- Length
- 536 aa
- Mass
- 59.8 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
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Mechanism profile
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Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2005 | A human protein-protein interaction network: a resource for annotating the proteome. | Cell | 1704 | 16169070 |
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 1994 | Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. | Nature | 1477 | 7997267 |
| 1999 | Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. | Science (New York, N.Y.) | 1258 | 9924018 |
| 1997 | Three-dimensional structure of the tyrosine kinase c-Src. | Nature | 1248 | 9024657 |
| 2009 | An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. | Cell | 1202 | 19878981 |
| 2015 | The BioPlex Network: A Systematic Exploration of the Human Interactome. | Cell | 1118 | 26186194 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 2001 | Nerve growth factor signaling, neuroprotection, and neural repair. | Annual review of neuroscience | 1029 | 11520933 |
| 2011 | Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. | Nature | 920 | 22056988 |
| 2002 | Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. | Journal of immunology (Baltimore, Md. : 1950) | 900 | 12471095 |
| 1996 | A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. | Nature | 877 | 8849729 |
| 1995 | Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. | Molecular and cellular biology | 874 | 7529876 |
| 2003 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | Nature genetics | 754 | 14702039 |
| 1999 | Crystal structures of c-Src reveal features of its autoinhibitory mechanism. | Molecular cell | 739 | 10360179 |
| 1994 | Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. | Science (New York, N.Y.) | 728 | 8272872 |
| 2017 | Roles of tau protein in health and disease. | Acta neuropathologica | 716 | 28386764 |
| 2006 | Force sensing by mechanical extension of the Src family kinase substrate p130Cas. | Cell | 711 | 17129785 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 1996 | Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. | The Journal of biological chemistry | 684 | 8910575 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 1994 | A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. | The EMBO journal | 619 | 8070403 |
| 2008 | Large-scale proteomics and phosphoproteomics of urinary exosomes. | Journal of the American Society of Nephrology : JASN | 607 | 19056867 |
| 1996 | Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. | Cell | 607 | 8797825 |
| 1999 | c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. | The Journal of biological chemistry | 574 | 10075741 |
| 1998 | Stat3 activation by Src induces specific gene regulation and is required for cell transformation. | Molecular and cellular biology | 572 | 9566874 |
| 2005 | A quantitative protein interaction network for the ErbB receptors using protein microarrays. | Nature | 568 | 16273093 |
| 2000 | Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation. | The EMBO journal | 560 | 11032808 |
| 1990 | Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. | Science (New York, N.Y.) | 558 | 2173144 |
| 2015 | A gp130-Src-YAP module links inflammation to epithelial regeneration. | Nature | 539 | 25731159 |
| 1992 | Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. | Science (New York, N.Y.) | 516 | 1379745 |
| 1999 | TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. | Molecular cell | 502 | 10635328 |
| 1997 | RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. | Proceedings of the National Academy of Sciences of the United States of America | 493 | 9238002 |
| 2005 | Src kinase regulation by phosphorylation and dephosphorylation. | Biochemical and biophysical research communications | 481 | 15845350 |
| 1996 | The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. | Proceedings of the National Academy of Sciences of the United States of America | 381 | 8855229 |
| 2002 | SRC-1 and TIF2 control energy balance between white and brown adipose tissues. | Cell | 365 | 12507421 |
| 1979 | Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry. | Cell | 276 | 228858 |
| 2007 | Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. | The Journal of cell biology | 233 | 17353363 |
| 1995 | c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation. | The Journal of cell biology | 224 | 7542246 |
| 2003 | Regulation of cytochrome c oxidase activity by c-Src in osteoclasts. | The Journal of cell biology | 184 | 12615910 |
| 2000 | c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes. | The Journal of biological chemistry | 176 | 11035005 |
| 1984 | Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells. | Proceedings of the National Academy of Sciences of the United States of America | 153 | 6594680 |
| 2015 | miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer. | Cancer research | 132 | 26676753 |
| 2010 | Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome. | Molecular cancer research : MCR | 125 | 20353998 |
| 1995 | c-Src phosphorylates epidermal growth factor receptor on tyrosine 845. | Biochemical and biophysical research communications | 122 | 7488034 |
| 1996 | Catalytic specificity of phosphotyrosine kinases Blk, Lyn, c-Src and Syk as assessed by phage display. | Journal of molecular biology | 118 | 8709147 |
| 1996 | pp60(c-src) is required for cell locomotion regulated by the hyaluronanreceptor RHAMM. | Oncogene | 117 | 8950989 |
| 2012 | Development of a highly selective c-Src kinase inhibitor. | ACS chemical biology | 110 | 22594480 |
| 2008 | The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src. | Molecular cell | 107 | 18498747 |
| 1992 | Increased tyrosine kinase activity of c-Src during calcium-induced keratinocyte differentiation. | Proceedings of the National Academy of Sciences of the United States of America | 107 | 1381508 |
| 2008 | Structural basis for the recognition of c-Src by its inactivator Csk. | Cell | 106 | 18614016 |
| 1992 | Activation of c-Src in cells bearing v-Crk and its suppression by Csk. | Molecular and cellular biology | 106 | 1383688 |
| 1997 | Association of tyrosine-phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium. | The Journal of biological chemistry | 104 | 9020175 |
| 1998 | c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase. | The Journal of biological chemistry | 97 | 9565618 |
| 1995 | Functional interaction between c-Src and its mitotic target, Sam 68. | The Journal of biological chemistry | 97 | 7537265 |
| 2000 | JAB1 interacts with both the progesterone receptor and SRC-1. | The Journal of biological chemistry | 94 | 10722692 |
| 1990 | Identification of a novel neuronal C-SRC exon expressed in human brain. | Molecular and cellular biology | 93 | 1691439 |
| 1985 | Isolation of duplicated human c-src genes located on chromosomes 1 and 20. | Molecular and cellular biology | 88 | 2581127 |
| 2012 | Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components. | The Biochemical journal | 84 | 22823520 |
| 2003 | Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism. | The Journal of biological chemistry | 84 | 14551213 |
| 1997 | Role of c-Src tyrosine kinase in EGF-induced mitogenesis. | Frontiers in bioscience : a journal and virtual library | 84 | 9331427 |
| 2008 | Small molecule recognition of c-Src via the Imatinib-binding conformation. | Chemistry & biology | 82 | 18940662 |
| 2006 | The role of c-Src kinase in the regulation of osteoclast function. | Modern rheumatology | 78 | 16633924 |
| 2006 | Role of c-Src in human MCF7 breast cancer cell tumorigenesis. | The Journal of biological chemistry | 77 | 16728403 |
| 2007 | Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. | Cancer research | 76 | 17699771 |
| 2013 | Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism. | Scientific reports | 75 | 23416516 |
| 1987 | Expression of the c-src protooncogene in human skin tumors. | Cancer research | 74 | 2431764 |
| 2006 | Neurotensin stimulates mitogenesis of prostate cancer cells through a novel c-Src/Stat5b pathway. | Oncogene | 73 | 16862179 |
| 2003 | Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215. | FEBS letters | 72 | 12753909 |
| 2013 | Locking the active conformation of c-Src kinase through the phosphorylation of the activation loop. | Journal of molecular biology | 71 | 24103328 |
| 2005 | c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. | Cellular signalling | 71 | 15494217 |
| 2003 | Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma. | Digestive diseases and sciences | 70 | 14627343 |
| 1999 | Functional role of c-Src in gap junctions of the cardiomyopathic heart. | Circulation research | 69 | 10521240 |
| 2013 | c-Src modulates estrogen-induced stress and apoptosis in estrogen-deprived breast cancer cells. | Cancer research | 68 | 23704208 |
| 2004 | siRNA directed against c-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivity. | Journal of the American College of Surgeons | 63 | 15194078 |
| 2014 | c-Src drives intestinal regeneration and transformation. | The EMBO journal | 61 | 24788409 |
| 2019 | Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity. | European heart journal | 58 | 29077881 |
| 2016 | Transition path theory analysis of c-Src kinase activation. | Proceedings of the National Academy of Sciences of the United States of America | 58 | 27482115 |
| 2010 | c-Src differentially regulates the functions of microtentacles and invadopodia. | Oncogene | 58 | 20956943 |
| 2004 | Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction. | Proceedings of the National Academy of Sciences of the United States of America | 58 | 15070739 |
| 2008 | Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays. | Journal of proteome research | 57 | 18698806 |
| 2010 | The coactivator SRC-1 is an essential coordinator of hepatic glucose production. | Cell metabolism | 56 | 21109193 |
| 1995 | Autophosphorylation of purified c-Src at its primary negative regulation site. | The Journal of biological chemistry | 56 | 7592753 |
| 2020 | c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3. | Cell reports | 54 | 32209481 |
| 2002 | Role of c-SRC and ERK in acid-induced activation of NHE3. | Kidney international | 54 | 12081562 |
| 1997 | Intracellular acidosis activates c-Src. | The American journal of physiology | 54 | 9124524 |
| 1997 | c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells. | Biochemical and biophysical research communications | 54 | 9344858 |
| 2018 | Tescalcin/c-Src/IGF1Rβ-mediated STAT3 activation enhances cancer stemness and radioresistant properties through ALDH1. | Scientific reports | 52 | 30013043 |
| 2009 | c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential. | Molecular and cellular biology | 51 | 19704002 |
| 2008 | Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury. | The Biochemical journal | 51 | 18397177 |
| 2006 | A novel activating function of c-Src and Stat3 on HGF transcription in mammary carcinoma cells. | Oncogene | 47 | 16407846 |
| 2003 | Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation. | Hypertension (Dallas, Tex. : 1979) | 47 | 12719447 |
| 2000 | Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction. | American journal of physiology. Lung cellular and molecular physiology | 45 | 10956618 |
| 2007 | Calreticulin affects fibronectin-based cell-substratum adhesion via the regulation of c-Src activity. | The Journal of biological chemistry | 44 | 17389592 |
| 2000 | c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase. | Molecular and cellular biology | 44 | 10982853 |
| 2006 | c-Src control of chloride channel support for osteoclast HCl transport and bone resorption. | The Journal of biological chemistry | 43 | 16831863 |
| 2005 | Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis. | Oncogene | 43 | 15897873 |
| 2004 | Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation. | The Journal of biological chemistry | 43 | 14963038 |
| 1986 | pp60c-src encoded by the proto-oncogene c-src is a product of sensory neurons. | Journal of neuroscience research | 43 | 2427734 |
| 2014 | Endoplasmic reticulum stress induces epithelial-mesenchymal transition through autophagy via activation of c-Src kinase. | Nephron. Experimental nephrology | 41 | 24863135 |
| 2013 | Tissue transglutaminase regulates β-catenin signaling through a c-Src-dependent mechanism. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 41 | 23640056 |
| 2011 | Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. | Bioorganic & medicinal chemistry letters | 41 | 21856155 |
| 2005 | Novel insights into c-Src. | Current pharmaceutical design | 41 | 15853660 |
| 2020 | Targeted Degradation of Transcription Coactivator SRC-1 through the N-Degron Pathway. | Angewandte Chemie (International ed. in English) | 39 | 33026161 |
| 2013 | Development of a chimeric c-Src kinase and HDAC inhibitor. | ACS medicinal chemistry letters | 36 | 24015327 |
| 2006 | Compensatory ErbB3/c-Src signaling enhances carcinoma cell survival to ionizing radiation. | Breast cancer research and treatment | 36 | 16267617 |
| 2023 | Role of c-Src in Carcinogenesis and Drug Resistance. | Cancers | 35 | 38201459 |
| 2018 | c-Src activity is differentially required by cancer cell motility modes. | Oncogene | 34 | 29379163 |
| 2015 | Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis. | Frontiers in physiology | 34 | 26696895 |
| 2000 | Stimulation of c-Src by prolactin is independent of Jak2. | The Biochemical journal | 34 | 10600634 |
| 2013 | C-src enriched serum microvesicles are generated in malignant plasma cell dyscrasia. | PloS one | 33 | 23940647 |
| 2008 | Hexachlorobenzene triggers AhR translocation to the nucleus, c-Src activation and EGFR transactivation in rat liver. | Toxicology letters | 33 | 18295415 |
| 2014 | Global gene repression by the steroid receptor coactivator SRC-1 promotes oncogenesis. | Cancer research | 32 | 24648347 |
| 2002 | Endometrial nuclear receptor co-factors SRC-1 and N-CoR are increased in human endometrium during menstruation. | Molecular human reproduction | 32 | 12087079 |
| 2008 | N-acetyl-l-cysteine fosters inactivation and transfer to endolysosomes of c-Src. | Free radical biology & medicine | 31 | 18845245 |
| 1989 | Neuron-specific splicing of C-SRC RNA in human brain. | Journal of neuroscience research | 31 | 2681803 |
| 2019 | An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. | Nature communications | 29 | 31263101 |
| 2021 | Hydrophobic Tagging-Mediated Degradation of Transcription Coactivator SRC-1. | International journal of molecular sciences | 28 | 34203850 |
| 2002 | Arsenic carcinogenicity: relevance of c-Src activation. | Molecular and cellular biochemistry | 27 | 12162444 |
| 2021 | Paradoxical activation of c-Src as a drug-resistant mechanism. | Cell reports | 26 | 33761359 |
| 2007 | Regulation of c-Src by binding to the PDZ domain of AF-6. | The EMBO journal | 26 | 17491594 |
| 2021 | c-Src facilitates tumorigenesis by phosphorylating and activating G6PD. | Oncogene | 25 | 33686238 |
| 2009 | Increased levels of active c-Src distinguish invasive from in situ lobular lesions. | Breast cancer research : BCR | 25 | 19583841 |
| 2020 | EGFR/FAK and c-Src signalling pathways mediate the internalisation of Staphylococcus aureus by osteoblasts. | Cellular microbiology | 24 | 32584493 |
| 2019 | EGFR-c-Src-Mediated HDAC3 Phosphorylation Exacerbates Invasion of Breast Cancer Cells. | Cells | 24 | 31430896 |
| 2016 | Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization. | Oncotarget | 23 | 27472465 |
| 2011 | Ligand-dependent degradation of SRC-1 is pivotal for progesterone receptor transcriptional activity. | Molecular endocrinology (Baltimore, Md.) | 23 | 21273440 |
| 2020 | Glycation of fibronectin inhibits VEGF-induced angiogenesis by uncoupling VEGF receptor-2-c-Src crosstalk. | Journal of cellular and molecular medicine | 22 | 32613750 |
| 2009 | The PDZ protein MPP2 interacts with c-Src in epithelial cells. | Experimental cell research | 21 | 19665017 |
| 2000 | Regulation of collagenolytic protease secretion through c-Src in osteoclasts. | Biochemical and biophysical research communications | 21 | 10872813 |