Affinage

NUP54

Nucleoporin p54 · UniProt Q7Z3B4

Round 2 corrected
Length
507 aa
Mass
55.4 kDa
Annotated
2026-04-29
62 papers in source corpus 19 papers cited in narrative 19 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NUP54 is a central channel nucleoporin that functions as the core scaffold of the NUP62–NUP54–NUP58 complex, directly binding both partners through conserved coiled-coil domains to form the principal permeability barrier and transport conduit of the nuclear pore complex (PMID:2050741, PMID:24574455, PMID:26025361). The complex selectively facilitates importin-α/β-dependent nuclear import, provides progressively higher-affinity binding sites for importin-β that support directional cargo translocation, and undergoes allosteric conformational changes coupled to transport factor occupancy that gate the central channel between constricted and dilated states (PMID:11266456, PMID:17682050, PMID:26046439, PMID:33346731). Beyond canonical transport, NUP54 participates in homologous recombination repair of DNA double-strand breaks in epistasis with RAD51, recruits PLK-1 via phosphorylation-primed Polo-box docking to drive nuclear envelope breakdown in mitosis, and has tissue-specific roles in piRNA biogenesis and neuronal wiring (PMID:29986057, PMID:29065307, PMID:33856346, PMID:34666772). Biallelic pathogenic variants in the NUP62-binding C-terminal domain of NUP54 cause early-onset dystonia with striatal degeneration (PMID:36333996).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1991 High

    Establishing that NUP54 is an essential subunit of a trimeric nucleoporin complex required for nuclear transport resolved the question of which NPC components constitute the functional transport machinery.

    Evidence Co-immunoprecipitation, depletion-reconstitution nuclear transport assay in Xenopus extracts

    PMID:2050741

    Open questions at the time
    • Stoichiometry and direct contacts within the complex were undefined
    • Which specific transport pathway(s) the complex serves was unknown
  2. 1994 High

    Demonstrating that the NUP62–NUP54–NUP58 complex resides in the central channel of the NPC localized its function to the gated transport conduit rather than peripheral scaffolding structures.

    Evidence Detergent/salt extraction, immunogold EM, in vitro galactosylation assay

    PMID:8045926

    Open questions at the time
    • Precise arrangement of subunits within the channel was unknown
    • Whether the complex undergoes conformational changes during transport was untested
  3. 2001 Medium

    Quantitative binding studies revealed that the NUP62 complex provides a higher-affinity importin-β binding site than cytoplasmic NUP358, supporting a gradient model for directional cargo translocation through the NPC.

    Evidence Solid-phase binding assay with purified nucleoporins, antibody inhibition of nuclear import

    PMID:11266456

    Open questions at the time
    • Gradient model not tested with competing nucleoporins in an intact pore context
    • Affinity measurements were in vitro and may not reflect in vivo occupancy
  4. 2007 High

    Systematic RNAi screening showed NUP54 is selectively required for importin-α/β-mediated import but dispensable for CRM1-dependent export, establishing pathway specificity for the central channel complex.

    Evidence RNAi knockdown of 30 nucleoporins in Drosophila S2 cells with pathway-specific transport reporters

    PMID:17682050

    Open questions at the time
    • Mechanism of selectivity for importin-α/β over CRM1 pathway was not resolved
    • Applicability to mammalian cells not directly tested in this study
  5. 2014 High

    Reconstitution and hydrodynamic analysis established the 1:1:1 stoichiometry of the complex with NUP54 as the central scaffold bridging NUP62 and NUP58, answering how the subunits are arranged.

    Evidence Gel filtration, analytical ultracentrifugation, in vitro reconstitution of human and yeast complexes

    PMID:24574455

    Open questions at the time
    • Crystal structures of the full trimeric assembly were not yet available
    • Whether stoichiometry changes in situ within the NPC was unknown
  6. 2015 High

    Crystal structures and equilibrium analyses revealed that NUP54's disordered FG domains and NUP58's structured domains are allosterically coupled, with importin-β binding shifting oligomeric equilibria to provide a mechanism for transport-dependent channel gating.

    Evidence X-ray crystallography, quantitative multi-equilibrium analysis, mutagenesis; complementary structures of Nup54·Nup58 and Nup54·Nup62 subcomplexes

    PMID:26025361 PMID:26046439

    Open questions at the time
    • Ring-cycle dilation/constriction model awaits validation in intact NPCs
    • Whether allosteric coupling operates on biologically relevant timescales in vivo was untested
  7. 2017 High

    Multiple studies converged to reveal NUP54's FG domain forms labile cross-β polymers that are disrupted by C9orf72 poly-dipeptides, its coiled-coil domain enables heterotrimeric chain exchange with NUP62, and the NPC-localized complex recruits PLK-1 for mitotic nuclear envelope breakdown — expanding NUP54's roles beyond steady-state transport.

    Evidence Chemical footprinting and mutagenesis of FG polymers; X-ray crystallography of NUP62 coiled-coil with SEC-MALS; Co-IP, genetic rescue, and live imaging of PLK-1 recruitment in C. elegans and human cells

    PMID:28069952 PMID:28406021 PMID:29065307

    Open questions at the time
    • Whether cross-β polymers form in vivo within the NPC channel was not demonstrated
    • Structural basis for PLK-1 docking on NUP54 versus NUP62/NUP58 was not resolved
  8. 2018 High

    Demonstrating that NUP54 depletion impairs homologous recombination repair in epistasis with RAD51 established a transport-independent nuclear function for the central channel complex in genome maintenance.

    Evidence siRNA knockdown, HR reporter assay, epistasis with RAD51, sister chromatid exchange scoring, cell cycle analysis

    PMID:29986057

    Open questions at the time
    • Whether NUP54 acts at DSB sites or through nuclear import of repair factors was not distinguished
    • Structural basis for the NUP54–RAD51 epistatic relationship is unknown
  9. 2020 Medium

    In vivo FRET sensors directly demonstrated that NUP54, NUP58, and NUP62 undergo conformational changes during active transport, validating the allosteric gating model in living cells.

    Evidence Live-cell FRET imaging with rigidly conjugated mEGFP sensors under transport perturbation

    PMID:33346731

    Open questions at the time
    • FRET ensemble measurement does not resolve individual pore dynamics
    • Amplitude and kinetics of conformational change were not correlated with single-cargo transit events
  10. 2021 High

    Tissue-specific roles for NUP54 beyond bulk transport were established: NUP54 is required for piRNA biogenesis from the flamenco locus in Drosophila ovaries and for correct neuronal wiring underlying reproductive behavior, revealing specialized gene-regulatory functions.

    Evidence RNAi in Drosophila ovaries with small RNA sequencing; genetic mutagenesis with behavioral and neuroanatomical analysis

    PMID:33856346 PMID:34666772

    Open questions at the time
    • Mechanism by which NUP54 specifically licenses flamenco piRNA production is unknown
    • Whether neuronal wiring defects reflect altered transport of specific cargoes or chromatin-level effects is unresolved
  11. 2022 Medium

    Pathogenic biallelic NUP54 variants disrupting the NUP62-binding C-terminal domain were identified as causal for early-onset dystonia with striatal degeneration, and mitotic dissolution of the complex by TIP60-mediated acetylation of NUP62 was characterized, linking post-translational regulation of complex integrity to cell division.

    Evidence Patient exome sequencing with biochemical validation of impaired NUP54–NUP62 interaction; mass spectrometry identification of NUP62 K432 acetylation with mutagenesis and live-cell imaging

    PMID:36190325 PMID:36333996

    Open questions at the time
    • Neuronal cell-type vulnerability mechanism in dystonia is unexplained
    • Whether NUP54 itself is a direct acetylation or phosphorylation target regulating complex dissolution is unknown
  12. 2024 Medium

    NUP54 was placed in the piRNA pathway in C. elegans by showing its orthologue promotes perinuclear localization of the Argonaute CSR-1, extending the piRNA connection across phyla.

    Evidence Sensitized piRNA reporter screen, fluorescence localization assay, RNAi in C. elegans

    PMID:37210214

    Open questions at the time
    • Whether NUP54 directly binds CSR-1 or acts indirectly through pore permeability is unknown
    • Conservation of this piRNA role in vertebrates is untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include how NUP54 distinguishes between importin-α/β and other transport receptors at the molecular level, whether its roles in HR repair and piRNA biogenesis are mechanistically linked to cargo selectivity or reflect transport-independent chromatin-proximal functions, and the structural basis for tissue-specific vulnerability in NUP54-associated dystonia.
  • No high-resolution structure of intact NUP62–NUP54–NUP58 complex within the NPC
  • Transport-independent versus transport-dependent mechanisms in HR repair are not distinguished
  • Neuronal cell-type specificity of NUP54 dystonia is mechanistically unexplained

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 5 GO:0005215 transporter activity 4
Localization
GO:0005635 nuclear envelope 4
Pathway
R-HSA-9609507 Protein localization 5 R-HSA-1640170 Cell Cycle 2 R-HSA-73894 DNA Repair 1
Partners
CARM1KPNB1NUP58NUP62PLK1RAD51
Complex memberships
NUP62–NUP54–NUP58 complex (Nup62 complex)

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1991 Nup54 (p54) forms a stable complex with p62 and p58 (Nup62 and Nup58) that is essential for nuclear pore function; depletion of this complex from nuclear reconstitution extracts abolishes nuclear transport, with a strict linear correlation between complex abundance and transport capacity. Co-immunoprecipitation, nuclear reconstitution depletion assay, gel filtration, nuclear transport assay The Journal of cell biology High 2050741
1994 The p62–p58–p54 complex (Nup62/Nup58/Nup54) is released from the NPC as a discrete high-molecular-weight complex; p54 and p58 are not galactosylated in vitro, localizing this complex to the central channel region. Co-immunoprecipitation, detergent/high-salt extraction, in vitro galactosylation assay, immunogold electron microscopy The Journal of cell biology High 8045926
2001 The Nup62 complex (containing Nup54) in the central channel of the NPC provides a progressively higher-affinity binding site for importin-β cargo complexes relative to cytoplasmic Nup358, supporting a directional gradient model for nuclear import. Quantitative solid-phase binding assay, antibody inhibition of nuclear import The Journal of cell biology Medium 11266456
2007 In Drosophila, RNAi knockdown of the Nup54 fly homologue (but not most other FG nucleoporins) selectively impairs importin-α/β-mediated nuclear import without affecting CRM1-dependent export, demonstrating a selective role for Nup54 in the import pathway. RNA interference in Drosophila S2 cells, nuclear import/export assays The Journal of cell biology High 17682050
2014 The Nup62 complex (Nup62:Nup54:Nup58) exists in solution at a 1:1:1 stoichiometry, with Nup54 central and directly binding both Nup62 and Nup58 via conserved coiled-coil segments; at high concentrations the complex forms larger assemblies while maintaining this ratio. The same stoichiometry is conserved in the yeast Nsp1 complex. Gel filtration, analytical ultracentrifugation, in vitro reconstitution Molecular biology of the cell High 24574455
2015 The structured domain of Nup58 and the disordered FG domain of Nup54 are allosterically coupled: multivalent binding of importin-β Kapβ1 to the disordered domains of Nup58 stabilizes a neighboring structured domain associated with Nup54, shifting equilibria from homo-oligomers to hetero-oligomers, providing a quantitative framework for central channel constriction and dilation as a function of transport factor occupancy. Analysis of multiple equilibria (quantitative binding), crystallography, mutagenesis Cell High 26046439
2015 The ordered regions of Nup62, Nup54, and Nup58 form a dynamic triple complex in solution built from two sub-interactomes: a Nup54·Nup58 interaction and a Nup54·Nup62 triple helix ('finger'); crystal structure-deduced copy numbers suggest a 4:2:1 (Nup62:Nup54:Nup58) stoichiometry supporting a ring-cycle model for NPC channel dilation and constriction. Size-exclusion chromatography, analytical ultracentrifugation, X-ray crystallography The Journal of biological chemistry High 26025361
2017 The FG domain of human Nup54 forms labile cross-β polymers detectable by chemical footprinting; mutations within the footprinted region block both polymerization and binding by the toxic PRn poly-dipeptide encoded by the C9orf72 repeat expansion, and 1,6-hexanediol melts these polymers in vitro, reversing PRn-mediated enhancement of nuclear pore permeability. Chemical footprinting, site-directed mutagenesis, in vitro polymerization assay, 1,6-hexanediol treatment Proceedings of the National Academy of Sciences of the United States of America High 28069952
2017 In C. elegans, the Nup54 orthologue NPP-4 (along with NPP-1/Nup58 and NPP-11/Nup62) recruits PLK-1 to the nuclear pore complex via physical interaction with PLK-1's Polo-box domain, primed by Cdk1 and PLK-1 phosphorylation at multiple Polo-docking sites; this NPC-based recruitment is required for efficient nuclear envelope breakdown. Co-immunoprecipitation, genetic rescue, live-cell imaging, RNAi knockdown, phosphorylation site mapping Developmental cell High 29065307
2017 Overexpression of NUP54 (along with NUP62) rescues the nuclear import defect of a TDP-43 NLS reporter caused by cytoplasmic poly-GA aggregates in C9orf72 ALS/FTLD, indicating that Nup54 functions in the importin-α/β-dependent nuclear import pathway. Fluorescence reporter rescue assay, overexpression in cell culture Human molecular genetics Medium 28040728
2017 The crystal structure of the Nup62 coiled-coil fragment reveals a parallel three-helix bundle that can form both homodimers/homotrimers and heterotrimers with Nup54 coiled-coil domain; comparative structural analysis demonstrates plasticity of the Nup62 coiled-coil enabling chain replacement to form diverse NPC assemblies. X-ray crystallography (2.4 Å), SEC-MALS, glutaraldehyde crosslinking Biochemistry High 28406021
2018 Nup54 (with its partners Nup62 and Nup58) is required for homologous recombination (HR) repair of DNA double-strand breaks: Nup54 depletion epistasizes with Rad51 deficiency, decreases HR reporter activity, reduces HR-linked DNA synthesis foci and sister chromatid exchanges after ionizing radiation, and causes mitotic catastrophe and G2 arrest specifically in cells with replicated DNA. siRNA knockdown, HR reporter assay, epistasis analysis with Rad51, FACS cell-cycle analysis, chromosome aberration scoring Nucleic acids research High 29986057
2020 In vivo FRET-based sensors show that the inner-ring nucleoporins Nup54, Nup58, and Nup62 undergo conformational changes when nucleocytoplasmic transport is perturbed, while Nups elsewhere in the NPC do not, indicating that the central channel undergoes dynamic conformational remodeling coupled to transport activity. Live-cell FRET imaging with rigidly conjugated mEGFP sensors, transport perturbation eLife Medium 33346731
2021 In Drosophila ovarian follicle cells, Nup54 and Nup58 are specifically required for piRNA biogenesis from the flamenco locus; loss of Nup54 or Nup58 compromises flamenco-dependent piRNA production without broadly disrupting nuclear transport, demonstrating a tissue-specific and locus-specific role for these channel nucleoporins in the piRNA pathway. RNAi knockdown in Drosophila ovaries, small RNA sequencing, genetic analysis eLife High 33856346
2021 Nup54 promotes CARM1 nuclear import in gastric cancer cells; once in the nucleus, CARM1 cooperates with TFEB to activate Notch2 transcription via H3R17me2 at the Notch2 promoter, and methylates N2ICD at R1786, R1838, and R2047, enhancing MAML1 binding and driving cell proliferation and tumor formation. Co-immunoprecipitation, nuclear fractionation, overexpression/knockdown, methylation assays, reporter assays, in vivo tumor xenograft Oncogene Medium 34725461
2021 In Drosophila, Nup54 is required for correct wiring of eight adult brain neurons expressing pickpocket that mediate egg-laying, and viable Nup54 mutants prevent the sex-peptide-induced post-mating response including egg-laying and reduced receptivity; the Nup54 promoter is a hotspot for rapid evolution and promoter variants alter nucleo-cytoplasmic shuttling. Genetic mutagenesis screen, behavioral assays, neuroanatomical analysis, promoter reporter assay BMC biology Medium 34666772
2022 Biallelic pathogenic variants in NUP54 clustered in the C-terminal region that interacts with NUP62 cause early-onset dystonia with striatal lesions; in silico and protein-biochemical studies confirmed these variants disrupt the NUP54–NUP62 interaction, establishing NUP54 as a disease gene for a neurodegenerative movement disorder. Patient sequencing, in silico structural modeling, protein-biochemical interaction studies Annals of neurology Medium 36333996
2022 TIP60-mediated acetylation of Nup62 at Lys432 dissolves the Nup62–Nup58–Nup54 complex during mitotic entry, promoting Nup62 redistribution to the mitotic spindle for correct spindle orientation and chromosome segregation. Mass spectrometry, co-immunoprecipitation, acetylation site mutagenesis, live-cell imaging, siRNA knockdown Journal of molecular cell biology Medium 36190325
2024 In C. elegans, the Nup54 orthologue NPP-1 promotes perinuclear localization of the anti-silencing Argonaute CSR-1, placing Nup54 in the nuclear pore machinery required for piRNA-mediated gene silencing initiation. Sensitized piRNA reporter screen, fluorescence localization assay, RNAi knockdown in C. elegans Genetics Medium 37210214

Source papers

Stage 0 corpus · 62 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 3411 32353859
2005 Towards a proteome-scale map of the human protein-protein interaction network. Nature 2090 16189514
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
2020 Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science (New York, N.Y.) 564 33060197
1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene 492 8125298
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2014 Probing nuclear pore complex architecture with proximity-dependent biotinylation. Proceedings of the National Academy of Sciences of the United States of America 436 24927568
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2013 Integrated structural analysis of the human nuclear pore complex scaffold. Cell 284 24315095
1999 The nuclear pore complex: from molecular architecture to functional dynamics. Current opinion in cell biology 281 10395558
2001 Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import. The Journal of cell biology 238 11266456
2018 Mapping the Genetic Landscape of Human Cells. Cell 225 30033366
1991 A complex of nuclear pore proteins required for pore function. The Journal of cell biology 214 2050741
2011 Next-generation sequencing to generate interactome datasets. Nature methods 200 21516116
1994 Interactions and three-dimensional localization of a group of nuclear pore complex proteins. The Journal of cell biology 187 8045926
2017 Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export. Proceedings of the National Academy of Sciences of the United States of America 183 28069952
2010 A human MAP kinase interactome. Nature methods 165 20936779
2017 Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD. Human molecular genetics 98 28040728
2017 Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans. Developmental cell 70 29065307
2010 The gsdf gene locus harbors evolutionary conserved and clustered genes preferentially expressed in fish previtellogenic oocytes. Gene 66 21047546
2011 Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network. Journal of virology 63 21994455
2007 Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport. The Journal of cell biology 51 17682050
2015 Allosteric Regulation in Gating the Central Channel of the Nuclear Pore Complex. Cell 37 26046439
2018 A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15. Biophysical journal 27 30527337
2017 Expansion of divergent SEA domains in cell surface proteins and nucleoporin 54. Protein science : a publication of the Protein Society 24 27977898
2021 Nup54-induced CARM1 nuclear importation promotes gastric cancer cell proliferation and tumorigenesis through transcriptional activation and methylation of Notch2. Oncogene 23 34725461
2014 The stoichiometry of the nucleoporin 62 subcomplex of the nuclear pore in solution. Molecular biology of the cell 22 24574455
2021 Channel nuclear pore complex subunits are required for transposon silencing in Drosophila. eLife 20 33856346
2018 Nucleoporin 54 contributes to homologous recombination repair and post-replicative DNA integrity. Nucleic acids research 17 29986057
2018 Analysis of the transcriptome data in Litopenaeus vannamei reveals the immune basis and predicts the hub regulation-genes in response to high-pH stress. PloS one 17 30517152
2021 Prevalence and functionality of intrinsic disorder in human FG-nucleoporins. International journal of biological macromolecules 15 33548309
2020 Conformation of the nuclear pore in living cells is modulated by transport state. eLife 15 33346731
2015 Ordered Regions of Channel Nucleoporins Nup62, Nup54, and Nup58 Form Dynamic Complexes in Solution. The Journal of biological chemistry 15 26025361
2022 Recessive NUP54 Variants Underlie Early-Onset Dystonia with Striatal Lesions. Annals of neurology 14 36333996
2021 Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring of female reproductive behaviors in Drosophila. BMC biology 14 34666772
2020 Integrative Analysis of DNA Methylation Identified 12 Signature Genes Specific to Metastatic ccRCC. Frontiers in oncology 12 33134164
2018 Analysis of RNA-Seq datasets reveals enrichment of tissue-specific splice variants for nuclear envelope proteins. Nucleus (Austin, Tex.) 11 29912636
2017 The Nup62 Coiled-Coil Motif Provides Plasticity for Triple-Helix Bundle Formation. Biochemistry 11 28406021
2022 Acetylation of Nup62 by TIP60 ensures accurate chromosome segregation in mitosis. Journal of molecular cell biology 10 36190325
2023 Sensitized piRNA reporter identifies multiple RNA processing factors involved in piRNA-mediated gene silencing. Genetics 8 37210214
2023 Regulation of FLC nuclear import by coordinated action of the NUP62-subcomplex and importin β SAD2. Journal of integrative plant biology 8 37278318
2009 Proteomic analysis of the effect of iptakalim on human pulmonary arterial smooth muscle cell proliferation. Acta pharmacologica Sinica 6 19169269
2023 Indel driven rapid evolution of core nuclear pore protein gene promoters. Scientific reports 4 37198214
2009 FISH-mapping comparison between river buffalo chromosome 7 and sheep chromosome 6: assignment of new loci and comparison with HSA4. Cytogenetic and genome research 4 19372676
2024 MicroRNAome profiling of breast cancer unveils hsa-miR-5683 as a tumor suppressor microRNA predicting favorable clinical outcome. Cancer cell international 3 39538254
2025 The role of ABI2 in modulating nuclear proteins: Therapeutic implications for NUP54 and NUP153 in TNBC. Advances in protein chemistry and structural biology 2 39843146
2025 Transcriptomic insights into developmental arrest in fluorescent labeling transgenic Asian elephant (Elephas maximus) embryos via inter-order cloning. Frontiers in cell and developmental biology 1 40092629
2022 An introduction to dynamic nucleoporins in Leishmania species: Novel targets for tropical-therapeutics. Journal of parasitic diseases : official organ of the Indian Society for Parasitology 1 36457769