Affinage

FTH1

Ferritin heavy chain · UniProt P02794

Length
183 aa
Mass
21.2 kDa
Annotated
2026-06-09
100 papers in source corpus 37 papers cited in narrative 37 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/6 claims corpus-supported (83%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FTH1 encodes the ferroxidase heavy-chain subunit of ferritin, which assembles into higher-order 24-mer cages that sequester redox-active iron and thereby restrain ROS production and ferroptotic cell death (PMID:26886577, PMID:34965856, PMID:34445601). By oxidizing and storing labile Fe2+, FTH1 functions as a central brake on the ferritinophagy–ferroptosis cycle: its turnover is governed by autophagic degradation through direct binding to the cargo receptor NCOA4, and disrupting the NCOA4–FTH1 interaction blocks ferritinophagy and the release of bioavailable iron (PMID:32959272, PMID:34235259, PMID:40749519). FTH1 protein stability is further set by competing post-translational machinery—the E3 ligase SMURF1 drives its ubiquitination and degradation, while the chaperone CRYAB protects it from proteasomal turnover in a lactylation-dependent manner (PMID:39941157, PMID:38787373); upstream, deubiquitination of NCOA4 by OTULIN and recruitment by LCN2 tune the rate of ferritinophagic FTH1 loss (PMID:40158433, PMID:39613734). FTH1 abundance is set transcriptionally by activators including MAZ, NUPR1, and MBD5/KAT2A and repressed by TFEB and by estrogen-driven PRMT5/DNMT3B promoter methylation (PMID:36164395, PMID:38802795, PMID:24750026, PMID:37851191, PMID:32476555), and post-transcriptionally through 3'-UTR binding by RSL1D1 and a dense epitranscriptomic layer in which m6A (METTL14/FTO) and m7G (METTL1) marks, read by YTHDF1, control FTH1 mRNA stability and translation (PMID:36913375, PMID:38738555, PMID:39848345, PMID:38040806). Through these controls FTH1 sets ferroptosis sensitivity across many cell types, acting as a tumor suppressor upstream of c-MYC in breast cancer and restraining a ROS/HIF-1α/CXCR4/NF-κB invasion axis in leukemia (PMID:34551213, PMID:32432042). Heterozygous C-terminal nonsense variants (e.g. p.Phe171*) escape nonsense-mediated decay, elevate ferritin protein, disrupt the 4-fold pores, and cause disease through a dominant toxic gain-of-function mechanism (PMID:37660254).

Mechanistic history

Synthesis pass · year-by-year structured walk · 33 steps
  1. 2002 Medium

    Established that an FTH1-derived placental variant (PLIF) carries immunomodulatory activity distinct from canonical iron storage, hinting at functions beyond ferritin assembly.

    Evidence cDNA cloning, immunolocalization, and in vitro lymphocyte proliferation assays from placenta

    PMID:11821435

    Open questions at the time
    • PLIF is a C-terminally substituted variant, not full-length FTH1
    • mechanism of lymphocyte suppression not resolved
  2. 2003 Medium

    Dissected the signaling route by which the FTH1-derived C48 domain elicits IL-10, defining a calcium/calmodulin-p38 MAPK pathway.

    Evidence Cytokine ELISA with calmodulin and p38 inhibitors in monocytes

    PMID:12670872

    Open questions at the time
    • pertains to the PLIF variant rather than canonical FTH1
    • receptor for C48 unidentified
  3. 2011 Medium

    Showed FTH1 has a direct protein-interaction role in apoptosis control by binding Daxx and suppressing Fas-Daxx-ASK1-JNK1 signaling, beyond its iron-storage function.

    Evidence Yeast two-hybrid, GST pull-down, Co-IP, and JNK pathway assays

    PMID:21573799

    Open questions at the time
    • interaction interface not mapped
    • physiological relevance in vivo untested
  4. 2014 High

    Defined transcriptional control of Fth1 in vivo, showing MBD5 enhances Fth1 transcription via KAT2A-dependent histone acetylation to prevent iron overload.

    Evidence Conditional knockout mice, luciferase promoter assay, histone acetylation analysis

    PMID:24750026

    Open questions at the time
    • direct MBD5 promoter occupancy not shown
    • tissue specificity beyond intestine unaddressed
  5. 2016 Medium

    Confirmed that human FTH1 self-assembles into 24-mer cages and confers cytoprotection against pro-death and metal stress, validating its core antioxidant/storage role.

    Evidence Heterologous expression in yeast, EM, viability assays

    PMID:26886577

    Open questions at the time
    • non-mammalian system
    • ferroxidase kinetics not measured
  6. 2020 Medium

    Placed FTH1 as a central node of the ferritinophagy-ferroptosis cycle, where its overexpression impairs NCOA4-dependent ferritin degradation and suppresses ferroptosis.

    Evidence siRNA/overexpression, autophagy inhibitors, mitochondrial assays in PC-12 cells

    PMID:32959272

    Open questions at the time
    • direct FTH1-NCOA4 binding not assayed in this study
    • single neuronal cell line
  7. 2020 Medium

    Linked FTH1 loss to a pro-invasive program, showing FTH knockdown raises ROS and drives a HIF-1α/CXCR4/NF-κB EMT-like axis in leukemia.

    Evidence Stable shRNA, motility assays, pharmacological rescue (NAC/AMD3100/IκB inhibitor)

    PMID:32432042

    Open questions at the time
    • axis correlative downstream of ROS
    • single cell line
  8. 2020 Medium

    Demonstrated epigenetic silencing of FTH1 by estrogen via PRMT5-dependent DNA methylation, connecting hormonal signaling to ferritin levels in liver cancer.

    Evidence ChIP, siRNA knockdown, methylation and demethylation rescue

    PMID:32476555

    Open questions at the time
    • direct DNMT3B-PRMT5 cooperation mechanism not resolved
    • single tumor type
  9. 2021 High

    Pinpointed NCOA4 as the druggable interaction target upstream of FTH1, with a small molecule directly disrupting NCOA4-FTH1 binding to block ferritinophagy and ferroptosis.

    Evidence Recombinant protein binding, PPI disruption, ferroptosis and stroke models

    PMID:34235259

    Open questions at the time
    • binding interface residues not mapped
    • selectivity of the compound beyond NCOA4 untested
  10. 2021 Medium

    Confirmed FTH1 ferroxidase function determines ferroptosis sensitivity across tumor contexts, with overexpression reducing ROS and inducing GPX4 while abrogating ferroptosis-based therapy.

    Evidence Overexpression, ROS/lipid peroxide measurement, Seahorse, GPX4 blots, xenografts

    PMID:34445601 PMID:34965856

    Open questions at the time
    • mechanistic link between FTH1 and GPX4 induction unresolved
    • correlative in single labs
  11. 2021 Medium

    Established FTH1 as a tumor suppressor upstream of c-MYC in breast cancer through epistasis between FTH1 and c-MYC manipulation.

    Evidence siRNA/overexpression, proliferation, mammosphere, c-MYC blots

    PMID:34551213

    Open questions at the time
    • mechanism linking FTH1 to c-MYC not defined
    • single cancer type
  12. 2018 Medium

    Revealed a ceRNA layer controlling FTH1, where FTH1 pseudogenes sponge oncogenic miRNAs to protect FTH1 mRNA and regulate intracellular iron.

    Evidence miRNA screen, luciferase reporters, growth assays, xenografts

    PMID:29240947

    Open questions at the time
    • relative contribution of individual pseudogenes unclear
    • single cancer type
  13. 2022 Medium

    Uncovered an m5C methylation mechanism for FTH1/FTL mRNA, with NSUN5 (aided by TRAP1) marking the transcripts to sustain FTH1 protein and restrain ferroptosis.

    Evidence RIP, Co-IP, m5C assays, overexpression/knockdown in BMSCs

    PMID:35249107

    Open questions at the time
    • m5C reader for FTH1 not identified
    • single cell system
  14. 2022 Medium

    Identified MAZ as a direct transcriptional activator of FTH1 within a lncRNA TUG1/MAZ/FTH1 axis modulating ferroptosis in glioma.

    Evidence ChIP, luciferase, overexpression/knockdown, in vivo ferroptosis assays

    PMID:36164395

    Open questions at the time
    • other MAZ target contributions not excluded
    • single tumor type
  15. 2022 Medium

    Positioned SIRT6 as a common upstream node coordinating both NCOA4/FTH1 ferritinophagy and Nrf2/GPX4 arms of ferroptosis defense.

    Evidence SIRT6 knockdown/overexpression in cells and rats, ferroptosis markers

    PMID:36463827

    Open questions at the time
    • direct SIRT6 targets in these arms not defined
    • correlative pathway placement
  16. 2022 Medium

    Extended FTH1 biology to non-cell-autonomous damage, showing microglia secrete FTH1-containing exosomes that promote neuronal lipid peroxidation.

    Evidence Conditioned medium/exosome isolation, lipid peroxidation assays, Fth1 knockdown

    PMID:35368870

    Open questions at the time
    • mechanism of FTH1 loading into exosomes unknown
    • redox role of secreted FTH1 not biochemically defined
  17. 2023 High

    Defined a Mendelian disease mechanism: C-terminal FTH1 nonsense variants escape NMD, disrupt the 4-fold pores, and cause a dominant toxic gain-of-function with elevated ferritin and oxidative stress.

    Evidence Exome sequencing, patient fibroblast assays, ASO knockdown rescue across five patients

    PMID:37660254

    Open questions at the time
    • organ-level pathophysiology in patients not fully characterized
    • structural pore disruption inferred, not solved structurally
  18. 2023 Medium

    Identified RSL1D1 as a 3'-UTR-binding stabilizer of FTH1 mRNA linking FTH1 abundance to ferroptosis and senescence.

    Evidence RIP, siRNA knockdown, Fe2+/MDA/GPX4 readouts in colorectal cancer

    PMID:36913375

    Open questions at the time
    • RSL1D1 binding motif on FTH1 UTR not mapped
    • single cancer type
  19. 2023 Medium

    Resolved m7G control of FTH1, where METTL1 raises FTH1 mRNA but suppresses its translation and matures a miR-26a that further represses FTH1 to promote ferroptosis.

    Evidence AlkAniline-Seq, blots, miRNA manipulation, xenograft

    PMID:38040806

    Open questions at the time
    • mechanism of translation suppression by m7G not fully defined
    • single tumor type
  20. 2023 Medium

    Established TFEB as a direct transcriptional repressor of FTH1 that drives ferritinophagy downstream of PTPRC loss.

    Evidence Luciferase, ChIP, siRNA knockdown in osteosarcoma

    PMID:37851191

    Open questions at the time
    • TFEB direct vs autophagy-program-mediated effect not fully separated
    • single tumor type
  21. 2023 Medium

    Showed autophagic FTH1 degradation underlies a therapeutic vulnerability, with AKT1 loss raising autophagy flux to deplete FTH1 and sensitize resistant ovarian cancer to ferroptosis.

    Evidence AKT1 knockdown, autophagy flux and FTH1 protein assays

    PMID:37011414

    Open questions at the time
    • NCOA4-dependence not directly tested here
    • single resistance model
  22. 2023 Medium

    Connected myeloid FTH1 to inflammatory signaling, placing it upstream of a DMT1-iron-STAT3 axis in colitis.

    Evidence Myeloid-specific FTH1 cKO, DSS colitis, STAT3 pharmacology

    PMID:36745026

    Open questions at the time
    • mechanistic link from FTH1 to DMT1 unresolved
    • ferroptosis contribution not isolated
  23. 2024 Medium

    Defined opposing epitranscriptomic regulators of FTH1: METTL14-deposited m6A destabilizes FTH1 mRNA, while FTO erases m6A and YTHDF1/2 read it to control FTH1 expression and ferroptosis.

    Evidence Luciferase/qRT-PCR (METTL14) and MeRIP/RIP (FTO, YTHDF1/2) with functional assays

    PMID:38738555 PMID:39848345

    Open questions at the time
    • context-dependence of reader outcome (stability vs translation) not reconciled
    • single tissue per study
  24. 2024 Medium

    Defined post-translational protein-stability control of FTH1 by competing machinery: CRYAB protects FTH1 from proteasomal degradation via lactylation, while SMURF1 ubiquitinates FTH1 for degradation, governing ferroptosis and differentiation.

    Evidence IP-MS/Co-IP, proteasome inhibitors (CRYAB); Co-IP ubiquitination and muscle cKO (SMURF1)

    PMID:38787373 PMID:39941157

    Open questions at the time
    • ubiquitination sites on FTH1 not mapped
    • interplay between CRYAB and SMURF1 not tested together
  25. 2024 Medium

    Identified NUPR1 as a direct transcriptional activator of FTH1 conferring ferroptosis resistance via a circPIAS1/miR-455-3p/NUPR1 axis in HCC.

    Evidence RIP, luciferase, RNA pulldown, FISH, ChIP, xenograft

    PMID:38802795

    Open questions at the time
    • NUPR1 promoter binding site on FTH1 not detailed
    • single cancer type
  26. 2024 Medium

    Extended upstream control of ferritinophagy to LCN2, which interacts with NCOA4 under high phosphate to accelerate FTH1 degradation and ferroptosis in vascular calcification.

    Evidence Co-IP, LCN2 KO/OE mice, ferroptosis/calcification markers

    PMID:39613734

    Open questions at the time
    • LCN2 effect on NCOA4-FTH1 binding is indirect/inferred
    • phosphate-dependence mechanism unclear
  27. 2024 Medium

    Showed FTH1 protects cartilage by limiting ferroptosis and suppressing MAPK signaling in osteoarthritis.

    Evidence Chondrocyte knockdown, adenoviral overexpression in DMM model, MAPK blots

    PMID:38609896

    Open questions at the time
    • mechanistic link from FTH1 to MAPK unresolved
    • single disease model
  28. 2024 Medium

    Validated FTH1 as a direct druggable protein target, with CT-1 binding FTH1 to trigger NCOA4-mediated ferritinophagy and ferroptosis in tumors.

    Evidence Target identification, overexpression rescue, in vivo tumor model

    PMID:39809268

    Open questions at the time
    • binding site on FTH1 not mapped
    • selectivity not fully profiled
  29. 2025 Medium

    Implicated OTULIN deubiquitination of NCOA4 as a control point that indirectly sets FTH1 levels and hepatocyte ferroptosis.

    Evidence OTULIN stable lines, ubiquitination assays, APAP mouse model

    PMID:40158433

    Open questions at the time
    • direct OTULIN-NCOA4 enzymology not fully characterized
    • single injury model
  30. 2025 Medium

    Connected mechanical tension to iron handling via FTH1 phase separation, showing low tension raises FTH1 and suppresses NCOA4-driven ferritinophagy and ferroptosis.

    Evidence Tension manipulation, NCOA4 knockdown, phase separation imaging

    PMID:39988734

    Open questions at the time
    • molecular sensor coupling tension to NCOA4 unidentified
    • physiological generality unclear
  31. 2025 Medium

    Added a further epitranscriptomic relay, the Alkbh5-Ythdf1-Fth1 axis, promoting FTH1 translation to inhibit cardiomyocyte ferroptosis.

    Evidence MeRIP, RIP, reciprocal knockdown, H/R and MIRI rat models

    PMID:40251485

    Open questions at the time
    • direct vs Ythdf1-mediated FTH1 regulation by Alkbh5 not separated
    • single disease context
  32. 2025 Medium

    Revealed a nuclear function for FTH1, where it associates with BRD2 to support its stability and suppress ferroptosis-related gene expression in aggressive NSCLC.

    Evidence Co-IP across NSCLC cell lines, siRNA silencing, ferroptosis markers

    PMID:40652527

    Open questions at the time
    • nuclear import mechanism of FTH1 unknown
    • interaction specificity to BRD2 vs BRD4 mechanistically unexplained
  33. 2025 High

    Provided strong validation of NCOA4-FTH1 disruption as a neuroprotective strategy, showing DMM blocks the interaction, inhibits ferritinophagy, and protects in an FTH1-dependent manner.

    Evidence Co-IP, FTH1-LAMP2 imaging, Fth1 knockdown rescue, neonatal MCAO model

    PMID:40749519

    Open questions at the time
    • DMM target specificity beyond the NCOA4-FTH1 interaction not fully resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the dense, partly redundant regulatory layers (transcriptional, epitranscriptomic, ubiquitin/chaperone, and ferritinophagic) are integrated in a single cell to set FTH1 levels, and how nuclear/secreted FTH1 pools relate mechanistically to the cytosolic iron-storage cage, remain unresolved.
  • no unified model reconciling competing regulators in one system
  • ferroxidase enzymology of human FTH1 not directly measured in the corpus
  • structural basis of nuclear FTH1-BRD2 and exosomal FTH1 unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016491 oxidoreductase activity 3 GO:0140313 molecular sequestering activity 3 GO:0005198 structural molecule activity 2
Localization
GO:0005829 cytosol 2 GO:0005634 nucleus 1 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-5357801 Programmed Cell Death 4 R-HSA-8953854 Metabolism of RNA 4 R-HSA-9612973 Autophagy 4 R-HSA-1430728 Metabolism 3
Partners
BRD2CRYABDAXXNCOA4NSUN5RSL1D1SMURF1YTHDF1
Complex memberships
ferritin (heteropolymer with FTL)

Evidence

Reading pass · 37 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 PLIF (an FTH1-related protein from placenta) is composed of the FTH1 ferritin heavy chain sequence lacking the 65 C-terminal amino acids substituted with a novel 48 amino acid domain (C48); unlike FTH1, PLIF mRNA lacks the iron response element in the 5'-UTR, indicating iron-independent synthesis; PLIF localizes to syncytiotrophoblasts at the fetal-maternal interface and inhibits peripheral blood mononuclear cell proliferation and mixed lymphocyte reactions in vitro. cDNA cloning, immunolocalization, in vitro lymphocyte proliferation assay The Journal of biological chemistry Medium 11821435
2003 The C48 domain of PLIF (the FTH1-derived immunomodulatory ferritin) induces IL-10 production in monocytes through a calcium/calmodulin-p38 MAP kinase signaling pathway; ERK1/2, also activated by C48, exerts a limiting effect on IL-10 production. Cytokine ELISA, pharmacological inhibitors of calmodulin and p38 MAPK FASEB journal Medium 12670872
2011 FTH1 physically interacts with the apoptosis regulator Daxx, as demonstrated by yeast two-hybrid screening, GST pull-down, and co-immunoprecipitation; FTH1 inhibits Daxx-mediated apoptosis by suppressing activation of the Fas-Daxx-ASK1-JNK1 signaling pathway. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, JNK pathway activity assays Molecular biology reports Medium 21573799
2014 MBD5 regulates Fth1 transcription in the intestine through the histone acetyltransferase KAT2A: MBD5 deletion reduces histone H4 acetylation at the Fth1 promoter, decreases intestinal Fth1 mRNA, and causes iron overload in mice; Fth1 promoter-reporter assays show MBD5 enhances Fth1 transcription in a dose-dependent manner. Conditional knockout mice, luciferase promoter assay, chromatin histone acetylation analysis, serum/liver iron measurements British journal of haematology High 24750026
2016 Human FTH1, when heterologously expressed in S. cerevisiae, forms higher-order (24-mer) structures visible by electron microscopy and SDS-PAGE, suppresses Bax-induced cell death, and confers resistance to copper-induced cell death, consistent with its iron-storage and antioxidant function. Heterologous expression in yeast, electron microscopy, cell viability assays with pro-apoptotic stimuli Experimental cell research Medium 26886577
2018 The FTH1 transcript and multiple FTH1 pseudogenes are targeted by oncogenic miRNAs in prostate cancer; pseudogene transcripts act as competing endogenous RNAs (ceRNAs) to sequester these miRNAs and protect FTH1 mRNA; disruption of this ceRNA crosstalk rescues the slow-growth phenotype in vitro and in vivo, and FTH1/pseudogene levels reciprocally regulate intracellular iron. Unbiased miRNA screen, luciferase reporter assays, in vitro growth assays, xenograft mouse models Nucleic acids research Medium 29240947
2020 Estrogen (E2) silences FTH1 expression in liver cancer cells (Hep-G2, Huh7) via DNA methylation; PRMT5 is recruited to the FTH1 promoter (shown by ChIP), and knockdown of PRMT5, DNMT3B, or estrogen receptor alpha rescues FTH1 from E2-induced silencing; this epigenetic silencing reduces liver cancer cell growth. ChIP, siRNA knockdown, DNA methylation assays, 5-Aza-2-deoxycytidine demethylation rescue Epigenetics Medium 32476555
2020 FTH1 overexpression in PC-12 cells impairs ferritinophagy, downregulates LC3 and NCOA4, and suppresses ferroptotic cell death induced by 6-OHDA; knockdown of FTH1 reduces cell viability and causes mitochondrial dysfunction; ferritinophagy inhibitors chloroquine and bafilomycin A1 block ferritin degradation and ferroptosis, placing FTH1 as a central regulator of the ferritinophagy-ferroptosis cycle. siRNA knockdown, overexpression, Western blot, pharmacological inhibitors of autophagy, mitochondrial function assays Neurotherapeutics Medium 32959272
2020 FTH knockdown in K562 erythroleukemia cells increases ROS, upregulates HIF-1α, which drives CXCR4 expression and CXCL12-mediated cell motility; FTH knockdown also promotes an EMT-like phenotype (increased Snail, Slug, Vimentin; decreased E-cadherin); N-acetylcysteine, AMD3100, or NF-κB inhibition reverses the invasive phenotype, placing FTH at the top of a ROS/HIF-1α/CXCR4/NF-κB axis. Stable shRNA knockdown, confocal microscopy, cell adhesion and motility assays, pharmacological rescue with NAC/AMD3100/IκB inhibitor Frontiers in oncology Medium 32432042
2021 Compound 9a directly binds recombinant NCOA4383-522 and disrupts the NCOA4-FTH1 protein-protein interaction, reducing bioavailable intracellular Fe2+ and blocking ferroptosis; this identifies NCOA4 as the molecular target through which ferritinophagy is regulated upstream of FTH1. Recombinant protein binding assay, protein-protein interaction disruption assay, ferroptosis cell death assay, rat ischemic stroke model ACS central science High 34235259
2021 FTH1 overexpression in HCC cells abrogates ferroptosis-inducing anticancer effects, reduces mitochondrial ROS, attenuates impaired mitochondrial respiration, and rescues mitochondrial homeostasis, consistent with FTH1's ferroxidase activity sequestering redox-active Fe2+. FTH1 overexpression, ROS/lipid peroxide measurement (DCF-DA, C11-BODIPY), Seahorse mitochondrial respiration assay, xenograft in vivo Cancer cell international Medium 34965856
2021 FTH1 expression is lower in neuroblastoma N2A cells than in normal neural stem cells; ectopic FTH1 expression reduces ROS, reduces ferroptosis-induced cell death, and induces GPX4 expression in N2A cells, establishing FTH1's ferroxidase function as a determinant of ferroptosis sensitivity. Ectopic FTH1 overexpression, ROS measurement, cell viability assay, GPX4 Western blot International journal of molecular sciences Medium 34445601
2021 FTH1 silencing in breast cancer cells promotes cell growth and c-MYC expression, reduces chemotherapy sensitivity, and promotes mammosphere formation; conversely, FTH1 overexpression inhibits growth, decreases c-MYC, and sensitizes cells to chemotherapy; silencing c-MYC recapitulates FTH1 overexpression effects, placing FTH1 upstream of c-MYC as a tumor suppressor in breast cancer. siRNA silencing, overexpression, proliferation assay, mammosphere formation, Western blot for c-MYC FEBS open bio Medium 34551213
2022 NSUN5 binds FTH1/FTL mRNA (shown by RNA immunoprecipitation), and NSUN5 depletion reduces 5-methylcytosine (m5C) on FTH1/FTL mRNA, decreases FTH1 protein, increases intracellular iron, and promotes ferroptosis in BMSCs; the recognition of FTH1/FTL by NSUN5 requires TRAP1 recruitment (shown by Co-IP). RNA immunoprecipitation, Co-immunoprecipitation, m5C methylation assay, FTH1/FTL overexpression/knockdown, ferroptosis markers Cell death discovery Medium 35249107
2022 SIRT6 acts as an upstream regulator of both phosphorylated Nrf2 (which controls GPX4) and NCOA4 (which controls FTH1 ferritinophagy); melatonin inhibits ferroptosis through the SIRT6/NCOA4/FTH1 and SIRT6/p-Nrf2/GPX4 pathways, positioning SIRT6 as a common upstream node. Genetic engineering knockdown/overexpression of SIRT6 in cells and rats, Western blot, immunofluorescence, ferroptosis markers Biomedicine & pharmacotherapy Medium 36463827
2022 MAZ (MYC-associated zinc finger protein) transcriptionally activates FTH1 by binding to the FTH1 promoter (confirmed by ChIP assay); lncRNA TUG1 directly targets MAZ (confirmed by luciferase assay); this TUG1/MAZ/FTH1 axis attenuates DHA-induced ferroptosis in glioma cells. ChIP assay, luciferase assay, FTH1 overexpression/knockdown, in vitro and in vivo ferroptosis assays Oxidative medicine and cellular longevity Medium 36164395
2022 NCOA4 binding to FTH1 links ferritin to LC3II in lysosomes to trigger ferritinophagy; caryophyllene oxide promotes ferritinophagy by regulating NCOA4, FTH1, and LC3II levels, resulting in intracellular iron accumulation and ferroptosis in hepatocellular carcinoma cells. Western blot, immunofluorescence, in vivo tumor model with iron/MDA measurements Frontiers in pharmacology Low 35899120
2023 Heterozygous nonsense variants in FTH1 (especially p.Phe171*) escape nonsense-mediated decay, and patient-derived fibroblasts show elevated ferritin protein levels, increased oxidative stress markers, and increased susceptibility to iron accumulation; C-terminal truncation disrupts the E-helix and 4-fold symmetric pores of the ferritin heteropolymer, likely diminishing iron-storage capacity; the pathogenic mechanism is dominant toxic gain-of-function. Whole-exome sequencing, patient fibroblast ferritin expression assays, oxidative stress assays, iron accumulation assays, antisense oligonucleotide knockdown rescue HGG advances High 37660254
2023 RSL1D1 RNA-binding protein directly binds the 3' UTR of FTH1 mRNA (shown by RIP assay) and stabilizes it; RSL1D1 knockdown decreases FTH1 expression, elevates intracellular Fe2+, increases MDA, and reduces GPX4, inducing ferroptosis and cellular senescence in colorectal cancer cells. RNA immunoprecipitation (RIP), siRNA knockdown, Fe2+ measurement, MDA/GPX4 Western blot Carcinogenesis Medium 36913375
2023 METTL1-mediated m7G methylation of FTH1 mRNA increases FTH1 mRNA expression but suppresses FTH1 translation; METTL1 also promotes maturation of pri-miR-26a via m7G methylation, and the resulting mature miR-26a-5p targets FTH1 mRNA to further reduce FTH1 translation efficiency, thereby promoting ferroptosis and osteosarcoma chemosensitivity. AlkAniline-Seq for m7G sites, Western blot, qPCR, miRNA overexpression/knockdown, in vivo xenograft Oncogene Medium 38040806
2023 TFEB transcriptionally inactivates FTH1: PTPRC knockdown promotes TFEB phosphorylation and nuclear translocation, which suppresses FTH1 mRNA expression and promotes ferritinophagy and ferroptosis in osteosarcoma cells; TFEB binding sites on the FTH1 promoter were confirmed by JASPAR prediction and luciferase + ChIP assays. Luciferase reporter assay, ChIP assay, PTPRC siRNA knockdown, Western blot, immunofluorescence Molecular biotechnology Medium 37851191
2023 AKT1 loss in cisplatin-resistant ovarian cancer cells increases autophagy flux, leading to increased autophagic degradation of FTH1, which reduces ferritin-bound iron stores and increases ferroptosis susceptibility; elevated autophagy (not weakened classical ferroptosis defenses) is the mechanism linking DDP-resistance to ferroptosis vulnerability. AKT1 knockdown, autophagy flux assays, FTH1 protein measurement, ferroptosis marker assays Biochemistry and cell biology Medium 37011414
2023 FTH1 deficiency in myeloid cells reduces DMT1 (iron importer) expression and active phospho-STAT3 in colon tissue; pharmacological STAT3 reactivation restores disease susceptibility in myeloid FTH1-KO mice, placing FTH1 upstream of a DMT1-iron-STAT3 signaling axis in colitis pathogenesis. Myeloid-specific FTH1 conditional knockout, DSS colitis model, STAT3 inhibitor/activator pharmacology, Western blot Inflammatory bowel diseases Medium 36745026
2024 METTL14 directly targets FTH1 mRNA for m6A methylation, reducing FTH1 mRNA stability and protein expression (validated by luciferase reporter assay and qRT-PCR); this reduction in FTH1 enhances sorafenib-induced ferroptosis in cervical cancer cells in vitro and in vivo. Luciferase reporter assay, qRT-PCR, siRNA/overexpression, xenograft model Cancer biology & therapy Medium 38738555
2024 CRYAB (αB-crystallin) physically interacts with FTH1 (shown by IP-MS and Co-IP) and maintains FTH1 protein stability via the proteasome in a lactylation-dependent manner; CRYAB knockdown leads to FTH1 degradation, increased cellular Fe2+ and ROS, ferroptosis, and impaired osteogenic differentiation of BMSCs. IP-MS, Co-immunoprecipitation, proteasome inhibitor assay, FTH1 overexpression rescue, osteogenic differentiation markers Aging Medium 38787373
2024 NUPR1 transcriptionally promotes FTH1 expression; in HCC, circPIAS1 acts as a ceRNA for miR-455-3p, releasing NUPR1, which then drives FTH1 transcription to enhance iron storage and confer ferroptosis resistance. RNA immunoprecipitation, luciferase reporter assay, RNA pulldown, FISH, ChIP, Western blot, xenograft Molecular cancer Medium 38802795
2024 LCN2 (lipocalin-2) interacts with NCOA4 under high-phosphate conditions (shown by co-IP), potentially accelerating FTH1 degradation via ferritinophagy and inducing ferroptosis in VSMCs; LCN2 knockout rescues FTH1 levels and reduces ferroptosis and vascular calcification in CKD mice. Co-immunoprecipitation, LCN2 knockout mice, LCN2 overexpression, ferroptosis/vascular calcification markers Cell death & disease Medium 39613734
2024 SMURF1 acts as an E3 ubiquitin ligase for FTH1, facilitating its ubiquitination and degradation; conditional knockout of FTH1 in skeletal muscle causes muscle atrophy, Fe2+ accumulation, GSH depletion, and lipid peroxidation consistent with ferroptosis; SMURF1-mediated FTH1 degradation impedes myoblast differentiation into myotubes. Co-immunoprecipitation for ubiquitination, conditional knockout of FTH1 in muscle, in vitro myoblast differentiation assay, ferroptosis markers International journal of molecular sciences Medium 39941157
2024 FTH1 overexpression reduces chondrocyte susceptibility to ferroptosis and reverses extracellular matrix degradation and SOX9/aggrecan loss after DMM surgery; FTH1 relieves OA by inhibiting the chondrocyte MAPK pathway. FTH1 siRNA knockdown in chondrocytes, adenovirus FTH1 overexpression in DMM mouse model, Western blot for MAPK pathway, cartilage damage scoring BMC musculoskeletal disorders Medium 38609896
2024 FTO (m6A eraser) demethylates FTH1 mRNA; FTO inhibition increases m6A modification on FTH1 mRNA (confirmed by MeRIP), and both YTHDF1 and YTHDF2 bind FTH1 mRNA (confirmed by RIP) to regulate its expression; loss of FTO reduces FTH1 protein and promotes ferroptosis in spermatogenic cells. MeRIP assay, RIP assay, FTO knockdown, FTH1 expression measurement, ferroptosis markers Free radical biology & medicine Medium 39848345
2024 CT-1 (cryptotanshinone derivative) directly targets FTH1 protein, triggering the NCOA4-ferritin interaction and ferritinophagy-mediated ferroptosis in both N2-TANs and TNBC cells; FTH1 is identified as the direct binding target of CT-1. Target identification assays, FTH1 overexpression rescue, ferroptosis marker assays, in vivo tumor model Cell reports. Medicine Medium 39809268
2024 OTULIN deubiquitinase regulates NCOA4 ubiquitination; OTULIN depletion leads to NCOA4 accumulation, FTH1 degradation (ferritinophagy), and hepatocyte ferroptosis in APAP-induced injury; OTULIN overexpression conversely depletes NCOA4 and accumulates FTH1, protecting against ferroptosis. OTULIN stable cell lines, ubiquitination assays, Western blot for NCOA4/FTH1, ferroptosis markers in vivo (APAP mouse model) International immunopharmacology Medium 40158433
2025 Mechanical tension regulates intracellular free iron via the NCOA4-FTH1 axis: reduced mechanical tension increases FTH1 protein expression and decreases NCOA4, suppressing FTH1 phase separation-driven ferritinophagy and ferroptosis; targeting NCOA4 rescues ferroptosis susceptibility under low mechanical tension. Mechanical tension manipulation, FTH1 protein expression assay, NCOA4 knockdown, phase separation imaging, ferroptosis marker assays Autophagy Medium 39988734
2025 Alkbh5 (m6A eraser) demethylates Ythdf1 mRNA, increasing Ythdf1 expression, which then promotes Fth1 translation; Ythdf1 knockdown reverses the anti-ferroptotic effects of Alkbh5 overexpression, placing the Alkbh5-Ythdf1-Fth1 axis as a regulatory pathway inhibiting ferroptosis in cardiomyocytes. MeRIP assay, RIP assay, Alkbh5/Ythdf1 overexpression/knockdown, Fth1 protein level measurement, ferroptosis markers in H/R cell model and MIRI rat model BMC cardiovascular disorders Medium 40251485
2025 Nuclear FTH1 associates with BRD2 (not BRD4) in NSCLC cell lines, affecting BRD2 protein stability only in aggressive NSCLC subtypes; FTH1 silencing in JQ1-insensitive cells triggers ferroptosis and downregulates GPX4, SLC7A11, and SLC3A2, revealing a BRD2-FTH1 nuclear functional interaction that suppresses ferroptosis. Co-immunoprecipitation in a panel of NSCLC cell lines, FTH1 siRNA silencing, ferroptosis marker assays, BRD2/BRD4 protein stability assays The FEBS journal Medium 40652527
2025 DMM (dimethyl malonate) disrupts the NCOA4-FTH1 protein-protein interaction in brain cortex (shown by Co-IP), suppresses NCOA4 and LC3II while upregulating FTH1 and p62, inhibits ferritinophagy and lysosomal Fe2+ accumulation, and protects against ferroptosis in neonatal HIBD; the anti-ferroptotic effects of DMM require FTH1 (reversed by Fth1 knockdown). Co-immunoprecipitation, Western blot, immunofluorescence (FTH1-LAMP2 colocalization), Fth1 knockdown rescue, neonatal MCAO mouse model Redox biology High 40749519
2022 Neurofilament light chain (NF-L) treatment of microglia triggers secretion of FTH1-containing exosomes; these exosomes induce neuronal membrane lipid peroxidation and neuronal loss; blocking Fth1 expression attenuates this oxidative damage, showing that secreted/exosomal FTH1 can promote ferroptosis-like oxidative damage in a non-cell-autonomous manner. Microglia-neuron co-culture/conditioned medium, exosome isolation, CKK8 cell death assay, C11-Bodipy lipid peroxidation assay, Fth1 siRNA knockdown Oxidative medicine and cellular longevity Medium 35368870

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2021 Inhibiting Ferroptosis through Disrupting the NCOA4-FTH1 Interaction: A New Mechanism of Action. ACS central science 427 34235259
2020 FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 363 32959272
2007 Neurologic impairment from ectopic bone in the lumbar canal: a potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2). The spine journal : official journal of the North American Spine Society 266 18037352
2021 Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1. Acta pharmaceutica Sinica. B 232 35024325
2021 Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis. Bioactive materials 151 35224289
2022 Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 131 36463827
2022 Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner. Nature communications 111 36513690
2022 The NSUN5-FTH1/FTL pathway mediates ferroptosis in bone marrow-derived mesenchymal stem cells. Cell death discovery 94 35249107
2021 FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis. Cancer cell international 92 34965856
2018 A FTH1 gene:pseudogene:microRNA network regulates tumorigenesis in prostate cancer. Nucleic acids research 79 29240947
2022 Caryophyllene Oxide Induces Ferritinophagy by Regulating the NCOA4/FTH1/LC3 Pathway in Hepatocellular Carcinoma. Frontiers in pharmacology 77 35899120
2013 Iron deposition and ferritin heavy chain (Fth) localization in rodent teeth. BMC research notes 75 23281703
2022 FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis. Pharmaceuticals (Basel, Switzerland) 74 36297287
2024 CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis. Molecular cancer 66 38802795
2021 Ferroptosis Driver SOCS1 and Suppressor FTH1 Independently Correlate With M1 and M2 Macrophage Infiltration in Head and Neck Squamous Cell Carcinoma. Frontiers in cell and developmental biology 60 34527677
2022 Inhibition of cell survival and invasion by Tanshinone IIA via FTH1: A key therapeutic target and biomarker in head and neck squamous cell carcinoma. Experimental and therapeutic medicine 52 35837069
2020 FTH1 Pseudogenes in Cancer and Cell Metabolism. Cells 52 33260500
2023 M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma. Oncogene 51 38040806
2022 Clinical outcomes of unilateral biportal endoscopic lumbar interbody fusion (ULIF) compared with conventional posterior lumbar interbody fusion (PLIF). The spine journal : official journal of the North American Spine Society 47 36252809
2020 Estrogen-induced epigenetic silencing of FTH1 and TFRC genes reduces liver cancer cell growth and survival. Epigenetics 47 32476555
2021 A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis. International journal of molecular sciences 43 34445601
2023 Involvement of the JNK/HO‑1/FTH1 signaling pathway in nanoplastic‑induced inflammation and ferroptosis of BV2 microglia cells. International journal of molecular medicine 41 37264973
2024 METTL14 decreases FTH1 mRNA stability via m6A methylation to promote sorafenib-induced ferroptosis of cervical cancer. Cancer biology & therapy 40 38738555
2023 LncRNA CACNA1G-AS1 up-regulates FTH1 to inhibit ferroptosis and promote malignant phenotypes in ovarian cancer cells. Oncology research 39 37304234
2021 Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c-MYC. FEBS open bio 38 34551213
2014 MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice. British journal of haematology 31 24750026
2024 Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis. Cell death & disease 30 38740757
2024 CRYAB suppresses ferroptosis and promotes osteogenic differentiation of human bone marrow stem cells via binding and stabilizing FTH1. Aging 30 38787373
2024 Melatonin improves stroke by inhibiting autophagy-dependent ferroptosis mediated by NCOA4 binding to FTH1. Experimental neurology 30 38901754
2011 FTH1 binds to Daxx and inhibits Daxx-mediated cell apoptosis. Molecular biology reports 30 21573799
2020 FtH-Mediated ROS Dysregulation Promotes CXCL12/CXCR4 Axis Activation and EMT-Like Trans-Differentiation in Erythroleukemia K562 Cells. Frontiers in oncology 28 32432042
2022 HMOX1 Promotes Ferroptosis in Mammary Epithelial Cells via FTH1 and Is Involved in the Development of Clinical Mastitis in Dairy Cows. Antioxidants (Basel, Switzerland) 27 36421410
2025 Dual ferroptosis induction in N2-TANs and TNBC cells via FTH1 targeting: A therapeutic strategy for triple-negative breast cancer. Cell reports. Medicine 26 39809268
2023 Resveratrol attenuated high intensity exercise training-induced inflammation and ferroptosis via Nrf2/FTH1/GPX4 pathway in intestine of mice. Turkish journal of medical sciences 23 37476875
2024 Lipocalin-2 promotes CKD vascular calcification by aggravating VSMCs ferroptosis through NCOA4/FTH1-mediated ferritinophagy. Cell death & disease 21 39613734
2022 TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis. Oxidative medicine and cellular longevity 20 36164395
2021 Uncovering the Metabolic and Stress Responses of Human Embryonic Stem Cells to FTH1 Gene Silencing. Cells 20 34572080
2020 Iron Chelation Properties of Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Analysis on Tfr/Fth Regulations and Molecular Docking. Evidence-based complementary and alternative medicine : eCAM 20 32280356
2016 PLIF: A rapid, accurate method to detect and quantitatively assess protein-lipid interactions. Science signaling 20 27025878
2024 Baicalin induces ferroptosis in oral squamous cell carcinoma by suppressing the activity of FTH1. The journal of gene medicine 19 38380717
2023 A Disintegrin and Metalloproteinase-8 Protects Against Erastin-Induced Neuronal Ferroptosis via Activating Nrf2/HO-1/FTH1 Signaling Pathway. Molecular neurobiology 19 37995078
2019 Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms. PloS one 19 31491006
2002 PLIF, a novel human ferritin subunit from placenta with immunosuppressive activity. The Journal of biological chemistry 19 11821435
2025 Autophagy induced by mechanical stress sensitizes cells to ferroptosis by NCOA4-FTH1 axis. Autophagy 18 39988734
2022 Neurofilament Light Chain (NF-L) Stimulates Lipid Peroxidation to Neuronal Membrane through Microglia-Derived Ferritin Heavy Chain (FTH) Secretion. Oxidative medicine and cellular longevity 18 35368870
2016 Identification of human ferritin, heavy polypeptide 1 (FTH1) and yeast RGI1 (YER067W) as pro-survival sequences that counteract the effects of Bax and copper in Saccharomyces cerevisiae. Experimental cell research 18 26886577
2024 Blue light induced ferroptosis via STAT3/GPX4/SLC7A11/FTH1 in conjunctiva epithelium in vivo and in vitro. Journal of photochemistry and photobiology. B, Biology 17 38663336
2023 Heterozygous nonsense variants in the ferritin heavy-chain gene FTH1 cause a neuroferritinopathy. HGG advances 17 37660254
2022 A Comparative Study of a New Retractor-Assisted WILTSE TLIF, MIS-TLIF, and Traditional PLIF for Treatment of Single-Level Lumbar Degenerative Diseases. Orthopaedic surgery 17 35603557
2024 Liraglutide and GLP-1(9-37) alleviated hepatic ischemia-reperfusion injury by inhibiting ferroptosis via GSK3β/Nrf2 pathway and SMAD159/Hepcidin/FTH pathway. Redox biology 16 39693850
2023 NSUN5-FTH1 Axis Inhibits Ferroptosis to Promote the Growth of Gastric Cancer Cells. Cell biochemistry and biophysics 15 37528314
2023 AKT1 participates in ferroptosis vulnerability by driving autophagic degradation of FTH1 in cisplatin-resistant ovarian cancer. Biochemistry and cell biology = Biochimie et biologie cellulaire 14 37011414
2000 The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13. Gene 14 11167010
2024 Modulation of the HIF-1α-NCOA4-FTH1 Signaling Axis Regulating Ferroptosis-induced Hepatic Stellate Cell Senescence to Explore the Anti-hepatic Fibrosis Mechanism of Curcumol. Current medicinal chemistry 13 38351696
2024 Nanoparticles targeting OPN loaded with BY1 inhibits vascular restenosis by inducing FTH1-dependent ferroptosis in vascular smooth muscle cells. Biomaterials 13 38759485
2023 Myeloid FTH1 Deficiency Protects Mice From Colitis and Colitis-associated Colorectal Cancer via Reducing DMT1-Imported Iron and STAT3 Activation. Inflammatory bowel diseases 13 36745026
2023 miR-29a-5p modulates ferroptosis by targeting ferritin heavy chain FTH1 in prostate cancer. Biochemical and biophysical research communications 13 36806086
2023 RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability. Carcinogenesis 13 36913375
2011 The use of highly expressed FTH1 as carrier protein for cytosolic targeting in Hansenula polymorpha. Journal of biotechnology 13 22212821
2018 In Vitro Neural Differentiation of Bone Marrow Mesenchymal Stem Cells Carrying the FTH1 Reporter Gene and Detection with MRI. BioMed research international 12 30046590
2023 Heme Oxygenase-1-Modified BMMSCs Activate AMPK-Nrf2-FTH1 to Reduce Severe Steatotic Liver Ischemia-Reperfusion Injury. Digestive diseases and sciences 11 37707747
2016 Efficient expression of recombinant human heavy chain ferritin (FTH1) with modified peptides. Protein expression and purification 11 28013085
2025 High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancy. BMC pregnancy and childbirth 10 39789492
2003 PLIF induces IL-10 production in monocytes: a calmodulin-p38 mitogen-activated protein kinase-dependent pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 10 12670872
2024 Comparing the osteogenesis outcomes of different lumbar interbody fusions (A/O/X/T/PLIF) by evaluating their mechano-driven fusion processes. Computers in biology and medicine 9 38422963
2024 FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation. BMC musculoskeletal disorders 9 38609896
2024 Dual mTOR1/2 Inhibitor Sapanisertib (FTH-003/TAK-228) in Combination With Weekly Paclitaxel in Patients With Previously Treated Metastatic Urothelial Carcinoma: A Phase II Open-Label Study. Clinical genitourinary cancer 9 38905731
2022 TNFα-induced abnormal activation of TNFR/NF-κB/FTH1 in endometrium is involved in the pathogenesis of early spontaneous abortion. Journal of cellular and molecular medicine 9 35441429
2018 Annexin A2 and FTH1 are potential biomarkers for lupus nephritis. Experimental and therapeutic medicine 9 30344652
2017 A Comparative QSAR Analysis, Molecular Docking and PLIF Studies of Some N-arylphenyl-2, 2-Dichloroacetamide Analogues as Anticancer Agents. Iranian journal of pharmaceutical research : IJPR 9 29535790
2025 SMURF1-Induced Ubiquitination of FTH1 Disrupts Iron Homeostasis and Suppresses Myogenesis. International journal of molecular sciences 8 39941157
2025 Dimethyl malonate preserves brain and neurobehavioral phenotype following neonatal hypoxia-ischemia by inhibiting FTH1-mediated ferritinophagy. Redox biology 8 40749519
2024 The regulatory role of miR-21 in ferroptosis by targeting FTH1 and the contribution of microglia-derived miR-21 in exosomes to arsenic-induced neuronal ferroptosis. Journal of hazardous materials 8 39186845
2024 Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells. Experimental & molecular medicine 8 39294443
2020 Knockdown of ferritin heavy chain (FTH) inhibits the migration of prostate cancer through reducing S100A4, S100A2, and S100P expression. Translational cancer research 8 35117907
2011 Molecular cloning and copy number variation of a ferritin subunit (Fth1) and its association with growth in freshwater pearl mussel Hyriopsis cumingii. PloS one 8 21818403
2009 [Expression of FTL and FTH genes encoding ferretin subunits in lung and renal carcinomas]. Molekuliarnaia biologiia 8 20088381
2025 SH3GL1-activated FTH1 inhibits ferroptosis and confers doxorubicin resistance in diffuse large B-cell lymphoma. Clinical and translational medicine 7 40038872
2024 Phillyrin sensitizes lung cancer cells to ferroptosis through inhibiting FTH1/SLC7A11 axis. International journal of clinical pharmacology and therapeutics 7 37942927
2024 Dysregulation of Iron Homeostasis Mediated by FTH Increases Ferroptosis Sensitivity in TP53-Mutant Glioblastoma. Neuroscience bulletin 7 39666195
2024 Scutellaria barbata D.Don and Hedyotis diffusa Willd herb pair combined with cisplatin synergistically inhibits ovarian cancer progression through modulating oxidative stress via NRF2-FTH1 autophagic degradation pathway. Journal of ovarian research 7 39702302
2022 C-reactive protein to albumin ratio (CAR) in predicting surgical site infection (SSI) following instrumented posterior lumbar interbody fusion (PLIF). International wound journal 7 35579095
2022 SARS-CoV-2-induced hypomethylation of the ferritin heavy chain (FTH1) gene underlies serum hyperferritinemia in severe COVID-19 patients. Biochemical and biophysical research communications 7 36183555
2019 MRI Tracking of SPIO- and Fth1-Labeled Bone Marrow Mesenchymal Stromal Cell Transplantation for Treatment of Stroke. Contrast media & molecular imaging 7 31531004
2025 Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1. Free radical biology & medicine 6 39848345
2025 Endogenous Iron(II) Self-Enriched Fenton Nanocatalyst via FTH1 Activity Inhibition and Iron(III) Reduction for Amplified Cancer Ferroptosis Therapy. Molecular pharmaceutics 6 39913662
2025 Investigation of Ferroptosis Mechanisms in Ischemic Stroke Treated with Electroacupuncture: Focusing on the NCOA4-FTH1 Signaling Pathway. Neurochemical research 6 40189641
2025 Overcoming BET-inhibitor JQ1 resistance in aggressive non-small cell lung cancer by inducing ferroptosis via inhibition of the BRD2-FTH1 axis. The FEBS journal 6 40652527
2024 MiR-339-5p Inhibits Ferroptosis by Promoting Autophagic Degradation of FTH1 Through Targeting ATG7 in Liver Cancer Cells. Clinical Medicine Insights. Oncology 6 38628842
2024 Alantolactone facilitates ferroptosis in non-small cell lung cancer through promoting FTH1 ubiquitination and degradation. Chemical biology & drug design 6 39175059
2024 Carvedilol Confers Ferroptosis Resistance in HL-1 Cells by Upregulating GPX4, FTH1, and FTL1 and Inducing Metabolic Remodeling Under Hypoxia/Reoxygenation. Antioxidants (Basel, Switzerland) 6 39857341
2023 PTPRC Inhibits Ferroptosis of Osteosarcoma Cells via Blocking TFEB/FTH1 Signaling. Molecular biotechnology 6 37851191
2023 Carbonic Anhydrase Inhibitors Induce Ferroptosis through Inhibition of AKT/FTH1 Signaling in Ewing Sarcoma Tumor Cells. Cancers 6 37958399
2023 Autophagy mediated FTH1 degradation activates gasdermin E dependent pyroptosis contributing to diquat induced kidney injury. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 6 38128689
2025 OTULIN orchestrates NCOA4-FTH1 complex to alleviate APAP-induced hepatocyte Ferroptosis. International immunopharmacology 5 40158433
2025 Alkbh5 promotes Ythdf1 expression through demethylation thereby facilitating Fth1 translation to inhibit ferroptosis of myocardial infarction. BMC cardiovascular disorders 5 40251485
2025 Suppressing ferroptosis via modulating FTH1 by silybin for treatment of renal fibrosis. Phytomedicine : international journal of phytotherapy and phytopharmacology 5 40541121
2025 Sodium butyrate induces ferroptosis in colorectal cancer cells by promoting NCOA4-FTH1-mediated ferritinophagy. International immunopharmacology 5 40652583
2024 Association of FTH1-Expressing Circulating Tumor Cells With Efficacy of Neoadjuvant Chemotherapy for Patients With Breast Cancer: A Prospective Cohort Study. The oncologist 5 37390841
2017 FTH1 expression is affected by promoter polymorphism and not DNA methylation in response to DHV-1 challenge in duck. Developmental and comparative immunology 5 29051032

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