Affinage

IGF2BP2

Insulin-like growth factor 2 mRNA-binding protein 2 · UniProt Q9Y6M1

Round 2 corrected
Length
599 aa
Mass
66.1 kDa
Annotated
2026-04-28
130 papers in source corpus 5 papers cited in narrative 5 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IGF2BP2 is an RNA-binding protein containing two RRM and four KH domains that regulates mRNA fate by binding target transcripts and modulating their stability and translation. Originally identified as a translational repressor of IGF-II leader 3 mRNA that localizes to subcytoplasmic granules in a growth-dependent manner (PMID:9891060), IGF2BP2 was subsequently shown to function as an N6-methyladenosine (m6A) reader that recognizes GG(m6A)C motifs via its KH domains, promoting stability and translational output of thousands of mRNA targets including MYC (PMID:29476152) and SOX2 (PMID:31230592). IGF2BP2 protein levels are regulated by TRIM25-mediated ubiquitination scaffolded by the circular RNA circNDUFB2, which promotes its proteasomal degradation (PMID:33436560).

Mechanistic history

Synthesis pass · year-by-year structured walk · 5 steps
  1. 1999 High

    The discovery that IGF2BP2 binds the 5′ UTR of IGF-II leader 3 mRNA and represses its translation established IGF2BP2 as a post-transcriptional regulator with defined RNA-binding domain architecture (two RRMs and four KH domains) and subcytoplasmic localization.

    Evidence RNA binding assays, luciferase reporter translational repression, immunofluorescence in multiple cell types and mouse embryos

    PMID:9891060

    Open questions at the time
    • Endogenous target repertoire beyond IGF-II mRNA was unknown
    • Mechanism of subcytoplasmic granule localization was not defined
    • Relative contributions of RRM versus KH domains to target selectivity were unresolved
  2. 2015 Medium

    A liver-specific overexpression model revealed that the IMP2-2/p62 splice variant of IGF2BP2 drives hepatocarcinogenesis through a DLK1–RAC1–NADPH oxidase–ROS axis, demonstrating that IGF2BP2 dysregulation has oncogenic consequences beyond direct translational control.

    Evidence Transgenic mouse liver overexpression, DEN-induced carcinogenesis, siRNA epistasis in HepG2 cells, ROS measurement

    PMID:26426686

    Open questions at the time
    • Findings are specific to the IMP2-2 splice variant; contribution of full-length IGF2BP2 to this pathway is unclear
    • Direct RNA targets mediating DLK1 upregulation were not identified
    • Whether the ROS-promoting activity operates via m6A-dependent mRNA stabilization was not tested
  3. 2018 High

    Genome-wide identification of IGF2BP2 as an m6A reader that recognizes GG(m6A)C motifs through its KH domains fundamentally reframed the protein from a single-target translational repressor to a broad mRNA stabilizer that enhances translation of thousands of targets including MYC.

    Evidence m6A-seq, PAR-CLIP, RNA immunoprecipitation, KH domain mutagenesis, polysome profiling, mRNA stability assays in cancer cell lines

    PMID:29476152

    Open questions at the time
    • Structural basis of m6A recognition by KH domains was not resolved
    • Context-dependent switching between translational repression and mRNA stabilization modes was not explained
    • Individual contributions of IGF2BP2 versus IGF2BP1/3 to shared target mRNAs were not fully delineated
  4. 2019 High

    Demonstration that IGF2BP2 stabilizes SOX2 mRNA by reading METTL3-deposited m6A marks in the coding sequence extended the m6A-reader model to a specific stemness-associated target in colorectal cancer, confirming the functional link between epitranscriptomic writing and IGF2BP2-mediated mRNA stabilization.

    Evidence MeRIP-seq, reciprocal RIP, RNA pull-down, RNA stability assay, knockdown/overexpression in CRC cell lines and PDX models

    PMID:31230592

    Open questions at the time
    • Whether IGF2BP2 binding to CDS m6A sites involves distinct recognition geometry compared to 3′ UTR sites was not addressed
    • Relative importance of IGF2BP2-SOX2 axis versus other m6A readers in maintaining stemness was not resolved
  5. 2021 Medium

    Discovery that circNDUFB2 scaffolds TRIM25-mediated ubiquitination and proteasomal degradation of IGF2BP2 revealed a regulatory layer controlling IGF2BP2 protein abundance, linking circular RNA biology and m6A modification to IGF2BP2 turnover.

    Evidence Co-immunoprecipitation, ubiquitination assays, protein stability assays, m6A modification analysis in NSCLC cell lines and mouse models

    PMID:33436560

    Open questions at the time
    • IGF2BP2-specific versus IGF2BP1/3 effects were not fully separated in this study
    • TRIM25 ubiquitination sites on IGF2BP2 were not mapped
    • Whether other E3 ligases regulate IGF2BP2 stability independently of circNDUFB2 is unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis for m6A recognition by IGF2BP2's KH domains, the rules governing context-dependent switching between translational repression and mRNA stabilization, and the full repertoire of physiological (non-oncogenic) functions of IGF2BP2 remain unresolved.
  • No crystal or cryo-EM structure of IGF2BP2 KH domains bound to m6A-containing RNA
  • Mechanism by which IGF2BP2 switches from translational repression (IGF-II) to mRNA stabilization (MYC, SOX2) is undefined
  • Physiological in vivo roles via conditional knockout models remain largely unexplored in the available literature

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 3 GO:0045182 translation regulator activity 2
Localization
GO:0005829 cytosol 1
Pathway
R-HSA-8953854 Metabolism of RNA 2 R-HSA-392499 Metabolism of proteins 1
Partners
METTL3TRIM25

Evidence

Reading pass · 5 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 IGF2BP2 (IMP2) belongs to a family of three IGF-II mRNA-binding proteins (IMPs/IGF2BP1/2/3) that bind the 5' UTR of IGF-II leader 3 mRNA through two RNA recognition motifs and four KH domains, causing dose-dependent translational repression of IGF-II leader 3 mRNA; the proteins localize to subcytoplasmic domains in a growth-dependent and cell-specific manner. RNA binding assays, luciferase reporter translational repression assay, subcellular localization by immunofluorescence, developmental expression profiling in mouse embryos Molecular and cellular biology High 9891060
2018 IGF2BP1/2/3 function as m6A readers that recognize the GG(m6A)C consensus sequence on thousands of mRNA targets via their KH domains; unlike YTHDF2, IGF2BPs promote mRNA stability and storage (e.g., MYC mRNA) in an m6A-dependent manner under normal and stress conditions, enhancing translation output. m6A-seq, PAR-CLIP, RNA immunoprecipitation, mRNA stability assays, KH domain mutagenesis, polysome profiling, loss-of-function in cancer cell lines Nature cell biology High 29476152
2019 IGF2BP2 acts downstream of METTL3-mediated m6A methylation to stabilize SOX2 mRNA by recognizing m6A marks in the coding sequence (CDS) region of SOX2 transcripts, preventing SOX2 mRNA degradation in colorectal carcinoma cells. MeRIP-seq, RNA immunoprecipitation, RNA pull-down, RNA stability assay, knockdown/overexpression in CRC cell lines and PDX models Molecular cancer High 31230592
2021 circNDUFB2 functions as a scaffold that enhances interaction between the E3 ubiquitin ligase TRIM25 and IGF2BP proteins (including IGF2BP2), forming a TRIM25/circNDUFB2/IGF2BPs ternary complex that promotes ubiquitination and proteasomal degradation of IGF2BPs; this effect is enhanced by m6A modification of circNDUFB2. Co-immunoprecipitation, ubiquitination assays, protein stability assays, m6A modification analysis, loss-of-function in NSCLC cell lines and mouse models Nature communications Medium 33436560
2015 IGF2BP2 was identified as an IMP2-2/p62 splice variant that, when overexpressed in mouse liver, promotes hepatocarcinogenesis through DLK1-dependent activation of RAC1 GTPase, stimulating NADPH oxidase and elevating reactive oxygen species production. Transgenic mouse overexpression, DEN-induced carcinogenesis model, aCGH, siRNA knockdown in HepG2 cells, ROS measurement, inflammatory cytokine profiling Cell death & disease Medium 26426686

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2018 Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nature cell biology 2381 29476152
2010 PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nature cell biology 2347 20098416
2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (New York, N.Y.) 2225 17463246
2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (New York, N.Y.) 2110 17463248
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2007 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (New York, N.Y.) 1702 17463249
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 1451 20881960
2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nature genetics 1435 18372903
2010 Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature genetics 1401 20581827
2016 ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell 1233 26777405
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2009 Monitoring autophagic degradation of p62/SQSTM1. Methods in enzymology 991 19200883
2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Molecular cell 973 22681889
2013 Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Molecular cell 969 24011591
2009 p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 938 19524504
2014 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature genetics 834 24509480
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2016 p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation. Cellular & molecular biology letters 757 28536631
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2015 p62/SQSTM1 functions as a signaling hub and an autophagy adaptor. The FEBS journal 669 26432171
2012 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature genetics 661 22581228
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2019 METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma. Molecular cancer 649 31230592
2008 Clinical risk factors, DNA variants, and the development of type 2 diabetes. The New England journal of medicine 636 19020324
1999 A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Molecular and cellular biology 610 9891060
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
2008 Genotype score in addition to common risk factors for prediction of type 2 diabetes. The New England journal of medicine 580 19020323
2008 SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nature genetics 548 18711366
2015 p62 links autophagy and Nrf2 signaling. Free radical biology & medicine 535 26117325
2017 Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.) 533 28302793
2021 circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity. Nature communications 478 33436560
2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature 445 25231870
2010 Physiological significance of selective degradation of p62 by autophagy. FEBS letters 445 20153326
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2011 p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Molecular cell 421 21981924
2018 p62 filaments capture and present ubiquitinated cargos for autophagy. The EMBO journal 297 29343546
2006 Signal integration and diversification through the p62 scaffold protein. Trends in biochemical sciences 278 17174552
2006 p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery. Autophagy 266 16874037
2012 p62/SQSTM1/A170: physiology and pathology. Pharmacological research 254 22841931
2018 p62/SQSTM1 - steering the cell through health and disease. Journal of cell science 232 30397181
2010 Selective degradation of p62 by autophagy. Seminars in immunopathology 212 20814791
2018 p62/SQSTM1: 'Jack of all trades' in health and cancer. The FEBS journal 206 30499183
2018 Autophagic Regulation of p62 is Critical for Cancer Therapy. International journal of molecular sciences 205 29738493
2016 TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Molecular cell 191 26942676
2014 Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proceedings of the National Academy of Sciences of the United States of America 190 24927592
2011 Autophagy and p62 in cardiac proteinopathy. Circulation research 163 21659648
2019 SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. Autophagy 152 31441382
2012 p62 at the interface of autophagy, oxidative stress signaling, and cancer. Antioxidants & redox signaling 151 22074114
2019 SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy. Autophagy 142 31339428
2006 Sequestosome 1/p62--more than just a scaffold. FEBS letters 140 17188686
2019 Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. Nature communications 131 31857589
2013 Interaction domains of p62: a bridge between p62 and selective autophagy. DNA and cell biology 128 23530606
2016 SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy 127 27391408
2019 p62/SQSTM1 and Selective Autophagy in Cardiometabolic Diseases. Antioxidants & redox signaling 123 30588824
1998 P62 and the sequestosome, a novel mechanism for protein metabolism. Archives of pharmacal research 121 9868528
2013 Role of p62/SQSTM1 in liver physiology and pathogenesis. Experimental biology and medicine (Maywood, N.J.) 119 23856904
2017 Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination. Cell reports 116 28380357
2014 P62/SQSTM1 at the interface of aging, autophagy, and disease. Age (Dordrecht, Netherlands) 116 24557832
2020 NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system. EMBO reports 105 31916398
2017 From autophagy to mitophagy: the roles of P62 in neurodegenerative diseases. Journal of bioenergetics and biomembranes 104 28975445
2020 The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction. Circulation research 94 32366200
2018 ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nature communications 90 30349045
2021 The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer. Biomedicines 83 34206503
2023 S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy. Molecular cell 79 37802024
2019 Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma. Oncogene 73 31444413
2015 IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype. Cell death & disease 73 26426686
2018 CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation. Cell death and differentiation 68 30154446
2014 Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy. FEBS letters 64 24492006
2014 The adaptor protein p62 is involved in RANKL-induced autophagy and osteoclastogenesis. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 63 25163928
2022 OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity. Autophagy 62 35100065
2017 VPS34 stimulation of p62 phosphorylation for cancer progression. Oncogene 62 28846113
2017 The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. The Journal of cell biology 61 28404643
2021 SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components. The Journal of cell biology 59 34037656
2020 Structure and function of p62/SQSTM1 in the emerging framework of phase separation. The FEBS journal 57 33332721
2009 The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts. Molecular endocrinology (Baltimore, Md.) 57 19589897
2022 Palmitoylation restricts SQSTM1/p62-mediated autophagic degradation of NOD2 to modulate inflammation. Cell death and differentiation 56 35066577
2019 Sequestosome-1 (p62) expression reveals chaperone-assisted selective autophagy in immune-mediated necrotizing myopathies. Brain pathology (Zurich, Switzerland) 54 31376301
2018 p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2. Molecular and cellular biology 52 30126895
2022 p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation. IUBMB life 51 36331376
2021 Hepatocytic p62 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagy. Journal of hepatology 49 34710483
2013 TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1. Molecular immunology 47 24270048
2021 TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins. Autophagy 44 34382902
2021 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review). International journal of oncology 44 34414460
2018 Role of p62 in the regulation of cell death induction. Apoptosis : an international journal on programmed cell death 44 29480462
2021 Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351. Scientific reports 43 33875681
2021 Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis. Cell death & disease 42 33854041
2015 P62/Ubiquitin IHC Expression Correlated with Clinicopathologic Parameters and Outcome in Gastrointestinal Carcinomas. Frontiers in oncology 42 25870850
2020 p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus Roles. International journal of molecular sciences 41 32708719
2018 Metabolic reprogramming of the tumor microenvironment by p62 and its partners. Biochimica et biophysica acta. Reviews on cancer 41 29702207
2023 Local membrane source gathering by p62 body drives autophagosome formation. Nature communications 39 37957156
2009 AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62. Hippocampus 38 19004011
2024 A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements. Science (New York, N.Y.) 36 39208097
2019 The Multifunctional Protein p62 and Its Mechanistic Roles in Cancers. Current cancer drug targets 36 30332964
2019 TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform. EMBO reports 35 31347268
2019 p62 acts as an oncogene and is targeted by miR-124-3p in glioma. Cancer cell international 35 31708690
2020 Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability. Aging cell 34 33146912
2016 p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies. PloS one 34 27526095
2023 LLPS of SQSTM1/p62 and NBR1 as outcomes of lysosomal stress response limits cancer cell metastasis. Proceedings of the National Academy of Sciences of the United States of America 33 37847732
2021 FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates. Scientific reports 33 34226595
2022 The dual role of p62 in ferroptosis of glioblastoma according to p53 status. Cell & bioscience 32 35216629
2016 Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. Journal of cell science 32 26743088
2023 The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway. Cell death and differentiation 31 37081115
2015 Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation. Biochemical and biophysical research communications 31 26282199
2019 G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10. Scientific reports 28 31501480
2017 GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis. Biochemical and biophysical research communications 28 29128363
2025 Phase separation of p62: roles and regulations in autophagy. Trends in cell biology 27 40011090
2024 S-acylation regulates SQSTM1/p62-mediated selective autophagy. Autophagy 27 38124295
2021 p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death. Scientific reports 27 34075102
2020 The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nature communications 27 32385399
2017 Autophagy regulates DNA repair through SQSTM1/p62. Autophagy 25 28650265
2019 p62/mTOR/LXRα pathway inhibits cholesterol efflux mediated by ABCA1 and ABCG1 during autophagy blockage. Biochemical and biophysical research communications 24 31101336
2023 Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy. Cell & bioscience 23 36810259
2020 Insight into the role of p62 in the cisplatin resistant mechanisms of ovarian cancer. Cancer cell international 23 32322174
2019 iNOS Interacts with Autophagy Receptor p62 and is Degraded by Autophagy in Macrophages. Cells 23 31618870
2022 Vault RNA1-1 riboregulates the autophagic function of p62 by binding to lysine 7 and arginine 21, both of which are critical for p62 oligomerization. RNA (New York, N.Y.) 22 35210358
2018 Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism. Cell reports 22 30231994
2024 Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment. Redox biology 21 39657365
2020 Pathogenesis of Human Papillomaviruses Requires the ATR/p62 Autophagy-Related Pathway. mBio 21 32788179
2024 PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity. Virologica Sinica 20 38272236
2023 The emerging potential role of p62 in cancer treatment by regulating metabolism. Trends in endocrinology and metabolism: TEM 20 37349161
2022 Acetylation of p62 regulates base excision repair through interaction with APE1. Cell reports 20 35858573
2020 SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12. iScience 20 32805647
2017 Tumor SQSTM1 (p62) expression and T cells in colorectal cancer. Oncoimmunology 20 28405513
2024 Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion. Science advances 19 38865459
2018 Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation. PloS one 19 30067838
2011 Autophagy and p62 in cardiac protein quality control. Autophagy 18 21997373