Affinage

FAU

Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein · UniProt P62861

Length
133 aa
Mass
14.4 kDa
Annotated
2026-06-09
64 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FAU encodes a precursor fusion protein in which a ubiquitin-like domain (FUBI/MNSFβ) is joined in-frame to ribosomal protein eS30 (S30), expressed ubiquitously from a housekeeping gene (PMID:1326960, PMID:8395683). Proteolytic separation of the two domains is an obligatory maturation step: the deubiquitinase USP36 cleaves FUBI-eS30, and this processing is required for cytoplasmic 40S ribosomal subunit maturation, 18S rRNA processing, and recycling of late-acting biogenesis factors, while non-cleavable mutants block these steps (PMID:34318747). USP36 substrate selectivity for FUBI is explained at the structural level, and USP16 acts as a second, synergistic FUBI-deconjugating enzyme (PMID:37443395). The liberated FUBI domain functions as a ubiquitin-like modifier that covalently conjugates to target proteins via its C-terminal Gly74, including the pro-apoptotic protein Bcl-G, 10-formyltetrahydrofolate dehydrogenase (FDH) at Lys72, HSP60 at Lys481, and IGF2BP2 (PMID:23298187, PMID:26192119, PMID:30710197, PMID:34668606). Through these conjugations FAU acts as a pro-apoptotic, caspase-dependent regulator whose ectopic expression induces apoptosis blocked by Bcl-2 and caspase inhibitors, and whose loss confers resistance to dexamethasone-, UV-, and cisplatin-induced cell death; Bcl-G is an essential downstream effector of this apoptotic activity (PMID:15543234, PMID:21550398, PMID:23298187). In macrophages FUBI tunes innate-immune signaling: the FUBI·Bcl-G complex inhibits MEK1-driven ERK1/2 activation and AP-1/Cox-2 output, FUBI-endophilin II suppresses Dectin-1 phagocytic signaling upstream of IKK, and FUBI controls LPS-induced TNFα by binding RC3H1 and driving its sequestration into stress granules to relieve TNFα mRNA decay (PMID:16621790, PMID:20849826, PMID:23298187, PMID:39260307). Beyond signaling, FUBI noncovalently associates with HSPA8 in an ATP-dependent manner during osteoclastogenesis and, through covalent conjugation that stabilizes IGF2BP2, promotes trophoblast invasion, with trophoblast-specific knockout causing embryonic growth retardation and fetal loss (PMID:27581120, PMID:34668606).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1992 High

    Established the unusual architecture of the gene — a ubiquitin-like domain (FUBI) fused to a ribosomal protein (eS30) — defining the central question of how one transcript serves two functions.

    Evidence cDNA cloning and genomic structure/sequence analysis of the 133-aa precursor

    PMID:1326960 PMID:8395683

    Open questions at the time
    • Did not establish whether or how the fusion is processed
    • No functional role assigned to either domain
  2. 1993 Medium

    Inferred that FUBI retains the conserved residues needed for ubiquitin-like conjugation chemistry, raising the possibility it acts as a covalent modifier rather than a vestigial domain.

    Evidence Comparative sequence analysis of conserved catalytic/conjugation residues

    PMID:8395683

    Open questions at the time
    • Sequence inference only — no demonstration of actual conjugation
    • No substrate identified
  3. 2003 Medium

    Showed the two FAU domains carry separable functions, with FUBI driving anchorage-independent transformation and S30 conferring arsenite resistance, supporting the idea that the cleavage products act independently.

    Evidence Domain-separated expression constructs with soft-agar and arsenite-resistance assays in HOS cells

    PMID:12660817

    Open questions at the time
    • Did not identify the protease responsible for separation
    • Mechanism of transformation by FUBI not defined
  4. 2004 Medium

    Defined FAU as a pro-apoptotic, caspase-upstream factor and linked its loss to chemoresistance, establishing a candidate tumor-suppressor role.

    Evidence Sense/antisense expression, colony-forming assays, Bcl-2 and caspase inhibitor blockade of apoptosis

    PMID:15543234

    Open questions at the time
    • Molecular effector of apoptosis unknown
    • Which domain mediates the apoptotic effect not resolved
  5. 2005 Low

    Probed a possible nuclear role for free FUBI through specific binding to histone 2A and detection of nuclear FUBI adducts after mitogen activation.

    Evidence GST-pulldown, nuclear fractionation, immunodetection in T cells

    PMID:15649767

    Open questions at the time
    • Single pulldown/fractionation without functional consequence
    • Significance of histone 2A binding never followed up
  6. 2006 Medium

    Identified Bcl-G as a covalent FUBI conjugate and placed the FUBI·Bcl-G complex as an inhibitor of MEK1-driven ERK signaling, connecting FUBI to macrophage inflammatory output.

    Evidence Reciprocal Co-IP, siRNA knockdown, ERK activation and TNFα assays in macrophages

    PMID:16621790

    Open questions at the time
    • Conjugation site not yet mapped
    • Single lab
  7. 2011 Medium

    Demonstrated by genetic epistasis that Bcl-G is an essential downstream effector of FAU-induced apoptosis, fixing the order of the apoptotic pathway.

    Evidence Double siRNA knockdown of FAU and Bcl-G with flow-cytometry apoptosis readout in T-cell lines

    PMID:21550398

    Open questions at the time
    • Does not explain how the FUBI-Bcl-G complex engages the caspase machinery
    • Single lab
  8. 2010 Medium

    Expanded the FUBI conjugation repertoire to endophilin II and placed the complex upstream of IKK in Dectin-1 phagocytic signaling, broadening FUBI's role in innate immunity.

    Evidence Co-IP, siRNA knockdown, phagocytosis and IκBα degradation assays in macrophages

    PMID:20849826

    Open questions at the time
    • Conjugation site not mapped
    • Single lab
  9. 2013 High

    Pinpointed C-terminal Gly74 as the conjugation residue (G74A abolishes activity), establishing FUBI as a bona fide covalent ubiquitin-like modifier driving macrophage apoptosis and ERK/AP-1/Cox-2 suppression.

    Evidence Site-directed G74A mutagenesis, co-transfection, EMSA for AP-1, Cox-2 activity assays

    PMID:23298187

    Open questions at the time
    • Conjugating enzyme machinery (E1/E2/E3-like) for FUBI not identified
    • Single lab
  10. 2015 Medium

    Mapped a defined FUBI conjugation site (Gly74-Lys72) on FDH and linked the conjugate to dexamethasone-induced thymocyte apoptosis, providing biochemical proof of substrate specificity.

    Evidence Chromatographic purification, MALDI-TOF MS site mapping, siRNA double knockdown, apoptosis assay

    PMID:26192119

    Open questions at the time
    • Functional consequence of FDH conjugation at the enzymatic level unclear
    • Single lab
  11. 2016 Medium

    Showed FUBI noncovalently binds the chaperone HSPA8 in an ATP-dependent manner and participates in RANKL-driven osteoclastogenesis, extending FUBI interactions beyond covalent conjugation.

    Evidence MS fingerprinting, in vitro ATP-dependent binding, siRNA double knockdown, osteoclastogenesis and phospho-ERK/p38 assays

    PMID:27581120

    Open questions at the time
    • Structural basis of ATP-dependent binding unknown
    • Single lab
  12. 2017 Medium

    Revealed a distinct quality-control role in which FAU preferentially binds mutant F508del-CFTR and targets it for degradation, such that FAU silencing rescues mutant CFTR trafficking.

    Evidence High-throughput siRNA screen, CFTR anion-transport and trafficking assays, Co-IP in bronchial epithelial cells

    PMID:29158263

    Open questions at the time
    • Whether FUBI conjugation mediates the CFTR interaction not established
    • Single lab
  13. 2019 Medium

    Added HSP60 (Gly74-Lys481) as a FUBI conjugate that negatively regulates FUBI's pro-apoptotic activity, defining a built-in regulatory brake on FUBI signaling.

    Evidence GST-pulldown, MALDI-TOF MS site mapping, siRNA epistasis, apoptosis/TNFα assays in macrophages

    PMID:30710197

    Open questions at the time
    • Mechanism by which HSP60 conjugation suppresses FUBI activity unknown
    • Single lab
  14. 2021 High

    Resolved the central processing question: USP36 cleaves FUBI-eS30, and this step is required for cytoplasmic 40S maturation, linking FAU directly to ribosome biogenesis.

    Evidence Non-cleavable mutants, RNAi/CRISPRi USP36 depletion, in vitro cleavage with purified USP36, rRNA maturation analysis

    PMID:34318747

    Open questions at the time
    • Regulation of USP36-mediated processing not defined
    • Fate of liberated FUBI relative to its conjugation activity not connected
  15. 2021 Medium

    Connected FUBI to TNFα regulation via interaction with the decay factor RC3H1, and to placental development via covalent stabilization of IGF2BP2, demonstrating in vivo physiological roles.

    Evidence Co-IP and siRNA epistasis in THP1 macrophages; trophoblast-specific Cre knockout mouse, Co-IP, invasion assays

    PMID:34589082 PMID:34668606

    Open questions at the time
    • RC3H1 binding mode not yet mapped at this stage
    • IGF2BP2 conjugation site not defined
  16. 2023 High

    Provided the structural basis for USP36's selectivity toward FUBI and identified USP16 as a synergistic second FUBI-deconjugating enzyme, explaining why most DUBs cannot process FUBI.

    Evidence Crystal structures of USP36-FUBI and USP36-ubiquitin, chemoproteomics with FUBI activity-based probes, hydrolase assays

    PMID:37443395

    Open questions at the time
    • Relative in vivo contributions of USP36 vs USP16 not quantified
    • No conjugating enzymes identified
  17. 2024 Medium

    Refined the FUBI–RC3H1 mechanism, showing FUBI (101-133) binds RC3H1 (81-326) and drives RC3H1 into stress granules together with FMR1 to relieve TNFα mRNA decay.

    Evidence Peptide-mapping Co-IP, stress granule imaging, TNFα mRNA stability assays, inhibitory peptide rescue

    PMID:39260307

    Open questions at the time
    • Whether this requires covalent FUBI conjugation unresolved
    • Single lab
  18. 2025 Medium

    Used synthetic FUBI/di-FUBI tools to uncover IMPDH1 and UCHL3 as di-FUBI interactors and showed di-FUBI inhibits UCHL3, hinting at FUBI-chain-based regulation analogous to ubiquitin chains.

    Evidence Synthetic FUBI activity-based probes, chemoproteomics, in vitro UCHL3 cleavage inhibition assay

    PMID:40464359

    Open questions at the time
    • Existence and biological role of FUBI chains in cells not demonstrated
    • Novel findings not yet replicated

Open questions

Synthesis pass · forward-looking unresolved questions
  • The enzymatic machinery that conjugates FUBI to its substrates (FUBI E1/E2/E3 equivalents) and the cellular regulation balancing FUBI-eS30 processing against free-FUBI conjugation remain unknown.
  • No FUBI-activating/conjugating enzymes identified
  • How processing and conjugation pools are coordinated is unresolved
  • Tumor-suppressor role not validated in vivo

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0031386 protein tag activity 5 GO:0098772 molecular function regulator activity 4 GO:0005198 structural molecule activity 2
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 2 GO:0005840 ribosome 2
Pathway
R-HSA-168256 Immune System 4 R-HSA-5357801 Programmed Cell Death 3 R-HSA-8953854 Metabolism of RNA 2 R-HSA-1852241 Organelle biogenesis and maintenance 1
Partners
ALDH1L1BCL2L14HSPA8HSPD1IGF2BP2RC3H1USP16USP36

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 FAU encodes a fusion protein consisting of a ubiquitin-like protein (FUBI) fused in-frame to ribosomal protein S30 (eS30), forming a single 133 amino acid precursor protein expressed ubiquitously from a housekeeping-type gene with no TATA box. cDNA cloning, genomic structure analysis, sequence analysis Biochemical and biophysical research communications High 1326960 8395683
1993 The FUBI ubiquitin-like domain of FAU conserves amino acid residues known to be involved in the ATP-dependent proteolytic activity of ubiquitin, suggesting it can participate in ubiquitin-like conjugation chemistry. Sequence analysis and comparative biochemistry of conserved residues Oncogene Medium 8395683
2004 FAU (fau sense orientation overexpression) induces apoptosis that is inhibited by Bcl-2 and by caspase inhibitors, placing FAU upstream of the caspase cascade; antisense fau suppresses endogenous fau mRNA and confers resistance to dexamethasone-, UV-, and cisplatin-induced apoptosis. Functional expression cloning, antisense suppression, colony-forming assay, overexpression with pharmacological inhibitors Oncogene Medium 15543234
2006 The FAU ubiquitin-like domain (MNSFβ/FUBI) covalently binds to the pro-apoptotic protein Bcl-G; the MNSFβ·Bcl-G complex associates with ERK1/2 and directly inhibits ERK activation by MEK1; siRNA knockdown of MNSFβ enhances LPS-induced ERK1/2 activation and TNFα production in macrophages. Co-immunoprecipitation, siRNA knockdown, ERK activation assay, TNFα ELISA, transfection of MNSFβ expression construct The Journal of biological chemistry Medium 16621790
2011 FAU promotes apoptosis in human T-cell lines through a pathway requiring Bcl-G; prior knockdown of Bcl-G ablates FAU-induced basal apoptosis, establishing Bcl-G as an essential downstream effector of FAU-mediated apoptosis. Ectopic FAU expression, siRNA knockdown of FAU and Bcl-G, apoptosis assays (flow cytometry), UV-induced apoptosis assays Biochimica et biophysica acta Medium 21550398
2010 MNSFβ/FUBI covalently conjugates to endophilin II; the MNSFβ/endophilin II complex inhibits Dectin-1-mediated phagocytosis and suppresses the signal pathway upstream of IKK activation (but not downstream of TLR2 signaling) in macrophages. Co-immunoprecipitation, siRNA knockdown of endophilin II and MNSFβ, phagocytosis assay, TNFα measurement, IκBα degradation assay Biochemical and biophysical research communications Medium 20849826
2013 MNSFβ/FUBI covalently binds to Bcl-G via a linkage requiring the C-terminal Gly74 of MNSFβ (G74A mutant abolishes enhancement of apoptosis); the MNSFβ-Bcl-G complex promotes LPS/IFNγ-induced apoptosis in macrophages and down-regulates the ERK/AP-1 signaling cascade, leading to decreased Cox-2 activity. Site-directed mutagenesis (G74A), co-transfection, siRNA knockdown, apoptosis assays, EMSA for AP-1 activity, Cox-2 activity measurement The FEBS journal High 23298187
2015 MNSFβ/FUBI purified covalently conjugates to cytosolic 10-formyltetrahydrofolate dehydrogenase (FDH) via a linkage between C-terminal Gly74 of MNSFβ and Lys72 of FDH; this complex is induced by dexamethasone in thymocytes and its double knockdown strongly reduces dexamethasone-induced apoptosis. Sequential chromatography purification, MALDI-TOF MS fingerprinting, siRNA double knockdown, apoptosis assay Biochemical and biophysical research communications Medium 26192119
2016 MNSFβ/FUBI noncovalently binds to HSPA8 (HSC70/heat shock 70-kDa protein 8) in the presence of ATP in vitro; double knockdown of MNSFβ and HSPA8 inhibits RANKL-induced osteoclastogenesis and suppresses RANKL-induced ERK1/2, p38 phosphorylation, and TNFα production. MALDI-TOF MS fingerprinting, in vitro binding assay with ATP, siRNA double knockdown, osteoclastogenesis assay, phospho-ERK/p38 immunoblot Molecular and cellular biochemistry Medium 27581120
2017 FAU silencing by siRNA rescues F508del-CFTR function in bronchial epithelial cells by increasing plasma membrane targeting and anion transport of mutant CFTR; FAU shows preferential physical interaction with mutant (F508del) CFTR but not wild-type CFTR, and this interaction leads to mutant CFTR degradation. High-throughput siRNA screen, CFTR functional assay (anion transport), Co-immunoprecipitation, plasma membrane trafficking assay The Journal of biological chemistry Medium 29158263
2019 MNSFβ/FUBI covalently conjugates to HSP60 via a linkage between C-terminal Gly74 of MNSFβ and Lys481 of HSP60; HSP60 siRNA reverses the inhibition of apoptosis caused by MNSFβ siRNA in LPS/IFNγ-stimulated macrophages, indicating HSP60 negatively regulates MNSFβ biological activity. GST-pulldown purification, MALDI-TOF MS fingerprinting of conjugation site, siRNA knockdown, apoptosis and TNFα assay Molecular and cellular biochemistry Medium 30710197
2021 Processing of the FUBI-eS30 fusion protein (encoded by FAU) is required for cytoplasmic 40S ribosomal subunit maturation; non-cleavable FUBI-eS30 mutants impair 18S rRNA maturation and prevent recycling of late-acting ribosome biogenesis factors. The deubiquitinase USP36 is identified as the FUBI-eS30 processing protease: USP36 depletion by RNAi or CRISPRi impairs FUBI-eS30 cleavage, and purified USP36 cleaves FUBI-eS30 in vitro. Non-cleavable mutant expression, differential affinity purification, RNAi/CRISPRi depletion of USP36, in vitro cleavage assay with purified USP36, rRNA maturation analysis eLife High 34318747
2021 MNSFβ/FUBI interacts with RC3H1 (a suppressor of TNFα transcription) in macrophages; this interaction promotes TNFα production, and specific knockdown of MNSFβ decreases TNFα production in a manner reversible by RC3H1 inhibition. Co-immunoprecipitation in THP1-derived macrophages, siRNA knockdown of MNSFβ and RC3H1, TNFα measurement Frontiers in immunology Medium 34589082
2021 MNSFβ/FUBI covalently conjugates to IGF2BP2 in trophoblasts, stabilizing IGF2BP2 protein and thereby promoting trophoblast invasiveness; trophoblast-specific knockout of MNSFβ in mice causes limited trophoblast invasion, embryonic growth retardation, and fetal loss. Trophoblast-specific Cre knockout mouse, Co-immunoprecipitation, immunoblotting, Transwell invasion assay, IHC/IF Cell proliferation Medium 34668606
2023 Crystal structures of USP36 complexed with FUBI and with ubiquitin reveal the substrate recognition mechanism of USP36 for FUBI; structural basis explains why most other deubiquitinases cannot cleave FUBI. USP16 is identified as a second dual ubiquitin/FUBI deubiquitinase with a synergistic role in FUBI-S30 maturation, discovered by chemoproteomics using FUBI-based activity-based probes. Crystal structure determination of USP36-FUBI and USP36-ubiquitin complexes, chemoproteomics with FUBI activity-based probes, FUBI C-terminal hydrolase activity assay, USP16 functional characterization Nature chemical biology High 37443395
2024 MNSFβ/FUBI (residues 101-133) interacts with RC3H1 (residues 81-326); MNSFβ promotes LPS-induced TNFα expression by facilitating stress granule (SG) formation and translocation of RC3H1 to SGs (via interaction with RC3H1 and FMR1), thereby inactivating RC3H1's promotion of TNFα mRNA degradation. Peptide-mapping Co-immunoprecipitation, stress granule imaging, siRNA knockdown, TNFα mRNA stability assay, designed inhibitory peptide (HEPN2) rescue experiments International immunopharmacology Medium 39260307
2025 Using synthetic FUBI chemical tools (activity-based probes, di-FUBI), IMPDH1 and UCHL3 are identified as novel di-FUBI-specific interactors; di-FUBI inhibits UCHL3 deubiquitinase cleavage activity in a concentration-dependent manner, revealing a regulatory interplay between UCHL3 and FUBI chains. Synthetic FUBI platform with activity-based probes, chemoproteomics in cell lysates, in vitro UCHL3 cleavage inhibition assay Chembiochem Medium 40464359
2005 The FUBI ubiquitin-like domain (Ubi-L) of FAU noncovalently and specifically binds to histone 2A; free Ubi-L is detected in nuclei of T cells and nuclear Ubi-L adducts increase upon mitogen activation, suggesting a nuclear role for FUBI. GST-pulldown binding assay, nuclear fractionation, immunodetection of Ubi-L in nuclear/chromatin fractions Comparative biochemistry and physiology. Part B Low 15649767
2003 When FAU's two domains are expressed separately, only the FUBI domain transforms human osteogenic sarcoma (HOS) cells to anchorage-independence, while only the S30 domain confers arsenite resistance, functionally dissociating the two domains of the FAU fusion protein. Domain-separated expression constructs, soft agar anchorage-independence assay, arsenite resistance assay Oncogene Medium 12660817
2014 In C. elegans, knockdown of Ce-rps30 (FAU ortholog) confers extended lifespan, increased lipid storage, and shortened body length comparable to dauer larvae; the S30 domain localizes to the nucleus while the UBiL (FUBI) domain accumulates in the cytoplasm, and synergism between the two domains regulates lifespan and reproduction. RNAi knockdown in C. elegans, transgenic overexpression, subcellular localization by fluorescent reporter, lifespan and phenotype assays International journal for parasitology Medium 25058511

Source papers

Stage 0 corpus · 64 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1991 The fub-1 mutation blocks initial myofibril formation in zebrafish muscle pioneer cells. Developmental biology 112 1936560
1992 Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein. Biochemical and biophysical research communications 62 1326960
1999 Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis. Carcinogenesis 47 10069470
1993 fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus. Oncogene 45 8395683
2019 Establishment of a brain cell line (FuB-1) from mummichog (Fundulus heteroclitus) and its application to fish virology, immunity and nanoplastics toxicology. The Science of the total environment 41 31791770
2011 Candidate tumour suppressor Fau regulates apoptosis in human cells: an essential role for Bcl-G. Biochimica et biophysica acta 35 21550398
2017 High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel. The Journal of biological chemistry 28 29158263
2004 Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression. Oncogene 27 15543234
2006 The ubiquitin-like protein MNSFbeta regulates ERK-MAPK cascade. The Journal of biological chemistry 26 16621790
2000 Identification of monoclonal nonspecific suppressor factor beta (mNSFbeta) as one of the genes differentially expressed at implantation sites compared to interimplantation sites in the mouse uterus. Molecular reproduction and development 26 10694741
1993 Exclusion of FAU as the multiple endocrine neoplasia type 1 (MEN1) gene. Human molecular genetics 26 8099302
2021 Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36. eLife 25 34318747
2002 Radiolabeled 2'-fluorodeoxyuracil-beta-D-arabinofuranoside (FAU) and 2'-fluoro-5-methyldeoxyuracil-beta -D-arabinofuranoside (FMAU) as tumor-imaging agents in mice. Cancer chemotherapy and pharmacology 25 11976837
2023 Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36. Nature chemical biology 21 37443395
2013 Ubiquitin-like protein MNSFβ covalently binds to Bcl-G and enhances lipopolysaccharide/interferon γ-induced apoptosis in macrophages. The FEBS journal 20 23298187
2010 Ubiquitin-like protein MNSFβ/endophilin II complex regulates Dectin-1-mediated phagocytosis and inflammatory responses in macrophages. Biochemical and biophysical research communications 20 20849826
2016 Ubiquitin-like protein MNSFβ noncovalently binds to molecular chaperone HSPA8 and regulates osteoclastogenesis. Molecular and cellular biochemistry 19 27581120
2003 Expression cloning and characterization of a novel gene that encodes the RNA-binding protein FAU-1 from Pyrococcus furiosus. The Biochemical journal 19 12614195
1993 Assignment of the human FAU gene to a subregion of chromosome 11q13. Genomics 19 8406491
2003 fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence. Oncogene 18 12660817
2014 Hc-fau, a novel gene regulating diapause in the nematode parasite Haemonchus contortus. International journal for parasitology 17 25058511
2012 Protection of hydroquinone-induced apoptosis by downregulation of Fau is mediated by NQO1. Free radical biology & medicine 15 22687461
2021 Amphioxus ribosomal proteins RPS15, RPS18, RPS19 and RPS30-precursor act as immune effectors via killing or agglutinating bacteria. Fish & shellfish immunology 14 34487827
2011 The improved syntheses of 5-substituted 2'-[18F]fluoro-2'-deoxy-arabinofuranosyluracil derivatives ([18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU) using a multistep one-pot strategy. Nuclear medicine and biology 14 21718941
2005 Imaging the pharmacokinetics of [F-18]FAU in patients with tumors: PET studies. Cancer chemotherapy and pharmacology 14 16001172
2003 Imaging [18F]FAU [1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl) uracil] in dogs. Nuclear medicine and biology 14 12493539
2021 MNSFβ Regulates TNFα Production by Interacting with RC3H1 in Human Macrophages, and Dysfunction of MNSFβ in Decidual Macrophages Is Associated With Recurrent Pregnancy Loss. Frontiers in immunology 13 34589082
2010 Apoptosis regulators Fau and Bcl-G are down-regulated in prostate cancer. The Prostate 13 20687224
2021 MNSFβ regulates placental development by conjugating IGF2BP2 to enhance trophoblast cell invasiveness. Cell proliferation 12 34668606
2015 Functional and Structural Characterization of FAU Gene/Protein from Marine Sponge Suberites domuncula. Marine drugs 12 26198235
2010 FAU regulates carboplatin resistance in ovarian cancer. Genes, chromosomes & cancer 11 19830698
2022 Revealing scenarios of interzeolite conversion from FAU to AEI through the variation of starting materials. Physical chemistry chemical physics : PCCP 9 34647941
2015 Ubiquitin-like protein MNSFβ covalently binds to cytosolic 10-formyltetrahydrofolate dehydrogenase and regulates thymocyte function. Biochemical and biophysical research communications 9 26192119
2007 Immunoneutralization of endometrial monoclonal nonspecific suppressor factor beta (MNSFbeta) inhibits mouse embryo implantation in vivo. Molecular reproduction and development 9 17393421
2023 lncRNA read-through regulates the BX-C insulator Fub-1. eLife 8 37643473
2023 Rational design of proteasome inhibitors based on the structure of the endogenous inhibitor PI31/Fub1. Proceedings of the National Academy of Sciences of the United States of America 8 38091293
2021 Deciphering the effect of FUB1 disruption on fusaric acid production and pathogenicity in Fusarium circinatum. Fungal biology 8 34776231
2019 Heat shock protein 60 negatively regulates the biological functions of ubiquitin-like protein MNSFβ in macrophages. Molecular and cellular biochemistry 8 30710197
2014 Ubiquitin-like protein MNSFβ negatively regulates T cell function and survival. Immunological investigations 8 25180634
1995 The mouse Fau gene: genomic structure, chromosomal localization, and characterization of two retropseudogenes. Genomics 7 7774934
2021 Quercetin and HSC70 coregulate the anti-inflammatory action of the ubiquitin-like protein MNSFβ. Molecular biology reports 6 34773179
2017 An archaeal RNA binding protein, FAU-1, is a novel ribonuclease related to rRNA stability in Pyrococcus and Thermococcus. Scientific reports 6 28978920
2024 MNSFβ promotes LPS-induced TNFα expression by increasing the localization of RC3H1 to stress granules, and the interfering peptide HEPN2 reduces TNFα production by disrupting the MNSFβ-RC3H1 interaction in macrophages. International immunopharmacology 5 39260307
2023 Post-Synthetic Ensembling Design of Hierarchically Ordered FAU-type Zeolite Frameworks for Vacuum Gas Oil Hydrocracking. Angewandte Chemie (International ed. in English) 5 37844013
1996 Isolation, cDNA, and genomic structure of a conserved gene (NOF) at chromosome 11q13 next to FAU and oriented in the opposite transcriptional orientation. Genomics 5 8786148
2020 Downregulated RPS-30 in Angiostrongylus cantonensis L5 plays a defensive role against damage due to oxidative stress. Parasites & vectors 4 33298148
2019 Knockdown of RPL34 suppresses osteosarcoma cell proliferation likely through EIF3/FAU signaling pathway. Translational cancer research 4 35116824
2012 Ubiquitin-like protein MNSFβ regulates TLR-2-mediated signal transduction. Molecular and cellular biochemistry 4 22273981
2005 Noncovalent interaction of MNSFbeta, a ubiquitin-like protein, with histone 2A. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 4 15649767
2005 Crystal structures of the NO and N2O4 sorption complexes of fully dehydrated fully Cd2+-exchanged zeolite X (FAU): coordination of neutral NO and N2O4 to Cd2+. The journal of physical chemistry. B 4 16863145
2025 Design of Ni-FAU Zeolite Bifunctional Materials for Integrated Carbon Dioxide Capture and Methanation: Construction of ultrafine NiO nanoparticles. Journal of colloid and interface science 3 40209428
2016 Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase. Journal of clinical pharmacology 3 27095537
2005 Crystal structure of an ethylene sorption complex of fully vacuum-dehydrated fully Ag+-exchanged zeolite X (FAU). Silver atoms have reduced ethylene to give CH2 2- carbanions at framework oxide vacancies. The journal of physical chemistry. B 3 16853603
2004 Crystal structure of a methylamine sorption complex of fully dehydrated fully Ca2+ -exchanged zeolite X, |Ca46(CH3NH2)16|[Si100Al92O384]-FAU. Langmuir : the ACS journal of surfaces and colloids 3 15461529
2025 Advancing the Exploration of the Ubiquitin-like Protein FUBI with Synthetic Chemical Tools. Chembiochem : a European journal of chemical biology 2 40464359
2024 Homo-trimeric structure of the ribonuclease for rRNA processing, FAU-1, from Pyrococcus furiosus. Journal of biochemistry 2 38302756
2022 Ubiquitin-like protein MNSFβ regulates glycolysis and promotes cell proliferation with HSC70 assistance. Biochemistry and biophysics reports 1 36590871
2020 Porcine ubiquitin-like protein MNSFβ promotes cell apoptosis and covalently binds to BCL-G to enhance staurosporine-induced apoptosis. Annals of translational medicine 1 33209886
2013 [Cloning, eukaryotic expression and spatial expression patterns of porcine MNSFbeta]. Yi chuan = Hereditas 1 24645347
2004 Bme585 I [5'-CCCGC(4/6)-3'], a new isoschizomer of restriction endonuclease Fau I, isolated from a strain of Bacillus mesentericus. Microbiological research 1 15293946
2026 Alkaline hydrothermal valorization of gold tailings into hydrophobic silica aerogels and FAU zeolite. Waste management (New York, N.Y.) 0 41633239
2026 Nanometric Faujasite (FAU) Zeolite Ion-Exchanged With Metal Ions for Hemostatic and Antimicrobial Applications: A Thromboelastographic and Microbiological Study. Chemistry, an Asian journal 0 42057284
2024 Investigating the regulatory mechanism of glucose metabolism by ubiquitin-like protein MNSFβ. Molecular biology reports 0 39404900
2016 Mn(2+)-Ion Site Distribution of Zeolite Y (FAU, Si/Al = 1.56) Depending on the Ion-Exchange Ratio. Journal of nanoscience and nanotechnology 0 27483785

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