Affinage

PCM1

Pericentriolar material 1 protein · UniProt Q15154

Length
2024 aa
Mass
228.6 kDa
Annotated
2026-04-29
63 papers in source corpus 22 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PCM1 is the principal scaffold of centriolar satellites—cytoplasmic granules that traffic centrosomal and ciliary cargo along microtubules via dynein-dynactin to regulate centrosome composition, primary cilia assembly and disassembly, and polarized cell fate decisions. PCM1 self-multimerizes through N-terminal domains in a Plk4-phosphorylation-dependent manner to nucleate satellite granules that recruit and deliver centrin, pericentrin, ninein, Nek2, Plk1, CEP290, and other clients to the centrosome, with granule assembly dissolved during mitosis and restored in interphase (PMID:12403812, PMID:12571289, PMID:26755742). By sequestering the E3 ubiquitin ligase Mib1 at satellites, PCM1 prevents Mib1-mediated poly-ubiquitination and degradation of the ciliogenesis factor Talpid3, thereby licensing Rab8-positive vesicle recruitment and ciliogenesis; conversely, PCM1 loss releases Mib1 to destroy ciliary clients (PMID:27146717, PMID:31666336). Beyond cilia, PCM1 forms complexes with DISC1/BBS4 and Par-3/dynein to govern neuronal migration and neural progenitor self-renewal through centrosome-coupled endosome dynamics, and its coiled-coil domains are exploited by the t(8;9) PCM1–JAK2 translocation to drive constitutive JAK2-STAT5 signaling in hematologic malignancies (PMID:18762586, PMID:41315244, PMID:15805263).

Mechanistic history

Synthesis pass · year-by-year structured walk · 22 steps
  1. 1994 High

    Identifying PCM1 as a pericentriolar component with cell-cycle-regulated centrosome association established that the pericentriolar matrix is compositionally dynamic rather than static.

    Evidence Immunofluorescence with anti-recombinant PCM1 antibodies across synchronized cell cycle stages in cultured cells

    PMID:8120099

    Open questions at the time
    • No functional consequence of cell-cycle dissociation was tested
    • Mechanism of mitotic dispersal unknown
  2. 2001 Medium

    Demonstrating that PCM1 and pericentrin form a microtubule-dependent complex at the centrosome revealed that pericentriolar material assembly requires active transport rather than simple diffusion.

    Evidence Reciprocal co-immunoprecipitation plus salt-stripped centrosome reconstitution with microtubule disruption

    PMID:11171385

    Open questions at the time
    • Direct vs. indirect interaction not resolved
    • Single lab without independent replication
  3. 2002 High

    Multiple loss-of-function approaches showed that PCM1 is required for centrosomal delivery of centrin, pericentrin, and ninein via dynactin-dependent transport, establishing PCM1 as a cargo adaptor for centrosome assembly.

    Evidence Antibody microinjection, dominant-negative overexpression, and siRNA depletion with immunofluorescence readout

    PMID:12403812

    Open questions at the time
    • Which PCM1 domains bind each cargo was not mapped
    • No in vivo validation
  4. 2003 High

    Deletion mapping revealed that PCM1 self-aggregates via two N-terminal regions to form centriolar satellite granules, providing the structural basis for granule biogenesis.

    Evidence Overexpression of PCM1 deletion mutants with immunofluorescence in synchronized cells

    PMID:12571289

    Open questions at the time
    • In vitro reconstitution of self-assembly not performed
    • Post-translational regulation of multimerization not tested
  5. 2005 High

    Showing that PCM1 satellites deliver Nek2 kinase and its substrate C-Nap1 to centrosomes expanded the cargo repertoire beyond structural proteins to kinase signaling regulators.

    Evidence siRNA depletion of PCM1, FRAP, colocalization, and co-immunoprecipitation

    PMID:15659651

    Open questions at the time
    • Direct PCM1–Nek2 binding domain not mapped
    • Functional consequence for centrosome cohesion not fully tested
  6. 2005 Medium

    Identification of the t(8;9) PCM1–JAK2 fusion revealed that PCM1's coiled-coil dimerization domains can drive constitutive JAK2 oligomerization and tyrosine kinase activation in hematologic malignancies.

    Evidence RT-PCR, FISH, and domain sequence analysis in patient leukemia cells

    PMID:15805263

    Open questions at the time
    • Constitutive kinase activity inferred from domain architecture, not directly measured in this study
    • Oncogenic sufficiency not demonstrated by transformation assay
  7. 2008 High

    Discovery that CEP290 requires PCM1 for satellite localization and that both are needed for ciliogenesis and Rab8 ciliary targeting connected satellite transport to primary cilium biogenesis.

    Evidence Reciprocal co-IP, siRNA knockdown of PCM1 and CEP290, ciliogenesis and Rab8 targeting assays

    PMID:18772192

    Open questions at the time
    • Order of CEP290 vs PCM1 recruitment at cilia base not resolved
    • Relationship to ciliopathy mutations in CEP290 not tested
  8. 2008 High

    Demonstrating a PCM1–DISC1–BBS4 complex required for centrosomal cargo delivery and neuronal migration linked satellite biology to neurodevelopmental processes and psychiatric disease biology.

    Evidence Co-IP with domain mapping plus in utero RNAi epistasis in developing mouse cortex

    PMID:18762586

    Open questions at the time
    • Human genetic evidence for PCM1 in psychiatric disease not shown
    • Whether PCM1–DISC1 interaction is regulated by phosphorylation unknown
  9. 2010 High

    Hook3 recruitment to satellites via PCM1 was shown to be essential for interkinetic nuclear migration in embryonic neural progenitors, revealing a progenitor fate consequence of satellite disruption.

    Evidence Co-IP, in utero electroporation of dominant-negative constructs in mouse embryonic brain

    PMID:20152126

    Open questions at the time
    • Whether Hook3–PCM1 mediates dynein processivity directly not tested
    • Relevance to human cortical development not demonstrated
  10. 2011 High

    Huntingtin–HAP1–PCM1 complex formation was shown to regulate retrograde satellite trafficking and ciliogenesis, linking Huntington's disease pathology to satellite dysfunction.

    Evidence Co-IP, Htt conditional knockout mice, live-cell imaging, ciliogenesis assays

    PMID:21985783

    Open questions at the time
    • Whether polyQ-expanded HTT alters PCM1 interactions quantitatively not resolved
    • Ciliary phenotype contribution to HD symptoms not established
  11. 2013 High

    PCM1 was shown to recruit Plk1 to the centrosome in a CDK1-phosphorylation-primed, dynein-dependent manner, coupling PCM1 to mitotic cilia disassembly through Plk1–HDAC6 activation.

    Evidence shRNA depletion, co-IP, in vitro kinase assays, phosphorylation-dependent interaction mapping

    PMID:23345402

    Open questions at the time
    • Phosphorylation site(s) on PCM1 mediating Plk1 binding not mapped
    • Whether this pathway controls all cilia disassembly events or only premitotic unknown
  12. 2013 Medium

    PCM1–JAK2 fusion signaling was shown to activate STAT5 and upregulate SOCS2/SOCS3, confirming JAK2 as the functional kinase moiety and establishing downstream transcriptional targets.

    Evidence Lentiviral shRNA knockdown and JAK2 inhibitor treatment in PCM1–JAK2-expressing cell lines with gene expression profiling

    PMID:23372669

    Open questions at the time
    • Transformation sufficiency of the fusion not demonstrated
    • Patient cohort validation limited
  13. 2016 High

    PCM1 was identified as a critical sequesterer of the E3 ligase Mib1 at satellites, preventing Mib1-mediated degradation of the ciliogenesis factor Talpid3; this established a proteostasis gatekeeping function for satellites beyond simple cargo delivery.

    Evidence CRISPR PCM1 knockout, domain mapping, ubiquitylation assays, rescue experiments

    PMID:27146717

    Open questions at the time
    • Full set of Mib1 substrates protected by PCM1 not catalogued
    • Whether satellite-localized vs. cytoplasmic Mib1 pools are functionally distinct unknown
  14. 2016 High

    Plk4 phosphorylation of PCM1 at S372 was found to promote PCM1 dimerization and satellite assembly, revealing a kinase-dependent step controlling satellite biogenesis upstream of ciliogenesis.

    Evidence In vitro kinase assay, phosphomimetic/alanine mutants with ciliogenesis and satellite organization readouts

    PMID:26755742

    Open questions at the time
    • Whether S372 phosphorylation is constitutive or cell-cycle regulated not fully characterized
    • Crystal structure of dimerization interface lacking
  15. 2019 Medium

    SNX17-recruited USP9X was shown to deubiquitinate PCM1, counteracting Mib1, establishing a ubiquitin–deubiquitin balance controlling PCM1 protein levels and ciliogenesis competence.

    Evidence Co-IP, ubiquitination assays, siRNA knockdown with ciliogenesis readout

    PMID:31671755

    Open questions at the time
    • Endosomal versus cytoplasmic site of USP9X action on PCM1 not resolved
    • Single lab without independent replication
  16. 2019 Medium

    Zika virus was found to exploit Mib1-mediated degradation of PCM1 to disperse centriolar satellites, establishing PCM1 as a pathogen target and validating the Mib1-PCM1 axis in an infectious disease context.

    Evidence ZIKV infection in MIB1-KO vs. wild-type cells, proteasome inhibitor rescue, Western blot and immunofluorescence

    PMID:31666336

    Open questions at the time
    • Viral factor(s) that elevate Mib1 not identified
    • Whether satellite disruption benefits viral replication not shown
  17. 2020 Medium

    TCHP was shown to bind and stabilize PCM1 at satellites, and TCHP loss caused proteasome-dependent PCM1 degradation and impaired basal autophagic flux, linking satellite integrity to autophagy regulation.

    Evidence Co-IP, siRNA/knockout, autophagic flux assays with proteasome inhibitor

    PMID:32337819

    Open questions at the time
    • Mechanism by which TCHP protects PCM1 from ubiquitination not characterized
    • Single lab
  18. 2020 Medium

    PCM1 knockout mice exhibited progressive ciliary defects and reduced D2 receptor availability with behavioral phenotypes resistant to antipsychotic rescue, providing in vivo evidence for PCM1 in ciliary receptor trafficking and potential neuropsychiatric relevance.

    Evidence Pcm1 knockout mice, co-IP with D2R, behavioral assays, RNAseq

    PMID:33214552

    Open questions at the time
    • Whether D2R trafficking defect is direct or secondary to general ciliary failure unclear
    • Human genetic association with schizophrenia not established
  19. 2024 Medium

    PCM1 was identified as a redox-sensitive protein whose oxidation by reactive oxygen species causes satellite aggregation, autophagy marker accumulation, and ciliogenesis defects, broadening satellite regulation beyond kinase/ubiquitin signaling.

    Evidence Necrosulfonamide as ROS-producing chemical tool, CRISPR PCM1 deletion, autophagy flux and ciliogenesis assays

    PMID:38600973

    Open questions at the time
    • Specific cysteine residues oxidized not identified
    • Physiological ROS stimulus that triggers this pathway unknown
  20. 2025 High

    PCM1 was shown to regulate asymmetric endosome dynamics in neural progenitors by forming a Par-3/dynein complex on Notch ligand-containing endosomes, coupling centrosome asymmetry to progenitor self-renewal decisions conserved from zebrafish to human organoids.

    Evidence In vivo time-lapse imaging, expansion microscopy, co-IP, clonal analysis in zebrafish pcm1 KO, validated in human cortical organoids

    PMID:41315244

    Open questions at the time
    • Notch signaling outcome quantification in PCM1-null progenitors incomplete
    • Whether satellite-localized vs. endosome-localized PCM1 pools are distinct is not resolved
  21. 2025 Medium

    PCM1 was found to be required for manchette-mediated intracellular transport during spermatogenesis; Pcm1 knockout causes flagellogenesis failure and male infertility, extending satellite function to male germ cell differentiation.

    Evidence Pcm1 knockout mice, electron microscopy, co-IP, ICSI rescue

    PMID:40481240

    Open questions at the time
    • Specific cargo proteins transported via manchette by PCM1 not fully catalogued
    • Single lab
  22. 2025 Medium

    CCHCR1 was shown to depend on PCM1 and OFD1 for centrosomal localization and to recruit P-body components to promote ciliogenesis, expanding the functional repertoire of PCM1-dependent satellite clients.

    Evidence BioID-MS, co-IP, GST pulldown, AB-FRET, siRNA/CRISPR depletion with ciliogenesis readout

    PMID:40883668

    Open questions at the time
    • Functional relationship between P-body disassembly and cilia formation not mechanistically resolved
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • A structural model for PCM1 satellite granule architecture—including the spatial arrangement of self-multimerization domains, client-binding subdomains, and regulation of phase separation versus ordered assembly—remains unresolved.
  • No high-resolution structure of PCM1 or its multimerization interface
  • Whether satellites are phase-separated condensates or ordered polymeric assemblies not definitively established
  • Complete client proteome and hierarchical loading order not determined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 5 GO:0060090 molecular adaptor activity 4
Localization
GO:0005815 microtubule organizing center 6 GO:0005929 cilium 4 GO:0005856 cytoskeleton 3 GO:0005829 cytosol 2
Pathway
R-HSA-1852241 Organelle biogenesis and maintenance 5 R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 2 R-HSA-1640170 Cell Cycle 2 R-HSA-392499 Metabolism of proteins 2 R-HSA-9612973 Autophagy 2
Partners
BBS4CEP290DISC1HOOK3MIB1PLK1PLK4TCHP
Complex memberships
PCM1-DISC1-BBS4 complexPCM1-Par-3-dynein complexcentriolar satellites

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 PCM-1 localizes to centriolar satellites and is required for microtubule- and dynactin-dependent recruitment of centrin, pericentrin, and ninein to the centrosome; depletion of PCM-1 by antibody microinjection, dominant-negative overexpression, or siRNA disrupts radial microtubule organization without affecting microtubule nucleation. Antibody microinjection, dominant-negative overexpression, siRNA depletion, immunofluorescence microscopy The Journal of cell biology High 12403812
1994 PCM-1 is a 228-kDa centrosomal protein that associates tightly with the centrosome during G1, S, and early G2, then dissociates in late G2 and remains dispersed throughout mitosis, re-associating with centrosomes in G1 daughter cells, demonstrating cell cycle-dependent dynamics of pericentriolar material composition. Immunofluorescence microscopy with anti-recombinant PCM-1 antibodies across cell cycle stages The Journal of cell biology High 8120099
2003 PCM-1 granules (centriolar satellites) are formed by self-aggregation of PCM-1 through two distinct N-terminal regions; overexpressed C-terminal deletion mutants bind each other and recruit endogenous PCM-1 into large aggregates; granule assembly is cell-cycle regulated, disassembling during mitosis and reassembling in interphase. Overexpression of deletion mutants, immunofluorescence microscopy, cell cycle synchronization Journal of cell science High 12571289
2001 PCM-1 and pericentrin-B (kendrin) co-immunoprecipitate, indicating they form a functional complex; binding of both proteins to salt-stripped centrosomes requires intact microtubules, and immunodepletion of either protein does not inhibit microtubule nucleation from centrosomes. Co-immunoprecipitation, immunodepletion, microtubule nucleation assay, salt-stripped centrosome reconstitution Journal of cell science Medium 11171385
2005 PCM-1-containing centriolar satellites are required for centrosomal recruitment of Nek2 kinase and its substrate C-Nap1; Nek2 particles partially colocalize with PCM-1 and depletion of PCM-1 by siRNA reduces centrosomal Nek2; Nek2 recruitment also involves microtubule transport and localized proteasomal degradation. siRNA depletion of PCM-1, FRAP, immunofluorescence colocalization, co-immunoprecipitation Molecular biology of the cell High 15659651
2008 CEP290 interacts with PCM-1 and localizes to centriolar satellites in a PCM-1- and microtubule-dependent manner; CEP290 knockdown disrupts PCM-1 distribution and protein complex formation; both CEP290 and PCM-1 are required for ciliogenesis and ciliary targeting of Rab8. Co-immunoprecipitation, siRNA knockdown, immunofluorescence microscopy, ciliogenesis assay Human molecular genetics High 18772192
2008 PCM1 forms a complex with DISC1 and BBS4 at the centrosome through discrete binding domains in each protein; DISC1 and BBS4 are required synergistically for targeting PCM1 and cargo proteins (e.g., ninein) to the centrosome; suppression of PCM1 in the developing cerebral cortex causes neuronal migration defects phenocopied by DISC1 or BBS4 suppression. Co-immunoprecipitation, immunofluorescence, in utero RNAi, domain mapping Archives of general psychiatry High 18762586
2010 Hook3 is recruited to pericentriolar satellites through direct interaction with PCM1; disruption of the Hook3-PCM1 interaction in vivo impairs interkinetic nuclear migration in embryonic neural progenitors, causing overproduction of neurons and premature depletion of the neural progenitor pool. Co-immunoprecipitation, in utero electroporation, immunofluorescence, in vivo dominant-negative perturbation Neuron High 20152126
2011 Wild-type huntingtin (HTT) interacts with PCM1 through HAP1 to regulate retrograde trafficking of PCM1 to the centrosome and normal ciliogenesis; loss of Htt impairs PCM1 retrograde trafficking and reduces primary cilia formation; pathogenic polyQ-expanded HTT causes centrosomal accumulation of PCM1 and abnormally long primary cilia. Co-immunoprecipitation, conditional knockout mouse models, live-cell imaging, immunofluorescence, ciliogenesis assay The Journal of clinical investigation High 21985783
2013 PCM1 acts upstream of Plk1 and recruits it to the pericentriolar matrix in a dynein-dynactin-dependent manner; this interaction is phosphorylation-dependent with CDK1 as the priming kinase; centrosomal Plk1 then activates HDAC6 to promote ciliary deacetylation and primary cilia disassembly before mitotic entry. shRNA depletion, co-immunoprecipitation, kinase assays, phosphorylation-dependent interaction analysis, immunofluorescence Journal of cell science High 23345402
2016 PCM1 is essential for tethering the E3 ubiquitin ligase Mindbomb1 (Mib1) to centriolar satellites; in the absence of PCM1, Mib1 poly-ubiquitylates and destabilizes Talpid3, blocking recruitment of Rab8-associated ciliary vesicles and ciliogenesis; an N-terminal domain of PCM1 is sufficient for restoring satellite localization of certain proteins and ciliogenesis. PCM1 gene deletion (CRISPR), domain mapping, ubiquitylation assay, co-immunoprecipitation, rescue experiments, immunofluorescence eLife High 27146717
2016 Plk4 kinase phosphorylates PCM1 at the conserved S372 residue, promoting PCM1 dimerization and interaction with other satellite components; non-phosphorylatable PCM1-S372A recapitulates Plk4 depletion phenotypes (satellite dispersal, ciliogenesis defects), while phosphomimetic S372E partially rescues satellite organization and ciliogenesis in PCM1-depleted cells. In vitro kinase assay, phosphomimetic/alanine mutants, immunofluorescence, ciliogenesis assay, co-immunoprecipitation EMBO reports High 26755742
2019 SNX17 recruits the deubiquitinating enzyme USP9X to antagonize MIB1-induced ubiquitination and proteasomal degradation of PCM1; SNX17 deficiency leads to enhanced degradation of USP9X and PCM1 and disrupts ciliogenesis upon serum starvation. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, immunofluorescence, ciliogenesis assay Cells Medium 31671755
2019 Zika virus infection increases Mindbomb1 (MIB1) levels, which promotes MIB1-mediated poly-ubiquitination and proteasomal degradation of PCM1 and CEP131, causing dispersion of centriolar satellite granules while leaving centrioles intact; MIB1 knockout cells are refractory to ZIKV-induced PCM1 degradation and satellite dispersion. Viral infection, MIB1 knockout cells, proteasome inhibitor (MG132), Western blot, immunofluorescence The Journal of biological chemistry Medium 31666336
2020 Trichoplein (TCHP) localizes to centriolar satellites and binds PCM1, stabilizing it; loss of TCHP causes delocalization and proteasome-dependent degradation of PCM1 and loss of PCM1's binding partner GABARAP, impairing autophagic flux under basal conditions. Co-immunoprecipitation, siRNA/knockout, immunofluorescence, autophagic flux assay, proteasome inhibitor treatment EMBO reports Medium 32337819
2020 Ablation of PCM1 in mice leads to progressive ciliary defects, and PCM1 associates with dopamine D2 receptors (D2Rs) as shown by immunoprecipitation; PCM1-null mice show decreased available D2R levels and failure of antipsychotic drugs to rescue adult behavioral defects. Mouse PCM1 knockout, immunoprecipitation, behavioral assays, RNAseq Nature communications Medium 33214552
2024 Necrosulfonamide (NSA) functions as a redox cycler that oxidizes and aggregates PCM1 alongside select satellite partners independently of MLKL; NSA-mediated ROS production disrupts ciliogenesis and leads to accumulation of autophagy markers, effects partially alleviated by PCM1 deletion, identifying PCM1 as a redox sensor in centriolar satellite biology. Chemical perturbation, ROS assays, PCM1 deletion (CRISPR), immunofluorescence, autophagy flux assays iScience Medium 38600973
2025 In zebrafish radial glia progenitors, Pcm1 is asymmetrically distributed at centrosomes and detected on Notch ligand-containing endosomes in a complex with polarity regulator Par-3 and dynein motor; loss of pcm1 disrupts Rab5b-to-Rab11a endosome transition and Par-3/dynein macromolecular complex assembly, increasing neuronal differentiation at the expense of progenitor self-renewal; PARD3-PCM1-CEP83-RAB11 associations are conserved in human cortical brain organoids. In vivo time-lapse imaging, nanoscale expansion microscopy, co-immunoprecipitation, clonal analysis, zebrafish pcm1 knockout, human brain organoids Nature communications High 41315244
2025 PCM1 orchestrates centrosomal and flagellar protein transport during sperm maturation; Pcm1 knockout mice exhibit disorganized manchette and head-tail coupling apparatus, defective flagellogenesis, and male infertility; PCM1 binds centrosomal proteins and governs their translocation via intra-manchette transport for centrosome remodeling and axoneme biogenesis. Pcm1 knockout mice, co-immunoprecipitation, immunofluorescence, electron microscopy, ICSI experiments Communications biology Medium 40481240
2025 Centriolar satellites assemble via a hierarchical pathway initiated by PCM1 scaffold multimerization followed by regulated client recruitment; PCM1 intrinsically assembles into granules through self-multimerization modulated by the cytoskeleton; PCM1 and its clients occupy distinct subdomains with different compositions and dynamics; perturbing PCM1 multimerization impairs ciliary signaling. In vitro biogenesis assays, cellular assembly assays, high-resolution imaging, spatiotemporal quantification of granule properties bioRxivpreprint Medium
2005 The t(8;9)(p22;p24) translocation fuses PCM1 coiled-coil domains to the entire tyrosine kinase domain of JAK2, producing a PCM1-JAK2 chimeric protein; the predicted coiled-coil domains of PCM1 likely promote JAK2 oligomerization and constitutive tyrosine kinase activation. RT-PCR, RACE-PCR, FISH, sequence analysis, prediction of constitutive activation by coiled-coil oligomerization Cancer research Medium 15805263
2013 PCM1-JAK2 fusion signals through STAT5 to upregulate SOCS2 and SOCS3; lentiviral knockdown of PCM1-JAK2 inhibited these top upregulated genes, and treatment with a selective JAK2 inhibitor confirmed JAK2 as the active kinase moiety; GATA3 expression silenced in aggressive lymphoma cells is partially restored by PCM1-JAK2 knockdown. Lentiviral shRNA knockdown, JAK2 inhibitor treatment, gene expression profiling, PCM1-JAK2 fusion cell lines PloS one Medium 23372669
2025 CCHCR1 interacts with PCM1 and OFD1; the centrosomal localization of CCHCR1 is determined by both OFD1 and PCM1; CCHCR1 recruits P-body proteins (via EDC4) to the centrosome and depletion of CCHCR1 or P-body components impairs ciliogenesis, placing PCM1 upstream of CCHCR1 centrosomal targeting. BioID-mass spectrometry, co-immunoprecipitation, GST pulldown, AB-FRET, siRNA/CRISPR knockdown/knockout, immunofluorescence Cellular & molecular biology letters Medium 40883668

Source papers

Stage 0 corpus · 63 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Assembly of centrosomal proteins and microtubule organization depends on PCM-1. The Journal of cell biology 407 12403812
2008 CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium. Human molecular genetics 243 18772192
2005 The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2. Cancer research 226 15805263
1994 PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution. The Journal of cell biology 143 8120099
2011 Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. The Journal of clinical investigation 130 21985783
2013 PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry. Journal of cell science 127 23345402
2008 Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Archives of general psychiatry 117 18762586
2016 Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis. eLife 103 27146717
2003 Non-membranous granular organelle consisting of PCM-1: subcellular distribution and cell-cycle-dependent assembly/disassembly. Journal of cell science 101 12571289
2005 The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. Oncogene 100 16091753
1996 Molecular and biochemical analysis of RET/PTC4, a novel oncogenic rearrangement between RET and ELE1 genes, in a post-Chernobyl papillary thyroid cancer. Oncogene 100 8806699
2010 Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron 98 20152126
2005 Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation. Molecular biology of the cell 98 15659651
2006 Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia. Archives of general psychiatry 72 16894060
2001 Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1. Journal of cell science 70 11171385
2014 Limited duration of complete remission on ruxolitinib in myeloid neoplasms with PCM1-JAK2 and BCR-JAK2 fusion genes. Annals of hematology 63 25260694
2007 Recruitment of P-TEFb (Cdk9-Pch1) to chromatin by the cap-methyl transferase Pcm1 in fission yeast. The EMBO journal 58 17332744
2021 Myeloid/Lymphoid Neoplasms Associated With Eosinophilia and Rearrangements of PDGFRA, PDGFRB, or FGFR1 or With PCM1-JAK2. American journal of clinical pathology 53 33367495
2020 Response to tyrosine kinase inhibitors in myeloid neoplasms associated with PCM1-JAK2, BCR-JAK2 and ETV6-ABL1 fusion genes. American journal of hematology 53 32279331
2016 A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation. EMBO reports 50 26755742
2016 PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide. Translational oncology 49 27661404
2006 Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo. Molecular and cellular biology 47 16428435
2013 t(8;9)(p22;p24)/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5. PloS one 40 23372669
2013 Hematologic malignancies with PCM1-JAK2 gene fusion share characteristics with myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1. Annals of hematology 31 23400675
2021 Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle. PLoS genetics 22 34752468
2019 SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis. Cells 21 31671755
2010 PCM1-JAK2-fusion: a potential treatment target in myelodysplastic-myeloproliferative and other hemato-lymphoid neoplasms. Expert opinion on therapeutic targets 20 21091042
2020 Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. EMBO reports 19 32337819
2020 PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. Nature communications 19 33214552
2019 Zika virus increases mind bomb 1 levels, causing degradation of pericentriolar material 1 (PCM1) and dispersion of PCM1-containing granules from the centrosome. The Journal of biological chemistry 18 31666336
2022 PCM1-JAK2 Fusion Tyrosine Kinase Gene-Related Neoplasia: A Systematic Review of the Clinical Literature. The oncologist 15 35472244
1999 Do damaged proteins accumulate in Caenorhabditis elegans L-isoaspartate methyltransferase (pcm-1) deletion mutants? Archives of biochemistry and biophysics 15 10190976
2011 No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. Schizophrenia research 13 21481569
1995 Characterization of the basic replicon of pCM1, a narrow-host-range plasmid from the moderate halophile Chromohalobacter marismortui. Journal of bacteriology 13 7768853
2011 H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4. The EMBO journal 12 22139357
2024 Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes. The FEBS journal 11 38825736
2023 Two activating phosphorylation sites of Pbs2 MAP2K in the yeast HOG pathway are differentially dephosphorylated by four PP2C phosphatases Ptc1-Ptc4. The Journal of biological chemistry 10 36870684
2022 PCM1 labeling reveals myonuclear and nuclear dynamics in skeletal muscle across species. American journal of physiology. Cell physiology 10 36409178
2019 Centrosome-derived microtubule radial array, PCM-1 protein, and primary cilia formation. Protoplasma 10 31079229
2013 A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM-1) protein binds β-amyloid (Aβ1-42 ) oligomers. Journal of neurochemistry 10 23432034
2023 Rare and potentially fatal - Cytogenetically cryptic TNIP1::PDGFRB and PCM1::FGFR1 fusion leading to myeloid/lymphoid neoplasms with eosinophilia in children. Cancer genetics 9 36657267
2010 PCM1 and schizophrenia: a replication study in the Northern Swedish population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 9 20468070
2007 Autophagy and insulin/TOR signaling in Caenorhabditis elegans pcm-1 protein repair mutants. Autophagy 9 17404495
2019 What went wrong with variant effect predictor performance for the PCM1 challenge. Human mutation 8 31268618
2022 Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1-JAK2 positive myeloid sarcoma and acute B-lymphoblastic leukemia. Clinical case reports 7 35028141
2021 LncRNA-ENST00000421645 promotes T cells to secrete IFN-γ by sponging PCM1 in neurosyphilis. Epigenomics 7 34382410
2012 Identification of protein kinase C inhibitory activity associated with a polypeptide isolated from a phage display system with homology to PCM-1, the pericentriolar material-1 protein. Biochemical and biophysical research communications 7 22732405
1998 Localization of autoepitopes on the PCM-1 autoantigen using scleroderma sera with autoantibodies against the centrosome. Molecular biology reports 6 9540072
2022 PCM1::JAK2 fusion associates with an atypical form of mycosis fungoides. Virchows Archiv : an international journal of pathology 5 35786767
2021 Nanopore sequencing for the screening of myeloid and lymphoid neoplasms with eosinophilia and rearrangement of PDGFRα, PDGFRβ, FGFR1 or PCM1-JAK2. Biomarker research 4 34772467
2025 PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation. Communications biology 3 40481240
2019 RNA Sequencing Analysis for the Identification of a PCM1/PDGFRB Fusion Gene Responsive to Imatinib. Acta haematologica 3 31085913
2012 A huntingtin-HAP1-PCM1 pathway in ciliogenesis. Expert review of proteomics 3 22292820
2025 PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate. Nature communications 2 41315244
2024 Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy. iScience 2 38600973
2024 PCM1 conveys centrosome asymmetry to polarized endosome dynamics in regulating daughter cell fate. bioRxiv : the preprint server for biology 1 38948739
2023 NKD1 targeting PCM1 regulates the therapeutic effects of homoharringtonine on colorectal cancer. Molecular biology reports 1 37338734
2022 Myeloid Neoplasm with PCM1-PDGFRB Transcript Responded to Low-Dose Imatinib: One Case Report with Literature Review. Acta haematologica 1 35340014
2026 A case report and a literature review of Myeloid/Lymphoid Neoplasm with Eosinophilia and PCM1::JAK2 rearrangement representing as B-cell acute lymphoblastic leukemia B-ALL. Annals of hematology 0 41530508
2025 A Case of Myeloproliferative Neoplasm with Eosinophilia Associated with PCM1-JAK2 Rearrangement. Case reports in oncology 0 39980500
2025 CCHCR1 links P-body proteins to the centrosome and is required for ciliogenesis through interacting with OFD1 and PCM1. Cellular & molecular biology letters 0 40883668
2024 A rare case of hypereosinophilic endomyocardial fibrosis due to PCM1-JAK2. The British journal of cardiology 0 41846857
2006 Expression of citrate permease gene of plasmid pCM1 isolated from Lactococcus lactis subsp. lactis biovar diacetylactis NIAI N-7 in Lactobacillus casei L-49-4. Applied microbiology and biotechnology 0 17139509