Affinage

YTHDF1

YTH domain-containing family protein 1 · UniProt Q9BYJ9

Length
559 aa
Mass
60.9 kDa
Annotated
2026-06-11
100 papers in source corpus 47 papers cited in narrative 48 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/7 claims corpus-supported (86%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

YTHDF1 is a cytoplasmic N6-methyladenosine (m6A) reader that occupies a central post-transcriptional node, predominantly enhancing the translation of m6A-modified target mRNAs in processes spanning synaptic plasticity, axon guidance, antitumor immunity, and tissue homeostasis (PMID:30401835, PMID:30843071, PMID:30728504). In neurons it binds m6A-marked transcripts and drives stimulus-dependent translation required for hippocampal learning and memory and for Robo3.1-dependent commissural axon guidance (PMID:30401835, PMID:30843071). Across cancers and other contexts it promotes translation of a broad set of targets—including cell-cycle regulators (CDK2/CDK4/cyclin D1, cyclin E2), Wnt effectors (FZD7, TCF7L2/TCF4), EZH2, NOTCH1, autophagy factors (ATG2A/ATG14), and NF-κB components (p65, TRAF6)—thereby controlling proliferation, stemness, autophagy, and inflammation (PMID:31653849, PMID:32788173, PMID:32064749, PMID:36634204, PMID:37459919, PMID:38241695, PMID:33619246, PMID:36717220, PMID:33999206). Mechanistically, YTHDF1 acts at translation initiation: it engages eIF3C and eIF5B and forms a feed-forward circuit with RUVBL1/2 at the 40S complex to accelerate oncogenic translation (PMID:31996915, PMID:39672819, PMID:38900944). Beyond translation, YTHDF1 undergoes liquid-liquid phase separation, is essential for P-body integrity, and recruits AGO2 through its YTH domain to mediate miRNA-dependent mRNA decay; it also assembles decapping/decay complexes (ZAP/DDX17/DCP2) to degrade viral m6A transcripts (PMID:34821414, PMID:33605073). YTHDF1 activity is tightly regulated: FMRP sequesters it from ribosomes until neuronal-stimulation-triggered phosphorylation releases it, O-GlcNAcylation at Ser196/197/198 controls Crm1-dependent cytoplasmic localization, and its protein stability is balanced by USP5 (stabilizing via K11-deubiquitination) and the CUL7-FBXW8 E3 ligase (degradation) (PMID:37949069, PMID:37086786, PMID:39900921). Upstream, HIF-1α transcriptionally induces YTHDF1 under hypoxia to drive autophagy and ferroptosis-resistance programs (PMID:33619246, PMID:38783692).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2018 High

    Established that YTHDF1 is a functional m6A reader in vivo by showing it drives stimulus-dependent translation of neuronal mRNAs required for synaptic plasticity and memory, settling whether m6A reading has physiological consequences.

    Evidence Ythdf1 knockout and hippocampal rescue, RIP-seq, nascent protein labeling, and tether reporter assays in mouse neurons

    PMID:30401835

    Open questions at the time
    • Did not resolve the initiation-factor machinery YTHDF1 recruits
    • Translation enhancement mechanism at the molecular level not defined
  2. 2019 High

    Extended YTHDF1 translational control to antitumor immunity and neural development, showing it tunes cathepsin levels to suppress antigen cross-presentation and drives Robo3.1 for axon guidance.

    Evidence Ythdf1 KO mice, syngeneic tumor and CD8+ priming assays, cathepsin inhibitor rescue, plus RIP and m6A-site mutation in spinal commissural neurons

    PMID:30728504 PMID:30843071

    Open questions at the time
    • How target selectivity among m6A transcripts is achieved was not defined
    • Direct lysosomal-gene m6A site mapping limited
  3. 2020 High

    Defined YTHDF1 as a pro-tumorigenic translational driver across multiple cancers by identifying direct targets including EIF3C, FZD7/Wnt effectors, and TFRC, linking m6A reading to global translation output and oncogenic signaling.

    Evidence CLIP-seq, MeRIP-seq, ribosome profiling, RIP, KO/overexpression in ovarian, gastric, intestinal, and squamous cancers

    PMID:31653849 PMID:31996915 PMID:32064749 PMID:32788173 PMID:33204330

    Open questions at the time
    • Some pathway placements (Keap1-Nrf2) rest on single labs
    • Whether YTHDF1 directly contacts initiation factors at these targets not always shown
  4. 2021 Medium

    Revealed that YTHDF1 also mediates mRNA degradation and phase separation, recruiting AGO2 via its YTH domain to build P-bodies and assembling decapping complexes to clear viral m6A RNA—expanding its role beyond translational enhancement.

    Evidence CRISPR KO with 4SU-TT-seq half-life measurement, YTH×AGO2 Co-IP domain mapping, FRAP/LLPS reconstitution, and Co-IP of ZAP/DDX17/DCP2 in EBV-infected cells

    PMID:33605073 PMID:34821414

    Open questions at the time
    • What dictates the translation-versus-decay decision is unresolved
    • LLPS and decay characterized in single labs
  5. 2021 High

    Placed YTHDF1 downstream of hypoxia signaling and within feed-forward circuits by showing HIF-1α transcriptionally induces it and that it amplifies Wnt and autophagy programs through ATG2A/ATG14 and TCF7L2.

    Evidence ChIP and luciferase reporters for HIF-1α binding, MeRIP-seq, polysome profiling, KO mouse intestinal and HCC models

    PMID:32064749 PMID:33619246

    Open questions at the time
    • Generality of the HIF-1α→YTHDF1 axis across tissues not fully tested
  6. 2022 Medium

    Connected YTHDF1 translational control to the tumor immune microenvironment and inflammasome biology, showing it drives p65/CXCL1-mediated MDSC recruitment and modulates NLRP3/IL-1β through several target mRNAs.

    Evidence Integrated MeRIP-seq/Ribo-seq, Ythdf1 knockin mice, scRNA-seq, in vivo siRNA delivery, plus inflammasome and reporter assays

    PMID:35444649 PMID:35508474 PMID:35649302 PMID:36717220

    Open questions at the time
    • Several inflammasome links lack direct m6A site mapping
    • Context-dependence of pro- versus anti-inflammatory output unresolved
  7. 2023 High

    Uncovered the regulatory logic governing YTHDF1 activity—FMRP sequestration relieved by phosphorylation, O-GlcNAcylation controlling Crm1-dependent localization—and demonstrated phase-separation-dependent translational repression of IκB in transdifferentiation.

    Evidence FMRP-YTHDF1 Co-IP with ribosome co-sedimentation and phospho-mutant rescue, OGT chemoproteomic site mapping with Crm1 assays, and YTH-domain LLPS reporter assays

    PMID:37060562 PMID:37086786 PMID:37949069

    Open questions at the time
    • How phosphorylation, O-GlcNAcylation, and LLPS integrate is not defined
    • Stoichiometry of FMRP-YTHDF1 regulation in non-neuronal cells unknown
  8. 2023 High

    Solidified YTHDF1 as an immunotherapeutic target by showing tumor-intrinsic YTHDF1 drives lysosomal MHC-I degradation and EZH2/IL-6-mediated CD8+ T-cell dysfunction, with siYTHDF1 synergizing with anti-PD-1.

    Evidence Tumor-cell KO with lysosomal/MHC-I assays, ribosome profiling, RIP-seq, liver-specific knockin mice, scRNA-seq, and LNP-siRNA combinations

    PMID:36650153 PMID:37459919 PMID:38241695

    Open questions at the time
    • Relative contribution of translational versus stability effects on NOTCH1 not fully separated
  9. 2024 High

    Mapped the translation-initiation machinery and stability control underlying YTHDF1 function, identifying eIF5B and a RUVBL1/2 40S feed-forward circuit, and defining USP5/CUL7-FBXW8 control of YTHDF1 protein levels.

    Evidence Co-IP/MS at the 40S complex, CRISPR screen, ribosome sequencing, pharmacological inhibition, and ubiquitin-linkage and kinase-substrate assays

    PMID:38900944 PMID:39672819 PMID:39900921

    Open questions at the time
    • Structural basis of YTHDF1 engagement with the initiation complex unresolved
    • Whether eIF5B and RUVBL1/2 act on overlapping target sets unknown
  10. 2024 Medium

    Broadened YTHDF1's organ-homeostasis roles and revealed additional layers of regulation, including PIEZO2/Cav1 in cardiac biology, structural remodeling by DHX36 enabling decay, NAT10/SRSF2-driven splicing of YTHDF1, and viral lactylation-driven degradation.

    Evidence Conditional cardiac KO, MeRIP site mapping, transcriptome-wide structure probing, splicing reporters, and PTM/viral-replication assays

    PMID:38768805 PMID:39024555 PMID:39496835 PMID:39498803 PMID:39543097

    Open questions at the time
    • DHX36-m6A-YTHDF1 decay link is correlative
    • Several tissue phenotypes rest on single labs

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved what molecular switch directs YTHDF1 between translational enhancement, mRNA decay, and phase-separation-mediated repression on a given transcript, and how target selectivity among the thousands of m6A-marked mRNAs is encoded.
  • No unifying model integrating translation, decay, and LLPS outputs
  • No structural model of YTHDF1 at the initiation complex
  • Determinants of context-specific target selection unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 5 GO:0045182 translation regulator activity 4 GO:0140098 catalytic activity, acting on RNA 3
Localization
GO:0005829 cytosol 2 GO:0005634 nucleus 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-168256 Immune System 4 R-HSA-392499 Metabolism of proteins 3 R-HSA-1640170 Cell Cycle 2 R-HSA-8953854 Metabolism of RNA 2 R-HSA-9612973 Autophagy 2
Partners
AGO2CRM1EIF3CEIF5BFMRPRUVBL1RUVBL2USP5
Complex memberships
40S translation initiation complexP-bodystress granule

Evidence

Reading pass · 48 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2018 YTHDF1 binds m6A-modified neuronal mRNAs and promotes their translation in response to neuronal stimulation in the adult mouse hippocampus; Ythdf1 knockout mice show impaired synaptic transmission, long-term potentiation, and learning/memory defects that are rescued by hippocampal re-expression of YTHDF1. Tether reporter assays in hippocampal neurons confirmed stimulus-dependent translation enhancement. Ythdf1 knockout mouse, hippocampus-specific AAV re-expression rescue, transcriptome-wide YTHDF1 RIP-seq and m6A mapping, nascent protein labeling, tether reporter assays in neurons Nature High 30401835
2019 In classical dendritic cells, YTHDF1 recognizes m6A-marked transcripts encoding lysosomal proteases (cathepsins) and promotes their translation, thereby increasing lysosomal cathepsin levels; this suppresses cross-presentation of tumor antigens. Ythdf1-deficient DCs show enhanced cross-priming of CD8+ T cells, and inhibition of cathepsins in wild-type DCs phenocopies YTHDF1 loss. Ythdf1 knockout mouse, syngeneic tumor models, polysome profiling / RIP, cathepsin inhibitor rescue experiments, in vivo CD8+ T cell priming assays Nature High 30728504
2019 YTHDF1 binds m6A-modified Robo3.1 mRNA in spinal commissural neurons and promotes its translation without affecting mRNA levels; mutation of m6A sites in Robo3.1 mRNA or YTHDF1 KD/KO abolishes Robo3.1 protein expression, causing pre-crossing axon guidance defects in the spinal cord. YTHDF1 RIP, m6A site mutation, YTHDF1 KD and KO in vivo (spinal commissural neuron-specific), axon guidance phenotyping Nucleic Acids Research High 30843071
2019 YTHDF1 promotes translation of CDK2, CDK4, and cyclin D1 in NSCLC cells; its depletion inhibits cell proliferation, xenograft tumor formation, and de novo lung adenocarcinoma progression. YTHDF1 depletion also activates the Keap1-Nrf2-AKR1C1 axis, rendering cells cisplatin-resistant. YTHDF1 knockdown/knockout, xenograft models, genetic mouse lung adenocarcinoma model, polysome profiling, western blot for CDK2/CDK4/cyclin D1 Nature Communications Medium 31653849
2020 YTHDF1 binds m6A-modified EIF3C mRNA and enhances its translation in an m6A-dependent manner, promoting overall translational output and ovarian cancer progression. Multi-omics analysis (CLIP-seq, m6A-seq, ribosome profiling, proteomics) confirmed EIF3C as a direct YTHDF1 target. Multi-omics: CLIP-seq, MeRIP-seq, ribosome profiling, proteomics, RIP, western blot, YTHDF1 overexpression/knockdown in ovarian cancer cells and patient samples Nucleic Acids Research High 31996915
2020 YTHDF1 promotes translation of the Wnt receptor FZD7 in an m6A-dependent manner in gastric cancer cells, activating the Wnt/β-catenin pathway and gastric carcinogenesis. Mutant YTHDF1 found in ~7% of gastric cancers shows enhanced FZD7 expression. YTHDF1 KD/overexpression, RIP, m6A-seq, reporter assay, FZD7 western blot, xenograft models Cancer Research Medium 32788173
2020 YTHDF1 facilitates translation of Wnt signaling effectors including TCF7L2/TCF4 in intestinal stem cells; genetic ablation of Ythdf1 blocks Wnt-driven intestinal regeneration and tumorigenesis, and YTHDF1 expression itself is upregulated by Wnt signaling at the translational level, forming an amplifying feed-forward loop. Ythdf1 knockout mouse, intestinal organoids, RIP-seq, ribosome profiling, intestinal tumor models EMBO Reports Medium 32064749
2020 YTHDF1 binds m6A-modified TRIM29 mRNA and promotes its translation in cisplatin-resistant ovarian cancer cells, enhancing cancer stem cell-like characteristics; YTHDF1 knockdown suppresses CSC features and is rescued by ectopic TRIM29 expression. RIP, m6A-IP, polysome profiling, YTHDF1 KD, TRIM29 rescue overexpression, CSC sphere assays Biochimica et Biophysica Acta. Molecular Cell Research Medium 33011193
2020 YTHDF1 binds to the 3'UTR and 5'UTR of TFRC mRNA via its methyltransferase domain and positively regulates translation of m6A-modified TFRC mRNA, enhancing iron metabolism and tumorigenesis in hypopharyngeal squamous cell carcinoma. m6A-seq, RIP-seq, gain/loss-of-function assays, iron metabolism assays, xenograft model Theranostics Medium 33204330
2021 In dendritic cells infected with EBV, YTHDF1 recognizes m6A-modified EBV transcripts, promotes RNA decapping, and mediates viral RNA decay by recruiting degradation complexes including ZAP, DDX17, and DCP2; this suppresses EBV replication in an m6A-dependent manner. m6A-seq on EBV transcripts, YTHDF1 RIP, co-immunoprecipitation of YTHDF1 with ZAP/DDX17/DCP2, mRNA half-life assays, YTHDF1 KD in NPC cells EMBO Reports Medium 33605073
2021 YTHDF1 directs translation of TRAF6 mRNA through recognition of m6A modification near the TRAF6 transcript's stop codon, regulating the intestinal immune response to bacterial infection. The P/Q/N-rich domain of YTHDF1 interacts with the DEAD domain of host factor DDX60, enabling recognition of the Traf6 transcript. Ribo-seq, m6A-seq, RIP-qPCR, domain-mapping Co-IP (P/Q/N-rich domain of YTHDF1 × DEAD domain of DDX60), bacterial infection mouse model Nucleic Acids Research Medium 33999206
2021 YTHDF1 promotes translation of MAGED1 mRNA in an m6A-dependent manner in pulmonary artery smooth muscle cells (PASMCs); this process is absent in METTL3-deficient PASMCs. YTHDF1 deletion ameliorates PASMC proliferation, phenotype switch, and pulmonary hypertension in vivo. m6A RIP-seq, YTHDF1 RIP, YTHDF1 KO mouse (pulmonary), METTL3-deficient PASMCs, MAGED1 KO mouse (hemodynamic phenotyping) American Journal of Respiratory and Critical Care Medicine Medium 33465322
2021 HIF-1α transcriptionally induces YTHDF1 expression by binding directly to the YTHDF1 promoter under hypoxia. YTHDF1 then promotes translation of ATG2A and ATG14 mRNAs via binding m6A-modified sites, facilitating hypoxia-induced autophagy and hepatocellular carcinoma malignancy. ChIP, luciferase reporter, MeRIP-seq, proteomics, polysome profiling, YTHDF1 KO/overexpression HCC models including PDX and organoids Signal Transduction and Targeted Therapy High 33619246
2021 YTHDF1 promotes mRNA degradation via interaction with AGO2 through its YTH domain, recruiting AGO2 to P-bodies; YTHDF1 undergoes liquid-liquid phase separation (LLPS) in vitro and in vivo and is critical for P-body formation. Deletion of YTHDF1 prolongs mRNA half-lives, converts P-bodies from liquid to gel/solid state, and impairs miRNA-mediated mRNA degradation. CRISPR KO of YTHDF1/METTL14, 4SU-TT-seq for mRNA half-lives, Co-IP domain mapping (YTH × AGO2), immunofluorescence co-localization, in vitro and in vivo LLPS assays, FRAP Cell Proliferation Medium 34821414
2021 YTHDF1 silencing inhibits Wnt/β-catenin pathway activity in colorectal cancer cells, and YTHDF1 promotes tumorigenicity and cancer stem cell-like activity. YTHDF1 knockdown, in vitro tumorigenicity assays, xenograft models, Wnt/β-catenin pathway reporters Frontiers in Oncology Low 31131257
2021 YTHDF1 promotes translation of cyclin E2 in an m6A-dependent manner in AML cells; structure-based virtual screening identified tegaserod as a YTHDF1 inhibitor that blocks direct binding of YTHDF1 to m6A-modified mRNAs and inhibits cyclin E2 translation, suppressing AML leukemic capacity. YTHDF1 KD in primary human and mouse AML cells, m6A-seq, RIP, ribosome profiling, structure-based virtual screening, tegaserod binding/functional assays, patient-derived xenograft models Cancer Research Medium 36634204
2021 YTHDF1 promotes ARHGEF2 mRNA translation by binding to m6A sites on ARHGEF2 mRNA, leading to enhanced RhoA signaling and colorectal cancer metastasis. Ectopic ARHGEF2 expression restores RhoA signaling and metastatic ability in YTHDF1-KO cells. Ythdf1 KO mouse (inflammatory CRC model), integrative multiomics (RNA-seq, MeRIP-seq, YTHDF1 RIP-seq, proteomics), ARHGEF2 rescue experiments, LNP-siRNA in vivo Gastroenterology High 34968454
2021 YTHDF1 modulates E2F8 mRNA stability in a METTL14-dependent manner, promoting DNA damage repair and S-phase entry in breast cancer; YTHDF1 KD sensitizes breast cancer cells to Adriamycin, Cisplatin, and Olaparib. YTHDF1 KD, METTL14 dependency assay, E2F8 mRNA stability assay, DNA damage repair assays, drug sensitivity assays in vitro and xenograft Cell Death & Disease Low 35279688
2022 YTHDF1 promotes translation of p65/RelA mRNA via m6A binding in colorectal cancer cells, leading to upregulation of CXCL1, which drives MDSC migration via CXCL1-CXCR2 axis, thereby suppressing cytotoxic CD8+ T cells in the tumor microenvironment. Integrated MeRIP-seq, RNA-seq, Ribo-seq; syngeneic tumor models; Ythdf1 knockin mice; scRNA-seq; CRISPR KO; VNP-siRNA delivery Gut High 36717220
2022 YTHDF1 promotes translation of FOXM1 mRNA through m6A recognition in breast cancer, accelerating the translation process; FOXM1 overexpression partially rescues the tumor-suppressing effects of YTHDF1 silencing. RIP, m6A-IP, CLIP, polysome profiling, Co-IP (YTHDF1-FOXM1 protein interaction), YTHDF1 KD + FOXM1 rescue in breast cancer cells Cell & Bioscience Medium 35197112
2022 YTHDF1 promotes translation of NLRP3 mRNA in macrophages during bacterial infection, facilitating pro-inflammatory IL-1β production; in vivo knockdown of YTHDF1 improves survival in a mouse sepsis model. YTHDF1 overexpression/KD, NLRP3 western blot, IL-1β ELISA, in vivo YTHDF1 KD in mouse sepsis model Biochemical and Biophysical Research Communications Low 35649302
2022 YTHDF1 recognizes m6A modification sites on SOCS3 mRNA and promotes its translation, thereby inhibiting the JAK2/STAT3 pathway and reducing secretion of inflammatory factors in Treponema pallidum-infected macrophages. RIP-qPCR, m6A-IP, YTHDF1 KD, METTL3 Co-IP, SOCS3 translation assay, JAK2/STAT3 pathway analysis in THP-1 macrophages Frontiers in Immunology Low 35444649
2022 YTHDF1 promotes translation of WWP1 mRNA in an m6A-dependent manner; increased WWP1 then promotes NLRP3 ubiquitination and degradation, inhibiting caspase-1-dependent pyroptosis and ameliorating sepsis. RIP-RT-qPCR, dual luciferase reporter, meRIP, ubiquitination assay, YTHDF1/WWP1 overexpression in LPS+ATP RAW264.7 cells and CLP mouse model Cell Death Discovery Low 35508474
2022 YTHDF1 upregulates expression of the Wnt receptor FZD7 to promote gastric cancer; VNPs delivering YTHDF1-siRNA suppress cancer progression and metastasis by hampering FZD7 translation and inactivating Wnt/β-catenin pathway in an m6A-dependent manner. Engineered sEV-siYTHDF1 delivery, FZD7 western blot, Wnt/β-catenin reporter, xenograft models Advanced Materials Low 36484103
2022 YTHDF1 regulates translation of MAGED1 via m6A modification in PASMCs; this is absent in METTL3-deficient PASMCs, confirming m6A-dependency. YTHDF1 also promotes Foxm1 translation in an m6A-dependent manner to drive hypoxia-induced PASMC proliferation. RNA pull-down, RIP, protein synthesis assay, si-YTHDF1 in hypoxic PASMCs, adenovirus si-YTHDF1 in vivo PAH mouse model, RVSP measurement Experimental Cell Research Medium 36736607
2022 YTHDF1 undergoes liquid-liquid phase separation (LLPS) and forms a dimeric complex with CLOCK mRNA in an m6A-dependent manner, shuttling to stress granules upon allergen challenge; YTHDF1 augments CLOCK translation to activate the NLRP3 inflammasome and IL-1β secretion in airway epithelial cells. YTHDF1 LLPS assays, co-immunoprecipitation, m6A-RIP, CLOCK translational reporter, NLRP3 inflammasome activation assays, in vivo allergic airway mouse model, CLOCK genetic deletion rescue Cell Reports Medium 38492220
2023 Tumor-intrinsic YTHDF1 promotes translation of lysosomal genes, enhancing lysosomal proteolysis of MHC-I and antigens; YTHDF1 deficiency inhibits this lysosomal pathway, restores MHC-I surface expression, and thereby reverses immune evasion, converting cold tumors into immunologically hot tumors. YTHDF1 KO in tumor cells, lysosomal gene expression analysis, MHC-I surface staining, lysosomal protease assays, exosome-mediated CRISPR/Cas9 delivery in vivo, immune infiltration profiling Nature Communications Medium 36650153
2023 YTHDF1 binds m6A-modified EZH2 mRNA and promotes EZH2 translation; elevated EZH2 then increases IL-6 secretion, which recruits and activates MDSCs to cause CD8+ T-cell dysfunction in NASH-HCC. LNP-encapsulated siYTHDF1 combined with anti-PD-1 shows synergistic antitumor efficacy. RNA-seq, m6A-seq, YTHDF1 RIP-seq, proteomics, ribosome profiling; liver-specific Ythdf1 knockin mice; scRNA-seq; flow cytometry; LNP-siRNA in vivo Journal of Hepatology High 37459919
2023 FMRP physically interacts with YTHDF1 and sequesters it away from ribosomes, suppressing YTHDF1-driven translation of m6A target mRNAs. Upon neuronal stimulation, FMRP becomes phosphorylated and releases YTHDF1, enabling translation upregulation. A small-molecule YTHDF1 inhibitor reverses FXS developmental defects in an organoid model. Co-immunoprecipitation (FMRP-YTHDF1), ribosomal co-sedimentation assays, phosphorylation-mimetic/dead FMRP mutants, YTHDF1 small-molecule inhibitor, FXS organoid model Molecular Cell High 37949069
2023 YTHDF1 promotes translation of cyclin E2 in AML (also confirmed above) and can be pharmacologically inhibited by tegaserod which blocks YTHDF1-m6A-mRNA interaction. YTHDF1 is enriched in AML leukemia stem cells and is dispensable for normal hematopoiesis. Structure-based virtual screening, binding competition assay, primary AML cell KD, ribosome profiling, PDX models Cancer Research Medium 36634204
2023 YTHDF1 undergoes LLPS to promote transdifferentiation of spermatogonial stem cells into neural stem cell-like cells; LLPS-mediated YTHDF1 inhibits translation of IκBα/β mRNAs, activating the NF-κB-CCND1 axis. The YTH domain alone promotes IκBα/β translation and inhibits transdifferentiation. YTHDF1 LLPS characterization in vitro and in vivo, IκBα/β translational reporter assays, YTHDF1 YTH domain overexpression, NF-κB activation assays, transdifferentiation efficiency readout, tau-YTH fusion LLPS rescue Cell Reports Medium 37060562
2023 m6A-modified circSAV1 forms a ternary complex with YTHDF1 and IREB2 mRNA, facilitating IREB2 translation; elevated IREB2 disrupts iron homeostasis and drives ferroptosis in lung epithelial cells, contributing to COPD progression. circRNA-seq, YTHDF1 RIP, Co-IP/complex formation assay, IREB2 translation assay, iron homeostasis assays, ferroptosis markers, circSAV1 KD in CS-induced COPD mouse model Cell Death and Differentiation Medium 36828914
2023 YTHDF1 promotes NOTCH1 mRNA stability and translation by binding m6A-modified NOTCH1 mRNA in liver cancer stem cells, driving HCC stemness and drug resistance; catalytically inactive YTHDF1 mutant abolishes these effects. RIP-seq, MeRIP-seq, ribosome profiling, RNA-seq; catalytically inactive YTHDF1 mutant; NOTCH1 rescue experiments; patient-derived organoids; LNP-siYTHDF1 in vivo Cancer Research High 38241695
2023 O-GlcNAcylation of YTHDF1 at Ser196/Ser197/Ser198 (catalyzed by OGT) promotes cytosolic localization of YTHDF1 by enhancing its interaction with exportin Crm1, increasing expression of downstream target c-Myc in colorectal cancer. OGT Co-IP, chemoproteomic site mapping (Ser196/197/198), O-GlcNAc-deficient AFA mutant construction, nuclear export Crm1 interaction assays, molecular dynamics simulation, xenograft assay Journal of Biological Chemistry Medium 37086786
2024 In dendritic cells, IR (ionizing radiation) upregulates YTHDF1 expression via STING/IFN-I signaling. YTHDF1 in turn promotes translation of lysosomal cathepsins, which degrade STING, thereby reducing IFN-I production—creating a negative feedback loop. YTHDF1-deficient DCs show enhanced cross-priming and antitumor effects of radiotherapy. DC-specific Ythdf1 KO, STING/IFN-I pathway analysis, lysosomal cathepsin activity, STING degradation assay, murine tumor models, YTHDF1-deletion DC vaccine prototype Journal of Clinical Investigation Medium 39325547
2024 YTHDF1 binds m6A-modified PIEZO2 mRNA at site peak_26355 and promotes PIEZO2 translation; this drives cardiac fibroblast autophagy and cardiac fibrosis. Fibroblast-specific AAV9-shYTHDF1 reduces Piezo2 expression and ameliorates cardiac fibrosis. MeRIP-seq, site-specific m6A mapping (peak_26355), RIP, YTHDF1 KD rescue with PIEZO2 re-expression, AAV9-shYTHDF1 in ISO/Ang-II/TAC mouse models, single-cell sequencing Cardiovascular Research Medium 39498803
2024 USP5 interacts with and stabilizes YTHDF1 by removing K11-linked polyubiquitination; mTORC1 phosphorylates USP5, promoting its dimerization and protection of YTHDF1 from degradation. Conversely, CUL7-FBXW8 E3 ligase promotes YTHDF1 degradation. USP5-YTHDF1 Co-IP, ubiquitin linkage assays (K11-specific), mTORC1/USP5 phosphorylation assay, USP5 dimerization assay, CUL7-FBXW8 E3 ligase assay, YTHDF1 protein stability assays Nature Communications Medium 39900921
2024 YTHDF1 promotes EGFR mRNA translation by binding m6A sites in the 3'-UTR of EGFR transcript in intrahepatic cholangiocarcinoma cells; overexpression of wild-type but not m6A reader domain mutant YTHDF1 enhances tumor growth, confirming m6A reading is required. m6A-seq, RIP-seq, RNA-seq, YTHDF1 overexpression vs. m6A reader domain mutant, orthotopic ICC mouse model (AKT/YAP hydrodynamic transfection) Journal of Gastroenterology and Hepatology Medium 35233828
2024 HIF-1α directly binds the YTHDF1 promoter and transcriptionally induces YTHDF1 expression in nucleus pulposus cells; YTHDF1 then promotes translation of SLC7A11 mRNA via m6A binding, leading to GPX4 upregulation and suppression of ferroptosis in NPCs. Luciferase reporter, ChIP, polysome profiling, MeRIP, YTHDF1 KD/OE in NPC cells, in vivo disc degeneration model Aging Cell Medium 38783692
2024 NAT10 undergoes liquid-liquid phase separation via its C-terminal IDR, interacts with splicing factor SRSF2, and acetylates SRSF2; acetylated SRSF2 binds the YTHDF1 pre-mRNA and promotes exon 4 skipping, producing a short YTHDF1 transcript that stimulates gastric cancer cell proliferation and migration. NAT10 LLPS characterization, Co-IP (NAT10-SRSF2), acetyltransferase assay, RNA-binding assay of SRSF2 on YTHDF1 pre-mRNA, splicing reporter, patient gastric cancer samples Cancer Research Medium 39024555
2024 YTHDF1 binds to m6A-modified RUVBL1 and RUVBL2 mRNAs to promote their translation initiation; RUVBL1/2 reciprocally interact with YTHDF1 at 40S translation initiation complexes, forming a positive feedforward circuit that accelerates oncogenic translation. RUVBL1/2 depletion stalls YTHDF1-driven translation of MAPK, RAS, and PI3K-AKT targets. CRISPR screen, Co-IP + mass spectrometry (RUVBL1/2 at 40S complexes), ribosome sequencing, RIP for m6A-modified RUVBL1/2 mRNA, patient-derived organoids, xenograft, CB6644 pharmacological inhibition Cancer Research High 38900944
2024 SFTSV virulence factor NSs induces lactylation of YTHDF1 and promotes YTHDF1 degradation, thereby reducing YTHDF1-mediated destabilization of m6A-modified SFTSV mRNAs and facilitating viral replication. YTHDF1 normally binds m6A sites on SFTSV RNA, decreasing viral RNA stability and translation. MeRIP-seq on SFTSV RNA, YTHDF1 RIP on SFTSV RNA, lactylation assay of YTHDF1, YTHDF1 stability assay after NSs expression, viral replication assays EMBO Reports Medium 39496835
2024 YTHDF1 binds to m6A-modified Caveolin 1 (Cav1) mRNA in cardiomyocytes and promotes its translation; cardiac-restricted YTHDF1 deletion leads to reduced Cav1 expression, impaired membrane raft proteins, and downstream ERK signaling dysregulation, resulting in cardiac hypertrophy, fibrosis, and dysfunction. Cardiac-restricted Ythdf1 KO mouse (newly generated), mass spectrometry, m6A-RIP on Cav1 mRNA, Cav1 translational assay, ERK signaling analysis Journal of Molecular and Cellular Cardiology Medium 38768805
2024 YTHDF1 promotes translation of EZH2 and CDH11 by reading m6A-enriched sites of their transcripts in breast cancer cells, facilitating osteolytic bone metastasis. AAV-delivered shYTHDF1 suppresses bone metastatic formation in intratibial injection models. RNA-seq, MeRIP-seq, RIP-seq, molecular biology validation, YTHDF1 KD + EZH2/CDH11 rescue, AAV-shYTHDF1 in vivo model Cancer Letters Medium 38871245
2024 DHX36 helicase binding induces structural remodeling of 3'UTR regions of mRNAs, increasing accessibility at m6A sites and facilitating YTHDF1 binding, which leads to decreased mRNA abundance (degradation). Transcriptome-wide RNA structure probing, YTHDF1 RIP, DHX36 KD, correlation of DHX36 binding sites with m6A and YTHDF1 binding, mRNA abundance analysis Nature Communications Medium 39543097
2024 YTHDF1 interacts with eukaryotic translation initiation factor eIF5B (identified by Co-IP + mass spectrometry), and this complex promotes PD-L1 mRNA translation; additionally, methionine-driven YTHDF1 upregulation promotes degradation of RIG-I mRNA, inhibiting the RIG-I/MAVS IFN-I pathway to suppress tumor immunotherapy. Co-IP + mass spectrometry (YTHDF1–eIF5B), PD-L1 translational reporter, RIG-I mRNA stability assay, YTHDF1 RNA-seq, point mutations, MB49 mouse tumor models, single-cell RNA-seq Cell Death and Differentiation Medium 39672819
2024 YTHDF1 promotes translation of HSPH1 in an m6A-dependent manner in MNU-induced gastric carcinogenesis; RIP-qPCR confirms HSPH1 as a direct YTHDF1 target, and HSPH1 KD impairs malignant potential of transformed cells. RNA-seq, RNA immunoprecipitation (RIP-qPCR), proteomics, YTHDF1 KD, HSPH1 KD, long-term MNU transformation model Cell Proliferation Low 38444279
2024 WTAP methylates NLRP3 mRNA at m6A sites and YTHDF1 YTH domain directly binds NLRP3 mRNA to promote NLRP3 protein translation after TBI; YTHDF1 mutation or silencing suppresses NLRP3 translation, inhibits caspase-1 activation, and decreases IL-1β, improving neuronal injury outcomes. Conditional WTAP KO (Camk2a-Cre), pAAV-shYTHDF1, RIP (YTH domain binding to NLRP3 mRNA), western blot for NLRP3, caspase-1, IL-1β in TBI mouse model International Journal of Surgery Low 38874470

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2019 Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells. Nature 801 30728504
2020 The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Nucleic acids research 592 31996915
2018 m6A facilitates hippocampus-dependent learning and memory through YTHDF1. Nature 443 30401835
2021 HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation. Signal transduction and targeted therapy 336 33619246
2019 YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression. Nature communications 308 31653849
2019 YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma. Frontiers in oncology 212 31131257
2023 Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer. Gut 208 36717220
2020 YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7. Cancer research 201 32788173
2019 The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression. Nucleic acids research 161 30843071
2021 N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer. Gastroenterology 159 34968454
2022 YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance. Cell death & disease 137 35279688
2023 H3K18 lactylation promotes the progression of arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP. Journal of hazardous materials 132 37742376
2023 N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2. Cell death and differentiation 131 36828914
2023 Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis. Journal of hepatology 122 37459919
2020 m6A-YTHDF1-mediated TRIM29 upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells. Biochimica et biophysica acta. Molecular cell research 116 33011193
2021 YTHDF1 Regulates Pulmonary Hypertension through Translational Control of MAGED1. American journal of respiratory and critical care medicine 111 33465322
2020 YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness. EMBO reports 105 32064749
2021 The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases. Molecular therapy. Nucleic acids 95 34853726
2023 Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation. Nature communications 91 36650153
2022 YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner. Cell & bioscience 91 35197112
2021 N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay. EMBO reports 89 33605073
2021 The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response. Nucleic acids research 89 33999206
2022 Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells. Journal for immunotherapy of cancer 87 35193930
2020 YTHDF1-enhanced iron metabolism depends on TFRC m6A methylation. Theranostics 85 33204330
2022 m6 A Reader YTHDF1-Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation. Advanced materials (Deerfield Beach, Fla.) 83 36484103
2021 YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation. Cell proliferation 83 34821414
2024 N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression. Cancer research 81 38241695
2021 YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer. Oncoimmunology 80 34408926
2023 The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression. Cancer research 79 36634204
2021 YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition. Experimental hematology & oncology 79 34088349
2018 MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m6A-YTHDF1-dependent mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 76 30339471
2022 YTHDF1 alleviates sepsis by upregulating WWP1 to induce NLRP3 ubiquitination and inhibit caspase-1-dependent pyroptosis. Cell death discovery 73 35508474
2022 YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis. Cell death & disease 72 35319018
2023 FMRP phosphorylation modulates neuronal translation through YTHDF1. Molecular cell 71 37949069
2024 WTAP participates in neuronal damage by protein translation of NLRP3 in an m6A-YTHDF1-dependent manner after traumatic brain injury. International journal of surgery (London, England) 52 38874470
2023 The function and clinical implication of YTHDF1 in the human system development and cancer. Biomarker research 48 36650570
2023 N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner. Apoptosis : an international journal on programmed cell death 48 37698736
2022 YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner. Frontiers in immunology 48 35444649
2024 HIF-1α-induced expression of the m6A reader YTHDF1 inhibits the ferroptosis of nucleus pulposus cells by promoting SLC7A11 translation. Aging cell 46 38783692
2020 Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation. RNA biology 44 33295243
2022 METTL3 promotes cell cycle progression via m6A/YTHDF1-dependent regulation of CDC25B translation. International journal of biological sciences 42 35637959
2022 RNA Editing Enzyme ADAR1 Regulates METTL3 in an Editing Dependent Manner to Promote Breast Cancer Progression via METTL3/ARHGAP5/YTHDF1 Axis. International journal of molecular sciences 38 36077054
2020 Increased expression of YTHDF1 and HNRNPA2B1 as potent biomarkers for melanoma: a systematic analysis. Cancer cell international 37 32549786
2021 Potential Impact of ALKBH5 and YTHDF1 on Tumor Immunity in Colon Adenocarcinoma. Frontiers in oncology 36 34079761
2023 O-GlcNAcylation promotes the cytosolic localization of the m6A reader YTHDF1 and colorectal cancer tumorigenesis. The Journal of biological chemistry 34 37086786
2023 The potential role of m6A reader YTHDF1 as diagnostic biomarker and the signaling pathways in tumorigenesis and metastasis in pan-cancer. Cell death discovery 33 36707507
2022 Involvement of YTHDF1 in renal fibrosis progression via up-regulating YAP. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 34990050
2022 N6-Methyladenosine RNA-Binding Protein YTHDF1 in Gastrointestinal Cancers: Function, Molecular Mechanism and Clinical Implication. Cancers 29 35884552
2022 m6A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation. Cell reports 29 36417851
2023 A novel MYCN-YTHDF1 cascade contributes to retinoblastoma tumor growth by eliciting m6A -dependent activation of multiple oncogenes. Science China. Life sciences 28 36949231
2022 Methylation recognition protein YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) regulates the proliferation, migration and invasion of osteosarcoma by regulating m6A level of CCR4-NOT transcription complex subunit 7 (CNOT7). Bioengineered 28 35156522
2023 YTHDF1 Promotes Bladder Cancer Cell Proliferation via the METTL3/YTHDF1-RPN2-PI3K/AKT/mTOR Axis. International journal of molecular sciences 27 37108067
2022 METTL3 promotes proliferation and myogenic differentiation through m6A RNA methylation/YTHDF1/2 signaling axis in myoblasts. Life sciences 27 35351467
2021 YTHDF1 promotes the proliferation, migration, and invasion of prostate cancer cells by regulating TRIM44. Genes & genomics 27 34677810
2024 NAT10 Phase Separation Regulates YTHDF1 Splicing to Promote Gastric Cancer Progression. Cancer research 26 39024555
2022 Mesenchymal stem cells-derived HIF-1α-overexpressed extracellular vesicles ameliorate hypoxia-induced pancreatic β cell apoptosis and senescence through activating YTHDF1-mediated protective autophagy. Bioorganic chemistry 26 36244321
2022 Comprehensive Analysis of YTHDF1 Immune Infiltrates and ceRNA in Human Esophageal Carcinoma. Frontiers in genetics 24 35401696
2022 YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis. Archives of biochemistry and biophysics 24 36368367
2024 RBMS1 Coordinates with the m6A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 23 38342601
2023 YTHDF1 Attenuates TBI-Induced Brain-Gut Axis Dysfunction in Mice. International journal of molecular sciences 23 36835655
2024 hucMSC-Ex alleviates inflammatory bowel disease in mice by enhancing M2-type macrophage polarization via the METTL3-Slc37a2-YTHDF1 axis. Cell biology and toxicology 22 39259386
2024 YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production. The Journal of clinical investigation 22 39325547
2024 Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication. EMBO reports 22 39496835
2023 METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome. Experimental cell research 22 37044315
2022 RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation. Biochemical and biophysical research communications 22 35649302
2022 The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray. Journal of neuroinflammation 22 36550542
2024 Photosensitive and dual-targeted chromium nanoparticle delivering small interfering RNA YTHDF1 for molecular-targeted immunotherapy in liver cancer. Journal of nanobiotechnology 20 38898486
2024 YTHDF1 regulates GID8-mediated glutamine metabolism to promote colorectal cancer progression in m6A-dependent manner. Cancer letters 20 39151722
2022 METTL3 promotes non-small cell lung cancer (NSCLC) cell proliferation and colony formation in a m6A-YTHDF1 dependent way. BMC pulmonary medicine 20 36008805
2024 DUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma. Cancer cell international 19 38872157
2024 WTAP/YTHDF1-mediated m6A modification amplifies IFN-γ-induced immunosuppressive properties of human MSCs. Journal of advanced research 19 38944238
2022 YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation. Journal of gastroenterology and hepatology 19 35233828
2024 Epitranscriptomic regulation of cardiac fibrosis via YTHDF1-dependent PIEZO2 mRNA m6A modification. Cardiovascular research 18 39498803
2023 Propofol suppresses OGD/R-induced ferroptosis in neurons by inhibiting the HIF-1α/YTHDF1/BECN1 axis. Brain injury 18 37614036
2021 The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1. Brain research 18 34953798
2024 YTHDF1 boosts the lactate accumulation to potentiate cervical cancer cells immune escape. Cell death & disease 17 39557826
2022 Silencing of YTHDF1 Attenuates Cerebral Stroke by Inducing PTEN Degradation and Activating the PTEN/AKT/mTOR Pathway. Molecular biotechnology 17 36261761
2024 YTHDF1-CLOCK axis contributes to pathogenesis of allergic airway inflammation through LLPS. Cell reports 16 38492220
2024 YTHDF1 promotes the osteolytic bone metastasis of breast cancer via inducing EZH2 and CDH11 translation. Cancer letters 16 38871245
2024 FTO mediates bisphenol F-induced blood-testis barrier impairment through regulating ferroptosis via YTHDF1/TfRc and YTHDF2/SLC7A11 signal axis. Environmental pollution (Barking, Essex : 1987) 16 38996995
2023 Inhibition of YTHDF1 prevents hypoxia-induced pulmonary artery smooth muscle cell proliferation by regulating Foxm1 translation in an m6A-dependent manner. Experimental cell research 16 36736607
2023 PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis. Carcinogenesis 16 36999803
2024 KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma. Cell biology and toxicology 15 39060874
2023 YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis. Cell reports 15 37060562
2021 YTHDF1 gene polymorphisms and neuroblastoma susceptibility in Chinese children: an eight-center case-control study. Journal of Cancer 15 33758623
2024 METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1. Cancer gene therapy 14 38267624
2024 RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis. Cancer research 14 38900944
2024 Methionine-driven YTHDF1 expression facilitates bladder cancer progression by attenuating RIG-I-modulated immune responses and enhancing the eIF5B-PD-L1 axis. Cell death and differentiation 14 39672819
2023 Usf2 Deficiency Promotes Autophagy to Alleviate Cerebral Ischemia-Reperfusion Injury Through Suppressing YTHDF1-m6A-Mediated Cdc25A Translation. Molecular neurobiology 14 37914905
2024 YTHDF1 mediates N-methyl-N-nitrosourea-induced gastric carcinogenesis by controlling HSPH1 translation. Cell proliferation 13 38444279
2024 Gegen Qinlian Decoction reverses oxaliplatin resistance in colorectal cancer by inhibiting YTHDF1-regulated m6A modification of GLS1. Phytomedicine : international journal of phytotherapy and phytopharmacology 13 39089089
2024 Targeting METTL3 enhances the chemosensitivity of non-small cell lung cancer cells by decreasing ABCC2 expression in an m6A-YTHDF1-dependent manner. International journal of biological sciences 13 39309428
2023 YTHDF1 mitigates acute kidney injury via safeguarding m6A-methylated mRNAs in stress granules of renal tubules. Redox biology 13 37857002
2022 MEF2C Expression Is Regulated by the Post-transcriptional Activation of the METTL3-m6A-YTHDF1 Axis in Myoblast Differentiation. Frontiers in veterinary science 13 35573410
2022 Mettl3 regulates hypertrophic differentiation of chondrocytes through modulating Dmp1 mRNA via Ythdf1-mediated m6A modification. Bone 13 35981698
2025 USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation. Nature communications 12 39900921
2024 YTHDF1 is pivotal for maintenance of cardiac homeostasis. Journal of molecular and cellular cardiology 12 38768805
2024 DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1. Nature communications 12 39543097
2022 Wnt3a/YTHDF1 Regulated Oxaliplatin-Induced Neuropathic Pain Via TNF-α/IL-18 Expression in the Spinal Cord. Cellular and molecular neurobiology 12 35939138
2024 YTHDF1 facilitates esophageal cancer progression via augmenting m6A-dependent TINAGL1 translation. Cellular signalling 11 39098703

Missed literature

Know a paper Affinage missed for YTHDF1? Flag it for the maintainers and the community.

No submissions yet.