Affinage

PPM1B

Protein phosphatase 1B · UniProt O75688

Length
479 aa
Mass
52.6 kDa
Annotated
2026-04-28
36 papers in source corpus 20 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PPM1B is a Mg²⁺/Mn²⁺-dependent PP2C-family serine/threonine phosphatase that functions as a broad negative regulator of stress-activated, inflammatory, and cell-death signaling by dephosphorylating diverse substrates including IKKβ (Ser177/181, terminating NF-κB signaling), TBK1 (Ser172, attenuating type I interferon responses), RIP3 (Thr231/Ser232, suppressing necroptosis), ULK1 (initiating autophagy), PPARγ (Ser112, promoting adipogenic transcription), DYRK1A (Ser258, reducing tau phosphorylation), and CDK2 (PMID:9684878, PMID:18930133, PMID:22750291, PMID:25751141, PMID:23320500, PMID:33380426, PMID:36543144, PMID:39979355). Substrate specificity is governed by N-myristoylation at Gly2, which directs membrane association and AMPK recognition, and by regulatory subunit association, as exemplified by GAS41, which redirects PPM1B toward p53-Ser366 (PMID:23088624, PMID:21317290). PPM1B protein levels are controlled by PKA-mediated Ser195 phosphorylation triggering proteasomal degradation, by the Cul4A-DDB1-DCAF4L2 and TRIM25 E3 ubiquitin ligases, and by BRISC complex-mediated K63-linked deubiquitination at Lys326; sequestration by 14-3-3ε provides an additional layer of regulation that is relieved by leucine-deprivation-induced crotonylation (PMID:23756813, PMID:27158335, PMID:39979355, PMID:39742393, PMID:36543144). PPM1B also participates in chromatin-level gene regulation by dephosphorylating the Pax2 activation domain within a Groucho4 repressor complex, displacing PTIP and inhibiting H3K4 methylation (PMID:25631048).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1998 High

    Establishing that PPM1B is a bona fide PP2C-family phosphatase resolved its catalytic identity: recombinant PPM1B required Mg²⁺/Mn²⁺ for activity and was insensitive to okadaic acid, distinguishing it from PP1/PP2A-family phosphatases.

    Evidence Recombinant E. coli-expressed protein, in vitro phosphatase assay with divalent cation dependence and okadaic acid insensitivity

    PMID:9684878

    Open questions at the time
    • No physiological substrate identified at this stage
    • Crystal structure not determined in this study
  2. 2008 High

    Identifying IKKβ as a direct PPM1B substrate placed PPM1B as a terminator of NF-κB signaling, answering how TNFα-induced IKKβ activation is shut off.

    Evidence Functional genomic screen, Co-IP of endogenous PPM1B–IKKβ, siRNA knockdown with NF-κB luciferase reporter and phospho-IKKβ immunoblotting

    PMID:18930133

    Open questions at the time
    • In vitro reconstitution of IKKβ dephosphorylation not shown in this study
    • Mechanism of transient recruitment to IKKβ unclear
  3. 2011 High

    Discovery that GAS41 functions as a regulatory subunit directing PPM1B to p53-Ser366 revealed that PPM1B substrate selectivity can be conferred by associated proteins, not just intrinsic catalytic preferences.

    Evidence Co-IP of GAS41–PPM1B complex, in vitro dephosphorylation assay showing PPM1B alone cannot target p53-Ser366, UV survival assay

    PMID:21317290

    Open questions at the time
    • Structural basis of GAS41-mediated substrate recognition unknown
    • Whether other regulatory subunits similarly redirect PPM1B not tested
  4. 2012 High

    Demonstrating that PPM1B dephosphorylates TBK1-Ser172 extended PPM1B's role from NF-κB to innate antiviral signaling, showing it attenuates IRF3 activation and IFNβ production during viral infection.

    Evidence In vitro phosphatase assay, catalytic-dead R179G mutant, Co-IP, IRF3 phosphorylation and IFNβ reporter assays

    PMID:22750291

    Open questions at the time
    • Whether PPM1B regulation changes during chronic versus acute infection not addressed
    • Identity of upstream signal triggering PPM1B–TBK1 association unclear
  5. 2013 High

    Three studies collectively revealed that N-myristoylation controls PPM1B membrane targeting and AMPK substrate recognition, that PPM1B dephosphorylates PPARγ-Ser112 in adipocyte nuclei to promote lipogenic transcription, and that PKA phosphorylation of Ser195 destabilizes PPM1B through ubiquitin-dependent degradation — together establishing that PPM1B activity is tightly regulated at the levels of localization, substrate access, and protein turnover.

    Evidence G2A mutagenesis with in vitro AMPK dephosphorylation and fractionation; IP-MS and nuclear immunofluorescence with PPARγ dephosphorylation and transcriptional reporter; S195A mutagenesis and PKA/proteasome inhibitors with ubiquitination assays

    PMID:23088624 PMID:23320500 PMID:23756813

    Open questions at the time
    • E3 ligase responsible for PKA-stimulated degradation not identified in 2013 study
    • Whether myristoylation affects substrates beyond AMPK not systematically tested
  6. 2014 Medium

    PPM1B depletion was shown to induce premature senescence in human fibroblasts through p38 MAPK, broadening its functional scope beyond inflammatory signaling to cellular aging.

    Evidence Lentiviral shRNA knockdown in IMR-90 cells, SA-β-galactosidase staining, p38 inhibitor rescue

    PMID:24674756

    Open questions at the time
    • Direct p38 dephosphorylation by PPM1B not demonstrated
    • Mechanism linking PPM1B loss to p38 activation unclear — may be indirect
  7. 2015 High

    Two studies established that PPM1B suppresses necroptosis by dephosphorylating RIP3-Thr231/Ser232 (confirmed in Ppm1b-deficient mice) and participates in chromatin-level gene repression by dephosphorylating Pax2 within a Groucho4 complex to inhibit H3K4 methylation.

    Evidence In vitro dephosphorylation, Ppm1b-deficient mouse model with TNF-induced death and RIP3 epistasis; Co-IP of Pax2–PPM1B–Groucho4, ChIP showing H3K4me loss, PPM1B knockdown rescue

    PMID:25631048 PMID:25751141

    Open questions at the time
    • Whether PPM1B targets other necrosome components not tested
    • In vivo role of PPM1B–Groucho4 interaction in development not explored
  8. 2016 Medium

    Identification of Cul4A-DDB1-DCAF4L2 as the E3 ligase complex degrading PPM1B explained one mechanism by which NF-κB signaling is sustained in colorectal cancer.

    Evidence Mass spectrometry identification of E3 complex, Co-IP, knockdown rescue, invasion assays

    PMID:27158335

    Open questions at the time
    • Relationship to PKA-mediated Ser195 phosphorylation-triggered degradation not clarified
    • Whether DCAF4L2 recognizes phosphorylated or unmodified PPM1B unclear
  9. 2020 Medium

    Development of the chemical inhibitor HN252 (Ki = 0.52 µM) and phosphoproteomic profiling identified 30 candidate PPM1B substrates including CDK2, AKT1, HSP90B, β-catenin, and BRCA1, greatly expanding the known substrate repertoire.

    Evidence In vitro phosphatase inhibition assay, phosphoproteomics upon HN252 treatment, Co-IP validation of five substrates

    PMID:33048454

    Open questions at the time
    • In vitro dephosphorylation of most candidates not reconstituted
    • Selectivity of HN252 for PPM1B versus other PP2C family members not fully characterized
  10. 2021 High

    PPM1B was found to dephosphorylate DYRK1A-Ser258, inhibiting its kinase activity and thereby reducing tau phosphorylation and aggregation, connecting PPM1B to neurodegeneration-relevant pathways.

    Evidence LC-MS/MS interactome, Co-IP, in vitro phosphatase assay, tau phosphorylation and aggregation readouts in HEK293 cells

    PMID:33380426

    Open questions at the time
    • Not validated in neuronal cells or animal models of tauopathy
    • Whether PPM1B levels change during neurodegeneration not tested
  11. 2022 High

    The discovery that leucine deprivation triggers 14-3-3ε crotonylation to release sequestered PPM1B, which then dephosphorylates ULK1 to initiate autophagy, revealed a nutrient-sensing mechanism controlling PPM1B activity.

    Evidence Crotonylome MS, molecular dynamics, Co-IP, crotonylation-deficient 14-3-3ε mutant, ULK1 phosphorylation and autophagy flux assays

    PMID:36543144

    Open questions at the time
    • ULK1 dephosphorylation site not mapped
    • Whether this mechanism operates in vivo under physiological fasting not shown
  12. 2023 Medium

    TXLNA was identified as a competitive inhibitor of PPM1B access to TBK1, explaining how aberrant TBK1 activation is maintained in certain cancers despite PPM1B expression.

    Evidence BioID and APEX2 proximity labeling, Co-IP, phospho-TBK1-Ser172 immunoblotting

    PMID:37506885

    Open questions at the time
    • Direct structural basis for TXLNA–TBK1 competition with PPM1B not resolved
    • In vivo relevance in tumor models not demonstrated
  13. 2024 Medium

    PPM1B dephosphorylation of YBX1 at Ser314 was shown to reduce YBX1 stability by impairing USP10-mediated deubiquitination, linking PPM1B to cell death regulation (PANoptosis) and drug resistance in gastric cancer.

    Evidence Co-IP, S314 mutagenesis, ubiquitination assay, cell death assays in gastric cancer cells

    PMID:38364962

    Open questions at the time
    • In vitro reconstitution of PPM1B dephosphorylation of YBX1 not shown
    • Single-lab finding not independently replicated
  14. 2025 High

    Multiple 2025 studies defined new regulatory layers: BRISC complex-mediated K63-linked deubiquitination of PPM1B at Lys326 (modulated by YAP-dependent LLPS) protects PPM1B and suppresses arterial stiffness via TGF-β–Smad signaling; TRIM25 promotes PPM1B degradation activating CDK2 in gastric cancer; and a PPM1B/MP/PRMT5 axis was proposed in lung cancer.

    Evidence GST pulldown, MS, smooth muscle-specific KO mice with Doppler ultrasound (BRISC); Co-IP, ubiquitination assay, xenograft models (TRIM25); correlative IHC and phosphoprotein analysis in patient tissues (PRMT5 axis)

    PMID:39742393 PMID:39979355 PMID:41301499

    Open questions at the time
    • LLPS mechanism for ABRO1–YAP–PPM1B condensate formation requires structural characterization
    • PPM1B/PRMT5 axis based on correlative tissue data; direct dephosphorylation of MYPT1 or PRMT5 by PPM1B not reconstituted in vitro
    • Whether TRIM25-mediated degradation intersects with Cul4A-DDB1-DCAF4L2 pathway unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis for PPM1B's broad substrate recognition, how multiple E3 ligases and deubiquitinases are coordinated to control PPM1B levels in specific tissues, and whether PPM1B mutations contribute to human Mendelian disease.
  • No crystal structure with a physiological substrate or regulatory subunit
  • Systematic comparison of PPM1B versus PPM1A substrate selectivity lacking
  • No human genetic disease linked to PPM1B loss-of-function mutations reported

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 11
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-168256 Immune System 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-8953897 Cellular responses to stimuli 2 R-HSA-1640170 Cell Cycle 1 R-HSA-5357801 Programmed Cell Death 1 R-HSA-9612973 Autophagy 1
Partners
DYRK1AGAS41IKKΒPPARΓRIP3TBK1ULK1YBX1
Complex memberships
GAS41-PPM1B complexPax2-Groucho4-PPM1B repressor complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2015 PPM1B (Ppm1b) directly dephosphorylates RIP3 (Rip3) at Thr231 and Ser232, preventing recruitment of MLKL to the necrosome and thereby suppressing necroptosis both in cultured cells and in vivo. Ppm1b-deficient mice showed enhanced TNF-induced death with elevated Rip3 phosphorylation, confirming the pathway position. Co-immunoprecipitation, in vitro dephosphorylation assay, loss-of-function mouse model (Ppm1b^d/d), phospho-specific immunoblotting, genetic epistasis with Rip3 Nature cell biology High 25751141
2008 PPM1B dephosphorylates IKKβ at Ser177 and Ser181, terminating TNFα-induced IKKβ-NF-κB activation. PPM1B associates with phosphorylated IKKβ transiently after TNFα stimulation; knockdown enhances IKKβ phosphorylation and NF-κB nuclear translocation. Functional genomic screen, overexpression, co-immunoprecipitation, knockdown (siRNA), NF-κB luciferase reporter, immunoblotting Cellular signalling High 18930133
2012 PPM1B dephosphorylates TBK1 at Ser172 in vitro and in vivo. Viral infection transiently induces PPM1B-TBK1 association; phosphatase-dead R179G mutant of PPM1B fails to inhibit TBK1-mediated antiviral response. PPM1B knockdown enhances IRF3 phosphorylation and IFNβ production. In vitro dephosphorylation assay, co-immunoprecipitation, active-site mutagenesis (R179G), knockdown, IRF3 phosphorylation assay, IFNβ reporter Cellular signalling High 22750291
2013 PPM1B (and PPM1A) are N-myristoylated at Gly2, and this modification is essential for dephosphorylation of AMPKα in cells. Non-myristoylated G2A mutant loses membrane association and shows decreased activity toward AMPKα in vitro despite higher activity toward the artificial substrate PNPP, indicating that N-myristoylation controls substrate recognition. Mutagenesis (G2A), in vitro phosphatase assay (AMPKα and PNPP substrates), cell fractionation, metabolic labeling The Biochemical journal High 23088624
2013 PPM1B directly dephosphorylates PPARγ at Ser112 both in intact cells and in vitro, and this dephosphorylation increases PPARγ-mediated transcription. Endogenous PPM1B localizes to the nucleus of mature 3T3-L1 adipocytes where it binds PPARγ. PPM1B knockdown blunts a subset of PPARγ target gene expression. Immunoprecipitation coupled to tandem MS, in vitro dephosphorylation assay, immunofluorescence (nuclear localization), siRNA knockdown, transcriptional reporter assay The Biochemical journal High 23320500
2011 The GAS41-PPM1B complex specifically dephosphorylates p53 at Ser366; PPM1B alone is insufficient for this substrate specificity. GAS41 acts as a regulatory subunit that directs PPM1B substrate recognition. Ectopic GAS41 and PPM1B together reduce UV-induced p53 stabilization and increase cell survival. Co-immunoprecipitation, in vitro dephosphorylation assay, overexpression/knockdown, cell survival assay, phospho-p53 immunoblotting The Journal of biological chemistry High 21317290
2015 PPM1B is an essential component of the Groucho4 repressor complex recruited by Pax2 to chromatin. PPM1B dephosphorylates the Pax2 activation domain and displaces the adaptor PTIP, inhibiting H3K4 methylation and switching Pax2 from a transcriptional activator to a repressor. Loss of PPM1B prevents Groucho-mediated gene repression. Co-immunoprecipitation (Pax2-PPM1B-Groucho4 complex), chromatin immunoprecipitation, in vitro dephosphorylation assay, loss-of-function (PPM1B knockdown), histone methylation analysis The Journal of biological chemistry High 25631048
2012 PPM1B (Ppm1b) interacts with EKLF/KLF1 via the EKLF PEST1 sequence, and this interaction requires intact PPM1B phosphatase activity to superactivate EKLF at the β-globin and BKLF promoters. Conversely, depletion of Ppm1b in CD34+ cells leads to higher endogenous β-globin gene activation after differentiation, indicating a complex regulatory role. Co-immunoprecipitation, promoter-reporter assay (phosphatase-activity-dependent), siRNA knockdown in CD34+ cells, erythroid differentiation assay The Journal of biological chemistry Medium 22393050
2013 PKA phosphorylates PPM1B (PP2Cβ) at Ser195, destabilizing it via ubiquitin-dependent proteasomal degradation and thereby activating NF-κB inflammatory signaling. Mutation of Ser195 and PKA inhibition prevent Forskolin-induced PP2Cβ destabilization. Site-directed mutagenesis (Ser195Ala), PKA inhibitor (H89), proteasomal inhibitor, immunoblotting for ubiquitination and protein stability Biochemical and biophysical research communications Medium 23756813
2021 PPM1B dephosphorylates DYRK1A at Ser258 (an autophosphorylation site), inhibiting DYRK1A kinase activity. PPM1B-mediated reduction of DYRK1A activity leads to decreased tau phosphorylation at Thr212 and inhibition of toxic tau oligomerization and aggregation. LC-MS/MS (DYRK1A interactome in HEK293 cells), co-immunoprecipitation, in vitro phosphatase assay, tau phosphorylation immunoblotting, tau aggregation assay The Journal of biological chemistry High 33380426
2022 Leucine deprivation induces crotonylation of 14-3-3ε, which disrupts the 14-3-3ε amphipathic pocket and releases PPM1B from the 14-3-3ε complex. Free PPM1B then dephosphorylates ULK1, initiating autophagy. This 14-3-3ε-PPM1B axis is regulated by HDAC7. Crotonylome mass spectrometry, molecular dynamics simulation, co-immunoprecipitation, crotonylation-deficient mutant expression, ULK1 phosphorylation assay, autophagy flux assay Cell reports High 36543144
2024 PPM1B directly interacts with YBX1 and dephosphorylates YBX1 at Ser314. This dephosphorylation affects USP10-mediated deubiquitination of YBX1, reducing YBX1 protein levels and impacting PANoptosis and oxaliplatin resistance in gastric cancer cells. Co-immunoprecipitation, phosphorylation site mutagenesis (S314), overexpression/silencing, ubiquitination assay, cell death assays Cancer letters Medium 38364962
2016 PPM1B is a substrate of the Cul4A-DDB1-DCAF4L2 E3 ubiquitin ligase complex; DCAF4L2 overexpression promotes PPM1B proteasomal degradation, thereby activating NF-κB signaling and promoting colorectal cancer invasion. Mass spectrometry (E3 complex identification), co-immunoprecipitation, knockdown rescue experiments, invasion assays American journal of translational research Medium 27158335
2023 TXLNA interacts with TBK1 at its α-helical scaffold and impairs the binding of PPM1B to TBK1, inhibiting PPM1B-mediated dephosphorylation of TBK1-Ser172 and contributing to aberrant TBK1 activation in cancer cells. BioID biotinylation proteomics, APEX2 proximity labeling proteomics, co-immunoprecipitation, TBK1 phosphorylation (S172) immunoblotting Biochimica et biophysica acta. Molecular cell research Medium 37506885
2020 HN252, a p-terphenyl derivative, was identified as a potent PPM1B inhibitor (Ki = 0.52 µM). Using HN252, 30 candidate PPM1B substrates were identified by phosphoproteomic analysis, and five (CDK2, AKT1, HSP90B, β-catenin, BRCA1) were confirmed by immunoprecipitation. In vitro phosphatase inhibition assay (Ki determination), phosphoproteomics with PPM1B inhibitor, co-immunoprecipitation for substrate validation Journal of cellular and molecular medicine Medium 33048454
2014 PPM1B depletion in IMR-90 human fibroblasts induces premature senescence, as evidenced by growth arrest and senescence marker expression. This senescence is partially rescued by p38 MAPK inactivation, placing PPM1B upstream of p38 MAPK in a senescence pathway. Lentiviral shRNA knockdown, SA-β-galactosidase assay, growth arrest quantification, p38 MAPK inhibitor rescue, immunoblotting Mechanisms of ageing and development Medium 24674756
2025 TRIM25 physically interacts with PPM1B and promotes its ubiquitin-dependent degradation, which leads to increased CDK2 phosphorylation and enhanced gastric cancer cell growth. PPM1B overexpression inhibits CDK2 activity and induces G1-phase cell cycle arrest. Co-immunoprecipitation, ubiquitination assay, CDK2 phosphorylation immunoblotting, cell cycle analysis, gain/loss-of-function in cell and xenograft models Scientific reports Medium 39979355
2025 BRISC complex component ABRO1 directly binds YAP and undergoes liquid-liquid phase separation with YAP and PPM1B in a YAP-dependent manner, promoting K63-linked deubiquitination of PPM1B at Lys326. Smooth muscle cell-specific PPM1B overexpression attenuates high-fat/high-sucrose diet-induced arterial stiffness dependent on this K63-linked polyubiquitination. Loss of PPM1B K63 deubiquitination activates TGF-β-Smad signaling. siRNA screening, mass spectrometry, GST pulldown, co-immunoprecipitation, protein purification, immunofluorescence, Doppler ultrasound in mice, smooth muscle cell-specific knockouts (Abro1, Brcc3) Circulation research High 39742393
1998 Recombinant human PP2Cβ (PPM1B) expressed in E. coli shows metal ion (Mg2+/Mn2+)-dependent phosphatase activity and is insensitive to okadaic acid, establishing it as a PP2C-family phosphatase. Recombinant protein expression, in vitro phosphatase assay with cation dependence, okadaic acid insensitivity test FEBS letters High 9684878
2025 Decreased PPM1B expression in lung cancer leads to impaired myosin phosphatase (MP/MYPT1) activity (elevated inhibitory phospho-Thr853), increased activating phosphorylation of PRMT5 at Thr80, elevated symmetric dimethylation of histone H2A, and decreased retinoblastoma protein expression, defining a PPM1B/MP/PRMT5 oncogenic axis. Western blotting, PCR, immunohistochemistry in patient tissues, phospho-specific immunoblotting for MYPT1 and PRMT5 Biomolecules Medium 41301499

Source papers

Stage 0 corpus · 36 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nature cell biology 131 25751141
2008 PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Cellular signalling 93 18930133
2012 PPM1B negatively regulates antiviral response via dephosphorylating TBK1. Cellular signalling 62 22750291
2024 Modulation of YBX1-mediated PANoptosis inhibition by PPM1B and USP10 confers chemoresistance to oxaliplatin in gastric cancer. Cancer letters 47 38364962
2013 N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. The Biochemical journal 43 23088624
2016 DCAF4L2 promotes colorectal cancer invasion and metastasis via mediating degradation of NFκb negative regulator PPM1B. American journal of translational research 35 27158335
2013 The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity. The Biochemical journal 34 23320500
2015 miR-186 downregulates protein phosphatase PPM1B in bladder cancer and mediates G1-S phase transition. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 29 26494000
2011 The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability. The Journal of biological chemistry 29 21317290
2015 The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor. The Journal of biological chemistry 27 25631048
1998 The cloning expression and tissue distribution of human PP2Cbeta. FEBS letters 26 9684878
2022 Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis. Cell reports 23 36543144
2020 Berberine Improves Inflammatory Responses of Diabetes Mellitus in Zucker Diabetic Fatty Rats and Insulin-Resistant HepG2 Cells through the PPM1B Pathway. Journal of immunology research 23 32908938
2018 Potentially critical roles of TNPO1, RAP1B, ZDHHC17, and PPM1B in the progression of coronary atherosclerosis through microarray data analysis. Journal of cellular biochemistry 20 30269354
2021 Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation. The Journal of biological chemistry 19 33380426
2012 Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ. The Journal of biological chemistry 19 22393050
2021 Exosomal miR-181a-5p reduce Mycoplasma gallisepticum (HS strain) infection in chicken by targeting PPM1B and activating the TLR2-mediated MyD88/NF-κB signaling pathway. Molecular immunology 16 34715577
2023 A comprehensive overview of PPM1B: From biological functions to diseases. European journal of pharmacology 15 36863552
2023 Pleckstrin-2-promoted PPM1B degradation plays an important role in transforming growth factor-β-induced breast cancer cell invasion and metastasis. Cancer science 12 36928924
2014 PPM1B depletion induces premature senescence in human IMR-90 fibroblasts. Mechanisms of ageing and development 12 24674756
2013 PKA negatively regulates PP2Cβ to activate NF-κB-mediated inflammatory signaling. Biochemical and biophysical research communications 12 23756813
2020 Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B. Journal of cellular and molecular medicine 11 33048454
2018 PPM1B depletion in U2OS cells supresses cell growth through RB1-E2F1 pathway and stimulates bleomycin-induced cell death. Biochemical and biophysical research communications 10 29654756
2023 Circ_0006251 mediates the proliferation and apoptosis of vascular smooth muscle cells in CAD via enhancing TET3 and PPM1B expression. Cellular and molecular biology (Noisy-le-Grand, France) 6 37715433
2019 A heterozygous deficiency in protein phosphatase Ppm1b results in an altered ovulation number in mice. Molecular medicine reports 5 31059097
2025 PPM1B degradation mediated by TRIM25 ubiquitination modulates cell cycle and promotes gastric cancer growth. Scientific reports 3 39979355
2024 Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes. Frontiers in pharmacology 3 39439899
2021 [TRIM59 regulates invasion and migration of nasopharyngeal carcinoma cells by targeted modulation of PPM1B]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 3 34308852
2020 Clostridium difficile toxin B-induced colonic inflammation is mediated by the FOXO3/PPM1B pathway in fetal human colon epithelial cells. American journal of translational research 3 33194024
2025 BRISC-Mediated PPM1B-K63 Deubiquitination and Subsequent TGF-β Pathway Activation Promote High-Fat/High-Sucrose Diet-Induced Arterial Stiffness. Circulation research 2 39742393
2024 RBM10 regulates the tumorigenic potential of human cancer cells by modulating PPM1B and YBX1 activities. Experimental cell research 2 38246397
2023 TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment. Biochimica et biophysica acta. Molecular cell research 2 37506885
2023 Circ_0090231 knockdown protects vascular smooth muscle cells from ox-LDL-induced proliferation, migration and invasion via miR-942-5p/PPM1B axis during atherosclerosis. Molecular and cellular biochemistry 2 37515673
2023 Overexpression of PPM1B inhibited chemoresistance to temozolomide and proliferation in glioma cells. Cell biology international 2 37798941
2021 Ppm1b Negatively Regulates 3-Bromopyruvate Induced Necroptosis in Breast Cancer Cells. Frontiers in oncology 2 33520691
2025 Decreased PPM1B Expression Drives PRMT5-Mediated Histone Modification in Lung Cancer Progression. Biomolecules 0 41301499