Affinage

EIF4B

Eukaryotic translation initiation factor 4B · UniProt P23588

Length
611 aa
Mass
69.2 kDa
Annotated
2026-06-09
86 papers in source corpus 36 papers cited in narrative 36 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 4/4 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

eIF4B is a multi-domain translation initiation cofactor that stimulates the DEAD-box helicase eIF4A to unwind structured 5' UTRs and promote mRNA recruitment, scanning, and 40S subunit engagement (PMID:11418588, PMID:24848014, PMID:10801326). Mechanistically, eIF4B raises the ATP-binding affinity of eIF4A ~10-fold and selectively accelerates the closing rate of the eIF4A conformational cycle, rendering the helicase processive; eIF4G acts synergistically by promoting the closed conformer, and eIF4B can also act upstream of eIF4A recruitment to favor productive eIF4F assembly (PMID:24848014, PMID:24080224, PMID:23184954, PMID:10801326). eIF4B is built from functionally separable modules: an RNA-binding region and RRM that cooperate with eIF4A (PMID:8139536, PMID:9769100), a 7-repeat domain that directly binds eIF4A and contacts the 40S head via Rps20 to reshape the mRNA entry channel (PMID:23236192, PMID:27858515), and a DRYG domain that mediates self-association and direct binding to the eIF3 p170 subunit, bridging mRNA to the ribosome (PMID:8816444). The protein also binds the m7G cap and PABP, coupling 5' cap and poly(A) functions and enhancing initiation-complex helicase and scanning activity (PMID:9195926, PMID:3395129, PMID:10748132), and catalyzes RNA strand annealing/exchange (PMID:7543843, PMID:9769100). Beyond a global eIF4A-dependent role, eIF4B independently supports translation of a distinct set of long, structured-5'UTR mRNAs and contributes to translation termination by loading eRF1 into the A site within a closed-loop mRNP (PMID:27601676, PMID:40066881). eIF4B activity is tuned by phosphorylation at multiple sites — S6K1 and RSK at Ser422 (downstream of mTORC1/PI3K and MAPK, requiring PDK1), Pim and MELK at Ser406, casein kinase 2 at Ser504, and ERK2 at Ser93 — which collectively increase eIF4B association with eIF3 and recruitment to pre-initiation complexes, while PP2A dephosphorylation at Ser406 reverses this (PMID:16763566, PMID:27528663, PMID:23749639, PMID:25332164, PMID:28874824, PMID:41490890), and its protein level is set by opposing USP11 deubiquitination and PARK2 ubiquitination under mTORC1 control (PMID:29483509, PMID:35105670). eIF4B is required for organismal viability and antiviral immunity, and its phospho-regulated translational output drives oncogenic programs including c-Myc/glutamine metabolism, mitotic MCL1 synthesis, and EMT-associated metastasis (PMID:25220053, PMID:27528663, PMID:34566982, PMID:41490890).

Mechanistic history

Synthesis pass · year-by-year structured walk · 35 steps
  1. 1988 Medium

    Establishing where eIF4B engages the mRNA was the first step in defining its initiation role; cap crosslinking placed it near the 5' terminus.

    Evidence UV crosslinking to cap-labeled mRNA with anti-eIF4B immunoprecipitation

    PMID:3395129

    Open questions at the time
    • Does not distinguish direct cap recognition from positioning within eIF4F
    • Single study, no domain mapping of the cap contact
  2. 1990 Medium

    eIF4B was identified as a regulated phosphoprotein, linking translation initiation to upstream signaling before specific kinases were known.

    Evidence 2D phosphopeptide mapping and 32P-labeling in 3T3-L1 cells with insulin and PMA

    PMID:2191953

    Open questions at the time
    • Did not identify specific phosphosites or kinases
    • Functional consequence of phosphorylation not established
  3. 1991 High

    Resolving how eIF4B contributes to helicase action showed it forms a distinct, processive helicase intermediate with eIF4F prior to ribosome binding.

    Evidence Gel mobility shift plus ATP-dependent RNA unwinding assays with purified factors

    PMID:1719376

    Open questions at the time
    • Did not define which eIF4B domains mediate complex formation
    • Stoichiometry within the helicase intermediate not resolved
  4. 1994 High

    Domain dissection clarified that a discrete RNA-binding region, separate from the RRM, drives cooperation with eIF4A in helicase stimulation.

    Evidence Deletion and point mutagenesis in COS cells with in vitro RNA-binding and helicase stimulation assays

    PMID:8139536

    Open questions at the time
    • Did not assign these domains to ribosome contacts
    • Structural basis of RRM contribution to helicase stimulation unresolved
  5. 1995 High

    Discovery of RNA strand-annealing activity revealed an eIF4B function beyond helicase co-stimulation, conserved from yeast to mammals.

    Evidence In vitro RNA annealing with recombinant Tif3 and Tif3-dependent yeast translation system

    PMID:7543843

    Open questions at the time
    • Physiological role of annealing during initiation unclear
    • Site/domain responsible not mapped in this study
  6. 1996 High

    Identification of the DRYG domain explained how eIF4B self-associates and bridges mRNA to the 40S subunit through eIF3.

    Evidence Far Western and yeast two-hybrid with domain deletion in vitro and in vivo

    PMID:8816444

    Open questions at the time
    • Functional consequence of self-association not established
    • eIF3-p170 contact residues not resolved
  7. 1997 High

    eIF4B–PABP interaction provided a molecular basis for 5' cap and poly(A) functional co-dependence.

    Evidence Far Western, fluorescence titration, and RNA mobility shift with plant eIF4B and PABP

    PMID:9195926

    Open questions at the time
    • Shown in plant system; mammalian relevance not directly tested here
    • In vivo consequence on closed-loop formation not measured
  8. 1998 High

    Systematic domain mapping in yeast tied the RRM and 7-repeat region to RNA binding, strand exchange, translation, and viability.

    Evidence Deletion analysis with in vivo complementation and in vitro RNA-binding/strand-exchange assays in Tif3

    PMID:9769100

    Open questions at the time
    • Did not resolve which activities are essential in vivo
    • Structural arrangement of multiple RNA-binding modules unknown
  9. 2000 High

    Mechanistic dissection showed eIF4B stimulates eIF4A by increasing its ATP-binding affinity, enabling the conformational cycling needed for processivity.

    Evidence Direct fluorescence ATP/ADP binding, ATPase, and helicase assays with wheat germ factors

    PMID:10801326

    Open questions at the time
    • Plant factors; conformational step not directly observed
    • Did not address eIF4G synergy
  10. 2000 Medium

    PABP was shown to enhance the ATPase/helicase output and scanning rate of the eIF4A–eIF4B–eIF4F complex, integrating poly(A) into initiation kinetics.

    Evidence ATPase kinetic and duplex unwinding assays with combinations of purified wheat germ factors

    PMID:10748132

    Open questions at the time
    • Plant system, single lab
    • Direct eIF4B–PABP versus eIF-iso4G contributions not separated
  11. 2001 High

    Quantitative helicase kinetics established that eIF4B raises both rate and amplitude of eIF4A unwinding and confers limited processivity, with effects scaling to substrate features.

    Evidence In vitro helicase assays with chemically modified duplex substrates and kinetic analysis

    PMID:11418588

    Open questions at the time
    • Conformational mechanism not yet resolved
    • Did not test ribosomal context
  12. 2006 High

    This work integrated eIF4B into two converging signaling arms, showing S6K1 and RSK phosphorylate Ser422 to increase eIF3 binding, with PDK1 required for both.

    Evidence In-cell phosphorylation, rapamycin treatment, PDK1-null ES cells, and eIF4B–eIF3 Co-IP

    PMID:16763566

    Open questions at the time
    • Structural basis for phospho-enhanced eIF3 binding unknown
    • Did not measure mRNA-selective translational output
  13. 2008 High

    Footprinting revealed eIF4B and eIF4H share a mutually exclusive eIF4A site and extend the RNA footprint, defining how accessory factors enlarge eIF4A's RNA engagement.

    Evidence Gel shift/RNase protection footprinting with competition and stoichiometry analysis

    PMID:18719248

    Open questions at the time
    • Did not localize the shared site on eIF4A structurally
    • Functional consequence of extended footprint on scanning unmeasured
  14. 2010 High

    Genetic and biochemical evidence placed eIF4B upstream of eIF4A in eIF4F assembly, promoting an eIF4G conformation conducive to eIF4A binding.

    Evidence Yeast suppressor screen of eIF4G HEAT mutants, in vivo Co-IP, and in vitro complex reconstitution

    PMID:23184954

    Open questions at the time
    • Mechanism of eIF4G conformational priming not structurally defined
    • Mammalian conservation of pre-eIF4A complex not shown
  15. 2012 High

    p70S6K1 phosphorylation of eIF4B (with PDCD4) was shown to be required for global protein synthesis independent of 4E-BP control, decoupling eIF4B regulation from cap-binding regulation.

    Evidence 4E-BP1/2 double-knockout MEFs, mTORC1 inhibition, polysome and 35S-methionine assays with eIF4B knockdown

    PMID:23105104

    Open questions at the time
    • Did not identify the specific mRNAs most dependent on eIF4B phosphorylation
    • Relative contribution of eIF4B versus PDCD4 not separated
  16. 2012 High

    Ribosome-level work defined how eIF4B engages the ribosome, binding the 40S head via Rps20 to remodel the mRNA entry channel and promote eIF4A action on the PIC.

    Evidence Yeast domain deletions in vitro/in vivo, ribosome binding, structural probing, and mRNA recruitment assays

    PMID:23236192

    Open questions at the time
    • High-resolution structure of the eIF4B–40S contact lacking
    • RRM role on the ribosome remained ambiguous
  17. 2013 High

    Pim-1/2 kinases were identified as direct Ser406/Ser422 kinases whose eIF4B phosphorylation drives Abl-oncogene transformation and survival.

    Evidence In vitro kinase assays, Pim inhibitors, siRNA, phosphomimetics, xenografts, and eIF4B-knockdown mice

    PMID:23749639

    Open questions at the time
    • Mechanistic link between phospho-eIF4B and specific oncogenic mRNAs not detailed here
    • Site-specific contributions of S406 versus S422 not fully separated
  18. 2013 High

    Conformational assays showed eIF4B and eIF4G cooperate to favor the closed eIF4A conformer, with eIF4G first observed to drive closure.

    Evidence FRET conformational, ATPase, and helicase assays with purified yeast factors

    PMID:24080224

    Open questions at the time
    • eIF4B alone did not alter conformation, leaving its independent step undefined
    • Did not resolve order of factor binding
  19. 2014 High

    Single-step kinetics refined the model: eIF4B selectively accelerates eIF4A closing in an ssRNA-dependent manner, synergizing with eIF4G.

    Evidence FRET open/closed assays plus ATPase and unwinding assays with purified factors

    PMID:24848014

    Open questions at the time
    • Structural state of the closed eIF4A–eIF4B complex unresolved
    • Coupling to 40S scanning not directly observed
  20. 2014 High

    eIF4B phosphorylation was linked to selective translation of structured c-Myc mRNA, connecting mTORC1/S6K1 signaling to glutamine metabolism via GLS.

    Evidence Ribosome profiling, eIF4B knockdown/rescue, phosphomutants, polysome profiling, Myc-5'UTR reporters

    PMID:25220053

    Open questions at the time
    • Generality of structured-5'UTR selectivity beyond Myc not defined
    • Direct eIF4B occupancy on Myc mRNA not shown
  21. 2014 Medium

    A repressive layer was revealed: BC RNAs sequester eIF4B until PP2A dephosphorylation of Ser406 releases it to engage the 40S in neurons.

    Evidence BC RNA–eIF4B Co-IP, phospho-assays, PP2A manipulation, and neuronal in vitro translation

    PMID:25332164

    Open questions at the time
    • Single lab; reciprocal validation of BC RNA binding limited
    • Quantitative coupling between dephosphorylation and 40S engagement incomplete
  22. 2016 High

    Ribosome profiling in yeast established an eIF4A-independent function of eIF4B on a distinct set of long structured mRNAs.

    Evidence Comparative ribosome profiling of eIF4B and eIF4A/Ded1 loss-of-function mutants

    PMID:27601676

    Open questions at the time
    • Molecular basis of the eIF4A-independent activity unidentified
    • Whether annealing or 40S contact underlies it not resolved
  23. 2016 High

    Domain-resolved reconstitution assigned eIF4A stimulation to the 7-repeat region, which binds eIF4A and reshapes its conformational landscape independent of eIF4G.

    Evidence In vitro binding, FRET, ATPase, and helicase assays with isolated eIF4B domain constructs

    PMID:27858515

    Open questions at the time
    • Structure of the 7-repeat–eIF4A interface lacking
    • Contribution of other domains to in-cell stimulation not addressed
  24. 2016 High

    MELK was identified as a mitosis-specific Ser406 kinase whose eIF4B phosphorylation supports MCL1 synthesis and cancer cell survival during division.

    Evidence IP/MS substrate identification, peptide profiling, phospho-assays, knockdown, and apoptosis readouts

    PMID:27528663

    Open questions at the time
    • Mechanism by which mitotic eIF4B selects MCL1 mRNA not defined
    • Overlap with Pim-mediated Ser406 control not delineated
  25. 2017 Medium

    CK2 phosphorylation at Ser504 was shown to enhance PIC recruitment and synaptic localization, expanding the phospho-site map controlling eIF4B engagement.

    Evidence Phospho-specific antibody, Co-IP, fractionation, synaptic imaging, and CK/mGluR manipulation

    PMID:28874824

    Open questions at the time
    • Single lab; direct PIC occupancy quantification limited
    • Causal link from Ser504 to PKMζ output indirect
  26. 2018 Medium

    eIF4B protein stability emerged as a regulatory node, with USP11 deubiquitinating and stabilizing eIF4B downstream of FASN/PI3K-S6K signaling in lymphoma.

    Evidence Co-IP/MS, pharmacological inhibition, and knockdown/rescue in DLBCL cells

    PMID:29483509

    Open questions at the time
    • Single lab; reciprocal validation of the USP11–eIF4B interaction limited
    • Ubiquitin sites on eIF4B not mapped here
  27. 2019 Medium

    A FLT3-ITD/RSK1 axis was placed upstream of eIF4B, with cooperative S422/S406 phosphorylation enhancing cap-dependent translation and AML survival.

    Evidence Kinase inhibitors, phospho-Western, and knockdown in AML cell models

    PMID:31756944

    Open questions at the time
    • Single lab; direct kinase assay for RSK1 on eIF4B not in this study
    • mRNA targets of activated eIF4B in AML not defined
  28. 2019 Medium

    A Drosophila screen implicated eIF4B in RAN-translation of toxic GR dipeptides from C9orf72 G4C2 repeats, linking it to ALS/FTD pathology.

    Evidence Loss-of-function genetic screen, GR-GFP reporter, eye toxicity, and patient tissue validation

    PMID:31023341

    Open questions at the time
    • Direct eIF4B action on repeat RNA not biochemically reconstituted
    • Mechanism distinguishing RAN from canonical initiation unclear
  29. 2021 High

    Knockout mice established that eIF4B is required for viability and antiviral immunity and that its loss derepresses mTOR feedback signaling.

    Evidence Constitutive and conditional knockout mice with histopathology, apoptosis, mTOR-pathway blots, and influenza infection

    PMID:34566982

    Open questions at the time
    • Cell-autonomous versus systemic contributions to viral susceptibility not dissected
    • Mechanism of enhanced mTOR signaling upon eIF4B loss unresolved
  30. 2021 Medium

    CK2-dependent eIF4B phosphorylation was tied to BACE1 translation and APP processing, elevated in Alzheimer's models, implicating eIF4B in disease-relevant neuronal translation.

    Evidence CK2 inhibition, eIF4B knockdown/rescue, organotypic slices, AD mouse models, and translation reporters

    PMID:34349120

    Open questions at the time
    • Single lab; causal contribution to AD pathogenesis not established
    • Direct eIF4B occupancy on BACE1 mRNA not shown
  31. 2022 Medium

    PARK2 was identified as an eIF4B E3 ligase whose mTORC1-controlled inhibition (Ser127 phosphorylation) stabilizes eIF4B to drive lymphoma translation, completing a stability-control circuit with USP11.

    Evidence Co-IP, ubiquitination assays, mutational analysis, and mTORC1 inhibition in DLBCL models

    PMID:35105670

    Open questions at the time
    • Single lab; ubiquitin acceptor sites on eIF4B not mapped
    • Interplay with USP11 not directly co-tested
  32. 2024 Medium

    Biophysical characterization showed the eIF4B IDR self-associates into dynamic oligomers preceding phase separation, sensitive to ionic strength and crowding.

    Evidence Single-molecule spectroscopy and molecular simulations with environmental perturbations

    PMID:39384813

    Open questions at the time
    • Functional role of phase separation in translation untested
    • Regulation by specific PTMs/partners inferred, not demonstrated
  33. 2025 High

    Reconstitution extended eIF4B function to termination, where it (with eIF4A) loads eRF1 into the A site within a closed-loop mRNP.

    Evidence Reconstituted mammalian termination system, eIF4G domain mapping, eRF3 GTPase and peptide-release assays

    PMID:40066881

    Open questions at the time
    • In vivo importance of eIF4B in termination not established
    • Structural basis of eRF1 loading by eIF4B/eIF4A lacking
  34. 2025 Medium

    Pathogenic tau was shown to sequester eIF4B from the initiation complex, blocking dendritic local translation and plasticity, with rescue by restoring eIF4B.

    Evidence Tau–eIF4B Co-IP, translatomics, dendritic imaging, and rescue in FTLD-tau neurons (preprint)

    PMID:41279029

    Open questions at the time
    • Preprint, not yet peer-reviewed
    • Direct interaction interface and stoichiometry not defined
  35. 2026 Medium

    ERK2 was identified as a Ser93 kinase that stabilizes and activates eIF4B to promote EMT-marker translation and colorectal cancer metastasis.

    Evidence Phosphoproteomics, in vitro ERK2 kinase assay, ubiquitination assays, and CRC models in vitro/in vivo

    PMID:41490890

    Open questions at the time
    • Single lab; how Ser93 phosphorylation reduces ubiquitination mechanistically unclear
    • Direct eIF4B targeting of mesenchymal mRNAs not shown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the many phosphosites, ubiquitin-stability circuits, and IDR self-association are integrated structurally to select specific mRNAs on the ribosome, and the in vivo significance of eIF4B's termination and phase-separation activities, remain unresolved.
  • No high-resolution structure of eIF4B bound to 40S/eIF4A
  • mRNA selection rules for phospho-activated eIF4B undefined
  • Physiological roles of termination and condensate behavior untested in vivo

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 6 GO:0098772 molecular function regulator activity 4 GO:0045182 translation regulator activity 3 GO:0060090 molecular adaptor activity 2 GO:0140098 catalytic activity, acting on RNA 2
Localization
GO:0005829 cytosol 1 GO:0005840 ribosome 1
Pathway
R-HSA-1643685 Disease 5 R-HSA-162582 Signal Transduction 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-168256 Immune System 2
Partners
EIF3 (P170/EIF3C)EIF4AEIF4G1EIF4HPABPPARK2RPS20USP11
Complex memberships
43S/48S pre-initiation complexeIF4F

Evidence

Reading pass · 36 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 S6K1 (downstream of mTORC1/PI3K) and RSK (downstream of MAPK) both phosphorylate eIF4B on Ser422; phosphorylation of eIF4B Ser422 by both kinases increases its interaction with eIF3. PDK1 is required for both kinases to activate and phosphorylate eIF4B Ser422. In-cell phosphorylation assays, rapamycin treatment, PDK1 null ES cells, Co-immunoprecipitation of eIF4B with eIF3 The EMBO journal High 16763566
2001 eIF4B stimulates both the initial rate and amplitude of eIF4A-dependent RNA duplex unwinding (helicase activity), making eIF4A slightly processive; stimulation magnitude depends on duplex stability and single-stranded flanking region length. In vitro RNA helicase unwinding assays with purified factors, kinetic analysis, chemically modified duplex substrates The Journal of biological chemistry High 11418588
1996 A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG domain) mediates eIF4B self-association and direct interaction with the p170 subunit of eIF3, positioning eIF4B as an intermediary between mRNA and the 40S ribosomal subunit via eIF3. Far Western (protein overlay) assay, yeast two-hybrid system, in vitro and in vivo domain deletion analysis Molecular and cellular biology High 8816444
1994 eIF4B contains an RNA-binding region (amino acids 367–423) that is the major contributor to RNA binding and is distinct from the RNP-CS/RRM; deletion of this region abolishes cooperation with eIF4A in RNA binding and stimulation of eIF4A helicase activity. Point mutations in the RNP-CS/RRM reduce helicase stimulation but not RNA binding cooperation with eIF4A. Deletion and point mutations expressed in COS cells; in vitro RNA binding assays; eIF4A helicase stimulation assay Molecular and cellular biology High 8139536
1995 Yeast eIF4B ortholog Tif3 (TIF3 gene product) and mammalian eIF4B both catalyze RNA strand annealing (RNA annealing activity) in vitro in addition to stimulating translation and mRNA–ribosome binding. Affinity-purified recombinant Tif3-His6p; in vitro RNA annealing assay; yeast Tif3-dependent in vitro translation system The EMBO journal High 7543843
2012 Yeast eIF4B (yeIF4B) binds to the head of the 40S ribosomal subunit via interaction with Rps20; the 7-repeat domain and N-terminal domain (not the RRM) are the critical functional domains; this interaction induces structural changes in the ribosomal mRNA entry channel and promotes productive eIF4A association with the 43S•mRNA PIC. Domain deletions tested in vitro and in vivo (yeast genetics); ribosome binding assays; structural probing of 40S changes; mRNA recruitment assays RNA (New York, N.Y.) High 23236192
2014 eIF4B selectively increases the closing rate of the eIF4A conformational cycle (transition to closed state), while eIF4G increases both closing and opening rates; together eIF4B and eIF4G synergistically accelerate the eIF4A conformational cycle and RNA unwinding; the effect of eIF4B on closing rate depends on the presence of single-stranded RNA regions. FRET-based conformational assay monitoring eIF4A open/closed states; ATPase assays; RNA unwinding assays with purified factors Nucleic acids research High 24848014
1991 eIF4F forms a stable complex (complex A) with duplex RNA in the absence of ATP; addition of eIF4B forms a slower-mobility complex (complex B); ATP-dependent unwinding occurs processively from these helicase complexes, indicating eIF4B participates in a processive helicase intermediate preceding ribosome binding. Gel mobility shift electrophoresis combined with RNA unwinding assays; ATP-dependent complex dissociation analysis Molecular and cellular biology High 1719376
1997 Plant eIF4B binds to poly(A)-binding protein (PABP) in the absence of poly(A) RNA and increases PABP RNA binding activity by shifting its equilibrium affinity for poly(A), suggesting a role for eIF4B in mediating functional co-dependence between the 5' cap and poly(A) tail during translation. Far Western analysis, direct fluorescence titration, RNA binding assays, RNA mobility shift analysis The Journal of biological chemistry High 9195926
2014 mTORC1/S6K1 signaling controls glutamine metabolism through eIF4B-dependent regulation of c-Myc translation: S6K1 phosphorylates eIF4B, which is required to unwind the structured 5' UTR of c-Myc mRNA and enhance its translation efficiency, thereby increasing GLS expression and glutamine flux. Ribosome profiling, eIF4B knockdown/rescue, phosphomimetic/phosphodeficient eIF4B mutants, polysome profiling, luciferase reporter with Myc 5'UTR Current biology : CB High 25220053
2016 eIF4B has an eIF4A-independent role in translation of long mRNAs with structured 5' UTRs; ribosome profiling of yeast eIF4B deletion mutants shows eIF4B loss impairs a broader set of mRNAs than eIF4A inactivation, with little overlap, demonstrating independent functions. Ribosome profiling of eIF4B deletion mutants and eIF4A/Ded1 loss-of-function mutants in yeast; comparative translational efficiency analysis Proceedings of the National Academy of Sciences of the United States of America High 27601676
2018 eIF4B is a substrate of the deubiquitinase USP11; USP11 stabilizes eIF4B protein and enhances its activity. FASN-induced PI3K-S6K signaling phosphorylates USP11, promoting its interaction with eIF4B and thereby sustaining oncogenic translation in DLBCL. Co-immunoprecipitation, mass spectrometry, pharmacological inhibition, genetic knockdown/rescue in DLBCL cells Nature communications Medium 29483509
2016 MELK kinase phosphorylates eIF4B at Ser406 during mitosis; this MELK-eIF4B signaling axis regulates protein synthesis specifically during mitosis, including synthesis of the antiapoptotic protein MCL1, thereby supporting cancer cell survival during cell division. Immunoprecipitation/mass spectrometry to identify eIF4B as MELK substrate; peptide library profiling; phospho-specific assays; MELK/eIF4B knockdown; MCL1 synthesis measurement; apoptosis assays Proceedings of the National Academy of Sciences of the United States of America High 27528663
2013 Pim-1 and Pim-2 kinases directly phosphorylate eIF4B on Ser406 and Ser422; this phosphorylation is critical for Abl oncogene-driven cellular transformation; expression of phosphomimetic eIF4B confers resistance to Pim inhibitor-induced apoptosis. In vitro kinase assays, pharmacological inhibition (SMI-4a, imatinib), siRNA knockdown, phosphomimetic mutants, tumor xenograft assays, eIF4B-knockdown transgenic mice Cancer research High 23749639
2012 p70S6K1-dependent phosphorylation of eIF4B (and PDCD4) is required for global protein synthesis downstream of mTORC1; maintenance of eIF4E–eIF4G interaction alone is insufficient to sustain global translation in the absence of mTORC1-p70S6K1 signaling to eIF4B. 4E-BP1/2 double-knockout MEFs; pharmacological mTORC1 inhibition; polysome analysis; 35S-methionine incorporation; eIF4B and PDCD4 knockdown The Journal of biological chemistry High 23105104
2014 Neuronal BC RNAs act as translational repressors by interacting with eIF4B; upon neuronal stimulation, protein phosphatase 2A (PP2A) dephosphorylates eIF4B at Ser406, reducing eIF4B–BC RNA binding affinity and enabling eIF4B to engage the 40S ribosomal subunit for translation initiation of structured mRNAs such as PKMζ. Co-immunoprecipitation of BC RNA with eIF4B; phospho-specific assays; PP2A pharmacological manipulation; in vitro translation assays; neuronal stimulation experiments The Journal of cell biology Medium 25332164
2017 Casein kinase-mediated phosphorylation of eIF4B at Ser504 increases its recruitment to the pre-initiation complex and influences its localization at synapses; Ser504 phosphorylation modulates translation of PKMζ mRNA and is regulated by metabotropic glutamate receptor activation. Phospho-specific antibody generation, co-immunoprecipitation, subcellular fractionation, synaptic localization imaging, pharmacological manipulation of casein kinases and mGluRs Scientific reports Medium 28874824
2021 Casein kinase 2 (CK2)-dependent phosphorylation of eIF4B controls BACE1 mRNA translation in neurons; neuronal activity promotes CK2-dependent eIF4B phosphorylation leading to increased BACE1 expression and APP processing, with eIF4B expression and phosphorylation elevated in AD mouse models and patient brains. CK2 inhibition, eIF4B knockdown/rescue, organotypic brain slices, AD mouse models (APPPS1, APP-KI), immunoblotting, translation reporter assays Cell death & disease Medium 34349120
1990 In 3T3-L1 cells, insulin and phorbol ester (PMA/protein kinase C activation) each stimulate phosphorylation of eIF4B, demonstrating that eIF4B is a downstream phosphorylation target of both insulin signaling and PKC pathways. 2D phosphopeptide mapping, 32P-labeling in intact cells, PMA-induced PKC downregulation to separate pathway contributions The Journal of biological chemistry Medium 2191953
2008 eIF4B and eIF4H share a common, mutually exclusive binding site on eIF4A; both require AMPPNP (non-hydrolyzable ATP analog) and RNA for stable complex formation with eIF4A; the eIF4A:eIF4B and eIF4A:eIF4H complexes prefer longer RNAs (~30–33 nt) for binding than eIF4A alone (~17 nt), suggesting accessory factors extend RNA affinity beyond the footprint. Gel shift/RNase protection footprinting; selective RNA binding experiments; stoichiometric analysis; competition assays RNA (New York, N.Y.) High 18719248
2013 Yeast eIF4B and eIF4G synergistically stimulate eIF4A RNA-dependent ATPase and RNA helicase activities; eIF4B alone does not alter eIF4A conformation, but eIF4G promotes a closed eIF4A conformation (observed for the first time) in the presence of ATP and RNA; together they jointly favor the closed eIF4A conformer. FRET-based conformational assays, ATPase assays, RNA helicase assays with purified yeast factors Journal of molecular biology High 24080224
2016 The 7-repeat (r1-7) region of eIF4B directly binds eIF4A in the presence of RNA and ADPNP (independent of eIF4G) and is responsible for stimulating eIF4A ATPase and RNA unwinding activities and modulating the eIF4A conformational energy landscape. In vitro binding assays with purified proteins, FRET conformational assays, ATPase assays, RNA helicase assays with isolated domain constructs RNA biology High 27858515
2010 eIF4B overexpression enhances eIF4A–eIF4G complex (eIF4F) assembly in vivo in yeast; yeIF4B promotes a conformation of the eIF4G HEAT domain conducive to stable eIF4A binding; native complexes containing eIF4G and yeIF4B but lacking eIF4A were detected, suggesting yeIF4B acts prior to eIF4A recruitment. Genetic suppressor screen (Ts- eIF4G HEAT mutations suppressed by yeIF4B overexpression), in vivo co-immunoprecipitation, in vitro reconstitution of eIF4A·eIF4G complexes The Journal of biological chemistry High 23184954
1988 eIF4B is the 80-kDa protein that crosslinks to the m7G cap structure of eukaryotic mRNAs, demonstrating direct binding of eIF4B near the 5'-terminus of mRNA. UV crosslinking of eIF4B to cap-labeled mRNA; immunoprecipitation with polyclonal anti-eIF4B antibody Archives of biochemistry and biophysics Medium 3395129
2022 PARK2 (Parkin E3 ubiquitin ligase) ubiquitinates eIF4B, leading to its degradation and reduced protein translation. mTORC1 phosphorylates PARK2 at Ser127, blocking its ubiquitin ligase activity toward eIF4B, thereby stabilizing eIF4B and driving enhanced translation in lymphoma cells. Co-IP, mutational analysis, cellular ubiquitination assays, mTORC1 inhibition, biochemical and genetic studies in DLBCL models Molecular cancer research : MCR Medium 35105670
2021 eIF4B knockout in mice causes embryonic lethality with severe fetal liver damage and enhanced apoptosis; conditional knockout in adults increases mortality and susceptibility to viral infection. eIF4B-deficient mouse embryonic fibroblasts show excessive mTOR signaling activation (elevated p70S6K and 4EBP1 phosphorylation), indicating eIF4B also modulates mTOR feedback. Constitutive and conditional eIF4B knockout mice; histopathology; flow cytometry for apoptosis; Western blotting for mTOR pathway components; influenza A virus infection model Frontiers in immunology High 34566982
1998 The RNA recognition motif (RRM) of yeast Tif3/eIF4B contains one RNA-binding domain; at least one additional RNA-binding domain is present in the C-terminal two-thirds (the seven-repeat region). The RRM domain and at least three of the seven repeat motifs are each required for RNA strand-exchange activity, in vitro translation stimulation, and in vivo complementation of tif3Δ cells. N- and C-terminal deletion analysis; in vivo complementation assays; in vitro translation assays; ssRNA binding assays; RNA strand-exchange assays RNA (New York, N.Y.) High 9769100
2000 eIF4B increases ATP binding affinity of wheat germ eIF4A ~10-fold (without significantly altering ADP affinity), enabling eIF4A to cycle through conformational changes required for processive RNA unwinding. Direct fluorescence ATP/ADP binding measurements, ATPase assays, RNA helicase assays with purified wheat germ factors Biochemistry High 10801326
2000 Wheat germ PABP interaction with eIF-iso4G increases the ATPase and RNA helicase activity of the (eIF4A + eIF4B + eIF-iso4F) complex; PABP enhances mRNA scanning rate of the initiation factor complex. ATPase kinetic assays (kcat/Km measurements), RNA helicase (duplex unwinding) assays with purified wheat germ factors in various combinations The Journal of biological chemistry Medium 10748132
2011 KSHV ORF45/RSK-mediated phosphorylation of eIF4B increases its assembly into translation initiation complexes and facilitates protein translation during KSHV lytic replication; this phosphorylation is resistant to rapamycin and U0126, distinguishing it from canonical S6K and ERK/RSK pathways. Co-immunoprecipitation of eIF4B in initiation complexes, phospho-specific assays, siRNA knockdown of ORF45/RSK1/2, phosphorylation-deficient eIF4B mutants, viral gene expression and progeny virus production assays The Journal of biological chemistry Medium 21994950
2025 eIF4F (via eIF4A and eIF4B loading eRF1 into the A site, and eIF4G1 stimulating eRF3 GTPase activity) promotes translation termination in a reconstituted mammalian system; closed-loop mRNA structure (PABP–eRF3 interaction plus eIF4F) facilitates termination. The MIF4G domain is the minimal eIF4G domain required for termination stimulation. Reconstituted mammalian translation termination system with purified components; domain mapping of eIF4G; measurement of eRF3 GTPase activity; peptide release assays Nucleic acids research High 40066881
2019 eIF4B mediates RAN-translation of the toxic GR dipeptide from expanded G4C2 repeats in a C9orf72 ALS/FTD Drosophila model; loss-of-function of eIF4B (and eIF4H) reduces GR-GFP production and G4C2-associated toxicity. Unbiased loss-of-function genetic screen in Drosophila G4C2 model; GFP reporter for GR production; eye toxicity assays; validation in patient-derived cells and post-mortem ALS/FTD tissue Acta neuropathologica communications Medium 31023341
2024 eIF4B IDR (intrinsically disordered region) orchestrates concentration-dependent self-association: large dynamic oligomers form before mesoscopic phase separation; this behavior is sensitive to ionic strength and molecular crowding, suggesting regulation by PTMs and binding partners. Single-molecule spectroscopy, molecular simulations, integration of conformational ensemble analysis; ionic strength and crowding perturbations Nature communications Medium 39384813
2025 Pathogenic FTLD-tau binds eIF4B, causing its dissociation from the translation initiation complex and reducing dendritic eIF4B levels; this blocks activity-dependent local protein synthesis in dendrites and impairs synaptic plasticity. Inhibiting the tau–eIF4B interaction or increasing eIF4B levels restores local translation and plasticity. Co-immunoprecipitation of tau with eIF4B, ribosome profiling/translatomics in FTLD-tau neurons, dendritic localization imaging, rescue experiments with eIF4B overexpression and tau-eIF4B interaction inhibition bioRxivpreprint Medium 41279029
2026 ERK2 directly phosphorylates eIF4B at Ser93; this phosphorylation decreases ubiquitination-mediated eIF4B degradation, enhances eIF4B translation activity, and facilitates translation of mesenchymal markers to promote EMT and colorectal cancer metastasis. Phosphoproteomic (TMT-labeling), phospho-specific antibody validation, in vitro kinase assay (ERK2 + eIF4B), ubiquitination assays, in vitro and in vivo CRC models Cell death & disease Medium 41490890
2019 FLT3-ITD activates RSK1 (via MEK/ERK and PDK1), which phosphorylates eIF4B at S422 and, cooperatively with PIM kinases, at S406, activating eIF4B and mTORC1/S6K/4EBP1 to enhance cap-dependent translation and AML cell survival. Pharmacological inhibition (RSK, MEK, PIM, PI3K inhibitors), phospho-specific Western blotting, genetic knockdown, AML cell line proliferation and survival assays Cancers Medium 31756944

Source papers

Stage 0 corpus · 86 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. The EMBO journal 415 16763566
2001 Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F. The Journal of biological chemistry 263 11418588
1997 Translation initiation factors eIF-iso4G and eIF-4B interact with the poly(A)-binding protein and increase its RNA binding activity. The Journal of biological chemistry 225 9195926
2014 The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation. Current biology : CB 218 25220053
1990 Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters. The Journal of biological chemistry 164 2191953
1996 A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3. Molecular and cellular biology 158 8816444
1991 Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E. The Journal of biological chemistry 150 1989989
2012 Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. The Journal of biological chemistry 113 23105104
2010 eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways. Cell cycle (Georgetown, Tex.) 108 20948310
2001 IRES interaction with translation initiation factors: functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII. RNA (New York, N.Y.) 103 11565745
1994 The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence. Molecular and cellular biology 97 8139536
1991 RNA unwinding in translation: assembly of helicase complex intermediates comprising eukaryotic initiation factors eIF-4F and eIF-4B. Molecular and cellular biology 94 1719376
1995 The Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF-4B, have RNA annealing activity. The EMBO journal 87 7543843
2014 eIF4B, eIF4G and RNA regulate eIF4A activity in translation initiation by modulating the eIF4A conformational cycle. Nucleic acids research 82 24848014
2008 Interactions between eIF4AI and its accessory factors eIF4B and eIF4H. RNA (New York, N.Y.) 81 18719248
2016 eIF4B stimulates translation of long mRNAs with structured 5' UTRs and low closed-loop potential but weak dependence on eIF4G. Proceedings of the National Academy of Sciences of the United States of America 80 27601676
2018 Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL. Nature communications 77 29483509
2000 The phosphorylation state of poly(A)-binding protein specifies its binding to poly(A) RNA and its interaction with eukaryotic initiation factor (eIF) 4F, eIFiso4F, and eIF4B. The Journal of biological chemistry 77 10747998
1987 Identification of two messenger RNA cap binding proteins in wheat germ. Evidence that the 28-kDa subunit of eIF-4B and the 26-kDa subunit of eIF-4F are antigenically distinct polypeptides. The Journal of biological chemistry 76 2440886
2011 Phosphorylation of eukaryotic translation initiation factor 4B (EIF4B) by open reading frame 45/p90 ribosomal S6 kinase (ORF45/RSK) signaling axis facilitates protein translation during Kaposi sarcoma-associated herpesvirus (KSHV) lytic replication. The Journal of biological chemistry 67 21994950
1994 Two structural domains of initiation factor eIF-4B are involved in binding to RNA. The Journal of biological chemistry 64 8182051
1995 Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site. Journal of virology 63 7707504
2013 eIF4B and eIF4G jointly stimulate eIF4A ATPase and unwinding activities by modulation of the eIF4A conformational cycle. Journal of molecular biology 62 24080224
2010 Synergistic activation of eIF4A by eIF4B and eIF4G. Nucleic acids research 62 21113024
2016 Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Proceedings of the National Academy of Sciences of the United States of America 60 27528663
2000 Wheat germ poly(A)-binding protein increases the ATPase and the RNA helicase activity of translation initiation factors eIF4A, eIF4B, and eIF-iso4F. The Journal of biological chemistry 60 10748132
2000 Wheat germ translation initiation factor eIF4B affects eIF4A and eIFiso4F helicase activity by increasing the ATP binding affinity of eIF4A. Biochemistry 59 10801326
2012 Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains. RNA (New York, N.Y.) 57 23236192
2004 Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H. Journal of virology 57 15078951
2013 eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes. Cancer research 55 23749639
2014 Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control. The Journal of cell biology 52 25332164
2009 Evidence for variation in the optimal translation initiation complex: plant eIF4B, eIF4F, and eIF(iso)4F differentially promote translation of mRNAs. Plant physiology 51 19493973
2019 FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM. Cancers 41 31756944
2019 Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B. Cancer letters 39 31875526
2019 eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Acta neuropathologica communications 38 31023341
2002 Interaction of translation initiation factor eIF4B with the poliovirus internal ribosome entry site. Journal of virology 38 11836388
2016 eIF4B stimulates eIF4A ATPase and unwinding activities by direct interaction through its 7-repeats region. RNA biology 37 27858515
2017 Eukaryotic translation initiation factor 4G (eIF4G) coordinates interactions with eIF4A, eIF4B, and eIF4E in binding and translation of the barley yellow dwarf virus 3' cap-independent translation element (BTE). The Journal of biological chemistry 36 28242763
2007 eIF4G, eIFiso4G, and eIF4B bind the poly(A)-binding protein through overlapping sites within the RNA recognition motif domains. The Journal of biological chemistry 36 17606619
1998 The phosphorylation state of the wheat translation initiation factors eIF4B, eIF4A, and eIF2 is differentially regulated during seed development and germination. The Journal of biological chemistry 32 9685349
2007 Expression and purification of recombinant wheat translation initiation factors eIF1, eIF1A, eIF4A, eIF4B, eIF4F, eIF(iso)4F, and eIF5. Methods in enzymology 30 17913646
1999 Translation initiation factor eIF4B interacts with a picornavirus internal ribosome entry site in both 48S and 80S initiation complexes independently of initiator AUG location. Journal of virology 30 10438840
1999 Interaction of eukaryotic initiation factor eIF4B with the internal ribosome entry site of foot-and-mouth disease virus is independent of the polypyrimidine tract-binding protein. Journal of virology 26 10364367
2012 Yeast eukaryotic initiation factor 4B (eIF4B) enhances complex assembly between eIF4A and eIF4G in vivo. The Journal of biological chemistry 24 23184954
2016 Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2α Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins. The Journal of biological chemistry 22 27836976
2013 The over-expression of Pim-2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B. The Prostate 22 23813671
2010 Competitive and noncompetitive binding of eIF4B, eIF4A, and the poly(A) binding protein to wheat translation initiation factor eIFiso4G. Biochemistry 22 20795652
1998 The RNA recognition motif of yeast translation initiation factor Tif3/eIF4B is required but not sufficient for RNA strand-exchange and translational activity. RNA (New York, N.Y.) 22 9769100
2016 eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants. Oncotarget 21 26848623
1978 Initiation factor eIF-4B (IF-M3)-dependent recognition and translation of capped versus uncapped eukaryotic mRNAs. The Journal of biological chemistry 21 681329
2014 Abrogating phosphorylation of eIF4B is required for EGFR and mTOR inhibitor synergy in triple-negative breast cancer. Breast cancer research and treatment 19 25129346
2017 eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology. Scientific reports 18 28874824
2009 Kinetic mechanism for the binding of eIF4F and tobacco Etch virus internal ribosome entry site rna: effects of eIF4B and poly(A)-binding protein. The Journal of biological chemistry 18 19858189
2021 Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease. Cell death & disease 17 34349120
2010 Effects of neonatal MK-801 treatment on p70S6K-S6/eIF4B signal pathways and protein translation in the frontal cortex of the developing rat brain. The international journal of neuropsychopharmacology 16 20064280
2021 Deficiency of eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity. Frontiers in immunology 15 34566982
2013 RSK activation of translation factor eIF4B drives abnormal increases of laminin γ2 and MYC protein during neoplastic progression to squamous cell carcinoma. PloS one 13 24205356
2010 Poly(A) tail affects equilibrium and thermodynamic behavior of tobacco etch virus mRNA with translation initiation factors eIF4F, eIF4B and PABP. Biochimica et biophysica acta 13 20723624
1991 Evidence that eukaryotic initiation factor (eIF) 2 is a cap-binding protein that stimulates cap recognition by eIF-4B and eIF-4F. The Journal of biological chemistry 13 2016328
2015 C/EBPβ-LAP*/LAP Expression Is Mediated by RSK/eIF4B-Dependent Signalling and Boosted by Increased Protein Stability in Models of Monocytic Differentiation. PloS one 12 26646662
2023 A novel circular RNA circRBMS3 regulates proliferation and metastasis of osteosarcoma by targeting miR-424-eIF4B/YRDC axis. Aging 10 36897170
1993 Further biochemical characterization of rabbit reticulocyte eIF-4B. Archives of biochemistry and biophysics 10 8460942
2025 YTHDF3 drives tumor growth and metastasis by recruiting eIF4B to promote Notch2 translation in breast cancer. Cancer letters 9 39924078
1988 Identification of the 80-kDa protein that crosslinks to the cap structure of eukaryotic mRNAs as initiation factor eIF-4B. Archives of biochemistry and biophysics 9 3395129
2024 Disordered regions of human eIF4B orchestrate a dynamic self-association landscape. Nature communications 8 39384813
2022 PARK2 regulates eIF4B-driven lymphomagenesis. Molecular cancer research : MCR 8 35105670
2021 eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma. Biochemical and biophysical research communications 7 34403810
2012 In vitro activity of human translation initiation factor eIF4B is not affected by phosphomimetic amino acid substitutions S422D and S422E. Biochimie 7 22750809
2024 Poly(A)-binding protein promotes VPg-dependent translation of potyvirus through enhanced binding of phosphorylated eIFiso4F and eIFiso4F∙eIF4B. PloS one 6 38696388
2025 Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 5 39950948
2025 Eukaryotic initiation factors eIF4F and eIF4B promote translation termination upon closed-loop formation. Nucleic acids research 5 40066881
2022 PP2A promotes apoptosis and facilitates docetaxel sensitivity via the PP2A/p-eIF4B/XIAP signaling pathway in prostate cancer. Oncology letters 5 35154432
2013 Impaired binding of standard initiation factors eIF3b, eIF4G and eIF4B to domain V of the live-attenuated coxsackievirus B3 Sabin3-like IRES--alternatives for 5'UTR-related cardiovirulence mechanisms. Diagnostic pathology 5 24063684
2016 Muscarinic acetylcholine receptors mediate eIF4B phosphorylation in SNU-407 colon cancer cells. Biochemical and biophysical research communications 4 27773818
2023 Backbone resonance assignments of the C-terminal region of human translation initiation factor eIF4B. Biomolecular NMR assignments 3 37368134
2022 eIF4B mRNA Translation Contributes to Cleavage Dynamics in Early Sea Urchin Embryos. Biology 2 36290313
2020 [Synergistic role of JAK/STAT5 and PI3K/AKT signaling pathways in regulating eIF4B in acute leukemia]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2 33244935
2025 CCP1 Inhibits Pulmonary Fibrosis by Suppressing Fibrotic Progression Through the EIF4B/PI3K/AKT Pathways. Cell biology international 1 40590568
2025 Pathogenic tau inhibits synaptic plasticity by blocking eIF4B-mediated local protein synthesis. bioRxiv : the preprint server for biology 1 41279029
2024 Elaiophylin targets EIF4B to suppress the growth of esophageal squamous cell carcinoma via the PI3K/AKT signaling pathway. Cancer letters 1 39694222
2026 EIF4B Ser93 phosphorylation by ERK2 promotes epithelial-mesenchymal transition to drive colorectal cancer metastasis. Cell death & disease 0 41490890
2026 Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules and activates ChaC2 translation to promote polyunsaturated lipids-supported peritoneal metastasis in gastric cancer. Cancer letters 0 41780839
2025 Trypanosomatid DRBD9s are likely to be eIF4B orthologues. Journal of biosciences 0 39703104
2024 Methionyl-Methionine Dipeptide Enhances Mammogenesis and Lactogenesis by Suppressing the Expression of a Novel Long Noncoding RNA MGPNCR to Inhibit eIF4B Dephosphorylation. Journal of agricultural and food chemistry 0 38501560
2024 LncRNA HILPDA promotes contrast-induced acute kidney injury by recruiting eIF4B to upregulate XPO1 expression. Toxicology research 0 38957783
2022 [Effect of eIF4B knockout on apoptosis of mouse fetal liver cells]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 0 36151816

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