicine 10 37004120
2021 Platelets differentially modulate CD4+ Treg activation via GPIIa/IIIb-, fibrinogen-, and PAR4-dependent pathways. Immunologic research 10 34932195
2020 MicroRNA-374b mediates the initiation of non-small cell lung cancer by regulating ITGB1 and p53 expressions. Thoracic cancer 10 32364676
2019 CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation. European journal of immunology 10 31318439

Missed literature

Know a paper Affinage missed for ITGB1? Flag it for the maintainers and the community.

No submissions yet.