Affinage

PRKCI

Protein kinase C iota type · UniProt P41743

Length
596 aa
Mass
68.3 kDa
Annotated
2026-06-10
68 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PRKCI (PKCι) is an atypical serine/threonine protein kinase that operates at the intersection of epithelial polarity control and oncogenic signaling (PMID:16319113, PMID:24525231). As the catalytic core of the PAR3–PAR6(PARD6B)–PKCι apical polarity complex, it is required tissue-autonomously for polarized epithelial organization, with kinase activity essential for myocardial coherence during heart morphogenesis (PMID:16319113) and for asymmetric self-renewing divisions of neural precursors (PMID:19449304); it supplies non-cell-autonomous polarity cues for ectodermal epithelialization and cavitation (PMID:27312576) and supports AEC2 stem-cell self-proliferation through the same complex (PMID:40001200). In human disease, PRKCI loss-of-function variants impair periderm differentiation upstream of IRF6, causing a palatogenesis defect (PMID:40902599), and a Prkci allele acts as a genetic modifier of CRB1-associated retinal dysplasia, integrating it into the apicobasal polarity network (PMID:35675330). As an oncogene, PRKCI is co-amplified with SOX2 and ECT2 at chromosome 3q26 and drives lung squamous carcinoma by phosphorylating SOX2 to activate HHAT-dependent cell-autonomous Hedgehog signaling (PMID:24525231, PMID:31968252), and it phosphorylates and activates GLI1 downstream of Hedgehog (PMID:35785194). Across colorectal cancer it phosphorylates substrates to stabilize oncogenic effectors and amplify signaling—Tgfbr1 (blocking proteasomal degradation to drive EMT and metastasis) (PMID:40382656), c-Myc at Ser21 (blocking ubiquitin-mediated degradation to promote proliferation) (PMID:41188443), and Jak2 at Ser633 (activating Jak2/Stat3/VEGFA angiogenic signaling) (PMID:40840329)—and it shapes an immunosuppressive microenvironment via TNFα and YAP1 (PMID:28698296). PRKCI also negatively regulates autophagy through the PIK3CA/AKT–mTOR axis, a function required for pancreatic acinar cell homeostasis (PMID:26792725, PMID:35159064). A distinct set of findings describe a nuclear, adenosine-polyphosphate-hydrolyzing PKCI/HINT1 protein that homodimerizes, binds RGSZ1 to modulate mu-opioid receptor signaling, and undergoes density-dependent nucleocytoplasmic shuttling (PMID:9770345, PMID:17126529); these belong to the HINT1 gene product and are noted here for completeness.

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1998 Medium

    Early characterization sought to define the basic biochemistry and localization of the PKCI protein, establishing a nuclear homodimer with enzymatic activity against adenosine polyphosphates.

    Evidence Yeast two-hybrid, in vitro enzymatic assay, and immunostaining in epithelial cell lines

    PMID:8812426 PMID:9770345

    Open questions at the time
    • These findings describe the HINT1/PKCI-1 hydrolase, not the PRKCI kinase, reflecting symbol ambiguity in the corpus
    • Conflicting nuclear vs cytoskeletal localization across cell types unresolved
  2. 2000 Medium

    Whether PKCI-1/HINT1 had protein partners controlling localization was addressed by identifying a Cdk7 interaction independent of kinase activity, with a functional genetic interaction in yeast.

    Evidence Yeast two-hybrid, co-IP, and HNT1/KIN28 genetic epistasis in S. cerevisiae

    PMID:10958787

    Open questions at the time
    • Pertains to HINT1, not the PRKCI kinase
    • Biochemical consequence of the interaction undefined
  3. 2005 High

    The in vivo developmental requirement for PKCι catalytic activity in epithelial polarity was established by showing tissue-autonomous, kinase-dependent rescue of myocardial coherence in zebrafish.

    Evidence Zebrafish heart and soul mutant with catalytic-dead complementation

    PMID:16319113

    Open questions at the time
    • Direct polarity substrates in myocardium not identified
    • Relationship to PAR complex assembly not biochemically resolved
  4. 2009 Medium

    The role of PKCι in cell-fate decisions was extended by showing its requirement for planar, asymmetric self-renewing divisions of spinal cord precursors.

    Evidence Time-lapse imaging and loss-of-function with cell-fate quantification in zebrafish

    PMID:19449304

    Open questions at the time
    • Molecular mechanism linking PKCι to division-plane orientation unknown
    • Substrates in precursor cells unidentified
  5. 2014 High

    A cell-autonomous oncogenic Hedgehog axis was uncovered: PKCι phosphorylates SOX2 to drive HHAT-dependent Hh ligand production in lung squamous carcinoma.

    Evidence Co-IP, ChIP, in vitro kinase assay, and functional rescue across cell and tumor models

    PMID:24525231

    Open questions at the time
    • SOX2 phosphosite mapping not detailed
    • Generality of the axis beyond LSCC untested
  6. 2016 Medium

    Two distinct PKCι functions were defined—negative regulation of autophagy via PIK3CA/AKT-mTOR, and provision of non-cell-autonomous polarity cues for epithelialization and cavitation.

    Evidence Gain/loss-of-function with autophagy flux readouts in U2OS cells; Prkci-null ES cell mixing and rescue experiments

    PMID:26792725 PMID:27312576

    Open questions at the time
    • Identity of the secreted/non-autonomous polarity cue undefined
    • Direct kinase link to mTOR pathway not established
  7. 2017 Medium

    PKCι's oncogenic role was shown to extend to the tumor microenvironment, promoting immune suppression via TNFα and acting through YAP1.

    Evidence Transgenic ovarian cancer mouse model with immune profiling and human tumor correlation

    PMID:28698296

    Open questions at the time
    • Direct kinase-substrate link to TNFα/YAP1 not shown
    • Single lab
  8. 2020 High

    The genetic basis of PRKCI oncogenicity in LSCC was placed in context: 3q26 co-amplification with SOX2 and ECT2 cooperatively transforms lung basal stem cells.

    Evidence Mouse genetic transformation model with epistasis and gene-signature analysis

    PMID:31968252

    Open questions at the time
    • Mechanistic separation of SOX2 vs ECT2 collaboration partially defined
    • Contribution of kinase activity per se not isolated
  9. 2022 High

    The autophagy function was validated in vivo and shown to constrain pancreatic tumorigenesis, while GLI1 was added as a direct activating substrate downstream of Hedgehog.

    Evidence Pancreas-specific Prkci knockout with autophagy markers and Kras epistasis; GLI1 phosphorylation/relocalization assays with xenografts

    PMID:35159064 PMID:35785194

    Open questions at the time
    • GLI1 phosphosite not mapped
    • Mechanism connecting PKCι to autophagic machinery still indirect
  10. 2024 Low

    Additional partners and signaling contexts were reported, including SQSTM1/p62 binding in osteosarcoma linked to Akt/mTOR.

    Evidence Co-IP and knockdown with Akt/mTOR readout in osteosarcoma cells

    PMID:39015499

    Open questions at the time
    • Single Co-IP without reciprocal validation; interaction not independently confirmed
    • Functional significance of p62 binding unclear
  11. 2025 High

    A burst of substrate-level studies defined how PKCι amplifies oncogenic signaling—stabilizing Tgfbr1, c-Myc(S21), and activating Jak2(S633)/Stat3/VEGFA—while a human-genetics study placed it upstream of IRF6 in palatogenesis and density-dependent shuttling was characterized.

    Evidence Co-IP/phosphosite mutagenesis/ubiquitination assays with in vivo CRC metastasis models; zebrafish patient-variant complementation with IRF6 rescue; live imaging and exportin-1 inhibition (preprint)

    PMID:35675330 PMID:40001200 PMID:40382656 PMID:40840329 PMID:40902599 PMID:41188443

    Open questions at the time
    • Whether the multiple CRC substrates are engaged simultaneously or context-dependently is unresolved
    • The density-dependent shuttling result is from a preprint describing HINT1, distinct from the PRKCI kinase

Open questions

Synthesis pass · forward-looking unresolved questions
  • A unified model reconciling PKCι's polarity-complex scaffolding function with its diverse oncogenic substrate repertoire, and clarifying which findings belong to PRKCI versus the co-symbolic HINT1 protein, remains to be established.
  • No structural model integrating PAR-complex binding with substrate selection
  • Substrate prioritization across tissues unknown
  • Corpus mixes PRKCI kinase and HINT1 hydrolase findings

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 5 GO:0016740 transferase activity 4
Localization
GO:0005886 plasma membrane 3 GO:0005634 nucleus 2 GO:0005856 cytoskeleton 2
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 4 R-HSA-9612973 Autophagy 2
Partners
JAK2PAR3PARD6BRGSZ1RIPK2SQSTM1TGFBR1
Complex memberships
PAR3-PAR6(PARD6B)-PKCι apical polarity complex

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2014 PKCι (PRKCI) phosphorylates SOX2 and recruits it to the promoter of Hedgehog acyltransferase (HHAT), the rate-limiting enzyme in Hh ligand production; PKCι-mediated SOX2 phosphorylation is required for HHAT promoter occupancy and HHAT expression, establishing a cell-autonomous Hh signaling axis in lung squamous cell carcinoma. Co-immunoprecipitation, chromatin immunoprecipitation, kinase assay, loss-of-function/overexpression in cell lines and primary tumors Cancer cell High 24525231
2020 PRKCI, SOX2, and ECT2 are co-overexpressed via chromosome 3q26 copy number gain; PRKCI and SOX2 collaborate to activate a transcriptional program enforcing a lineage-restricted LSCC phenotype, while PRKCI and ECT2 collaborate to promote oncogenic growth. Overexpression of all three in the context of Trp53 loss is sufficient to transform mouse lung basal stem cells into LSCC-like tumors. Mouse genetic transformation model, gene expression profiling, functional epistasis analysis Cell reports High 31968252
2017 PRKCI promotes an immune-suppressive tumor microenvironment in ovarian cancer by upregulating TNFα, which increases myeloid-derived suppressor cells and inhibits cytotoxic T-cell infiltration; YAP1 is identified as a downstream effector of PRKCI in tumor progression. Transgenic mouse model, functional assays, system-level analysis, gene expression correlation in human tumors Genes & development Medium 28698296
2005 Zebrafish heart and soul (Has)/PRKCi is required tissue-autonomously within the myocardium for polarized epithelial organization and coherence of myocardial cells during heart cone formation; this function depends on its catalytic activity. Zebrafish genetic mutant analysis, tissue-specific rescue experiments, catalytic-dead mutant complementation Development (Cambridge, England) High 16319113
2009 In zebrafish spinal cord, PrkCi function and planar cell divisions are necessary for asymmetric, self-renewing division of spinal cord precursors; loss of PrkCi causes oblique precursor divisions during late embryogenesis and excess oligodendrocyte production with concomitant loss of dividing cells. Time-lapse imaging of zebrafish, PrkCi loss-of-function analysis, cell fate quantification Developmental dynamics Medium 19449304
2016 PRKCI negatively regulates autophagy via the PIK3CA/AKT-MTOR signaling pathway; PRKCI overexpression impairs autophagic flux (decreased LC3B-II, reduced substrate degradation), while PRKCI knockdown or dominant-negative mutants (L485M, P560R) induce autophagy. Overexpression and siRNA knockdown in U2OS cells, LC3B-II immunoblot, autophagic substrate degradation assays, mutagenesis of PRKCI Biochemical and biophysical research communications Medium 26792725
2022 Pancreas-specific ablation of Prkci increases acinar cell DNA damage, apoptosis, and P62 aggregation with loss of autophagic vesicles, indicating that PKCι is required for pancreatic epithelial cell autophagy; Prkci loss promotes Kras-mediated pancreatic intraepithelial neoplasia formation but blocks progression to adenocarcinoma, consistent with disruption of autophagy. Pancreas-specific conditional knockout mice, histopathology, immunofluorescence, autophagy marker analysis Cancers High 35159064
2000 Hint/PKCI-1 physically interacts with Cdk7 (and the yeast ortholog Hnt1 with Kin28); overexpression of Cdk7 causes partial relocalization of Hint to the nucleus. This interaction is independent of cyclin H binding or Cdk7 kinase activity. Genetic combination of HNT1 disruption and a KIN28 temperature-sensitive allele in S. cerevisiae leads to elongated cell morphology and reduced colony formation. Yeast two-hybrid, co-immunoprecipitation, subcellular localization, yeast genetic epistasis The Journal of biological chemistry Medium 10958787
2006 PKCI-1 (HINT1) interacts with RGSZ1 as shown by co-immunoprecipitation and immunofluorescence; the RGSZ1-PKCI-1 complex modulates mu opioid receptor signaling—inhibition of cAMP by mu opioid receptor was significantly reduced by RGSZ1, an effect enhanced in combination with PKCI-1. The interaction requires the cysteine string region unique to the RZ subfamily of RGS proteins. Yeast two-hybrid, co-immunoprecipitation, immunofluorescence, cAMP functional assay Cellular signalling Medium 17126529
1998 Human PKCI (hPKCI) exists as a homodimer and interacts with a murine PKCI homologue in a yeast two-hybrid screen. The protein is expressed mainly in the nucleus of both normal and tumor-derived epithelial cell lines as determined by immunostaining. In vitro, hPKCI enzymatically hydrolyzes adenosine polyphosphates. Yeast two-hybrid, in vitro enzymatic assay, immunostaining/subcellular localization, Northern and Western blot Experimental cell research Medium 9770345
1996 Human PKCI-1 (hPKCI-1) localizes to cytoskeletal structures in the cytoplasm of human fibroblast cell lines as shown by indirect immunofluorescence, and is largely excluded from the nucleus. Indirect immunofluorescence, genomic FISH mapping Genomics Medium 8812426
2023 PRKCI physically interacts with RIPK2 (co-immunoprecipitation and immunofluorescence) and enhances phosphorylation of downstream NF-κB, JNK, and ERK signaling in pancreatic cancer cells. Co-immunoprecipitation, immunofluorescence, immunoblotting for phosphorylation Molecular medicine (Cambridge, Mass.) Medium 37016317
2022 PRKCI functions downstream of the Hedgehog/GLI1 pathway to phosphorylate and activate the transcription factor GLI1; PRKCI modulates radiosensitivity in cervical cancer by regulating GLI1 relocalization and phosphorylation. Western blotting, immunofluorescence, colony formation and apoptosis assays, xenograft model, PRKCI knockdown/overexpression Frontiers in oncology Medium 35785194
2016 Prkci is required to produce non-autonomous polarity cues necessary for forming a polarized ectodermal epithelium and cavitation in embryoid bodies; Prkci-null cells fail to properly segregate apical-basal proteins, form a coordinated ectodermal epithelium, or participate in normal cavitation. Mixing with wildtype cells rescues cavitation in Prkci-null cells, demonstrating the non-cell-autonomous nature of the polarity signal. Prkci-null ES cell analysis, mixing experiments, BMP4/EZRIN rescue, proliferation and apoptosis assays Developmental biology Medium 27312576
2025 PRKCI variants (including de novo p.Asn383Ser hotspot, p.Arg130His, and p.Leu385Phe) cause loss of function in a zebrafish periderm model; phosphomimetic IRF6 rescues aPKC inhibition, placing PRKCI upstream of IRF6 in the transcriptional regulatory network governing periderm differentiation and palatogenesis. Zebrafish functional complementation assay, patient variant analysis, phosphomimetic IRF6 rescue experiments American journal of human genetics High 40902599
2025 Prkci phosphorylates and stabilizes Tgfbr1 (TGF-β receptor 1), preventing its proteasomal degradation and amplifying downstream TGF-β signaling to promote epithelial-to-mesenchymal transition and colorectal cancer metastasis; Prkci knockout reduced liver and lung metastases in mouse models. Co-immunoprecipitation, phosphorylation assay, proteasomal degradation assay, in vivo xenograft/metastasis model with Prkci knockout Cell communication and signaling : CCS Medium 40382656
2025 Prkci phosphorylates c-Myc at serine 21, inhibiting its ubiquitin-mediated proteasomal degradation and stabilizing the protein; the pro-proliferative effect of Prkci in colorectal cancer is dependent on c-Myc S21 phosphorylation. Co-immunoprecipitation, phosphorylation site mutagenesis, ubiquitination assay, in vivo mouse tumor model with Prkci knockout NPJ precision oncology Medium 41188443
2025 Prkci activates the Jak2/Stat3 signaling pathway in colorectal cancer by phosphorylating Jak2 at the S633 site, leading to downstream Stat3 activation and increased VEGFA expression, thereby promoting tumor angiogenesis. In vitro endothelial cell proliferation/migration/tube formation assays, Prkci overexpression/knockout, in vivo xenograft model, immunoblotting for phosphorylation Neoplasia (New York, N.Y.) Medium 40840329
2024 PRKCI physically interacts with SQSTM1/p62 in osteosarcoma cells (co-immunoprecipitation); knockdown of PRKCI inhibits osteosarcoma cell proliferation by inactivating the Akt/mTOR signaling pathway. Co-immunoprecipitation, siRNA knockdown, CCK-8/colony formation/flow cytometry assays, immunoblotting for Akt/mTOR pathway Frontiers in oncology Low 39015499
2025 HINT1/PKCI-1 undergoes nucleocytoplasmic translocation regulated by exportin-1 in a cell-density-dependent manner: at low density it resides in the nucleus binding open chromatin, and as density increases it relocates to the cytoplasm where it inhibits PKC and remodels the actin cytoskeleton from stress fibers to a cortical network, facilitating monolayer maturation. Live cell imaging, subcellular fractionation, exportin-1 inhibition, HINT1 knockout, MARCKS phosphorylation assay bioRxivpreprint Medium bio_10.1101_2025.01.13.632869
2022 A mutation in Prkci (Tvrm323) acts as a genetic modifier of Crb1-associated retinal dysplasia in mice; epistasis analysis showed the increased dysplastic phenotype required homozygosity of the Crb1rd8 allele, placing Prkci in a pathway with the apicobasal polarity gene CRB1 in retinal tissue maintenance. Chemical mutagenesis screen, exome sequencing, genetic epistasis analysis, immunohistochemistry, electroretinography PLoS genetics Medium 35675330
2025 Reduced expression of the PAR3-PARD6B-PRKCI polarity complex in type II alveolar epithelial cells (AEC2s) arrests the cell cycle at G0-G1 phase, impairing AEC2 self-proliferation; co-immunoprecipitation and mass spectrometry confirmed PRKCI as a component of this complex. Co-immunoprecipitation, mass spectrometry, 3D spheroid formation, cell cycle analysis, in vitro smoke-injury model Stem cell research & therapy Medium 40001200
2001 Overexpression of PKCI increased radiation-induced apoptosis in normal LM cells and repressed c-fos transcription in a Ras-dependent manner; this effect was not observed in ATM-mutated AT cells, suggesting PKCI functions in the Ras-dependent signal transduction pathway regulating c-fos transcription. Transfection/overexpression, TUNEL apoptosis assay, CAT reporter assay for c-fos transcription, Western blot for Ras International journal of radiation oncology, biology, physics Low 11173133

Source papers

Stage 0 corpus · 68 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma. Cancer cell 250 24525231
2020 circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway. Molecular cancer 147 33234130
2002 Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. Genes & development 120 11877379
2000 Wpkci, encoding an altered form of PKCI, is conserved widely on the avian W chromosome and expressed in early female embryos: implication of its role in female sex determination. Molecular biology of the cell 113 11029061
2017 PRKCI promotes immune suppression in ovarian cancer. Genes & development 78 28698296
2005 Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis. Development (Cambridge, England) 72 16319113
2008 Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma. Genes, chromosomes & cancer 64 17990328
1998 Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family. Experimental cell research 62 9770345
2009 Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level. BMC neuroscience 54 19912621
2006 RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling. Cellular signalling 52 17126529
2000 Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins. The Journal of biological chemistry 52 10958787
2017 miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells. Journal of cell communication and signaling 49 28905214
2019 Circular RNA circ-PRKCI functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-3680-3p in esophageal squamous cell carcinoma. Journal of cellular biochemistry 45 30659640
2008 Distribution and expression of protein kinase C interactive protein (PKCI/HINT1) in mouse central nervous system (CNS). Neurochemical research 41 18270824
2020 Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma. Cell reports 32 31968252
2020 Circular RNA PRKCI silencing represses esophageal cancer progression and elevates cell radiosensitivity through regulating the miR-186-5p/PARP9 axis. Life sciences 32 32739469
2017 MiR-29c/PRKCI Regulates Axonal Growth of Dorsal Root Ganglia Neurons Under Hyperglycemia. Molecular neurobiology 31 28070856
2019 Circular RNA PRKCI promotes glioma cell progression by inhibiting microRNA-545. Cell death & disease 30 31409777
2020 Addiction to protein kinase Cɩ due to PRKCI gene amplification can be exploited for an aptamer-based targeted therapy in ovarian cancer. Signal transduction and targeted therapy 28 32820156
2021 circ-PRKCI targets miR-1294 and miR-186-5p by downregulating FOXK1 expression to suppress glycolysis in hepatocellular carcinoma. Molecular medicine reports 26 33880589
2019 Role and mechanism of circ-PRKCI in hepatocellular carcinoma. World journal of gastroenterology 24 31086464
1996 Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1). Genomics 24 8812426
2018 Down-regulation of circ-PRKCI inhibits cell migration and proliferation in Hirschsprung disease by suppressing the expression of miR-1324 target PLCB1. Cell cycle (Georgetown, Tex.) 23 29895226
2021 Silencing circRNA protein kinase C iota (circ-PRKCI) suppresses cell progression and glycolysis of human papillary thyroid cancer through circ-PRKCI/miR-335/E2F3 ceRNA axis. Endocrine journal 20 33716239
1992 Purification of PKC-I, an endogenous protein kinase C inhibitor, and types II and III protein kinase C isoenzymes from human neutrophils. The Biochemical journal 19 1599424
2022 Tumor Cell-Derived Exosomal circ-PRKCI Promotes Proliferation of Renal Cell Carcinoma via Regulating miR-545-3p/CCND1 Axis. Cancers 18 36612120
2014 miR-219 inhibits the growth and metastasis of TSCC cells by targeting PRKCI. International journal of clinical and experimental medicine 18 25356169
2001 Effect of protein kinase C inhibitor (PKCI) on radiation sensitivity and c-fos transcription. International journal of radiation oncology, biology, physics 18 11173133
2023 Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation. Molecular medicine (Cambridge, Mass.) 17 37016317
2016 PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling. Biochemical and biophysical research communications 17 26792725
2015 Association of polymorphisms in PRKCI gene and risk of prostate cancer in a sample of Iranian Population. Cellular and molecular biology (Noisy-le-Grand, France) 17 26475383
2017 Intratumoral Heterogeneity of Somatic Mutations for NRIP1, DOK1, ULK1, ULK2, DLGAP3, PARD3 and PRKCI in Colon Cancers. Pathology oncology research : POR 15 28844109
2017 Integrated genomic analysis of clear cell ovarian cancers identified PRKCI as a potential therapeutic target. Oncotarget 15 29228547
2022 Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice. Cancers 14 35159064
2020 Circular RNA PRKCI and microRNA-545 relate to sepsis risk, disease severity and 28-day mortality. Scandinavian journal of clinical and laboratory investigation 14 32985287
2019 Circular RNA circ-PRKCI promotes cell proliferation and invasion by binding to microRNA-545 in gastric cancer. European review for medical and pharmacological sciences 13 31773680
2006 PKCI-W forms a heterodimer with PKCI-Z and inhibits the biological activities of PKCI-Z in vitro, supporting the predicted role of PKCI-W in sex determination in birds. Journal of biochemistry 13 16428323
2022 Impact of deleterious missense PRKCI variants on structural and functional dynamics of protein. Scientific reports 12 35260606
2021 Circ-PRKCI Alleviates Lipopolysaccharide-induced Human Kidney 2 Cell Injury by Regulating miR-106b-5p/GAB1 Axis. Journal of cardiovascular pharmacology 12 34269703
2022 Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model. PLoS genetics 11 35675330
2009 Apical polarity protein PrkCi is necessary for maintenance of spinal cord precursors in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists 10 19449304
2022 PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer. Frontiers in oncology 9 35785194
2020 The interplay between PRKCI/PKCλ/ι, SQSTM1/p62, and autophagy orchestrates the oxidative metabolic response that drives liver cancer. Autophagy 9 32686580
2012 In vivo conditions to identify Prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish. PloS one 9 22768194
2014 Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population. Molecular carcinogenesis 6 24510606
2024 miR-630 as a therapeutic target in pancreatic cancer stem cells: modulation of the PRKCI-Hedgehog signaling axis. Biology direct 5 39529141
2020 Circular RNA circ-PRKCI promotes lung cancer progression by binding to microRNA-1324 to regulate MECP2 expression. European review for medical and pharmacological sciences 5 33155212
2024 Circular RNA PRKCI (hsa_circ_0067934): a potential target in the pathogenesis of human malignancies. Frontiers in oncology 4 38741779
2024 Downregulation of PRKCI inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway. Frontiers in oncology 4 39015499
2001 The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3. Cytogenetics and cell genetics 4 11978974
1999 HIT family genes: FHIT but not PKCI-1/HINT produces altered transcripts in colorectal cancer. British journal of cancer 4 10555761
2025 Has_circRNA_0122683 (circ-PRKCI) relieves ferroptosis of HPAEpiCs in sepsis-induced acute lung injury by sponging miR-382-5p. PeerJ 3 40386233
2023 Investigation of UTR Variants by Computational Approaches Reveal Their Functional Significance in PRKCI Gene Regulation. Genes 3 36833174
2021 Immunosurveillance, interferon, and autophagic networking in cancer: the PRKCI-ULK2 paradigm. Autophagy 3 34895031
2025 MK886 ameliorates Alzheimer's disease by activating the PRKCI/AKT signaling pathway. European journal of pharmacology 2 39922422
2025 The PAR6B-PRKCI-PAR3 complex influences alveolar regeneration in patients with the emphysema subtype of chronic obstructive pulmonary disease. Stem cell research & therapy 2 40001200
2025 Unravelling the role of PRKCI and key-cancer related genes in breast cancer development and metastasis. Discover oncology 2 40100546
2025 Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy. American journal of human genetics 2 40902599
2016 Prkci is required for a non-autonomous signal that coordinates cell polarity during cavitation. Developmental biology 2 27312576
2025 Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy. medRxiv : the preprint server for health sciences 1 39867391
2025 Prkci promotes colorectal cancer metastasis by phosphorylating and stabilizing Tgfbr1 to activate TGF-β signaling. Cell communication and signaling : CCS 1 40382656
2026 Circ-PRKCI attenuates acute lung injury secondary to sepsis by targeting the miR-106b-5p/GAB1 axis. European journal of medical research 0 41530882
2026 Correction: PRKCI mediates radiosensitivity via the Hedgehog/GLI1 pathway in cervical cancer. Frontiers in oncology 0 41608557
2026 Fibro-tubular tumors of the thyroid: an emerging thyroid neoplasm characterized by distinctive morphology and recurrent OCLN::PRKCI gene fusions spanning the adenoma-carcinoma spectrum. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 0 42128054
2025 Correction: Downregulation of PRKCI inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway. Frontiers in oncology 0 40692866
2025 Prkci activates Jak2/Stat3 signaling to promote tumor angiogenesis: Short Name: Prkci in tumor angiogenesis. Neoplasia (New York, N.Y.) 0 40840329
2025 Prkci acts a pro-proliferation factor in colorectal cancer. NPJ precision oncology 0 41188443
2022 Author Correction: Circular RNA circ-PRKCI promotes cell proliferation and invasion by binding to microRNA-545 in gastric cancer. European review for medical and pharmacological sciences 0 35113408

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