Affinage

STAU1

Double-stranded RNA-binding protein Staufen homolog 1 · UniProt O95793

Length
577 aa
Mass
63.2 kDa
Annotated
2026-04-28
40 papers in source corpus 20 papers cited in narrative 21 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

STAU1 is a double-stranded RNA-binding protein that serves as a central post-transcriptional regulator of mRNA fate, controlling mRNA decay, stabilization, nuclear export, translation, and alternative splicing in a context-dependent manner. STAU1 mediates mRNA decay (SMD) by recognizing dsRNA structures—including intermolecular Alu-element duplexes formed between target 3' UTRs and trans-acting lncRNAs—in partnership with UPF1, while it stabilizes specific mRNAs (BACE1, PTEN, BECN1, Dvl2, SIRT1) by binding their 3' UTRs independently of the decay pathway (PMID:21307942, PMID:39764852, PMID:38729552, PMID:22166206). STAU1 promotes mRNA translation by binding 5' UTR structures to recruit eIF4A3 or by forming cytoplasmic condensates that enhance mTOR mRNA translation, and it facilitates nuclear export of IRAlus-containing mRNAs while blocking PKR-mediated translational repression (PMID:38913026, PMID:23824540, PMID:38577609). STAU1 abundance is regulated by APC/C- and TRIM25-mediated ubiquitin-dependent degradation through a defined FPL degron motif, and its functional mode is switched from decay-promoting to mRNA-stabilizing upon interaction with glucose-responsive DDX50 monomers, linking metabolic state to post-transcriptional gene regulation (PMID:36232890, PMID:39764852).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2008 Medium

    Establishing that STAU1 has post-transcriptional roles beyond canonical SMD, its knockdown in myoblasts promoted myogenesis by upregulating myogenin independently of UPF1, revealing a UPF1-independent differentiation-regulatory function.

    Evidence siRNA knockdown of Stau1 vs Upf1 in C2C12 myoblasts with myogenin expression readout

    PMID:18422603

    Open questions at the time
    • Mechanism by which STAU1 represses myogenin independently of UPF1 not defined
    • Direct binding to myogenin mRNA not demonstrated
    • Single cell model
  2. 2011 High

    The discovery that lncRNA-derived Alu elements base-pair with Alu elements in target mRNA 3' UTRs to create STAU1-binding sites (SBSs) established the first trans-acting RNA mechanism for triggering SMD, explaining how STAU1 is recruited to mRNAs lacking intramolecular dsRNA structures.

    Evidence RNA-seq, RIP, reporter assays, and siRNA knockdown identifying lncRNA (½-sbsRNA)-mRNA Alu duplexes

    PMID:21307942

    Open questions at the time
    • Structural basis of STAU1 recognition of imperfect Alu duplexes not resolved
    • Genome-wide scope of functional ½-sbsRNAs remains incomplete
  3. 2011 Medium

    Demonstrating that STAU1 can stabilize rather than degrade mRNAs, binding to Dvl2 3' UTR extended its half-life in undifferentiated myoblasts, and dissociation during differentiation permitted Dvl2 downregulation—establishing the mRNA-stabilizing arm of STAU1 function.

    Evidence RIP, mRNA half-life assay, and reporter assays with Dvl2 3' UTR in C2C12 cells

    PMID:22166206

    Open questions at the time
    • Determinants distinguishing stabilization-mode vs decay-mode binding not identified
    • Single target in one cell type
  4. 2012 Medium

    Identifying STAU1 as a component of a TDP-43/FMRP/STAU1 complex that stabilizes SIRT1 mRNA revealed STAU1 can act cooperatively with other RNA-binding proteins to stabilize specific transcripts.

    Evidence Co-IP, RIP, RNA pull-down, and siRNA knockdown measuring SIRT1 mRNA/protein levels

    PMID:22584570

    Open questions at the time
    • Stoichiometry and direct contacts within the tripartite complex unknown
    • Whether other mRNAs are jointly regulated not explored
  5. 2013 High

    Demonstrating that STAU1 binding to IRAlus promotes nuclear export and enhances translation by excluding PKR from 3' UTRs established STAU1 as a dual regulator of mRNA localization and translational competence.

    Evidence Nuclear/cytoplasmic fractionation, RIP, reporter assays, eIF2α phosphorylation measurements upon STAU1/PKR knockdown

    PMID:23824540

    Open questions at the time
    • Export receptor or adaptor mediating STAU1-dependent nuclear export not identified
    • Whether all IRAlus-containing mRNAs are equally affected is unclear
  6. 2016 Medium

    The finding that lncRNA SNHG5 protects specific mRNAs from STAU1-mediated decay by competitive binding demonstrated that lncRNAs can inhibit (not just activate) SMD, adding a regulatory layer to STAU1 target selection.

    Evidence RNA interactome capture, double-knockdown epistasis rescue, and mRNA stability assay in colorectal cancer cells

    PMID:28004750

    Open questions at the time
    • Binding site overlap between SNHG5 and STAU1 on target mRNAs not mapped at nucleotide resolution
    • Generality to other lncRNAs not tested
  7. 2018 Medium

    Showing that STAU1 competes with MDA5 for viral dsRNA binding to suppress IFN-β induction demonstrated a proviral innate immune-evasion function for STAU1's dsRNA-binding activity.

    Evidence In vitro binding, Co-IP, IFN-β reporter assay with domain-deletion mutants during IBDV infection

    PMID:29979632

    Open questions at the time
    • Relevance to other dsRNA viruses not established
    • Whether STAU1 is actively co-opted by the virus or is a general consequence of dsRNA binding unclear
  8. 2021 Medium

    Revealing that STAU1 stabilizes autophagy mRNAs (BECN1, ATG16L1) in cancer cells but its depletion activates mTOR-dependent autophagy in non-transformed muscle cells established cell-type-specific and opposing roles for STAU1 in autophagy regulation.

    Evidence mRNA stability assays, siRNA knockdown, and STAU1-transgenic mouse skeletal muscle analysis with autophagy and mTOR markers

    PMID:33899158

    Open questions at the time
    • Molecular determinants underlying cell-type-specific STAU1 behavior not defined
    • Relative contribution of direct mRNA stabilization vs indirect JNK/DUSP8 pathway unclear
  9. 2022 Medium

    Mapping the FPL degron (aa 38–50) and identifying APC/C and TRIM25 as E3 ligases for STAU1 degradation defined the ubiquitin-dependent turnover mechanism controlling STAU1 abundance during mitosis and beyond.

    Evidence Alanine scanning mutagenesis, protein stability assays, BioID proximity labeling, Co-IP

    PMID:36232890

    Open questions at the time
    • Ubiquitylation sites on STAU1 not mapped
    • Cell-cycle-dependent regulation of TRIM25-mediated degradation not explored
  10. 2022 Medium

    Demonstrating that phosphomimicry at S20 impairs STAU1-mediated translation and decay and induces apoptosis—even via a minimal N-terminal fragment acting in trans—revealed a phosphorylation-based regulatory switch and a dominant-negative mechanism.

    Evidence Site-directed mutagenesis, reporter assays for translation and decay, apoptosis assays with truncation mutants

    PMID:35806349

    Open questions at the time
    • Kinase phosphorylating S20 in vivo not identified
    • Mechanism of trans-dominant inhibition by the 88-aa fragment not resolved
  11. 2024 High

    Discovering that endogenous STAU1 forms cytoplasmic condensates that recruit mTOR mRNA at its 5' UTR to promote translation linked STAU1 phase behavior to mTOR signaling and autophagy-lysosome function, with excessive condensation driving pathology in neurodegeneration models.

    Evidence Live-cell imaging, in vitro translation, STAU1 knockdown/overexpression, autophagic flux assays in HD knockin striatal cells

    PMID:38913026

    Open questions at the time
    • Biophysical properties (material state, composition) of STAU1 condensates not fully characterized
    • Whether condensate-mediated translation applies to targets beyond mTOR unknown
  12. 2024 Medium

    Demonstrating STAU1 stabilizes BACE1 mRNA and enhances GADD45B/P38-dependent Tau phosphorylation connected STAU1 overabundance to both amyloidogenesis and tauopathy cascades in Alzheimer's disease models.

    Evidence RIP, mRNA half-life assay, transcriptome analysis, Western blot for Aβ and phospho-Tau

    PMID:38729552

    Open questions at the time
    • Whether STAU1-BACE1 axis is causal in human AD pathology not established
    • GADD45B regulation mechanism (direct binding vs indirect) not clarified
  13. 2025 High

    Identifying the DDX50-STAU1 functional switch resolved how STAU1 is reprogrammed from decay-promoting (UPF1-associated) to mRNA-stabilizing (DDX50-associated) mode in response to glucose, explaining context-dependent target stabilization during differentiation.

    Evidence Co-IP, RIP, RNA structure probing, mRNA stability assays, glucose binding assay across multiple cell types

    PMID:39764852

    Open questions at the time
    • Structural basis of competitive DDX50 vs UPF1 binding to STAU1 not determined
    • Full repertoire of mRNAs redirected by the DDX50-STAU1 switch not cataloged
  14. 2025 Medium

    Showing that STAU1 depletion inhibits p53-mediated apoptosis across multiple neuronal and non-neuronal systems positioned STAU1 as a required effector in p53-driven pro-apoptotic signaling.

    Evidence Transcriptomics and functional assays in iPSC-derived neurons, cortical neurons, SH-SY5Y cells, fibroblasts, and C9orf72 mouse model with Nutlin-3/etoposide treatment

    PMID:41145462

    Open questions at the time
    • Whether STAU1 directly regulates p53 mRNA or acts on downstream p53 target mRNAs not resolved
    • Mechanism linking STAU1 to p53 pathway activation not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • The molecular determinants that specify whether STAU1 binding to a given mRNA leads to decay, stabilization, or translational enhancement remain undefined, as does the structural basis for STAU1 condensate formation and its regulation.
  • No target-intrinsic code distinguishing decay vs stabilization substrates
  • No high-resolution structure of STAU1 in complex with physiological dsRNA substrates
  • Kinase(s) for S20 phosphorylation unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 13 GO:0098772 molecular function regulator activity 4 GO:0045182 translation regulator activity 3
Localization
GO:0005829 cytosol 4 GO:0005634 nucleus 2
Pathway
R-HSA-8953854 Metabolism of RNA 5 R-HSA-392499 Metabolism of proteins 4 R-HSA-9612973 Autophagy 4 R-HSA-5357801 Programmed Cell Death 2 R-HSA-74160 Gene expression (Transcription) 2
Partners
DDX50EIF4A3FMRPMDA5PKRTARDBPTRIM25UPF1

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 STAU1-binding sites on target mRNAs can be formed by imperfect base-pairing between Alu elements in the 3' UTR of SMD target mRNAs and complementary Alu elements in cytoplasmic polyadenylated lncRNAs (termed 1/2-sbsRNAs), enabling lncRNAs to transactivate STAU1-mediated mRNA decay (SMD) of specific targets. RNA-seq, RNA immunoprecipitation, reporter assays, siRNA knockdown, identification of lncRNA-mRNA Alu duplex formation Nature High 21307942
2013 STAU1 binding to inverted repeat Alu elements (IRAlus) in 3' UTRs of mRNAs inhibits nuclear retention of those mRNAs and augments their nuclear export; additionally, 3' UTR IRAlus-bound STAU1 enhances translation by precluding PKR binding, thereby preventing eIF2α phosphorylation and global translational shutdown. RNA immunoprecipitation, fractionation (nuclear/cytoplasmic), reporter assays, siRNA knockdown of STAU1/PKR, measurement of eIF2α phosphorylation Genes & development High 23824540
2012 TDP-43 physically associates with FMRP and STAU1 to form a functional complex that binds the 3' UTR of SIRT1 mRNA and stabilizes it; knockdown of any one of the three components reduces SIRT1 mRNA and protein levels. Co-immunoprecipitation, RNA immunoprecipitation (RIP), RNA pull-down, microarray, siRNA knockdown The Journal of biological chemistry Medium 22584570
2008 Stau1 negatively regulates myogenic differentiation in C2C12 myoblasts; Stau1 knockdown increases myogenin mRNA and protein levels and promotes myogenesis, while Upf1 knockdown does not, indicating that Stau1's role in myogenesis is mechanistically distinct from canonical SMD. siRNA knockdown, RT-PCR, Western blot, myogenin promoter reporter assay in C2C12 cells Genes to cells Medium 18422603
2011 Stau1 binds to the 3' UTR of Dvl2 mRNA and stabilizes it in undifferentiated C2C12 myoblasts; Stau1 knockdown shortens Dvl2 mRNA half-life, and during myogenic differentiation the Stau1-Dvl2 mRNA association decreases, causing Dvl2 downregulation that enables differentiation. RNA immunoprecipitation, mRNA half-life assay, reporter assay with Dvl2 3' UTR, siRNA knockdown, Dvl2 overexpression Biochemical and biophysical research communications Medium 22166206
2018 STAU1 binds IBDV genomic double-stranded RNA via its N-terminal moiety (residues 1-468) and promotes viral replication by competing with MDA5 for dsRNA binding, thereby attenuating MDA5-dependent IFN-β induction; a C-terminal STAU1 mutant (469-702) lacking dsRNA binding failed to suppress IFN-β. In vitro binding assay, co-immunoprecipitation, reporter assay (IFN-β promoter), siRNA knockdown/overexpression, domain-deletion mutants FASEB journal Medium 29979632
2016 The lncRNA SNHG5 stabilizes target mRNAs (e.g., SPATS2) by blocking their STAU1-mediated degradation in colorectal cancer cells; STAU1 depletion rescues apoptosis caused by SNHG5 knockdown, placing STAU1 downstream of SNHG5 in this pathway. Unbiased RNA interactome capture, siRNA knockdown, mRNA stability assay, genetic epistasis (double knockdown rescue), in vivo xenograft Nature communications Medium 28004750
2022 STAU1 is degraded by the E3 ubiquitin ligase APC/C during mitosis; the degradation motif was mapped to amino acids 38-50 (FPL-motif: F39PxPxxLxxxxL50), and alanine scanning mutations of this motif prevent APC/C-mediated STAU1 degradation. Additionally, TRIM25, an E3 ubiquitin ligase, was identified by proximity labeling as responsible for STAU1 and MAP4K1 degradation via the FPL-motif. Alanine scanning mutagenesis, protein stability assay, proximity labeling (BioID), co-immunoprecipitation International journal of molecular sciences Medium 36232890
2022 Phosphomimicry at STAU1 serine 20 (S20D mutation) impairs STAU1-mediated mRNA translation and decay regulation and is sufficient to induce apoptosis in cancer cells; even the N-terminal 88-amino-acid fragment RBD2S20D (lacking RNA-binding activity) induces apoptosis by acting in trans on endogenous STAU1's posttranscriptional functions. Site-directed mutagenesis, reporter assays for translation/decay, apoptosis assays, overexpression of truncation mutants International journal of molecular sciences Medium 35806349
2024 Endogenous STAU1 forms dynamic cytoplasmic condensates; these condensates recruit MTOR mRNA at its 5' UTR and promote mTOR translation both in vitro and in vivo. Excessive STAU1 condensate formation leads to mTOR hyperactivation and autophagy-lysosome dysfunction in neurodegenerative disease models. Live-cell imaging of condensates, in vitro translation assay, STAU1 knockdown/overexpression, mTOR activity and autophagic flux assays, Huntington's disease knockin striatal cells The Journal of cell biology High 38913026
2023 STAU1 regulates alternative splicing of Pparγ2 pre-mRNA during adipocyte differentiation, primarily through exon skipping (exon E1 of Pparγ2); STAU1 binds Pparγ2 pre-mRNA as shown by RIP and PAR-CLIP. RNA-seq (alternative splicing analysis), RNA immunoprecipitation, PAR-CLIP, sucrose density gradient centrifugation, siRNA knockdown in 3T3-L1 cells Biochimica et biophysica acta. Molecular and cell biology of lipids Medium 36871938
2022 STAU1 indirectly binds the HBV core promoter (CP) mediated by TARDBP, and recruits the SAGA transcription coactivator complex to upregulate CP activity; STAU1 also binds HBx protein and stabilizes HBx in a ubiquitin-independent manner. TurboID proximity labeling, co-immunoprecipitation, ChIP, reporter assay, siRNA knockdown iScience Medium 35663023
2021 STAU1 depletion in alveolar rhabdomyosarcoma cells reduces autophagy by directly destabilizing BECN1 and ATG16L1 mRNAs and indirectly inhibiting JNK signaling via increased DUSP8 expression; pharmacological JNK activation or DUSP8 silencing restores autophagy in STAU1-depleted cells. siRNA knockdown, mRNA stability assay, Western blot for autophagy markers, pharmacological rescue (JNK activator), STAU1-transgenic mouse skeletal muscle Cellular oncology Medium 33899158
2024 STAU1 stabilizes BACE1 mRNA by binding to its 3' UTR, thereby extending BACE1 mRNA half-life and promoting amyloidogenesis; additionally, STAU1 enhances GADD45B expression, which activates P38 MAPK signaling to promote Tau phosphorylation at Ser396 and Thr181. RIP, mRNA half-life assay, siRNA knockdown/overexpression, transcriptome analysis, Western blot for BACE1, Aβ, and phospho-Tau Experimental neurology Medium 38729552
2025 DDX50 monomers (generated upon glucose binding) bind STAU1 and redirect it from a decay-promoting complex with UPF1 to a DDX50-STAU1 ribonuclear complex that stabilizes pro-differentiation mRNAs (JUN, OVOL1, CEBPB, PRDM1, TINCR) and modifies their RNA structures. Co-immunoprecipitation, RNA immunoprecipitation, RNA structure probing, mRNA stability assay, glucose binding assay, knockdown/overexpression in multiple cell types Cell reports High 39764852
2024 STAU1 directly binds the 3' UTR of PTEN mRNA to stabilize it; in the context of GIGYF2-mediated insulin resistance, elevated STAU1 stabilizes PTEN mRNA, leading to AKT inactivation and impaired PI3K/AKT signaling. RNA immunoprecipitation (RIP), siRNA knockdown, Western blot, glucose uptake assay, high-fat diet mouse model Molecular medicine Medium 39138413
2025 STAU1 reduction inhibits p53-mediated apoptosis and DNA damage responses; combined transcriptomic and functional analyses in iPSC-derived neurons, mouse cortical neurons, SH-SY5Y cells, fibroblasts, and C9orf72 mouse models showed that STAU1 depletion prevents p53-driven pro-apoptotic signaling (Nutlin-3 and etoposide treatment models). Transcriptomic analysis, siRNA/RNAi knockdown, Nutlin-3 and etoposide treatment, multiple cell types including iPSC-derived neurons and C9orf72 mouse model Cell death & disease Medium 41145462
2025 tRF-3019A competitively binds STAU1 protein with BECN1 mRNA, thereby releasing BECN1 mRNA from STAU1-mediated destabilization and enhancing BECN1 stable expression to promote autophagy and colon cancer progression. RNA pull-down, RNA immunoprecipitation, GFP-LC3B assay, siRNA knockdown, xenograft tumor model Cellular signalling Medium 40268078
2024 circ-231 promotes interaction between eIF4A3 and STAU1; STAU1 binds secondary structures in the 5' UTR of TPI1 and PRDX6 mRNAs and recruits eIF4A3 to unwind these structures, enhancing translation of these proteins. RNA immunoprecipitation, RNA pull-down, mass spectrometry, co-immunoprecipitation, EGFP reporter assay with 5' UTR secondary structure, siRNA knockdown Journal of Cancer Medium 38577609
2026 The lncRNA lnc-APUE promotes CDH1 mRNA decay via an Alu element in lnc-APUE base-pairing with the Alu element in the CDH1 3' UTR, triggering STAU1-mediated mRNA decay (SMD) requiring both STAU1 and UPF1; silencing STAU1 or UPF1 abrogates lnc-APUE-induced CDH1 mRNA decay and E-cadherin loss. Alu deletion/mutation constructs, siRNA knockdown of STAU1 and UPF1, mRNA stability assay, mouse xenograft model, RIP Advanced science Medium 41632098
2021 STAU1 stabilizes BECN1 and ATG16L1 mRNAs in alveolar rhabdomyosarcoma cells; in non-transformed skeletal muscle cells, STAU1 downregulation activates autophagy in an mTOR-dependent manner, demonstrating cell-type-specific opposing roles for STAU1 in autophagy regulation. siRNA knockdown, STAU1-transgenic mouse skeletal muscle fractionation, mRNA stability assay, Western blot for mTOR and autophagy markers Cellular oncology Medium 33899158

Source papers

Stage 0 corpus · 40 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Nature 1016 21307942
2016 SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization. Nature communications 170 28004750
2013 STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown. Genes & development 111 23824540
2017 E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis. Cell death & disease 99 28569791
2012 Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells. The Journal of biological chemistry 60 22584570
2020 PABPC1-induced stabilization of BDNF-AS inhibits malignant progression of glioblastoma cells through STAU1-mediated decay. Cell death & disease 57 32015336
2020 lncRNA LINC00665 Stabilized by TAF15 Impeded the Malignant Biological Behaviors of Glioma Cells via STAU1-Mediated mRNA Degradation. Molecular therapy. Nucleic acids 56 32464546
2020 The PABPC5/HCG15/ZNF331 Feedback Loop Regulates Vasculogenic Mimicry of Glioma via STAU1-Mediated mRNA Decay. Molecular therapy oncolytics 29 32346611
2018 STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 29979632
2020 IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay. RNA biology 25 32713259
2021 LncCCLM inhibits lymphatic metastasis of cervical cancer by promoting STAU1-mediated IGF-1 mRNA degradation. Cancer letters 24 34273467
2008 Stau1 negatively regulates myogenic differentiation in C2C12 cells. Genes to cells : devoted to molecular & cellular mechanisms 20 18422603
2011 Stau1 regulates Dvl2 expression during myoblast differentiation. Biochemical and biophysical research communications 16 22166206
2020 STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway. Oncology reports 14 33000283
1996 Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization. Genomics 14 8884277
2024 Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration. The Journal of cell biology 13 38913026
2021 Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non-transformed skeletal muscle cells. Cellular oncology (Dordrecht, Netherlands) 13 33899158
2021 Stress Granule-Mediated Oxidized RNA Decay in P-Body: Hypothetical Role of ADAR1, Tudor-SN, and STAU1. Frontiers in molecular biosciences 13 34150849
2022 Identification of STAU1 as a regulator of HBV replication by TurboID-based proximity labeling. iScience 12 35663023
2024 RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade. Molecular medicine (Cambridge, Mass.) 11 39138413
2025 PLAGL2-STAU1-NCOA4 axis enhances gastric cancer peritoneal metastasis by resisting ferroptosis via ferritinophagy. Apoptosis : an international journal on programmed cell death 7 39987411
2023 STAU1 promotes adipogenesis by regulating the alternative splicing of Pparγ2 mRNA. Biochimica et biophysica acta. Molecular and cell biology of lipids 7 36871938
2022 PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation. Gene 7 34990795
2020 The dynamic transmission of positional information in stau- mutants during Drosophila embryogenesis. eLife 7 32511091
2000 Genomic organization of the human and mouse stau genes. DNA and cell biology 7 10882232
2024 STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells. Experimental neurology 6 38729552
2023 Effects of STAU1/staufen1 on autophagy in neurodegenerative diseases. Autophagy 6 36652469
2024 STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer. Biology direct 4 39080743
2025 Knockdown of STAU1 inhibits inflammation and autophagy in in vitro chronic obstructive pulmonary disease model by regulating AMPK-mTOR signaling pathway. Allergologia et immunopathologia 3 39786888
2022 Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells. International journal of molecular sciences 3 35806349
2022 A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation. International journal of molecular sciences 3 36232890
2025 tRF-3019A/STAU1/BECN1 axis promotes autophagy and malignant progression of colon cancer. Cellular signalling 2 40268078
2024 circular RNA circ-231 promotes protein biogenesis of TPI1 and PRDX6 through mediating the interaction of eIF4A3 with STAU1 to facilitate unwinding of secondary structure in 5' UTR, enhancing progression of human esophageal squamous cell carcinoma (ESCC). Journal of Cancer 2 38577609
2025 DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs. Cell reports 1 39764852
2019 Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents. Molecular biology reports 1 30689188
2026 CCAT1 attenuates intermittent hypoxia associated endothelial cell pyroptosis through STAU1-mediated IRF1 mRNA degradation. Biochimica et biophysica acta. Molecular basis of disease 0 41520738
2026 TGFβ1 Activates Lnc-APUE to Promote Tumor Metastasis via the Alu Element-Driven STAU1-Mediated Decay of CDH1 mRNA. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 41632098
2026 STAU1-mediated stabilization of ITGB5 enhances FOXP3 transcriptional activity to form a self-reinforcing metastasis circuit in colorectal cancer. Cancer letters 0 41796846
2025 Targeting STAU1 prevents p53 apoptotic signaling in neurodegeneration. Cell death & disease 0 41145462
2008 Characterization of a novel transcript variant of human STAU1 gene. Acta biochimica Polonica 0 18806890