Affinage

ATP6V0A1

V-type proton ATPase 116 kDa subunit a 1 · UniProt Q93050

Round 2 corrected
Length
837 aa
Mass
96.4 kDa
Annotated
2026-04-28
130 papers in source corpus 13 papers cited in narrative 13 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ATP6V0A1 encodes the a1 isoform of the V0 membrane domain of vacuolar H+-ATPases, serving as the central proton-translocation subunit that is essential for V-ATPase assembly, organelle-specific targeting, and compartment acidification in neurons and other cell types (PMID:1385813, PMID:9442887, PMID:32001091). It maintains endolysosomal pH required for lysosomal hydrolysis, autophagy flux, mTORC1 signaling, and synaptic vesicle neurotransmitter loading; its activity is directly stimulated by PI(3,5)P₂ binding to a basic sequence in its cytosolic N-terminal domain (PMID:31023825, PMID:33833240). De novo and biallelic missense variants in ATP6V0A1 cause developmental and epileptic encephalopathy and progressive myoclonus epilepsy with ataxia through impaired lysosomal acidification and neuronal dysfunction (PMID:33833240, PMID:34909687). In colorectal cancer, ATP6V0A1 facilitates RABGEF1-dependent endosome maturation for cholesterol absorption, driving LXR/TGF-β1-mediated suppression of memory CD8⁺ T cells (PMID:38971819).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 1992 High

    Identification of Vph1p (the yeast ortholog of ATP6V0A1) as an essential V0 subunit resolved how the V-ATPase membrane domain is assembled and how it couples to the peripheral V1 catalytic domain for proton pumping.

    Evidence Genetic deletion/complementation and vacuolar ATPase/proton-pumping assays in S. cerevisiae

    PMID:1385813

    Open questions at the time
    • Mammalian isoform-specific functions not yet addressed
    • Structural basis of V1–V0 coupling through the a subunit unknown
    • Regulation of V-ATPase assembly/disassembly not characterized
  2. 2002 High

    Recognition that different a-subunit isoforms (a1–a4) confer organelle-specific targeting of V-ATPase complexes established the principle that ATP6V0A1 directs the pump to neuronal and endolysosomal compartments, explaining compartment-specific acidification.

    Evidence Synthesis of biochemical, genetic, and immunolocalization studies across multiple systems

    PMID:11836511 PMID:9442887

    Open questions at the time
    • Targeting signals within the a1 isoform not mapped
    • Relative contribution of a1 versus other isoforms in overlapping compartments unresolved
  3. 2011 High

    Quantitative pH measurements showed that Vph1-containing V-ATPases are the primary determinants of vacuolar pH homeostasis, with their loss causing more severe alkalinization than complete V-ATPase deletion and secondary impairment of cytosolic pH regulation.

    Evidence Ratiometric vacuolar and cytosolic pH reporters (pHluorin) in yeast vph1Δ and vma mutants

    PMID:21669878

    Open questions at the time
    • Mechanism linking vacuolar alkalinization to Pma1p inhibition not identified
    • Relevance to mammalian ATP6V0A1-containing V-ATPases not tested
  4. 2011 High

    A human 3′-UTR polymorphism in ATP6V0A1 that modulates miR-637-mediated repression demonstrated that graded reduction in a1 expression is sufficient to impair secretory granule acidification and chromogranin A processing, linking V-ATPase dosage to neuroendocrine exocytosis.

    Evidence Luciferase reporters, intragranular pH monitoring via CHGA/EGFP, MALDI-MS of CHGA processing in chromaffin cells

    PMID:21558123

    Open questions at the time
    • In vivo cardiovascular or endocrine phenotype of the variant not established
    • Whether other miRNAs regulate ATP6V0A1 in neurons unknown
  5. 2019 High

    Identification of PI(3,5)P₂ as a direct activator of Vph1-containing V-ATPases, binding a specific basic motif (231KTREYKHK) in the cytosolic N-terminal domain, revealed the first lipid-based regulatory mechanism for isoform-selective V-ATPase activation.

    Evidence Exogenous short-chain PI(3,5)P₂ addition to isolated yeast vacuolar vesicles, site-directed mutagenesis, genetic epistasis with hog1Δ

    PMID:31023825

    Open questions at the time
    • Conservation of PI(3,5)P₂ activation for mammalian ATP6V0A1 not demonstrated
    • Structural basis of PI(3,5)P₂ binding at atomic resolution not available
    • Whether other phosphoinositides regulate a1 activity unknown
  6. 2020 High

    Cryo-EM structures confirmed that the a subunit forms the proton half-channels within V0 and mediates regulated V1–V0 disassembly, providing the structural framework for understanding how ATP6V0A1 mutations impair function.

    Evidence Cryo-EM structural determination with biochemical activity measurements synthesized across laboratories

    PMID:32001091

    Open questions at the time
    • Isoform-resolved cryo-EM structure of mammalian a1-containing V-ATPase not yet obtained
    • Structural mechanism of PI(3,5)P₂-mediated activation not resolved
  7. 2021 High

    Human genetic and animal model studies established that ATP6V0A1 mutations cause developmental and epileptic encephalopathy and progressive myoclonus epilepsy by impairing lysosomal acidification, autophagy, mTORC1 signaling, and synaptic vesicle loading, defining ATP6V0A1 as a Mendelian disease gene for neuronal disorders.

    Evidence Patient variant identification, knock-in mouse models (R741Q, A512P), C. elegans R740Q modeling, lysosomal pH assays, neuropathology, synaptic connectivity and neurotransmitter quantification

    PMID:33833240 PMID:34909687

    Open questions at the time
    • Genotype–phenotype correlation for individual variants incomplete
    • Whether mTORC1 signaling deficit is primary or secondary to lysosomal dysfunction unresolved
    • Therapeutic rescue strategies not demonstrated
  8. 2024 High

    Discovery that ATP6V0A1 drives cholesterol-mediated immunosuppression in colorectal cancer through RABGEF1-dependent endosome maturation, 24-OHC/LXR signaling, and TGF-β1 release expanded the gene's role beyond housekeeping acidification to tumor immune evasion.

    Evidence CRC cell lines, cholesterol uptake and endosome maturation assays, 24-OHC quantification, LXR reporters, CD8⁺ T cell SMAD3 signaling, in vivo tumor models, daclatasvir inhibition

    PMID:38971819

    Open questions at the time
    • Whether ATP6V0A1-dependent cholesterol absorption operates in non-CRC cancers unknown
    • Selectivity and mechanism of daclatasvir as an ATP6V0A1 inhibitor not structurally resolved
    • Contribution of other a-subunit isoforms to this pathway not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • The isoform-resolved structure of mammalian ATP6V0A1-containing V-ATPase, the conservation of PI(3,5)P₂ activation in human cells, and the precise mechanism by which individual disease-causing missense mutations disrupt proton translocation remain unresolved.
  • No mammalian isoform-specific cryo-EM structure
  • PI(3,5)P₂ activation not validated for human ATP6V0A1
  • Genotype-to-structural-defect mapping for patient variants lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 4 GO:0005198 structural molecule activity 3 GO:0008289 lipid binding 1
Localization
GO:0005764 lysosome 3 GO:0005773 vacuole 3 GO:0031410 cytoplasmic vesicle 2 GO:0005768 endosome 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-382551 Transport of small molecules 5 R-HSA-1643685 Disease 3 R-HSA-112316 Neuronal System 2 R-HSA-162582 Signal Transduction 2 R-HSA-1852241 Organelle biogenesis and maintenance 2 R-HSA-5653656 Vesicle-mediated transport 2 R-HSA-9612973 Autophagy 2
Partners
ATP6V1AATP6V1B2CRYBA1RABGEF1
Complex memberships
V-ATPase (V0 domain)

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 The yeast VPH1 gene (ortholog of human ATP6V0A1) encodes a 95-kDa integral membrane polypeptide of the V0 domain that is essential for vacuolar H+-ATPase assembly and vacuolar acidification. Loss of VPH1 abolishes bafilomycin-sensitive ATPase activity and ATP-dependent proton pumping in vacuoles, and causes the peripheral nucleotide-binding subunits (60 and 69 kDa) of the V-ATPase to dissociate from vacuolar membranes, demonstrating that Vph1p is required for V1 domain attachment to the membrane V0 domain. Genetic deletion/complementation, vacuolar ATPase activity assays, proton pumping assays, cell fractionation, immunodetection, antibody library screening The Journal of biological chemistry High 1385813
1997 The V-ATPase is a multisubunit complex composed of a peripheral V1 domain (responsible for ATP hydrolysis, subunits A–H) and an integral V0 domain (responsible for proton translocation, subunits a–d). The 'a' subunit (the ortholog of ATP6V0A1) resides in the V0 domain and is required for proton translocation. Assembly of V1 onto V0 is a regulated process, and the 'a' subunit isoforms determine organelle targeting. Biochemical reconstitution, genetic analysis, subunit mutagenesis studies reviewed Annual review of cell and developmental biology High 9442887
2001 In Cryptococcus neoformans, disruption of VPH1 (ortholog of ATP6V0A1) results in defects in multiple virulence factors (capsule production, laccase activity, urease expression) and a growth defect at 37°C, phenocopied by the V-ATPase inhibitor bafilomycin A1. These defects are rescued by complementation with wild-type VPH1, establishing that Vph1p-dependent vesicular acidification is required for proper protein secretion, metal cofactor insertion (for laccase), and glycosylation processes in vivo. Insertional mutagenesis, plasmid rescue, complementation, bafilomycin A1 inhibition, virulence assays in mouse model Molecular microbiology High 11737651
2002 V-ATPases are the primary drivers of intracellular compartment acidification in eukaryotes. The 'a' subunit isoforms of the V0 domain (including the a1 isoform encoded by ATP6V0A1) determine the specific organelle targeting of the V-ATPase complex, with different isoforms directing the pump to distinct intracellular compartments (e.g., lysosomes, Golgi, synaptic vesicles). This isoform-based targeting underlies compartment-specific acidification. Biochemical and genetic analysis reviewed; isoform-specific localization studies Nature reviews. Molecular cell biology High 11836511
2007 The a1 isoform (ATP6V0A1) of the V-ATPase V0 domain is expressed in the mouse kidney and localizes to both the apical and basolateral membranes of intercalated cells of the collecting system, as well as to the proximal tubule. In intercalated cells, a1 co-localizes with both AE1 (type A intercalated cells) and pendrin (type B intercalated cells), unlike the a2 isoform which is absent from pendrin-expressing cells. This differential localization suggests that V-ATPases containing different 'a' subunit isoforms serve distinct physiological roles along the nephron. Real-time PCR for expression quantification, immunolocalization with isoform-specific antibodies in mouse kidney sections Cellular physiology and biochemistry Medium 17595521
2011 In yeast, loss of VPH1 (the vacuole-targeted a-subunit isoform orthologous to human ATP6V0A1) results in more severe vacuolar alkalinization than loss of all V-ATPase activity (vma mutants), and causes reduced activity of the plasma membrane proton pump Pma1p despite Pma1p remaining correctly localized at the plasma membrane. This demonstrates that Vph1-containing V-ATPases are the primary determinants of vacuolar pH homeostasis, and that loss of vacuolar acidification secondarily impairs cytosolic pH regulation and Pma1 activity through a mechanism distinct from Pma1 mislocalization. Ratiometric vacuolar pH measurements (fluorescent reporters), cytosolic pH measurements with pHluorin, cell fractionation, plasma membrane Pma1p localization by imaging The Journal of biological chemistry High 21669878
2011 A common 3'-UTR polymorphism (T+3246C, rs938671) in ATP6V0A1 creates a binding motif for microRNA hsa-miR-637. The C (variant) allele decreases ATP6V0A1 expression via differential miRNA-mediated repression, as shown by luciferase reporter assays and in vitro transcription/translation. Reduced ATP6V0A1 expression impairs chromaffin granule acidification (monitored by CHGA/EGFP fluorescence during bafilomycin A1 treatment), thereby altering chromogranin A (CHGA) processing to catestatin and reducing exocytotic secretion from the regulated pathway. Luciferase reporter assays with ATP6V0A1 3'-UTR, in vitro transcription/translation, intragranular pH monitoring by CHGA/EGFP chimera fluorescence, bafilomycin A1 treatment, immunoblot/MALDI-MS of CHGA processing fragments, miRNA precursor/antagomir cotransfection Circulation. Cardiovascular genetics High 21558123
2014 βA3/A1-crystallin (encoded by Cryba1) directly interacts with V-ATPase, the proton pump responsible for acidification of the endolysosomal system, in retinal astrocytes and retinal pigment epithelial (RPE) cells. Loss of βA3/A1-crystallin impairs lysosomal acidification, leading to defective phagocytosis and autophagy and accumulation of undigested cargo in autophagolysosomes, resembling pathological changes in age-related macular degeneration. This establishes a regulatory interaction between βA3/A1-crystallin and V-ATPase (which contains the ATP6V0A1 a1-subunit as its predominant neuronal isoform) in maintaining endolysosomal pH. Spontaneous rat mutant and genetically engineered mouse models, lysosomal pH measurements, phagocytosis/autophagy assays, co-immunoprecipitation/interaction studies with V-ATPase Progress in retinal and eye research Medium 25461968
2019 The signaling lipid PI(3,5)P2 directly activates V-ATPase activity and proton pumping in yeast vacuolar vesicles containing the Vph1 isoform (ortholog of human ATP6V0A1), but not Stv1-containing vesicles. Addition of exogenous short-chain PI(3,5)P2 to isolated Vph1-containing vacuolar vesicles increases V-ATPase activity. Structural modeling and mutagenesis identified a membrane-oriented basic sequence (231KTREYKHK) in the cytosolic N-terminal domain of Vph1 as the PI(3,5)P2 interaction site; substitutions in this region abolish PI(3,5)P2-dependent activation without affecting basal V-ATPase activity. Loss of PI(3,5)P2 activation leads to enlarged vacuoles and a synthetic growth defect with deletion of the osmotic stress kinase Hog1. Biochemical characterization of isolated yeast vacuolar vesicles, exogenous short-chain PI(3,5)P2 addition, V-ATPase activity and proton pumping assays, computational domain modeling, site-directed mutagenesis of basic residues, genetic epistasis with hog1Δ The Journal of biological chemistry High 31023825
2020 Cryo-EM and biochemical studies of V-ATPases reveal that the 'a' subunit (of which ATP6V0A1 is the neuronal isoform) forms the central component of the V0 membrane domain and contains the proton translocation half-channels. Regulated and reversible disassembly of V1 from V0 modulates enzymatic activity, and different 'a' subunit isoforms (a1–a4) are differentially localized to distinct organelles, though the biochemical properties of individual mammalian isoforms remain to be fully characterized. Cryo-EM structural analysis, biochemical activity measurements, reviewed from multiple studies Trends in biochemical sciences High 32001091
2021 De novo missense variants in ATP6V0A1 (R741Q and A512P/N534D in biallelic form) cause developmental and epileptic encephalopathy in humans. Cell lines expressing these missense mutants show significantly impaired lysosomal acidification. Homozygous Atp6v0a1R741Q mice show embryonic lethality, while Atp6v0a1A512P/A512P mice show early postnatal mortality with brain pathology including: lysosomal dysfunction with cell death, accumulation of autophagosomes and lysosomes, reduced mTORC1 signaling, reduced synaptic connectivity, and lowered neurotransmitter contents of synaptic vesicles. This establishes ATP6V0A1 as essential for neuronal integrity, synaptic vesicle neurotransmitter loading, autophagy flux, and mTORC1 signaling in the brain. Patient variant identification, cell line expression of mutants with lysosomal pH assays, homozygous knock-in mouse models, embryonic lethality/postnatal survival analysis, neuropathology, autophagosome/lysosome quantification, mTORC1 signaling assays, synaptic connectivity and neurotransmitter content measurements Nature communications High 33833240
2021 The R740Q variant in ATP6V0A1 (equivalent to R741Q in the mouse study) directly impairs endolysosomal acidification, leading to failure of lysosomal hydrolysis, autophagic dysfunction, and severe developmental defects in C. elegans. Biallelic ATP6V0A1 variants cause progressive myoclonus epilepsy with ataxia, while de novo missense variants cause severe developmental and epileptic encephalopathy, expanding the neurological phenotype spectrum. The R740Q mutation accounts for ~50% of identified mutations. Patient cohort genetic analysis, C. elegans modeling of R740Q with endolysosomal acidification assays, lysosomal hydrolysis assays, autophagy dysfunction assessment Brain communications High 34909687
2024 Tumor cell-intrinsic ATP6V0A1 drives exogenous cholesterol-induced immunosuppression in colorectal cancer (CRC). ATP6V0A1 facilitates cholesterol absorption in CRC cells through RABGEF1-dependent endosome maturation, causing cholesterol accumulation in the endoplasmic reticulum and elevated production of 24-hydroxycholesterol (24-OHC). ATP6V0A1-induced 24-OHC activates liver X receptor (LXR) signaling to upregulate TGF-β1. Released TGF-β1 activates the SMAD3 pathway in memory CD8+ T cells, suppressing their anti-tumor activity. The anti-HCV drug daclatasvir was identified as an ATP6V0A1 inhibitor that enhances memory CD8+ T cell activity and suppresses CRC tumor growth. Tumor cell line experiments, cholesterol uptake assays, endosome maturation assays, 24-OHC quantification, LXR signaling reporters, TGF-β1 ELISA, SMAD3 pathway assays in CD8+ T cells, in vivo tumor mouse models, drug (daclatasvir) inhibition assays Nature communications High 38971819

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2008 Identification of host proteins required for HIV infection through a functional genomic screen. Science (New York, N.Y.) 1165 18187620
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2018 Normal aging induces A1-like astrocyte reactivity. Proceedings of the National Academy of Sciences of the United States of America 997 29437957
2002 The vacuolar (H+)-ATPases--nature's most versatile proton pumps. Nature reviews. Molecular cell biology 961 11836511
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 Large-scale proteomics and phosphoproteomics of urinary exosomes. Journal of the American Society of Nephrology : JASN 607 19056867
1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene 492 8125298
1997 Structure, function and regulation of the vacuolar (H+)-ATPase. Annual review of cell and developmental biology 488 9442887
1994 RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. The EMBO journal 460 7510636
1995 A nuclear localization domain in the hnRNP A1 protein. The Journal of cell biology 457 7730395
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2008 Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy 428 18758232
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
1999 Vacuolar and plasma membrane proton-adenosinetriphosphatases. Physiological reviews 348 10221984
2007 Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation. Cell 307 17662945
2016 Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. Cell reports 306 27342126
1999 Structure and properties of the vacuolar (H+)-ATPases. The Journal of biological chemistry 252 10224039
1998 Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nature genetics 251 9620782
2012 Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. The Journal of clinical investigation 247 23241962
1991 Structure and function of A1 adenosine receptors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 230 1916091
1992 The VPH1 gene encodes a 95-kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H(+)-ATPase. The Journal of biological chemistry 220 1385813
2009 Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Molecular psychiatry 213 20038947
2011 Toward an understanding of the protein interaction network of the human liver. Molecular systems biology 207 21988832
1999 Animal plasma membrane energization by proton-motive V-ATPases. BioEssays : news and reviews in molecular, cellular and developmental biology 206 10440860
1997 The vacuolar H+-ATPase: a universal proton pump of eukaryotes. The Biochemical journal 199 9210392
1991 The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor. The EMBO journal 195 1646713
2016 Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. Cancer cell 184 27622334
2014 Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. Molecular cell 173 25544563
1986 Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor. Biochimie 169 2874839
2020 Structure and Roles of V-type ATPases. Trends in biochemical sciences 168 32001091
1985 Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn-Schmiedeberg's archives of pharmacology 168 2997628
2016 Serum amyloid A1: Structure, function and gene polymorphism. Gene 161 26945629
2018 Annexin A1: Uncovering the Many Talents of an Old Protein. International journal of molecular sciences 160 29614751
1998 Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene. The Journal of experimental medicine 159 9841913
2005 The Arabidopsis STV1 protein, responsible for translation reinitiation, is required for auxin-mediated gynoecium patterning. The Plant cell 152 16227452
2006 hnRNP A1 associates with telomere ends and stimulates telomerase activity. RNA (New York, N.Y.) 127 16603717
1998 Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells. Blood 127 9763560
1999 Up-regulation of ephrin-A1 during melanoma progression. International journal of cancer 122 10502726
2016 Annexin A1 localization and its relevance to cancer. Clinical science (London, England : 1979) 116 26769657
2011 Phospholipases A₁. International journal of molecular sciences 116 21340002
2012 AMP is an adenosine A1 receptor agonist. The Journal of biological chemistry 110 22215671
2009 Cooperative-binding and splicing-repressive properties of hnRNP A1. Molecular and cellular biology 91 19667073
2004 MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription. Nucleic acids research 90 15316101
2019 Annexin-A1 - A Blessing or a Curse in Cancer? Trends in molecular medicine 88 30871809
1993 Disparate effects of adenosine A1- and A2-receptor agonists on intrarenal blood flow. The American journal of physiology 83 8285213
2003 Ultraviolet A1 phototherapy. The British journal of dermatology 81 12752118
2001 Multiple virulence factors of Cryptococcus neoformans are dependent on VPH1. Molecular microbiology 81 11737651
2011 Contrasting effects of A1 and A2b adenosine receptors on adipogenesis. International journal of obesity (2005) 79 21730968
1997 Desensitisation of the adenosine A1 receptor by the A2A receptor in the rat striatum. Journal of neurochemistry 79 9202325
2020 High-Density Lipoproteins and Apolipoprotein A1. Sub-cellular biochemistry 75 32189309
2008 Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage. European journal of pharmacology 75 18727925
2011 Ephs and ephrins in cancer: ephrin-A1 signalling. Seminars in cell & developmental biology 72 22040911
2009 A1 adenosine receptor: role in diabetes and obesity. Handbook of experimental pharmacology 72 19639285
1996 Binding thermodynamics at A1 and A2A adenosine receptors. Life sciences 72 8890916
1988 A1 and A2 adenosine receptor regulation of erythropoietin production. Life sciences 67 3398696
2013 The complex understanding of Annexin A1 phosphorylation. Cellular signalling 64 24103589
2013 ADAM12-cleaved ephrin-A1 contributes to lung metastasis. Oncogene 62 23686306
2003 Adenosine A1 receptor antagonists and the kidney. Current opinion in nephrology and hypertension 62 12920396
2018 Facilitation of MrgprD by TRP-A1 promotes neuropathic pain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 61 30148678
2016 Annexin A1: shifting the balance towards resolution and repair. Biological chemistry 59 27232634
2021 ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H+-ATPases is essential for brain development in humans and mice. Nature communications 54 33833240
2018 Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury. International journal of molecular sciences 54 29659553
2004 Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. The Journal of biological chemistry 54 15159402
2003 Attenuation of glucocorticoid functions in an Anx-A1-/- cell line. The Biochemical journal 54 12553880
1986 Interaction of carbamazepine and other drugs with adenosine (A1 and A2) receptors. Psychopharmacology 54 3097720
2019 Serum amyloid A1 mediates myotube atrophy via Toll-like receptors. Journal of cachexia, sarcopenia and muscle 53 31441598
2018 Annexin A1 and Autoimmunity: From Basic Science to Clinical Applications. International journal of molecular sciences 52 29751523
2018 Total Enzyme Syntheses of Napyradiomycins A1 and B1. Journal of the American Chemical Society 52 30525563
2011 Consequences of loss of Vph1 protein-containing vacuolar ATPases (V-ATPases) for overall cellular pH homeostasis. The Journal of biological chemistry 51 21669878
2008 Anti-inflammatory preconditioning by agonists of adenosine A1 receptor. PloS one 50 18461129
2010 Role of Annexin A1 in mouse myoblast cell differentiation. Journal of cellular physiology 49 20578244
2008 Expression of BORIS in melanoma: lack of association with MAGE-A1 activation. International journal of cancer 47 17957795
2022 Annexin-A1: The culprit or the solution? Immunology 46 35146757
2011 Identification of apolipoprotein A1 in the human embryonic secretome. Fertility and sterility 45 21676393
1972 Allergic encephalomyelitis in monkeys induced by a peptide from the A1 protein. Proceedings of the National Academy of Sciences of the United States of America 45 4111048
2013 Regulation of lung fibroblast activation by annexin A1. Journal of cellular physiology 44 22777765
2011 EphA2 receptor activation by monomeric Ephrin-A1 on supported membranes. Biophysical journal 44 22261062
2019 Interaction of the late endo-lysosomal lipid PI(3,5)P2 with the Vph1 isoform of yeast V-ATPase increases its activity and cellular stress tolerance. The Journal of biological chemistry 42 31023825
1987 Glomeruli and microvessels of the rabbit kidney contain both A1- and A2-adenosine receptors. Naunyn-Schmiedeberg's archives of pharmacology 42 3600819
2019 Advancements of Annexin A1 in inflammation and tumorigenesis. OncoTargets and therapy 41 31118675
2012 Attenuation of plasma annexin A1 in human obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 39 23038751
2019 Structural Basis for DNA Gyrase Interaction with Coumermycin A1. Journal of medicinal chemistry 38 30920824
2014 βA3/A1-crystallin: more than a lens protein. Progress in retinal and eye research 38 25461968
2010 Pharmacochaperoning of the A1 adenosine receptor is contingent on the endoplasmic reticulum. Molecular pharmacology 38 20219842
1994 Abnormal A1 adenosine receptor function in genetic obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 38 8299893
2019 Contribution of annexin A1 to anticancer immunosurveillance. Oncoimmunology 37 32923172
2007 Allosteric enhancers for A1 adenosine receptor. Mini reviews in medicinal chemistry 37 17584155
1998 The structure and function of A1 and A2B adenosine receptors. Life sciences 37 9585129
1984 Hydroxylation of prostaglandin A1 by the microsomes of rabbit intestinal mucosa. Journal of biochemistry 37 6469945
2013 Vernalization treatment induces site-specific DNA hypermethylation at the VERNALIZATION-A1 (VRN-A1) locus in hexaploid winter wheat. BMC plant biology 36 24330651
2020 LANA and hnRNP A1 Regulate the Translation of LANA mRNA through G-Quadruplexes. Journal of virology 35 31723020
2013 TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres. Frontiers in oncology 35 23616949
2019 Scavenger receptor A1 attenuates aortic dissection via promoting efferocytosis in macrophages. Biochemical pharmacology 34 31381873
2013 Polymorphism of TaSAP1-A1 and its association with agronomic traits in wheat. Planta 34 23462884
2013 Increased adiposity in annexin A1-deficient mice. PloS one 34 24312665
2012 HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence. Nucleic acids research 34 22740652
2006 Glucocorticoid upregulation of the annexin-A1 receptor in leukocytes. Biochemical and biophysical research communications 34 16973129
2001 A1 adenosine receptors and their ligands: overview and recent developments. Farmaco (Societa chimica italiana : 1989) 34 11347971
2014 Annexin A1 in malignant tumors: current opinions and controversies. The International journal of biological markers 33 24242295
2024 ATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8+ T cells. Nature communications 32 38971819
2019 MicroRNA-99a-5p alleviates atherosclerosis via regulating Homeobox A1. Life sciences 31 31325426
2014 IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection. Biochemical and biophysical research communications 30 24845382
2003 Medicinal chemistry of adenosine A1 receptor ligands. Current topics in medicinal chemistry 30 12570755
2017 STV1, a ribosomal protein, binds primary microRNA transcripts to promote their interaction with the processing complex in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America 29 28115696
2018 Idiosyncrasies of hnRNP A1-RNA recognition: Can binding mode influence function. Seminars in cell & developmental biology 27 29625167
2009 Adenosine A1 receptor blockage mediates theophylline-associated seizures. Epilepsia 27 19845735
2004 Vacuolar H+-translocating inorganic pyrophosphatase (Vpp1) marks partial aleurone cell fate in cereal endosperm development. Plant molecular biology 27 15604747
2024 Loss of Endothelial Annexin A1 Aggravates Inflammation-Induched Vascular Aging. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 26 38358087
2017 Serum amyloid A1 is upregulated in human glioblastoma. Journal of neuro-oncology 26 28283801
2016 Entry of Botulinum Neurotoxin Subtypes A1 and A2 into Neurons. Infection and immunity 26 27795365
1994 Interactions between adenosine A1- and histamine H1-receptors. The International journal of biochemistry 26 8088416
2020 Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNP A1) and hnRNP A2 Inhibit Splicing to Human Papillomavirus 16 Splice Site SA409 through a UAG-Containing Sequence in the E7 Coding Region. Journal of virology 25 32759322
2018 Complete Genome of a Novel Lytic Vibrio parahaemolyticus Phage VPp1 and Characterization of Its Endolysin for Antibacterial Activities. Journal of food protection 25 29927621
2016 Carbon Monoxide Releasing Molecule-A1 (CORM-A1) Improves Neurogenesis: Increase of Neuronal Differentiation Yield by Preventing Cell Death. PloS one 25 27144388
2011 A common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk. Circulation. Cardiovascular genetics 25 21558123
2010 Role of transient receptor potential A1 in gastric nociception. Digestion 25 20588026
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2010 Ubiquitination and SUMOylation of annexin A1 and helicase activity. Biochimica et biophysica acta 24 20359522
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