Affinage

YWHAB

14-3-3 protein beta/alpha · UniProt P31946

Round 2 corrected
Length
246 aa
Mass
28.1 kDa
Annotated
2026-04-28
41 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

YWHAB (14-3-3β/α) is a phosphoserine-binding scaffold protein that forms dimers and sequesters phosphorylated client proteins in the cytoplasm, thereby controlling signaling cascades spanning apoptosis, cell growth, transcription, and metabolism. It recognizes conserved RSXpSXP and related phosphoserine motifs to bind and retain diverse clients—including BAD, Raf-1, HDAC4/5, TORC2, YAP, FoxO, and TSC2—preventing their translocation to mitochondria or the nucleus, which regulates apoptotic commitment, CREB-dependent transcription, Hippo pathway output, and mTORC1 activity (PMID:9428519, PMID:10195903, PMID:10869435, PMID:15454081, PMID:17974916, PMID:18198340). YWHAB also forms a phosphorylation-dependent complex with the glucagon receptor and FOXO1 to suppress hepatic gluconeogenesis, a function demonstrated by impaired glucose homeostasis in Ywhab knockout mice (PMID:33641163). YWHAB protein stability is itself regulated by OTUB1-mediated deubiquitination, and pharmacological disruption of YWHAB dimerization by Kuwanon A blocks MAPK signaling, establishing the dimer interface as a druggable target (PMID:39270917, PMID:41090717).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1997 High

    Defining the molecular recognition code: crystallographic and biochemical demonstration that 14-3-3 proteins recognize discrete phosphoserine motifs and bind bidentately to tandem-phosphorylated partners established the biophysical basis for how YWHAB engages its entire client repertoire.

    Evidence Phosphoserine peptide library screening plus 2.6 Å X-ray structure of 14-3-3ζ–phosphopeptide complex

    PMID:9428519

    Open questions at the time
    • Isoform-specific binding preferences among 14-3-3 family members not resolved
    • No structural data for YWHAB homodimer specifically
    • In vivo relevance of bidentate versus monodentate binding not tested
  2. 1997 Medium

    Placing 14-3-3β in a canonical signaling pathway: evidence that phosphorylation-dependent 14-3-3 binding to Raf-1 is required for Raf activation connected YWHAB to MAPK cascade regulation.

    Evidence Co-immunoprecipitation and kinase activity assays across multiple labs (review synthesis)

    PMID:9069260

    Open questions at the time
    • Relative contribution of YWHAB versus other 14-3-3 isoforms to Raf-1 regulation unclear
    • Mechanism by which 14-3-3 activates versus merely stabilizes Raf-1 not dissected
  3. 1999 High

    Establishing the cytoplasmic sequestration paradigm for apoptosis control: demonstration that 14-3-3 retains phospho-BAD in the cytosol and that calcineurin-mediated dephosphorylation releases BAD to mitochondria to promote apoptosis defined a general model of 14-3-3 as a phosphorylation-dependent spatial gatekeeper.

    Evidence Co-immunoprecipitation, subcellular fractionation, pharmacological and genetic calcineurin perturbation in hippocampal neurons

    PMID:10195903

    Open questions at the time
    • Which 14-3-3 isoform is rate-limiting for BAD sequestration in vivo not determined
    • Stoichiometry of 14-3-3–BAD complex under physiological conditions unknown
  4. 2000 High

    Extending the sequestration model to transcription: 14-3-3 binding to phosphorylated HDAC4/5 was shown to control their nucleo-cytoplasmic shuttling, directly linking 14-3-3 scaffold function to chromatin regulation and gene expression.

    Evidence Co-immunoprecipitation, phosphosite mutagenesis, subcellular localization, transcriptional reporter assays

    PMID:10869435

    Open questions at the time
    • Identity of kinases regulating 14-3-3–HDAC interaction in different cell types not fully mapped
    • Isoform specificity of 14-3-3 for HDAC4 versus HDAC5 not resolved
  5. 2004 High

    Defining 14-3-3 as a coincidence detector component: TORC2 was shown to be retained in the cytoplasm by 14-3-3 under basal conditions; concurrent calcium and cAMP signals release TORC2 for nuclear CREB activation, positioning 14-3-3 as a signal integration node.

    Evidence Co-immunoprecipitation, subcellular fractionation, luciferase reporters, pharmacological/dominant-negative perturbation

    PMID:15454081

    Open questions at the time
    • Whether YWHAB versus other 14-3-3 isoforms preferentially bind TORC2 not tested
    • In vivo physiological relevance in specific tissues not established at this point
  6. 2007 High

    Connecting 14-3-3 to the Hippo tumor-suppressor pathway: Lats-phosphorylated YAP was found to be sequestered by 14-3-3 in the cytoplasm, establishing 14-3-3 as the effector arm that enforces Hippo-mediated growth suppression.

    Evidence Co-immunoprecipitation, kinase assays, subcellular fractionation, YAP mutagenesis, Drosophila and mammalian genetic epistasis

    PMID:17974916

    Open questions at the time
    • Relative contribution of individual 14-3-3 isoforms to YAP retention not dissected
    • Whether 14-3-3–YAP binding is regulated by additional post-translational modifications unknown
  7. 2008 High

    Revealing a competitive displacement mechanism for mTOR regulation: REDD1 was shown to compete with TSC2 for 14-3-3 binding under hypoxia, liberating TSC2 to suppress mTORC1, establishing that 14-3-3 client switching can redirect signaling output.

    Evidence Co-immunoprecipitation, site-directed mutagenesis of 14-3-3 binding sites, REDD1 KO cells, in vitro competition assays, mouse tumor model

    PMID:18198340

    Open questions at the time
    • Quantitative binding affinities of REDD1 versus TSC2 for YWHAB not measured
    • Whether other stresses use analogous displacement mechanisms via 14-3-3 not explored
  8. 2010 High

    Dual-mode YAP suppression clarified: beyond 14-3-3-mediated cytoplasmic retention (spatial), Lats-dependent priming at Ser381 triggers CK1δ/ε phosphorylation and SCF(β-TRCP)-mediated YAP degradation (temporal), delineating two distinct regulatory arms.

    Evidence Co-immunoprecipitation, ubiquitination assays, phosphosite mutagenesis, cycloheximide chase, mass spectrometry

    PMID:20048001

    Open questions at the time
    • Relative quantitative contribution of 14-3-3 retention versus degradation to YAP suppression in different tissues not determined
    • Whether 14-3-3 binding protects YAP from degradation or merely prevents nuclear access not fully resolved
  9. 2021 High

    A metabolic role for YWHAB established: YWHAB forms a phosphorylation-dependent complex with the glucagon receptor and FOXO1 to inhibit hepatic gluconeogenesis, as demonstrated by impaired glucose homeostasis in Ywhab knockout mice.

    Evidence Affinity purification–mass spectrometry, co-immunoprecipitation, Ywhab KO mice, primary hepatocyte deletion, pyruvate tolerance tests

    PMID:33641163

    Open questions at the time
    • Whether YWHAB directly bridges GCGR and FOXO1 simultaneously or acts sequentially not resolved
    • Contribution of other 14-3-3 isoforms to gluconeogenic regulation not assessed
  10. 2023 Medium

    YWHAB activates PI3K/AKT signaling in colon cancer through binding PIK3R2: YWHAB knockdown reduced phospho-PI3K and phospho-AKT, and PIK3R2 overexpression rescued these effects, positioning YWHAB upstream of PI3K activation.

    Evidence Co-immunoprecipitation, siRNA knockdown with rescue, Western blot pathway readouts, flow cytometry

    PMID:37090079

    Open questions at the time
    • Mechanism by which YWHAB stabilizes or activates PIK3R2 not determined
    • Single-lab finding; independent replication needed
    • Whether this represents a general mechanism or is context-specific to colon cancer unclear
  11. 2024 High

    YWHAB protein stability is directly controlled by OTUB1-mediated deubiquitination, linking ubiquitin pathway regulation to hepatic glucose metabolism: hepatic OTUB1 deletion decreases YWHAB levels, elevates fasting glucose, and increases gluconeogenic gene expression.

    Evidence Co-immunoprecipitation, in vitro deubiquitination assay, hepatic OTUB1 KO in db/db mice, glucose tolerance tests

    PMID:39270917

    Open questions at the time
    • Ubiquitin chain type(s) on YWHAB removed by OTUB1 not characterized
    • E3 ligase(s) responsible for YWHAB ubiquitination not identified
    • Whether OTUB1 regulates other 14-3-3 isoforms not tested
  12. 2025 Medium

    The YWHAB dimer interface is druggable: Kuwanon A directly binds YWHAB and induces dimer dissociation, blocking MAPK signaling and inhibiting hepatocellular carcinoma growth in vivo, demonstrating pharmacological tractability of the 14-3-3β scaffold.

    Evidence Direct binding assays, dimer dissociation assays, MAPK Western blots, xenograft mouse model, sorafenib combination

    PMID:41090717

    Open questions at the time
    • Binding site and structural basis of Kuwanon A–YWHAB interaction not resolved at atomic level
    • Selectivity of Kuwanon A across 14-3-3 isoforms not assessed
    • Single-lab finding; independent pharmacological validation needed

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis for YWHAB isoform-specific client selectivity, the identity of E3 ubiquitin ligase(s) targeting YWHAB for degradation, and whether competitive client displacement (as shown for REDD1/TSC2) is a widespread regulatory mechanism across YWHAB's diverse client repertoire.
  • No high-resolution structure of YWHAB homodimer with a full-length client
  • Systematic isoform-specific client profiling not performed
  • E3 ligase(s) for YWHAB ubiquitination unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 8 GO:0098772 molecular function regulator activity 5
Localization
GO:0005829 cytosol 5
Pathway
R-HSA-162582 Signal Transduction 7 R-HSA-1430728 Metabolism 2 R-HSA-5357801 Programmed Cell Death 2 R-HSA-74160 Gene expression (Transcription) 2
Partners
BADFOXO1HDAC4HDAC5OTUB1RAF1TSC2YAP1

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 14-3-3 proteins (including the beta isoform, YWHAB) bind phosphoserine-containing motifs (RSXpSXP and RXY/FXpSXP) present in nearly all known 14-3-3 binding partners. Crystal structure of 14-3-3zeta complexed with a phosphoserine motif revealed the bound peptide in an extended conformation with a cis-Pro at pS+2, and showed that the 14-3-3 dimer binds tightly to molecules with tandem phosphoserine motifs (bidentate association), implicating this as a signaling mechanism for partners such as Raf, BAD, and Cbl. Phosphoserine-oriented peptide library screening of all mammalian and yeast 14-3-3 isoforms; X-ray crystallography (2.6 Å resolution) of 14-3-3zeta/phosphopeptide complex; in vitro binding assays Cell High 9428519
1997 14-3-3 proteins (including beta/YWHAB) bind Raf-1 in a phosphorylation-dependent manner and are required for Raf-1 activation, placing 14-3-3 as an essential component of the Raf-1 activation mechanism in response to signaling events. Co-immunoprecipitation, functional kinase assays, phosphorylation site analysis reviewed across multiple studies Current opinion in cell biology Medium 9069260
1999 14-3-3 proteins (including YWHAB) bind phosphorylated BAD in the cytosol, preventing its translocation to mitochondria. Ca2+-activated calcineurin dephosphorylates BAD, causing its dissociation from 14-3-3 and translocation to mitochondria where it heterodimerizes with Bcl-xL and promotes apoptosis. Co-immunoprecipitation, subcellular fractionation, dominant-negative calcineurin expression, pharmacological calcineurin inhibitors, hippocampal neuron imaging Science High 10195903
2000 14-3-3 proteins (including YWHAB) interact with HDAC4 and HDAC5 at three phosphorylation sites, sequestering these class II HDACs in the cytoplasm. Loss of 14-3-3 interaction allows HDAC4/5 to translocate to the nucleus, interact with HDAC3, and repress gene expression, thus controlling transcriptional activity through regulated nuclear-cytoplasmic shuttling. Co-immunoprecipitation, subcellular localization studies, transcriptional reporter assays, phosphorylation-site mutagenesis Proceedings of the National Academy of Sciences of the United States of America High 10869435
2004 14-3-3 proteins (including YWHAB) sequester the CREB coactivator TORC2 in the cytoplasm via a phosphorylation-dependent interaction under resting conditions. Calcium and cAMP signals promote dephosphorylation of TORC2 via calcineurin and inhibition of SIK2 kinase, disrupting TORC2:14-3-3 complexes and allowing TORC2 nuclear entry and CREB-dependent gene activation, establishing 14-3-3 as a cytoplasmic anchor in a calcium/cAMP coincidence detector module. Co-immunoprecipitation, subcellular fractionation, luciferase reporter assays, dominant-negative and pharmacological inhibitor studies Cell High 15454081
2007 14-3-3 proteins (including YWHAB) bind phosphorylated YAP (at Ser127 by Lats kinase) and mediate its cytoplasmic sequestration, thereby inactivating the YAP oncoprotein. This 14-3-3-dependent cytoplasmic retention is the key mechanism by which the Hippo pathway suppresses YAP transcriptional activity in response to cell contact inhibition. Co-immunoprecipitation, phosphorylation assays, subcellular fractionation/immunofluorescence, Lats kinase loss-of-function, YAP mutational analysis in vivo (Drosophila and mammalian cells) Genes & development High 17974916
2008 14-3-3 proteins (including YWHAB) bind TSC2 under growth factor conditions, inhibiting the TSC1/2 complex (a negative regulator of mTORC1). Under hypoxia, REDD1 competitively binds 14-3-3, displacing TSC2 and freeing it to suppress mTORC1 activity. REDD1 mutants unable to bind 14-3-3, and TSC2 mutants unable to bind 14-3-3, abrogate hypoxia-dependent mTORC1 regulation. Co-immunoprecipitation, site-directed mutagenesis of 14-3-3 binding sites, REDD1 knockout cells, in vitro competition assays, mouse tumor model Genes & development High 18198340
2010 14-3-3 proteins (including YWHAB) bind phospho-Ser127 of YAP; additionally Lats phosphorylates YAP at Ser381, which primes subsequent CK1δ/ε phosphorylation to create a phosphodegron that recruits SCF(β-TRCP) E3 ubiquitin ligase, leading to YAP ubiquitination and degradation. Thus 14-3-3 mediates spatial regulation (cytoplasmic retention) while the phosphodegron mediates temporal regulation (degradation) to coordinately suppress YAP oncogenic activity. Co-immunoprecipitation, ubiquitination assays, phosphorylation site mutagenesis, cycloheximide chase, mass spectrometry Genes & development High 20048001
2011 14-3-3 proteins (including YWHAB) bind AKT-phosphorylated FoxO transcription factors, sequestering them in the cytoplasm and preventing FoxO-dependent transcription of pro-apoptotic and cell-cycle arrest genes. This interaction forms a key node in insulin/IGF-1 signaling downstream of AKT. Co-immunoprecipitation, subcellular fractionation, phosphorylation assays, AKT mutant studies, transcriptional reporter assays; reviewed from multiple independent studies Biochimica et biophysica acta High 21708191
2020 YWHAB directly interacts with the PCV2 viral protein ORF5, as confirmed by protein-protein interaction assays. YWHAB expression is induced upon ORF5 overexpression and PCV2 infection; YWHAB overexpression strongly inhibits PCV2 replication and suppresses PCV2-induced ER stress, autophagy, ROS production, and apoptosis, while YWHAB knockdown exacerbates these cellular responses. Co-immunoprecipitation, protein-protein interaction assays, ectopic overexpression and gene knockdown (siRNA), viral replication assays, ER stress markers, autophagy flux assays, ROS measurement, flow cytometry (apoptosis) Veterinary microbiology Medium 33096469
2021 YWHAB forms a phosphorylation-dependent complex with the glucagon receptor (GCGR) and directly interacts with FOXO1 to inhibit glucagon-mediated hepatic glucose production. Ywhab knockout mice show impaired blood glucose homeostasis under pyruvate stimulation, and deletion in primary hepatocytes increases gluconeogenic output. YWHAB thus acts as an inhibitor of glucagon-induced hepatic gluconeogenesis. Affinity purification/mass spectrometry (initial identification), co-immunoprecipitation, Ywhab knockout mice, primary hepatocyte deletion, glucose production assays, pyruvate tolerance tests FEBS letters High 33641163
2021 In cervical cancer cells, circ-SMARCA5 binds SND1 protein (verified by RNA pulldown), preventing SND1 from interacting with YWHAB (verified by co-immunoprecipitation). This circ-SMARCA5–SND1 interaction thereby downregulates YWHAB activity, and knockdown of SND1 or YWHAB reverses the pro-proliferative/pro-invasive effects of circ-SMARCA5 siRNA, establishing YWHAB as a downstream effector of the circ-SMARCA5/SND1 axis in cervical cancer. RNA pulldown assay (circ-SMARCA5 with SND1), co-immunoprecipitation (SND1–YWHAB), siRNA knockdown of SND1/YWHAB, CCK-8, Transwell invasion, Annexin V apoptosis assays, in vivo xenograft Cell transplantation Medium 33588586
2023 YWHAB binds PIK3R2 (PI3K regulatory subunit 2) in colon cancer cells, as demonstrated by co-immunoprecipitation. YWHAB knockdown decreases PIK3R2 expression and reduces PI3K/AKT pathway activation (decreased p-PI3K and p-AKT levels), causing G0/G1 cell cycle arrest and apoptosis. PIK3R2 overexpression rescues the effects of YWHAB knockdown, placing YWHAB upstream of PIK3R2 in activating the PI3K/AKT pathway. Co-immunoprecipitation (YWHAB–PIK3R2), siRNA knockdown, overexpression plasmid rescue, Western blotting (PI3K/AKT pathway), flow cytometry (cell cycle, apoptosis), CCK-8, TUNEL assay Experimental and therapeutic medicine Medium 37090079
2024 The deubiquitinase OTUB1 directly interacts with YWHAB and deubiquitinates it through a catalytic mechanism, thereby stabilizing YWHAB protein levels. OTUB1-mediated YWHAB stabilization in turn suppresses hepatic gluconeogenesis. Deletion of hepatic OTUB1 reduces YWHAB levels, elevates fasting blood glucose, and increases gluconeogenic gene expression; OTUB1 overexpression mitigates diabetic hyperglycemia. Co-immunoprecipitation (OTUB1–YWHAB), in vitro deubiquitination assay, hepatic OTUB1 knockout mice (db/db model), hepatocyte overexpression, glucose tolerance tests, gluconeogenic gene expression analysis Cellular signalling High 39270917
2024 YWHAB overexpression inhibits migration and invasion of MDA-MB-231 breast cancer cells without affecting proliferation, while YWHAB knockdown promotes migration and invasion of MCF7 cells. Transcriptomic analysis showed YWHAB overexpression downregulates vimentin (a mesenchymal marker), suggesting YWHAB suppresses epithelial-to-mesenchymal properties. The transcription factor IRX5 regulates YWHAB expression by binding its promoter region, as demonstrated by dual luciferase assay. Overexpression and siRNA knockdown, migration/invasion assays (Transwell), transcriptomics (RNA-seq), vimentin Western blot, dual luciferase promoter assay (IRX5 regulation) Oncology letters Medium 39119237
2025 The small molecule Kuwanon A (KA) directly targets YWHAB and mediates dimer dissociation of the YWHAB dimer, thereby inhibiting the MAPK (Raf/MEK/ERK) signaling pathway, causing cell cycle arrest and inhibiting migration/invasion of hepatocellular carcinoma cells both in vitro and in vivo. Combination with sorafenib showed synergistic anti-tumor effects. Target identification (direct binding assays), dimer dissociation assays, MAPK pathway Western blotting, cell cycle assays, migration/invasion assays, in vivo xenograft mouse model Cells Medium 41090717

Source papers

Stage 0 corpus · 41 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes & development 2582 17974916
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
1997 The structural basis for 14-3-3:phosphopeptide binding specificity. Cell 1405 9428519
2010 Network organization of the human autophagy system. Nature 1286 20562859
2009 Defining the human deubiquitinating enzyme interaction landscape. Cell 1282 19615732
2016 ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell 1233 26777405
2010 A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes & development 1225 20048001
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2001 Nerve growth factor signaling, neuroprotection, and neural repair. Annual review of neuroscience 1029 11520933
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
1999 Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science (New York, N.Y.) 970 10195903
2004 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nature cell biology 841 14743216
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2011 FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. Biochimica et biophysica acta 593 21708191
2011 Global landscape of HIV-human protein complexes. Nature 593 22190034
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
2008 Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes & development 580 18198340
2010 The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Developmental cell 573 21145499
2004 The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 549 15454081
1997 The complexity of Raf-1 regulation. Current opinion in cell biology 541 9069260
1997 Signal transduction by the neurotrophin receptors. Current opinion in cell biology 516 9069267
2011 ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell 508 22078878
2011 Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell 507 21565611
2000 Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proceedings of the National Academy of Sciences of the United States of America 506 10869435
2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nature cell biology 490 21423176
2021 Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer. Cell transplantation 26 33588586
2020 MiR-129-5p sensitization of lung cancer cells to etoposide-induced apoptosis by reducing YWHAB. Journal of Cancer 25 31949489
2021 The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1. FEBS letters 14 33641163
2020 A novel PCV2 ORF5-interacting host factor YWHAB inhibits virus replication and alleviates PCV2-induced cellular response. Veterinary microbiology 9 33096469
2023 YWHAB knockdown inhibits cell proliferation whilst promoting cell cycle arrest and apoptosis in colon cancer cells through PIK3R2. Experimental and therapeutic medicine 8 37090079
2024 YWHAB is regulated by IRX5 and inhibits the migration and invasion of breast cancer cells. Oncology letters 6 39119237
2012 Lack of association between 14-3-3 beta gene (YWHAB) polymorphisms and sporadic Creutzfeldt-Jakob disease (CJD). Molecular biology reports 5 23053962
2024 miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis. Pediatric surgery international 3 38431920
2025 Kuwanon A Targeted YWHAB in Hepatocellular Carcinoma Cells to Inhibit the Raf/MEK/ERK Signaling Pathway. Cells 0 41090717
2024 The deubiquitinase OTUB1 inhibits gluconeogenesis by stabilizing YWHAB. Cellular signalling 0 39270917
2023 Expression of the NUP153 and YWHAB genes from their canonical promoters and alternative promoters of the LINE-1 retrotransposon in the placenta of the first trimester of pregnancy. Vavilovskii zhurnal genetiki i selektsii 0 36923475