Affinage

TCHP

Trichoplein keratin filament-binding protein · UniProt Q9BT92

Round 2 corrected
Length
498 aa
Mass
61.1 kDa
Annotated
2026-04-28
81 papers in source corpus 8 papers cited in narrative 8 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TCHP (trichoplein) is a centrosome-associated scaffold protein that coordinates ciliogenesis, microtubule organization, mitochondrial dynamics, and mitotic fidelity. At the subdistal-to-medial zone of centrioles, TCHP forms a complex with Odf2 and ninein to anchor microtubules and activates Aurora A kinase to suppress primary cilium formation in proliferating cells; CRL3-KCTD17-mediated ubiquitination and proteasomal degradation of TCHP at K50/K57 terminates this suppression, permitting axoneme extension during ciliogenesis (PMID:21325031, PMID:25270598, PMID:26880200). TCHP also localizes to ER–mitochondria contact sites where it regulates mitochondrial morphology and tethering in an Mfn2-dependent manner, functioning as a downstream effector of decorin-evoked mitophagy (PMID:20930847, PMID:24403067). In cancer, TCHP interacts with Mad2 to support spindle assembly checkpoint function and chromosomal stability, and when overexpressed drives oncogenesis through liquid–liquid phase separation condensates with AURKA at centrosomes that enhance AURKA activation (PMID:32316593, PMID:42034602).

Mechanistic history

Synthesis pass · year-by-year structured walk · 7 steps
  1. 2010 High

    The first mechanistic insight into TCHP revealed an unexpected non-centrosomal role: TCHP resides at ER–mitochondria contact sites and modulates their tethering and mitochondrial fission through Mfn2, establishing it as a regulator of organelle communication and Ca2+-dependent apoptosis.

    Evidence Subcellular fractionation, immunostaining, genetic knockdown/overexpression, and Mfn2 epistasis in mammalian cells

    PMID:20930847

    Open questions at the time
    • Direct binding interface between TCHP and Mfn2 not mapped
    • Whether ER–mitochondria tethering function operates independently of centrosomal roles is unknown
    • In vivo validation of the ER–mitochondria phenotype not performed
  2. 2011 High

    Establishing TCHP's centrosomal function, direct binding to Odf2 and ninein was demonstrated, placing TCHP in a hierarchical complex (Odf2 → TCHP → ninein) required for microtubule anchoring at the centrosome.

    Evidence Co-immunoprecipitation, reciprocal siRNA depletion epistasis, and functional MT-anchoring assays

    PMID:21325031

    Open questions at the time
    • Structural basis of the Odf2–TCHP–ninein interaction not resolved
    • Whether TCHP's MT-anchoring role is cell-type specific remains untested
  3. 2014 High

    Two independent studies resolved how TCHP is removed to permit ciliogenesis and linked TCHP to mitophagy: CRL3-KCTD17 ubiquitinates TCHP at K50/K57 to trigger its proteasomal degradation and inactivate Aurora A, initiating axoneme extension; separately, PGC-1α stabilizes TCHP mRNA to increase its protein levels, which are required for decorin-evoked mitophagy and suppression of VEGFA.

    Evidence Global E3 screen with non-ubiquitylatable K50/57R mutant and ciliogenesis rescue (ciliogenesis); RIP, siRNA, mitophagy and VEGFA assays in breast carcinoma cells (mitophagy)

    PMID:24403067 PMID:25270598

    Open questions at the time
    • Whether TCHP directly activates Aurora A or acts through an intermediary scaffold is not fully defined
    • Mitophagy function of TCHP established only in breast carcinoma cells by a single lab
    • Relationship between TCHP's ciliogenesis-suppressive and mitophagy-promoting functions not clarified
  4. 2016 High

    Ndel1 was placed upstream of TCHP in the ciliogenesis pathway: serum starvation triggers transient Ndel1 degradation, which precedes TCHP loss from the mother centriole, establishing a temporal cascade (Ndel1 → TCHP → Aurora A) that gates ciliogenesis initiation.

    Evidence siRNA epistasis with rescue, immunofluorescence, and in vivo validation in Ndel1-hypomorphic mouse kidneys

    PMID:26880200

    Open questions at the time
    • How Ndel1 physically stabilizes TCHP at the mother centriole is not determined
    • Whether Ndel1-TCHP epistasis operates in tissues beyond kidney tubular epithelium is unknown
  5. 2020 Medium

    TCHP was linked to mitotic fidelity: its depletion causes chromosome mis-segregation and DNA damage, and it interacts with the spindle assembly checkpoint protein Mad2, with loss reducing Mad2 and Cyclin B1 levels.

    Evidence Co-immunoprecipitation, siRNA depletion, chromosome segregation assays and DNA damage markers in cancer cells

    PMID:32316593

    Open questions at the time
    • Mad2 interaction demonstrated by a single Co-IP without reciprocal pull-down or structural validation
    • Whether TCHP regulates Mad2 stability versus localization is not distinguished
    • Unclear whether chromosomal instability arises from SAC defects or from centrosomal/MT-anchoring dysfunction
  6. 2022 Medium

    Super-resolution imaging extended the chromosomal instability phenotype by showing that TCHP depletion alters 3D telomere architecture and nuclear organization, connecting its function to higher-order genome maintenance.

    Evidence 3D structured illumination microscopy in TCHP-depleted HCT116 cells

    PMID:35884905

    Open questions at the time
    • Single imaging method without independent functional confirmation of telomere dysfunction
    • Whether telomere architectural changes are a direct consequence of TCHP loss or secondary to chromosomal instability is unresolved
  7. 2026 High

    In hepatocellular carcinoma, TCHP was shown to form LLPS condensates with AURKA at centrosomes, enhancing AURKA activation and promoting oncogenesis; TCHP overexpression accelerated hepatocarcinogenesis in mice, and its inhibition synergized with the AURKA inhibitor alisertib.

    Evidence Mouse overexpression hepatocarcinogenesis model, LLPS condensate assays, AURKA activity readouts, and alisertib drug synergy

    PMID:42034602

    Open questions at the time
    • LLPS condensate composition beyond TCHP–AURKA not characterized
    • Whether LLPS-mediated AURKA activation is relevant in non-cancerous proliferating cells is unknown
    • Structural determinants of TCHP phase separation not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how TCHP's centrosomal, ER–mitochondria, and SAC-related functions are coordinated—whether distinct pools of TCHP operate at different subcellular sites and how they are partitioned in different cell states.
  • No study has simultaneously tracked TCHP pools at centrosomes, ER–mitochondria contacts, and the spindle
  • Post-translational modification map beyond K50/K57 ubiquitination is incomplete
  • No structural model of TCHP exists

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 2 GO:0008092 cytoskeletal protein binding 1
Localization
GO:0005815 microtubule organizing center 4 GO:0005739 mitochondrion 2 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-1640170 Cell Cycle 2 R-HSA-1643685 Disease 1 R-HSA-9612973 Autophagy 1
Partners
AURKAKCTD17MAD2L1MFN2NDEL1NINODF2
Complex memberships
Odf2–trichoplein–ninein centrosomal complex

Evidence

Reading pass · 8 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 Trichoplein/mitostatin (TpMs/TCHP) is present at the interface between mitochondria and endoplasmic reticulum (ER), as shown by subcellular fractionation and immunostaining. Its expression promotes mitochondrial fragmentation and loosens ER-mitochondria tethering, while its silencing has opposite effects. This tethering regulation requires Mitofusin 2 (Mfn2) and functionally inhibits apoptosis triggered by Ca2+-dependent stimuli that require ER-mitochondria juxtaposition. Subcellular fractionation, immunostaining, genetic knockdown/overexpression, Ca2+-dependent apoptosis assays, epistasis with Mfn2 EMBO reports High 20930847
2011 Trichoplein (TCHP) localizes to the subdistal-to-medial zone of both mother and daughter centrioles in proliferating cells. It directly binds the centrosomal proteins Odf2 and ninein. Trichoplein depletion abolishes ninein recruitment at the subdistal end (but not Odf2), while Odf2 depletion prevents trichoplein recruitment to the mother centriole. Both trichoplein and Odf2 depletion impair microtubule anchoring at the centrosome, placing trichoplein in a complex with Odf2 and ninein that controls MT-anchoring activity. Immunocytochemistry, co-immunoprecipitation/binding assays, siRNA knockdown with functional microtubule anchoring readout Journal of cell science High 21325031
2014 The CRL3-KCTD17 ubiquitin E3 ligase complex polyubiquitylates trichoplein (TCHP) at K50/K57 on mother centrioles, targeting it for proteasomal degradation. This ubiquitin-proteasome-mediated removal of trichoplein inactivates Aurora A kinase at the mother centriole, thereby initiating the first step of axoneme extension during ciliogenesis. Proteasome inhibition or expression of non-ubiquitylatable trichoplein (K50/57R) blocks ciliogenesis at the axoneme extension step. KCTD17 was identified as the substrate adaptor through two-step global E3 screening. E3 ligase screen, mutagenesis (K50/57R non-ubiquitylatable mutant), proteasome inhibitor treatment, siRNA knockdown, ciliogenesis assays Nature communications High 25270598
2014 Soluble decorin induces mitophagy in breast carcinoma cells through a pathway involving PGC-1α and mitostatin (TpMs/TCHP). PGC-1α binds MITOSTATIN mRNA to stabilize it, increasing mitostatin protein levels. Depletion of mitostatin blocks decorin-evoked or rapamycin-evoked mitophagy and increases VEGFA production, establishing mitostatin as a key regulator of tumor cell mitophagy and angiostasis downstream of the decorin/Met axis. siRNA knockdown, mRNA stability assays, RIP (RNA immunoprecipitation), mitophagy assays, VEGFA measurement The Journal of biological chemistry Medium 24403067
2016 Ndel1, a dynein modulator, localizes at the subdistal appendage of the mother centriole and acts as an upstream regulator of the trichoplein (TCHP)–Aurora A pathway. In proliferating cells, Ndel1 depletion reduces trichoplein at the mother centriole and induces unscheduled primary cilia formation; this is rescued by forced trichoplein expression or KCTD17 co-knockdown. Serum starvation triggers transient Ndel1 degradation, which precedes trichoplein disappearance and allows ciliogenesis. Forced Ndel1 expression suppresses trichoplein degradation and axoneme extension, mimicking trichoplein overexpression. siRNA knockdown, overexpression rescue, immunofluorescence, in vivo Ndel1-hypomorphic mouse model (kidney tubular epithelia) The Journal of cell biology High 26880200
2020 Silencing of TpMs (TCHP) in cancer cells causes chromosome mis-segregation, DNA damage, and chromosomal instability. TpMs interacts with Mad2, and its depletion results in decreased levels of Mad2 and Cyclin B1 proteins, consistent with defective spindle assembly checkpoint activation and aberrant mitotic progression. siRNA knockdown, chromosome segregation assays, DNA damage markers, co-immunoprecipitation (TpMs–Mad2 interaction), Western blot for Mad2 and Cyclin B1 Cancers Medium 32316593
2022 TpMs (TCHP) depletion causes alterations in the 3D architecture of telomeres and changes the spatial arrangement of chromosomes and other nuclear components in colon cancer HCT116 cells, as revealed by 3D structured illumination microscopy. These nuclear architecture changes are consistent with the chromosomal instability phenotype and connect TpMs tumor suppressor function to maintenance of proper telomere and nuclear organization. 3D structured illumination microscopy (3D-SIM), 3D imaging of telomere architecture in TpMs-depleted cells Biomedicines Medium 35884905
2026 TCHP (trichoplein) is markedly upregulated in hepatocellular carcinoma. Mechanistically, TCHP localizes to centrosomes and promotes liquid-liquid phase separation (LLPS)-driven condensate formation with Aurora A kinase (AURKA), thereby enhancing AURKA activation and safeguarding mitotic fidelity. TCHP overexpression accelerates hepatocarcinogenesis in mice, while its depletion suppresses tumor growth by inducing mitotic defects. TCHP inhibition also sensitizes liver cancer cells to the AURKA inhibitor alisertib, defining a TCHP–AURKA oncogenic axis. Mouse hepatocarcinogenesis overexpression model, siRNA/shRNA depletion, LLPS condensate assays, co-localization at centrosomes, AURKA activity assays, drug synergy with alisertib Cell death & disease High 42034602

Source papers

Stage 0 corpus · 81 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Towards a proteome-scale map of the human protein-protein interaction network. Nature 2090 16189514
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2013 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Science signaling 383 24255178
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2010 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell 318 21145461
2017 Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proceedings of the National Academy of Sciences of the United States of America 282 28611215
2011 Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. The EMBO journal 265 21399614
2021 Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Cell metabolism 239 34800366
2014 Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. Journal of proteomics 215 25281560
2016 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nature communications 211 27173435
2011 Next-generation sequencing to generate interactome datasets. Nature methods 200 21516116
2015 BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates. Molecular & cellular proteomics : MCP 149 25900982
2014 Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. Nature communications 116 25270598
2007 Toward a confocal subcellular atlas of the human proteome. Molecular & cellular proteomics : MCP 114 18029348
2010 Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition. EMBO reports 112 20930847
2014 Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin. The Journal of biological chemistry 82 24403067
2017 Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy. Matrix biology : journal of the International Society for Matrix Biology 73 29080840
2021 Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. Molecular cell 64 33957083
2019 Functionally graded and multi-morphology sheet TPMS lattices: Design, manufacturing, and mechanical properties. Journal of the mechanical behavior of biomedical materials 63 31877523
2016 Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. The Journal of cell biology 62 26880200
2011 Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. Journal of cell science 62 21325031
2019 Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Nature communications 60 31515488
2020 On the permeability of TPMS scaffolds. Journal of the mechanical behavior of biomedical materials 43 32957226
2019 Permeability versus Design in TPMS Scaffolds. Materials (Basel, Switzerland) 42 31013656
2023 3D printed TPMS structural PLA/GO scaffold: Process parameter optimization, porous structure, mechanical and biological properties. Journal of the mechanical behavior of biomedical materials 41 37099921
2020 In-silico simulated prototype-patients using TPMS technology to study a potential adverse effect of sacubitril and valsartan. PloS one 39 32053711
2014 Investigating internal architecture effect in plastic deformation and failure for TPMS-based scaffolds using simulation methods and experimental procedure. Materials science & engineering. C, Materials for biological applications 32 25175253
2013 Locus-specific proteomics by TChP: targeted chromatin purification. Cell reports 31 23911284
2023 The design of strut/TPMS-based pore geometries in bioceramic scaffolds guiding osteogenesis and angiogenesis in bone regeneration. Materials today. Bio 29 37273795
2022 Mechanical Characterisation and Numerical Modelling of TPMS-Based Gyroid and Diamond Ti6Al4V Scaffolds for Bone Implants: An Integrated Approach for Translational Consideration. Bioengineering (Basel, Switzerland) 25 36290472
2016 Retrospective study of the efficacy and safety of neoadjuvant docetaxel, carboplatin, trastuzumab/pertuzumab (TCH-P) in nonmetastatic HER2-positive breast cancer. Breast cancer research and treatment 21 27324504
2022 Real World Evidence of Neoadjuvant Docetaxel/Carboplatin/Trastuzumab/Pertuzumab (TCHP) in Patients with HER2-Positive Early or Locally Advanced Breast Cancer: A Single-Institutional Clinical Experience. Cancer research and treatment 14 35008143
2022 Compression Performance and Failure Analysis of 3D-Printed Carbon Fiber/PLA Composite TPMS Lattice Structures. Polymers 14 36365590
2022 A biomechanical evaluation on Cubic, Octet, and TPMS gyroid Ti6Al4V lattice structures fabricated by selective laser melting and the effects of their debris on human osteoblast-like cells. Biomaterials advances 12 35929262
2021 Double-Level Energy Absorption of 3D Printed TPMS Cellular Structures via Wall Thickness Gradient Design. Materials (Basel, Switzerland) 11 34771788
2023 The effects of sheet and network solid structures of similar TPMS scaffold architectures on permeability, wall shear stress, and velocity: A CFD analysis. Medical engineering & physics 9 37536832
2024 Design, Stereolithographic 3D Printing, and Characterization of TPMS Scaffolds. Materials (Basel, Switzerland) 8 38591518
2024 TPMS-based auxetic structure for high-performance airless tires with variable stiffness depending on deformation. Scientific reports 7 38763924
2020 Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells. Cancers 7 32316593
2023 Mechanical Properties and Energy Absorption Abilities of Diamond TPMS Cylindrical Structures Fabricated by Selective Laser Melting with 316L Stainless Steel. Materials (Basel, Switzerland) 6 37110031
2025 TPMS-Gyroid Scaffold-Mediated Up-Regulation of ITGB1 for Enhanced Cell Adhesion and Immune-Modulatory Osteogenesis. Advanced healthcare materials 4 39853929
2024 Biomolecule-grafted GO enhanced the mechanical and biological properties of 3D printed PLA scaffolds with TPMS porous structure. Journal of the mechanical behavior of biomedical materials 4 38981181
2024 Definition, Fabrication, and Compression Testing of Sandwich Structures with Novel TPMS-Based Cores. Materials (Basel, Switzerland) 4 39517426
2013 TPMS: a set of utilities for querying collections of gene trees. BMC bioinformatics 4 23530580
2025 Multifunctional gradations of TPMS architected heat exchanger for enhancements in flow and heat exchange performances. Scientific reports 3 40481180
2023 Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure. Biomimetics (Basel, Switzerland) 3 36810400
2022 Impact of Dose Intensity on Pathologic Complete Response Rate in HER2-Positive Breast Cancer Patients Receiving Neoadjuvant Docetaxel, Carboplatin, Trastuzumab and Pertuzumab (TCHP). Targeted oncology 3 35325355
2022 Anaemia and pathologic complete response rate according to carboplatin dose in HER2+ breast cancer treated with neoadjuvant TCHP. Cancer medicine 3 35837812
2025 Investigation on mechanical characteristics of modified TPMS primitive PLA-CF mechanical metamaterials. Scientific reports 2 40789890
2025 Visible Light Induced DLP-Printed Oxygen-Releasing TPMS Scaffolds Mitigate Early Hypoxia in Bone Defects. Advanced healthcare materials 2 40985752
2024 Topology Optimization Via Spatially-Varying TPMS. IEEE transactions on visualization and computer graphics 2 37074903
2024 Optimization of functionally graded solid-network TPMS meta-biomaterials. Journal of the mechanical behavior of biomedical materials 2 38833782
2024 Design and study of additively manufactured Three periodic minimal surface (TPMS) structured porous titanium interbody cage. Heliyon 2 39364254
2022 Telomere Dysfunction Is Associated with Altered DNA Organization in Trichoplein/Tchp/Mitostatin (TpMs) Depleted Cells. Biomedicines 2 35884905
2025 Structural optimization, compressive strength analysis, and application exploration of triply periodic minimal surfaces (TPMS) in interior design. Scientific reports 1 40164673
2025 Multi-Objective Machine Learning Optimization of Cylindrical TPMS Lattices for Bone Implants. Biomimetics (Basel, Switzerland) 1 40710288
2025 Investigating Experimental and Computational Fluid Dynamics of 3D-Printed TPMS and Lattice Porous Structures. Micromachines 1 40872390
2025 Uniform and multi-morphology graded TPMS structures: Design strategies, 3D printing and mechanical properties. Journal of the mechanical behavior of biomedical materials 1 41014955
2024 Optimization of Environment-Friendly and Sustainable Polylactic Acid (PLA)-Constructed Triply Periodic Minimal Surface (TPMS)-Based Gyroid Structures. Polymers 1 38675094
2024 Improvement in Active Cell Proliferation Area at Higher Permeability With Novel TPMS Lattice Structure. Journal of biomechanical engineering 1 39152719
2023 Immune repertoire and responses to neoadjuvant TCHP therapy in HER2-positive breast cancer. Therapeutic advances in medical oncology 1 36865681
2023 Impact of relative dose intensity on pathologic complete response in human epidermal growth factor receptor 2 positive breast cancer patients receiving neoadjuvant TCHP. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 1 37936380
2026 The Effect of Non-Uniform Material Distribution on the Bending Strength and Energy Absorption of TPMS Structures. Polymers 0 41754646
2026 Sub-Unit-Cell Logic Governs Transport in TPMS Architectures. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 41802135
2026 Absorption-Dominant Electromagnetic Interference Shielding of Ti3C2Tx MXene-Coated and Fe3O4-Integrated TPMS Composites with Coupled Gradient Conductivity and Size-Graded Structure. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 41808527
2026 Comparative Torsional Properties via Numerical Simulation of Triply Periodic Minimal Surfaces (TPMS): Diamond, Gyroid and Primitive Structures. Polymers 0 41901867
2026 Bridging Clinical Trials to Real-World Clinical Practice: TCHP Neoadjuvant Therapy Outcomes in HER2-Positive Breast Cancer. Breast cancer (Dove Medical Press) 0 41982224
2026 TCHP drives hepatocarcinogenesis through LLPS-mediated AURKA condensation and enables synergistic therapy. Cell death & disease 0 42034602
2025 Customization of existing TPMS lattices to enhance biocompatibility and active cell proliferation area. Medical engineering & physics 0 40925693
2025 3D TPMS curvature accelerated osteogenesis by enhancing permeability and directing cell orientation. Biofabrication 0 41067251
2024 Analysis of mechanical characteristics and permeability of TPMS and Voronoi porous structure for bone scaffold. Computer methods in biomechanics and biomedical engineering 0 38812356
2020 Therapy-Related Acute Myeloid Leukemia Following TCHP Chemotherapy in Two HER2+ Breast Cancer Patients. Cureus 0 33425535