Affinage

PSPC1

Paraspeckle component 1 · UniProt Q8WXF1

Length
523 aa
Mass
58.7 kDa
Annotated
2026-06-10
45 papers in source corpus 23 papers cited in narrative 24 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/7 claims corpus-supported (86%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PSPC1 is a multifunctional nuclear DBHS-family scaffold protein that dimerizes through its conserved DBHS domain — comprising tandem RRMs, a NOPS motif, and a coiled-coil — with the related paralogs NONO and SFPQ, and these dimers underlie its roles in paraspeckle biology, genome maintenance, transcriptional control, and RNA metabolism (PMID:16148043, PMID:22102035, PMID:29530979, PMID:34904671). Heterodimerization with NONO is required, together with an RNA-binding-competent RRM and ongoing RNA Pol II transcription, for targeting to paraspeckles (PMID:16148043), and biophysical analyses show PSPC1 preferentially partners SFPQ over SFPQ self-association and that RRM1 with an adjacent β-clasp mediates cooperative nucleic-acid recognition (PMID:29530979, PMID:34904671). In genome maintenance, PSPC1 functionally substitutes for NONO in a stable SFPQ-containing complex that promotes DNA double-strand break repair within the DNA-PK pathway and enforces the G1/S DNA damage checkpoint (PMID:24819514, PMID:25100870). PSPC1 acts as a contextual signalling switch in cancer: it binds phospho-Smad2/3 to redirect TGF-β1 signalling toward pro-metastatic gene programs (PMID:29593326), sequesters the kinase PTK6 and shuttles β-catenin to drive Wnt autocrine signalling and EMT (PMID:31844057), and co-occupies chromatin with PU.1 to sustain a leukemic transcription program whose loss triggers myeloid differentiation without affecting normal hematopoiesis (PMID:39954676). It additionally serves as a regulatory subunit of the m6A demethylase ALKBH5, preferentially engaging K235-acetylated ALKBH5 to recruit m6A-modified mRNA for demethylation (PMID:37369679), and recruits catalytically active telomerase to telomeres via the hTR RNA component (PMID:40593584). Beyond malignancy, PSPC1 governs adipocyte and stem-cell fate through differentiation-dependent nucleocytoplasmic shuttling, association with the RNA export factor DDX3X, and interactions with TET1/PRC2 and SMAD3 (PMID:28192372, PMID:35675764, PMID:41345872). PSPC1 protein levels are controlled by an SKP2–TRIM21 ubiquitination axis, and the protein can undergo prion-like-domain-dependent liquid–liquid phase separation (PMID:34490876, PMID:38360141).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2005 High

    Established the molecular basis for paraspeckle assembly by defining how PSPC1 is recruited there, answering whether dimerization alone suffices.

    Evidence Co-IP and domain mapping with DRB transcription inhibition and fluorescence microscopy

    PMID:16148043

    Open questions at the time
    • Did not resolve which RNAs nucleate paraspeckle targeting
    • Functional consequence of paraspeckle residence not addressed
  2. 2006 Medium

    First showed PSPC1 acts as a transcriptional coactivator, extending DBHS function beyond paraspeckle structure to gene regulation.

    Evidence Co-IP and androgen-responsive luciferase reporter assays in Sertoli cells with testis immunohistochemistry

    PMID:16641145

    Open questions at the time
    • Direct DNA binding versus scaffold role at AR target genes unresolved
    • No genome-wide occupancy data
  3. 2011 Medium

    Provided the first atomic view of how PSPC1 and NONO dimerize, defining the DBHS interface structurally.

    Evidence X-ray crystallography of the PSPC1–NONO heterodimer to 1.9 Å

    PMID:22102035

    Open questions at the time
    • Functional validation of the interface not in this study
    • No insight into RNA engagement
  4. 2014 High

    Defined PSPC1's role in genome maintenance, showing it enforces the G1/S checkpoint yet acts outside canonical γH2AX/53BP1/Rad51 foci, and functionally substitutes for NONO in DNA-PK-dependent DSB repair.

    Evidence siRNA/KO MEFs, flow-cytometry cell-cycle analysis, clonogenic radiosensitivity, foci resolution, and DNA-PK inhibitor epistasis

    PMID:24819514 PMID:25100870

    Open questions at the time
    • Biochemical step in DSB repair where PSPC1 acts not defined
    • Redundancy logic between PSPC1 and NONO not fully mapped
  5. 2017 High

    Revealed PSPC1 as a nucleocytoplasmic regulator of RNA fate in differentiation, coupling RNA binding to DDX3X-dependent export and metabolic phenotype.

    Evidence CLIP-seq, DDX3X Co-IP, subcellular fractionation/live imaging, and adipose-specific knockout mouse

    PMID:28117896 PMID:28192372

    Open questions at the time
    • Signal triggering nuclear-to-cytoplasm relocation unknown
    • Direct RNA export mechanism vs. indirect not fully resolved
  6. 2018 High

    Demonstrated PSPC1 as a contextual signalling switch in cancer, redirecting TGF-β/Smad2/3 toward pro-metastatic programs, and structurally explained why PSPC1 preferentially partners SFPQ.

    Evidence Reciprocal Co-IP with pSmad2/3, ChIP-seq, mouse cancer models, plus SFPQ/PSPC1 crystal structure and analytical ultracentrifugation

    PMID:29530979 PMID:29593326

    Open questions at the time
    • How PSPC1 mechanically alters Smad2/3 promoter preference not detailed
    • Stoichiometry of signalling complexes in vivo unknown
  7. 2019 High

    Showed PSPC1 controls oncogenic signalling by spatially partitioning PTK6 and β-catenin, and identified a peptide (CT131) that reverses the metastatic phenotype.

    Evidence Co-IP, subcellular fractionation, Y523F mutagenesis, and HCC orthotopic mouse model with CT131 expression

    PMID:31844057

    Open questions at the time
    • Determinants of context-dependent nuclear vs. cytoplasmic shuttling unresolved
    • Generality across tumor types beyond HCC limited
  8. 2020 Medium

    Linked PSPC1 to focal adhesion/FAK-Src signalling via transcriptional upregulation of IGF1R in a paraspeckle-component-dependent manner.

    Evidence Phospho-kinase array, RNA-seq, proteomics, and NONO/FUS/NEAT1 knockdown

    PMID:32570949

    Open questions at the time
    • Direct vs. indirect transcriptional control of IGF1R unclear
    • Single-lab observation
  9. 2021 Medium

    Connected PSPC1 phase separation to checkpoint signalling, showing its prion-like domain is required to regulate CHK1 phosphorylation via PPP5C.

    Evidence Co-IP, PrLD deletion mutants, in vitro phase separation, and mouse oocyte maturation assays

    PMID:34490876

    Open questions at the time
    • Physiological scope of phase separation beyond oocytes unknown
    • Mechanistic link between condensates and PP5 activity not defined
  10. 2022 High

    Defined PSPC1's epigenetic role in stem-cell fate through TET1 and PRC2 occupancy at bivalent promoters, and refined the structural mechanism of RNA recognition by DBHS homodimers.

    Evidence TET1 interactome proteomics, genome-wide ChIP-seq, ESC loss-of-function, plus NONO/PSPC1 homodimer crystal structures and SAXS

    PMID:34904671 PMID:35675764

    Open questions at the time
    • Whether PSPC1 directly recruits PRC2 or acts via RNA scaffolding unclear
    • RRM1/β-clasp RNA specificity for endogenous targets not mapped
  11. 2023 High

    Identified PSPC1 as a regulatory subunit of the m6A eraser ALKBH5 sensitive to acetylation state, linking it to epitranscriptomic control of tumorigenesis.

    Evidence Co-IP with acetylated ALKBH5, m6A demethylation assays, K235 mutagenesis, and KAT8/HDAC7 identification

    PMID:37369679

    Open questions at the time
    • mRNA target repertoire of the PSPC1–ALKBH5 axis not enumerated
    • Acetylation dynamics in physiological contexts unknown
  12. 2024 Medium

    Established post-translational control of PSPC1 abundance through an SKP2–TRIM21 ubiquitination axis, and a non-DBHS RNA function in restricting HCV IRES translation.

    Evidence Co-IP and ubiquitination assays with SKP2 depletion; UV-crosslinking competition with RPS5 and polysome profiling

    PMID:38360141 PMID:38793620

    Open questions at the time
    • Signals governing SKP2 vs. TRIM21 balance not defined
    • Whether IRES competition reflects a broader antiviral role unknown
  13. 2025 High

    Expanded PSPC1's regulatory reach to leukemic transcription with PU.1, telomere maintenance via hTR, adipocyte beiging via SMAD3, and immune modulation via PARP1/STAT3.

    Evidence ChIP-seq with PU.1 and AML KO models; telomerase/hTR Co-IP with telomere-length assays; SMAD3 Co-IP with multi-omics and in vivo overexpression; PARP1 Co-IP with STAT3 and macrophage co-culture

    PMID:39954676 PMID:40593584 PMID:41345872 PMID:41986651

    Open questions at the time
    • Unifying logic across these context-specific partnerships unclear
    • Therapeutic window for targeting PSPC1 in AML versus normal cells not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved whether PSPC1's diverse partner-specific functions reflect distinct molecular states (dimer composition, acetylation, phase separation, localization) and how a single scaffold is partitioned among them in a given cell.
  • No integrated model linking dimer identity to functional outcome
  • Determinants of nucleocytoplasmic vs. condensate partitioning unknown
  • Endogenous RNA/protein interactome under defined states not catalogued

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 5 GO:0140110 transcription regulator activity 4 GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005634 nucleus 4 GO:0005654 nucleoplasm 2 GO:0005829 cytosol 2
Pathway
R-HSA-1643685 Disease 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-162582 Signal Transduction 3 R-HSA-73894 DNA Repair 2 R-HSA-8953854 Metabolism of RNA 2
Partners
ALKBH5DDX3XNONOPARP1PTK6SFPQSMAD3TET1
Complex memberships
DBHS dimer (PSPC1–NONO / PSPC1–SFPQ)PRC2-associated bivalent promoter complexSFPQ–PSPC1 DSB repair complexparaspeckle

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 PSPC1 (PSP1) forms a heterodimer with p54nrb (NONO) in vivo; the DBHS domain of PSPC1 mediates this interaction. This interaction is necessary but not sufficient for paraspeckle targeting, which also requires an RNA-binding-competent RRM domain. Paraspeckle formation itself is dependent on RNA Polymerase II transcription. Co-immunoprecipitation, domain-mapping experiments, DRB-mediated transcription inhibition assay, fluorescence microscopy Molecular biology of the cell High 16148043
2006 PSPC1 interacts with androgen receptor (AR) and with NONO and SFPQ in Sertoli cells, forming complexes that coactivate AR-mediated transcription; PSPC1 is the most effective coactivator among the three DBHS proteins in this context. Co-immunoprecipitation, luciferase reporter assay with androgen-responsive elements, immunohistochemistry of mouse testis sections Biology of reproduction Medium 16641145
2011 The PSPC1–NONO heterodimer was crystallized, confirming that the conserved DBHS domain (comprising two tandem RRMs, a NOPS domain, and part of a coiled-coil) provides the dimerization interface for these two paraspeckle proteins. Protein crystallography (crystal diffraction to 1.9 Å, space group C2) Acta crystallographica. Section F, Structural biology and crystallization communications Medium 22102035
2013 PSPC1 is part of a transcriptional complex with LMX1B and PSF (SFPQ) in dopaminergic cells; PSPC1 was identified as a binding partner of LMX1B by affinity purification/mass spectrometry and confirmed by co-immunoprecipitation in vitro and in vivo. Affinity purification of LMX1B-HIS followed by mass spectrometry; co-immunoprecipitation in vitro and in vivo PloS one Medium 23308148
2014 PSPC1 is required for the G1/S DNA damage checkpoint: knockdown of PSPC1 in HeLa cells caused cells to escape cisplatin-induced G1/S arrest and enter mitosis, leading to increased cell death. PSPC1 did not co-localize with γH2AX, 53BP1, or Rad51, indicating it does not directly participate in those DNA repair pathways. siRNA knockdown, cell cycle analysis by flow cytometry, γH2AX/53BP1/Rad51 co-localization by immunofluorescence, cisplatin treatment PloS one Medium 24819514
2014 PSPC1 functionally compensates for NONO in DNA double-strand break (DSB) repair: in NONO-knockout MEFs, PSPC1 is upregulated and replaces NONO in a stable complex with SFPQ. Dual knockdown of NONO and PSPC1 causes severe radiosensitivity and delayed DSB repair focus resolution. Epistasis with DNA-PK inhibitor NU7741 places NONO/PSPC1 in the same DSB repair pathway as DNA-PK. Knockout mouse-derived MEFs, siRNA knockdown, clonogenic radiosensitivity assay, γH2AX foci resolution, DNA-PK inhibitor epistasis, co-immunoprecipitation Nucleic acids research High 25100870
2017 PSPC1 binds intronic and 3'-UTR regions of adipocyte RNAs (including EBF1 mRNA) via CLIP-seq; it associates with the RNA export factor DDX3X in a differentiation-dependent manner. During adipogenesis, PSPC1 relocates from the nucleus to the cytoplasm, coinciding with enhanced nuclear export of adipogenic RNAs. PSPC1 knockout in fat reduces lipid storage and confers resistance to diet-induced obesity. CLIP-seq, paraspeckle complex purification from adipocytes, co-immunoprecipitation with DDX3X, subcellular fractionation/live imaging, adipose-specific knockout mouse The Journal of clinical investigation High 28192372
2017 NONO and PSPC1 synergistically activate transcription of Aldh1a1 in Sertoli cells by binding to a specific CCGGAGTC sequence in the Aldh1a1 promoter, protecting cells against MEHP-induced oxidative stress. siRNA knockdown of NONO and PSPC1, promoter-binding assay, gene expression analysis, oxidative stress assay FEBS letters Medium 28117896
2018 PSPC1 interacts with phosphorylated nuclear Smad2/3 to potentiate TGF-β1 autocrine signalling, increasing TGF-β1 secretion. PSPC1 acts as a contextual determinant of Smad2/3 binding preference, switching Smad2/3 from tumour-suppressor to pro-metastatic target genes, thereby driving EMT, stemness, and metastasis. Co-immunoprecipitation of PSPC1 with pSmad2/3, TGF-β1 ELISA, ChIP-seq for Smad2/3 binding, spontaneous mouse cancer models, multiple cancer cell lines Nature cell biology High 29593326
2018 Crystal structure of the SFPQ/PSPC1 heterodimer resolved to 2.3 Å reveals that SFPQ-containing heterodimers dissociate at low micromolar concentrations and that SFPQ/PSPC1 heterodimer has >6-fold higher affinity than SFPQ/NONO heterodimer, providing a structural mechanism for preferential PSPC1–SFPQ heterodimerization over SFPQ homodimerization. X-ray crystallography (2.3 Å resolution), analytical ultracentrifugation The Journal of biological chemistry High 29530979
2018 PSPC1 (PSP1/p54nrb) is required for HDV replication in HEK-293 cells; HDV replication induces delocalization of PSP1 from paraspeckles to cytoplasmic foci containing PABP and increases NEAT1 levels, causing paraspeckle enlargement. RNAi-mediated knockdown in HDV-replicating HEK-293 cells, immunofluorescence for PSP1 localization, NEAT1 level quantification Scientific reports Medium 29662142
2019 PSPC1 is a nuclear substrate of PTK6; when PSPC1 sequesters PTK6 in the nucleus, PTK6 acts as a tumour suppressor. PSPC1 overexpression or Y523F mutation promotes cytoplasmic translocation of active PTK6 and nuclear translocation of β-catenin, which interacts with PSPC1 to augment Wnt3a autocrine signalling and drive EMT and metastasis. Expression of PSPC1-CT131 (C-terminal 131 aa) reverses these translocations and suppresses metastasis. Co-immunoprecipitation, subcellular fractionation, site-directed mutagenesis (Y523F), HCC orthotopic mouse model, PSPC1-CT131 peptide expression Nature communications High 31844057
2020 PSPC1 overexpression induces focal adhesion formation and activates FAK/Src signalling to enhance cell adhesion and motility. PSPC1 transcriptionally upregulates IGF1R, which mediates focal adhesion pathway activation. Knockdown of paraspeckle components NONO, FUS, and NEAT1 lncRNA abolishes PSPC1-activated IGF1R expression. Phospho-kinase antibody array, RNA-seq transcriptome analysis, protein pulldown proteomics, IGF1R siRNA/inhibitor treatment, NONO/FUS/NEAT1 siRNA knockdown Cells Medium 32570949
2021 PSPC1 interacts with phosphatase PPP5C (PP5), and through this interaction regulates CHK1 phosphorylation. PSPC1 undergoes liquid-liquid phase separation via its prion-like domain (PrLD); deletion of PrLD abolishes phase separation and abrogates PSPC1's ability to regulate CHK1 phosphorylation, impairing mouse oocyte maturation. Co-immunoprecipitation (PSPC1–PPP5C), Western blot for CHK1 phosphorylation, PrLD deletion mutant analysis, in vitro phase separation assay, mouse oocyte maturation assay with knockdown Acta biochimica et biophysica Sinica Medium 34490876
2022 Crystal structures of the human NONO and PSPC1 homodimers were determined, revealing conserved contacts and structural plasticity at the dimerization interface that explain dimer selectivity among DBHS paralogs. Solution X-ray scattering showed that nucleic acid binding is reliant on RRM1 of NONO, and a newly identified 'β-clasp' structure influences RRM1 orientation for cooperative RNA recognition. X-ray crystallography (NONO and PSPC1 homodimers), small-angle X-ray scattering (SAXS), biochemical nucleic acid binding experiments Nucleic acids research High 34904671
2022 PSPC1 interacts with TET1 in embryonic stem cells and functionally associates with Polycomb repressive complex-2 (PRC2) at bivalent gene promoters; PSPC1 and TET1 repress bivalent gene expression, and during ESC-to-EpiLC transition they maintain PRC2 chromatin occupancy at bivalent promoters. Proteomics-based TET1 interactome mapping, genome-wide ChIP-seq for PSPC1, TET1, and PRC2, loss-of-function experiments in ESCs Cell reports Medium 35675764
2023 PSPC1 is a regulatory subunit of the m6A demethylase ALKBH5, preferentially interacting with K235-acetylated ALKBH5 (acetylated by KAT8, deacetylated by HDAC7) to recruit m6A-modified mRNA and facilitate m6A erasure, thereby promoting tumorigenesis. Co-immunoprecipitation of PSPC1 with acetylated ALKBH5, m6A demethylation activity assays, site-directed mutagenesis at K235, KAT8/HDAC7 writer/eraser identification Nature communications High 37369679
2024 SKP2 stabilizes PSPC1 by preventing TRIM21-mediated polyubiquitination and proteasomal degradation of PSPC1; SKP2 depletion results in PSPC1 polyubiquitination and degradation, and the SKP2/PSPC1 axis promotes PDAC cell migration. Co-immunoprecipitation, ubiquitination assays, SKP2 depletion by siRNA, SMIP004 (SKP2 inhibitor) treatment, migration assays Cancer letters Medium 38360141
2024 PSPC1 binds directly to the SLIV region of the HCV IRES upon HCV infection, competing with ribosomal protein RPS5 for IRES binding; PSPC1 binding prevents ribosomal loading and inhibits HCV RNA translation. Partial silencing of PSPC1 increases HCV RNA in polysomes and enhances viral replication. Competition UV-crosslinking experiments, PSPC1 partial silencing (siRNA), polysome profiling, immunoprecipitation assays Viruses Medium 38793620
2025 PSPC1 co-occupies chromatin with the transcription factor PU.1 in AML cells, activating a unique leukemic transcription program including NDC1. PSPC1 loss induces myeloid differentiation and abolishes leukemogenesis; PSPC1 is not required for normal hematopoiesis. ChIP-seq for cooperative chromatin binding of PSPC1 and PU.1, PSPC1 knockout/knockdown in human AML cells and mouse models, differentiation and proliferation assays Cell stem cell High 39954676
2025 PSPC1 interacts with SMAD3 and promotes its phosphorylation; iron-induced downregulation of PSPC1 alleviates SMAD3-mediated repression of thermogenic genes, thereby inducing beiging of white adipocytes. Overexpression of PSPC1 in subcutaneous adipose tissue reverses iron-induced beiging. Co-immunoprecipitation of PSPC1 with SMAD3, RNA-seq and ATAC-seq in adipocytes, PSPC1 overexpression in vivo (subcutaneous adipose tissue), Western blot for SMAD3 phosphorylation Cell communication and signaling : CCS Medium 41345872
2025 NONO, SFPQ, and PSPC1 associate with catalytically active telomerase through the hTR RNA component. Depletion of PSPC1 (and NONO) causes telomerase retention in Cajal bodies, impairs telomerase recruitment to telomeres, and leads to progressive telomere shortening. Co-immunoprecipitation of DBHS proteins with telomerase/hTR, immunofluorescence for Cajal body retention, telomere length measurement upon PSPC1/NONO depletion in multiple cell lines Nature communications High 40593584
2025 PSPC1 interacts with PARP1, competitively inhibiting PARP1-mediated PARylation and dephosphorylation of STAT3, thereby sustaining STAT3 activation and promoting CCL2 transcription and M2 macrophage polarization. Co-immunoprecipitation of PSPC1 with PARP1, STAT3 phosphorylation assays, CCL2 secretion measurement, macrophage polarization co-culture assay Oncogene Medium 41986651
2025 Etoposide-induced DNA double-strand breaks do not substantially alter the NONO–SFPQ or NONO–PSPC1 protein-protein interactions, indicating that DBHS family members promote genome stability as constitutively stable dimers rather than dynamically assembling upon DNA damage. Label-free mass spectrometry interactome profiling of NONO in U2OS cells ± etoposide, orthogonal co-immunoprecipitation, co-localization assays bioRxivpreprint Medium

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold. Nucleic acids research 271 27084935
2005 P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner. Molecular biology of the cell 198 16148043
2018 PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis. Nature cell biology 166 29593326
2006 PSPC1, NONO, and SFPQ are expressed in mouse Sertoli cells and may function as coregulators of androgen receptor-mediated transcription. Biology of reproduction 79 16641145
2014 Double-strand break repair deficiency in NONO knockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog. Nucleic acids research 59 25100870
2023 K235 acetylation couples with PSPC1 to regulate the m6A demethylation activity of ALKBH5 and tumorigenesis. Nature communications 42 37369679
2017 RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. The Journal of clinical investigation 42 28192372
2019 PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression. Nature communications 40 31844057
2018 Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins. The Journal of biological chemistry 37 29530979
2022 Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1. Nucleic acids research 29 34904671
2018 The Hepatitis Delta Virus accumulation requires paraspeckle components and affects NEAT1 level and PSP1 localization. Scientific reports 28 29662142
2016 FTIR imaging of the molecular burden around Aβ deposits in an early-stage 3-Tg-APP-PSP1-TAU mouse model of Alzheimer's disease. The Analyst 22 27917428
2022 A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency. Cell reports 21 35675764
1997 A novel protein, Psp1, essential for cell cycle progression of Schizosaccharomyces pombe is phosphorylated by Cdc2-Cdc13 upon entry into G0-like stationary phase of cell growth. The Journal of biological chemistry 21 9242669
2024 SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation. Cancer letters 20 38360141
2013 LMX1B is part of a transcriptional complex with PSPC1 and PSF. PloS one 18 23308148
2011 Construct optimization for studying protein complexes: obtaining diffraction-quality crystals of the pseudosymmetric PSPC1-NONO heterodimer. Acta crystallographica. Section D, Biological crystallography 18 22101825
2014 Paraspeckle protein 1 (PSPC1) is involved in the cisplatin induced DNA damage response--role in G1/S checkpoint. PloS one 17 24819514
2015 Advantages of the phosphatidylserine-recognizing peptide PSP1 for molecular imaging of tumor apoptosis compared with annexin V. PloS one 15 25803297
2020 PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility. Cells 14 32570949
2011 Crystallization of a paraspeckle protein PSPC1-NONO heterodimer. Acta crystallographica. Section F, Structural biology and crystallization communications 14 22102035
2021 PSPC1 regulates CHK1 phosphorylation through phase separation and participates in mouse oocyte maturation. Acta biochimica et biophysica Sinica 13 34490876
2021 Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells. Molecular carcinogenesis 12 34699643
2023 LncRNA LOC105369504 inhibits tumor proliferation and metastasis in colorectal cancer by regulating PSPC1. Cell death discovery 11 36894530
2025 PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1. Cell stem cell 10 39954676
2018 Development of PSP1, a Biostimulant Based on the Elicitor AsES for Disease Management in Monocot and Dicot Crops. Frontiers in plant science 10 30087681
2020 PSPC1: a contextual determinant of tumor progression. Molecular & cellular oncology 9 32158931
2021 PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression. Journal of biomedical science 8 34340703
2018 PSP1, a Phosphatidylserine-Recognizing Peptide, Is Useful for Visualizing Radiation-Induced Apoptosis in Colorectal Cancer In Vitro and In Vivo. Translational oncology 8 29982102
2023 PSPC1 Inhibition Synergizes with Poly(ADP-ribose) Polymerase Inhibitors in a Preclinical Model of BRCA-Mutated Breast/Ovarian Cancer. International journal of molecular sciences 6 38069409
2017 Synergistic upregulation of NONO and PSPC1 regulates Sertoli cell response to MEHP via modulation of ALDH1A1 signaling. FEBS letters 5 28117896
2013 Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase. Yeast (Chichester, England) 5 23640764
2023 A Putative New Role of Tv-PSP1 Recognizes IRE and ERE Hairpin Structures from Trichomonas vaginalis. Pathogens (Basel, Switzerland) 4 36678426
2025 NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere. Nature communications 3 40593584
2024 Evaluation of PSP1 biostimulant on Fusarium graminearum-wheat pathosystem: impact on disease parameters, grain yield, and grain quality. Pest management science 3 38450978
2025 Regulation of the mechanoresponsive Neat1 and PSPC1 by substrate stiffness in TGF-β1-induced renal progenitor cell fate. Journal of biomedical science 2 41243096
2025 PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia. Cell stem cell 1 40054451
2025 PSPC1 knockout promotes radiosensitivity, inhibits EMT, and metastasis of nasopharyngeal carcinoma cells. Experimental cell research 1 40962170
2025 LncRNA CASC19 promotes pancreatic cancer progression by increasing PSPC1 protein stability and facilitating the oncogenic PSPC1/ β-Catenin pathway. Molecular medicine (Cambridge, Mass.) 1 41023804
2024 PSPC1 Binds to HCV IRES and Prevents Ribosomal Protein S5 Binding, Inhibiting Viral RNA Translation. Viruses 1 38793620
2022 Biodesulfurization of thiosulfate by a Pseudomonas strain PSP1 and the investigation of underlying metabolic mechanisms. Environmental science and pollution research international 1 35029825
2026 PSPC1-AS2/PSPC1 axis drives STAT3-dependent CCL2 expression to promote M2 macrophage polarization and liver metastasis in gastric cancer. Oncogene 0 41986651
2026 Timing-dependent responses of Fusarium graminearum suppression and malting quality in barley following PSP1 elicitor application. Frontiers in plant science 0 42206151
2025 M6A-METTL3-dependent nuclear PANC754/PSPC1/H3K4me1 repression complex regulate immune evasive LGALS7 signal to enhance immunotherapy against colorectal cancer. Cell death & disease 0 40634299
2025 PSPC1-SMAD3 axis regulates iron-induced beiging of adipocytes in white adipose tissue. Cell communication and signaling : CCS 0 41345872

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