Affinage

PCM1

Pericentriolar material 1 protein · UniProt Q15154

Length
2024 aa
Mass
228.6 kDa
Annotated
2026-06-10
63 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PCM1 is the core scaffold protein of centriolar satellites, membrane-less granules that organize the microtubule- and dynactin-dependent delivery of cargo to the centrosome and govern ciliogenesis [PMID:12403812, PMID:bio_10.1101_2025.07.27.666075]. It self-assembles into granules through intrinsic multimerization mediated by N-terminal regions, and this assembly is regulated across the cell cycle, dispersing in mitosis and reforming in interphase [PMID:8120099, PMID:12571289, PMID:bio_10.1101_2025.07.27.666075]. Satellite integrity and client recruitment are controlled by phosphorylation: Plk4 phosphorylates the conserved S372 residue during G1 to drive PCM1 dimerization and satellite assembly (PMID:26755742), while a CDK1-primed interaction recruits Plk1 to the pericentriolar matrix to trigger HDAC6-dependent cilia disassembly before mitosis (PMID:23345402). As a scaffold, PCM1 recruits and stabilizes a broad set of clients to the centrosome—centrin, pericentrin, ninein, Nek2 and C-Nap1, CEP290, Hook3, and others—such that its loss disrupts radial microtubule organization and ciliogenesis (PMID:12403812, PMID:11171385, PMID:15659651, PMID:18772192, PMID:20152126). PCM1 also tethers the E3 ligase Mib1 to satellites to restrain ubiquitylation of the ciliogenic factor Talpid3 and permit recruitment of Rab8 ciliary vesicles (PMID:27146717), and PCM1 abundance is itself set by ubiquitin-dependent turnover, opposed by SNX17/USP9X and trichoplein and promoted by Mib1 (PMID:31671755, PMID:31666336, PMID:32337819). Through these activities PCM1 functions in neurodevelopment, linking centrosome asymmetry to polarized endosome dynamics (Rab5b→Rab11a) and Notch signaling in radial glia fate, and supporting neural progenitor migration via partners DISC1, BBS4, and Hook3 (PMID:18762586, PMID:20152126, PMID:41315244). In disease, the t(8;9) translocation fuses PCM1 coiled-coil domains to the JAK2 kinase domain, producing constitutive JAK2/STAT5 signaling in hematologic malignancy (PMID:15805263, PMID:23372669).

Mechanistic history

Synthesis pass · year-by-year structured walk · 22 steps
  1. 1994 Medium

    Established PCM1 as a large centrosomal protein whose association with the centrosome is cell-cycle-regulated, the first hint that it is a dynamic rather than constitutive structural component.

    Evidence Immunofluorescence across cell cycle stages with anti-recombinant PCM1 antibodies

    PMID:8120099

    Open questions at the time
    • Mechanism driving cycle-dependent association unknown
    • No molecular function assigned
  2. 2001 Medium

    Showed PCM1 physically associates with pericentrin-B and that centrosomal retention of both depends on intact microtubules, defining microtubule-dependent trafficking of a centrosomal complex.

    Evidence Reciprocal co-IP and microtubule nucleation/depolymerization assays on salt-stripped centrosomes

    PMID:11171385

    Open questions at the time
    • Did not establish satellite identity
    • No role in nucleation found
  3. 2002 High

    Placed PCM1 upstream in centrosome maturation by showing it is required for microtubule- and dynactin-dependent recruitment of centrin, pericentrin, and ninein.

    Evidence Three orthogonal loss-of-function approaches (antibody microinjection, dominant-negative, siRNA) with immunofluorescence

    PMID:12403812

    Open questions at the time
    • Direct versus indirect recruitment of each cargo not resolved
    • Did not address ciliogenesis
  4. 2003 Medium

    Defined the self-assembly mechanism, showing two N-terminal regions drive cell-cycle-regulated granule formation, establishing PCM1 as the satellite scaffold.

    Evidence Deletion-mutant overexpression and co-localization microscopy

    PMID:12571289

    Open questions at the time
    • Atomic basis of multimerization not defined
    • Regulators of assembly/disassembly unknown
  5. 2005 Medium

    Extended PCM1's scaffold role to recruitment of Nek2 kinase and C-Nap1, linking satellites to centrosomal kinase signaling.

    Evidence siRNA knockdown, FRAP, co-localization and co-sedimentation

    PMID:15659651

    Open questions at the time
    • Direct binding interface not mapped
    • Functional consequence for Nek2 activity unaddressed
  6. 2005 Medium

    Identified the oncogenic PCM1-JAK2 fusion from t(8;9), showing PCM1 coiled-coil domains drive constitutive JAK2 kinase activation in hematologic malignancy.

    Evidence RACE-PCR, RT-PCR, FISH and sequencing across patients

    PMID:15805263

    Open questions at the time
    • Downstream effector pathway not yet defined in this study
    • Mechanism of coiled-coil-driven dimerization not structurally resolved
  7. 2008 Medium

    Connected PCM1 to ciliogenesis by demonstrating a mutually dependent PCM1-CEP290 relationship required for ciliary Rab8 targeting.

    Evidence Co-IP and siRNA knockdown with ciliary phenotype

    PMID:18772192

    Open questions at the time
    • Hierarchy with other satellite clients incomplete
    • Single-lab Co-IP
  8. 2008 High

    Linked PCM1 to neurodevelopment, showing it forms a DISC1/BBS4 complex required for cargo targeting and cortical neuronal migration.

    Evidence Co-IP domain mapping plus in utero electroporation RNAi with genetic epistasis

    PMID:18762586

    Open questions at the time
    • Mechanism linking migration defect to specific cargo unresolved
  9. 2010 High

    Identified Hook3 as a direct PCM1 partner whose interaction governs interkinetic nuclear migration and neural progenitor pool maintenance.

    Evidence Co-IP, in utero electroporation RNAi, live imaging

    PMID:20152126

    Open questions at the time
    • Molecular link from satellites to nuclear migration machinery not detailed
  10. 2011 High

    Defined a HTT-HAP1-PCM1 retrograde trafficking pathway controlling ciliogenesis, with polyQ expansion causing aberrant PCM1 accumulation and abnormal cilia.

    Evidence Conditional knockout mice, Co-IP, live imaging, cilia measurement

    PMID:21985783

    Open questions at the time
    • How HAP1 hands PCM1 to dynein not resolved
    • Relationship to satellite assembly unaddressed
  11. 2013 High

    Established PCM1 as an upstream regulator of cilia disassembly, recruiting CDK1-primed Plk1 to activate HDAC6 before mitotic entry.

    Evidence shRNA knockdown, Co-IP, phosphorylation assays, immunofluorescence

    PMID:23345402

    Open questions at the time
    • Phosphosite on PCM1 mediating Plk1 binding not mapped here
  12. 2013 Medium

    Defined downstream signaling of the PCM1-JAK2 fusion, showing STAT5-dependent upregulation of SOCS2/SOCS3.

    Evidence Lentiviral knockdown, JAK2 inhibitor treatment, expression profiling

    PMID:23372669

    Open questions at the time
    • Causal role of SOCS genes in transformation not established
  13. 2016 High

    Identified Plk4 phosphorylation of PCM1 at S372 in G1 as the molecular trigger for PCM1 dimerization, satellite integrity, and ciliogenesis.

    Evidence In vitro kinase assay, S372A/S372D mutagenesis, functional rescue, Co-IP

    PMID:26755742

    Open questions at the time
    • How phosphorylation alters dimerization structurally unresolved
  14. 2016 High

    Revealed that PCM1 tethers the E3 ligase Mib1 to satellites to prevent ectopic Talpid3 ubiquitylation and permit ciliary vesicle recruitment.

    Evidence PCM1-null human cells, Co-IP, ubiquitylation assay, domain mapping

    PMID:27146717

    Open questions at the time
    • Full set of Mib1 substrates restrained by PCM1 not enumerated
  15. 2019 Medium

    Showed PCM1 abundance is set by ubiquitin-dependent turnover, with SNX17/USP9X deubiquitination opposing Mib1 specifically during starvation-induced ciliogenesis.

    Evidence Co-IP, siRNA knockdown, ubiquitination assay, ciliogenesis assay

    PMID:31671755

    Open questions at the time
    • Context-specificity to serum starvation not mechanistically explained
  16. 2019 Medium

    Demonstrated that Zika virus exploits MIB1-mediated PCM1 degradation to disperse satellites, connecting viral infection to satellite disassembly.

    Evidence Viral infection, MIB1 knockout cells, MG132, immunofluorescence and Western blot

    PMID:31666336

    Open questions at the time
    • How ZIKV raises MIB1 levels not defined
  17. 2020 Medium

    Identified trichoplein as a PCM1 stabilizer whose loss triggers proteasomal PCM1 degradation and impairs GABARAP-dependent autophagy.

    Evidence Co-IP, siRNA knockdown, autophagic flux assay, Tchp knockout mice

    PMID:32337819

    Open questions at the time
    • Direct link between satellite integrity and autophagic flux incomplete
  18. 2020 Medium

    Linked PCM1 in vivo to dopamine D2 receptor availability and behavior, supporting a neuropsychiatric role.

    Evidence Mouse knockout, immunoprecipitation, behavioral testing, RNAseq

    PMID:33214552

    Open questions at the time
    • Mechanism connecting ciliary defect to D2R level unresolved
  19. 2024 Medium

    Identified PCM1 as a redox-sensor whose oxidation/aggregation by necrosulfonamide disrupts ciliogenesis and drives autophagy accumulation.

    Evidence CRISPR deletion epistasis, ROS measurement, ciliogenesis and autophagy assays

    PMID:38600973

    Open questions at the time
    • Physiological relevance of redox sensing not established
    • Oxidized residues not mapped
  20. 2025 Medium

    Established PCM1 as a cargo-trafficking scaffold in spermiogenesis, governing centrosomal protein translocation via intra-manchette transport with male infertility upon loss.

    Evidence Pcm1 knockout mice, Co-IP, electron microscopy, ICSI

    PMID:40481240

    Open questions at the time
    • Specific cargo dependencies in manchette transport not fully mapped
  21. 2025 High

    Connected centrosome asymmetry to neural fate, showing PCM1 on Notch-ligand endosomes with Par-3 and dynein controls Rab5b→Rab11a transitions and progenitor self-renewal, conserved in human organoids.

    Evidence In vivo time-lapse imaging, expansion microscopy, Co-IP, loss-of-function, brain organoids

    PMID:41315244

    Open questions at the time
    • How asymmetric Cep83 association directs PCM1 to endosomes unresolved
  22. 2025 Medium

    Identified CCHCR1 as a determinant of PCM1 centrosomal localization within a PCM1/OFD1 ciliogenesis pathway that recruits P-body proteins.

    Evidence BioID/MS, Co-IP, GST pulldown, AB-FRET, CRISPR KO, immunofluorescence

    PMID:40883668

    Open questions at the time
    • Functional role of P-body protein recruitment to centrosome unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PCM1 multimerization is structurally organized into distinct satellite subdomains and how cytoskeletal and phosphorylation inputs are integrated into client recruitment hierarchy remain open.
  • No high-resolution structure of PCM1 multimers
  • Quantitative hierarchy of client recruitment incomplete
  • In vitro reconstitution evidence remains preprint

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 5 GO:0005198 structural molecule activity 2 GO:0140299 molecular sensor activity 1
Localization
GO:0005815 microtubule organizing center 3 GO:0005929 cilium 3 GO:0005856 cytoskeleton 2
Pathway
R-HSA-1852241 Organelle biogenesis and maintenance 4 R-HSA-9609507 Protein localization 4 R-HSA-1266738 Developmental Biology 3 R-HSA-1640170 Cell Cycle 3 R-HSA-1643685 Disease 2 R-HSA-9612973 Autophagy 2
Partners
BBS4CEP290DISC1HOOK3MIB1NEK2PCNTPLK1
Complex memberships
PCM1-DISC1-BBS4 complexPCM1-Par3-dynein endosomal complexcentriolar satellite

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 PCM-1 localizes to centriolar satellite granules and is required for microtubule- and dynactin-dependent recruitment of centrin, pericentrin, and ninein to the centrosome. Inhibition or depletion of PCM-1 (via antibody microinjection, dominant-negative overexpression, or siRNA) disrupts radial microtubule organization without affecting microtubule nucleation. Loss of centrin or ninein also disrupts microtubule organization, placing PCM-1 upstream of these proteins in centrosome maturation. Antibody microinjection, dominant-negative overexpression, siRNA knockdown, immunofluorescence microscopy The Journal of cell biology High 12403812
1994 PCM-1 is a 228-kDa centrosomal protein that dissociates from the centrosome late in G2 and remains dispersed during mitosis, then re-associates with centrosomes in G1 daughter cells, demonstrating cell-cycle-dependent centrosome association. Immunofluorescence microscopy with anti-recombinant PCM-1 antibodies across cell cycle stages The Journal of cell biology Medium 8120099
2003 PCM-1 self-aggregates through two distinct regions in its N-terminal domain to form granules (centriolar satellites), and this self-aggregation is regulated in a cell-cycle-dependent manner (disassembly during mitosis, reassembly in interphase). PCM-1 granules are distinct from pericentrin-containing granules but frequently associate with them. Overexpression of deletion mutants, immunofluorescence microscopy, co-localization studies Journal of cell science Medium 12571289
2001 PCM-1 and pericentrin-B coimmunoprecipitate, indicating they form a functional complex. The association of both proteins with salt-stripped centrosomes requires intact microtubules. Immunodepletion of neither PCM-1 nor pericentrin-B inhibited microtubule nucleation from salt-stripped centrosomes. Coimmunoprecipitation, immunodepletion, microtubule nucleation assay, microtubule depolymerization Journal of cell science Medium 11171385
2005 PCM-1-containing centriolar satellites are required for centrosomal recruitment of Nek2 kinase and its substrate C-Nap1. Nek2 exists in dynamic cytoplasmic particles that partially colocalize with PCM-1 satellites. Depletion of PCM-1 by siRNA interferes with centrosomal recruitment of Nek2. siRNA knockdown of PCM-1, FRAP, immunofluorescence co-localization, co-sedimentation Molecular biology of the cell Medium 15659651
2008 CEP290 binds PCM-1 and localizes to centriolar satellites in a PCM-1- and microtubule-dependent manner. Depletion of CEP290 disrupts PCM-1 distribution and protein complex formation. Both CEP290 and PCM-1 are required for ciliogenesis and ciliary targeting of Rab8. Coimmunoprecipitation, siRNA knockdown, immunofluorescence microscopy Human molecular genetics Medium 18772192
2008 PCM1 forms a complex with DISC1 and BBS4 through discrete binding domains in each protein. DISC1 and BBS4 are synergistically required for targeting PCM1 and cargo proteins (e.g., ninein) to the centrosome. Suppression of PCM1 in the developing cerebral cortex causes neuronal migration defects phenocopied by DISC1 or BBS4 suppression. Coimmunoprecipitation, immunofluorescence, RNAi in vivo (in utero electroporation) Archives of general psychiatry High 18762586
2010 Hook3 is recruited to pericentriolar satellites through direct interaction with PCM1. Disruption of the Hook3-PCM1 interaction in vivo impairs interkinetic nuclear migration of embryonic neural progenitors, leading to overproduction of neurons and premature depletion of the neural progenitor pool. Coimmunoprecipitation, in utero electroporation (RNAi), live imaging Neuron High 20152126
2011 Huntingtin (HTT) regulates retrograde trafficking of PCM1 to the centrosome through HAP1. Loss of Htt impairs PCM1 retrograde trafficking and reduces primary cilia formation. Pathogenic polyQ expansion causes centrosomal accumulation of PCM1 and abnormally long primary cilia. HTT-HAP1-PCM1 defines a pathway for centrosome protein trafficking and ciliogenesis. Conditional knockout mice, coimmunoprecipitation, immunofluorescence, live imaging, cilia measurement The Journal of clinical investigation High 21985783
2013 PCM1 acts upstream of Plk1 and recruits Plk1 to the pericentriolar matrix in a dynein-dynactin-dependent manner to promote primary cilia disassembly before mitotic entry. PCM1-Plk1 interaction is phosphorylation-dependent with CDK1 acting as the priming kinase. Plk1 then activates HDAC6 to deacetylate and resorb cilia. shRNA depletion of PCM1 disrupts pericentriolar accumulation of Plk1. shRNA knockdown, coimmunoprecipitation, phosphorylation assays, immunofluorescence microscopy Journal of cell science High 23345402
2016 PCM1 is essential for tethering the E3 ubiquitin ligase Mindbomb1 (Mib1) to centriolar satellites. In the absence of PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses ciliogenesis. Loss of PCM1 blocks recruitment of Rab8-associated ciliary vesicles to centrioles; this block can be reversed by inactivating Mib1. An amino-terminal domain of PCM1 restores ciliogenesis and satellite localization of certain proteins. Gene deletion (PCM1 null human cells), coimmunoprecipitation, ubiquitylation assay, immunofluorescence, domain mapping eLife High 27146717
2016 Plk4 phosphorylates PCM1 at the conserved S372 residue. This phosphorylation occurs during G1 phase and is required for PCM1 dimerization and interaction with other satellite components, as well as centriolar satellite integrity and ciliogenesis. Non-phosphorylatable S372A mutant recapitulates Plk4 depletion phenotypes; phosphomimetic mutant partially rescues dispersed satellites and ciliogenesis in PCM1-depleted cells. Kinase assay (Plk4 phosphorylation of PCM1), phosphomutant/phosphomimetic rescue experiments, coimmunoprecipitation, immunofluorescence EMBO reports High 26755742
2019 SNX17 recruits the deubiquitinating enzyme USP9X to antagonize MIB1-mediated ubiquitination and proteasomal degradation of PCM1 during serum-starvation-induced ciliogenesis. SNX17 deficiency leads to enhanced degradation of USP9X and PCM1 and disrupts ciliogenesis. This SNX17/USP9X pathway is dispensable for PCM1 homeostasis in serum-containing media. Co-immunoprecipitation, siRNA knockdown, ubiquitination assay, immunofluorescence, ciliogenesis assay Cells Medium 31671755
2019 Zika virus infection increases MIB1 (E3 ubiquitin ligase) levels, leading to MIB1-mediated ubiquitination and proteasomal degradation of PCM1, causing dispersion of PCM1-containing centriolar satellite granules. MIB1 knockout cells are resistant to ZIKV-induced PCM1 degradation and granule dispersion. Proteasome inhibitor MG132 prevents PCM1 loss. Viral infection, MIB1 knockout cells, proteasome inhibition (MG132), immunofluorescence, Western blot The Journal of biological chemistry Medium 31666336
2020 Trichoplein (TCHP) localizes to centriolar satellites, binds PCM1, and stabilizes it. Loss of TCHP leads to delocalization and proteasome-dependent degradation of PCM1, and further results in degradation of PCM1's binding partner GABARAP, impairing autophagic flux in endothelial cells. Coimmunoprecipitation, siRNA knockdown, immunofluorescence, autophagic flux assay, Tchp knockout mice EMBO reports Medium 32337819
2020 PCM1 ablation in mice leads to progressive ciliary integrity defects, reduced available dopamine D2 receptor (D2R) levels, and behavioral abnormalities. Immunoprecipitation shows an association between Pcm1 and D2Rs. Antipsychotic drugs fail to rescue adult behavioral defects in Pcm1-null mice. Mouse knockout, immunoprecipitation, immunofluorescence, behavioral testing, RNAseq Nature communications Medium 33214552
2013 PCM1-JAK2 fusion protein signals through STAT5 to upregulate SOCS2 and SOCS3. Lentiviral knockdown of PCM1-JAK2 inhibited these top upregulated genes. Treatment with a selective JAK2 inhibitor confirmed that JAK2 is the active signaling moiety. PCM1-JAK2 requires pSTAT5 for its downstream signaling. Lentiviral shRNA knockdown, JAK2 inhibitor treatment, gene expression profiling PloS one Medium 23372669
2024 Necrosulfonamide (NSA) causes oxidation and aggregation of PCM1 independently of MLKL, identifying PCM1 as a redox sensor protein. NSA-mediated ROS production disrupts ciliogenesis and leads to accumulation of autophagy markers; deletion of PCM1 partially alleviates NSA-induced autophagy accumulation. PCM1 deletion (CRISPR), ROS measurement, immunofluorescence, ciliogenesis assay, autophagy flux assay iScience Medium 38600973
2025 PCM1 binds centrosomal proteins and governs their translocation via intra-manchette transport during spermiogenesis. Pcm1 knockout mice exhibit disorganized manchette, head-tail coupling apparatus defects, defective flagellogenesis, and male infertility. Loss of PCM1 in sperm also causes severe retardation of embryo development that cannot be overcome by ICSI. Mouse knockout (Pcm1 KO), immunofluorescence, co-immunoprecipitation, electron microscopy, ICSI Communications biology Medium 40481240
2025 Pcm1 is asymmetrically associated with Cep83 (a mother centrosome marker) in radial glia progenitors (RGPs) and is detected on Notch ligand-containing endosomes in a complex with Par-3 and dynein. Loss of pcm1 disrupts endosome dynamics (impairing Rab5b-to-Rab11a transition) and reduces Par-3/dynein macromolecular complex assembly on recycling endosomes, increasing neuronal differentiation at the expense of RGP self-renewal. PARD3-PCM1-CEP83-RAB11 associations are conserved in human cortical brain organoids. In vivo time-lapse imaging, expansion microscopy, coimmunoprecipitation, loss-of-function (pcm1 KO/KD), clonal analysis, brain organoids Nature communications High 41315244
2025 Centriolar satellites (CS) assemble via a hierarchical pathway in which PCM1 scaffold formation (through intrinsic multimerization modulated by the cytoskeleton) precedes regulated client recruitment. PCM1 and its clients occupy distinct subdomains with different compositions and dynamics. Perturbing PCM1 multimerization impairs ciliary signaling. Cellular and in vitro CS biogenesis assays, high-resolution imaging, spatiotemporal quantification, PCM1 multimerization mutants bioRxivpreprint Medium bio_10.1101_2025.07.27.666075
2025 CCHCR1 interacts with PCM1 to determine its centrosomal localization. CCHCR1 also interacts with OFD1 (via its C-terminal coiled-coil domain) and recruits P-body proteins (EDC4) to the centrosome (via its N-terminal coiled-coil domain). Depletion of CCHCR1 impairs ciliogenesis, placing CCHCR1 in a PCM1/OFD1-dependent pathway for cilia development. BioID/mass spectrometry, coimmunoprecipitation, GST pulldown, AB-FRET, siRNA knockdown, CRISPR KO, immunofluorescence Cellular & molecular biology letters Medium 40883668
2005 The PCM1-JAK2 fusion gene created by t(8;9)(p22;p24) encodes a chimeric protein retaining coiled-coil domains from PCM1 and the entire tyrosine kinase domain of JAK2. This fusion constitutively activates JAK2 kinase activity and drives hematologic malignancy. Reciprocal JAK2-PCM1 mRNA was not detected. RACE-PCR, RT-PCR, FISH, sequencing of chimeric mRNA Cancer research Medium 15805263

Source papers

Stage 0 corpus · 63 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Assembly of centrosomal proteins and microtubule organization depends on PCM-1. The Journal of cell biology 412 12403812
2008 CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium. Human molecular genetics 244 18772192
2005 The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2. Cancer research 226 15805263
1994 PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution. The Journal of cell biology 143 8120099
2011 Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. The Journal of clinical investigation 131 21985783
2013 PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry. Journal of cell science 128 23345402
2008 Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Archives of general psychiatry 118 18762586
2016 Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis. eLife 103 27146717
2003 Non-membranous granular organelle consisting of PCM-1: subcellular distribution and cell-cycle-dependent assembly/disassembly. Journal of cell science 101 12571289
1996 Molecular and biochemical analysis of RET/PTC4, a novel oncogenic rearrangement between RET and ELE1 genes, in a post-Chernobyl papillary thyroid cancer. Oncogene 101 8806699
2005 The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. Oncogene 100 16091753
2010 Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron 98 20152126
2005 Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation. Molecular biology of the cell 98 15659651
2006 Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia. Archives of general psychiatry 72 16894060
2001 Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1. Journal of cell science 70 11171385
2014 Limited duration of complete remission on ruxolitinib in myeloid neoplasms with PCM1-JAK2 and BCR-JAK2 fusion genes. Annals of hematology 63 25260694
2007 Recruitment of P-TEFb (Cdk9-Pch1) to chromatin by the cap-methyl transferase Pcm1 in fission yeast. The EMBO journal 58 17332744
2021 Myeloid/Lymphoid Neoplasms Associated With Eosinophilia and Rearrangements of PDGFRA, PDGFRB, or FGFR1 or With PCM1-JAK2. American journal of clinical pathology 55 33367495
2020 Response to tyrosine kinase inhibitors in myeloid neoplasms associated with PCM1-JAK2, BCR-JAK2 and ETV6-ABL1 fusion genes. American journal of hematology 53 32279331
2016 A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation. EMBO reports 51 26755742
2016 PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide. Translational oncology 49 27661404
2006 Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo. Molecular and cellular biology 47 16428435
2013 t(8;9)(p22;p24)/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5. PloS one 41 23372669
2013 Hematologic malignancies with PCM1-JAK2 gene fusion share characteristics with myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1. Annals of hematology 31 23400675
2021 Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle. PLoS genetics 22 34752468
2019 SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis. Cells 21 31671755
2020 PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. Nature communications 20 33214552
2010 PCM1-JAK2-fusion: a potential treatment target in myelodysplastic-myeloproliferative and other hemato-lymphoid neoplasms. Expert opinion on therapeutic targets 20 21091042
2020 Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. EMBO reports 19 32337819
2019 Zika virus increases mind bomb 1 levels, causing degradation of pericentriolar material 1 (PCM1) and dispersion of PCM1-containing granules from the centrosome. The Journal of biological chemistry 18 31666336
2022 PCM1-JAK2 Fusion Tyrosine Kinase Gene-Related Neoplasia: A Systematic Review of the Clinical Literature. The oncologist 15 35472244
1999 Do damaged proteins accumulate in Caenorhabditis elegans L-isoaspartate methyltransferase (pcm-1) deletion mutants? Archives of biochemistry and biophysics 15 10190976
2011 No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. Schizophrenia research 13 21481569
1995 Characterization of the basic replicon of pCM1, a narrow-host-range plasmid from the moderate halophile Chromohalobacter marismortui. Journal of bacteriology 13 7768853
2011 H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4. The EMBO journal 12 22139357
2024 Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes. The FEBS journal 11 38825736
2023 Two activating phosphorylation sites of Pbs2 MAP2K in the yeast HOG pathway are differentially dephosphorylated by four PP2C phosphatases Ptc1-Ptc4. The Journal of biological chemistry 11 36870684
2022 PCM1 labeling reveals myonuclear and nuclear dynamics in skeletal muscle across species. American journal of physiology. Cell physiology 10 36409178
2019 Centrosome-derived microtubule radial array, PCM-1 protein, and primary cilia formation. Protoplasma 10 31079229
2013 A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM-1) protein binds β-amyloid (Aβ1-42 ) oligomers. Journal of neurochemistry 10 23432034
2023 Rare and potentially fatal - Cytogenetically cryptic TNIP1::PDGFRB and PCM1::FGFR1 fusion leading to myeloid/lymphoid neoplasms with eosinophilia in children. Cancer genetics 9 36657267
2010 PCM1 and schizophrenia: a replication study in the Northern Swedish population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 9 20468070
2007 Autophagy and insulin/TOR signaling in Caenorhabditis elegans pcm-1 protein repair mutants. Autophagy 9 17404495
2019 What went wrong with variant effect predictor performance for the PCM1 challenge. Human mutation 8 31268618
2022 Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1-JAK2 positive myeloid sarcoma and acute B-lymphoblastic leukemia. Clinical case reports 7 35028141
2021 LncRNA-ENST00000421645 promotes T cells to secrete IFN-γ by sponging PCM1 in neurosyphilis. Epigenomics 7 34382410
2012 Identification of protein kinase C inhibitory activity associated with a polypeptide isolated from a phage display system with homology to PCM-1, the pericentriolar material-1 protein. Biochemical and biophysical research communications 7 22732405
1998 Localization of autoepitopes on the PCM-1 autoantigen using scleroderma sera with autoantibodies against the centrosome. Molecular biology reports 6 9540072
2022 PCM1::JAK2 fusion associates with an atypical form of mycosis fungoides. Virchows Archiv : an international journal of pathology 5 35786767
2025 PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation. Communications biology 4 40481240
2021 Nanopore sequencing for the screening of myeloid and lymphoid neoplasms with eosinophilia and rearrangement of PDGFRα, PDGFRβ, FGFR1 or PCM1-JAK2. Biomarker research 4 34772467
2025 PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate. Nature communications 3 41315244
2019 RNA Sequencing Analysis for the Identification of a PCM1/PDGFRB Fusion Gene Responsive to Imatinib. Acta haematologica 3 31085913
2012 A huntingtin-HAP1-PCM1 pathway in ciliogenesis. Expert review of proteomics 3 22292820
2024 Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy. iScience 2 38600973
2024 PCM1 conveys centrosome asymmetry to polarized endosome dynamics in regulating daughter cell fate. bioRxiv : the preprint server for biology 1 38948739
2023 NKD1 targeting PCM1 regulates the therapeutic effects of homoharringtonine on colorectal cancer. Molecular biology reports 1 37338734
2022 Myeloid Neoplasm with PCM1-PDGFRB Transcript Responded to Low-Dose Imatinib: One Case Report with Literature Review. Acta haematologica 1 35340014
2026 A case report and a literature review of Myeloid/Lymphoid Neoplasm with Eosinophilia and PCM1::JAK2 rearrangement representing as B-cell acute lymphoblastic leukemia B-ALL. Annals of hematology 0 41530508
2025 A Case of Myeloproliferative Neoplasm with Eosinophilia Associated with PCM1-JAK2 Rearrangement. Case reports in oncology 0 39980500
2025 CCHCR1 links P-body proteins to the centrosome and is required for ciliogenesis through interacting with OFD1 and PCM1. Cellular & molecular biology letters 0 40883668
2024 A rare case of hypereosinophilic endomyocardial fibrosis due to PCM1-JAK2. The British journal of cardiology 0 41846857
2006 Expression of citrate permease gene of plasmid pCM1 isolated from Lactococcus lactis subsp. lactis biovar diacetylactis NIAI N-7 in Lactobacillus casei L-49-4. Applied microbiology and biotechnology 0 17139509

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