Affinage

PALLD

Palladin · UniProt Q8WX93

Length
1383 aa
Mass
150.6 kDa
Annotated
2026-06-10
59 papers in source corpus 13 papers cited in narrative 13 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Palladin (PALLD) is an actin-associated scaffold phosphoprotein that organizes the actin cytoskeleton and converts it into specialized cellular machinery across migration, phagocytosis, and tissue-specific differentiation programs (PMID:17194196, PMID:27487483, PMID:28739877). Its immunoglobulin domains carry out the core biochemistry: Ig3 (and Ig34) directly crosslinks, bundles, and polymerizes actin filaments, an activity gated by binding to the membrane lipid PI(4,5)P2, which docks via salt bridges to residues K38 and K51 on Ig3 and inhibits filament assembly (PMID:27487483). The P239S substitution in a conserved region acts as a gain-of-function lesion that drives aberrant actin bundling and increased cell migration (PMID:17194196). Beyond filament organization, palladin functions as an adaptor coupling actin dynamics to signaling: during phagocytosis it promotes receptor clustering and c-Src activation while recruiting the phosphatase OCRL to nascent phagosomes to drive PI(4,5)P2 hydrolysis and actin depolymerization for phagosome closure (PMID:28739877), and in megakaryocytes its Ig3 domain binds STAT3 directly, promoting STAT3 Y705 phosphorylation and nuclear translocation to support proplatelet formation and platelet production (PMID:38813732). Palladin is required for tissue integrity and microenvironment formation in vivo: cardiomyocyte-specific ablation causes dilated cardiomyopathy and intercalated disc abnormalities, where palladin's N-terminus binds CARP/Ankrd1 and FHOD1 (PMID:36927816), and germline knockout impairs fetal liver erythropoiesis by abolishing the ability of macrophages to bind erythroblasts and form erythroblastic islands (PMID:17431131). Palladin also displays isoform-specific nuclear-cytoplasmic shuttling in Sertoli cells that is controlled by FSH-cAMP signaling and F-actin state (PMID:23559268, PMID:24989903), and it promotes cancer cell invasiveness and Wnt/β-catenin-driven stem-like properties, with its expression controlled post-transcriptionally by the RNA-binding protein STAU2 and by miR-96/miR-182 (PMID:36047666, PMID:40539383, PMID:36961307).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2006 Medium

    Established that a single conserved-region missense change in palladin is sufficient to reorganize actin and enhance motility, defining palladin as an active determinant of cytoskeletal architecture rather than a passive marker.

    Evidence Transfection of wild-type vs P239S mutant constructs in HeLa cells, scoring actin bundles and migration

    PMID:17194196

    Open questions at the time
    • Does not establish the biochemical mechanism by which P239S alters actin binding
    • Phenotype shown only in HeLa overexpression, not endogenous tissue
  2. 2007 High

    Showed palladin is required non-cell-autonomously for the erythropoietic microenvironment, localizing its essential role to macrophage adhesion in erythroblastic island formation.

    Evidence Palld-/- knockout mice with colony-forming, island reconstitution, and bone marrow transplantation assays

    PMID:17431131

    Open questions at the time
    • Molecular partners mediating macrophage-erythroblast binding not identified
    • Does not define which palladin isoform drives the macrophage function
  3. 2013 Medium

    Revealed isoform-specific proteolytic processing and compartmentalized localization of palladin in Sertoli cells, implicating a nuclear function distinct from cytoskeletal scaffolding.

    Evidence Immunofluorescence, fractionation, and isoform Western blotting of testis tissue with NES analysis

    PMID:23559268

    Open questions at the time
    • Identity/function of the nuclear C-terminal fragment not determined
    • Cleavage protease unknown
  4. 2014 Medium

    Connected palladin's nuclear-cytoplasmic shuttling to a defined upstream hormonal pathway, showing FSH-cAMP signaling and actin state govern its localization.

    Evidence Primary Sertoli cell culture, pharmacological F-actin depolymerization, and FSH/LH/androgen receptor-mutant mouse testes imaging

    PMID:24989903

    Open questions at the time
    • Nuclear target genes or activity of palladin not defined
    • Mechanism linking F-actin state to import/export not resolved
  5. 2016 High

    Provided the structural-biochemical basis for palladin actin organization and its lipid regulation, mapping PI(4,5)P2 binding to specific Ig3 residues that gate bundling activity.

    Evidence In vitro actin polymerization/bundling assays, NMR titration, docking, and K38 charge-neutralization mutagenesis

    PMID:27487483

    Open questions at the time
    • Does not show PI(4,5)P2 regulation of palladin in a cellular context
    • Relative contributions of Ig3 vs Ig34 in cells not resolved
  6. 2017 High

    Placed palladin in the phagocytic pathway as a coordinator linking actin polymerization, c-Src activation, and OCRL-mediated PI(4,5)P2 hydrolysis for phagosome closure.

    Evidence PALLD knockdown/overexpression in myeloid leukemia cells with phagocytosis assays and imaging of receptor clustering, c-Src, OCRL, and PI(4,5)P2

    PMID:28739877

    Open questions at the time
    • Direct vs indirect nature of the palladin-OCRL recruitment not defined
    • Whether the PI(4,5)P2-gated bundling activity (#2) operates here is untested
  7. 2020 Low

    Characterized isoform-specific promoter architecture of palladin, predicting muscle and developmental transcription factor inputs.

    Evidence Promoter prediction, transcription start site mapping, luciferase reporters, and transcriptome profiling in mouse

    PMID:32620172

    Open questions at the time
    • Computational prediction without direct mutagenesis of promoter elements
    • Functional requirement of the predicted TF sites not tested
  8. 2021 Medium

    Identified a germline palladin mutation segregating in familial pancreatic cancer with predominant stromal (CAF) expression, implicating a microenvironmental predisposition mechanism.

    Evidence Whole exome sequencing, germline confirmation, compartment-specific expression analysis, and CAF IHC in a family

    PMID:33764904

    Open questions at the time
    • Functional consequence of D52N not tested in vitro
    • Causality vs association in tumorigenesis not established
  9. 2022 Medium

    Placed palladin upstream of Wnt/β-catenin in driving cancer stem cell-like properties, extending its role from motility to stemness.

    Evidence Overexpression/knockdown in NSCLC lines with sphere assays, β-catenin Western blot, xenografts, and Wnt inhibitor rescue

    PMID:36047666

    Open questions at the time
    • Molecular link between palladin and β-catenin accumulation not defined
    • Single lung cancer context
  10. 2023 High

    Established palladin as essential for adult cardiac structure and contractility and identified CARP/Ankrd1 and FHOD1 as N-terminal interaction partners at the intercalated disc.

    Evidence Inducible cardiomyocyte-specific knockout mice with echocardiography, contractility assays, MYPN double knockout, and yeast two-hybrid screening

    PMID:36927816

    Open questions at the time
    • Yeast two-hybrid interactions not validated biochemically in cardiomyocytes
    • How loss of these interactions causes disc disruption not mechanistically resolved
  11. 2023 Medium

    Identified palladin as a functional effector downstream of miR-96/miR-182 controlling glioblastoma cell motility.

    Evidence miRNA overexpression with RT-PCR/Western blot and palladin rescue of motility in U251 MG cells

    PMID:36961307

    Open questions at the time
    • Direct vs indirect miRNA targeting of PALLD transcript not fully resolved
    • Single GBM cell line
  12. 2024 High

    Revealed a non-cytoskeletal signaling role in which palladin Ig3 binds STAT3 to promote its activation and nuclear entry during platelet biogenesis, and validated this with a structure-based rescue peptide.

    Evidence Megakaryocyte/platelet-specific Palld knockout mice, Co-IP domain mapping, phospho-STAT3 Western blot, nuclear translocation imaging, and in vivo C-P3 peptide rescue

    PMID:38813732

    Open questions at the time
    • Mechanism by which palladin binding enhances STAT3 Y705 phosphorylation not defined
    • Generalizability of palladin-STAT3 axis beyond megakaryocytes untested
  13. 2025 Medium

    Connected post-transcriptional control of PALLD by STAU2 to PDAC metastasis through an EMT axis involving IQGAP1.

    Evidence RNA-binding protein immunoprecipitation, ASO knockdown, EMT marker analysis, and in vitro/xenograft models

    PMID:40539383

    Open questions at the time
    • Direct functional contribution of palladin (vs STAU2's other targets) to metastasis not isolated
    • Mechanistic role of IQGAP1-palladin interaction not detailed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How palladin's lipid-gated actin-bundling biochemistry, its scaffolding interactions, and its emerging nuclear/signaling functions are integrated within a single isoform repertoire across tissues remains unresolved.
  • No unified model linking isoform-specific localization to distinct molecular functions
  • Cellular relevance of PI(4,5)P2 gating across the documented contexts untested
  • Nuclear activity of palladin fragments uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 3 GO:0060090 molecular adaptor activity 3 GO:0008289 lipid binding 1
Localization
GO:0005634 nucleus 2 GO:0005856 cytoskeleton 2 GO:0005829 cytosol 1
Pathway
R-HSA-168256 Immune System 3 R-HSA-162582 Signal Transduction 2 R-HSA-397014 Muscle contraction 1
Partners
ANKRD1FHOD1IQGAP1OCRLSTAT3STAU2

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 The P239S missense mutation in palladin (proline to serine in a conserved region) causes cytoskeletal changes, abnormal actin bundle assembly, and increased cell migration when expressed in HeLa cells, demonstrating a gain-of-function effect on actin organization and motility. Transfection of wild-type and P239S mutant palladin constructs into HeLa cells; phenotypic analysis of actin bundle assembly and migration PLoS medicine Medium 17194196
2007 Palladin knockout (Palld−/−) in mice causes defective definitive erythropoiesis in fetal liver due to a compromised erythropoietic microenvironment; specifically, mutant macrophages lose the ability to bind erythroblasts and fail to form erythroblastic islands, while mutant fetal liver cells can still reconstitute hematopoiesis in irradiated recipients. Palld−/− knockout mouse model; colony-forming assays; in vitro erythroblastic island formation with wild-type vs. mutant macrophages and erythroblasts; bone marrow reconstitution experiments Blood High 17431131
2016 Palladin Ig domains 3 and 34 interact with the head group of PI(4,5)P2 with moderate affinity (apparent Kd ~17 µM); PI(4,5)P2 binding inhibits palladin's actin polymerization and crosslinking/bundling activity. Residues K38 and K51 on β-sheets C and D of Ig3 form salt bridges with PI(4,5)P2, and charge neutralization at K38 severely limits actin polymerizing and bundling activity. In vitro actin polymerization and bundling assays; NMR titration; molecular docking; site-directed mutagenesis (K38 charge neutralization) Journal of molecular biology High 27487483
2017 PALLD regulates phagocytosis by facilitating phagocytic receptor clustering via actin polymerization and c-Src dynamic activation during particle binding and early phagosome formation, and recruits phosphatase OCRL (oculocerebrorenal syndrome of Lowe) to the nascent phagosome to regulate PI(4,5)P2 hydrolysis and actin depolymerization for phagosome closure. PALLD knockdown/overexpression in myeloid leukemia cells; phagocytosis assays (IgG- and complement-opsonized particles); imaging of receptor clustering, c-Src activation, OCRL recruitment, PI(4,5)P2 levels Journal of immunology High 28739877
2013 In Sertoli cells, the 140 kDa palladin isoform is cleaved, with its C-terminus localizing to the nucleus and N-terminus remaining cytoplasmic. Nuclear localization of the C-terminal fragment is regulated by a putative nuclear export signal, and this nuclear translocation coincides with onset of puberty. Immunofluorescence and fractionation of testis tissue; isoform identification by Western blot; nuclear export signal analysis in Sertoli cells Molecular reproduction and development Medium 23559268
2014 PALLD nuclear localization in Sertoli cells is regulated by FSH signaling: PALLD shuttles from nucleus to cytoplasm upon F-actin depolymerization triggered by cAMP signaling, and nuclear localization is reduced in FSH receptor-mutant (but not LH receptor- or androgen receptor-mutant) mice. Primary Sertoli cell culture with serum stimulation; pharmacological F-actin depolymerization; analysis of LH receptor, androgen receptor, and FSH receptor knockout mouse testes by immunofluorescence Reproduction Medium 24989903
2023 Conditional cardiomyocyte-specific ablation of PALLD in adult mice causes progressive cardiac dilation, systolic dysfunction, reduced cardiomyocyte contractility, intercalated disc abnormalities, and fibrosis. Yeast two-hybrid screening identified CARP/Ankrd1 and FHOD1 as novel interaction partners of the N-terminal region of PALLD. Inducible cardiomyocyte-specific PALLD knockout mice (cPKOi); echocardiography; contractility assays; yeast two-hybrid screening; double knockout with MYPN eLife High 36927816
2024 PALLD binds directly to STAT3 via its immunoglobulin domain 3, interacting with STAT3's DNA-binding domain and SH2 domain. Loss of PALLD in megakaryocytes attenuates STAT3 Y705 phosphorylation and impedes STAT3 nuclear translocation, impairing proplatelet formation, polyploidization, and platelet production. A peptide (C-P3) based on the PALLD-STAT3 binding sequence facilitates megakaryocyte differentiation in vivo. Megakaryocyte/platelet-specific Palld knockout mice; Co-IP mapping PALLD Ig3 with STAT3 domains; phospho-STAT3 (Y705) Western blot; STAT3 nuclear translocation imaging; proplatelet formation assays; in vivo peptide rescue Haematologica High 38813732
2021 A germline PALLD mutation (D52N) identified in a familial pancreatic cancer family shows predominant expression in cancer-associated fibroblasts (CAFs) by compartment-specific gene expression analysis and IHC, suggesting a stromal predisposition mechanism for familial pancreatic cancer. Whole exome sequencing of tumor and blood; germline mutation confirmation by PCR; compartment-specific gene expression analysis; immunohistochemistry for PALLD in CAFs JCI insight Medium 33764904
2022 Palladin promotes cancer stem cell-like properties in lung cancer cells by activating Wnt/β-catenin signaling; palladin overexpression increases β-catenin accumulation, and Wnt/β-catenin pathway inhibition blocks palladin-induced sphere-forming enhancement. In vitro overexpression/knockdown in NSCLC cell lines; sphere-forming assays; Western blot for β-catenin; xenograft models; Wnt/β-catenin inhibitor rescue experiments Cancer medicine Medium 36047666
2025 STAU2 RNA-binding protein directly binds and regulates PALLD mRNA, and STAU2 promotes PDAC metastasis via an EMT pathway involving PALLD and IQGAP1; ASO-mediated knockdown of STAU2 suppresses PALLD expression and inhibits PDAC progression in vitro and in vivo. RNA-binding protein immunoprecipitation; ASO knockdown; in vitro and xenograft in vivo models; EMT marker analysis; omics analyses Advanced science Medium 40539383
2020 Palladin promoter regions for the 90 kDa, 140 kDa, and 200 kDa isoforms were identified and contain transcriptional regulatory elements including TATA box, GATA, MyoD, myogenin, MEF, Nkx2-5, and Tcf3 binding sites, with transcriptome profiling confirming active roles for these predicted transcription factors in mouse. Promoter prediction programs; identification of transcription start sites; luciferase reporter assays; transcriptome profiling in mouse BMC research notes Low 32620172
2023 miR-96 and miR-182 downregulate PALLD at both transcript and protein levels in glioblastoma (U251 MG) cells, and overexpression of palladin rescues the inhibition of cell motility caused by miR-96 or miR-182 overexpression, demonstrating that palladin is a functional downstream target of these miRNAs in GBM motility. miRNA overexpression; RT-PCR and Western blot for PALLD; cell motility assays; palladin rescue experiments in miRNA-transfected cells Cytoskeleton Medium 36961307

Source papers

Stage 0 corpus · 59 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. PLoS medicine 162 17194196
2005 Identification of four gene variants associated with myocardial infarction. American journal of human genetics 125 16175505
2011 German national case collection for familial pancreatic cancer (FaPaCa): ten years experience. Familial cancer 117 21207249
2008 Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia. Molecular psychiatry 86 18521091
2007 Five common gene variants identify elevated genetic risk for coronary heart disease. Genetics in medicine : official journal of the American College of Medical Genetics 80 18073581
2010 Polymorphisms inside microRNAs and microRNA target sites predict clinical outcomes in prostate cancer patients receiving androgen-deprivation therapy. Clinical cancer research : an official journal of the American Association for Cancer Research 69 21149617
2008 Genetic predisposition and environmental risk factors to pancreatic cancer: A review of the literature. Mutation research 65 19150414
2012 CDKN2A is the main susceptibility gene in Italian pancreatic cancer families. Journal of medical genetics 61 22368299
2018 Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts. Pancreas 38 30113427
2007 Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver. Blood 37 17431131
2022 Identification and characterization of in vitro expanded hematopoietic stem cells. EMBO reports 36 35971894
2017 Mesenchymal stromal cells (MSCs) induce ex vivo proliferation and erythroid commitment of cord blood haematopoietic stem cells (CB-CD34+ cells). PloS one 30 28231331
2009 Absence of deleterious palladin mutations in patients with familial pancreatic cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 30 19336541
2015 Actin Disorganization Plays a Vital Role in Impaired Embryonic Development of In Vitro-Produced Mouse Preimplantation Embryos. PloS one 26 26076347
2013 Differential proinflammatory and oxidative stress response and vulnerability to metabolic syndrome in habitual high-fat young male consumers putatively predisposed by their genetic background. International journal of molecular sciences 26 23975165
2009 Clinical and genetic analysis of 18 pancreatic carcinoma/melanoma-prone families. Clinical genetics 23 20041885
2007 A genome-wide scan in forty large pedigrees with multiple sclerosis. Journal of human genetics 23 18000641
2020 A NOTCH3 homozygous nonsense mutation in familial Sneddon syndrome with pediatric stroke. Journal of neurology 22 32980981
2020 Effects of germline and somatic events in candidate BRCA-like genes on breast-tumor signatures. PloS one 19 32997669
2019 Survey of allele specific expression in bovine muscle. Scientific reports 16 30862965
2022 Palladin promotes cancer stem cell-like properties in lung cancer by activating Wnt/Β-Catenin signaling. Cancer medicine 14 36047666
2009 Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. International journal of cardiology 14 19709766
2022 Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer in Vitro and in Vivo. Journal of natural products 12 35976233
2020 Uncovering Potential Roles of Differentially Expressed Genes, Upstream Regulators, and Canonical Pathways in Endometriosis Using an In Silico Genomics Approach. Diagnostics (Basel, Switzerland) 12 32575462
2017 Expression quantitative trait loci for PI3K/AKT pathway. Medicine 12 28072738
2016 Phosphoinositide Binding Inhibits Actin Crosslinking and Polymerization by Palladin. Journal of molecular biology 12 27487483
2025 Single-Cell Transcriptomics Identifies Selective Lineage-Specific Regulation of Genes in Aortic Smooth Muscle Cells in Mice. Arteriosclerosis, thrombosis, and vascular biology 11 39744838
2013 Nuclear localization of the actin regulatory protein Palladin in sertoli cells. Molecular reproduction and development 11 23559268
2021 PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer. JCI insight 10 33764904
2021 Gene by environment interaction mouse model reveals a functional role for 5-hydroxymethylcytosine in neurodevelopmental disorders. Genome research 9 34949667
2020 Multiple cancer susceptible genes sequencing in BRCA-negative breast cancer with high hereditary risk. Annals of translational medicine 9 33313162
2017 PALLD Regulates Phagocytosis by Enabling Timely Actin Polymerization and Depolymerization. Journal of immunology (Baltimore, Md. : 1950) 9 28739877
2022 Systematic Identification of the RNA-Binding Protein STAU2 as a Key Regulator of Pancreatic Adenocarcinoma. Cancers 8 35892886
2019 Long Noncoding Ribonucleic Acid MSTRG.59589 Promotes Porcine Skeletal Muscle Satellite Cells Differentiation by Enhancing the Function of PALLD. Frontiers in genetics 8 31850071
2003 Identification of multiple differentially expressed messenger RNAs in normal and pathological trophoblast. Placenta 8 12566248
2024 Archetypal clustering reveals physiological mechanisms linking milk yield and fertility in dairy cattle. Journal of dairy science 7 38369117
2014 Actin dynamics regulate subcellular localization of the F-actin-binding protein PALLD in mouse Sertoli cells. Reproduction (Cambridge, England) 7 24989903
2023 Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities. eLife 6 36927816
2023 Multigene Panel Sequencing Identifies a Novel Germline Mutation Profile in Male Breast Cancer Patients. International journal of molecular sciences 6 37762649
2019 Exome-wide search and functional annotation of genes associated in patients with severe tick-borne encephalitis in a Russian population. BMC medical genomics 6 31122248
2013 TNF-alpha and melphalan modulate a specific group of early expressed genes in a murine melanoma model. Cytokine 6 23534980
2022 Atomic force microscopy identifies the alteration of rheological properties of the cardiac fibroblasts in idiopathic restrictive cardiomyopathy. PloS one 5 36174041
2022 Mechanisms of PALLD, PRKCH, AKAP12, PDK4, and CHIT1 Proteins in Serum Diagnosis of Neonatal Sepsis. Clinical laboratory 5 36377982
2012 Aggregation of Human Eyelid Adipose-derived Stem Cells by Human Body Fluids. Development & reproduction 4 25949109
2025 Unraveling the role of neuregulin-mediated astrocytes-OPCs axis in the pathogenesis of age-related macular degeneration and Parkinson's disease. Scientific reports 3 40025106
2025 Small Cell Transformation of EGFR-Mutant NSCLC Treated with Tyrosine Kinase Inhibition. Current oncology (Toronto, Ont.) 3 41149474
2024 Single-cell RNA sequencing and ATAC sequencing identify novel biomarkers for bicuspid aortic valve-associated thoracic aortic aneurysm. Frontiers in cardiovascular medicine 3 38685981
2023 miR96- and miR182-driven regulation of cytoskeleton results in inhibition of glioblastoma motility. Cytoskeleton (Hoboken, N.J.) 3 36961307
2023 [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 3 37712274
2020 Expression of palladin is associated with disease progression in metastatic high-grade serous carcinoma. Cytopathology : official journal of the British Society for Clinical Cytology 3 32741023
2010 Polymorphism of the palladin gene and cardiovascular outcome in patients with atherosclerosis. European journal of clinical investigation 3 21054356
2024 The role of PALLD-STAT3 interaction in megakaryocyte differentiation and thrombocytopenia treatment. Haematologica 2 38813732
2020 Cloning and promoter analysis of palladin 90-kDa, 140-kDa, and 200-kDa isoforms involved in skeletal muscle cell maturation. BMC research notes 2 32620172
2025 ASO Therapy Targeting STAU2 to Inhibit Pancreatic Ductal Adenocarcinoma Progression and Metastasis by Regulating the PALLD-Mediated EMT Signaling Pathway. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 1 40539383
2025 An integrated approach for key gene selection and cancer phenotype classification: Improving diagnosis and prediction. Computers in biology and medicine 1 40618695
2025 Unraveling the role of gut microbiota on the formation of nephrolithiasis: insights from integrated analysis of GWAS, single-cell transcriptomics, bulk RNA sequencing and network Pharmacology. Urolithiasis 1 40664942
2023 Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people. Archives of medical science : AMS 1 37732072
2026 Berry-derived gold nanoparticles induce integrated ROS-mediated apoptosis, immune modulation, and transcriptomic remodeling in 4T1 triple-negative cancer cells. Cell death discovery 0 41963310
2025 Identification of blood-derived DNA methylation biomarkers of glaucoma and intraocular pressure measurements in three European ancestry cohorts including the Canadian longitudinal study on aging. Epigenetics 0 41105805

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