Affinage

YWHAE

14-3-3 protein epsilon · UniProt P62258

Length
255 aa
Mass
29.2 kDa
Annotated
2026-06-11
75 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

YWHAE encodes 14-3-3ε, a phosphopeptide-binding adaptor that governs cytoskeletal dynamics, growth signaling, and cell-fate decisions across neuronal and proliferative contexts (PMID:28173130, PMID:32187357, PMID:36999555). In developing neurons it binds and stabilizes the microtubule-binding protein doublecortin, restraining microtubule invasion of nascent neurites; loss of 14-3-3ε increases neurite formation, and Ywhae-null mice display cortical thinning, corpus callosum dysgenesis, and hydrocephalus that mirror the neurodevelopmental phenotypes of human patients carrying heterozygous YWHAE loss-of-function variants (PMID:28173130, PMID:36999555). As a signaling adaptor it promotes mTORC1 activity and protein synthesis by binding and inhibiting the TSC1/TSC2 complex, a role essential for the high protein load of multiple myeloma cells (PMID:32187357). Its scaffolding output is tuned by post-translational modification: leucine deprivation drives lysine crotonylation at K73/K78 (reversed by HDAC7), which releases the phosphatase PPM1B to dephosphorylate ULK1 and activate autophagy (PMID:36628438). 14-3-3ε also controls subcellular partitioning of effectors—retaining YAP1 in the cytoplasm—and acts in RNA-level regulation, binding and destabilizing TBX5 mRNA to suppress cardiac SCN5A/NaV1.5 expression and sodium current (PMID:38407929, PMID:38750908). It is required for male fertility, with knockout sperm showing reduced GSK3 and PP1γ2 phosphorylation (PMID:32657535). Oncogenically, the YWHAE-NUTM2 fusion produced by chromosomal translocation complexes with BRAF/RAF1 and YAP/TAZ to drive RAF/MEK/MAPK signaling and cyclin D1–dependent proliferation in high-grade endometrial stromal sarcoma (PMID:33947829).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 2016 High

    Established a concrete cytoskeletal mechanism for 14-3-3ε in neurodevelopment by showing it stabilizes doublecortin to control neurite outgrowth, moving beyond guilt-by-association to a defined binding partner and phenotype.

    Evidence Co-IP, 14-3-3ε flox knockout mice, neurite imaging, and DCX-knockdown rescue

    PMID:28173130

    Open questions at the time
    • Does not define the phospho-site on DCX recognized by 14-3-3ε
    • Relationship to NDEL1/LIS1 pathway not addressed in this study
  2. 2016 Medium

    Addressed whether YWHAE constrains proliferation, finding it negatively regulates CDC25B and MYC in gastric cancer, framing it as a tumor-suppressive node in that context.

    Evidence siRNA knockdown of YWHAE/CDC25B/MYC with proliferation, invasion, migration assays and tumor expression analysis

    PMID:27863420

    Open questions at the time
    • No direct binding assay establishing physical interaction
    • Mechanism of reciprocal MYC–YWHAE regulation undefined
  3. 2018 Medium

    Showed YWHAE is co-opted by a bacterial effector, binding H. pylori CagA to potentiate NF-κB activation, extending its adaptor role to host–pathogen signaling.

    Evidence Yeast two-hybrid, GST pull-down, Co-IP, immunolocalization, NF-κB reporter with OE/KD

    PMID:29106533

    Open questions at the time
    • Binding interface and phospho-dependence not mapped
    • In vivo relevance to infection not tested
  4. 2020 High

    Resolved how 14-3-3ε drives growth signaling, demonstrating it inhibits the TSC1/TSC2 complex and promotes mTORC1 to sustain protein synthesis in myeloma.

    Evidence Co-IP for TSC1/TSC2 and mTORC1, KO/OE with quantitative protein-synthesis and immunoglobulin-secretion readouts and addback rescue

    PMID:32187357

    Open questions at the time
    • Phospho-sites on TSC1/TSC2 mediating the interaction not defined
    • Whether effect generalizes beyond secretory tumor cells unclear
  5. 2020 High

    Defined an isoform-specific physiological requirement, showing Ywhae is essential for spermatogenesis and links to GSK3 and PP1γ2 phosphorylation in sperm.

    Evidence Conditional and global knockout mice, computer-assisted semen analysis, western blot for GSK3/PP1γ2 phosphorylation

    PMID:32657535

    Open questions at the time
    • Direct substrate-binding mechanism for GSK3/PP1γ2 regulation not established
    • Step in spermatogenesis where 14-3-3ε acts not pinpointed
  6. 2021 High

    Established the oncogenic mechanism of the YWHAE-NUTM2 fusion, showing it scaffolds BRAF/RAF1 and YAP/TAZ to drive MAPK signaling and cyclin D1–dependent proliferation, with a synergistic MEK + CDK4/6 inhibitor vulnerability.

    Evidence Reciprocal Co-IP, fusion and cyclin D1 knockdown with phosphorylation/RB1/proliferation readouts, pharmacological inhibition

    PMID:33947829

    Open questions at the time
    • How the fusion alters native 14-3-3ε binding specificity unresolved
    • Relative contributions of RAF/MAPK versus Hippo/YAP arms not dissected
  7. 2021 Medium

    Added a pro-tumorigenic interaction in ovarian cancer via HE4 (WFDC2), linking YWHAE to AKT/MAPK-driven invasion and survival.

    Evidence Co-IP, co-immunofluorescence, OE/KD with invasion/migration/proliferation/apoptosis assays and in vivo work

    PMID:34107979

    Open questions at the time
    • Single Co-IP without reciprocal validation
    • Whether HE4 binding is phospho-dependent unknown
  8. 2022 Medium

    Identified miR-29b-3p as a direct YWHAE 3'UTR repressor controlling the apoptotic balance (BAD/BAX/BCL-2) in prostate cancer.

    Evidence Dual-luciferase 3'UTR assay, miRNA OE, apoptosis-marker westerns, xenograft rescue

    PMID:35928803

    Open questions at the time
    • How YWHAE biochemically modulates BAD phosphorylation not shown
    • Single cell-line context
  9. 2023 High

    Uncovered crotonylation as a metabolic switch on 14-3-3ε, with K73/K78 modification during leucine deprivation releasing PPM1B to dephosphorylate ULK1 and activate autophagy.

    Evidence Crotonylome MS, K73R/K78R mutagenesis, molecular dynamics, ULK1 phosphorylation and PPM1B interaction assays

    PMID:36628438

    Open questions at the time
    • Crotonyl-CoA source and stoichiometry in vivo not quantified
    • Whether modification alters canonical phosphopeptide binding untested
  10. 2023 High

    Confirmed YWHAE haploinsufficiency causes a human neurodevelopmental disorder, with knockout mice recapitulating cortical, callosal, and ventricular defects of patients.

    Evidence Ywhae-/- mouse neuroanatomy and clinical phenotyping of 10 patients with heterozygous loss-of-function variants

    PMID:36999555

    Open questions at the time
    • Molecular pathway linking 14-3-3ε loss to specific structural defects not dissected
    • Genotype–phenotype correlation across variants limited
  11. 2023 Medium

    Placed YWHAE transcriptionally downstream of NKD1 in colon cancer glucose metabolism, with NKD1 directly activating the YWHAE promoter.

    Evidence ChIP, dual-luciferase promoter assay, NKD1 KO with YWHAE-OE rescue of glucose uptake

    PMID:37202194

    Open questions at the time
    • Mechanism by which YWHAE controls glucose uptake undefined
    • Single lab/cell system
  12. 2023 Medium

    Identified the TRIP13/YWHAE complex as a druggable node in myeloma, with the inhibitor DCZ5417 disrupting it to suppress ERK/MAPK signaling.

    Evidence Docking, pull-down, SPR, CETSA, ATPase assay, Co-IP, and genetic/pharmacological epistasis

    PMID:38012658

    Open questions at the time
    • Functional consequence of the TRIP13–YWHAE interaction independent of drug not defined
    • Binding interface unmapped
  13. 2024 High

    Demonstrated a new RNA-regulatory function: 14-3-3ε binds and destabilizes TBX5 mRNA to suppress cardiac SCN5A/NaV1.5 and modulate sodium current and arrhythmia susceptibility.

    Evidence RNA immunoprecipitation, patch clamp, AAV9 knockdown in mice, ECG/echo, TBX5 epistasis

    PMID:38750908

    Open questions at the time
    • Whether 14-3-3ε binds mRNA directly or via an adaptor not resolved
    • Mechanism of mRNA destabilization undefined
  14. 2024 Medium

    Showed YWHAE controls YAP1 cytoplasmic retention competitively, with ANKZF1 binding releasing YAP1 for nuclear pro-lymphangiogenic transcription in renal cancer.

    Evidence Co-IP, RIP, immunofluorescence, MS, site-specific mutagenesis, RNA-seq

    PMID:38407929

    Open questions at the time
    • Phospho-dependence of the YWHAE–YAP1 interaction not detailed
    • Single lab/tumor context
  15. 2024 Medium

    Added miR-873-5p as another direct 3'UTR repressor of YWHAE, linking YWHAE to PI3K/AKT activation and gefitinib resistance in NSCLC.

    Evidence Dual-luciferase, RIP, pathway westerns, proliferation/migration assays with miRNA OE

    PMID:38363382

    Open questions at the time
    • How YWHAE activates PI3K/AKT mechanistically not shown
    • Single cell-line context
  16. 2025 Medium

    Connected YWHAE to ferroptosis regulation, with m6A-driven stabilization (METTL3/IGF2BP2) promoting its expression and knockdown enhancing lipid-ROS and ferroptosis via SLC7A11 downregulation in hepatoblastoma.

    Evidence m6A-seq, m6A-RIP, Co-IP, in vitro/in vivo knockdown, lipid ROS/peroxide assays

    PMID:40074884

    Open questions at the time
    • Direct mechanism linking YWHAE to SLC7A11 not established
    • Single tumor type
  17. 2025 Low

    Reported YWHAE as a suppressor of osteogenic ALP expression in pre-adipocytes, hinting at a mesenchymal cell-fate role.

    Evidence siRNA knockdown in 3T3-L1 cells with ALP activity and transcriptomic/epigenomic profiling

    PMID:40792537

    Open questions at the time
    • Single siRNA knockdown with limited mechanistic depth
    • No direct target identified
    • Not validated in primary mesenchymal precursors
  18. 2025 Low

    Associated YWHAE expression with ferroptotic lung injury in ARDS, where ferrostatin-1 reduced both injury and YWHAE levels.

    Evidence Multi-omics integration, LPS-induced ARDS mouse model, ferroptosis biochemical assays

    PMID:40261442

    Open questions at the time
    • Role inferred from expression changes without direct functional manipulation
    • Causal directionality versus ferroptosis unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single adaptor integrates phosphopeptide binding, crotonylation, mRNA destabilization, and effector sequestration into context-specific outputs—and which interactions are direct versus indirect—remains unresolved.
  • No unifying structural model of partner selectivity across contexts
  • Direct versus adaptor-mediated RNA binding undefined
  • How crotonylation and phosphopeptide binding intersect functionally unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 2 GO:0003723 RNA binding 1 GO:0008092 cytoskeletal protein binding 1
Localization
GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1266738 Developmental Biology 2 R-HSA-1643685 Disease 2 R-HSA-392499 Metabolism of proteins 1 R-HSA-9612973 Autophagy 1
Partners
BRAFDCXPPM1BTRIP13TSC1TSC2WFDC2YAP1
Complex memberships
TRIP13/YWHAE complexTSC1/TSC2 complexYWHAE-NUTM2 fusion oncoprotein complex

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 14-3-3ε (YWHAE) binds to the microtubule-binding protein doublecortin (DCX), preventing its degradation. Overexpression of 14-3-3ε disrupts neurite formation by preventing microtubule invasion into primitive neurites, an effect rescuable by DCX knockdown. Conversely, 14-3-3ε deficiency (flox knockout) increases neurite formation. Co-immunoprecipitation/binding assay, in vitro and in vivo (14-3-3ε flox mice) techniques, neurite formation imaging, rescue by siRNA knockdown Human molecular genetics High 28173130
2021 The YWHAE-NUTM2 fusion oncoprotein complexes with both BRAF/RAF1 and YAP/TAZ in high-grade endometrial stromal sarcoma (HG-ESS). YWHAE-NUTM2 knockdown inhibits RAF/MEK/MAPK phosphorylation, cyclin D1 expression, and cell proliferation. Cyclin D1 knockdown dephosphorylates RB1 and inhibits proliferation. MEK and CDK4/6 inhibitors have synergistic anti-proliferative effects in HG-ESS. Co-immunoprecipitation (BRAF/RAF1 and YAP/TAZ), siRNA knockdown of YWHAE-NUTM2 and cyclin D1 with proliferation/phosphorylation readouts, pharmacological inhibition Oncogenesis High 33947829
2023 YWHAE/14-3-3ε undergoes lysine crotonylation at K73 and K78 during leucine deprivation-induced autophagy. Blocking crotonylation (K73R/K78R mutants) attenuates autophagy. Crotonylation of YWHAE releases PPM1B, which then dephosphorylates ULK1 to activate autophagy. Decrotonylation of YWHAE is mediated by HDAC7, whose activity is inhibited by leucine deprivation. Crotonylome mass spectrometry, site-directed mutagenesis (K73R/K78R), molecular dynamics simulation, biochemical assays for ULK1 phosphorylation and PPM1B interaction Autophagy High 36628438
2020 14-3-3ε (YWHAE) promotes translation initiation and protein synthesis in multiple myeloma cells through binding and inhibition of the TSC1/TSC2 complex, and directly interacts with and promotes phosphorylation of mTORC1. 14-3-3ε depletion reduces protein synthesis by ~50% and decreases immunoglobulin light chain secretion; overexpression or addback restores protein synthesis and protein load. Co-immunoprecipitation (TSC1/TSC2, mTORC1), siRNA knockdown and overexpression with protein synthesis measurement, immunoglobulin secretion assay, knockout with addback Blood High 32187357
2016 YWHAE silencing in gastric cancer cells upregulates CDC25B and MYC expression, leading to increased cell proliferation, invasion, and migration. YWHAE acts as a negative regulator of the cyclin phosphatase CDC25B and the MYC oncogene. Conversely, MYC induces CDC25B and reduces YWHAE expression. siRNA knockdown of YWHAE, CDC25B, and MYC in gastric cancer cell lines; proliferation, invasion, migration assays; expression analysis in cell lines and tumor samples Oncotarget Medium 27863420
2018 YWHAE interacts directly with H. pylori virulence factor CagA. This interaction was identified by yeast two-hybrid screen and validated by GST pull-down, co-immunoprecipitation, and immunolocalization. Overexpression of YWHAE promotes CagA-mediated NF-κB activation; knockdown of YWHAE inhibits NF-κB activation by CagA. GAL4 yeast two-hybrid screen, GST pull-down assay, co-immunoprecipitation, immunolocalization, YWHAE overexpression/knockdown with NF-κB reporter assay FEMS microbiology letters Medium 29106533
2024 ANKZF1 interacts with YWHAE to competitively inhibit YWHAE-driven cytoplasmic retention of YAP1, leading to nuclear import of YAP1 and transcriptional activation of pro-lymphangiogenic factors in clear-cell renal cell carcinoma. Co-immunoprecipitation, RNA immunoprecipitation, immunofluorescence, mass spectrometry, site-specific mutation analyses, RNA sequencing Cancer communications Medium 38407929
2020 14-3-3ε (YWHAE) is essential for male fertility: it is expressed in spermatozoa (unlike 14-3-3η), and testis-specific and global knockout of Ywhae in mice causes infertility with low sperm count, higher sperm abnormalities, and reduced sperm motility. Knockout spermatozoa show reduced phosphorylation of glycogen synthase kinase 3 and PP1γ2. Conditional knockout (CKO) and global knockout (GKO) mouse models, computer-assisted semen analysis, immunohistochemistry, western blot for GSK3 and PP1γ2 phosphorylation Andrology High 32657535
2023 DCZ5417 (a norcantharidin derivative) targets TRIP13 ATPase and disrupts the TRIP13/YWHAE protein complex, thereby inhibiting ERK/MAPK signaling and suppressing multiple myeloma cell proliferation. The anti-myeloma activity depends on TRIP13. Molecular docking, pull-down assay, surface plasmon resonance binding assay, cellular thermal shift assay, ATPase assay, Co-IP for TRIP13/YWHAE complex, genetic and pharmacological epistasis Journal of translational medicine Medium 38012658
2024 14-3-3ε/YWHAE negatively regulates cardiac NaV1.5 expression by binding to and destabilizing TBX5 mRNA (a transcription factor for SCN5A), thereby decreasing SCN5A mRNA levels and sodium current density. YWHAE knockdown in mice (via AAV9) increases SCN5A mRNA and sodium current and leads to shorter R-R intervals and higher prevalence of premature ventricular contractions. Western blotting, patch clamping, RT-PCR, RNA immunoprecipitation (14-3-3ε with TBX5 mRNA), AAV9-mediated YWHAE knockdown in mice, electrocardiogram, echocardiography; TBX5 knockdown epistasis Heart rhythm High 38750908
2025 N6-methyladenosine (m6A) modification of YWHAE mRNA by METTL3, read by IGF2BP2, enhances YWHAE mRNA stability and promotes its expression in hepatoblastoma. YWHAE knockdown increases lipid ROS and peroxides, enhancing ferroptosis susceptibility, partly through downregulation of SLC7A11. m6A sequencing, RNA sequencing, m6A-RIP, co-immunoprecipitation, in vitro and in vivo knockdown studies, lipid ROS/peroxide assay Oncogene Medium 40074884
2023 NKD1 protein binds to the YWHAE gene promoter and activates YWHAE transcription in colon cancer cells. NKD1 overexpression increases YWHAE mRNA and protein; NKD1 knockout reduces both. YWHAE overexpression rescues the glucose uptake deficit caused by NKD1 knockout, placing YWHAE downstream of NKD1 in glucose metabolism regulation. Chromatin immunoprecipitation (ChIP) assay, dual-luciferase reporter assay, RT-qPCR, western blot, immunofluorescence, glucose uptake assay, NKD1 knockout and YWHAE overexpression rescue Journal of Southern Medical University Medium 37202194
2025 Ywhae (14-3-3ε) knockdown in 3T3-L1 pre-adipocytes enhances Alpl (alkaline phosphatase) expression even without DNA demethylation treatment, identifying YWHAE/Ywhae as a suppressor of osteogenic gene expression in mesenchymal precursors. siRNA knockdown in 3T3-L1 cells, ALP activity assay, transcriptomic and epigenomic profiling Epigenomics Low 40792537
2022 miR-29b-3p targets the 3'UTR of YWHAE mRNA (validated by dual luciferase assay) and inhibits YWHAE expression, resulting in decreased p-BAD/BAD ratio and increased BAX/BCL-2 ratio in 22Rv1 prostate cancer cells, promoting apoptosis. YWHAE overexpression reverses the anti-proliferative effects of miR-29b-3p. Dual luciferase reporter assay (miR-29b-3p targeting YWHAE 3'UTR), siRNA/miRNA overexpression, western blot (BAD, BAX, BCL-2, caspase-3), proliferation/apoptosis assays, in vivo xenograft rescue Oncology letters Medium 35928803
2021 YWHAE interacts with HE4 (WFDC2) in ovarian cancer cells, as demonstrated by co-immunoprecipitation and co-immunofluorescence. YWHAE overexpression enhances invasion, migration, and proliferation while inhibiting apoptosis of ovarian cancer cells through the AKT and MAPK signaling pathways. Co-immunoprecipitation, western blot, cellular immunofluorescence, YWHAE overexpression/knockdown with invasion/migration/proliferation/apoptosis assays, in vivo experiments Cancer cell international Medium 34107979
2024 miR-873-5p directly targets YWHAE 3'UTR (validated by dual-luciferase assay and RIP), suppressing YWHAE expression and inhibiting NSCLC cell proliferation, migration, invasion, and EMT. YWHAE promotes PI3K/AKT pathway activation; miR-873-5p overexpression inhibits the YWHAE-mediated PI3K/AKT signaling cascade and reverses gefitinib resistance by inducing autophagy. Dual-luciferase reporter assay, RNA immunoprecipitation (RIP), western blot (YWHAE, PI3K, AKT), CCK8, colony formation, Transwell, miR-873-5p overexpression Functional & integrative genomics Medium 38363382
2023 Ywhae (14-3-3ε) knockout mice show brain structural defects including thin cerebral cortex, corpus callosum dysgenesis, and hydrocephalus, paralleling neurodevelopmental brain abnormalities seen in human patients with YWHAE loss-of-function variants. Ywhae-/- mouse knockout, neuroanatomical studies (histology, brain imaging), clinical phenotyping of 10 human patients with heterozygous YWHAE loss-of-function variants Genetics in medicine High 36999555
2025 YWHAE is identified as a ferroptosis-associated gene upregulated in ARDS. In an LPS-induced ARDS mouse model, the ferroptosis inhibitor ferrostatin-1 attenuates lung injury and downregulates YWHAE expression, suggesting YWHAE expression is linked to ferroptotic cell death pathways. Multi-omics (proteomics, metabolomics, transcriptomics) integration, LPS-induced ARDS mouse model, western blotting, ferroptosis-related biochemical assays (ROS, lipid peroxidation) Functional & integrative genomics Low 40261442

Source papers

Stage 0 corpus · 75 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor. The American journal of surgical pathology 205 22456610
2016 Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney. The American journal of surgical pathology 169 26945340
2012 Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement. The American journal of surgical pathology 134 22982899
2009 Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment. Journal of medical genetics 100 19584063
2008 Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Human molecular genetics 88 18658164
2020 NTRK3 overexpression in undifferentiated sarcomas with YWHAE and BCOR genetic alterations. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 65 32034283
2020 Undifferentiated round cell sarcoma with BCOR internal tandem duplications (ITD) or YWHAE fusions: a clinicopathologic and molecular study. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 56 32372022
2016 Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney: not the full story. The Journal of pathology 56 27000436
2013 YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas: genetic and pathological correlations. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 56 23599159
2013 Frequent expression of KIT in endometrial stromal sarcoma with YWHAE genetic rearrangement. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 52 24186140
2016 YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells: new insights about YWHAE role in the tumor development and metastasis process. Oncotarget 42 27863420
2015 BCOR internal tandem duplication and YWHAE-NUTM2B/E fusion are mutually exclusive events in clear cell sarcoma of the kidney. Genes, chromosomes & cancer 41 26493387
2020 High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 39 32317704
2016 Regulation of neuronal morphogenesis by 14-3-3epsilon (Ywhae) via the microtubule binding protein, doublecortin. Human molecular genetics 39 28173130
2009 Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia. Journal of medical genetics 36 19635726
2019 YWHAE promotes proliferation, metastasis, and chemoresistance in breast cancer cells. The Kaohsiung journal of medical sciences 34 31001932
2024 NAT10-mediated ac4C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1. Cancer communications (London, England) 32 38407929
2012 Identification of a rare 17p13.3 duplication including the BHLHA9 and YWHAE genes in a family with developmental delay and behavioural problems. BMC medical genetics 30 23035971
2021 YWHAE-NUTM2 oncoprotein regulates proliferation and cyclin D1 via RAF/MAPK and Hippo pathways. Oncogenesis 25 33947829
2019 YWHAE long non-coding RNA competes with miR-323a-3p and miR-532-5p through activating K-Ras/Erk1/2 and PI3K/Akt signaling pathways in HCT116 cells. Human molecular genetics 24 31238337
2015 Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 24 26172220
2016 Molecular Cytogenetic Analysis of JAZF1, PHF1, and YWHAE in Endometrial Stromal Tumors: Discovery of Genetic Complexity by Fluorescence in Situ Hybridization. The Journal of molecular diagnostics : JMD 23 27154512
2023 Comprehensive analysis of the function of helicobacter-associated ferroptosis gene YWHAE in gastric cancer through multi-omics integration, molecular docking, and machine learning. Apoptosis : an international journal on programmed cell death 20 38001345
2022 RNA-Binding Protein COL14A1, TNS1, NUSAP1 and YWHAE Are Valid Biomarkers to Predict Peritoneal Metastasis in Gastric Cancer. Frontiers in oncology 20 35515139
2021 YWHAE as an HE4 interacting protein can influence the malignant behaviour of ovarian cancer by regulating the PI3K/AKT and MAPK pathways. Cancer cell international 20 34107979
2021 Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3ε). Brain sciences 20 35053800
2013 Breakages at YWHAE, FAM22A, and FAM22B loci in uterine angiosarcoma: a case report with immunohistochemical and genetic analysis. Pathology, research and practice 19 24125656
2020 YWHAE/14-3-3ε expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma. Blood 18 32187357
2014 The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects. Progress in neuro-psychopharmacology & biological psychiatry 17 24561237
2012 Polymorphisms and haplotypes in the YWHAE gene increase susceptibility to bipolar disorder in Chinese Han population. The Journal of clinical psychiatry 17 23140658
2017 Disruption of YWHAE gene at 17p13.3 causes learning disabilities and brain abnormalities. Clinical genetics 16 28542865
2023 YWHAE/14-3-3ε crotonylation regulates leucine deprivation-induced autophagy. Autophagy 15 36628438
2014 The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and brain morphology in schizophrenia: a voxel-based morphometric study. PloS one 15 25105667
2021 A translational study: Involvement of miR-21-5p in development and maintenance of neuropathic pain via immune-related targets CCL5 and YWHAE. Experimental neurology 14 34758342
2019 YWHAE-NUTM2A/B Translocated High-grade Endometrial Stromal Sarcoma Commonly Expresses CD56 and CD99. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 14 30252726
2015 The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney. Genes, chromosomes & cancer 14 26542179
2013 YWHAE/14-3-3ε: a potential novel genetic risk factor and CSF biomarker for HIV neurocognitive impairment. Journal of neurovirology 14 23982958
2020 The protein YWHAE (14-3-3 epsilon) in spermatozoa is essential for male fertility. Andrology 12 32657535
2023 YWHAE loss of function causes a rare neurodevelopmental disease with brain abnormalities in human and mouse. Genetics in medicine : official journal of the American College of Medical Genetics 11 36999555
2023 Uterine Endometrial Stromal Tumors With Pure Low-Grade Morphology Harboring YWHAE::NUTM2 Fusions: Report of a Case Series Emphasizing Potential for High-Grade Transformation and Aggressive Behavior. The American journal of surgical pathology 11 37032555
2023 The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13-MAPK-YWHAE signaling pathway. Journal of translational medicine 11 38012658
2020 17p13.3 microdeletion including YWHAE and CRK genes: towards a clinical characterization. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 11 32323081
2017 An Unusual Case of YWHAE-NUTM2A/B Endometrial Stromal Sarcoma With Confinement to the Endometrium and Lack of High-Grade Morphology. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 11 27171540
2016 Normalization of qPCR in platelets - YWHAE a potential genericreference gene. Platelets 11 27232341
2022 Further expansion and confirmation of phenotype in rare loss of YWHAE gene distinct from Miller-Dieker syndrome. American journal of medical genetics. Part A 9 36433683
2021 KRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer. Translational cancer research 9 35116456
2019 Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion. Case reports in oncology 9 31543780
2018 YWHAE is a novel interaction partner of Helicobacter pylori CagA. FEMS microbiology letters 9 29106533
2022 miR-29b-3p inhibits 22Rv1 prostate cancer cell proliferation through the YWHAE/BCL-2 regulatory axis. Oncology letters 8 35928803
2017 The YWHAE gene confers risk to major depressive disorder in the male group of Chinese Han population. Progress in neuro-psychopharmacology & biological psychiatry 8 28414084
2010 No association of the YWHAE gene with schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population. Behavior genetics 8 21184166
2024 The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small cell lung cancer progression and chemoresistance by mediating autophagy. Functional & integrative genomics 7 38363382
2019 Functional study of 14-3-3 protein epsilon (YWHAE) in keratinocytes: microarray integrating bioinformatics approaches. Journal of biomolecular structure & dynamics 7 31244373
2024 Exosomes from Intrahepatic Cholestasis of Pregnancy Induce Cell Apoptosis Through the miRNA-6891-5p/YWHAE Pathway. Digestive diseases and sciences 5 38361148
2022 JAZF1, YWHAE and BCOR gene translocation in primary extrauterine low-grade and high-grade endometrial stromal sarcomas. Histopathology 5 34843125
2016 [Endometrial stromal sarcoma: morphologic features and detection of JAZF1-SUZ12 and YWHAE FAM22 fusion genes]. Zhonghua bing li xue za zhi = Chinese journal of pathology 5 27142911
2012 Expression analysis of a 17p terminal deletion, including YWHAE, but not PAFAH1B1, associated with normal brain structure on MRI in a young girl. American journal of medical genetics. Part A 5 22887762
2025 Multi-omics integration reveals YWHAE as a key mediator of ferroptosis in ARDS. Functional & integrative genomics 4 40261442
2022 Correction: Liu et al. Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3ε). Brain Sci. 2022, 12, 56. Brain sciences 4 35326370
2017 Uterine epithelioid leiomyosarcoma with c-kit expression and YWHAE gene rearrangement: a case report of a diagnostic pitfall of uterine sarcoma. Diagnostic pathology 4 28288693
2013 [Association of YWHAE gene polymorphism with suicidal behavior]. Genetika 4 24450199
2025 YWHAE affects proliferation, migration and apoptosis of colorectal cancer by regulating extracellular vesicles secretion and Wnt/β-catenin signaling pathway. Translational cancer research 3 40386277
2022 Genetic variation of YWHAE gene-"Switch" of disease control. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 3 35545369
2019 Utility of YWHAE fluorescent in-situ hybridisation in mesenchymal tumors of uterus- An initial experience from tertiary oncology centre in India. Indian journal of cancer 3 31607703
2025 N6-methyadenosine-modified YWHAE mRNA promotes proliferation and inhibits ferroptosis in hepatoblastoma by mediating SLC7A11 expression. Oncogene 2 40074884
2024 14-3-3ε/YWHAE regulates the transcriptional expression of cardiac sodium channel NaV1.5. Heart rhythm 2 38750908
2023 High-grade endometrial stromal sarcoma with YWHAE-NUTM2B fusion gene abnormality identified after 10 years of recurrent pulmonary metastases: A case report. Gynecologic oncology reports 2 37533428
2025 Behavioral analyses of a forebrain glutamatergic neuron specific Ywhae conditional knockout mouse model. PloS one 1 41218078
2023 [NKD1 promotes glucose uptake in colon cancer cells by activating YWHAE transcription]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 1 37202194
2022 Case Report: An Adolescent Soft Tissue Sarcoma With YWHAE-NUTM2B Fusion Is Effectively Treated With Combined Therapy of Epirubicin and Anlotinib. Frontiers in oncology 1 35814390
2026 [YWHAE-rearranged clear cell sarcoma of kidney: a clinicopathological analysis of seven cases]. Zhonghua bing li xue za zhi = Chinese journal of pathology 0 41644425
2026 An adult patient with pulmonary atresia with ventricular septal defect and chromosome 17p13.3 microdeletion including YWHAE gene. Cardiology in the young 0 41656856
2026 MiR-4261 targeted YWHAE/CAST/GPX1 impairs the calcium regulatory function of PMCA4 in erythrocytes of myeloma. Indian journal of pathology & microbiology 0 41983776
2025 Synergistic epigenetic modulation by 5-aza-2'-deoxycytidine and Wnt3a drives osteogenic trans-differentiation of 3T3-L1 pre-adipocytes through Ywhah and Ywhae. Epigenomics 0 40792537
2025 Congenital Undifferentiated Retroperitoneal Sarcoma With YWHAE::NUTM2B Fusion From the Abdomen to the Brain. Journal of pediatric hematology/oncology 0 41052351

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