Affinage

STAU1

Double-stranded RNA-binding protein Staufen homolog 1 · UniProt O95793

Length
577 aa
Mass
63.2 kDa
Annotated
2026-06-10
41 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

STAU1 is a double-stranded RNA-binding protein that acts as a bidirectional post-transcriptional regulator, determining whether bound mRNAs are degraded or stabilized depending on its partner complexes (PMID:21307942, PMID:39764852). In its canonical decay role, STAU1 binds dsRNA structures in 3' UTRs—including those formed in trans by imperfect base-pairing between an Alu element in a target 3' UTR and a complementary Alu in a cytoplasmic lncRNA—and recruits UPF1 to trigger Staufen-mediated mRNA decay (SMD) (PMID:21307942, PMID:41632098). This SMD activity destabilizes targets such as CDH1 and Ucp1, with the latter linking STAU1 to adipose thermogenesis under β3-adrenergic/cAMP-PKA control (PMID:42242623, PMID:41632098). Conversely, STAU1 stabilizes numerous transcripts by 3' UTR binding—BACE1, PTEN, and Dvl2 among them—and can be redirected away from the UPF1 decay complex into a DDX50-STAU1 complex that stabilizes pro-differentiation mRNAs, reversing its SMD function (PMID:22166206, PMID:38729552, PMID:39138413, PMID:39764852). STAU1 binding to inverted-repeat Alu elements additionally augments nuclear export of those mRNAs and blocks PKR access to the dsRNA, preventing PKR-mediated eIF2α phosphorylation and global translational repression (PMID:23824540). Through dynamic cytoplasmic condensates STAU1 recruits MTOR mRNA at its 5' UTR to promote mTOR translation, such that STAU1 overabundance drives mTOR hyperactivation and autophagy-lysosome dysfunction (PMID:38913026, PMID:36652469). STAU1 abundance is itself controlled by APC/C- and TRIM25-mediated proteasomal degradation via an FPL-motif and is functionally modulated by phosphorylation at serine 20 (PMID:36232890, PMID:35806349). STAU1 overabundance promotes p53-driven apoptosis in neuronal disease models including C9orf72-expanded ALS, where its reduction is protective (PMID:41145462).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2008 Medium

    Established that Staufen has an mRNA-regulatory role in cell-fate decisions independent of its known decay cofactor, showing it is not solely an SMD effector.

    Evidence siRNA knockdown in C2C12 myoblasts with myogenin reporter and genetic dissection from Upf1

    PMID:18422603

    Open questions at the time
    • Direct mRNA targets mediating the myogenic phenotype not defined in this study
    • Upf1-independent molecular mechanism not resolved
  2. 2011 High

    Revealed that STAU1 decay sites can be assembled in trans by Alu-Alu base-pairing between a target 3' UTR and a cytoplasmic lncRNA, explaining how SMD targets are specified without a perfect cis stem-loop.

    Evidence Reciprocal RNA co-IP, reporter assays, and siRNA knockdown identifying 1/2-sbsRNA Alu pairing

    PMID:21307942

    Open questions at the time
    • Genome-wide scope of trans-acting lncRNA-directed SMD not enumerated
    • Structural basis of imperfect duplex recognition not defined
  3. 2011 Medium

    Demonstrated that STAU1 can stabilize rather than degrade a 3' UTR-bound transcript (Dvl2), and that this binding is developmentally regulated, foreshadowing STAU1's dual decay/stabilization output.

    Evidence RIP and reporter mRNA half-life assays in differentiating C2C12 cells

    PMID:22166206

    Open questions at the time
    • What switches STAU1 between stabilizing and decay modes not addressed
    • Single 3' UTR construct
  4. 2012 Medium

    Placed STAU1 in a multiprotein RNP with TDP-43 and FMRP that stabilizes a specific target (SIRT1), establishing partner-dependent stabilization with an apoptosis-relevant readout.

    Evidence Co-IP, reciprocal RIP, RNA pulldown, and knockdown with apoptosis assays

    PMID:22584570

    Open questions at the time
    • Stoichiometry and assembly order of the TDP-43/FMRP/STAU1 complex unknown
    • Single lab
  5. 2013 High

    Showed STAU1 binding to 3' UTR inverted-repeat Alus serves a dual gatekeeping function—promoting nuclear export and excluding PKR to prevent eIF2α-mediated translational shutdown.

    Evidence Nuclear/cytoplasmic fractionation, reporter assays, co-IP, and eIF2α phosphorylation assays

    PMID:23824540

    Open questions at the time
    • Competition kinetics between STAU1 and PKR for IRAlus not quantified
    • Single lab
  6. 2018 Medium

    Defined STAU1 as a direct dsRNA-binding antagonist of innate immune sensing, mapping the activity to its N-terminal moiety that competes with MDA5 for viral dsRNA.

    Evidence In vitro binding, deletion-mutant overexpression, and IFN-β promoter reporter assays in an IBDV system

    PMID:29979632

    Open questions at the time
    • Relevance to mammalian antiviral responses not established
    • Residues mediating MDA5 competition not pinpointed
  7. 2022 Medium

    Identified how STAU1 abundance is set, mapping an FPL degron targeted by APC/C during mitosis and by TRIM25, providing a degradative control point on STAU1 activity.

    Evidence Alanine-scanning mutagenesis, cycloheximide chase, proximity labeling, and proteasome inhibition

    PMID:36232890

    Open questions at the time
    • Physiological triggers for TRIM25-mediated turnover unclear
    • Single lab
  8. 2022 Medium

    Established phosphorylation at serine 20 as a functional switch on STAU1's post-transcriptional output, with a phosphomimetic N-terminal fragment acting in trans to induce apoptosis.

    Evidence S20D phosphomimetic mutagenesis, polysome profiling, mRNA stability and apoptosis assays in cancer cells

    PMID:35806349

    Open questions at the time
    • Kinase responsible for S20 phosphorylation not identified
    • Mechanism of dominant-negative trans action of the RBD2 fragment unresolved
  9. 2022 Medium

    Extended STAU1 function beyond RNA decay to transcriptional coactivation, showing it bridges TDP-43 to the SAGA complex at a viral promoter and stabilizes HBx protein.

    Evidence TurboID proximity labeling, co-IP, ChIP, and reporter assays in an HBV system

    PMID:35663023

    Open questions at the time
    • Generality of STAU1 promoter recruitment to host genes unknown
    • Single lab
  10. 2023 Medium

    Defined a STAU1-mTOR translational axis, showing STAU1 binds the MTOR 5' UTR to boost mTOR translation and impair autophagy, with reduction protective in ALS models.

    Evidence 5' UTR binding assays, mTOR-pathway western blots, and STAU1 reduction in ALS mouse models

    PMID:36652469

    Open questions at the time
    • Mechanism of 5' UTR-driven translational enhancement not resolved
    • Single lab
  11. 2023 Medium

    Implicated STAU1 in alternative splicing regulation, showing it binds Pparγ2 pre-mRNA to control exon usage and adipocyte differentiation.

    Evidence RIP, PAR-CLIP, and RNA-seq with knockdown/overexpression in 3T3-L1 adipocytes

    PMID:36871938

    Open questions at the time
    • Mechanism by which STAU1 influences spliceosome choice unknown
    • Nuclear versus cytoplasmic site of action not delineated
  12. 2024 High

    Demonstrated that STAU1 forms dynamic cytoplasmic condensates that physically organize MTOR mRNA translation, mechanistically linking STAU1 condensation to mTOR hyperactivation and autophagy-lysosome dysfunction.

    Evidence Live-cell condensate imaging, in vitro translation assays, in vivo mouse models, and functional rescue by condensate interference

    PMID:38913026

    Open questions at the time
    • Molecular determinants of STAU1 condensate assembly not fully mapped
    • Single lab
  13. 2024 Medium

    Defined disease-relevant 3' UTR stabilization targets, showing STAU1 extends BACE1 and PTEN mRNA half-lives to drive amyloidogenesis/tauopathy and hepatic insulin resistance respectively.

    Evidence RIP, mRNA half-life assays, pathway western blots, and in vivo mouse models

    PMID:38729552 PMID:39138413

    Open questions at the time
    • What directs STAU1 to stabilize rather than degrade these 3' UTRs not resolved
    • Single lab per target
  14. 2025 Medium

    Resolved the molecular basis of STAU1's decay-versus-stabilization switch, showing glucose-induced DDX50 monomers redirect STAU1 from the UPF1 decay complex into a stabilizing RNP for pro-differentiation mRNAs.

    Evidence Co-IP, CLIP-seq, mRNA stability assays, and in vitro reconstitution of the DDX50-STAU1 complex

    PMID:39764852

    Open questions at the time
    • Quantitative partitioning between UPF1 and DDX50 complexes in vivo not defined
    • Single lab
  15. 2025 Medium

    Connected STAU1 abundance to p53-dependent apoptosis, showing STAU1 reduction blunts pro-apoptotic and DNA-damage signaling in neurons and C9orf72-ALS models with baseline STAU1 overabundance.

    Evidence RNAi, transcriptomics, Nutlin-3/etoposide apoptosis assays, and patient fibroblast and C9orf72 mouse models

    PMID:41145462

    Open questions at the time
    • Direct link between STAU1 RNA targets and p53 activation not established
    • Single lab
  16. 2026 Medium

    Extended STAU1's SMD and stabilization activities into cancer metastasis, showing trans Alu-directed CDH1 decay promotes metastasis and 3' UTR stabilization of ITGB5 feeds a STAU1-ITGB5-FOXP3 feedback loop.

    Evidence RIP, Alu mutagenesis reporters, ChIP, STAU1/UPF1 knockdown, and xenograft/metastasis models

    PMID:41632098 PMID:41796846

    Open questions at the time
    • ITGB5/FOXP3 loop lacks reconstitution or mutagenesis validation (Low-confidence)
    • Tissue-specific selection of decay versus stabilization targets unresolved
  17. 2026 Medium

    Established STAU1 as a metabolic regulator of thermogenesis, showing it degrades Ucp1 mRNA via SMD under β3-adrenergic/cAMP-PKA control, with adipose-specific deletion enhancing thermogenesis.

    Evidence RIP, adipose-specific Stau1 knockout mice, metabolic phenotyping, and pharmacological pathway manipulation

    PMID:42242623

    Open questions at the time
    • How cAMP-PKA mechanistically lowers STAU1 not defined
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved what general molecular logic—partner availability, phosphorylation, condensation, or RNA structure—dictates whether STAU1 degrades, stabilizes, exports, or translationally promotes any given transcript in a physiological context.
  • No unified model integrating UPF1/DDX50 partitioning, S20 phosphorylation, and condensation
  • Genome-wide rules for target-fate determination not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 10 GO:0045182 translation regulator activity 3 GO:0140098 catalytic activity, acting on RNA 3 GO:0060090 molecular adaptor activity 2
Localization
GO:0005829 cytosol 2
Pathway
R-HSA-9612973 Autophagy 4 R-HSA-5357801 Programmed Cell Death 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-168256 Immune System 1 R-HSA-392499 Metabolism of proteins 1
Partners
DDX50FMR1GIGYF2MDA5TARDBPTRIM25UPF1
Complex memberships
DDX50-STAU1 ribonucleoproteinSTAU1 cytoplasmic condensatesSTAU1-UPF1 SMD complexTDP-43/FMRP/STAU1 complex

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 STAU1-binding sites on target mRNAs can be formed by imperfect base-pairing between an Alu element in the 3' UTR of an SMD target mRNA and a complementary Alu element in a cytoplasmic polyadenylated lncRNA (named 1/2-sbsRNA), thereby transactivating STAU1-mediated mRNA decay (SMD) in trans. RNA co-immunoprecipitation, reporter assays, siRNA knockdown, identification of Alu-element base-pairing between lncRNAs and target 3' UTRs Nature High 21307942
2013 STAU1 binding to inverted repeat Alu elements (IRAlus) in the 3' UTR of mRNAs inhibits nuclear retention, augmenting nuclear export of IRAlus-containing mRNAs, and also precludes PKR binding to those dsRNA structures, thereby preventing PKR-mediated eIF2α phosphorylation and global translational repression. siRNA knockdown, nuclear/cytoplasmic fractionation, reporter assays, co-immunoprecipitation, eIF2α phosphorylation assays Genes & development High 23824540
2012 TDP-43 physically associates with FMRP and STAU1 to form a functional complex that binds the 3' UTR of SIRT1 mRNA (demonstrated by RIP and RNA pulldown), stabilizing SIRT1 mRNA; knockdown of any one of the three proteins reduces SIRT1 mRNA and protein and sensitizes cells to apoptosis. Co-immunoprecipitation, RNA immunoprecipitation (RIP), RNA pulldown, siRNA knockdown, microarray The Journal of biological chemistry Medium 22584570
2008 Stau1 negatively regulates myogenic differentiation in C2C12 myoblasts; Stau1 knockdown increases myogenin mRNA and protein levels and promotes spontaneous myogenesis, through a mechanism independent of its co-factor Upf1 (Upf1 knockdown did not affect myogenesis). siRNA knockdown in C2C12 cells, RT-PCR, western blot, myogenin promoter reporter assay, immunofluorescence Genes to cells Medium 18422603
2011 Stau1 binds the 3' UTR of Dvl2 mRNA and stabilizes it in undifferentiated C2C12 myoblasts; Stau1 knockdown shortens the half-life of Dvl2 3' UTR-containing reporter mRNA, and association of Stau1 with Dvl2 3' UTR decreases upon induction of myogenic differentiation, correlating with reduced Dvl2 mRNA levels. RNA immunoprecipitation, mRNA half-life assay (reporter with Dvl2 3' UTR), siRNA knockdown, RT-PCR, western blot Biochemical and biophysical research communications Medium 22166206
2018 STAU1 directly binds IBDV genomic double-stranded RNA via its N-terminal moiety (residues 1–468); this binding decreases MDA5 association with viral dsRNA in vitro, attenuating MDA5-dependent IFN-β induction and promoting IBDV replication. A binding-deficient mutant (residues 469–702) failed to suppress IFN-β promoter activity. In vitro binding assay, co-immunoprecipitation, IFN-β promoter reporter assay, siRNA knockdown, overexpression of deletion mutants FASEB journal Medium 29979632
2022 STAU1 protein levels are downregulated during mitosis by the E3 ubiquitin ligase APC/C; the degradation determinant was mapped to a short FPL-motif (F39PxPxxLxxxxL50) by alanine scanning, and mutation of this motif prevents APC/C-mediated STAU1 degradation. Additionally, TRIM25 (an E3 ubiquitin ligase) was identified by proximity labeling as responsible for degrading STAU1 and MAP4K1 in a FPL-motif-dependent manner. Alanine scanning mutagenesis, cycloheximide chase, proximity labeling (BioID), proteasome inhibitor assays, mass spectrometry International journal of molecular sciences Medium 36232890
2022 Phosphomimicry at STAU1 serine 20 (S20D mutation) impairs STAU1-mediated translational regulation and mRNA decay, triggers apoptosis in cancer cells, and alters proliferation; even the isolated N-terminal 88-amino-acid fragment (RBD2S20D, lacking RNA-binding activity) induces apoptosis by acting in trans on endogenous STAU1 posttranscriptional functions. Site-directed mutagenesis (S20D phosphomimetic), overexpression in cancer cell lines, apoptosis assays, polysome profiling, mRNA stability assays International journal of molecular sciences Medium 35806349
2024 Endogenous STAU1 forms dynamic cytoplasmic condensates; these condensates recruit MTOR mRNA at its 5' UTR and promote mTOR translation both in vitro and in vivo. Excessive STAU1 condensate formation leads to mTOR hyperactivation and autophagy-lysosome dysfunction, and interference with condensate formation normalizes mTOR levels and restores autophagic flux. Live-cell imaging of condensates, in vitro translation assay, in vivo mouse models, STAU1 overexpression/knockdown, autophagy flux assays, mTOR pathway western blot The Journal of cell biology High 38913026
2023 STAU1 overexpression in HEK293 cells increases mTOR translation by directly interacting with the MTOR mRNA 5' UTR, activating downstream mTOR targets and impairing autophagic flux; reducing STAU1 in ALS mouse models normalizes mTOR activity and autophagy-related marker proteins. STAU1 overexpression/knockdown, mTOR 5' UTR binding assay, western blot for mTOR pathway components, mouse model intervention Autophagy Medium 36652469
2022 STAU1 indirectly binds the HBV core promoter (CP) via TARDBP (TDP-43) and recruits the SAGA transcriptional coactivator complex to upregulate CP activity; STAU1 also binds HBx protein and stabilizes it in a ubiquitin-independent manner. TurboID-based proximity labeling, co-immunoprecipitation, ChIP, reporter assays, siRNA knockdown iScience Medium 35663023
2021 STAU1 silencing in alveolar rhabdomyosarcoma (ARMS) cells reduces autophagy by destabilizing BECN1 and ATG16L1 mRNAs, and indirectly inhibits JNK signaling via increased DUSP8 expression; pharmacological JNK activation or DUSP8 silencing restores autophagy in STAU1-depleted ARMS cells. In contrast, in non-transformed skeletal muscle cells, STAU1 downregulation activates autophagy in an mTOR-dependent manner. siRNA knockdown, mRNA stability assay, western blot, JNK pathway pharmacological rescue, STAU1-transgenic mouse skeletal muscle analysis Cellular oncology Medium 33899158
2024 STAU1 stabilizes BACE1 mRNA by binding to its 3' UTR, extending BACE1 mRNA half-life; STAU1 also enhances GADD45B expression, activating P38 MAPK signaling to promote Tau phosphorylation at Ser396 and Thr181, thereby promoting both amyloidogenesis and tauopathy. STAU1 knockdown/overexpression, mRNA half-life assay, RIP for 3' UTR binding, transcriptome analysis, western blot for P38 MAPK pathway Experimental neurology Medium 38729552
2024 GIGYF2 upregulates STAU1, which then stabilizes PTEN mRNA by binding to its 3' UTR, leading to PI3K/AKT pathway inactivation and hepatic insulin resistance; STAU1 silencing prevents GIGYF2-induced PTEN upregulation and restores AKT signaling. RNA immunoprecipitation (RIP), siRNA knockdown, overexpression, western blot, in vivo high-fat diet mouse model Molecular medicine Medium 39138413
2023 STAU1 regulates alternative splicing of Pparγ2 pre-mRNA in 3T3-L1 adipocytes, specifically affecting the splicing of exon E1, as demonstrated by RIP and PAR-CLIP showing STAU1 binding to Pparγ2 pre-mRNA; knockdown/overexpression of STAU1 alters adipocyte differentiation and lipid metabolism gene splicing patterns. RNA immunoprecipitation (RIP), PAR-CLIP, sucrose density gradient centrifugation, RNA-seq for alternative splicing, siRNA knockdown Biochimica et biophysica acta. Molecular and cell biology of lipids Medium 36871938
2025 DDX50 monomers (formed upon glucose binding) bind STAU1 and redirect it from an RNA-decay-promoting complex with UPF1 to a DDX50-STAU1 ribonucleoprotein complex that stabilizes pro-differentiation mRNAs including JUN, OVOL1, CEBPB, PRDM1, and TINCR, reversing STAU1's canonical SMD role. Co-immunoprecipitation, RNA pulldown, CLIP-seq, mRNA stability assays, genetic knockdown, in vitro reconstitution of DDX50-STAU1 complex Cell reports Medium 39764852
2025 tRF-3019A competitively binds STAU1 protein, displacing BECN1 mRNA from STAU1, thereby enhancing BECN1 mRNA stability and expression, which promotes autophagy and malignant progression in colon cancer. RNA pulldown, RNA immunoprecipitation (RIP), western blot, GFP-LC3B autophagy assay, xenograft tumor model Cellular signalling Low 40268078
2025 STAU1 reduction inhibits p53-mediated apoptosis and DNA damage responses in multiple cell types (iPSC-derived neurons, mouse cortical neurons, SH-SY5Y cells, fibroblasts); in C9orf72-expanded patient fibroblasts and mouse ALS models with baseline STAU1 overabundance, STAU1 reduction prevents p53-driven pro-apoptotic signaling. RNAi knockdown, transcriptomic analysis, apoptosis assays (Nutlin-3 and etoposide treatment), p53 pathway western blot, patient-derived fibroblasts, C9orf72 mouse model Cell death & disease Medium 41145462
2026 STAU1 directly binds the 3' UTR of ITGB5 mRNA to stabilize it; ITGB5 upregulation increases FOXP3 phosphorylation at serine 418, which activates FOXP3 binding to the STAU1 promoter, creating a STAU1-ITGB5-FOXP3 positive feedback loop driving CRC metastasis. RIP, RNA stability assay, ChIP, siRNA knockdown, overexpression, in vitro and in vivo metastasis assays Cancer letters Low 41796846
2026 STAU1 binds the 3' UTR of Ucp1 mRNA and promotes its degradation via SMD; adipose-specific STAU1 deletion upregulates UCP1 protein and enhances thermogenesis in mice. The β3 adrenergic receptor/cAMP-PKA pathway modulates STAU1 activity, with cAMP-PKA inhibition downregulating STAU1. RIP for 3' UTR binding, adipose-specific Stau1 knockout mice, metabolic phenotyping, western blot, pharmacological pathway manipulation Metabolism: clinical and experimental Medium 42242623
2026 An Alu element in lnc-APUE base-pairs with the Alu element in the 3' UTR of CDH1 mRNA, triggering CDH1 mRNA decay via the STAU1-UPF1 (SMD) pathway; silencing STAU1 or UPF1 abrogates lnc-APUE-mediated CDH1 decay and tumor metastasis promotion. siRNA knockdown of STAU1/UPF1, Alu element deletion/mutation reporter assays, xenograft mouse model, RIP Advanced science Medium 41632098

Source papers

Stage 0 corpus · 41 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Nature 1018 21307942
2016 SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization. Nature communications 172 28004750
2013 STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown. Genes & development 111 23824540
2017 E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis. Cell death & disease 99 28569791
2012 Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells. The Journal of biological chemistry 60 22584570
2020 PABPC1-induced stabilization of BDNF-AS inhibits malignant progression of glioblastoma cells through STAU1-mediated decay. Cell death & disease 58 32015336
2020 lncRNA LINC00665 Stabilized by TAF15 Impeded the Malignant Biological Behaviors of Glioma Cells via STAU1-Mediated mRNA Degradation. Molecular therapy. Nucleic acids 57 32464546
2020 The PABPC5/HCG15/ZNF331 Feedback Loop Regulates Vasculogenic Mimicry of Glioma via STAU1-Mediated mRNA Decay. Molecular therapy oncolytics 29 32346611
2018 STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 29979632
2021 LncCCLM inhibits lymphatic metastasis of cervical cancer by promoting STAU1-mediated IGF-1 mRNA degradation. Cancer letters 25 34273467
2020 IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay. RNA biology 25 32713259
2008 Stau1 negatively regulates myogenic differentiation in C2C12 cells. Genes to cells : devoted to molecular & cellular mechanisms 20 18422603
2011 Stau1 regulates Dvl2 expression during myoblast differentiation. Biochemical and biophysical research communications 16 22166206
2024 Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration. The Journal of cell biology 15 38913026
2021 Stress Granule-Mediated Oxidized RNA Decay in P-Body: Hypothetical Role of ADAR1, Tudor-SN, and STAU1. Frontiers in molecular biosciences 14 34150849
2020 STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway. Oncology reports 14 33000283
1996 Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization. Genomics 14 8884277
2022 Identification of STAU1 as a regulator of HBV replication by TurboID-based proximity labeling. iScience 13 35663023
2021 Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non-transformed skeletal muscle cells. Cellular oncology (Dordrecht, Netherlands) 13 33899158
2024 RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade. Molecular medicine (Cambridge, Mass.) 12 39138413
2023 STAU1 promotes adipogenesis by regulating the alternative splicing of Pparγ2 mRNA. Biochimica et biophysica acta. Molecular and cell biology of lipids 9 36871938
2025 PLAGL2-STAU1-NCOA4 axis enhances gastric cancer peritoneal metastasis by resisting ferroptosis via ferritinophagy. Apoptosis : an international journal on programmed cell death 8 39987411
2024 STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells. Experimental neurology 7 38729552
2023 Effects of STAU1/staufen1 on autophagy in neurodegenerative diseases. Autophagy 7 36652469
2022 PART1 destabilized by NOVA2 regulates blood-brain barrier permeability in endothelial cells via STAU1-mediated mRNA degradation. Gene 7 34990795
2020 The dynamic transmission of positional information in stau- mutants during Drosophila embryogenesis. eLife 7 32511091
2000 Genomic organization of the human and mouse stau genes. DNA and cell biology 7 10882232
2025 Knockdown of STAU1 inhibits inflammation and autophagy in in vitro chronic obstructive pulmonary disease model by regulating AMPK-mTOR signaling pathway. Allergologia et immunopathologia 4 39786888
2024 STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer. Biology direct 4 39080743
2022 A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation. International journal of molecular sciences 4 36232890
2025 tRF-3019A/STAU1/BECN1 axis promotes autophagy and malignant progression of colon cancer. Cellular signalling 3 40268078
2022 Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells. International journal of molecular sciences 3 35806349
2025 DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs. Cell reports 2 39764852
2024 circular RNA circ-231 promotes protein biogenesis of TPI1 and PRDX6 through mediating the interaction of eIF4A3 with STAU1 to facilitate unwinding of secondary structure in 5' UTR, enhancing progression of human esophageal squamous cell carcinoma (ESCC). Journal of Cancer 2 38577609
2019 Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents. Molecular biology reports 1 30689188
2026 CCAT1 attenuates intermittent hypoxia associated endothelial cell pyroptosis through STAU1-mediated IRF1 mRNA degradation. Biochimica et biophysica acta. Molecular basis of disease 0 41520738
2026 TGFβ1 Activates Lnc-APUE to Promote Tumor Metastasis via the Alu Element-Driven STAU1-Mediated Decay of CDH1 mRNA. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 41632098
2026 STAU1-mediated stabilization of ITGB5 enhances FOXP3 transcriptional activity to form a self-reinforcing metastasis circuit in colorectal cancer. Cancer letters 0 41796846
2026 STAU1 fine-tunes adipose thermogenesis by regulating Ucp1 mRNA stability. Metabolism: clinical and experimental 0 42242623
2025 Targeting STAU1 prevents p53 apoptotic signaling in neurodegeneration. Cell death & disease 0 41145462
2008 Characterization of a novel transcript variant of human STAU1 gene. Acta biochimica Polonica 0 18806890

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