Affinage

DAXX

Death domain-associated protein 6 · UniProt Q9UER7

Length
740 aa
Mass
81.4 kDa
Annotated
2026-04-28
100 papers in source corpus 58 papers cited in narrative 58 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DAXX is a multifunctional scaffold protein that operates as a histone H3.3-specific chaperone within the ATRX-DAXX complex to deposit H3.3 at heterochromatic loci—telomeres, pericentromeres, and endogenous retroviruses (ERVs)—while also recruiting histone methyltransferases to catalyze de novo H3K9me3 on pre-deposition H3.3-H4, thereby establishing heterochromatin independently of DNA replication (PMID:29084956, PMID:36868228, PMID:26340527). Through two SUMO-interacting motifs whose selectivity is tuned by CK2 phosphorylation, DAXX reads SUMO modifications on transcription factors (including AR, GR, Smad4, SREBPs, and NF-κB p65) to recruit HDAC- and DNMT1-containing repressor complexes, functioning as a broad transcriptional corepressor that is itself sequestered and regulated by SUMO-1-modified PML at nuclear bodies (PMID:21474068, PMID:15572661, PMID:10669754, PMID:37045819). DAXX bridges MDM2 to the deubiquitinase HAUSP to stabilize MDM2 and promote p53 degradation under basal conditions; ATM-mediated phosphorylation at Ser564 upon DNA damage disrupts this ternary complex, triggering MDM2 self-degradation and p53 activation (PMID:16845383, PMID:23405218). DAXX also possesses an ATP-independent protein-folding/disaggregase activity dependent on its polyD/E region, capable of preventing and reversing aggregation of client proteins including p53 and MDM2, and this same domain is required for restriction of viral replication by SARS-CoV-2 and retroviruses (PMID:34408321, PMID:35508460).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1997 High

    The discovery that DAXX binds the Fas death domain and activates a JNK-dependent apoptotic pathway distinct from FADD established DAXX as a novel apoptotic signaling adaptor, resolving how Fas engagement could activate stress kinases independently of caspase-8.

    Evidence Protein-protein interaction mapping, overexpression, and dominant-negative inhibition in mammalian cells

    PMID:9215629

    Open questions at the time
    • Physiological relevance of DAXX-Fas binding debated in subsequent literature
    • Whether endogenous DAXX levels are sufficient to drive this pathway was unresolved
  2. 1998 High

    Identification of ASK1 as the kinase kinase activated by DAXX downstream of Fas explained the mechanism by which DAXX triggers JNK signaling—DAXX relieves an autoinhibitory interaction within ASK1.

    Evidence Co-immunoprecipitation, in vitro kinase assays, and dominant-negative ASK1 in Fas-stimulated cells

    PMID:9743501

    Open questions at the time
    • How DAXX is released from the nucleus to the cytoplasm upon Fas ligation was unclear
    • Whether ASK1 activation by DAXX occurs in all cell types was untested
  3. 1999 High

    The finding that PML recruits DAXX to nuclear bodies in a SUMO-1-dependent manner, and that Daxx knockout mice die with excessive apoptosis, reframed DAXX as having dual pro- and anti-apoptotic roles depending on subcellular context, and established SUMO-dependent regulation as central to DAXX biology.

    Evidence PML-null cell lines with rescue, immunofluorescence, and Daxx KO mouse embryonic lethality with TUNEL staining

    PMID:10444590 PMID:10525530

    Open questions at the time
    • The specific anti-apoptotic mechanism in vivo was undefined
    • Whether DAXX chromatin association outside PML bodies had functional significance was unknown
  4. 2000 High

    Demonstration that DAXX recruits HDACs to repress transcription and that PML-mediated sequestration relieves this repression established DAXX as a transcriptional corepressor regulated by PML nuclear body dynamics.

    Evidence Reporter gene assays, yeast two-hybrid, biochemical fractionation, and HSP27 phosphorylation mutant studies

    PMID:10669754 PMID:11003656

    Open questions at the time
    • Which endogenous target genes are directly repressed by DAXX was unknown
    • The chromatin-level mechanism of DAXX-mediated repression was uncharacterized
  5. 2003 High

    Discovery that ATRX and DAXX form a chromatin-remodeling complex with ATP-dependent activities distinct from SWI/SNF or NuRD defined the ATRX-DAXX complex as a novel chromatin remodeler, while RNAi depletion confirmed endogenous DAXX represses NF-κB/E2F1 targets and is anti-apoptotic.

    Evidence Co-immunoprecipitation, gel filtration, in vitro chromatin remodeling assay, RNAi with Bcl-2 rescue and reporter assays

    PMID:12482920 PMID:12953102

    Open questions at the time
    • The specific histone variant deposited by the ATRX-DAXX complex was unknown
    • Genomic targets of the complex were uncharacterized
  6. 2006 High

    The finding that DAXX bridges MDM2 to HAUSP, stabilizing MDM2 and promoting p53 degradation, with DNA-damage-induced dissociation leading to MDM2 self-destruction and p53 activation, placed DAXX at the hub of the p53-MDM2 regulatory axis.

    Evidence Co-immunoprecipitation, RNAi, ubiquitination assays, and DNA damage treatment

    PMID:16845383

    Open questions at the time
    • The specific damage-induced signal causing DAXX-MDM2 dissociation was unidentified
    • Whether DAXX chaperone activity contributes to MDM2/p53 regulation was unknown
  7. 2006 High

    Recognition that CK2-phosphorylated SUMO-interacting motifs in DAXX mediate selective SUMO-1 binding and that DAXX functions as a general SUMO reader for sumoylated transcription factors (AR, GR, Smad4, CBP) unified DAXX's diverse transcriptional repression activities under a single molecular mechanism.

    Evidence Reporter assays, NMR structural characterization of SIM-SUMO binding, CK2 phosphorylation assays, site-directed mutagenesis

    PMID:18031230 PMID:21383010 PMID:21474068

    Open questions at the time
    • How SUMO-paralog selectivity shapes DAXX target gene specificity genome-wide was unclear
    • Whether both SIMs function simultaneously in vivo was untested
  8. 2011 High

    The discovery that ATRX/DAXX mutations in pancreatic neuroendocrine tumors correlate with alternative lengthening of telomeres (ALT) established a causal link between DAXX loss, telomere maintenance dysfunction, and tumorigenesis.

    Evidence Exome sequencing of tumor cohorts, immunohistochemistry for protein loss, telomere FISH for ALT phenotype

    PMID:21719641

    Open questions at the time
    • Whether DAXX loss is sufficient for ALT initiation or requires cooperating mutations was unresolved
    • The precise molecular mechanism connecting DAXX loss to ALT was unknown
  9. 2012 High

    Showing that DAXX promotes H3.3 loading at activity-dependent genes in neurons upon calcineurin-mediated dephosphorylation, and at centromeric/pericentromeric heterochromatin, established DAXX as a signal-regulated, locus-specific H3.3 chaperone functioning beyond PML bodies.

    Evidence ChIP for H3.3, FRAP, calcineurin inhibitor treatment, DAXX KO in neurons, heat shock localization studies

    PMID:22500635 PMID:22572957

    Open questions at the time
    • Whether ATRX was required for all DAXX-mediated H3.3 deposition was unknown
    • The mechanism by which calcineurin dephosphorylation activates DAXX chaperone activity was uncharacterized
  10. 2013 Medium

    Identification of ATM-mediated Ser564 phosphorylation as the damage-induced signal that disrupts the DAXX-MDM2 interaction completed the signaling circuit linking DNA damage sensing to p53 activation through DAXX.

    Evidence Phospho-specific antibodies, Ser564Ala mutagenesis, ATM inhibitor, co-immunoprecipitation and p53 activation assays

    PMID:23405218

    Open questions at the time
    • Whether other kinases phosphorylate DAXX at Ser564 under different stress conditions was untested
    • Single-lab finding without independent replication at time of publication
  11. 2015 High

    Genome-wide ChIP-seq demonstrated that DAXX/ATRX is enriched at tandem repeats and ERVs in DNA-hypomethylated ESCs, mediating Suv39h-dependent H3K9me3 silencing, thus explaining how DAXX protects genome integrity at repetitive elements.

    Evidence ChIP-seq, RNA-seq, knockdown in hypomethylated mouse ESCs

    PMID:26340527

    Open questions at the time
    • Whether DAXX directly recruits Suv39h or whether H3.3 deposition is a prerequisite was unclear
    • Contribution of DAXX-only (ATRX-independent) complexes at these sites was unresolved
  12. 2017 High

    Crystal structure of the ATRX-DAXX interface combined with separation-of-function mutants revealed that DAXX represses ERVs through a biochemically distinct DAXX-SETDB1-KAP1-HDAC1 complex independently of ATRX and H3.3 deposition, demonstrating DAXX has ATRX-independent chromatin-repressive functions.

    Evidence X-ray crystallography, point mutagenesis abrogating ATRX binding, RNA-seq, co-immunoprecipitation defining DAXX-SETDB1-KAP1-HDAC1 complex

    PMID:29084956

    Open questions at the time
    • Whether the DAXX-SETDB1-KAP1-HDAC1 complex has genome-wide targets beyond ERVs was unknown
    • How cells partition DAXX between the two complexes was uncharacterized
  13. 2021 High

    The discovery that DAXX possesses intrinsic ATP-independent chaperone/disaggregase activity dependent on its polyD/E region—capable of preventing and reversing aggregation of p53, MDM2, and neurodegeneration-associated proteins—revealed a fundamentally new molecular activity for DAXX beyond histone chaperoning.

    Evidence In vitro aggregation and disaggregation assays with purified proteins, polyD/E domain deletion mutagenesis, functional restoration of aggregation-prone p53 mutants

    PMID:34408321

    Open questions at the time
    • Whether disaggregase activity operates on endogenous substrates in vivo was undemonstrated
    • Structural basis for how the polyD/E region mediates unfolding was unknown
    • Relative contribution of chaperone vs. histone deposition activity to tumor suppression was unclear
  14. 2023 High

    Demonstrating that DAXX recruits histone methyltransferases to catalyze H3K9me3 on soluble H3.3-H4 before deposition provided a molecular mechanism for de novo heterochromatin establishment, explaining how new histone marks are written prior to chromatin incorporation.

    Evidence Interactomics, co-chaperone complex characterization, in vitro H3K9me3 methylation assay on H3.3-H4, ChIP validation

    PMID:36868228

    Open questions at the time
    • Whether pre-deposition methylation is the dominant pathway for maintaining heterochromatin at all DAXX targets was unresolved
    • How DAXX coordinates pre-modification timing with deposition is mechanistically unclear
  15. 2023 Medium

    Identification of DAXX as a SUMO-dependent coactivator of SREBP1/2-mediated lipogenesis extended DAXX's transcriptional regulatory repertoire beyond repression, showing that DAXX-SUMO interactions can drive gene activation in a context-dependent manner.

    Evidence Co-immunoprecipitation, ChIP at lipogenic promoters, SIM2 mutants, cell-permeable peptide competition, xenograft tumor growth inhibition

    PMID:37045819

    Open questions at the time
    • Whether DAXX coactivation of SREBPs involves HDAC displacement or a distinct mechanism was unclear
    • Single-lab study; independent replication pending
    • Genome-wide scope of DAXX coactivation vs. corepression was undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: how DAXX partitions between its ATRX-dependent and ATRX-independent complexes in different cell types; whether its disaggregase activity operates on endogenous substrates in vivo; the structural basis for polyD/E-mediated protein unfolding; and what determines whether DAXX acts as a transcriptional corepressor versus coactivator at specific loci.
  • No structural model of full-length DAXX exists
  • In vivo clients of disaggregase activity are unidentified
  • Rules governing corepressor-to-coactivator switching are unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 7 GO:0042393 histone binding 5 GO:0060090 molecular adaptor activity 3 GO:0044183 protein folding chaperone 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005634 nucleus 4 GO:0005694 chromosome 3 GO:0005829 cytosol 3
Pathway
R-HSA-4839726 Chromatin organization 6 R-HSA-74160 Gene expression (Transcription) 6 R-HSA-5357801 Programmed Cell Death 5 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 3 R-HSA-73894 DNA Repair 3
Partners
ASK1ATRXHAUSPHDAC1MDM2MORC3PMLSETDB1
Complex memberships
ATRX-DAXXDAXX-SETDB1-KAP1-HDAC1MDM2-DAXX-HAUSP

Evidence

Reading pass · 58 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 DAXX was identified as a novel protein that binds specifically to the Fas death domain via its C-terminal portion, and a different region activates both JNK and apoptosis. Overexpression of DAXX enhances Fas-mediated apoptosis and activates the JNK pathway, defining a signaling pathway distinct from FADD. Protein-protein interaction (binding assay), overexpression, dominant-negative inhibition Cell High 9215629
1998 DAXX activates the JNK kinase kinase ASK1 upon Fas stimulation; Fas activation induces DAXX to interact with ASK1, which relieves an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity. Co-immunoprecipitation, kinase assay, dominant-negative ASK1 overexpression Science High 9743501
1999 PML is essential for DAXX recruitment to nuclear domain 10 (ND10/PML nuclear bodies); in the absence of PML, DAXX localizes to condensed chromatin. SUMO-1 modification of PML is required for recruitment of DAXX from condensed chromatin to ND10, mediated by interaction between the C-terminal domain of DAXX and PML. Immunofluorescence, co-immunoprecipitation, PML-null cell lines, transient PML expression rescue The Journal of cell biology High 10525530
1999 Daxx-deficient mice die early in embryogenesis with extensive apoptosis, demonstrating that Daxx functions in an anti-apoptotic capacity in vivo rather than solely as a pro-apoptotic factor. Gene knockout (mouse), TUNEL staining, embryonic lethality phenotype Genes & development High 10444590
2000 DAXX functions as a transcriptional repressor that recruits histone deacetylases; PML sequesters DAXX to PML oncogenic domains (PODs) via SUMO-1-modified PML, inhibiting DAXX-mediated transcriptional repression. PML-RARalpha fusion does not inhibit DAXX repression. Reporter gene assay, immunofluorescence, yeast two-hybrid, biochemical fractionation Molecular and cellular biology High 10669754
2000 Phosphorylated dimers of HSP27 interact with DAXX, preventing DAXX interaction with both ASK1 and Fas, and blocking Daxx-mediated apoptosis. HSP27 also blocks Fas-induced translocation of DAXX from the nucleus to the cytoplasm. Co-immunoprecipitation, dominant-negative and phosphorylation-mutant HSP27, apoptosis assays Molecular and cellular biology High 11003656
2000 DAXX interacts with ETS1 through its C-terminal 173 amino acid region; this interaction represses transcriptional activation of ETS1 target genes MMP1 and BCL2. The ETS1 interaction domain in DAXX is conserved in several other Daxx-interacting proteins. Yeast two-hybrid, in vitro binding, co-localization, reporter gene assay, domain mapping Oncogene Medium 10698492
2001 ASK1 controls the subcellular localization of DAXX: ASK1 sequesters DAXX in the cytoplasm, where DAXX is bound to activated Fas and mediates pro-apoptotic signaling. In the absence of ASK1, DAXX localizes to the nucleus and functions as a transcriptional repressor. Immunofluorescence, transcriptional reporter assay, co-immunoprecipitation The Journal of biological chemistry Medium 11495919
2003 ATRX forms a chromatin-remodeling complex with DAXX; the ATRX-DAXX complex displays ATP-dependent chromatin-remodeling activities including triple-helix DNA displacement and mononucleosome disruption, distinct from SWI/SNF or NURD complexes. Both proteins co-localize in PML nuclear bodies. Co-immunoprecipitation, gel filtration, ATP-dependent chromatin remodeling assay, immunofluorescence PNAS High 12953102
2003 RNAi-mediated depletion of endogenous DAXX in cell lines results in increased apoptosis (rescued by Bcl-2) and transcriptional derepression of NF-κB and E2F1 target genes, confirming DAXX has anti-apoptotic and transcriptional repressor functions. RNAi knockdown, apoptosis assay, Bcl-2 rescue, transcriptional reporter assay Journal of cell science High 12482920
2003 Phosphorylation of DAXX at Ser667 by the ASK1-SEK1-JNK1-HIPK1 pathway mediates DAXX relocalization from nucleus to cytoplasm during glucose deprivation. Cytoplasmic DAXX then binds to ASK1, promoting ASK1 oligomerization and JNK1 activation. In vivo phosphorylation labeling, immune complex kinase assay, immunofluorescence, site-directed mutagenesis The Journal of biological chemistry Medium 12968034
2004 DAXX binds to the C-terminal domain of p53 via its acidic domain; acetylation and phosphorylation of p53 regulate its interaction with DAXX. MDM2 expression restores DAXX-p53 interaction and correlates with p53 deacetylation. DAXX functions as a novel negative regulator of p53, suppressing p53-dependent apoptosis. Co-immunoprecipitation, GST pulldown, Lys-to-Ala mutagenesis, reporter assay, apoptosis rescue The Journal of biological chemistry Medium 15364927
2004 DAXX functions as a negative coregulator of androgen receptor (AR) through direct protein-protein interaction with both the AR amino-terminal domain and DNA-binding domain; DAXX interferes with AR DNA-binding activity. Sumoylation of AR is involved in DAXX interaction and trans-repression. Co-immunoprecipitation, in vitro binding, ChIP, reporter assay, RNAi knockdown, EMSA Molecular and cellular biology High 15572661
2005 DAXX is required for stress-induced cell death and JNK activation in primary fibroblasts. RNAi depletion of DAXX in primary fibroblasts renders cells resistant to UV- and oxidative stress-induced cell death and impairs MKK/JNK activation. RNAi knockdown, UV and oxidative stress apoptosis assays, JNK kinase assays in primary cells Cell death and differentiation Medium 15861194
2006 DAXX is required for MDM2 stability: DAXX simultaneously binds MDM2 and the deubiquitinase HAUSP/USP7, mediating the stabilizing effect of HAUSP on MDM2. DAXX enhances the intrinsic E3 ligase activity of MDM2 toward p53. Upon DNA damage, DAXX dissociates from MDM2, correlating with MDM2 self-degradation and p53 activation. Co-immunoprecipitation, RNAi knockdown, overexpression, ubiquitination assay, DNA damage treatment Nature cell biology High 16845383
2006 DAXX acts as a SUMO reader: SUMO modification of transcription factors (AR, GR, Smad4, CBP) recruits DAXX via its SUMO-interacting motif, causing transcriptional repression. SUMO-1-modified PML competes with SUMOylated transcription factors for DAXX binding, relieving DAXX-mediated repression. Reporter assay, co-immunoprecipitation, domain mapping, SUMO-interaction studies Biochemical Society transactions Medium 18031230
2006 DNA damage triggers DAXX ubiquitination and proteasomal degradation; this releases RASSF1C from PML nuclear bodies. The released RASSF1C translocates to cytoplasmic microtubules and activates SAPK/JNK, linking nuclear DNA damage to cytoplasmic kinase signaling. Co-immunoprecipitation, immunofluorescence, siRNA knockdown, ubiquitination assay, JNK activation assay The EMBO journal Medium 16810318
2006 Sumoylation of DAXX at K630/K631 is required for its nuclear localization and IFN-induced growth suppression of B lymphocytes; sumoylation-defective DAXX KA mutant localizes to the cytoplasm and fails to suppress growth. Nuclear localization via sumoylation is required for proper interaction with PML. Sumoylation-defective mutant expression, immunofluorescence, leptomycin B treatment, growth suppression assay Journal of immunology Medium 16818774
2007 DAXX represses c-met transcription by binding to the c-met promoter and recruiting HDAC2; Daxx-null mouse cells show elevated c-met, which is reversed by Daxx reconstitution. Chromatin acetylation changes at the c-met promoter are dependent on DAXX. ChIP, Daxx-knockout mouse cells, reconstitution, chromatin acetylation assay Oncogene Medium 17952115
2007 DAXX cooperates with the Axin/HIPK2/p53 complex to induce cell death: DAXX associates with Axin at endogenous levels (enhanced by UV); Axin tethers DAXX to p53 and cooperates with DAXX to stimulate HIPK2-mediated Ser46 phosphorylation and PUMA transcription. A DAXX mutant unable to interact with Axin fails to inhibit colony formation. Co-immunoprecipitation, UV irradiation, siRNA, HIPK2 kinase assay, colony formation Cancer research Medium 17210684
2007 DAXX represses NF-κB transcriptional activity by inhibiting p65 acetylation; DAXX physically interacts with the p65 subunit of NF-κB (induced by TNFα), and this interaction prevents p300/CBP-mediated acetylation of p65, suppressing NF-κB target gene expression. ChIP, EMSA, co-immunoprecipitation, reporter assay, acetylation assay Journal of molecular biology Medium 17362989
2009 CHIP (carboxyl terminus of Hsp70-interacting protein) interacts with DAXX in a stress-dependent manner, ubiquitinates DAXX at K630/K631 (competing with sumoylation), partitions DAXX to an insoluble compartment, and blocks HIPK2-DAXX interaction, thereby suppressing Ser46 phosphorylation of p53 and the p53-dependent apoptotic program. Co-immunoprecipitation, in vitro ubiquitination, microarray, dominant-negative and KO fibroblasts The Journal of biological chemistry Medium 19465479
2009 HCMV pp71 protein promotes the SUMOylation of DAXX; pp71 displaces ATRX from DAXX and mediates DAXX degradation through a ubiquitin-independent, proteasome-dependent mechanism to stimulate viral immediate-early gene expression. Co-immunoprecipitation, proteasome inhibitor treatment, overexpression, viral infection assay Journal of virology Medium 19369322
2009 DAXX directly represses C/EBPβ transcriptional activity; DAXX binds C/EBPβ via amino acids 190-400, decreases p300-mediated C/EBPβ acetylation, and suppresses basal and p300-enhanced C/EBPβ transcriptional activity. PML abrogates this repression by re-recruiting DAXX to PML-oncogenic domains. GST pulldown, co-immunoprecipitation, reporter assay, acetylation assay, immunofluorescence The Journal of biological chemistry Medium 19690170
2010 Adenovirus E1B-55K binds DAXX and induces its proteasome-dependent degradation, independently of E4orf6, to counteract DAXX-mediated restriction of adenoviral replication. DAXX knockdown increases adenoviral mRNA synthesis and protein expression. Co-immunoprecipitation, RNAi, proteasome inhibitor, viral replication assay Journal of virology Medium 20484509
2011 ATRX and DAXX mutations in pancreatic neuroendocrine tumors are associated with alternative lengthening of telomeres (ALT), indicating that the ATRX-DAXX complex participates in telomere chromatin remodeling and that its loss leads to a telomerase-independent telomere maintenance mechanism. Exome sequencing, immunohistochemistry for ATRX/DAXX loss, telomere FISH for ALT Science High 21719641
2011 The EBV tegument protein BNRF1 disrupts the DAXX-ATRX chromatin remodeling complex at PML nuclear bodies; BNRF1 interacts with DAXX and displaces ATRX, supporting viral early gene activation. Knockdown of DAXX or ATRX reactivates EBV from latency. Co-immunoprecipitation, immunofluorescence, RT-PCR, RNAi knockdown, viral infection assay PLoS pathogens Medium 22102817
2011 CK2 kinase phosphorylates DAXX at its SUMO-interacting motif (SIM) residues S737 and S739, promoting preferential binding to SUMO-1 over SUMO-2/3, causing DAXX preference for SUMO-1 conjugation and interaction with SUMO-1-modified factors. NMR structure shows DAXX-SIM binds SUMO-1 in a parallel orientation. Phosphorylation enhances DAXX sensitization to stress-induced apoptosis via antiapoptotic gene repression. NMR structure, phosphorylation assay, site-directed mutagenesis, reporter assay, apoptosis assay Molecular cell High 21474068
2011 DAXX mediates activation-induced cell death (AICD) in microglia by triggering MST1 homodimerization, activation, and nuclear translocation upon IFN-γ stimulation. IFN-γ upregulates DAXX expression, and DAXX or MST1 depletion attenuates IFN-γ-induced microglial apoptosis. RNAi knockdown, immunofluorescence, kinase activation assay, MST1-null mice, primary microglia The EMBO journal Medium 21572393
2011 NMR spectroscopy characterization of DAXX's two SUMO-interacting motifs (SIM-N and SIM-C): SIM-N binds SUMO-1 in a parallel orientation with ~4-fold higher affinity than SIM-C; SIM-N can bind intramolecularly to the adjacent N-terminal helical bundle, suggesting autoregulation. SIM-C mediates interaction with sumoylated ETS1 through SUMO-1. NMR spectroscopy, peptide binding assays, affinity measurements The Journal of biological chemistry High 21383010
2012 DAXX promotes H3.3 loading at regulatory regions of activity-dependent genes in neurons upon membrane depolarization; calcineurin-mediated dephosphorylation of DAXX is a key molecular switch controlling its function upon neuronal activation. DAXX loss impairs both H3.3 deposition and transcriptional induction of activity-regulated genes. ChIP, FRAP, calcineurin inhibitor treatment, DAXX KO/knockdown, neuronal activity assay Neuron High 22500635
2012 DAXX and ATRX are required to maintain a repressed chromatin environment at a CMV-promoter transgene array; ICP0 (HSV-1 E3 ubiquitin ligase) depletes DAXX and ATRX from the activated array. H3.3 is recruited but not incorporated into chromatin during activation, linking DAXX/ATRX to transcriptional repression and chromatin assembly. Single-cell live imaging, ChIP, RNAi, immunofluorescence with FISH, ATRX-null cell line Journal of cell science Medium 22976303
2012 DAXX interacts with APC/C coactivators Cdc20 and Cdh1 (via D-box sequences near the N-terminal of DAXX), inhibits the degradation of APC/Cdc20 and APC/Cdh1 substrates, and causes a transient delay in mitotic progression. D-box deleted DAXX mutant loses this inhibitory activity. Co-immunoprecipitation, D-box mutant, APC/C substrate degradation assay, cell cycle analysis Carcinogenesis Medium 23239745
2012 DAXX localizes to centromeres/pericentromeres during heat shock, and its presence at these regions is required for H3.3 incorporation into centromeric/pericentromeric heterochromatin under normal conditions and protection of epigenetic modifications under stress. Immunofluorescence, DAXX depletion, ChIP for H3.3 and histone modifications Nucleus Medium 22572957
2013 ATM phosphorylates DAXX at Ser564 upon DNA damage; this phosphorylation disrupts the DAXX-MDM2 interaction, stabilizes p53, and facilitates p53 activation. Blockage of Ser564 phosphorylation prevents DAXX-MDM2 dissociation and inhibits DNA damage-induced p53 activation. Phosphorylation assay, site-directed mutagenesis (Ser564Ala), ATM inhibitor, co-immunoprecipitation, p53 activation assay PloS one Medium 23405218
2014 BNRF1 forms a ternary complex BNRF1-DAXX-H3.3-H4 (replacing ATRX), demonstrated by co-immunoprecipitation and size-exclusion chromatography with purified components. BNRF1 promotes global mobilization of H3.3 and suppresses DAXX-ATRX-mediated H3.3 loading on viral chromatin, generating chromatin permissive for EBV latent gene expression. Co-immunoprecipitation, size-exclusion chromatography with purified proteins, FRAP, ChIP, immunofluorescence FISH Journal of virology High 25275136
2014 Endogenous DAXX localizes to Cajal bodies, associates with telomerase, and regulates telomerase targeting to telomeres. DAXX knockdown reduces telomerase targeting to telomeres and leads to telomere shortening. Disease-associated DAXX mutations differentially affect interaction with binding partners and targeting to Cajal bodies. Co-immunoprecipitation, immunofluorescence, RNAi, telomere length analysis, disease mutant analysis Journal of cell science Medium 25416818
2014 DAXX selectively represses IL-6 transcription in macrophages by binding to the IL-6 promoter and recruiting HDAC1, mediating histone deacetylation. DAXX silencing decreases HDAC1 association with the IL-6 promoter. ChIP, siRNA knockdown, co-immunoprecipitation, reporter assay The Journal of biological chemistry Medium 24550390
2015 The DAXX/ATRX complex is co-enriched at tandem repetitive elements in mouse ESCs; global DNA hypomethylation promotes recruitment of the complex to tandem repeats including retrotransposons and telomeres. DAXX/ATRX-mediated repression involves Suv39h recruitment and H3K9 trimethylation to protect repeat elements from transcriptional de-repression. ChIP-seq, genome-wide binding analysis, RNA-seq, knockdown in hypomethylated cells Cell stem cell High 26340527
2015 In the absence of DAXX, H3K9me3-enriched heterochromatin domains are structurally altered and become uncoupled from major satellite DNA; nucleolar structure and rDNA organization are also disrupted. DAXX loss increases global chromatin sensitivity to MNase digestion. Electron spectroscopic imaging (ESI), MNase digestion, immunofluorescence, Daxx-null cells Epigenetics & chromatin Medium 26500702
2015 PML stabilizes cytoplasmic DAXX, and cytoplasmic DAXX inhibits reverse transcription of HIV-1 and other retroviruses; DAXX is found in the vicinity of incoming HIV-1 capsids and inhibits retroviral reverse-transcription and retrotransposition of endogenous retroviruses. PML/DAXX knockdown, reverse transcription quantitative assay, immunofluorescence, retrotransposition assay PLoS pathogens Medium 26566030
2015 DAXX represses autophagy modulators DAPK3 and ULK1 in prostate cancer cells, thereby suppressing autophagy and promoting tumorigenicity; DAXX knockdown increases autophagic flux. Stable RNAi knockdown, mouse xenograft, ChIP, autophagic flux assay The Journal of biological chemistry Medium 25903140
2016 Menin and DAXX directly interact to suppress neuroendocrine tumor cell proliferation by repressing membrane metallo-endopeptidase (MME) expression; this repression requires H3K9me3 at the MME promoter mediated partly by SUV39H1. The MEN1 T429K disease mutation reduces DAXX binding. Co-immunoprecipitation, ChIP, siRNA, xenograft, disease mutant analysis Cancer research Medium 27872097
2016 DAXX directly binds to the DNA-binding domain of Slug, impeding HDAC1 recruitment and antagonizing Slug E-box binding to suppress EMT and cancer invasion. Under hypoxia, HIF-1α downregulates DAXX expression, promoting cancer invasion. Co-immunoprecipitation, in vitro binding, HDAC1 recruitment assay, ChIP, EMT assay, orthotopic mouse model Nature communications Medium 28004751
2017 High-resolution X-ray crystal structure of the ATRX-DAXX interaction surface was determined. DAXX single amino acid substitutions that abrogate ATRX complex formation reveal that repression of specific endogenous retroviruses (ERVs) depends on DAXX but not ATRX. A biochemically distinct DAXX-SETDB1-KAP1-HDAC1 complex represses ERVs independently of ATRX and H3.3 incorporation. H3.3 stabilizes DAXX protein levels. X-ray crystallography, site-directed mutagenesis, biochemical fractionation, RNA-seq, co-immunoprecipitation Nature communications High 29084956
2017 PTEN interacts with DAXX and directly regulates oncogene expression by modulating DAXX-H3.3 association on chromatin, independently of PTEN enzymatic activity. DAXX inhibition suppresses tumor growth in PTEN-deficient glioma. Co-immunoprecipitation, ChIP, DAXX siRNA, orthotopic xenograft, H3.3 ChIP-seq Nature communications Medium 28497778
2017 CUL3-SPOP acts as an E3 ubiquitin ligase complex targeting DAXX for degradation; knockdown of SPOP and CUL3 leads to DAXX upregulation, which inversely correlates with VEGFR2, NOTCH1, DLL4, and NRP1 expression in endothelial cells. Simultaneous SPOP and DAXX knockdown reverses VEGFR2 downregulation. siRNA knockdown, protein expression analysis, epistasis knockdown experiment Scientific reports Medium 28216678
2019 SUMO-2/3 interacts directly with DAXX and regulates its subcellular localization; alteration of SUMO-2/3 expression leads to altered DAXX nuclear/cytoplasmic distribution. Cytoplasmic DAXX inhibits proliferation and promotes apoptosis while nuclear DAXX has opposing effects in gastric cancer. Co-immunoprecipitation, immunofluorescence, SUMO-2/3 knockdown, cell biology assays Cell death & disease Medium 32641734
2019 Acetylation of SUMO1 at K37, K39, or K46 reduces SUMO1 binding to the phosphorylated SIMs of PML and DAXX; X-ray crystal structures of acetylated SUMO1 variants bound to phosphoSIMs reveal structural plasticity providing a regulatory mechanism for SUMO-SIM interactions in PML nuclear bodies. X-ray crystallography, binding assays, acetylation mimetic mutants Structure High 31879127
2019 DAXX-mediated repression of stem/pluripotent genes (NOTCH4, SOX2, OCT4, NANOG, ALDH1A1) in ER+ breast cancer is dependent on DNMT1; estradiol-mediated ER activation stabilizes DAXX protein, which is enriched at promoters of these genes and recruits DNMT1 for methylation. Endocrine therapy promotes DAXX degradation via increased proteasome activity. ChIP, DNMT1/DAXX knockdown, DNA methylation bisulfite sequencing, proteasome inhibitor Cancer research Medium 31387918
2020 ATRX affects telomeric double-strand break repair by promoting sister telomere cohesion and through a DAXX-dependent pathway. Loss of telomeric cohesion combined with DAXX deficiency recapitulates all telomeric DSB repair phenotypes associated with ATRX loss, including ALT-associated PML bodies and T-SCEs. ATRX/DAXX deletion, telomere sister chromatid exchange assay, ALT-associated PML body analysis, cohesion assay PLoS biology Medium 31895940
2020 Morc3 ATPase interacts with DAXX via Morc3 SUMOylation and Daxx SUMO binding; Morc3 knockout cells show reduced DAXX-mediated H3.3 incorporation at ERV regions and ERV de-repression. Morc3 mutant proteins that fail to interact with DAXX also fail to maintain ERV silencing. sgRNA screen, proteomics, Morc3 KO, H3.3 ChIP, SUMO-binding mutagenesis Nature communications Medium 34650047
2020 Daxx loss in mouse pancreatic cells creates a permissive transcriptional state associated with dysregulation of endogenous retroviral elements (ERVs) and cooperates with inflammation and Men1 loss to alter cell state. DAXX-regulated ERV silencing is linked to its H3.3 chaperone function. Conditional mouse KO, RNA-seq, ERV analysis, inflammatory stress model, Men1 double KO Science advances Medium 32821827
2021 DAXX prevents protein aggregation, solubilizes pre-existing aggregates, and unfolds misfolded species of model substrates and neurodegeneration-associated proteins (including p53 and MDM2) in an ATP-independent manner relying on its polyD/E region; DAXX can restore native conformation and function to aggregation-prone p53 cancer mutants. In vitro aggregation assay, disaggregation/unfolding assay, polyD/E domain mutagenesis, p53 functional restoration assay Nature High 34408321
2022 DAXX and ATRX knockout cells show genome-wide reduction in p53 chromatin binding, loss of chromatin accessibility at p53 response elements (ChIP-seq and ATAC-seq), and depletion of H3.3 with accumulation of γH2AX at many p53 sites including subtelomeres, linking DAXX/ATRX histone chaperone function to p53 DNA damage response. DAXX/ATRX KO, ChIP-seq, ATAC-seq, RNA-seq, γH2AX assay Nature communications Medium 36028493
2022 DAXX restricts an early, post-entry step of SARS-CoV-2 replication independently of SUMOylation but dependently on its D/E (polyD/E) domain, which is necessary for its protein-folding activity. SARS-CoV-2 PLpro (papain-like protease) promotes DAXX re-localization to cytoplasmic sites and proteasomal degradation. CRISPR/Cas9 screen, overexpression, domain deletion mutants, proteasome inhibitor, viral replication assay Nature communications Medium 35508460
2023 DAXX provides a unique function in the histone chaperone network by recruiting histone methyltransferases to promote H3K9me3 catalysis on new H3.3-H4 prior to deposition onto DNA, providing a molecular mechanism for de novo H3K9me3 deposition and heterochromatin assembly. Exploratory interactomics, co-chaperone complex characterization, H3K9me3 methylation assay on H3.3-H4, ChIP Molecular cell High 36868228
2023 DAXX interacts with SREBP1 and SREBP2 transcription factors via its SUMO-binding activity (SIM2); DAXX associates with lipogenic gene promoters through SREBPs to activate SREBP-mediated transcription and lipogenesis. A cell-permeable DAXX SIM2 peptide disrupts DAXX-SREBP1/2 interactions and inhibits lipogenesis and tumor growth. Co-immunoprecipitation, ChIP, SREBP2 knockdown, DAXX/SIM mutants, lipogenesis assay, xenograft, peptide competition Nature communications Medium 37045819

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (New York, N.Y.) 1389 21252315
2011 Altered telomeres in tumors with ATRX and DAXX mutations. Science (New York, N.Y.) 871 21719641
1997 Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 813 9215629
1999 PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. The Journal of cell biology 708 10525530
1998 Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science (New York, N.Y.) 521 9743501
2000 Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Molecular and cellular biology 351 11003656
2000 Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. Molecular and cellular biology 310 10669754
2003 The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies. Proceedings of the National Academy of Sciences of the United States of America 304 12953102
1999 Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development. Genes & development 208 10444590
2006 Critical role for Daxx in regulating Mdm2. Nature cell biology 195 16845383
2018 ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup. Nature communications 172 30315258
2000 EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. Oncogene 157 10698492
2006 Daxx: death or survival protein? Trends in cell biology 153 16406523
2011 Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation. Molecular cell 140 21474068
2015 The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation. Cell stem cell 118 26340527
2011 EBV tegument protein BNRF1 disrupts DAXX-ATRX to activate viral early gene transcription. PLoS pathogens 116 22102817
2003 RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX. Journal of cell science 114 12482920
2010 Proteasome-dependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells. Journal of virology 111 20484509
2017 PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nature communications 109 28497778
2019 DAXX in cancer: phenomena, processes, mechanisms and regulation. Nucleic acids research 99 31350900
2004 Negative modulation of androgen receptor transcriptional activity by Daxx. Molecular and cellular biology 98 15572661
2001 Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm. The Journal of biological chemistry 98 11495919
2017 Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX. Nature communications 91 29084956
2007 Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death. Cancer research 85 17210684
2008 Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein. Journal of virology 80 18480450
2016 Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis. Nature communications 76 28004751
2012 Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. Neuron 76 22500635
2005 Daxx is required for stress-induced cell death and JNK activation. Cell death and differentiation 75 15861194
2003 Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization. The Journal of biological chemistry 75 12968034
2009 Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis. Virus research 73 19944121
2021 DAXX represents a new type of protein-folding enabler. Nature 72 34408321
2018 Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication. Journal of virology 59 29491153
2004 Negative regulation of p53 functions by Daxx and the involvement of MDM2. The Journal of biological chemistry 58 15364927
2006 Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. The EMBO journal 56 16810318
2000 The Daxx enigma. Apoptosis : an international journal on programmed cell death 55 11225842
2013 Death domain-associated protein DAXX promotes ovarian cancer development and chemoresistance. The Journal of biological chemistry 54 23539629
2020 ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity. PLoS biology 53 31895940
2007 Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization. Biochemical Society transactions 53 18031230
2023 DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network. Molecular cell 52 36868228
2014 Viral reprogramming of the Daxx histone H3.3 chaperone during early Epstein-Barr virus infection. Journal of virology 50 25275136
2015 PML/TRIM19-Dependent Inhibition of Retroviral Reverse-Transcription by Daxx. PLoS pathogens 49 26566030
2008 PML NBs (ND10) and Daxx: from nuclear structure to protein function. Frontiers in bioscience : a journal and virtual library 48 18508722
2007 Inhibition of NF-kappaB acetylation and its transcriptional activity by Daxx. Journal of molecular biology 47 17362989
2012 Single-cell analysis of Daxx and ATRX-dependent transcriptional repression. Journal of cell science 46 22976303
2018 HJURP antagonizes CENP-A mislocalization driven by the H3.3 chaperones HIRA and DAXX. PloS one 45 30365520
2011 Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. The EMBO journal 45 21572393
2022 Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen. Nature communications 44 35508460
2022 Tanshinone IIA inhibits cardiomyocyte apoptosis and rescues cardiac function during doxorubicin-induced cardiotoxicity by activating the DAXX/MEK/ERK1/2 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology 43 36182795
2009 Human cytomegalovirus protein pp71 induces Daxx SUMOylation. Journal of virology 43 19369322
2021 Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation. Nature communications 42 34650047
2000 Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9. Biochemical and biophysical research communications 42 11112409
2022 DAXX-ATRX regulation of p53 chromatin binding and DNA damage response. Nature communications 41 36028493
2012 Methylation of RASSF1A gene promoter is regulated by p53 and DAXX. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 41 23038753
2003 Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx. Journal of virology 41 14557665
2018 Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization. Nucleic acids research 40 30335163
2013 Virion factors that target Daxx to overcome intrinsic immunity. Journal of virology 40 23864634
2019 Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. Scientific reports 39 30872698
2016 Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase. Cancer research 38 27872097
2014 Clinical features of ATRX or DAXX mutated neuroblastoma. Journal of pediatric surgery 37 25487495
2012 Daxx regulates mitotic progression and prostate cancer predisposition. Carcinogenesis 37 23239745
2010 DJ-1 loss by glutaredoxin but not glutathione depletion triggers Daxx translocation and cell death. Antioxidants & redox signaling 37 20014998
2019 Targeting Telomerase and ATRX/DAXX Inducing Tumor Senescence and Apoptosis in the Malignant Glioma. International journal of molecular sciences 36 30625996
2007 Regulation of c-met expression by transcription repressor Daxx. Oncogene 36 17952115
2015 Transcriptional Repressor DAXX Promotes Prostate Cancer Tumorigenicity via Suppression of Autophagy. The Journal of biological chemistry 35 25903140
2012 Dualistic function of Daxx at centromeric and pericentromeric heterochromatin in normal and stress conditions. Nucleus (Austin, Tex.) 35 22572957
2006 Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells. The Journal of biological chemistry 35 16569639
2006 Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation. Journal of immunology (Baltimore, Md. : 1950) 35 16818774
2007 Myocardial expression of a dominant-negative form of Daxx decreases infarct size and attenuates apoptosis in an in vivo mouse model of ischemia/reperfusion injury. Circulation 33 18025529
2019 DAXX Suppresses Tumor-Initiating Cells in Estrogen Receptor-Positive Breast Cancer Following Endocrine Therapy. Cancer research 31 31387918
2020 Functional cross talk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery. Human molecular genetics 30 31628488
2020 Opposing biological functions of the cytoplasm and nucleus DAXX modified by SUMO-2/3 in gastric cancer. Cell death & disease 30 32641734
2011 Characterizing the N- and C-terminal Small ubiquitin-like modifier (SUMO)-interacting motifs of the scaffold protein DAXX. The Journal of biological chemistry 30 21383010
2018 Loss of ATRX/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas. Cancer 29 30423196
2011 Regulation of mitosis and taxane response by Daxx and Rassf1. Oncogene 29 21643015
2017 Variable DAXX gene methylation is a common feature of placental trophoblast differentiation, preeclampsia, and response to hypoxia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 28223336
2014 Death domain-associated protein 6 (Daxx) selectively represses IL-6 transcription through histone deacetylase 1 (HDAC1)-mediated histone deacetylation in macrophages. The Journal of biological chemistry 28 24550390
2009 Stress-dependent Daxx-CHIP interaction suppresses the p53 apoptotic program. The Journal of biological chemistry 27 19465479
2020 Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo. Science advances 26 32821827
2017 The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells. Scientific reports 26 28216678
2009 Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta. The Journal of biological chemistry 26 19690170
2015 The histone chaperone DAXX maintains the structural organization of heterochromatin domains. Epigenetics & chromatin 25 26500702
2014 Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance. Journal of cell science 25 25416818
2013 Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation. PloS one 25 23405218
2019 Hotspot DAXX, PTCH2 and CYFIP2 mutations in pancreatic neuroendocrine neoplasms. Endocrine-related cancer 24 30021865
2014 Distribution and location of Daxx in cervical epithelial cells with high risk human papillomavirus positive. Diagnostic pathology 24 24398161
2006 Physical and functional interactions between Daxx and STAT3. Oncogene 24 16331268
2003 Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation. Biochemical and biophysical research communications 24 14637155
2024 HIRA vs. DAXX: the two axes shaping the histone H3.3 landscape. Experimental & molecular medicine 23 38297159
2019 PML is recruited to heterochromatin during S phase and represses DAXX-mediated histone H3.3 chromatin assembly. Journal of cell science 22 30796101
2010 DAXX is a new AIRE-interacting protein. The Journal of biological chemistry 22 20185822
2019 Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure (London, England : 1993) 21 31879127
2005 Expression of a dominant negative form of Daxx in vivo rescues motoneurons from Fas (CD95)-induced cell death. Journal of neurobiology 21 15459896
2004 Physical and functional interactions between Daxx and TSG101. Biochemical and biophysical research communications 21 15033475
2023 DAXX drives de novo lipogenesis and contributes to tumorigenesis. Nature communications 20 37045819
2023 Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in non-functional pancreatic neuroendocrine tumors. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20 37169669
2020 DAXX inhibits cancer stemness and epithelial-mesenchymal transition in gastric cancer. British journal of cancer 20 32203224
2019 DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors. Neoplasia (New York, N.Y.) 20 31029033
2011 Blocking Daxx trafficking attenuates neuronal cell death following ischemia/reperfusion in rat hippocampus CA1 region. Archives of biochemistry and biophysics 20 21843499
2020 Telomere length alterations and ATRX/DAXX loss in pituitary adenomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 19 32203094
2019 Performance of DAXX Immunohistochemistry as a Screen for DAXX Mutations in Pancreatic Neuroendocrine Tumors. Pancreas 19 30747827