Affinage

YWHAE

14-3-3 protein epsilon · UniProt P62258

Length
255 aa
Mass
29.2 kDa
Annotated
2026-04-28
75 papers in source corpus 17 papers cited in narrative 17 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

YWHAE encodes the 14-3-3ε scaffold protein, which regulates diverse cellular processes—including neuronal migration, mTORC1-dependent protein synthesis, autophagy, cardiac electrophysiology, and spermatogenesis—by binding phosphorylated client proteins and modulating their activity, localization, or stability. In neurons, 14-3-3ε stabilizes doublecortin to control neurite formation and participates in an NDEL1/LIS1/DISC1 complex essential for cortical development; heterozygous loss-of-function variants in humans cause a neurodevelopmental disorder with corpus callosum hypoplasia and ventricular dilatation (PMID:28173130, PMID:36999555, PMID:18658164). 14-3-3ε promotes mTORC1 signaling by sequestering the TSC1/TSC2 complex, and its crotonylation at K73/K78 during leucine deprivation releases the phosphatase PPM1B to dephosphorylate ULK1 and activate autophagy (PMID:32187357, PMID:36628438). Beyond canonical phosphoprotein scaffolding, 14-3-3ε binds TBX5 mRNA to reduce its stability and thereby limits NaV1.5 cardiac sodium channel expression, and it retains YAP1 in the cytoplasm to restrain Hippo pathway transcriptional output (PMID:38750908, PMID:38407929).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2008 Medium

    Establishing that YWHAE participates in a neurodevelopmental protein complex (with DISC1, NUDEL, LIS1) and that haploinsufficiency produces cognitive and behavioral deficits addressed whether 14-3-3ε has non-redundant roles in brain function.

    Evidence Ywhae heterozygous knockout mice showing 50% protein reduction with working memory and anxiety phenotypes

    PMID:18658164

    Open questions at the time
    • Direct demonstration of DISC1/NUDEL binding not shown in this study
    • Mechanism linking reduced 14-3-3ε to behavioral deficits not resolved
    • Contribution of individual complex members unclear
  2. 2016 High

    Identification of doublecortin as a direct 14-3-3ε client revealed a specific mechanism by which YWHAE controls neurite morphogenesis — by preventing doublecortin degradation and thereby regulating microtubule dynamics in developing neurons.

    Evidence Co-IP, in vitro binding, conditional Ywhae knockout mouse, live imaging with doublecortin knockdown rescue

    PMID:28173130

    Open questions at the time
    • Phosphorylation site on doublecortin mediating 14-3-3ε binding not mapped
    • Whether other 14-3-3 isoforms compensate in vivo unknown
  3. 2016 Medium

    Demonstrating that YWHAE negatively regulates CDC25B and MYC in gastric cancer established a tumor-suppressive role for 14-3-3ε in restraining cell cycle progression and invasion.

    Evidence siRNA knockdown/overexpression in gastric cancer cells with proliferation, invasion, and in vivo xenograft assays

    PMID:27863420

    Open questions at the time
    • Direct binding between 14-3-3ε and CDC25B/MYC not demonstrated
    • Whether this regulation is phosphorylation-dependent unknown
  4. 2018 Medium

    Discovery that H. pylori CagA hijacks YWHAE to enhance NF-κB transactivation revealed 14-3-3ε as a host factor exploited by a bacterial oncoprotein.

    Evidence Yeast two-hybrid, GST pulldown, Co-IP, and NF-κB reporter assays

    PMID:29106533

    Open questions at the time
    • Phosphorylation dependence of CagA–14-3-3ε interaction not fully mapped
    • In vivo relevance to gastric carcinogenesis not tested
  5. 2020 High

    Showing that 14-3-3ε promotes mTORC1 activity by sequestering the TSC1/TSC2 inhibitory complex defined a direct mechanism by which YWHAE drives protein synthesis in myeloma cells.

    Evidence Co-IP, siRNA/KO, protein synthesis assays including immunoglobulin light chain secretion in multiple myeloma lines

    PMID:32187357

    Open questions at the time
    • Which phospho-sites on TSC2 mediate 14-3-3ε binding not resolved
    • Whether this mechanism operates in non-malignant contexts unknown
  6. 2020 High

    Demonstrating that testis-specific and global Ywhae knockout causes male infertility with abnormal spermatozoa morphology and motility established 14-3-3ε as essential for spermatogenesis, acting through GSK3 and PP1γ2 phosphorylation.

    Evidence Conditional and global knockout mouse models with CASA, immunohistochemistry, and phospho-protein analysis

    PMID:32657535

    Open questions at the time
    • Direct substrates mediating 14-3-3ε effects on sperm capacitation uncharacterized
    • Whether other 14-3-3 isoforms partially compensate in testis unclear
  7. 2021 High

    Characterization of the YWHAE-NUTM2 fusion oncoprotein as a scaffold that co-recruits BRAF/RAF1 and YAP/TAZ to drive MAPK signaling and cyclin D1 expression explained the oncogenic mechanism of this translocation in high-grade endometrial stromal sarcoma.

    Evidence Reciprocal Co-IP, siRNA knockdown, pharmacological MEK/CDK4/6 inhibition in HG-ESS cell lines

    PMID:33947829

    Open questions at the time
    • Whether NUTM2 fusion alters 14-3-3ε client specificity beyond BRAF/YAP unknown
    • Structural basis of the fusion oncoprotein not determined
  8. 2023 High

    Discovery that crotonylation of 14-3-3ε at K73/K78 during leucine deprivation releases PPM1B to activate ULK1-dependent autophagy uncovered a post-translational switch converting YWHAE from an autophagy suppressor to a permissive state.

    Evidence Crotonylome mass spectrometry, K73R/K78R mutagenesis, molecular dynamics, Co-IP showing PPM1B release

    PMID:36628438

    Open questions at the time
    • Writers responsible for 14-3-3ε crotonylation not identified
    • Whether crotonylation affects other 14-3-3ε client interactions globally unknown
  9. 2023 High

    Establishing that heterozygous YWHAE loss-of-function variants cause a human neurodevelopmental disorder with corpus callosum hypoplasia and ventricular dilatation, recapitulated in Ywhae-knockout mice, confirmed YWHAE as a Mendelian disease gene.

    Evidence Human genetic cohort with SNVs/CNVs, Ywhae knockout mouse neuroanatomy, MRI

    PMID:36999555

    Open questions at the time
    • Precise neuronal migration defect underlying human phenotype not delineated at cellular level
    • Genotype-phenotype correlations across variant types incomplete
  10. 2024 High

    Revealing that 14-3-3ε binds TBX5 mRNA and reduces its stability, thereby limiting NaV1.5 sodium channel transcription, established an unexpected RNA-binding function for a canonical phosphoprotein scaffold and linked it to cardiac arrhythmia.

    Evidence RNA immunoprecipitation, patch clamp electrophysiology, AAV9-mediated in vivo knockdown with ECG

    PMID:38750908

    Open questions at the time
    • RNA-binding domain or motif within 14-3-3ε not mapped
    • Whether 14-3-3ε regulates other cardiac mRNAs unknown
  11. 2024 Medium

    Demonstrating that ANKZF1 competitively displaces YAP1 from YWHAE, promoting YAP1 nuclear import and lymphangiogenesis in renal cell carcinoma, clarified how YWHAE-mediated cytoplasmic retention of YAP1 is modulated in cancer.

    Evidence Co-IP, mass spectrometry, site-specific mutations, immunofluorescence in clear-cell RCC

    PMID:38407929

    Open questions at the time
    • Phospho-sites on YAP1 critical for YWHAE retention not mapped in this study
    • In vivo validation in RCC models limited

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis for 14-3-3ε's RNA-binding activity, how crotonylation versus phospho-client binding are coordinated globally, and the extent to which 14-3-3ε functions non-redundantly relative to other 14-3-3 isoforms in specific tissues.
  • No structural model of 14-3-3ε bound to RNA
  • Systematic mapping of isoform-specific versus shared clients not performed
  • Integration of crotonylation with other PTMs on 14-3-3ε unexplored

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 6 GO:0098772 molecular function regulator activity 4 GO:0003723 RNA binding 1
Localization
GO:0005829 cytosol 2
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-112316 Neuronal System 3 R-HSA-1266738 Developmental Biology 3 R-HSA-1640170 Cell Cycle 2 GO:0005634 nucleus 1 R-HSA-1474165 Reproduction 1 R-HSA-5357801 Programmed Cell Death 1 R-HSA-9612973 Autophagy 1
Partners
BRAFDCXDISC1LIS1NDEL1PPM1BTSC2YAP1
Complex memberships
NDEL1/LIS1/DISC1 complexTSC1/TSC2 complex (client)YWHAE-NUTM2 fusion oncoprotein complex

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 14-3-3ε (YWHAE) binds to the microtubule-binding protein doublecortin, preventing its degradation; 14-3-3ε overexpression disrupts neurite formation by preventing microtubule invasion into primitive neurites, and this can be rescued by doublecortin knockdown; 14-3-3ε deficiency increases neurite formation in vitro and in vivo. Co-immunoprecipitation, in vitro binding assays, in vivo mouse (14-3-3ε flox) knockout, live imaging of neurite formation Human molecular genetics High 28173130
2021 The YWHAE-NUTM2 fusion oncoprotein complexes with both BRAF/RAF1 and YAP/TAZ in high-grade endometrial stromal sarcoma (HG-ESS); YWHAE-NUTM2 knockdown inhibits RAF/MEK/MAPK phosphorylation, cyclin D1 expression, and cell proliferation; MEK and CDK4/6 inhibitors have synergistic anti-proliferative effects in HG-ESS. Co-immunoprecipitation, siRNA knockdown, western blotting, pharmacological inhibition assays Oncogenesis High 33947829
2020 14-3-3ε (YWHAE) promotes protein synthesis in multiple myeloma cells by binding to and inhibiting the TSC1/TSC2 complex, and by directly interacting with and promoting phosphorylation of mTORC1; 14-3-3ε depletion reduces protein synthesis by up to 50% including immunoglobulin light chain secretion. Co-immunoprecipitation, siRNA knockdown/overexpression, western blotting, protein synthesis assays, KO cell lines Blood High 32187357
2023 YWHAE/14-3-3ε is crotonylated at lysines K73 and K78 during leucine deprivation; crotonylation releases PPM1B (a phosphatase) from YWHAE, allowing PPM1B to dephosphorylate ULK1 and activate autophagy; decrotonylation of YWHAE is mediated by HDAC7, whose activity is inhibited during leucine deprivation. Mass spectrometry crotonylome profiling, site-directed mutagenesis (K73R/K78R), molecular dynamics simulation, co-immunoprecipitation, western blotting Autophagy High 36628438
2018 YWHAE directly interacts with Helicobacter pylori CagA protein; this interaction promotes CagA-enhanced NF-κB transactivation; YWHAE overexpression augments NF-κB activation by CagA, while YWHAE knockdown inhibits it. Yeast two-hybrid screen, GST pulldown, co-immunoprecipitation, immunolocalization, siRNA knockdown FEMS microbiology letters Medium 29106533
2016 YWHAE (14-3-3ε) acts as a negative regulator of CDC25B and MYC in gastric cancer cells; YWHAE silencing upregulates CDC25B and MYC, leading to increased cell proliferation, invasion, and migration; MYC reciprocally induces CDC25B expression while reducing YWHAE expression. siRNA silencing, overexpression constructs, cell proliferation/invasion/migration assays, in vivo xenograft, qRT-PCR, western blotting Oncotarget Medium 27863420
2024 14-3-3ε/YWHAE negatively regulates cardiac sodium channel NaV1.5 expression: YWHAE binds TBX5 mRNA and decreases its stability, thereby reducing TBX5-mediated transcription of SCN5A; YWHAE knockdown in mice increases sodium current density and causes premature ventricular contractions. RNA immunoprecipitation, western blotting, patch clamp, qRT-PCR, AAV9-mediated in vivo knockdown, ECG recording Heart rhythm High 38750908
2024 ANKZF1 interacts with YWHAE (14-3-3ε) to competitively inhibit YWHAE-driven cytoplasmic retention of YAP1, resulting in YAP1 nuclear import and transcriptional activation of pro-lymphangiogenic factors in clear-cell renal cell carcinoma. Co-immunoprecipitation, mass spectrometry, RNA immunoprecipitation, immunofluorescence, site-specific mutation analyses, RNA sequencing Cancer communications Medium 38407929
2020 14-3-3ε (YWHAE) is essential for male fertility and normal sperm function; testis-specific and global knockout of YWHAE in mice causes infertility, low sperm count, abnormal spermatozoa morphology, and reduced sperm motility; YWHAE KO reduces phosphorylation of GSK3 and PP1γ2 in spermatozoa. Conditional and global knockout mouse models, computer-assisted semen analysis, immunohistochemistry, western blotting for phosphorylation status Andrology High 32657535
2021 YWHAE interacts with HE4 protein in ovarian cancer cells; YWHAE-HE4 interaction mediates downstream AKT and MAPK signaling pathway activation; YWHAE knockdown reduces invasion, migration, proliferation and increases apoptosis. Co-immunoprecipitation, western blotting, immunofluorescence, siRNA knockdown, in vivo xenograft Cancer cell international Medium 34107979
2023 TRIP13 forms a complex with YWHAE in multiple myeloma cells; a small molecule DCZ5417 disrupts the TRIP13/YWHAE complex and inhibits ERK/MAPK signaling, suppressing MM cell proliferation. Molecular docking, pull-down, surface plasmon resonance, cellular thermal shift assay, ATPase assay, co-immunoprecipitation, siRNA/pharmacological approaches Journal of translational medicine Medium 38012658
2019 YWHAE lncRNA acts as a competing endogenous RNA (ceRNA) sponging miR-323a-3p and miR-532-5p, thereby preventing miRNA-mediated suppression of K-Ras, and upregulating K-Ras/Erk1/2 and PI3K/Akt signaling pathways in HCT116 colorectal cancer cells. RNA-seq, RT-qPCR, western blotting, dual luciferase reporter assay, overexpression constructs, wound-healing assay, flow cytometry Human molecular genetics Medium 31238337
2023 YWHAE loss-of-function (heterozygous variants and deletions) in humans causes a neurodevelopmental disorder with corpus callosum hypoplasia, delayed myelination, and ventricular dilatation; Ywhae-/- mice recapitulate brain structural defects including thin cerebral cortex, corpus callosum dysgenesis, and hydrocephalus. Human genetic cohort (SNVs and CNVs), Ywhae knockout mouse neuroanatomical phenotyping, MRI Genetics in medicine High 36999555
2025 METTL3-dependent m6A modification of YWHAE mRNA, recognized by the m6A reader IGF2BP2, enhances YWHAE mRNA stability; YWHAE promotes hepatoblastoma cell proliferation and inhibits ferroptosis by mediating SLC7A11 expression; YWHAE knockdown increases lipid ROS and promotes ferroptosis susceptibility. RNA sequencing, m6A sequencing, RIP, western blotting, in vitro and in vivo functional studies, ROS/peroxide level assays Oncogene Medium 40074884
2023 NKD1 protein binds to the YWHAE gene promoter and transcriptionally activates YWHAE expression in colon cancer cells; NKD1-driven YWHAE upregulation promotes glucose uptake in tumor cells. ChIP assay, dual luciferase reporter assay, RT-qPCR, western blotting, immunofluorescence, siRNA/overexpression in HCT116 and SW620 cells Journal of Southern Medical University Medium 37202194
2008 YWHAE (14-3-3ε) interacts with DISC1, NUDEL, and LIS1 as part of a neurodevelopmental complex; Ywhae+/- mice show reduced 14-3-3ε protein to 50% of wild-type and display defects in working memory and enhanced anxiety-like behavior. Genetic association, Ywhae heterozygous knockout mouse, behavioral testing (eight-arm radial maze, elevated plus-maze), protein expression analysis Human molecular genetics Medium 18658164
2021 14-3-3ε (YWHAE) regulates neuronal migration by binding to NDEL1, an LIS1-interacting protein, positioning YWHAE downstream of LIS1 in the neuronal migration pathway at 17p13.3. Review of genetic epistasis and molecular interaction data from prior studies; framed within 17p13.3 gene function context Brain sciences Low 35053800

Source papers

Stage 0 corpus · 75 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor. The American journal of surgical pathology 204 22456610
2016 Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney. The American journal of surgical pathology 164 26945340
2012 Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement. The American journal of surgical pathology 133 22982899
2009 Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment. Journal of medical genetics 99 19584063
2008 Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Human molecular genetics 87 18658164
2020 NTRK3 overexpression in undifferentiated sarcomas with YWHAE and BCOR genetic alterations. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 64 32034283
2013 YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas: genetic and pathological correlations. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 56 23599159
2016 Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney: not the full story. The Journal of pathology 54 27000436
2013 Frequent expression of KIT in endometrial stromal sarcoma with YWHAE genetic rearrangement. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 52 24186140
2020 Undifferentiated round cell sarcoma with BCOR internal tandem duplications (ITD) or YWHAE fusions: a clinicopathologic and molecular study. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 51 32372022
2016 YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells: new insights about YWHAE role in the tumor development and metastasis process. Oncotarget 42 27863420
2015 BCOR internal tandem duplication and YWHAE-NUTM2B/E fusion are mutually exclusive events in clear cell sarcoma of the kidney. Genes, chromosomes & cancer 41 26493387
2020 High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 38 32317704
2016 Regulation of neuronal morphogenesis by 14-3-3epsilon (Ywhae) via the microtubule binding protein, doublecortin. Human molecular genetics 38 28173130
2009 Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia. Journal of medical genetics 36 19635726
2019 YWHAE promotes proliferation, metastasis, and chemoresistance in breast cancer cells. The Kaohsiung journal of medical sciences 33 31001932
2012 Identification of a rare 17p13.3 duplication including the BHLHA9 and YWHAE genes in a family with developmental delay and behavioural problems. BMC medical genetics 30 23035971
2024 NAT10-mediated ac4C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1. Cancer communications (London, England) 29 38407929
2015 Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 24 26172220
2021 YWHAE-NUTM2 oncoprotein regulates proliferation and cyclin D1 via RAF/MAPK and Hippo pathways. Oncogenesis 23 33947829
2019 YWHAE long non-coding RNA competes with miR-323a-3p and miR-532-5p through activating K-Ras/Erk1/2 and PI3K/Akt signaling pathways in HCT116 cells. Human molecular genetics 23 31238337
2016 Molecular Cytogenetic Analysis of JAZF1, PHF1, and YWHAE in Endometrial Stromal Tumors: Discovery of Genetic Complexity by Fluorescence in Situ Hybridization. The Journal of molecular diagnostics : JMD 23 27154512
2021 YWHAE as an HE4 interacting protein can influence the malignant behaviour of ovarian cancer by regulating the PI3K/AKT and MAPK pathways. Cancer cell international 19 34107979
2013 Breakages at YWHAE, FAM22A, and FAM22B loci in uterine angiosarcoma: a case report with immunohistochemical and genetic analysis. Pathology, research and practice 19 24125656
2022 RNA-Binding Protein COL14A1, TNS1, NUSAP1 and YWHAE Are Valid Biomarkers to Predict Peritoneal Metastasis in Gastric Cancer. Frontiers in oncology 18 35515139
2021 Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3ε). Brain sciences 18 35053800
2020 YWHAE/14-3-3ε expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma. Blood 17 32187357
2014 The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects. Progress in neuro-psychopharmacology & biological psychiatry 17 24561237
2012 Polymorphisms and haplotypes in the YWHAE gene increase susceptibility to bipolar disorder in Chinese Han population. The Journal of clinical psychiatry 17 23140658
2023 Comprehensive analysis of the function of helicobacter-associated ferroptosis gene YWHAE in gastric cancer through multi-omics integration, molecular docking, and machine learning. Apoptosis : an international journal on programmed cell death 16 38001345
2017 Disruption of YWHAE gene at 17p13.3 causes learning disabilities and brain abnormalities. Clinical genetics 15 28542865
2014 The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and brain morphology in schizophrenia: a voxel-based morphometric study. PloS one 15 25105667
2023 YWHAE/14-3-3ε crotonylation regulates leucine deprivation-induced autophagy. Autophagy 14 36628438
2019 YWHAE-NUTM2A/B Translocated High-grade Endometrial Stromal Sarcoma Commonly Expresses CD56 and CD99. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 14 30252726
2021 A translational study: Involvement of miR-21-5p in development and maintenance of neuropathic pain via immune-related targets CCL5 and YWHAE. Experimental neurology 13 34758342
2015 The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney. Genes, chromosomes & cancer 13 26542179
2013 YWHAE/14-3-3ε: a potential novel genetic risk factor and CSF biomarker for HIV neurocognitive impairment. Journal of neurovirology 13 23982958
2020 The protein YWHAE (14-3-3 epsilon) in spermatozoa is essential for male fertility. Andrology 12 32657535
2023 Uterine Endometrial Stromal Tumors With Pure Low-Grade Morphology Harboring YWHAE::NUTM2 Fusions: Report of a Case Series Emphasizing Potential for High-Grade Transformation and Aggressive Behavior. The American journal of surgical pathology 11 37032555
2023 The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13-MAPK-YWHAE signaling pathway. Journal of translational medicine 11 38012658
2017 An Unusual Case of YWHAE-NUTM2A/B Endometrial Stromal Sarcoma With Confinement to the Endometrium and Lack of High-Grade Morphology. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 11 27171540
2016 Normalization of qPCR in platelets - YWHAE a potential genericreference gene. Platelets 11 27232341
2020 17p13.3 microdeletion including YWHAE and CRK genes: towards a clinical characterization. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 10 32323081
2023 YWHAE loss of function causes a rare neurodevelopmental disease with brain abnormalities in human and mouse. Genetics in medicine : official journal of the American College of Medical Genetics 9 36999555
2022 Further expansion and confirmation of phenotype in rare loss of YWHAE gene distinct from Miller-Dieker syndrome. American journal of medical genetics. Part A 9 36433683
2018 YWHAE is a novel interaction partner of Helicobacter pylori CagA. FEMS microbiology letters 9 29106533
2022 miR-29b-3p inhibits 22Rv1 prostate cancer cell proliferation through the YWHAE/BCL-2 regulatory axis. Oncology letters 8 35928803
2021 KRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer. Translational cancer research 8 35116456
2019 Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion. Case reports in oncology 8 31543780
2017 The YWHAE gene confers risk to major depressive disorder in the male group of Chinese Han population. Progress in neuro-psychopharmacology & biological psychiatry 8 28414084
2010 No association of the YWHAE gene with schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population. Behavior genetics 8 21184166
2019 Functional study of 14-3-3 protein epsilon (YWHAE) in keratinocytes: microarray integrating bioinformatics approaches. Journal of biomolecular structure & dynamics 7 31244373
2024 The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small cell lung cancer progression and chemoresistance by mediating autophagy. Functional & integrative genomics 5 38363382
2022 JAZF1, YWHAE and BCOR gene translocation in primary extrauterine low-grade and high-grade endometrial stromal sarcomas. Histopathology 5 34843125
2016 [Endometrial stromal sarcoma: morphologic features and detection of JAZF1-SUZ12 and YWHAE FAM22 fusion genes]. Zhonghua bing li xue za zhi = Chinese journal of pathology 5 27142911
2012 Expression analysis of a 17p terminal deletion, including YWHAE, but not PAFAH1B1, associated with normal brain structure on MRI in a young girl. American journal of medical genetics. Part A 5 22887762
2025 Multi-omics integration reveals YWHAE as a key mediator of ferroptosis in ARDS. Functional & integrative genomics 4 40261442
2024 Exosomes from Intrahepatic Cholestasis of Pregnancy Induce Cell Apoptosis Through the miRNA-6891-5p/YWHAE Pathway. Digestive diseases and sciences 4 38361148
2022 Correction: Liu et al. Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3ε). Brain Sci. 2022, 12, 56. Brain sciences 4 35326370
2017 Uterine epithelioid leiomyosarcoma with c-kit expression and YWHAE gene rearrangement: a case report of a diagnostic pitfall of uterine sarcoma. Diagnostic pathology 4 28288693
2013 [Association of YWHAE gene polymorphism with suicidal behavior]. Genetika 4 24450199
2025 YWHAE affects proliferation, migration and apoptosis of colorectal cancer by regulating extracellular vesicles secretion and Wnt/β-catenin signaling pathway. Translational cancer research 3 40386277
2019 Utility of YWHAE fluorescent in-situ hybridisation in mesenchymal tumors of uterus- An initial experience from tertiary oncology centre in India. Indian journal of cancer 3 31607703
2024 14-3-3ε/YWHAE regulates the transcriptional expression of cardiac sodium channel NaV1.5. Heart rhythm 2 38750908
2023 High-grade endometrial stromal sarcoma with YWHAE-NUTM2B fusion gene abnormality identified after 10 years of recurrent pulmonary metastases: A case report. Gynecologic oncology reports 2 37533428
2022 Genetic variation of YWHAE gene-"Switch" of disease control. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2 35545369
2025 N6-methyadenosine-modified YWHAE mRNA promotes proliferation and inhibits ferroptosis in hepatoblastoma by mediating SLC7A11 expression. Oncogene 1 40074884
2023 [NKD1 promotes glucose uptake in colon cancer cells by activating YWHAE transcription]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 1 37202194
2022 Case Report: An Adolescent Soft Tissue Sarcoma With YWHAE-NUTM2B Fusion Is Effectively Treated With Combined Therapy of Epirubicin and Anlotinib. Frontiers in oncology 1 35814390
2026 [YWHAE-rearranged clear cell sarcoma of kidney: a clinicopathological analysis of seven cases]. Zhonghua bing li xue za zhi = Chinese journal of pathology 0 41644425
2026 An adult patient with pulmonary atresia with ventricular septal defect and chromosome 17p13.3 microdeletion including YWHAE gene. Cardiology in the young 0 41656856
2026 MiR-4261 targeted YWHAE/CAST/GPX1 impairs the calcium regulatory function of PMCA4 in erythrocytes of myeloma. Indian journal of pathology & microbiology 0 41983776
2025 Synergistic epigenetic modulation by 5-aza-2'-deoxycytidine and Wnt3a drives osteogenic trans-differentiation of 3T3-L1 pre-adipocytes through Ywhah and Ywhae. Epigenomics 0 40792537
2025 Congenital Undifferentiated Retroperitoneal Sarcoma With YWHAE::NUTM2B Fusion From the Abdomen to the Brain. Journal of pediatric hematology/oncology 0 41052351
2025 Behavioral analyses of a forebrain glutamatergic neuron specific Ywhae conditional knockout mouse model. PloS one 0 41218078