Affinage

SERBP1

SERPINE1 mRNA-binding protein 1 · UniProt Q8NC51

Length
408 aa
Mass
45.0 kDa
Annotated
2026-04-28
47 papers in source corpus 25 papers cited in narrative 25 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SERBP1 is an intrinsically disordered RNA-binding protein that constitutively associates with ribosomes and regulates mRNA translation, stability, and epitranscriptomic modification across diverse cellular contexts. Its RGG boxes mediate preferential binding to G-rich and G-quadruplex RNA sequences, and SERBP1 occupies both 40S and 60S ribosomal subunits—including the peptidyl transferase center of dormant ribosomes—where PKCε-dependent phosphorylation represses translation and drives mitotic ribonucleoprotein granule (M-body) formation required for chromosome segregation (PMID:34836941, PMID:30039520, PMID:34631798). SERBP1 undergoes PRMT1-mediated asymmetric arginine dimethylation that governs its cytoplasmic–nuclear/nucleolar shuttling and stress granule dynamics, and it promotes stress granule clearance by recruiting proteasome components and facilitating G3BP1 ubiquitination (PMID:22442049, PMID:24205981, PMID:37223481). Through mRNA stabilization, SERBP1 activates homologous recombination by sustaining CtIP and BRCA1 transcript levels in S phase, forms a complex with PCIF1 to deposit m6Am modifications on neuronal mRNAs, interacts with PARP1 in PARylation-dependent complexes linked to G-quadruplex biology, and bridges viral RNA to the ribosomal translation machinery via RACK1 during dengue virus infection (PMID:26068472, PMID:41856985, PMID:40764612, PMID:39937575, PMID:35266803).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2005 Medium

    Early work placed SERBP1 at the cell surface in ovarian cells, revealing an unexpected extracellular role in progesterone-mediated anti-apoptotic signaling through interaction with the membrane progesterone receptor PGRMC1.

    Evidence Immunocytochemistry on non-permeabilized living granulosa/luteal cells and antibody-blocking experiments with co-IP of PGRMC1

    PMID:15814896

    Open questions at the time
    • Mechanism downstream of PGRMC1–SERBP1 interaction undefined
    • No independent replication of cell-surface localization in other cell types
  2. 2006 Medium

    Yeast two-hybrid screening identified SERBP1 nuclear interactions with SUMO-pathway and chromatin-associated proteins (Daxx, PIAS family, TDG) and established its co-localization with Cajal bodies and nucleoli, broadening its functional landscape beyond the cytoplasm.

    Evidence Yeast two-hybrid screen with GFP/RFP co-localization in HeLa cells

    PMID:16679534

    Open questions at the time
    • No biochemical co-IP confirmation of yeast two-hybrid hits
    • Functional significance of Cajal body association unknown
  3. 2012 High

    Identification of PRMT1 as the methyltransferase that asymmetrically dimethylates SERBP1's RG/RGG regions established arginine methylation as a regulatory switch controlling SERBP1's cytoplasmic versus nuclear/nucleolar distribution.

    Evidence Recombinant PRMT1 in vitro methylation assay, PRMT1 siRNA reducing aDMA, immunofluorescence with AdOx treatment

    PMID:22442049

    Open questions at the time
    • Specific arginine residues methylated not fully mapped
    • Downstream functional consequences of hypomethylation on translation not tested
  4. 2013 High

    Building on the methylation findings, SERBP1 was shown to interact with stress granule components (hnRNP A1, FMRP, FXR1) and to partition between stress granules and the nucleolus upon arsenite stress, with arginine methylation status controlling the kinetics of this partitioning.

    Evidence Co-IP with RNase treatment, arsenite/AdOx perturbation, TIA-1 co-localization immunofluorescence

    PMID:24205981

    Open questions at the time
    • Whether SERBP1 is required for SG formation vs. merely recruited was unresolved
    • RNA targets within SGs not identified
  5. 2013 Medium

    The SPINDLIN1–SERBP1 ribonucleoprotein complex was found to regulate PDE3A mRNA levels and meiotic resumption in mouse oocytes, providing the first evidence that SERBP1-containing complexes control specific mRNA targets in germ cell biology.

    Evidence Co-IP of SPIN1–SERBP1, Spin1 conditional KO in oocytes with PDE3A mRNA readout

    PMID:23894536

    Open questions at the time
    • Direct RNA-binding by SERBP1 to PDE3A mRNA not demonstrated
    • Single study without independent replication
  6. 2015 High

    RIP-seq and polysome profiling established SERBP1 as a translational regulator of CtIP mRNA in S phase, directly linking SERBP1 to homologous recombination-mediated DNA repair through its RGG-dependent RNA-binding activity.

    Evidence RIP-seq, polysome profiling, ΔRGG rescue experiments with HR readouts (CHK1/RPA2 phosphorylation)

    PMID:26068472

    Open questions at the time
    • Whether SERBP1 regulates CtIP mRNA stability vs. translation initiation not fully dissected
    • Genome-wide scope of SERBP1-regulated HR transcripts unknown
  7. 2017 Medium

    Mapping the SERBP1–RACK1 interaction to SERBP1's C-terminal domain and showing overlap with the PDE4D5 binding site on RACK1 established a competitive interaction model on the ribosomal scaffold protein.

    Evidence Yeast two-hybrid with domain deletion and RACK1 point mutant mapping

    PMID:28267599

    Open questions at the time
    • No in-cell co-IP confirmation
    • Functional consequence of PDE4D5 competition not tested
  8. 2018 High

    Biochemical fractionation and mass spectrometry definitively placed SERBP1 on the 40S ribosomal subunit and within polysomes, establishing it as a constitutive ribosome-associated factor.

    Evidence Ultracentrifugation, MS of rodent testis ribosomes, polysome cosedimentation after subunit dissociation

    PMID:30039520

    Open questions at the time
    • Structural basis of 40S binding unknown at this time
    • Whether ribosome association is RNA-dependent not resolved
  9. 2020 High

    In glioblastoma, SERBP1 was shown to bind GC-rich RNA motifs and regulate metabolic gene networks controlling methionine production, linking SERBP1-dependent translation to epigenetic reprogramming via H3K27me3.

    Evidence RNAcompete motif identification, SERBP1 KD in GBM/glioma stem cells, metabolomics, ChIP-seq, RNA-seq

    PMID:32762776

    Open questions at the time
    • Direct mRNA targets mediating methionine regulation not individually validated
    • Whether this metabolic circuit operates outside GBM unclear
  10. 2021 High

    Two studies together resolved SERBP1's biophysical nature and its mitotic function: NMR confirmed it is intrinsically disordered and binds G-rich RNA via its RGG boxes with capacity for liquid–liquid phase separation, while PKCε phosphorylation of SERBP1 was shown to repress translation, alter 40S binding, and drive M-body assembly required for chromosome segregation.

    Evidence NMR spectroscopy and LLPS assays (PMID:34631798); UV-crosslinker substrate trapping, ribosome binding assays, live imaging, SERBP1 KD chromosome segregation phenotype (PMID:34836941)

    PMID:34631798 PMID:34836941

    Open questions at the time
    • Phosphorylation sites on SERBP1 targeted by PKCε not fully mapped
    • Whether M-body formation requires LLPS of SERBP1 specifically not tested
    • Relationship between G4-binding and phase separation not explored
  11. 2022 High

    Multiple studies expanded SERBP1's functional repertoire: it was shown to bridge dengue viral RNA to ribosomes via RACK1, to modulate miRNA-dependent repression through Ago2/RISC association, and to scaffold transcriptional repressors CHD3/KAP1 at the HCMV MIEP during latency.

    Evidence RACK1 interactome MS, SERBP1 KO and RACK1-binding mutant rescue for DENV (PMID:35266803); Ago2 Co-IP/MS and KCC2 reporter assays (PMID:35326503); siRNA KD with ChIP at MIEP for HCMV (PMID:36504797)

    PMID:35266803 PMID:35326503 PMID:36504797

    Open questions at the time
    • How SERBP1 is recruited to RISC mechanistically unknown
    • Whether CHD3/KAP1 scaffolding is direct or RNA-mediated not resolved
    • Generality of the RACK1–SERBP1 axis beyond dengue not tested
  12. 2023 High

    SERBP1 was established as an active promoter of stress granule clearance by recruiting proteasome components (PSMD10, PSMA3) and facilitating K63-linked ubiquitination of G3BP1, resolving the earlier question of whether SERBP1 is merely a stress granule resident or plays a functional role in their dynamics.

    Evidence Co-IP of SERBP1 with G3BP1/proteasome subunits, 20S proteasome activity assay, ubiquitination assay, SERBP1 KO with heat-stress germ cell apoptosis phenotype

    PMID:37223481

    Open questions at the time
    • Whether proteasome recruitment is direct or via an adaptor unknown
    • Mechanism linking SG clearance defect to germ cell apoptosis not molecularly defined
  13. 2024 Medium

    SERBP1 acetylation was identified as a regulatory modification: KSHV-induced SIRT3-mediated deacetylation disrupts SERBP1 binding to Lipt2 mRNA, leading to ferroptosis suppression and viral transformation, adding acetylation alongside methylation and phosphorylation as post-translational controls.

    Evidence Acetylation proteomics, SIRT3 inhibitor treatment, mRNA stability and ferroptosis assays

    PMID:38470932

    Open questions at the time
    • Specific acetylated residues on SERBP1 not mapped
    • Whether SERBP1 acetylation regulates non-viral mRNA targets unknown
    • Single study
  14. 2025 High

    Multiple high-impact studies converged to provide structural, epitranscriptomic, and physiological depth: cryo-EM revealed SERBP1 bound at the peptidyl transferase center of dormant ribosomes and bridging 40S–60S subunits in situ; SERBP1–PCIF1 complex was shown to deposit m6Am on neuronal mRNAs controlling neuropathic pain; SERBP1 stabilizes BRCA1 mRNA activating RAD51-mediated HR; interactome mapping linked SERBP1 to PARP1 and G4-binding protein networks; and conditional knockout in oocytes established SERBP1 as essential for oocyte growth, meiotic spindle assembly, and female fertility.

    Evidence In situ cryo-EM at 2.19 Å (preprint); 1.72 Å cryo-EM of 60S dormant state (preprint); SERBP1–PCIF1 Co-IP with m6Am-seq and neuronal KD (PMID:40764612); BRCA1 mRNA stability and xenograft epistasis (PMID:41856985); AP-MS interactome with PARylation assays (PMID:39937575); Zp3/Gdf9-Cre conditional KO with spindle/fertility phenotype (PMID:40902969)

    PMID:39937575 PMID:40764612 PMID:40902969 PMID:41856985 PMID:bio_10.1101_2024.07.02.601723 PMID:bio_10.1101_2025.10.11.680285

    Open questions at the time
    • Structural mechanism by which SERBP1 gates translation initiation vs. elongation not resolved
    • How PCIF1–SERBP1 complex selects specific mRNA targets for m6Am unknown
    • Relationship between SERBP1's ribosomal and nuclear/nucleolar functions not integrated

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include how SERBP1's multiple post-translational modifications (methylation, phosphorylation, acetylation, PARylation) are coordinated to switch it between ribosomal, stress granule, and nuclear functions; the full structural basis of SERBP1's ribosome binding across translational states; and whether SERBP1's G-quadruplex recognition underlies a unified target-selection logic across its diverse mRNA substrates.
  • No integrated PTM crosstalk study exists
  • In situ cryo-EM findings are preprints awaiting peer review
  • G4-dependent target selection not systematically tested genome-wide

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 4 GO:0005198 structural molecule activity 4 GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005730 nucleolus 4 GO:0005840 ribosome 4 GO:0005634 nucleus 3 GO:0005829 cytosol 3
Pathway
R-HSA-392499 Metabolism of proteins 5 R-HSA-8953854 Metabolism of RNA 3 R-HSA-1640170 Cell Cycle 2 R-HSA-73894 DNA Repair 2 R-HSA-8953897 Cellular responses to stimuli 2
Partners
AGO2G3BP1PARP1PCIF1PGRMC1PRMT1RACK1SPIN1
Complex memberships
SERBP1–G3BP1–proteasome SG clearance complexSERBP1–PCIF1 m6Am writer complexSERBP1–RACK1 ribosomal complex

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2012 SERBP1 is asymmetrically dimethylated on arginines in its RG and RGG regions by PRMT1; this arginine methylation regulates cytoplasmic/nuclear distribution, with hypomethylation causing nuclear/nucleolar retention. Co-immunoprecipitation of endogenous PRMT1 with SERBP1, recombinant PRMT1 in vitro methylation assay, PRMT1 siRNA knockdown reducing aDMA levels, immunofluorescence of deletion constructs with AdOx treatment Journal of cellular biochemistry High 22442049
2013 Under normal conditions, SERBP1 interacts with arginine-methylated and stress granule-associated proteins (hnRNP A1, FMRP, FXR1) in an RNA-dependent manner; upon arsenite stress, a proportion of SERBP1 co-localizes with TIA-1-positive cytoplasmic stress granules while another fraction concentrates in the nucleolus. Hypomethylation (via AdOx) retains SERBP1 in the nucleus/nucleolus and delays its association/dissociation with stress granules. Co-immunoprecipitation, immunofluorescence with deletion constructs, arsenite and AdOx treatment, co-localization with TIA-1 stress granule marker The FEBS journal High 24205981
2015 SERBP1 binds CtIP mRNA during S phase and promotes its translation, thereby regulating CtIP protein levels required for homologous recombination-mediated DNA repair after double-strand breaks. An RNA-binding defective mutant (SERBP1 ΔRGG) fails to rescue CtIP expression. RNA immunoprecipitation-coupled RNA sequencing (RIP-seq), polysome profiling, SERBP1 knockdown with rescue using wild-type vs. ΔRGG mutant, CHK1 and RPA2 phosphorylation as HR readouts Nucleic acids research High 26068472
2017 SERBP1 interacts selectively with RACK1 via its C-terminal third (which contains one PRMT1 substrate site); this interaction surface on RACK1 substantially overlaps with the binding site for PDE4D5. Yeast two-hybrid screen, beta-galactosidase interaction assay with SERBP1 isoforms and deletion constructs, reverse two-hybrid screen with RACK1 point mutants Cellular signalling Medium 28267599
2018 Mammalian SERBP1 localizes to the nucleolus and cytoplasm; cytoplasmic SERBP1 pellets by ultracentrifugation and is identified by proteomic analysis as a component of the 40S ribosomal subunit that co-sediments with polysomes (translating ribosomes). Subcellular fractionation, ultracentrifugation, mass spectrometry of rodent testis ribosomes, polysome profiling with cosedimentation after subunit dissociation Cell biochemistry and function High 30039520
2020 SERBP1 binds GC-rich RNA motifs and regulates metabolic gene networks in glioblastoma, including genes controlling methionine production; SERBP1 knockdown reduces methionine levels and consequently decreases H3K27me3 histone methylation, upregulating neurogenesis/differentiation genes. RNAcompete binding motif identification, SERBP1 knockdown in GBM and glioma stem cell lines, metabolomics, ChIP-seq for H3K27me3, RNA-seq Genome biology High 32762776
2021 SERBP1 is a substrate of PKCε; PKCε phosphorylation of SERBP1 represses protein translation, alters SERBP1 binding to the 40S ribosomal subunit, and promotes assembly of ribonucleoprotein granules (M-bodies) during mitosis. SERBP1 is required for chromosome segregation and successful cell division independently of Aurora B. UV-photocrosslinkable amino acid trapping in PKCε kinase domain (genetically encoded crosslinker screen), validation of SERBP1 as PKCε substrate, ribosome binding assays, live imaging of M-body formation, SERBP1 KD with chromosome segregation readout Nature communications High 34836941
2021 SERBP1 is an intrinsically disordered protein that lacks canonical RNA-binding motifs; it preferentially binds G-rich RNA sequences via its C-terminal RGG box and neighboring residues. SERBP1 undergoes liquid-liquid phase separation mediated by salt and RNA, requiring both RGG boxes for efficient condensate formation. Solution NMR, biophysical binding assays, truncation analysis, LLPS assay Frontiers in molecular biosciences High 34631798
2022 SERBP1 associates with RACK1 and the dengue virus (DENV) RNA genome and facilitates DENV replication by linking the viral RNA to the translation machinery at the 40S ribosomal subunit; a SERBP1 mutant lacking RACK1 binding but retaining viral RNA interaction is unable to support DENV infection. RACK1 interactome mass spectrometry, RNA interference screen, genetic ablation of SERBP1, SERBP1 mutant lacking RACK1 binding domain, viral translation/replication assays Journal of virology High 35266803
2022 SERBP1 interacts with Argonaute2 (Ago2) and is present in the RISC complex; SERBP1 silencing attenuates miR-92-mediated repression of the KCC2 3'UTR in neuronal cells, indicating SERBP1 modulates miRNA-dependent translational repression. Co-immunoprecipitation of Ago2 followed by LC-MS/MS identification of SERBP1, RIP demonstrating SERBP1 and Ago2/miR-92 binding to KCC2 3'UTR, SERBP1 siRNA knockdown with luciferase reporter assays Cells Medium 35326503
2022 SERBP1 is upregulated during HCMV latency and functions as a scaffold protein to recruit transcriptional repressors CHD3 and KAP1 to the viral major immediate early promoter (MIEP), mediating epigenetic silencing of the MIEP during latent infection. siRNA knockdown of SERBP1 in latently infected myeloid cells, ChIP assay for CHD3 and KAP1 at the MIEP, quantitative RT-PCR for MIEP activity Frontiers in microbiology Medium 36504797
2023 SERBP1 promotes stress granule (SG) clearance by interacting with the SG core component G3BP1 and 26S proteasome proteins (PSMD10 and PSMA3), recruiting them to SGs; SERBP1 absence reduces 20S proteasome activity, mislocalizes VCP/FAF2, and diminishes K63-linked polyubiquitination of G3BP1 during SG disassembly. SERBP1 depletion in testicular cells increases germ cell apoptosis upon heat stress. Co-immunoprecipitation of SERBP1 with G3BP1, PSMD10, PSMA3; proteasome activity assay; ubiquitination assay; SERBP1 KO in testicular cells with heat stress phenotype Research (Washington, D.C.) High 37223481
2024 KSHV-encoded vIL-6 promotes SIRT3-mediated deacetylation of SERBP1; when deacetylated, SERBP1 fails to bind and protect Lipt2 mRNA from degradation, leading to ferroptosis suppression and enhanced KSHV-induced cellular transformation. Acetylation proteomics, SIRT3 inhibitor (3-TYP) treatment, SERBP1 deacetylation assay, mRNA stability assay for Lipt2, ferroptosis assays, cellular transformation assays PLoS pathogens Medium 38470932
2025 SERBP1 interacts with PARP1 and participates in PARylation-dependent protein complexes; SERBP1 influences PARylation levels, while PARylation in turn modulates SERBP1 function and complex membership. SERBP1 preferentially interacts with G-quadruplex (G4)-binding proteins across multiple stages of gene expression and is present in Tau aggregates in Alzheimer's brains. Interactome mapping (AP-MS), PARylation assays, G4-binding partner analysis, immunofluorescence in Alzheimer's brain tissue, splicing and ribosome biogenesis functional assays eLife Medium 39937575
2025 SERBP1 forms a complex with PCIF1 that mediates m6Am mRNA modification; in glutamatergic neurons of the primary somatosensory cortex, the SERBP1-PCIF1 complex deposits m6Am on Maf1 mRNA, reducing MAF1 protein levels and contributing to neuropathic pain and anxiety. Co-immunoprecipitation of SERBP1-PCIF1 complex, m6Am-seq to map modification sites, conditional knockdown in specific neuron populations, behavioral assays for neuropathic pain/anxiety, viral vector-mediated expression Nature communications High 40764612
2025 SERBP1 stabilizes BRCA1 mRNA, thereby activating RAD51-mediated homologous recombination repair; this SERBP1-BRCA1 axis confers cisplatin resistance in lung adenocarcinoma, and BRCA1 knockdown abrogates SERBP1-driven resistance both in vitro and in vivo. Gain/loss-of-function experiments, mRNA stability assay for BRCA1, RAD51 foci assay, BRCA1 KD epistasis in xenograft model Cell death discovery Medium 41856985
2006 CGI-55 (SERBP1) interacts with Daxx, Topors, PIASy, UBA2, TDG, and PIAS1/3 in the nucleus and co-localizes with p80-coilin-positive nuclear Cajal bodies and the nucleolus, but not prominently with PML nuclear bodies. Yeast two-hybrid screen, in vivo co-localization by GFP/RFP fusion proteins in HeLa cells, domain mapping of binding sites Cell biochemistry and biophysics Medium 16679534
2015 SERBP1 is a component of the LRH1 (liver receptor homologue-1) transcriptional complex; LRH1 binds the SERBP1 promoter and represses SERBP1 transcription, while LRH1 knockdown increases SERBP1 expression. Nuclear fractionation followed by mass spectrometry and Western blot to identify LRH1-interacting partners, LRH1 siRNA knockdown, promoter:reporter luciferase assay Journal of proteome research Medium 26398198
2013 SPINDLIN1 (SPIN1) interacts with SERBP1 via its Tudor-like domain to form a ribonucleoprotein complex that regulates mRNA stability and/or translation; this complex controls PDE3A mRNA levels and is required for meiotic resumption in mouse oocytes. Co-immunoprecipitation of SPIN1 with SERBP1, Spin1 conditional knockout in mouse oocytes with meiotic phenotype, PDE3A mRNA quantification PloS one Medium 23894536
2024 SYT1 binds and stabilizes SERBP1 protein, which in turn enhances GLUT2 mRNA stability; this SYT1-SERBP1-GLUT2 axis promotes PQ efflux and protects kidney cells from paraquat toxicity. Immunoprecipitation-shotgun proteomics identifying SYT1-SERBP1 interaction, RNA interference of SERBP1, Western blot and mRNA stability assay for GLUT2 Chemico-biological interactions Medium 39059605
2005 SERBP1 (PAIRBP1) localizes to the extracellular surface of granulosa and luteal cells and mediates progesterone's antiapoptotic action; immunoprecipitation with SERBP1 antibody co-pulls down PGRMC1, suggesting SERBP1 functions in a complex with this membrane progesterone-binding protein. Immunocytochemistry on non-permeabilized living cells, SERBP1 antibody blocking of P4 antiapoptotic action, immunoprecipitation pulling down PGRMC1 Biology of reproduction Medium 15814896
2026 SERBP1 binds parallel G-quadruplex (G4) RNA and DNA structures with low micromolar affinity via its RGG box in an encircling mechanism; phosphomimetic mutations of C-terminal serine residues reduce G4 binding affinity, identifying phosphorylation as a regulatory switch. SERBP1 regulates mTOR expression in glioblastoma through G4 elements in the mTOR 5' UTR, and SERBP1 depletion synergizes with mTOR inhibition to reduce cell growth. NMR spectroscopy, biophysical binding assays, molecular dynamics and docking simulations, phosphomimetic mutagenesis, SERBP1 depletion in GBM cells with mTOR expression and growth readouts bioRxivpreprint Medium 41846982
2025 In situ cryo-EM of human cells reveals that SERBP1 binds to the ribosome in almost all translating and non-translating states, bridging the 60S and 40S ribosomal subunits at multiple binding sites not observed on purified ribosomes. In situ cryo-EM of intact human cells using cryo-FIB milling and single-particle analysis (2.19 Å consensus structure with 21 functional states) bioRxivpreprint Medium bio_10.1101_2024.07.02.601723
2025 Cryo-EM at 1.72 Å of human 60S ribosome identifies SERBP1 bound at the peptidyl transferase center in a dormant, non-translating ribosome state, consistent with SERBP1 occupying the mRNA channel of non-translating ribosomes. High-resolution cryo-EM of human ribosomes in cell-free translation lysate bioRxivpreprint Medium bio_10.1101_2025.10.11.680285
2025 SERBP1 is required for oocyte growth and meiotic competence in mice; conditional Serbp1 knockout causes arrested oocyte growth, spindle assembly defects, impaired asymmetric division, granulosa cell apoptosis, and elevated ERK1/2 phosphorylation, leading to female infertility. Conditional knockout using Zp3/Gdf9-Cre drivers, spindle assembly immunofluorescence, ERK1/2 phosphorylation Western blot, phenotypic analysis of oocyte development and fertility Molecular and cellular endocrinology High 40902969

Source papers

Stage 0 corpus · 47 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation. Genome biology 81 32762776
2005 Expression and function of PAIRBP1 within gonadotropin-primed immature rat ovaries: PAIRBP1 regulation of granulosa and luteal cell viability. Biology of reproduction 68 15814896
2017 MiR-218 suppresses the metastasis and EMT of HCC cells via targeting SERBP1. Acta biochimica et biophysica Sinica 61 28369267
2007 Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: association with tumor progression. Gynecologic oncology 46 17698176
2013 Localization of SERBP1 in stress granules and nucleoli. The FEBS journal 44 24205981
2012 Protein arginine methylation of SERBP1 by protein arginine methyltransferase 1 affects cytoplasmic/nuclear distribution. Journal of cellular biochemistry 42 22442049
2013 Expression of progesterone receptor membrane component (PGRMC) 1 and 2, serpine mRNA binding protein 1 (SERBP1) and nuclear progesterone receptor (PGR) in the bovine endometrium during the estrous cycle and the first trimester of pregnancy. Reproductive biology 40 23522067
2016 Loss of miR-26a-5p promotes proliferation, migration, and invasion in prostate cancer through negatively regulating SERBP1. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 39 27449037
2015 SERBP1 affects homologous recombination-mediated DNA repair by regulation of CtIP translation during S phase. Nucleic acids research 35 26068472
2018 The mRNA-binding protein Serbp1 as an auxiliary protein associated with mammalian cytoplasmic ribosomes. Cell biochemistry and function 33 30039520
2022 RACK1 Associates with RNA-Binding Proteins Vigilin and SERBP1 to Facilitate Dengue Virus Replication. Journal of virology 28 35266803
2013 A tudor domain protein SPINDLIN1 interacts with the mRNA-binding protein SERBP1 and is involved in mouse oocyte meiotic resumption. PloS one 28 23894536
2006 CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus. Cell biochemistry and biophysics 27 16679534
2021 Structural Characterization of the RNA-Binding Protein SERBP1 Reveals Intrinsic Disorder and Atypical RNA Binding Modes. Frontiers in molecular biosciences 25 34631798
2017 Dynamic expression of PGRMC1 and SERBP1 in human endometrium: an implication in the human decidualization process. Fertility and sterility 23 28911927
2023 SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage. Research (Washington, D.C.) 21 37223481
2022 SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation. Cell death & disease 21 35387981
2012 Differential expression of PAI-RBP1, C1orf142, and COTL1 in non-small cell lung cancer cell lines with different tumor metastatic potential. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 21 22373659
2021 CircRNA circBACH1 (hsa_circ_0061395) serves as a miR-656-3p sponge to facilitate hepatocellular carcinoma progression through increasing SERBP1 expression. Biochemical and biophysical research communications 20 33831787
2017 The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1. Cellular signalling 20 28267599
2021 A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division. Nature communications 19 34836941
2021 miR-362-3p acts as a tumor suppressor by targeting SERBP1 in ovarian cancer. Journal of ovarian research 17 33526047
2020 lncRNA TMPO-AS1 Exerts Oncogenic Roles in HCC Through Regulating miR-320a/SERBP1 Axis. OncoTargets and therapy 17 32753892
2014 Ki-1/57 and CGI-55 ectopic expression impact cellular pathways involved in proliferation and stress response regulation. Biochimica et biophysica acta 17 25205453
2024 KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation. PLoS pathogens 14 38470932
2019 Complex interactomes and post-translational modifications of the regulatory proteins HABP4 and SERBP1 suggest pleiotropic cellular functions. World journal of biological chemistry 13 31768228
2016 Expression of Progesterone Receptor Membrane Component 1 (PGRMC1), Progestin and AdipoQ Receptor 7 (PAQPR7), and Plasminogen Activator Inhibitor 1 RNA-Binding Protein (PAIRBP1) in Glioma Spheroids In Vitro. BioMed research international 13 27340667
2022 Latency-associated upregulation of SERBP1 is important for the recruitment of transcriptional repressors to the viral major immediate early promoter of human cytomegalovirus during latent carriage. Frontiers in microbiology 11 36504797
2023 miR-145 Modulates Fatty Acid Metabolism by Targeting FOXO1 to Affect SERBP1 Activity in Bovine Mammary Epithelial Cells. Journal of agricultural and food chemistry 10 37154263
2022 Silencing of Ago-2 Interacting Protein SERBP1 Relieves KCC2 Repression by miR-92 in Neurons. Cells 8 35326503
2022 SERBP1 affects the apoptotic level by regulating the expression and alternative splicing of cellular and metabolic process genes in HeLa cells. PeerJ 8 36213507
2021 Circ_0046600 promotes hepatocellular carcinoma progression via up-regulating SERBP1 through sequestering miR-1258. Pathology, research and practice 7 34784519
2015 SERBP1 Is a Component of the Liver Receptor Homologue-1 Transcriptional Complex. Journal of proteome research 7 26398198
2021 The 1H, 15N and 13C resonance assignments of the C-terminal domain of Serpine mRNA binding protein 1 (SERBP1). Biomolecular NMR assignments 4 34436734
2025 SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis. eLife 3 39937575
2024 Avian leukosis virus usurps the cellular SERBP1 protein to enhance its transcription and promote productive infections in avian cells. Poultry science 3 38663206
2025 The 1H, 15N and 13C backbone resonance assignments of the N-terminal (1-149) domain of Serpine mRNA Binding Protein 1 (SERBP1). Biomolecular NMR assignments 2 40153110
2025 "SERBP1 (Hero45) is a Novel Link with Ischemic Heart Disease Risk: Associations with Coronary Arteries Occlusion, Blood Coagulation and Lipid Profile". Cell biochemistry and biophysics 2 40175693
2025 SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice. Nature communications 2 40764612
2025 Clinical and immunohistochemical effects of OncoTherad (MRB-CFI-1) nanoimmunotherapy on SERBP1, HABP4, CD44 and Ki-67 in BCG-unresponsive non-muscle invasive bladder cancer. Tissue & cell 1 39938427
2025 RNA binding protein SERBP1 is indispensable for oocyte development and maturation in mice. Molecular and cellular endocrinology 1 40902969
2024 SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis. bioRxiv : the preprint server for biology 1 38585848
2026 Intrinsically disordered SERBP1 regulates translation through topology-driven G-quadruplex recognition. bioRxiv : the preprint server for biology 0 41846982
2026 SERBP1 is required for efficient HR repair and cisplatin chemoresistance in lung adenocarcinoma. Cell death discovery 0 41856985
2025 Dual molecular axis of resistance and immunoresponsiveness to BCG in pT1 non-muscle invasive bladder cancer: Insights from HER-2, SERBP1, HABP4, and IFN-γ profiling. Tissue & cell 0 40967126
2025 Super-enhancer-driven ELOVL5 promotes T-ALL progression through the MYC-SERBP1 pathway. Genomics 0 41016515
2024 Synaptotagmin-1 antagonizes paraquat intracellular accumulation and nephrocyte toxicity by up-regulating SERBP1/GLUT2 expression. Chemico-biological interactions 0 39059605