Affinage

RAB2A

Ras-related protein Rab-2A · UniProt P61019

Length
212 aa
Mass
23.5 kDa
Annotated
2026-06-10
79 papers in source corpus 43 papers cited in narrative 43 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB2A is a small GTPase that regulates membrane trafficking at multiple checkpoints along the secretory, endolysosomal, and autophagic pathways, with GTP hydrolysis required for vesicle movement between the ER and cis-Golgi (PMID:1429835). At pre-Golgi intermediates (VTCs/ERGIC) RAB2A nucleates an ordered effector cascade through its N-terminus: it recruits atypical PKC iota/lambda (PMID:11208158, PMID:14570876) and GAPDH (via distinct N-terminal binding sites, residues 1-19 and 20-50 respectively) (PMID:14570876, PMID:15485821), with Src acting upstream to tyrosine-phosphorylate both PKC iota/lambda and GAPDH; this assembly drives β-COP/coatomer recruitment and budding of COPI-coated retrograde vesicles from VTCs back to the ER (PMID:9642298, PMID:10359600, PMID:16452474, PMID:17488287). GAPDH's role here is structural rather than glycolytic (PMID:15485821), and the complex couples membranes to dynein and tyrosinated microtubules for transport (PMID:19106097). At the medial-Golgi, GTP-bound RAB2A forms an effector complex with GRASP55 and golgin-45 required for Golgi structure and secretory transport (PMID:11739401). RAB2A also controls dense-core and secretory granule maturation and cargo sorting via GTP-dependent effectors including ICA69, Noc2/RPH3AL, RUND-1 and CCCP-1 at the trans-Golgi (PMID:18187231, PMID:24698274, PMID:27927751, PMID:28755404). In the degradative arm, RAB2A drives autophagosome and late-endosome maturation by switching from a Golgi pool (bound to GM130/GOLGA2) to ULK1-complex and RUBCNL/STX17 associations that recruit the HOPS tethering complex—acting redundantly with RAB14—to promote autolysosome formation, a step antagonized by TBC1D4 (PMID:30957628, PMID:38964379, PMID:38953305). RAB2A activity is governed by an upstream GEF (GOP-1 in C. elegans) (PMID:28424218) and by AMPK-TBC1D1/TBC1D4 signaling, and RAB2A participates in hepatic lipid metabolism by enabling lipid-droplet-to-Golgi transfer for VLDL lipidation and secretion (PMID:35061665, PMID:39496977, PMID:41314545). RAB2A is also subverted by the Brucella effector RicA, which binds GDP-bound RAB2A to modulate vacuole biogenesis (PMID:21501366, PMID:24251537).

Mechanistic history

Synthesis pass · year-by-year structured walk · 33 steps
  1. 1992 High

    Established that RAB2 is a functional regulator of early secretory traffic by showing its GTPase cycle is required for ER-to-cis-Golgi vesicle transport.

    Evidence Trans-dominant GTP-binding/hydrolysis mutants and VSV-G transport readout in vivo

    PMID:1429835

    Open questions at the time
    • No effectors or molecular partners identified
    • Mechanism of GTP-dependent step undefined
  2. 1996 High

    Localized RAB2 function to a discrete N-terminal determinant controlling pre-Golgi intermediate assembly and cargo segregation, defining a functionally critical region distinct from the GTPase core.

    Evidence Truncation mutants and inhibitory N-terminal peptide in an in vitro VSV-G transport/VTC assay

    PMID:8910601

    Open questions at the time
    • N-terminal binding partners not yet identified
    • How the region acts mechanistically unknown
  3. 1998 High

    Connected RAB2 activity to COPI coat assembly, identifying the budding machinery RAB2 mobilizes at VTCs.

    Evidence Quantitative β-COP membrane-binding assay with recombinant RAB2 and N-terminal peptide, with pharmacological controls

    PMID:9642298

    Open questions at the time
    • Identity of the PKC-like kinase not yet established
    • Direct vs indirect coatomer recruitment unresolved
  4. 1999 High

    Defined RAB2 as controlling bidirectional membrane flow at VTCs, showing the active form stimulates retrograde COPI vesicle release while blocking anterograde delivery.

    Evidence In vitro reconstitution with purified Q65L mutant plus EM/fluorescence morphology

    PMID:10359600

    Open questions at the time
    • Effector chain still incomplete
    • Cargo selection mechanism undefined
  5. 2000 High

    Identified atypical PKC iota/lambda as a selectively recruited RAB2 effector whose kinase activity is required for retrograde budding, adding the first kinase to the cascade.

    Evidence Isoform-specific membrane-binding, kinase-dead and pseudosubstrate inhibitor experiments, vesicle budding assay

    PMID:11208158

    Open questions at the time
    • Relevant PKC substrates not yet identified
    • How recruitment is achieved structurally unknown
  6. 2001 High

    Revealed a separate medial-Golgi role through a GTP-dependent GRASP55/golgin-45 effector complex essential for Golgi architecture and transport.

    Evidence Yeast two-hybrid, Co-IP, depletion and Golgi morphology analysis

    PMID:11739401

    Open questions at the time
    • Relationship to the VTC cascade unresolved
    • Structural basis of effector recognition unknown
  7. 2003 High

    Mapped direct RAB2–PKC iota/lambda binding to N-terminal residues 1-19 and linked it to control of GAPDH phosphorylation, integrating the kinase into the N-terminal effector platform.

    Evidence Co-IP/pulldown, membrane-binding and in vitro kinase assays with truncation mutants

    PMID:14570876

    Open questions at the time
    • Functional consequence of GAPDH phosphorylation not yet defined
  8. 2004 High

    Identified GAPDH as a direct RAB2 effector (residues 20-50) acting in trafficking independently of its glycolytic activity, separating a moonlighting role from metabolism.

    Evidence Overlay binding, kinase assay, and transport rescue with a catalytically inactive GAPDH mutant in depleted cytosol

    PMID:15485821

    Open questions at the time
    • Structural role of GAPDH in budding unclear
    • Connection to coatomer recruitment mechanistically indirect
  9. 2006 High

    Ordered the cascade by placing Src upstream, showing Src phosphorylation of PKC iota/lambda is required for its assembly into the RAB2-Src-GAPDH complex and β-COP recruitment.

    Evidence Membrane-binding assays with Src inhibitor PP2 and vesicle budding readout

    PMID:16452474

    Open questions at the time
    • How Src itself is recruited/activated at VTCs not defined
  10. 2007 High

    Pinpointed GAPDH Tyr41 phosphorylation by Src as required for retrograde transport, refining the phospho-regulatory logic of the cascade.

    Evidence Kinase assay, membrane-binding, and transport reconstitution with Y41F mutant

    PMID:17488287

    Open questions at the time
    • In vivo relevance of Y41 phosphorylation not tested
  11. 2007 Medium

    Extended RAB2's secretory role to physiological cargo, showing RAB2-dependent retrograde transport controls cell-surface delivery and signaling of adrenergic GPCRs.

    Evidence siRNA, Q65L expression, cell-surface ELISA and ERK1/2/cAMP signaling assays

    PMID:17716866

    Open questions at the time
    • Direct vs indirect effect on GPCR trafficking not dissected
    • Single cell-type context
  12. 2008 High

    Linked the RAB2 effector platform to the cytoskeleton, showing GAPDH and PKC iota/lambda enable RAB2 membranes to bind tyrosinated microtubules and dynein.

    Evidence Microtubule co-sedimentation and membrane-binding assays for tubulin isoforms and motors

    PMID:19106097

    Open questions at the time
    • Direct motor adaptor for RAB2 membranes not identified
    • Directionality of transport not established
  13. 2008 Medium

    Identified ICA69 as a GTP-dependent RAB2 effector functioning in secretory granule cargo transport in insulin-secreting cells.

    Evidence GTP-dependent Co-IP, membrane recruitment and secretion assays in INS-1 cells

    PMID:18187231

    Open questions at the time
    • Molecular role of ICA69 in granule transport undefined
    • Single cell model
  14. 2008 High

    Through C. elegans genetics established a conserved RAB2 role in phagosome maturation, expanding RAB2 function beyond the secretory pathway into degradative trafficking.

    Evidence unc-108 loss-of-function, lysosome-phagosome fusion and acidification assays, live imaging

    PMID:18227280

    Open questions at the time
    • Effectors mediating phagosomal fusion not identified
  15. 2008 Medium

    Demonstrated a RAB2 role in postendocytic trafficking acting in parallel to MVB degradation, broadening its endosomal involvement.

    Evidence C. elegans genetics, GFP-cargo tracking, endocytic marker colocalization and epistasis

    PMID:18434599

    Open questions at the time
    • Molecular partners in endosomes undefined
    • Mechanism of parallel action unclear
  16. 2009 High

    Defined RAB2's role in dense-core vesicle maturation, showing it retains soluble and membrane cargo by preventing rerouting to early endosomes.

    Evidence Forward genetics, EM and quantitative cargo imaging with PI(3)P pathway epistasis in C. elegans

    PMID:19797080

    Open questions at the time
    • Effectors mediating cargo retention not yet identified in this study
  17. 2014 High

    Identified RUND-1 and CCCP-1 as RAB2 partners at the trans-Golgi and placed RAB2, its GAP TBC-8 and effector RIC-19 in a DCV maturation pathway.

    Evidence Forward genetic screen, interaction assays, colocalization and double-mutant analysis in C. elegans

    PMID:24698274

    Open questions at the time
    • Biochemical role of each effector in cargo sorting not fully resolved
  18. 2014 Medium

    Connected RAB2A inactivation to disease-relevant secretory failure, showing chronic high glucose drives GAPDH PARylation and dissociation, causing proinsulin aggregation at an aberrant ERGIC.

    Evidence siRNA, secretion assay, ubiquitin pulldown, PAR modification and RAB2A-GAPDH Co-IP in insulin-secreting cells

    PMID:25377857

    Open questions at the time
    • Direct causal chain from GAPDH loss to aggregation not fully dissected
  19. 2016 High

    Showed RAB2A drives oncogenic membrane trafficking in breast cancer, controlling MT1-MMP recycling via VPS39/HOPS and polarized E-cadherin delivery, linking RAB2A to invasion.

    Evidence siRNA screen, VPS39 Co-IP, trafficking and 3D invasion assays

    PMID:27255086

    Open questions at the time
    • How RAB2A coordinates two distinct trafficking steps unclear
  20. 2016 High

    Defined a ternary RAB2A-Noc2-RAB27a complex on immature secretory granules required for cargo processing, linking RAB2A to granule maturation through a coincidence-detection effector.

    Evidence GTP-dependent Co-IP, colocalization, granule maturation and insulin processing assays with binding-defective Noc2 mutants

    PMID:27927751

    Open questions at the time
    • Order of RAB2A/RAB27a action mechanistically inferred
    • Structural basis of dual-Rab binding unknown
  21. 2017 High

    Established RAB2 as a HOPS-binding driver of autophagosome and endosome maturation conserved from Drosophila to human cells, opening the autophagy arm of RAB2 biology.

    Evidence Drosophila genetics, HOPS Co-IP, GTP-locked mutant overexpression, lysosomal fusion and human siRNA assays

    PMID:28483915

    Open questions at the time
    • How RAB2 is recruited to autophagosomes not yet defined
    • Relationship to other autophagy Rabs unresolved
  22. 2017 High

    Identified GOP-1 as the GEF activating RAB2, defining the upstream regulator that loads RAB2 onto membranes for its maturation functions.

    Evidence Genetic screen, in vitro GEF activation/recruitment assay, nucleotide-state-specific pulldowns and epistasis in C. elegans

    PMID:28424218

    Open questions at the time
    • Mammalian RAB2A GEF not identified in this work
  23. 2017 Medium

    Extended the autophagy role to muscle remodeling and refined the CCCP-1 binding module, mapping a C-terminal domain sufficient for RAB2 binding and trans-Golgi targeting.

    Evidence Drosophila muscle genetics and HOPS Co-IP; CCCP-1 truncation/membrane-binding analysis

    PMID:28063257 PMID:28755404

    Open questions at the time
    • Lipid identity bound by CCCP-1 CC3 not determined
  24. 2018 Medium

    Showed RAB2 controls late-endosomal fusion processes including LAMP carrier delivery in a HOPS-independent recruitment manner, refining when HOPS is and is not required.

    Evidence Drosophila loss-of-function, colocalization, LAMP trafficking, autophagy flux and Arl8/HOPS epistasis

    PMID:29940804

    Open questions at the time
    • The non-HOPS recruitment factor for late endosomes unknown
  25. 2011 High

    Revealed RAB2 as a host target of bacterial pathogens, with Brucella RicA binding GDP-bound RAB2 to alter vacuole trafficking.

    Evidence Yeast two-hybrid, GST pulldown, T4SS translocation assay and ricA deletion analysis

    PMID:21501366

    Open questions at the time
    • Whether RicA acts as a GDI-like factor not directly tested here
  26. 2013 High

    Provided structural and quantitative binding insight into the RicA-RAB2 interaction, characterizing RicA's fold and its modest affinity for inactive RAB2.

    Evidence X-ray crystallography, X-ray fluorescence and ITC

    PMID:24251537

    Open questions at the time
    • No structure of RicA-RAB2 complex
    • Functional consequence of binding for RAB2 nucleotide state unresolved
  27. 2019 High

    Resolved how RAB2A switches between Golgi and autophagy roles via sequential interactions with GOLGA2, the ULK1 complex, and RUBCNL/STX17, providing the molecular logic of HOPS recruitment to autophagosomes.

    Evidence Sequential Co-IP, KO/KD, ULK1 kinase activity and autophagy flux assays in mammalian cells

    PMID:30957628

    Open questions at the time
    • Trigger driving the GOLGA2-to-ULK1 switch not defined
  28. 2024 High

    Established TBC1D4 as a dual-mode suppressor of RAB2A autophagic/endocytic function, binding RAB2A and RUBCNL through distinct PTB domains to block HOPS recruitment and fusion.

    Evidence Domain-mapping Co-IP, tissue-specific KO mice and autophagy/endocytic flux assays

    PMID:38964379

    Open questions at the time
    • Whether TBC1D4 also acts as a RAB2A GAP not directly shown
  29. 2024 High

    Demonstrated functional redundancy with RAB14 in HOPS recruitment to autophagosomes, explaining why single RAB2 loss gives only mild defects.

    Evidence Comprehensive RAB KO library, double-KO epistasis, VPS39/VPS41 Co-IP and LC3-II analysis in MDCK cells

    PMID:38953305

    Open questions at the time
    • Whether RAB2 and RAB14 act on the same or distinct autophagosome pools unclear
  30. 2022 Medium

    Implicated RAB2A in hepatic lipid metabolism downstream of AMPK-TBC1D1, where GTP-bound RAB2A stabilizes PPARγ to promote lipid accumulation.

    Evidence TBC1D1 knock-in and Rab2A-KD mouse models, GTP-RAB2A pulldown and PPARγ stability assays

    PMID:35061665

    Open questions at the time
    • Mechanism linking RAB2A to PPARγ stability undefined
  31. 2024 Medium

    Defined a lipid-handling role for Golgi RAB2A through interaction with the lipid-droplet protein HSD17B13, enabling LD-Golgi lipid transfer for VLDL secretion under AMPK control.

    Evidence Co-IP, LD-Golgi contact imaging, VLDL secretion assay and AMPK activation in hepatocytes

    PMID:39496977

    Open questions at the time
    • Direct lipid transfer mechanism not demonstrated
    • Specificity of HSD17B13 interaction not fully mapped
  32. 2025 Medium

    Placed RAB2A in a hepatic signaling axis where its loss impairs VLDL lipidation, causing APOB accumulation that activates CREBH and drives FGF21, connecting RAB2A trafficking to systemic metabolic signaling.

    Evidence Liver-specific Rab2A KD with adenoviral CREBH/APOB rescue and FGF21 measurement in mouse models

    PMID:41314545

    Open questions at the time
    • Direct trafficking step affected by RAB2A in VLDL lipidation not pinpointed
  33. 2021 Medium

    Extended RAB2 function to neuronal trafficking, showing it drives bidirectional axonal transport of DCVs and biogenesis of presynaptic precursor vesicles upstream of Arl8.

    Evidence Drosophila genetics, live axonal transport imaging, EM, electrophysiology and Arl8/BORC epistasis

    PMID:33822845 PMID:33852866

    Open questions at the time
    • Motor adaptors engaged by neuronal RAB2 not identified in these studies

Open questions

Synthesis pass · forward-looking unresolved questions
  • The identity of the mammalian RAB2A GEF and GAP and a unified structural model coupling the VTC effector cascade, Golgi GRASP55/golgin-45 complex, and HOPS-dependent autophagy functions remain undefined.
  • No mammalian RAB2A GEF identified
  • How a single GTPase coordinates secretory, granule-maturation and autophagic effectors mechanistically unresolved
  • No high-resolution structures of RAB2A effector complexes

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Partners
GAPDHGOLGA2GRASP55PRKCIRPH3ALSRCTBC1D4VPS39
Complex memberships
HOPS complex (RAB2A as recruiter/associated factor)

Evidence

Reading pass · 43 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 GTP-binding/hydrolysis mutants of Rab2 (equivalent to Ras 17N and 116I) act as trans-dominant inhibitors of vesicular stomatitis virus glycoprotein (VSV-G) transport between the ER and cis-Golgi complex in vivo, establishing that Rab2 GTP hydrolysis is required for vesicle traffic between early compartments of the secretory pathway. Vaccinia recombinant T7 RNA polymerase virus expression of site-directed Rab2 mutants; immunofluorescence analysis of VSV-G transport The Journal of cell biology High 1429835
1996 The N-terminus of Rab2 (first 14 amino acids) is required for its function in ER-to-Golgi transport; a peptide corresponding to residues 2–14 inhibits assembly of pre-Golgi intermediates (VTCs) and blocks anterograde/retrograde cargo segregation in an in vitro transport assay. Progressive truncation of dominant-negative Rab2 mutant; in vitro VSV-G transport assay with synthetic N-terminal peptide; biochemical and morphological analysis of VTCs The Journal of biological chemistry High 8910601
1998 Rab2 protein (and its N-terminal 13-mer peptide) enhances recruitment of β-COP (coatomer) to pre-Golgi intermediates in a manner requiring GTPγS, ADP-ribosylation factor, and protein kinase C-like activity, linking Rab2 activity to COPI coat recruitment at VTCs. Quantitative β-COP membrane-binding assay with recombinant Rab2 and synthetic peptide; immunofluorescence; subcellular fractionation The Journal of biological chemistry High 9642298
1999 Rab2 Q65L (GTPase-deficient, constitutively GTP-bound) arrests VSV-G transport from VTCs, stimulates release of retrograde vesicles enriched in β-COP and p53/gp58 but lacking anterograde cargo, and causes vesiculation of VTCs, indicating Rab2 regulates the low-temperature-sensitive step controlling membrane flow from VTCs to the Golgi and back to the ER. Purification of Rab2 Q65L; in vitro VSV-G transport reconstitution assay; quantitative β-COP membrane-binding assay; electron and fluorescence microscopy Molecular biology of the cell High 10359600
2000 Rab2 selectively recruits atypical PKC iota/lambda (but not PKCα or PKCγ) to VTC membranes; PKC iota/lambda kinase activity (but not its mere membrane association) is required for Rab2-mediated β-COP recruitment and retrograde vesicle budding from VTCs. Quantitative membrane-binding assay; Western blot for PKC isoforms; kinase-dead mutant and pseudosubstrate peptide inhibitor experiments; vesicle budding assay Traffic (Copenhagen, Denmark) High 11208158
2001 The GTP-bound form of Rab2 interacts specifically with golgin-45 and the medial-Golgi matrix protein GRASP55, forming an effector complex essential for secretory protein transport and normal Golgi structure; depletion of golgin-45 disrupts the Golgi apparatus and blocks secretory protein transport. Yeast two-hybrid; Co-IP; depletion experiments; Golgi morphology analysis The Journal of cell biology High 11739401
2003 Rab2 interacts directly with atypical PKC iota/lambda through Rab2 residues 1–19 (binding the PKC regulatory domain); Rab2 inhibits PKC iota/lambda-dependent phosphorylation of GAPDH; a Rab2 N-terminal truncation (Rab2NΔ19) fails to recruit PKC iota/lambda to membranes and does not inhibit GAPDH phosphorylation. In vivo and in vitro Co-IP/pulldown; quantitative membrane-binding assay; in vitro kinase assay with truncation mutants The Journal of biological chemistry High 14570876
2004 GAPDH interacts directly with Rab2 at residues 20–50; GAPDH is recruited to VTC membranes by Rab2 and phosphorylated by PKC iota/lambda; a catalytically inactive GAPDH mutant (C149G) still binds Rab2, is phosphorylated by PKC iota/lambda, and fully rescues VSV-G transport in GAPDH-depleted cytosol, demonstrating that GAPDH's role in early secretory trafficking is independent of its glycolytic activity. In vitro overlay binding assay; quantitative membrane-binding assay; in vitro kinase assay; in vitro VSV-G ER-to-Golgi transport reconstitution with GAPDH-depleted cytosol The Journal of biological chemistry High 15485821
2006 Rab2 promotes Src membrane recruitment to VTCs; Src tyrosine-phosphorylates PKC iota/lambda, which is required for PKC iota/lambda association with the Rab2-Src-GAPDH complex on VTCs; Src inhibition (PP2) abolishes PKC iota/lambda and β-COP recruitment without affecting Rab2, Src, or GAPDH binding, and dramatically reduces Rab2-mediated retrograde vesicle formation. Quantitative membrane-binding assay; Src kinase inhibitor (PP2); Western blot; vesicle budding assay The Journal of biological chemistry High 16452474
2007 GAPDH tyrosine-41 phosphorylation by Src is required for GAPDH function in Rab2-dependent retrograde transport: GAPDH Y41F is recruited to VTCs by Rab2 normally but blocks VSV-G transport by reducing PKC iota/lambda binding to GAPDH, thereby diminishing β-COP association with VTCs and vesicle formation. In vitro kinase assay; quantitative membrane-binding assay; in vitro VSV-G transport reconstitution; site-directed mutagenesis (Y41F) Traffic (Copenhagen, Denmark) High 17488287
2007 Rab2 (but not Rab6) controls retrograde Golgi-to-ER transport and thereby regulates anterograde cell-surface trafficking of α2B-adrenergic receptor and β2-adrenergic receptor; siRNA knockdown of Rab2 or expression of Rab2 Q65L reduces cell-surface expression and signaling (ERK1/2 activation, cAMP production) of these GPCRs. siRNA knockdown; dominant-active GTPase mutant expression; cell-surface ELISA; ERK1/2 and cAMP signaling assays Cellular signalling Medium 17716866
2008 Rab2 associates with microtubules only when both GAPDH and PKC iota/lambda are present; the Rab2 N-terminal fragment (residues 2–70) blocks MT binding; Rab2-treated membranes recruit predominantly tyrosinated α-tubulin and dynein (but not kinesin) in a PKC iota/lambda-dependent manner. Microtubule co-sedimentation assay; quantitative membrane-binding assay for tubulin isoforms and motor proteins; recombinant fragment inhibition The Journal of biological chemistry High 19106097
2008 ICA69 is a Rab2 effector that binds Rab2 in a GTP-dependent manner and is recruited to membranes by Rab2; overexpression of either Rab2 or ICA69 in insulinoma INS-1 cells impairs anterograde transport of secretory granule protein precursors and reduces stimulated insulin secretion. Co-IP (GTP-dependent); membrane recruitment assay; secretion assay; loss/gain-of-function in INS-1 cells European journal of cell biology Medium 18187231
2008 In C. elegans, UNC-108/Rab2 promotes phagosome maturation during apoptotic cell removal: it is required for efficient recruitment and fusion of lysosomes to phagosomes and for phagosomal lumen acidification; UNC-108 enriches on phagosomal surfaces and acts in engulfing cells. Loss-of-function genetic analysis; time-lapse microscopy; lysosome-phagosome fusion assay; pH indicator assay; fluorescence co-localization The Journal of cell biology High 18227280
2008 In C. elegans, UNC-108/Rab2 regulates postendocytic trafficking: unc-108 mutants accumulate GLR-1::GFP in tubulovesicular structures colocalizing with early/recycling endosome markers (Syntaxin-13, Rab8), and delay postendocytic trafficking of Texas Red-BSA in coelomocytes; unc-108 acts in parallel to the MVB degradation pathway. Genetic loss-of-function; GFP-tagged receptor trafficking; fluorescence co-localization; endocytic marker analysis; double-mutant epistasis Molecular biology of the cell Medium 18434599
2009 In C. elegans, Rab2 (UNC-108) acts in cell somas during dense-core vesicle (DCV) maturation to prevent loss of soluble and membrane cargo; in Rab2 null mutants, ~2/3 of DCV cargo (soluble and membrane, but not aggregated neuropeptides) is rerouted to early endosomes via a PI(3)P-dependent pathway. Forward genetic screen; electron microscopy of DCVs; quantitative fluorescence imaging of DCV cargo; PI(3)P pathway epistasis The Journal of cell biology High 19797080
2011 Brucella abortus effector RicA specifically interacts with the GDP-bound form of human Rab2 (confirmed by GST pulldown); RicA is translocated into macrophages via the VirB type IV secretion system; deletion of ricA reduces GTP-locked Rab2 recruitment to Brucella-containing vacuoles and alters intracellular trafficking kinetics. Yeast two-hybrid; GST pulldown; TEM-β-lactamase translocation assay; GTP-locked Rab2 co-localization on vacuoles; ricA deletion mutant analysis Cellular microbiology High 21501366
2013 X-ray crystal structure of Brucella abortus RicA (2.7 Å) reveals a γ-carbonic anhydrase fold with a Zn2+-binding active site; RicA binds human Rab2 (GDP-bound and nucleotide-free forms) with Kd ≈ 35–40 μM as measured by isothermal titration calorimetry. X-ray crystallography; X-ray fluorescence spectroscopy; isothermal titration calorimetry (ITC) Biochemistry High 24251537
2014 In C. elegans, two conserved Rab2-binding proteins RUND-1 (RUN domain) and CCCP-1 (coiled-coil) colocalize with RAB-2 at the trans-Golgi and are required for sorting soluble and transmembrane DCV cargo during maturation; RUND-1 also interacts with the Rab2 GAP TBC-8 and effector RIC-19, placing these proteins in a pathway controlling DCV maturation at the TGN. Forward genetic screen; protein interaction assays; fluorescence co-localization; double-mutant analysis; cargo sorting assays Neuron High 24698274
2014 RAB2A knockdown in insulin-secreting cells inhibits glucose-stimulated insulin secretion, enlarges the ERGIC, and causes accumulation of polyubiquitinated proinsulin aggregates at a unique large spheroidal ERGIC (LUb-ERGIC) with ERAD components; chronic high glucose inactivates Rab2A by promoting poly(ADP-ribosyl)ation of its effector GAPDH, causing GAPDH dissociation from Rab2A. siRNA knockdown; immunofluorescence; secretion assay; ubiquitin pulldown; PAR modification assay; Co-IP of Rab2A–GAPDH complex Scientific reports Medium 25377857
2015 Rab2A directly interacts with and prevents dephosphorylation/inactivation of Erk1/2 by the MKP3 phosphatase, resulting in sustained Erk1/2 activity, Zeb1 upregulation, and β-catenin nuclear translocation, thereby promoting breast cancer stem cell expansion. Co-IP; in vitro phosphatase protection assay; Erk1/2 activation readouts; β-catenin nuclear translocation; shRNA knockdown in primary BCSCs Cell reports Medium 25818297
2016 RAB2A controls two independent membrane trafficking steps in breast cancer cells: (1) post-endocytic recycling of MT1-MMP by interacting with VPS39 (HOPS complex component), enabling pericellular proteolysis; (2) polarized Golgi-to-plasma-membrane transport of E-cadherin, controlling junctional stability and invasiveness. siRNA functional screen; Co-IP with VPS39; MT1-MMP recycling assay; E-cadherin trafficking assay; 3D invasion assay; loss-of-function with specific phenotypic readouts EMBO reports High 27255086
2016 Rab2a and Rab27a simultaneously bind the effector Noc2 (RPH3AL) in a GTP-dependent manner (Rab2a binding requires prior Rab27a binding); the ternary Rab2a-Noc2-Rab27a complex localizes specifically to perinuclear immature secretory granules in pancreatic β-cells; Noc2 mutants defective in Rab2a binding impair cargo processing (proinsulin-to-insulin conversion) and glucose-stimulated insulin secretion. Co-IP (GTP-dependent); fluorescence co-localization; granule maturation assay; insulin processing assay; siRNA knockdown Journal of cell science High 27927751
2017 Drosophila Rab2 is required for autophagosome and endosome maturation: Rab2 binds to the HOPS tethering complex, its active GTP-locked form associates with autolysosomes, and expression of active Rab2 (but not active Rab7) promotes autolysosomal fusions; RAB2A knockdown in human breast cancer cells also impairs autophagosome clearance. Genetic loss-of-function in Drosophila; Co-IP with HOPS subunits; GTP-locked mutant overexpression; lysosomal fusion assays; siRNA in human cells The Journal of cell biology High 28483915
2017 Drosophila Rab2 loss-of-function in muscle leads to T-tubule remodeling defects; Rab2 localizes to autophagosomes and binds HOPS complex members, indicating a direct role in autophagosome tethering/fusion required for autophagic clearance during muscle remodeling. Genetic screen in Drosophila muscle; fluorescence localization; Co-IP with HOPS; T-tubule morphology analysis eLife Medium 28063257
2017 GOP-1 is a guanine nucleotide exchange factor (GEF) activator of C. elegans UNC-108/Rab2: GOP-1 transiently associates with phagosomes, interacts with GDP-bound and nucleotide-free UNC-108/Rab2, disrupts GDI-UNC-108 complexes, and promotes activation and membrane recruitment of UNC-108/Rab2 in vitro; loss of gop-1 abolishes phagosomal association of UNC-108 and phenocopies unc-108 mutants in phagosome maturation, endosome maturation, and DCV maturation. Genetic screen; in vitro activation/membrane recruitment assay; pulldown with different nucleotide-bound forms; epistasis with unc-108 The Journal of cell biology High 28424218
2017 The CCCP-1 C-terminal domain (CC3) is necessary and sufficient for localization to the trans-Golgi, binding to activated RAB-2, and function in DCV biogenesis; CC3 also binds membranes directly, suggesting a lipid-binding motif. Structure-function analysis with truncation/deletion mutants; Rab2 co-IP; membrane binding assay; DCV cargo sorting assay Traffic (Copenhagen, Denmark) Medium 28755404
2018 Drosophila Rab2 is recruited to late endosomal membranes and controls two fusion processes: delivery of LAMP-containing biosynthetic carriers to late endosomes, and fusion of autophagosomes with the endolysosomal pathway; Rab2 recruitment to late endosomal membranes does not require HOPS. Loss-of-function genetics; fluorescence co-localization; LAMP trafficking assay; autophagy flux assay; epistasis with Arl8/HOPS Autophagy Medium 29940804
2019 RAB2A connects the Golgi network to autophagy by sequential interactions: in unstressed cells RAB2A resides at the Golgi via interaction with GOLGA2/GM130; upon autophagy stimulation, RAB2A dissociates from GOLGA2 to interact with ULK1 complex and modulate ULK1 kinase activity for phagophore formation; RAB2A then switches to interact with RUBCNL/PACER and STX17 on autophagosomes to recruit the HOPS complex for autolysosome fusion. Co-IP; KO/KD in mammalian cells; autophagy flux assay; ULK1 kinase activity assay; fluorescence co-localization; Co-IP of sequential complexes Autophagy High 30957628
2020 Brucella T4SS effectors BspB and RicA show epistatic interaction mediated by host Rab2a: deletion of bspB causes rBCV biogenesis defects dependent on Rab2a, which are suppressed by co-deletion of ricA; double deletion of both effectors abolishes Rab2a requirement for rBCV biogenesis and Brucella replication, demonstrating that RicA modulation of Rab2a impairs replication, compensated by BspB-mediated remodeling of Golgi vesicular traffic. Bacterial genetic epistasis (deletion mutants); intracellular replication assays; rBCV biogenesis assays; Rab2a siRNA knockdown mBio Medium 32234817
2021 FAM71F1 (GARIN1A) binds both GTP-bound active RAB2A and RAB2B (but not inactive forms) via a RAB2-binding domain, as shown by immunoprecipitation and mass spectrometry; in FAM71F1-mutant mice, acrosome expansion is abnormal due to enhanced vesicle trafficking, suggesting FAM71F1 suppresses excessive RAB2A/B-mediated vesicle trafficking during acrosome formation. Immunoprecipitation/mass spectrometry; KO mice; acrosome morphology analysis; GTP/GDP-bound selectivity assay Development (Cambridge, England) Medium 34714330
2021 In Drosophila, Rab2 drives bidirectional axonal transport of dense-core vesicles, endosomes, and lysosomal organelles, most likely by controlling molecular motors; Arl8 is also required but specifically controls DCV exit from cell bodies into axons whereas Rab2 does not. Drosophila genetics; live imaging of axonal transport; DCV quantification in axons and cell bodies; epistasis with Arl8 and BORC Cell reports Medium 33852866
2021 In Drosophila, Rab2 is required for biogenesis of presynaptic precursor vesicles at the trans-Golgi: Rab2 mutants accumulate active zone and synaptic vesicle proteins at the trans-Golgi in cell bodies and deplete them from synaptic terminals, causing neurotransmission deficits; genetically, Rab2 acts upstream of Arl8 in precursor export from the Golgi. Drosophila loss-of-function genetics; fluorescence imaging; EM of presynaptic vesicles; electrophysiology; epistasis with Arl8 The Journal of cell biology Medium 33822845
2021 Tankyrase-1 (TNKS1) localizes to the Golgi via Golgin45; TNKS1 PARylates Golgin45, controlling its stability; Golgin45 protein level modulates Golgi glycosyltransferase trafficking in a Rab2-GTP-dependent manner (shown by FRAP), linking RAB2A GTP state to glycosyltransferase dynamics at the Golgi. FRAP; PARylation assay; glycomics; Co-IP; siRNA Communications biology Low 34876695
2022 Rab2A promotes NAFLD progression downstream of AMPK-TBC1D1 signaling: nutrition repletion suppresses AMPK-TBC1D1 phosphorylation, increasing GTP-bound Rab2A levels, which stabilizes PPARγ protein and promotes hepatic lipid accumulation; TBC1D1-S231A knock-in mice (mimicking suppressed phosphorylation) show elevated GTP-Rab2A and fatty liver. AMPK/TBC1D1 KI mice; Rab2A KD in DIO mice; GTP-Rab2A pulldown; PPARγ stability assay; hepatic lipid staining PLoS biology Medium 35061665
2022 RAB2A interacts with p53 and promotes phosphorylation of p53 at Ser33, activating the p53-dependent apoptotic signaling pathway in cardiomyocytes treated with doxorubicin. Co-IP; phospho-specific Western blot; Rab2A knockdown; apoptosis assays in vitro and in vivo Cell death discovery Low 35974003
2023 Rab2 overexpression stimulates LC3 lipidation on Rab2-containing cis/medial Golgi and ERGIC membranes through a non-canonical, nondegradative LC3 conjugation mechanism dependent on GAPDH; Rab2 overexpressing cells also show elevated Src activity. Transfection of Rab2B cDNA; morphological (fluorescence/EM) and biochemical (LC3-II Western blot) analysis; GAPDH dependence assay; Src activity measurement Experimental cell research Low 37201743
2024 TBC1D4 suppresses RAB2A-mediated autophagic and endocytic pathways: TBC1D4 binds RAB2A via its N-terminal PTB2 domain and impairs ULK1 complex activation; separately, TBC1D4 binds RUBCNL/PACER via its PTB1 domain to disrupt the RAB2A-RUBCNL-STX17 autophagosomal complex, blocking HOPS recruitment and autophagosome-lysosome fusion; hepatocyte- or adipocyte-specific TBC1D4 KO mice show elevated autophagic flux and tissue damage. Co-IP; domain-mapping with truncation mutants; KO mice (tissue-specific); autophagy flux assay; endocytic degradation assay Autophagy High 38964379
2024 RAB2 and RAB14 overlappingly regulate autophagosome maturation through recruitment of the HOPS complex (VPS39 and VPS41 subunits) to autophagosomes; RAB2 KO alone causes mild LC3-II accumulation, but RAB2/RAB14 double KO causes severe autophagy defect; both RAB2 and RAB14 localize to autophagosomes and interact with HOPS subunits. Comprehensive RAB KO library in MDCK cells; LC3-II Western blot; autophagosome localization; Co-IP with VPS39/VPS41; double KO epistasis Autophagy High 38953305
2024 Golgi-localized Rab2A selectively interacts with lipid droplet-resident protein HSD17B13, facilitating dynamic LD-Golgi organelle communication; this complex enables lipid transfer from LDs to the Golgi for VLDL2 lipidation and secretion; AMPK activation suppresses Rab2A activity and disrupts the Rab2A-HSD17B13 complex, impairing LD-Golgi interactions and VLDL secretion. Co-IP; live cell imaging of LD-Golgi contacts; VLDL secretion assay; Rab2A KD in hepatocytes; AMPK activation experiments The EMBO journal Medium 39496977
2025 Liver-specific Rab2A deficiency impairs VLDL lipidation and causes APOB accumulation; accumulated APOB drives cleavage and activation of CREBH, elevating hepatic FGF21 transcription and circulating FGF21; adenoviral knockdown of CREBH or APOB rescues the FGF21 elevation, defining a Rab2A-APOB-CREBH-FGF21 axis in hepatic metabolism. Liver-specific Rab2A KD; adenovirus-mediated CREBH/APOB KD rescue; APOB accumulation measurement; CREBH cleavage assay; FGF21 measurement; HFD mouse model The Journal of biological chemistry Medium 41314545
2025 RAB2A silencing causes 3-O-sulfotransferase-5 (3OST5) accumulation in the cis-Golgi and a delayed increase in heparan sulfate production; RAB1A silencing shifts 3OST5 to the trans-Golgi and increases HS levels acutely; RAB2A-silenced cells show compensatory upregulation of RAB1A protein, suggesting a dynamic interplay between RAB1A and RAB2A in maintaining vesicle trafficking balance for HS biosynthesis. siRNA knockdown; 3OST5 localization by immunofluorescence; HS quantification; Western blot for compensatory expression The FEBS journal Low 39804811
2025 In Drosophila, Rab2 on DCVs binds the dynein/kinesin-1 adaptor Sunday Driver/dJIP3/4 (Syd), which together with RUFY (a novel dynein adaptor that binds Arl8) forms a complex mediating retrograde DCV axonal transport; disruption of Rab2, Syd, RUFY, dynein, or BORC produces similar DCV axonal accumulation and reduced retrograde DCV flux; Rab2 also regulates DCV cargo sorting (VMAT, Synaptotagmin-α) independently of the Syd/RUFY/dynein transport machinery. Drosophila genetics; live imaging of DCV axonal transport; Co-IP (Rab2-Syd interaction); DCV flux quantification; epistasis analysis bioRxivpreprint Low bio_10.1101_2025.05.28.656585

Source papers

Stage 0 corpus · 79 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1992 GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex. The Journal of cell biology 455 1429835
2001 A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. The Journal of cell biology 193 11739401
2002 Rab2 GTPase regulates vesicle trafficking between the endoplasmic reticulum and the Golgi bodies and is important to pollen tube growth. The Plant cell 149 11971147
1996 Rab2 is essential for the maturation of pre-Golgi intermediates. The Journal of biological chemistry 120 8910601
2017 Rab2 promotes autophagic and endocytic lysosomal degradation. The Journal of cell biology 112 28483915
2011 Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2. Cellular microbiology 107 21501366
2019 RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. Autophagy 98 30957628
2004 Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity. The Journal of biological chemistry 89 15485821
2017 Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. eLife 85 28063257
2016 RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs. EMBO reports 81 27255086
2015 The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell reports 79 25818297
2009 Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2. The Journal of cell biology 74 19797080
2014 Two Rab2 interactors regulate dense-core vesicle maturation. Neuron 67 24698274
1999 A Rab2 mutant with impaired GTPase activity stimulates vesicle formation from pre-Golgi intermediates. Molecular biology of the cell 64 10359600
2008 The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans. The Journal of cell biology 63 18227280
2008 Rab2 utilizes glyceraldehyde-3-phosphate dehydrogenase and protein kinase C{iota} to associate with microtubules and to recruit dynein. The Journal of biological chemistry 57 19106097
2003 The N'-terminal domain of glyceraldehyde-3-phosphate dehydrogenase of the apicomplexan Plasmodium falciparum mediates GTPase Rab2-dependent recruitment to membranes. Biological chemistry 57 12974391
2014 Identification of COL3A1 and RAB2A as novel translocation partner genes of PLAG1 in lipoblastoma. Genes, chromosomes & cancer 53 24700772
2008 RAB2A: a major subacrosomal protein of bovine spermatozoa implicated in acrosomal biogenesis. Biology of reproduction 50 18401013
2007 Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases. Cellular signalling 49 17716866
2003 Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation. The Journal of biological chemistry 49 14570876
2008 UNC-108/Rab2 regulates postendocytic trafficking in Caenorhabditis elegans. Molecular biology of the cell 48 18434599
1998 Rab2 protein enhances coatomer recruitment to pre-Golgi intermediates. The Journal of biological chemistry 48 9642298
1990 The product of rab2, a small GTP binding protein, increases neuronal adhesion, and neurite growth in vitro. Neuron 48 2111712
2008 ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells. European journal of cell biology 43 18187231
2007 A GAPDH mutant defective in Src-dependent tyrosine phosphorylation impedes Rab2-mediated events. Traffic (Copenhagen, Denmark) 43 17488287
2018 Drosophila Rab2 controls endosome-lysosome fusion and LAMP delivery to late endosomes. Autophagy 42 29940804
2000 Rab2 requires PKC iota/lambda to recruit beta-COP for vesicle formation. Traffic (Copenhagen, Denmark) 42 11208158
1999 Characterization of a desiccation-responsive small GTP-binding protein (Rab2) from the desiccation-tolerant grass Sporobolus stapfianus. Plant molecular biology 41 10350094
2006 Src-dependent aprotein kinase C iota/lambda (aPKCiota/lambda) tyrosine phosphorylation is required for aPKCiota/lambda association with Rab2 and glyceraldehyde-3-phosphate dehydrogenase on pre-golgi intermediates. The Journal of biological chemistry 35 16452474
2021 Rab2 drives axonal transport of dense core vesicles and lysosomal organelles. Cell reports 32 33852866
2021 FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice. Development (Cambridge, England) 30 34714330
2020 Epistatic Interplay between Type IV Secretion Effectors Engages the Small GTPase Rab2 in the Brucella Intracellular Cycle. mBio 30 32234817
1992 Identification of rab2 as a tubulovesicle-membrane-associated protein in rabbit gastric parietal cells. The Biochemical journal 30 1323270
2021 Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi. The Journal of cell biology 28 33822845
2016 S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway. Cancer gene therapy 26 27767088
2014 Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells. Scientific reports 26 25377857
2016 Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2. Journal of cell science 24 27927751
2017 CSFV proliferation is associated with GBF1 and Rab2. Journal of biosciences 23 28229964
2022 Rab2A regulates the progression of nonalcoholic fatty liver disease downstream of AMPK-TBC1D1 axis by stabilizing PPARγ. PLoS biology 22 35061665
1996 Ethanol-induced retention of nascent proteins in rat hepatocytes is accompanied by altered distribution of the small GTP-binding protein rab2. The Journal of clinical investigation 22 8903335
2013 Molecular structure of the Brucella abortus metalloprotein RicA, a Rab2-binding virulence effector. Biochemistry 20 24251537
2015 Identification of RAB2A and PRDX1 as the potential biomarkers for oral squamous cell carcinoma using mass spectrometry-based comparative proteomic approach. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 18 26159854
2017 GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans. The Journal of cell biology 17 28424218
2024 Comprehensive knockout analysis of the RAB family small GTPases reveals an overlapping role of RAB2 and RAB14 in autophagosome maturation. Autophagy 16 38953305
2021 Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner. Communications biology 15 34876695
2021 LncRNA SOX2-OT regulates miR-192-5p/RAB2A axis and ERK pathway to promote glioblastoma cell growth. Cell cycle (Georgetown, Tex.) 14 34470582
2022 Long noncoding RNA NONMMUT015745 inhibits doxorubicin-mediated cardiomyocyte apoptosis by regulating Rab2A-p53 axis. Cell death discovery 13 35974003
2017 Harnessing membrane trafficking to promote cancer spreading and invasion: The case of RAB2A. Small GTPases 13 28060560
2017 The dense-core vesicle maturation protein CCCP-1 binds RAB-2 and membranes through its C-terminal domain. Traffic (Copenhagen, Denmark) 13 28755404
2016 Dictyostelium discoideum RabS and Rab2 colocalize with the Golgi and contractile vacuole system and regulate osmoregulation. Journal of biosciences 13 27240981
1992 Overexpression of the ras-related rab2 gene product in peripheral blood mononuclear cells from patients with hematological and solid neoplasms. Cancer research 13 1591721
2017 Regulation of neuromuscular junction organization by Rab2 and its effector ICA69 in Drosophila. Development (Cambridge, England) 12 28455372
2016 Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance. Journal of neurochemistry 12 26896628
2020 miR-376c-3p modulates the properties of breast cancer stem cells by targeting RAB2A. Experimental and therapeutic medicine 11 32963598
2024 Systematic characterization of all Toxoplasma gondii TBC domain-containing proteins identifies an essential regulator of Rab2 in the secretory pathway. PLoS biology 10 38713739
2024 Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. PLoS genetics 9 38935810
2005 Purification and functional interactions of GRASP55 with Rab2. Methods in enzymology 8 16473605
2024 Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes. The EMBO journal 7 39496977
2015 RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory. Human brain mapping 7 26249043
2012 Structural analysis of Brucella abortus RicA substitutions that do not impair interaction with human Rab2 GTPase. BMC biochemistry 7 22892012
2023 Rab2 and Rab6 are Implicated in Acrosome Formation during Spermatogenesis in Eriocheir sinensis: Based on Sperm Proteome. Frontiers in bioscience (Landmark edition) 6 37664930
2024 TBC1D4 antagonizes RAB2A-mediated autophagic and endocytic pathways. Autophagy 5 38964379
2020 MiR-381-3p/RAB2A axis activates cell proliferation and inhibits cell apoptosis in bladder cancer. Cellular and molecular biology (Noisy-le-Grand, France) 5 33040796
2024 ARL8B promotes hepatocellular carcinoma progression and inhibits antitumor activity of lenvatinib via MAPK/ERK signaling by interacting with RAB2A. Cellular signalling 4 39413890
2023 Rab2 stimulates LC3 lipidation on secretory membranes by noncanonical autophagy. Experimental cell research 4 37201743
2023 Integration of risk variants from GWAS with SARS-CoV-2 RNA interactome prioritizes FUBP1 and RAB2A as risk genes for COVID-19. Scientific reports 4 37932299
1993 A CD2+ subset of non-malignant peripheral blood lymphocytes from patients with Sézary syndromes overexpress the low-molecular-weight GTP-binding protein Rab2. Leukemia 4 8096558
1993 A possible role for the Ras-related Rab2 protein in the immunological events associated with hematological malignancies. Nouvelle revue francaise d'hematologie 4 8511040
2023 Toxoplasma gondii encodes an array of TBC-domain containing proteins including an essential regulator that targets Rab2 in the secretory pathway. bioRxiv : the preprint server for biology 3 37398139
2014 Vesicular Trafficking Defects, Developmental Abnormalities, and Alterations in the Cellular Death Process Occur in Cell Lines that Over-Express Dictyostelium GTPase, Rab2, and Rab2 Mutants. Biology 3 25157910
2005 Rab2 purification and interaction with protein kinase C iota/lambda and glyceraldehyde-3-phosphate dehydrogenase. Methods in enzymology 3 16473604
2024 Biophysical Evidence for the Amyloid Formation of a Recombinant Rab2 Isoform of Leishmania donovani. Protein and peptide letters 2 38661034
1992 Detection and characterization of mRNA and proteins encoded by human rab2 low molecular weight GTP-binding protein gene. Biochemistry international 2 1445391
2025 Functional characterization and phenotyping of RAB2A and Lactadherin/MFGE8 as boar sperm zona pellucida binding proteins. Frontiers in cell and developmental biology 1 41113455
2024 Identifying Rab2 Protein as a Key Interactor of Centrin1 Essential for Leishmania donovani Growth. ACS infectious diseases 1 39110117
2024 Metastatic Leiomyoma With Malignant Transformation Harboring RAB2A-PLAG1 Fusion: A Case Report and Review With Molecular Analysis. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1 39230504
2025 Involvement of GTPases and vesicle adapter proteins in Heparan sulfate biosynthesis: role of Rab1A, Rab2A and GOLPH3. The FEBS journal 0 39804811
2025 Rab2A modulates liver fibroblast growth factor 21 (FGF21) expression and systemic metabolism via apolipoprotein B-CREBH signaling. The Journal of biological chemistry 0 41314545

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