Affinage

ZYX

Zyxin · UniProt Q15942

Round 2 corrected
Length
572 aa
Mass
61.3 kDa
Annotated
2026-04-28
44 papers in source corpus 11 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Zyxin is a LIM domain-containing mechanosensory adaptor protein that localizes to focal adhesions, stress fibers, and muscle attachment sites, where it detects mechanical force and orchestrates cytoskeletal repair and remodeling. Its C-terminal LIM domains form force-dependent assemblies at stress fiber strain sites, recruiting VASP for actin nucleation and α-actinin for crosslinking to repair ruptured actin filaments and maintain barbed-end-uniform actin bundles at focal adhesions (PMID:36384139, PMID:25252943). Zyxin also functions as a signaling adaptor downstream of integrin β1, transducing mechanical cues through FAK/AKT signaling in cancer cells and through a zyxin–14-3-3β–YAP axis that promotes inflammatory gene expression in endothelial cells under oscillatory shear stress (PMID:39143566). In C. elegans, zyxin localizes to dense bodies and M-lines in muscle and stabilizes synapses in mechanosensory neurons against locomotion-induced forces, with LIM domain-autonomous mechanosensing activity independent of α-actinin and ENA/VASP (PMID:23427270, PMID:25252943).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2002 Medium

    Initial identification of zyxin ortholog interactions in C. elegans revealed that ZYX-1 physically associates with germline RNA helicases GLH-1/GLH-4 at P granules, though no developmental phenotype resulted from zyx-1 loss, leaving its in vivo function unresolved.

    Evidence Yeast two-hybrid and GST pull-down in C. elegans

    PMID:12435362

    Open questions at the time
    • No functional phenotype observed for zyx-1 loss
    • Biological relevance of GLH interaction to zyxin's core mechanosensory role unclear
  2. 2004 Low

    Discovery that human zyxin is a phosphorylation-dependent 14-3-3-binding protein provided an early hint that zyxin participates in phospho-regulated signaling, though specific sites and downstream consequences were not identified.

    Evidence 14-3-3 affinity chromatography from HeLa extracts with PP2A dephosphorylation control

    PMID:14744259

    Open questions at the time
    • Phosphorylation site(s) mediating 14-3-3 binding not mapped
    • No functional consequence of this interaction characterized
    • Single affinity pulldown without reciprocal validation
  3. 2007 Medium

    Mapping ZYX-1 to dense bodies (Z-disc analogs) in C. elegans muscle via its interaction with the dystrophin-associated protein DYC-1 established zyxin as a component of muscle adhesion structures, paralleling its known focal adhesion localization in vertebrates.

    Evidence Yeast two-hybrid, deletion mapping, and immunofluorescence in C. elegans muscle

    PMID:18094057

    Open questions at the time
    • Functional consequence of DYC-1–ZYX-1 interaction at dense bodies not tested
    • Whether ZYX-1 is required for dense body integrity was unknown
  4. 2013 High

    Comprehensive analysis of C. elegans ZYX-1 dynamics revealed high mobility at dense bodies (FRAP), dependence on α-actinin for localization, interaction with vinculin, and nuclear shuttling, establishing zyxin as a dynamic peripheral adaptor rather than a structural scaffold, with isoform-specific roles in dystrophin-dependent muscle degeneration.

    Evidence FRAP, yeast two-hybrid, immunofluorescence, isoform-specific RNAi in C. elegans DMD model

    PMID:23427270

    Open questions at the time
    • Nuclear function of ZYX-1 not characterized
    • Mammalian relevance of isoform-specific degeneration roles unconfirmed
  5. 2014 High

    Genetic dissection in C. elegans demonstrated that zyxin's LIM domains autonomously protect mechanosensory neuron synapses from locomotion-induced mechanical forces, independent of α-actinin and VASP binding, establishing zyxin as a bona fide in vivo mechanosensor.

    Evidence Loss-of-function genetics, isoform-specific rescue, locomotion-suppression epistasis in C. elegans PLM neurons

    PMID:25252943

    Open questions at the time
    • Molecular mechanism by which LIM domains sense force at synapses not resolved
    • Whether mammalian zyxin performs analogous synapse-protective functions unknown
  6. 2020 Medium

    Identification of a ZYX–STMN1 transcriptional axis in glioblastoma revealed zyxin's capacity to regulate gene expression (STMN1 mRNA and protein), positioning it as an upstream driver of cancer cell invasion beyond its structural role.

    Evidence RNA-seq, mass spectrometry, siRNA epistasis with rescue, in vivo xenograft

    PMID:31949244

    Open questions at the time
    • Whether ZYX directly regulates STMN1 transcription or acts through intermediaries not determined
    • Generalizability beyond glioblastoma not tested
  7. 2022 High

    Demonstration that ZYX-1 is recruited to apical junctions in a tension-dependent manner during C. elegans embryonic elongation, and that zyx-1 loss enhances cadherin/catenin complex mutant phenotypes, established zyxin as a junctional mechanosensor that stabilizes actin at cell-cell contacts during morphogenesis.

    Evidence Genetic epistasis with CCC hypomorphs, live imaging, SFSS recruitment assay in vertebrate cells

    PMID:36384139

    Open questions at the time
    • Direct biochemical mechanism of tension-dependent junctional recruitment not reconstituted
    • Mammalian junctional role inferred from heterologous SFSS assay, not junctional context
  8. 2024 Medium

    Epistasis experiments in hepatocellular carcinoma cells placed zyxin downstream of integrin β1 and upstream of FAK/AKT, defining a linear ITGB1→ZYX→FAK/AKT signaling axis that promotes cancer cell proliferation and invasion.

    Evidence siRNA knockdown and overexpression rescue, immunoblotting for pathway components, in vivo xenografts

    PMID:39143566

    Open questions at the time
    • Biochemical mechanism by which ZYX activates FAK not established
    • Whether this axis operates in non-malignant integrin signaling unknown
  9. 2024 High

    In vitro reconstitution with purified proteins revealed the molecular mechanism of stress fiber repair: zyxin's LIM domains form force-dependent assemblies that bridge broken filament fragments and coordinate VASP-mediated nucleation with α-actinin crosslinking, resolving how zyxin translates mechanical damage into cytoskeletal restoration.

    Evidence In vitro reconstitution with purified proteins, single-molecule force assays, live-cell imaging (preprint)

    Open questions at the time
    • Preprint awaiting peer review
    • How force-dependent assembly is regulated by post-translational modifications in vivo not addressed
    • Stoichiometry and kinetics of multi-valent interactions not quantified in cells
  10. 2025 High

    Cryo-electron tomography of VASP/zyxin knockout cells revealed that zyxin is specifically required for organizing dense, aligned actin bundles with uniform barbed-end polarity at focal adhesions, while a tropomyosin-decorated dorsal actin layer is independent, delineating zyxin's structural contribution at sub-filament resolution.

    Evidence CRISPR KO of VASP and zyxin; cryo-ET with polarity analysis (preprint)

    Open questions at the time
    • Preprint awaiting peer review
    • Whether zyxin and VASP functions are additive or epistatic at the filament level not fully resolved
    • Contribution of other LIM domain proteins to the same actin pool not excluded
  11. 2025 Medium

    Discovery that zyxin knockout broadly enhances membrane fusion by multiple enveloped virus families suggests zyxin restricts viral entry through cytoskeletal-membrane coupling, revealing an innate antiviral function.

    Evidence CRISPR KO; quantitative cell-cell fusion assays and plaque assays for HSV-1, PRV, paramyxovirus, rhabdovirus; RNA-seq (preprint)

    Open questions at the time
    • Preprint awaiting peer review
    • Precise mechanism by which zyxin restricts membrane fusion not identified
    • In vivo antiviral role not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include: the structural basis for force-sensing by zyxin's LIM domains; how zyxin transitions between focal adhesion, stress fiber, junctional, and nuclear pools; and the mechanism by which zyxin regulates transcription of targets such as STMN1 and inflammatory genes.
  • No crystal or cryo-EM structure of full-length zyxin or its LIM domain assembly
  • Nuclear function and transcriptional mechanism largely uncharacterized
  • Post-translational modification code governing zyxin's context-dependent roles not systematically mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 5 GO:0140299 molecular sensor activity 3 GO:0060090 molecular adaptor activity 2
Localization
GO:0005856 cytoskeleton 4 GO:0005886 plasma membrane 2 GO:0005634 nucleus 1
Pathway
R-HSA-1474244 Extracellular matrix organization 2 R-HSA-162582 Signal Transduction 2 R-HSA-1500931 Cell-Cell communication 1
Partners
ACTN1FAKSTMN1VASPVCLYWHAB

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 C. elegans ZYX-1 (zyxin ortholog), a LIM domain protein, physically associates with the germline RNA helicases GLH-1 and GLH-4 at P granules, as established by yeast two-hybrid screening and confirmed by GST pull-down assays. Unlike loss of CSN-5 or KGB-1, RNAi depletion or deletion of zyx-1 produced no obvious oogenesis or P granule phenotype. Yeast two-hybrid screening of C. elegans cDNA library; GST pull-down assay Developmental biology Medium 12435362
2004 Human zyxin (ZYX) was identified as a 14-3-3-binding phosphoprotein: it was captured by 14-3-3 affinity chromatography from proliferating HeLa cell extracts and did not bind after dephosphorylation with PP2A, establishing that the interaction requires phosphorylation of ZYX. 14-3-3 affinity chromatography followed by mass spectrometric identification; dephosphorylation control with PP2A The Biochemical journal Low 14744259
2007 C. elegans DYC-1 (a dystrophin-associated protein) interacts with ZYX-1 (zyxin ortholog) at dense bodies in striated muscle. A conserved 19 amino acid sequence in DYC-1 mediates the interaction with ZYX-1 and is sufficient for DYC-1 targeting to the dense body. ZYX-1 localizes at dense bodies, M-lines, and the nucleus, and its localization suggests a role in dense body function and muscle adhesion structure stability. Yeast two-hybrid assay; deletion mapping of DYC-1 interaction domain; immunofluorescence localization in C. elegans muscles Molecular biology of the cell Medium 18094057
2013 C. elegans ZYX-1 localizes at dense bodies/Z-discs and M-lines, as well as in the nucleus of body-wall muscle. ZYX-1 interacts with DEB-1 (vinculin) and ATN-1 (α-actinin) via yeast two-hybrid. Its localization and dynamics at dense bodies depend on ATN-1. FRAP experiments revealed high mobility of ZYX-1 at dense bodies and M-lines, indicating a peripheral and dynamic association. Two isoforms (ZYX-1a and ZYX-1b) play different roles in dystrophin-dependent muscle degeneration in a C. elegans DMD model. A portion of ZYX-1 shuttles from cytoplasm to nucleus, suggesting a signal transduction role. Yeast two-hybrid; immunofluorescence; FRAP (fluorescence recovery after photobleaching); isoform-specific RNAi and deletion analysis in C. elegans DMD model Molecular biology of the cell High 23427270
2014 C. elegans ZYX-1 (zyxin ortholog) is required for synapse maintenance in PLM mechanosensory neurons. Most PLM synapses form during development but are subsequently lost in zyx-1 mutants. The synapse-stabilizing activity resides in the C-terminal LIM domain-containing short isoform. Disrupting locomotion suppresses the synaptogenesis phenotype, indicating ZYX-1 protects synapses from locomotion-induced mechanical forces. This activity is independent of α-actinin and ENA/VASP, which bind the N-terminal domain of zyxin, demonstrating autonomous LIM domain function in mechanosensing. Genetic loss-of-function analysis in C. elegans; isoform-specific transgene rescue; suppression by locomotion disruption (epistasis); immunofluorescence Development (Cambridge, England) High 25252943
2020 Human ZYX promotes glioblastoma cell invasion through positive regulation of stathmin 1 (STMN1) at both mRNA and protein levels. STMN1 knockdown phenocopies ZYX loss in reducing invasion, and STMN1 overexpression rescues the invasion defect caused by ZYX loss, establishing a ZYX–STMN1 functional axis. RNA-seq and mass spectrometry after ZYX knockdown; siRNA loss-of-function; rescue experiments with STMN1 overexpression; in vitro invasion assays; in vivo xenograft Laboratory investigation Medium 31949244
2020 A peptide derived from human ZYX (ZYX36-58, residues 36–58) inhibits invasion and migration and promotes apoptosis of ovarian cancer cells. Mechanistically, ZYX36-58 binds to and increases protein levels of thrombospondin-1 (TSP1), a tumor suppressor with antiangiogenic activity. Peptide pull-down assay; CCK8, transwell, wound healing, and flow cytometry assays; high-throughput RNA sequencing Annals of translational medicine Low 32953725
2022 C. elegans ZYX-1/Zyxin (and TES-1/Tes) are recruited to apical junctions during embryonic elongation in a tension-dependent manner. Junctional ZYX-1 recruitment requires active elongation and is severely reduced when elongation fails. zyx-1 mutants display junctional F-actin defects, and zyx-1 loss strongly enhances morphogenetic defects in hypomorphic cadherin/catenin complex (CCC) mutants. The LCR (LIM-containing repeat) domains of ZYX-1 are recruited to stress fiber strain sites (SFSSs) in cultured vertebrate cells, establishing ZYX-1 as part of a tension-sensitive system that stabilizes junctional actin during embryonic morphogenesis. Genetic analysis in C. elegans (mutants, hypomorphic combinatorial genetics); live fluorescence imaging; SFSS recruitment assay in cultured vertebrate cells Current biology : CB High 36384139
2024 Human ZYX is required for ITGB1-mediated FAK/AKT signaling and HCC cell proliferation and invasion. ZYX knockdown suppresses FAK/AKT signaling downstream of ITGB1; ZYX overexpression rescues ITGB1-overexpression-driven growth; and ZYX knockdown abolishes the promoting effect of ITGB1 overexpression. ZYX knockdown does not affect ITGB1 levels, placing ZYX downstream of ITGB1 and upstream of FAK/AKT in the ITGB1/ZYX/FAK/AKT pathway. siRNA knockdown; overexpression; immunoblotting for FAK/AKT pathway components; in vitro viability/apoptosis assays; in vivo xenograft (orthotopic and subcutaneous) Cancer cell international Medium 39143566
2025 ZYX regulates the TGF-β/SMAD signaling pathway in pancreatic acinar cells to control ferroptosis. Coumestrol (CMS) binds directly to ZYX (molecular docking), downregulates ZYX expression, and reduces TGF-β/SMAD pathway activity. ZYX overexpression counteracts CMS-mediated inhibition of TGF-β/Smad signaling and ferroptosis, placing ZYX as a positive regulator of this pathway and of acinar cell ferroptosis. Molecular docking; caerulein-induced acute pancreatitis mouse models; ZYX overexpression rescue experiments; immunoblotting for TGF-β/SMAD components; cell biology ferroptosis assays International immunopharmacology Low 40414075
2025 In prostate cancer cells, the lncRNA RAD51-AS1 recruits HNRNPC in the nucleus to bind pre-RARA mRNA and positively modulate RARA expression. RARA then activates ZYX transcription to enhance ZYX expression, and increased ZYX suppresses PCa cell migration and invasion. This RAD51-AS1/HNRNPC/RARA/ZYX axis was established by rescue experiments showing that ZYX knockdown reverses the anti-migratory effect of RAD51-AS1. RT-qPCR; RIP assay; chromatin immunoprecipitation (ChIP) for RARA at ZYX promoter; rescue knockdown experiments; transwell migration/invasion assays Discover oncology Medium 41134509
2024 Human zyxin acts as a mechanosensor in endothelial cells that promotes oscillatory shear stress (OSS)-induced inflammation and atherosclerosis. Mechanistically, under OSS, zyxin binds to 14-3-3β and inhibits 14-3-3β-mediated phosphorylation of YAP at Serine 127, thereby enhancing YAP nuclear translocation and endothelial inflammatory gene expression. Endothelial-specific zyxin deletion (Zyxin iECKO ApoE−/−) reverses OSS-driven endothelial activation and reduces atherosclerosis in vivo. Endothelial-specific conditional knockout mouse model (Zyxin iECKO ApoE−/−); disturbed flow in vitro (Ibidi system); co-immunoprecipitation of zyxin with 14-3-3β; YAP phosphorylation (Ser127) immunoblotting; qPCR for inflammatory markers bioRxiv (preprint)preprint Medium
2024 Human zyxin detects force-induced ruptures in actin-myosin stress fibers and coordinates repair by forming force-dependent assemblies via its LIM domains that bridge broken filament fragments. These assemblies engage repair factors through multi-valent interactions: zyxin coordinates nucleation of new F-actin by VASP and crosslinking into aligned bundles by α-actinin. Stress fiber repair initiates within the cores of micron-scale damage sites, explaining rapid restoration of F-actin-depleted regions. In vitro reconstitution with purified proteins; single-molecule force assays; live-cell imaging of stress fiber repair; loss-of-function analysis bioRxiv (preprint)preprint High
2025 Human zyxin broadly restricts viral fusion and entry across multiple enveloped virus families. Zyxin-knockout RPE cells show enhanced cell-cell fusion activity with HSV-1, pseudorabies virus (PRV), paramyxovirus, and rhabdovirus fusion proteins, and larger plaques following infection with each viral family. Bulk RNA sequencing of zyxin-KO vs. wild-type cells identified 18 differentially expressed genes enriched in ontology groups including extracellular matrix organization, cell-cell adhesion, and MAPK cascade regulation, suggesting that zyxin modulates membrane properties or cytoskeletal organization to restrict viral membrane fusion. CRISPR/Cas9 zyxin knockout; quantitative cell-cell fusion assay; plaque size analysis for HSV-1, PRV, paramyxovirus, rhabdovirus; bulk RNA sequencing bioRxiv (preprint)preprint Medium
2025 Human zyxin and VASP cooperate to organize focal adhesion (FA)-associated actin filaments. CRISPR/Cas9 knockout of VASP and/or zyxin impairs adhesion dynamics and alters FA morphology. Cryo-electron tomography revealed that loss of VASP and zyxin disrupts the assembly of dense, aligned actin bundles with uniform barbed-end polarity toward the cell edge; a tropomyosin-decorated dorsal actin layer remains unaffected. This establishes zyxin's specific role in maintaining the polarity and organization of the adhesion-associated actin network. CRISPR/Cas9 knockout of VASP and zyxin; cryo-electron tomography (cryo-ET) with filament polarity analysis; FA dynamics imaging bioRxiv (preprint)preprint High
2025 In brain endothelial cells, zyxin expression inversely correlates with claudin-5 levels during blood-brain barrier (BBB) maturation, and this inverse relationship is recapitulated in mice and in human temporal lobe epilepsy patients with BBB dysfunction. Mechanistically, increasing mechanical loads shift from cell-matrix adhesions to cell-cell junctions during BBB maturation, with zyxin and vinculin being markers of the cell-matrix adhesion force-bearing system that is inversely regulated relative to tight junction strength. Super-resolution imaging; biophysical tension measurements in human stem cell-derived endothelial cells; immunofluorescence in mouse and human tissue; BBB permeability assays bioRxiv (preprint)preprint Low

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2861 17081983
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2006 A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nature biotechnology 1336 16964243
2004 Large-scale characterization of HeLa cell nuclear phosphoproteins. Proceedings of the National Academy of Sciences of the United States of America 1159 15302935
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2008 Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 787 18854154
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 610 16713569
2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nature cell biology 490 21423176
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell 423 26871637
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2004 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. The Biochemical journal 372 14744259
2015 Aerobic glycolysis tunes YAP/TAZ transcriptional activity. The EMBO journal 362 25796446
2007 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America 360 17620599
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2020 Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis. Med (New York, N.Y.) 291 32838362
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
2011 A directed protein interaction network for investigating intracellular signal transduction. Science signaling 258 21900206
2004 Functional proteomics mapping of a human signaling pathway. Genome research 247 15231748
2014 Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. Journal of proteomics 215 25281560
2016 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nature communications 211 27173435
2002 The GLH proteins, Caenorhabditis elegans P granule components, associate with CSN-5 and KGB-1, proteins necessary for fertility, and with ZYX-1, a predicted cytoskeletal protein. Developmental biology 59 12435362
2020 Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme. Laboratory investigation; a journal of technical methods and pathology 21 31949244
2013 ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration. Molecular biology of the cell 20 23427270
2007 DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1. Molecular biology of the cell 19 18094057
2024 Anti-diabetic and anti-inflammatory indole diterpenes from the marine-derived fungus Penicillium sp. ZYX-Z-143. Bioorganic chemistry 18 38387395
2014 The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans. Development (Cambridge, England) 18 25252943
2011 QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells. Cancer science 14 21920000
2009 Association of ZYX polymorphisms with carcass and meat quality traits in commercial pigs. Meat science 9 20374769
2020 Peptidome characterization of ovarian cancer serum and the identification of tumor suppressive peptide ZYX36-58. Annals of translational medicine 6 32953725
2022 TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo. Current biology : CB 5 36384139
2024 Persteroid, a new steroid from the marine-derived fungus Penicillium sp. ZYX-Z-143. Natural product research 4 39225394
2025 Network pharmacology analysis reveals that coumestrol targets ZYX to inhibit ferroptosis and alleviate acute pancreatitis. International immunopharmacology 0 40414075
2025 RAD51-AS1 inhibits the migration and invasion of prostate cancer cells by up-regulating RARA to activate ZYX transcription. Discover oncology 0 41134509
2024 Does rAj-Tspin, a novel peptide from A. japonicus, exert antihepatocellular carcinoma effects via the ITGB1/ZYX/FAK/AKT signaling pathway? Cancer cell international 0 39143566