Affinage

AURKA

Aurora kinase A · UniProt O14965

Length
403 aa
Mass
45.8 kDa
Annotated
2026-04-28
100 papers in source corpus 25 papers cited in narrative 25 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

AURKA is a centrosome-associated serine/threonine kinase that governs centrosome maturation, mitotic spindle assembly, and cytokinesis, with additional non-mitotic roles in ciliary disassembly, spermatogenesis, and meiotic spindle organization (PMID:9771714, PMID:34518881, PMID:31895686). It is activated at the centrosome and spindle by structurally distinct cofactors — TPX2, CEP192 (via a dedicated helix binding a site separate from TPX2), Ca²⁺/calmodulin, and Bora — and phosphorylates PLK1 to trigger mitotic entry, HDM2 to promote p53 ubiquitination, SPOP to stabilize AR and c-Myc, and KEAP1 to activate NRF2-dependent ferroptosis suppression (PMID:37083534, PMID:22621899, PMID:26779436, PMID:24240108, PMID:33158056, PMID:38642502). AURKA protein levels are tightly controlled by degradative ubiquitination through APC/C-FZR1 and SMAD4-dependent proteasomal pathways, counterbalanced by stabilizing monoubiquitination from CBLC and deubiquitination by USP21 (PMID:30498084, PMID:25061104, PMID:35149839, PMID:36919585). A non-mitotic nuclear pool of AURKA, promoted by TPX2 co-expression and impaired proteasomal clearance, partners with hnRNP K in a kinase-independent manner to transactivate MYC and with DDX5 to induce lncRNA transcription (PMID:26782714, PMID:36797043, PMID:37217070).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1998 High

    The fundamental question of AURKA's cellular function was answered: it is a centrosomal kinase whose overexpression drives centrosome amplification, aneuploidy, and transformation, establishing it as a mitotic fidelity factor and proto-oncogene.

    Evidence Ectopic overexpression in NIH 3T3 and near-diploid breast epithelial cells with centrosome counting and transformation assays

    PMID:9771714

    Open questions at the time
    • Endogenous substrates not identified
    • Mechanism of centrosome amplification (direct vs. indirect) unclear
    • Loss-of-function phenotype not yet established
  2. 2012 High

    The question of how AURKA is activated at the basal body for ciliary disassembly was resolved: Ca²⁺/calmodulin binds AURKA directly, is required for its activation, and CaM-binding-deficient mutants fail in both ciliary resorption and mitotic progression.

    Evidence Biochemical CaM-binding assays, CaM-binding-site mutagenesis, live-cell imaging of cilia and mitosis, pharmacological CaM inhibition

    PMID:22621899

    Open questions at the time
    • Structural basis of CaM–AURKA interaction not determined
    • Relative contribution of CaM vs. TPX2 activation at different subcellular sites unresolved
  3. 2013 High

    Two studies extended AURKA's substrate repertoire and upstream regulation: AURKA directly phosphorylates HDM2 to promote p53 ubiquitination, and Bcr-Abl upregulates AURKA via AKT signaling in leukemia.

    Evidence In vitro kinase assay with recombinant AURKA/HDM2, Co-IP, ubiquitination assay (HDM2); shRNA AKT knockdown in Bcr-Abl-transduced CD34+ cells (AKT axis)

    PMID:23934627 PMID:24240108

    Open questions at the time
    • HDM2 phosphorylation site(s) not mapped
    • Whether AKT regulation of AURKA is transcriptional or post-translational not fully resolved
  4. 2014 High

    AURKA's signaling network was broadened to include phosphoinositide metabolism and Wnt/β-catenin suppression: AURKA phosphorylates INPP5E to enhance its phosphatase activity, and SMAD4 binds AURKA to drive its proteasomal degradation independently of TGFβ, repressing β-catenin/TCF transcription.

    Evidence In vitro kinase and phosphatase activity assays for INPP5E; Co-IP plus proteasome inhibitor rescue and β-catenin/TCF reporter for SMAD4–AURKA

    PMID:25061104 PMID:25395580

    Open questions at the time
    • Phosphorylation sites on INPP5E not mapped
    • E3 ligase mediating SMAD4-induced AURKA degradation not identified
    • SMAD4–AURKA interaction domain not mapped
  5. 2015 Medium

    The cofactor requirements for AURKA's key mitotic function — PLK1 activation at G2/M — were clarified: Bora is essential for AURKA-mediated PLK1 phosphorylation, working alongside TPX2 and CEP192 as spatially distinct activators.

    Evidence Literature synthesis of epistasis and phosphorylation assays from multiple labs

    PMID:26779436

    Open questions at the time
    • No new experimental data in this source
    • How Bora vs. TPX2 activation are spatially partitioned in vivo not resolved
  6. 2016 High

    A kinase-independent nuclear function of AURKA was discovered: nuclear AURKA interacts with hnRNP K to form a transcriptional complex that activates the MYC promoter, uncoupling AURKA's oncogenic action from its catalytic activity.

    Evidence Reciprocal Co-IP of nuclear AURKA with hnRNP K, kinase-dead mutant rescue, MYC promoter luciferase assay, breast cancer stem cell functional assays

    PMID:26782714

    Open questions at the time
    • How AURKA is recruited to chromatin at the MYC promoter not determined
    • Whether other promoters are co-regulated unknown
    • Nuclear import mechanism not defined
  7. 2018 High

    The degradation axis controlling AURKA levels was mechanistically extended: PRL-3 dephosphorylates FZR1 to activate APC/C-FZR1, which ubiquitinates and degrades AURKA, causing G2/M arrest.

    Evidence Co-IP, ubiquitination assay, phosphatase-dead PRL-3 mutant, AURKA ectopic rescue, xenograft validation

    PMID:30498084

    Open questions at the time
    • FZR1 phosphorylation site targeted by PRL-3 not mapped
    • Relative contribution of APC/C-FZR1 vs. other E3 ligases to AURKA turnover in normal cells not quantified
  8. 2020 High

    Multiple discoveries expanded AURKA's substrate portfolio and stability regulation: AURKA phosphorylates SPOP to trigger its degradation (stabilizing AR and c-Myc); ID1 competitively inhibits APC/C-Cdh1 to stabilize AURKA; and AURKA kinase activity organizes acentriolar MTOCs during oocyte meiosis.

    Evidence Direct in vitro kinase assay and phospho-resistant SPOP mutant with xenograft models; Co-IP of ID1 with APC/C-Cdh1 and half-life measurement; AURKA inhibitor treatment in mouse oocytes with super-resolution microscopy

    PMID:31895686 PMID:32705157 PMID:33158056

    Open questions at the time
    • SPOP phosphorylation sites' individual contributions not dissected
    • ID1–APC/C competition stoichiometry not quantified
    • How AURKA organizes CEP215 ring structures mechanistically unknown
  9. 2021 High

    Conditional knockout in mice established that AURKA has essential non-mitotic roles in spermatogenesis: loss in spermatogonia ablates germ cell development, while loss in spermatocytes causes morphological and motility defects linked to altered PP1 phosphatase activity.

    Evidence Conditional Aurka knockout (spermatogonia- and spermatocyte-specific Cre), histology, sperm analysis, PP1 activity assay

    PMID:34518881

    Open questions at the time
    • Direct AURKA substrates in germ cells not identified
    • Whether PP1 regulation is direct or indirect not determined
  10. 2022 High

    A non-degradative ubiquitination mechanism stabilizing AURKA was identified: CBLC conjugates mono- and K11/K63-linked polyubiquitin to AURKA, shielding it from K11/K48 degradative chains and promoting timely mitotic entry.

    Evidence IP/MS interactome, ubiquitin linkage mapping, cycloheximide chase, cell synchronization, xenograft models

    PMID:35149839

    Open questions at the time
    • Specific AURKA lysine residues modified by CBLC not mapped
    • How CBLC-mediated ubiquitination is temporally regulated during cell cycle not resolved
  11. 2023 High

    Multiple 2023 studies refined AURKA's structural activation, nuclear regulation, and novel substrates: CEP192 binds AURKA through a conserved helix at a site distinct from TPX2 (crystal structure solved); TPX2 promotes AURKA nuclear accumulation when proteasomal clearance is impaired; AURKA phosphorylates KEAP1 to activate NRF2 and suppress ferroptosis; USP21 deubiquitinates and stabilizes AURKA; and AURKA partners with DDX5 to drive lncRNA transcription.

    Evidence Crystal structure of CEP192 helix–AURKA complex with mitotic defect readout; fluorescence microscopy with TPX2 co-overexpression and proteasome inhibition; in vitro KEAP1 phosphorylation assay; GST pulldown and ubiquitination assay for USP21; Co-IP of AURKA–DDX5 with transcriptional and RNA pulldown assays

    PMID:36797043 PMID:36919585 PMID:37083534 PMID:37217070 PMID:38642502

    Open questions at the time
    • How CEP192 and TPX2 binding are coordinated at centrosomes in real time not known
    • Full NRF2-target gene set regulated through AURKA–KEAP1 not defined
    • AURKA–DDX5 transcriptional complex validated in only one cancer type

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions remain: the full catalog of AURKA substrates across mitotic versus non-mitotic contexts is incomplete; the structural basis and regulation of AURKA nuclear import are undefined; how the multiple E3 ligase and DUB inputs are integrated to set AURKA protein levels during the cell cycle has not been quantitatively modeled; and whether kinase-independent transcriptional functions are a general or tissue-restricted feature is unknown.
  • No systematic substrate screen across cell contexts
  • Nuclear import signal and importin specificity undefined
  • Quantitative integration of multiple ubiquitin-modifying enzymes not modeled

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 5 GO:0140110 transcription regulator activity 3
Localization
GO:0005634 nucleus 3 GO:0005815 microtubule organizing center 3 GO:0005929 cilium 3
Pathway
R-HSA-1640170 Cell Cycle 5 R-HSA-392499 Metabolism of proteins 4 R-HSA-162582 Signal Transduction 3 R-HSA-5357801 Programmed Cell Death 2
Partners
CALM1CBLCCEP192DDX5HNRNPKSPOPTPX2USP21
Complex memberships
AURKA/CEP192AURKA/TPX2AURKA/hnRNP K

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 STK15/BTAK/AURKA is a centrosome-associated serine/threonine kinase whose ectopic overexpression in NIH 3T3 and near-diploid human breast epithelial cells induces centrosome amplification, aneuploidy, and oncogenic transformation, establishing its role in maintaining genomic stability during mitosis. Ectopic overexpression in NIH 3T3 and breast epithelial cells; immunofluorescence for centrosome number; transformation assay in vitro Nature genetics High 9771714
2012 AURKA activation at the basal body during ciliary disassembly and in mitosis requires binding of Ca2+/calmodulin (CaM); CaM binding also promotes AURKA interaction with its activator NEDD9, and AURKA mutants impaired for CaM binding exhibit defects in mitotic progression, cytokinesis, and ciliary resorption. Biochemical binding assays, site-directed mutagenesis of CaM-binding residues, live-cell imaging, pharmacological CaM inhibition, functional rescue experiments Molecular biology of the cell High 22621899
2014 INPP5E interacts directly with AURKA; AURKA phosphorylates INPP5E to increase its 5-phosphatase activity, which in turn promotes transcriptional downregulation of AURKA partly through an AKT-dependent mechanism, linking AURKA to phosphoinositide signaling and primary cilium stability. Co-immunoprecipitation, in vitro kinase assay, phosphatase activity assay, siRNA knockdown, luciferase reporter assay Journal of cell science High 25395580
2016 AURKA translocates to the nucleus and, independent of its kinase activity, interacts with hnRNP K to form a transcriptional complex that activates the MYC promoter and enhances breast cancer stem cell phenotype; blocking AURKA nuclear localization abolishes this transactivating function and sensitizes resistant cells to kinase inhibition. Co-immunoprecipitation of nuclear AURKA with hnRNP K, kinase-dead AURKA mutant, MYC promoter luciferase assay, nuclear localization inhibition, BCSC functional assays Nature communications High 26782714
2013 AURKA directly interacts with and phosphorylates HDM2 (MDM2) in vitro, leading to P53 ubiquitination and suppression of cisplatin-induced P53 apoptotic activation in gastric cancer cells. Dual co-immunoprecipitation, in vitro kinase assay with recombinant AURKA and HDM2, ubiquitination assay, AURKA overexpression/knockdown cell models Clinical cancer research High 24240108
2015 Bora serves as an essential cofactor enabling AURKA to phosphorylate and activate the mitotic kinase PLK1 (polo-like kinase 1) at the G2/M transition; AURKA and PLK1 engage in reciprocal regulation throughout mitosis involving multiple interactors including TPX2 and CEP192. Literature synthesis of epistasis, phosphorylation assays, and interaction studies reviewed from primary literature Frontiers in oncology Medium 26779436
2013 Bcr-Abl induces expression of AURKA (and AURKB) in chronic myeloid leukemia cells at least in part via AKT signaling; shRNA knockdown of AKT in Bcr-Abl-transduced CD34+ HSPCs decreases AURKA levels. Lentiviral transduction of Bcr-Abl, shRNA knockdown of AKT, Western blot for AURKA/AURKB, colony forming assay, xenograft engraftment International journal of cancer Medium 23934627
2014 AURKA regulates STAT3 transcriptional activity through the JAK2 axis in gastric and esophageal cancer cells; AURKA overexpression increases STAT3 phosphorylation at Tyr705 and nuclear translocation, and JAK2 inhibition or knockdown abrogates AURKA-mediated STAT3 activation. AURKA overexpression/siRNA knockdown, immunofluorescence for STAT3 nuclear translocation, luciferase STAT3 reporter, JAK2-specific inhibitor and siRNA epistasis Molecular oncology Medium 24953013
2018 PRL-3 phosphatase dephosphorylates FZR1, activating the APC/C-FZR1 complex, which then ubiquitinates AURKA and promotes its degradation; this PRL-3-mediated destabilization of AURKA drives G2-M arrest and chromosomal instability in colorectal cancer. Co-immunoprecipitation of PRL-3 with AURKA and FZR1, ubiquitination assay, phosphatase-dead PRL-3 mutant, AURKA ectopic expression rescue, xenograft models Cancer research High 30498084
2014 SMAD4 binds directly to AURKA and induces its proteasomal degradation in a TGFβ-independent manner, thereby suppressing AURKA-mediated β-catenin/TCF transcriptional activity and metastatic phenotypes. Co-immunoprecipitation of SMAD4 with AURKA, proteasome inhibitor rescue, luciferase β-catenin/TCF reporter, AURKA overexpression/silencing rescue, TGFβ receptor blockade Molecular cancer research Medium 25061104
2020 AURKA directly phosphorylates SPOP at three sites, causing its ubiquitylation and degradation; SPOP in turn degrades AURKA via a feedback loop; AURKA-mediated SPOP degradation stabilizes AR, ARv7, and c-Myc to drive castration-resistant prostate cancer progression. Innovative direct substrate identification assay, in vitro phosphorylation assay, phospho-resistant SPOP mutant, ubiquitination assay, xenograft in vivo models Cancers High 33158056
2022 CBLC (an E3 ubiquitin ligase) interacts with the kinase domain of AURKA and stabilizes it by conjugating monoubiquitination and K11/K63-linked polyubiquitination that protect AURKA from degrading K11/K48 polyubiquitination; CBLC depletion delays AURKA accumulation and mitotic entry. Immunoprecipitation/mass spectrometry of CBLC interactome, co-IP, cycloheximide chase, cell synchronization experiments, xenograft models Oncogene High 35149839
2023 USP21 deubiquitinase directly interacts with AURKA (confirmed by Co-IP and GST pulldown), deubiquitinates AURKA to reduce its ubiquitination level and restore AURKA activity and stability, thereby promoting laryngeal cancer cell proliferation, migration, and invasion. Co-immunoprecipitation, GST pulldown, ubiquitination assay, siRNA knockdown, AURKA rescue experiments The Kaohsiung journal of medical sciences Medium 36919585
2023 CEP192 contains a conserved helix (Helix-1) that binds AURKA at a site distinct from the TPX2 binding site; crystal structure of Helix-1 bound to AURKA was solved, and disruption of this interaction in cells causes mitotic defects, demonstrating CEP192 as a distinct structural regulator of centrosomal AURKA. Crystal structure determination, quantitative binding studies, cell-based disruption of CEP192-AURKA interaction with mitotic defect readout Science advances High 37083534
2019 CEP41-mediated tubulin glutamylation of cilia activates AURKA and upregulates VEGFA/VEGFR2 expression to promote deciliation and angiogenesis; AURKA is downstream of CEP41/HIF1α in this axis and upstream of VEGF during hypoxia-induced angiogenesis. siRNA/CRISPR knockdown in human endothelial cells and zebrafish models, AURKA activity assays, VEGF pathway readouts, ciliary disassembly quantification EMBO reports Medium 31885126
2023 AURKA binds directly to DDX5 to form a transcriptional coactivator complex that induces transcription of the lncRNA TMEM147-AS1, creating a feedback loop (TMEM147-AS1 sponges let-7 miRNA to increase AURKA expression) that maintains cisplatin resistance via lipophagy activation in epithelial ovarian cancer. Co-immunoprecipitation of AURKA-DDX5, RNA pulldown, transcriptional assays, luciferase reporter for let-7/AURKA axis, lipophagy assays Cancer letters Medium 37217070
2023 AURKA directly interacts with and phosphorylates KEAP1, thereby activating NRF2 and its target gene transcription to suppress erastin-induced ferroptosis in meningioma; FOXM1 facilitates AURKA transcription upstream. Co-immunoprecipitation of AURKA with KEAP1, in vitro phosphorylation assay, NRF2 target gene reporter assays, pharmacological AURKA inhibition combined with ferroptosis induction in murine model Redox biology Medium 38642502
2020 AURKA inhibition (using alisertib) in AML cells accelerates expression of the H3K27 demethylase KDM6B by dissociating AURKA and YY1 from the KDM6B promoter region, thereby promoting monocytic differentiation of THP-1 leukemia cells; H3S10 phosphorylation is reduced upon AURKA loss. ChIP showing AURKA and YY1 occupancy at KDM6B promoter, alisertib treatment, flow cytometry for differentiation markers, pharmacological KDM6B inhibition epistasis Molecules and cells Medium 29477140
2023 AURKA nuclear localization is promoted by TPX2 co-overexpression and counteracted by proteasome-mediated protein degradation; nuclear AurkA accumulation in interphase requires both TPX2 and impaired proteasome activity, and nuclear AurkA drives protumorigenic processes in mammospheres. Fluorescence microscopy of AURKA localization in cell cycle phases, nuclear export inhibition, co-overexpression of TPX2, proteasome inhibitor treatment, MCF10A mammosphere functional assays Life science alliance Medium 36797043
2021 Conditional knockout of Aurka in mouse spermatogonia results in complete loss of all developing germ cells; knockout in spermatocytes reduces sperm count, increases apoptosis, causes abnormal sperm morphology, and elevates progressive motility with decreased PP1 phosphatase activity in sperm lysate, demonstrating nonmitotic roles of AURKA in spermatogenesis. Conditional knockout mouse models (spermatogonia-specific and spermatocyte-specific Cre), testis histology, sperm motility analysis, PP1 activity assay in sperm lysate Biology of reproduction High 34518881
2020 In mouse oocytes, AURKA kinase activity is required for the ring-like structural organization of acentriolar MTOCs (aMTOCs) and for proper spindle pole focusing during meiosis; AURKA inhibition causes loss of CEP215 ring-like organization and CEP215 clustering at spindle poles with shorter, highly focused spindles. AURKA kinase inhibitor treatment in MI and MII oocytes, super-resolution microscopy, siRNA-mediated CEP215 knockdown, fluorescence quantification at aMTOCs Reproduction Medium 31895686
2023 CD73/NT5E directly interacts with AURKA (confirmed by Co-IP and molecular docking), and CD73/NT5E overexpression inhibits AURKA ubiquitination, stabilizing AURKA and suppressing p53 signaling to regulate hepatic stellate cell activation and senescence in alcohol-related liver fibrosis. Co-immunoprecipitation, molecular docking, ubiquitination assay, mouse ALF model with CD73/NT5E knockout International journal of biological sciences Medium 36778123
2015 LIN28B promotes RAN expression (by binding RAN mRNA and promoting RANBP2 expression), and LIN28B and RAN signaling converge on AURKA kinase activity to drive neuroblastoma oncogenesis. RNA immunoprecipitation (LIN28B binding RAN mRNA), genetic epistasis via RAN overexpression/knockdown, AURKA activity assays, neuroblastoma cell and mouse models Cancer cell Medium 26481147
2024 The AurkA/TPX2 interaction is a critical oncogenic unit; TPX2 controls AurkA activation, localization, and stabilization, and AurkA/TPX2 co-overexpression drives chromosomal instability and cancer through coordinated mitotic phenotypes distinct from overexpression of either alone. Review of literature including biochemical interaction studies, overexpression phenotypic analyses, and therapeutic disruption of AurkA/TPX2 complex Cells Medium 39195284
2020 ID1 competitively binds APC/C-Cdh1 to prevent it from ubiquitinating AURKA, thereby stabilizing AURKA protein; elevated AURKA then enhances c-Myc expression at both transcriptional and post-transcriptional levels to amplify oncogenic signaling in hepatocellular carcinoma. Co-immunoprecipitation of ID1 with APC/C-Cdh1, AURKA protein half-life measurement, AURKA inhibitor and Myc inhibitor rescue experiments International journal of oncology Medium 32705157

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nature genetics 1115 9771714
2021 Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy. Molecular cancer 402 33451333
2010 Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. The Journal of neuroscience : the official journal of the Society for Neuroscience 324 20592202
2003 Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 296 12631597
2003 Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 268 12684414
2001 Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. Proceedings of the National Academy of Sciences of the United States of America 212 11331748
2001 Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers. International journal of cancer 209 11291073
2013 Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer. Neoplasia (New York, N.Y.) 207 23358695
1995 Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1. The Journal of biological chemistry 205 7559596
2001 Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. British journal of cancer 194 11259099
2016 Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nature communications 158 26782714
2012 Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis. Molecular biology of the cell 132 22621899
2011 TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression. Gut 117 22207630
2005 The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 108 15756006
2003 The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton. EMBO reports 97 12634840
2019 Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers. Scientific reports 96 31740746
2015 A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis. Cancer cell 95 26481147
2015 Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly. Frontiers in oncology 81 26779436
2014 INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability. Journal of cell science 71 25395580
2016 Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression. Oncotarget 68 27329586
2018 Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. Nature chemical biology 67 29942081
2014 AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. Molecular oncology 67 24953013
2012 Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer. Cancer research 67 23204235
2004 Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells. International journal of oncology 64 15547700
2015 Tanshinones suppress AURKA through up-regulation of miR-32 expression in non-small cell lung cancer. Oncotarget 63 26036635
2013 HDM2 regulation by AURKA promotes cell survival in gastric cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 60 24240108
2003 Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 60 14693746
1996 Mitochondrial DNA in migraine with aura. Neurology 60 8649580
2005 Breast cancer risk associated with genotypic polymorphism of the mitosis-regulating gene Aurora-A/STK15/BTAK. International journal of cancer 56 15688402
2007 The suppression of aurora-A/STK15/BTAK expression enhances chemosensitivity to docetaxel in human esophageal squamous cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 53 17317845
2007 Familial occipitotemporal lobe epilepsy and migraine with visual aura: linkage to chromosome 9q. Neurology 53 17460155
2011 Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2. Journal of cell science 49 21540296
2017 The expression of AURKA is androgen regulated in castration-resistant prostate cancer. Scientific reports 47 29269934
2014 AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment. Journal of translational medicine 46 25074438
2005 Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer. Oncology research 44 15839305
2018 Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer. Scientific reports 43 29760449
2017 miR-124 suppresses glioblastoma growth and potentiates chemosensitivity by inhibiting AURKA. Biochemical and biophysical research communications 43 28242198
2005 AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells. Cancer genetics and cytogenetics 42 15860351
2005 Amplification and overexpression of aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells. Molecular carcinogenesis 42 15880741
2021 Tanshinone IIA suppresses the progression of lung adenocarcinoma through regulating CCNA2-CDK2 complex and AURKA/PLK1 pathway. Scientific reports 38 34880385
2004 Mitosis: MCAK under the aura of Aurora B. Current biology : CB 38 15120087
2018 Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma. Neoplasia (New York, N.Y.) 37 30153557
2022 A Temporal PROTAC Cocktail-Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 35 35652200
2021 ARID3A promotes the development of colorectal cancer by upregulating AURKA. Carcinogenesis 35 33165575
2018 Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma. International journal of medical sciences 35 29333101
2018 PRL-3 Promotes Ubiquitination and Degradation of AURKA and Colorectal Cancer Progression via Dephosphorylation of FZR1. Cancer research 35 30498084
2020 Genetics of migraine aura: an update. The journal of headache and pain 34 32503413
2021 The long-noncoding RNA SOCS2-AS1 suppresses endometrial cancer progression by regulating AURKA degradation. Cell death & disease 33 33824269
2013 Bcr-Abl activates AURKA and AURKB in chronic myeloid leukemia cells via AKT signaling. International journal of cancer 33 23934627
2007 An adenosine A2A receptor gene haplotype is associated with migraine with aura. Cephalalgia : an international journal of headache 33 17257240
2019 Migraine Aura: Pathophysiology, Mimics, and Treatment Options. Seminars in neurology 31 31847045
2019 CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation. EMBO reports 30 31885126
2022 CCNB1 and AURKA are critical genes for prostate cancer progression and castration-resistant prostate cancer resistant to vinblastine. Frontiers in endocrinology 27 36601001
2020 Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA. Biochemical pharmacology 27 32224138
2020 PUF60/AURKA Axis Contributes to Tumor Progression and Malignant Phenotypes in Bladder Cancer. Frontiers in oncology 26 33117697
2023 Calcitonin gene-related peptide causes migraine aura. The journal of headache and pain 25 37679723
2019 Linc00299/miR-490-3p/AURKA axis regulates cell growth and migration in atherosclerosis. Heart and vessels 25 30734057
2014 Calcitonin gene-related peptide and migraine with aura: A systematic review. Cephalalgia : an international journal of headache 25 24452423
2024 Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis. Redox biology 24 38642502
2023 HMMR promotes prostate cancer proliferation and metastasis via AURKA/mTORC2/E2F1 positive feedback loop. Cell death discovery 24 36750558
2021 Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal Cancer. Cellular and molecular gastroenterology and hepatology 24 34700030
1998 Mitochondrial DNA in stroke and migraine with aura. Cerebrovascular diseases (Basel, Switzerland) 24 9548008
2021 LINC00958 promotes bladder cancer carcinogenesis by targeting miR-490-3p and AURKA. BMC cancer 23 34702201
2021 Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress. Cellular oncology (Dordrecht, Netherlands) 21 34176092
2023 The feedback loop of AURKA/DDX5/TMEM147-AS1/let-7 drives lipophagy to induce cisplatin resistance in epithelial ovarian cancer. Cancer letters 20 37217070
2023 Abnormal Glutamatergic and Serotonergic Connectivity in Visual Snow Syndrome and Migraine with Aura. Annals of neurology 20 37466404
2022 Induction of Ferroptosis by Ophiopogonin-B Through Regulating the Gene Signature AURKA in NSCLC. Frontiers in oncology 20 35875069
2019 MiR-26a-5p Inhibits Cell Proliferation and Enhances Doxorubicin Sensitivity in HCC Cells via Targeting AURKA. Technology in cancer research & treatment 20 31570091
2017 EGFR T790M mutation testing within the osimertinib AURA Phase I study. Lung cancer (Amsterdam, Netherlands) 20 28577957
2024 AURKA inhibition induces Ewing's sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis. Cell death & disease 19 38287009
2020 Molecular Interplay between AURKA and SPOP Dictates CRPC Pathogenesis via Androgen Receptor. Cancers 19 33158056
2020 CEP215 and AURKA regulate spindle pole focusing and aMTOC organization in mouse oocytes. Reproduction (Cambridge, England) 18 31895686
2018 The Association Between AURKA Gene rs2273535 Polymorphism and Gastric Cancer Risk in a Chinese Population. Frontiers in physiology 18 30174615
1999 Chromosome 6p-encoded HLA-DR2 determination discriminates migraine without aura from migraine with aura. Human immunology 18 9952029
2024 Contribution of AurkA/TPX2 Overexpression to Chromosomal Imbalances and Cancer. Cells 17 39195284
2023 Structural basis for CEP192-mediated regulation of centrosomal AURKA. Science advances 17 37083534
2022 Long noncoding RNA ELDR promotes cell cycle progression in normal oral keratinocytes through induction of a CTCF-FOXM1-AURKA signaling axis. The Journal of biological chemistry 17 35378133
2020 Dual-Inhibitors of N-Myc and AURKA as Potential Therapy for Neuroendocrine Prostate Cancer. International journal of molecular sciences 17 33167327
2016 Association of the AURKA and AURKC gene polymorphisms with an increased risk of gastric cancer. IUBMB life 17 27270838
2014 SMAD4 suppresses AURKA-induced metastatic phenotypes via degradation of AURKA in a TGFβ-independent manner. Molecular cancer research : MCR 17 25061104
2023 The promotion action of AURKA on post-ischemic angiogenesis in diabetes-related limb ischemia. Molecular medicine (Cambridge, Mass.) 16 36977984
2023 LncRNA TIALD contributes to hepatocellular carcinoma metastasis via inducing AURKA lysosomal degradation. Cell death discovery 16 37773181
2018 AURKA Suppresses Leukemic THP-1 Cell Differentiation through Inhibition of the KDM6B Pathway. Molecules and cells 16 29477140
2003 Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1. American journal of physiology. Heart and circulatory physiology 16 12869383
2022 Stabilization of AURKA by the E3 ubiquitin ligase CBLC in lung adenocarcinoma. Oncogene 15 35149839
2021 Knockdown of AURKA sensitizes the efficacy of radiation in human colorectal cancer. Life sciences 15 33545203
2019 Comparing migraine with and without aura to healthy controls using RNA sequencing. Cephalalgia : an international journal of headache 15 31104508
2018 Gossypin inhibits gastric cancer growth by direct targeting of AURKA and RSK2. Phytotherapy research : PTR 15 30536456
2017 Recognizing CADASIL: a Secondary Cause of Migraine with Aura. Current pain and headache reports 15 28281108
2023 AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation. Life science alliance 14 36797043
2023 USP21 contributes to the aggressiveness of laryngeal cancer cells by deubiquitinating and stabilizing AURKA. The Kaohsiung journal of medical sciences 14 36919585
2023 E2F1-mediated KDM4A-AS1 up-regulation promotes EMT of hepatocellular carcinoma cells by recruiting ILF3 to stabilize AURKA mRNA. Cancer gene therapy 14 36973424
2023 CD73/NT5E-mediated ubiquitination of AURKA regulates alcohol-related liver fibrosis via modulating hepatic stellate cell senescence. International journal of biological sciences 13 36778123
2023 STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer. Journal of translational medicine 13 37101292
2021 Aurora A Kinase (AURKA) is required for male germline maintenance and regulates sperm motility in the mouse. Biology of reproduction 13 34518881
2020 ID1 overexpression promotes HCC progression by amplifying the AURKA/Myc signaling pathway. International journal of oncology 13 32705157
2017 Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. Molecular cancer research : MCR 13 28442587
2017 Inhibition of AURKA kinase activity suppresses collective invasion in a microfluidic cell culture platform. Scientific reports 13 28592839
2008 AURKA overexpression accompanies dysregulation of DNA-damage response genes in invasive urothelial cell carcinoma. Cell cycle (Georgetown, Tex.) 13 19001879
2007 Activation of BTAK expression in primary ovarian surface epithelial cells of prophylactic ovaries. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 13 17673924