Affinage

CCAR1

Cell division cycle and apoptosis regulator protein 1 · UniProt Q8IX12

Length
1150 aa
Mass
132.8 kDa
Annotated
2026-04-28
53 papers in source corpus 22 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CCAR1 is a nuclear scaffold protein that couples transcription factor activation to Mediator complex recruitment, regulates pre-mRNA splicing fidelity, and integrates apoptotic and cell-cycle signaling. As a transcriptional coactivator, CCAR1 bridges nuclear receptors (AR, GR, ER, CAR) and lineage-specific factors (GATA1, GATA2, Neurogenin3) to the Mediator complex (via MED1) and p160/SRC coactivators, enabling hormone- and differentiation-dependent gene expression, chromatin remodeling, and long-range enhancer–promoter communication (PMID:18722177, PMID:23887938, PMID:24811171, PMID:24245781). CCAR1 also functions as a splicing fidelity factor: its EF hand domain interacts with the U2AF spliceosome heterodimer to enforce poison-exon exclusion in FANCA and other transcripts, and loss of CCAR1 phenocopies Fanconi anemia pathway deficiency by impairing homology-directed repair and interstrand crosslink repair (PMID:38964321, PMID:39025073). CCAR1 additionally participates in apoptosis and NF-κB signaling through direct high-affinity binding to H2AX (Kd ~127 nM) and NEMO/IKKγ, selectively transducing DNA-damage and chemotherapy-induced signals, and interacts with APC-2 of the APC/C ubiquitin ligase to regulate G2/M progression (PMID:30769864, PMID:32024692, PMID:21903591).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2008 High

    Establishing CCAR1 as a transcriptional coactivator: it was unknown how nuclear receptors engage the Mediator complex, and CCAR1 was shown to bridge NRs and p160 coactivators to Mediator components and RNA Pol II at target promoters.

    Evidence Co-IP, ChIP, and siRNA knockdown across multiple NR target genes in mammalian cells

    PMID:18722177

    Open questions at the time
    • Which Mediator subunit(s) directly contact CCAR1
    • Whether CCAR1 is catalytically active or purely scaffolding
    • Structural basis of the NR–CCAR1–Mediator interface
  2. 2008 High

    Revealing a cytoplasmic role for CCAR1: beyond nuclear transcription, CCAR1 was shown to localize to RNA stress granules via AKAP350A in a microtubule-dependent manner, expanding its functional repertoire to RNA metabolism under stress.

    Evidence Co-IP, immunofluorescence, nocodazole disruption, and siRNA knockdown altering stress granule morphology

    PMID:19073175

    Open questions at the time
    • Whether CCAR1 directly binds RNA in stress granules
    • Functional consequence of altered stress granule morphology for mRNA fate
    • Relationship of stress granule role to transcriptional coactivator function
  3. 2010 High

    Connecting CCAR1 to DNA-damage-induced apoptosis: CCAR1 was found to interact with zyxin and to be required for UV-induced apoptosis, and separately its phosphorylation at T667 was shown to regulate binding to TAZ.

    Evidence Affinity pulldown, domain mapping, UV apoptosis assay in zyxin-null fibroblasts; Co-IP with TAZ and site-directed mutagenesis

    PMID:20594350 PMID:20852740

    Open questions at the time
    • Kinase responsible for T667 phosphorylation under physiological conditions
    • Whether zyxin and TAZ interactions are independent or coordinated
  4. 2011 High

    Linking CCAR1 to cell-cycle control: CCAR1 was shown to directly bind APC-2 of the APC/C ubiquitin ligase (Kd ~480 nM), and disruption of this interaction induced G2/M arrest and caspase-dependent apoptosis.

    Evidence Yeast two-hybrid, fluorescence polarization Kd measurement, small molecule (CFM-4) perturbation, siRNA knockdown

    PMID:21903591

    Open questions at the time
    • Whether CCAR1 is a substrate or regulator of APC/C activity
    • How APC-2 binding relates to CCAR1's transcriptional roles
  5. 2012 High

    Identifying post-translational control of CCAR1 itself: necdin was shown to promote CCAR1 ubiquitination and proteasomal degradation, thereby suppressing CCAR1-mediated apoptosis in myoblasts.

    Evidence Yeast two-hybrid, Co-IP, in vivo ubiquitination assay, proteasome inhibitor treatment, siRNA knockdown

    PMID:22905258

    Open questions at the time
    • Identity of the E3 ligase recruited by necdin
    • Whether necdin regulation operates in non-myoblast contexts
  6. 2013 High

    Broadening CCAR1's coactivator repertoire: CCAR1 was shown to co-activate AR via stabilization of AR–GATA2 interactions at enhancers and to co-activate GATA1 via a reconstituted GATA1–CCAR1–CoCoA–MED1 complex, demonstrating its role as a general NR/TF–Mediator bridge.

    Evidence Co-IP, ChIP, chromosome conformation capture (3C) at PSA locus; in vitro reconstitution of four-protein complex with reporter assays

    PMID:23887938 PMID:24245781

    Open questions at the time
    • Whether CCAR1 has pioneer-like chromatin opening activity
    • How CCAR1 distinguishes among different transcription factor partners
  7. 2013 High

    Revealing upstream transcriptional and splicing regulation of CCAR1 itself: the Par-4/THAP1 complex activates CCAR1 transcription, while Notch3 antagonizes this by shifting CCAR1 pre-mRNA splicing toward a shorter isoform via SRp40/SRp55.

    Evidence Co-IP, promoter reporter assay, alternative splicing analysis in T-ALL cells

    PMID:23975424

    Open questions at the time
    • Functional difference between long and short CCAR1 isoforms
    • Whether Notch3-mediated splicing regulation operates in non-leukemic cells
  8. 2014 High

    Establishing CCAR1 as a GR coactivator in adipogenesis: CCAR1 was recruited by GR to glucocorticoid response elements in the PPARγ gene and was required for chromatin remodeling and adipocyte differentiation.

    Evidence ChIP, siRNA knockdown in 3T3-L1 preadipocytes and mesenchymal stem cells with adipocyte differentiation readout

    PMID:24811171

    Open questions at the time
    • Whether CCAR1 is required for all GR target genes or a specific subset
    • Identity of chromatin remodelers recruited by CCAR1 at GR targets
  9. 2019 High

    Defining a direct, high-affinity CCAR1–H2AX interaction as a DNA-damage apoptosis signal transducer: the interaction (Kd 127 nM) was mapped to CCAR1 residues 636–650 and H2AX residues 1–35, and its disruption abolished γH2AX formation and apoptosis.

    Evidence Co-IP, SPR Kd measurement, deletion mutagenesis, co-localization imaging, apoptosis epistasis

    PMID:30769864

    Open questions at the time
    • Whether CCAR1 facilitates H2AX phosphorylation or acts downstream of it
    • Structural model of the CCAR1–H2AX interface
  10. 2020 High

    Delineating a selective NF-κB activation role: CCAR1 binds NEMO/IKKγ and is required specifically for chemotherapy (adriamycin)-induced but not cytokine-induced canonical NF-κB signaling.

    Evidence Co-IP, small molecule screen for NEMO–CCAR1 disruptors, siRNA knockdown with selective NF-κB phosphorylation readout

    PMID:32024692

    Open questions at the time
    • How CCAR1 distinguishes genotoxic from cytokine-triggered NEMO activation
    • Whether CCAR1–NEMO binding is constitutive or damage-induced
  11. 2021 High

    Revealing CCAR1 in a chromatin-modifying complex: KDM4B, CCAR1, and MED1 form a trimeric complex that demethylates H3K9 at osteoclast gene promoters upon RANKL stimulation, coupling CCAR1's Mediator-bridging role with histone demethylase activity.

    Evidence Co-IP, ChIP-seq, conditional KO mouse, small molecule KDM4B inhibition

    PMID:34031372

    Open questions at the time
    • Whether CCAR1 is required for KDM4B recruitment or vice versa
    • Generality of the KDM4B–CCAR1–MED1 complex beyond osteoclastogenesis
  12. 2022 High

    Identifying a stabilizing kinase for CCAR1: DCLK1 phosphorylates CCAR1 at Ser343, preventing its degradation and thereby sustaining β-catenin signaling and cancer stemness.

    Evidence Co-IP with domain mapping, phosphosite mutagenesis (S343A), siRNA knockdown, in vivo cancer stemness assays

    PMID:35522902

    Open questions at the time
    • Phosphatase that reverses Ser343 phosphorylation
    • Whether DCLK1-mediated stabilization feeds back on CCAR1's transcriptional or splicing functions
  13. 2024 High

    Discovering CCAR1 as a splicing fidelity factor: CCAR1's EF hand domain interacts with the U2AF spliceosome heterodimer to suppress poison-exon inclusion in FANCA pre-mRNA, and loss of CCAR1 phenocopies Fanconi anemia pathway deficiency by impairing HDR and interstrand crosslink repair.

    Evidence CRISPR inhibition screen, RNA-seq, RNA immunoprecipitation of FANCA pre-mRNA, Co-IP with U2AF, domain mutagenesis, HDR/ICL repair assays; independently replicated in two studies

    PMID:38964321 PMID:39025073

    Open questions at the time
    • Full repertoire of poison-exon-containing transcripts regulated by CCAR1
    • Whether CCAR1 EF hand binds calcium and how this relates to splicing
    • Whether splicing and transcriptional coactivator functions are mutually exclusive or concurrent

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown how CCAR1's distinct molecular activities — Mediator bridging, spliceosome interaction, APC/C binding, and H2AX/NEMO engagement — are coordinated or partitioned across different cellular contexts, and no structural model exists for any CCAR1 complex.
  • No crystal or cryo-EM structure of CCAR1 or any of its complexes
  • No systematic domain–function map integrating all known activities
  • Mechanism by which CCAR1 distinguishes transcriptional from splicing targets

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 7 GO:0060090 molecular adaptor activity 5 GO:0003723 RNA binding 2 GO:0042393 histone binding 1
Localization
GO:0005634 nucleus 5 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-74160 Gene expression (Transcription) 6 R-HSA-5357801 Programmed Cell Death 4 R-HSA-1266738 Developmental Biology 2 R-HSA-162582 Signal Transduction 2 R-HSA-73894 DNA Repair 2 R-HSA-8953854 Metabolism of RNA 2 R-HSA-1640170 Cell Cycle 1
Partners
ANAPC2GATA2H2AFXIKBKGKDM4BMED1U2AF1U2AF2
Complex memberships
GATA1-CCAR1-CoCoA-MED1 complexKDM4B-CCAR1-MED1 complexMediator coactivator complex (via MED1)

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 CCAR1 is required for Mediator complex recruitment by nuclear receptors (NRs) to target gene promoters. CCAR1 associates with components of the Mediator and p160 coactivator complexes, is recruited to endogenous NR target genes in response to hormone, and its depletion inhibits hormone-induced recruitment of Mediator components and RNA polymerase II to target gene promoters. Co-immunoprecipitation, ChIP, siRNA knockdown with endogenous gene expression readouts Molecular cell High 18722177
2008 CCAR1 localizes to RNA stress granules in a microtubule-dependent manner. CCAR1 was identified as a binding partner of the scaffolding protein AKAP350A; both proteins, along with caprin-1, relocate to G3BP-positive stress granules after arsenite treatment, and this relocalization requires intact microtubules. Reduction of CCAR1 expression altered the size and number of stress granules. Co-immunoprecipitation, immunofluorescence/live-cell imaging, nocodazole treatment, siRNA knockdown Experimental cell research High 19073175
2011 CCAR1 (CARP-1) directly binds the APC/C E3 ubiquitin ligase subunit APC-2, as well as APC/C co-activators Cdc20 and Cdh1. The CARP-1/APC-2 interaction has a dissociation constant of ~480 nM. Disruption of this interaction causes G2/M cell cycle arrest and apoptosis involving caspase-8 and -9 activation and loss of cyclin B1 and Cdc20. Yeast two-hybrid, fluorescence polarization assay, small molecule antagonist (CFM-4) functional studies, siRNA knockdown The Journal of biological chemistry High 21903591
2013 CCAR1 functions as an androgen receptor (AR) co-activator by stabilizing the interaction between AR and the pioneer factor GATA2. CCAR1 directly interacts with both AR and GATA2, promotes their co-occupancy on AR-binding enhancer sites, and is required for androgen-induced long-range enhancer-promoter interaction at the PSA locus. Co-immunoprecipitation, ChIP, chromosome conformation capture (3C), siRNA knockdown with gene expression and in vivo tumorigenicity readouts Nucleic acids research High 23887938
2013 Par-4 and THAP1 form a protein complex (via their carboxyl termini) that binds the CCAR1 promoter through THAP1's zinc-dependent DNA-binding domain and activates CCAR1 transcription, promoting apoptosis. Notch3 competitively binds the CCAR1 promoter and, via splicing factors SRp40 and SRp55, shifts CCAR1 pre-mRNA splicing toward a shorter isoform, antagonizing Par-4/THAP1 complex function. Co-immunoprecipitation, promoter reporter assay, alternative splicing analysis, siRNA/overexpression in T-ALL cells Oncogene High 23975424
2014 CCAR1 functions as a co-activator of the glucocorticoid receptor (GR) during adipogenesis. GR recruits CCAR1 to glucocorticoid response elements in the PPARγ gene, and CCAR1 is required for GR occupancy and chromatin remodeling at one PPARγ GBR. Depletion of CCAR1 markedly suppresses differentiation of mesenchymal stem cells and 3T3-L1 preadipocytes. ChIP, siRNA knockdown, adipocyte differentiation assays The Journal of biological chemistry High 24811171
2013 CCAR1 interacts with GATA1 and the Mediator coactivator MED1 (via the CCAR1/CoCoA pair). Recombinant GATA1, CCAR1, CoCoA, and MED1(1-602) form a complex in vitro, and CCAR1/CoCoA synergistically enhance GATA1-mediated transcription from the γ-globin promoter. In vitro reconstitution, co-immunoprecipitation, ChIP, reporter gene assay Genes to cells High 24245781
2012 Necdin promotes CCAR1 ubiquitination and proteasomal degradation to suppress CCAR1-mediated apoptosis in myoblasts. Necdin was identified as a CCAR1-interacting protein by two-hybrid screening; loss of necdin results in elevated CCAR1 and increased apoptosis. Yeast two-hybrid, co-immunoprecipitation, ubiquitination assay, proteasome inhibitor experiments, siRNA knockdown PloS one High 22905258
2010 CCAR1 (CARP-1) binds the LIM domain of the focal adhesion/nuclear protein zyxin. This interaction is required for UV-induced apoptosis: zyxin lacking the CCAR1-binding region shows reduced pro-apoptotic activity, and CCAR1 is a nuclear protein that accumulates in the nucleus upon UV-C exposure. Affinity pulldown, microsequence identification, deletion mapping, co-immunoprecipitation, UV-C apoptosis assay, zyxin-null fibroblast rescue Genes & cancer High 20852740
2010 CCAR1 threonine667 phosphorylation regulates its binding to the transcriptional co-activator TAZ. H89 (PKA inhibitor) treatment stimulates threonine phosphorylation of CCAR1, and a T667A substitution in CCAR1 disrupts binding to TAZ and abrogates H89-induced apoptosis. CCAR1 also suppresses c-myc transcription. Co-immunoprecipitation, site-directed mutagenesis, overexpression, Western blotting, apoptosis assay Journal of molecular signaling Medium 20594350
2012 CCAR1 directly interacts with and is required as a co-activator for Neurogenin3 (Ngn3)-mediated endocrine differentiation. CCAR1 association with Ngn3 was verified by pulldown and co-immunoprecipitation; depletion of CCAR1 inhibited Ngn3-initiated transdifferentiation of pancreatic ductal cells. Pulldown assay, co-immunoprecipitation, reporter gene assay, siRNA knockdown Biochemical and biophysical research communications Medium 22266316
2021 KDM4B physically associates with CCAR1 and MED1 in a trimeric complex. This KDM4B-CCAR1-MED1 complex occupies promoters of osteoclast-related genes upon RANKL stimulation, induces H3K9 demethylation (euchromatinization), and facilitates NF-κB p65 recruitment via direct interaction between KDM4B and p65, driving osteoclastogenesis. Co-immunoprecipitation, ChIP-sequencing, conditional KO mouse model, small molecule inhibition Bone research High 34031372
2019 CCAR1 directly binds H2AX (histone 2AX) and this interaction is required for apoptosis signaling after DNA damage. CCAR1 amino acids 636–650 contain the H2AX-interacting epitope, and H2AX residues 1–35 contain the CCAR1-binding epitope. Surface plasmon resonance measured a Kd of 127 nM. Cells expressing CCAR1(Δ600–652) are resistant to apoptosis and show diminished γH2AX. Co-immunoprecipitation, deletion mutagenesis, surface plasmon resonance, co-localization imaging, apoptosis assay Cancers High 30769864
2020 CCAR1 directly binds NEMO (IKKγ) and regulates the chemotherapy-activated canonical NF-κB pathway. Blockade of NEMO-CCAR1 binding diminishes adriamycin-induced p65/RelA phosphorylation but not TNFα- or IL-1β-induced NF-κB activation, indicating a selective role in chemotherapy-driven NF-κB signaling. Co-immunoprecipitation, high-throughput small molecule screening, siRNA knockdown, in vitro and in vivo NF-κB reporter/phosphorylation assays The Journal of biological chemistry High 32024692
2024 CCAR1 functions as a splicing fidelity factor required for proper mRNA processing of FANCA and many other transcripts. CCAR1 co-immunoprecipitates with FANCA pre-mRNA; its loss causes inclusion of a poison exon in FANCA mRNA, reducing FANCA protein and phenocopying Fanconi anemia pathway loss. The EF hand domain of CCAR1 is required for interaction with the U2AF heterodimer of the spliceosome and for poison exon excision. CRISPR inhibition screen, siRNA knockdown, RNA-seq transcriptomics, RNA immunoprecipitation, domain mutagenesis, co-immunoprecipitation with spliceosome components Molecular cell High 38964321 39025073
2024 CCAR1's EF hand domain mediates interaction with the U2AF heterodimer of the spliceosome, and this interaction is required for excision of a poison exon in FANCA pre-mRNA. Loss of CCAR1 abrogates FANCA protein expression and impairs both HDR and interstrand crosslink repair. Co-immunoprecipitation of CCAR1 with U2AF, RNA immunoprecipitation of FANCA pre-mRNA, domain mutagenesis, HDR/ICL repair assays Molecular cell High 38964321 39025073
2018 CCAR1 acts as an enhancer-dependent co-activator of the constitutive androstane receptor (CAR). CCAR1 was identified by co-immunoprecipitation using FLAG-tagged CAR; overexpression of CCAR1 selectively enhanced CAR-driven reporter activity from XREM and gtPBREM enhancers but not PBREM. CCAR1 is recruited to the gtPBREM of UGT1A1 by CAR and cooperates with p160 SRC coactivators. Co-immunoprecipitation with FLAG-CAR, reporter gene assay, siRNA knockdown, ChIP Molecular pharmacology Medium 30397001
2016 CCAR1 5' UTR contains structured elements that interact with miR-1254, leading to reciprocal stabilization of both the miRNA and CCAR1 mRNA—a 'miRancer' mechanism—rather than canonical miRNA-mediated repression. Luciferase reporter assays, RNA secondary structure analysis, miRNA/mRNA stability assays Cell research Medium 27002217
2013 PTH downregulates CCAR1 protein in osteoblasts via a PKA- and p38 MAPK-dependent (but ERK-independent) pathway, and causes nuclear-to-cytoplasmic translocation of CCAR1 protein. Western blotting, kinase inhibitors (H-89, GF109203X, U0126, SB203580), immunofluorescence in differentiated osteoblasts Biochemical and biophysical research communications Medium 23764399
2022 DCLK1 kinase interacts with CCAR1 through its C-terminal domain and phosphorylates CCAR1 at Ser343, which is essential for CCAR1 protein stabilization. DCLK1 positively regulates β-catenin signaling via CCAR1 to maintain cancer stemness. Co-immunoprecipitation, phosphorylation mapping, site-directed mutagenesis, siRNA knockdown, in vitro and in vivo cancer stemness assays Clinical and translational medicine High 35522902
2006 CCAR1 overexpression inhibits FAK (focal adhesion kinase) autophosphorylation at Y397 in breast cancer cells, identifying FAK as a downstream target of CCAR1's growth-regulatory function. Western blotting of FAK-397 phosphorylation in CCAR1 overexpressing cells American journal of surgery Low 17071197
2025 In mouse ESCs, Ccar1 prevents nuclear translocation of β-catenin to maintain ground-state pluripotency. siRNA-mediated Ccar1 knockdown promotes β-catenin nuclear translocation and upregulates Wnt target genes while reducing pluripotency markers. siRNA knockdown, immunofluorescence (β-catenin localization), qRT-PCR Biochemistry and biophysics reports Low 40978202

Source papers

Stage 0 corpus · 53 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2019 Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma. Theranostics 210 31281495
2008 CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Molecular cell 120 18722177
2008 Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules. Experimental cell research 65 19073175
2016 CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance. Cell research 64 27002217
2022 Immune responses to CCAR1 and other dermatomyositis autoantigens are associated with attenuated cancer emergence. The Journal of clinical investigation 51 35040440
2011 Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. The Journal of biological chemistry 41 21903591
2015 Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish. Current topics in microbiology and immunology 38 25033755
2015 CARP-1/CCAR1: a biphasic regulator of cancer cell growth and apoptosis. Oncotarget 38 25894788
2020 Circular RNA circRIMS1 Acts as a Sponge of miR-433-3p to Promote Bladder Cancer Progression by Regulating CCAR1 Expression. Molecular therapy. Nucleic acids 33 33230478
2006 Purification and molecular cloning of a DNA ADP-ribosylating protein, CARP-1, from the edible clam Meretrix lamarckii. Proceedings of the National Academy of Sciences of the United States of America 33 16945908
2014 Coregulator cell cycle and apoptosis regulator 1 (CCAR1) positively regulates adipocyte differentiation through the glucocorticoid signaling pathway. The Journal of biological chemistry 32 24811171
2013 Par-4/THAP1 complex and Notch3 competitively regulated pre-mRNA splicing of CCAR1 and affected inversely the survival of T-cell acute lymphoblastic leukemia cells. Oncogene 31 23975424
2010 The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis. Genes & cancer 29 20852740
2023 Association of Anti-CCAR1 Autoantibodies With Decreased Cancer Risk Relative to the General Population in Patients With Anti-Transcriptional Intermediary Factor 1γ-Positive Dermatomyositis. Arthritis & rheumatology (Hoboken, N.J.) 28 36762496
2022 Targeting DCLK1 overcomes 5-fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β-catenin pathway-mediated cancer stemness. Clinical and translational medicine 28 35522902
2021 The KDM4B-CCAR1-MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasis. Bone research 26 34031372
2017 Inhibition of CCAR1, a Coactivator of β-Catenin, Suppresses the Proliferation and Migration of Gastric Cancer Cells. International journal of molecular sciences 26 28230774
2023 m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1. Cancer gene therapy 25 37563361
2020 CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis. Cancer science 25 33403784
2013 CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2. Nucleic acids research 25 23887938
2014 DBC1/CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor. BioMed research international 23 25610865
2017 A CARP-1 functional mimetic loaded vitamin E-TPGS micellar nano-formulation for inhibition of renal cell carcinoma. Oncotarget 20 29285223
2015 Identification and Testing of Novel CARP-1 Functional Mimetic Compounds as Inhibitors of Non-Small Cell Lung and Triple Negative Breast Cancers. Journal of biomedical nanotechnology 20 26485930
2010 A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1. Journal of molecular signaling 20 20594350
2006 Pressure stimulates breast cancer cell adhesion independently of cell cycle and apoptosis regulatory protein (CARP)-1 regulation of focal adhesion kinase. American journal of surgery 20 17071197
2013 CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PloS one 18 23826121
2020 MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1. Toxicology and applied pharmacology 16 32422326
2014 CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells. PloS one 16 24598827
2012 Necdin enhances myoblasts survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1. PloS one 15 22905258
2018 A CARP-1 functional mimetic compound is synergistic with BRAF-targeting in non-small cell lung cancers. Oncotarget 12 30038713
2014 Mechanisms of neuroblastoma cell growth inhibition by CARP-1 functional mimetics. PloS one 12 25033461
2013 CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. Genes to cells : devoted to molecular & cellular mechanisms 12 24245781
2021 Telmisartan Facilitates the Anticancer Effects of CARP-1 Functional Mimetic and Sorafenib in Rociletinib Resistant Non-small Cell Lung Cancer. Anticancer research 11 34475041
2019 A H2AX⁻CARP-1 Interaction Regulates Apoptosis Signaling Following DNA Damage. Cancers 11 30769864
2016 CARP-1 functional mimetics are novel inhibitors of drug-resistant triple negative breast cancers. Oncotarget 11 27687593
2012 CCAR1 is required for Ngn3-mediated endocrine differentiation. Biochemical and biophysical research communications 11 22266316
2013 Cell cycle and apoptosis regulatory protein (CARP)-1 is expressed in osteoblasts and regulated by PTH. Biochemical and biophysical research communications 10 23764399
2020 Role of nano-lipid formulation of CARP-1 mimetic, CFM-4.17 to improve systemic exposure and response in osimertinib resistant non-small cell lung cancer. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 9 33220423
2018 CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans. Aging cell 9 30003683
2024 CCAR1 promotes DNA repair via alternative splicing. Molecular cell 8 38964321
2020 RP11‑284F21.9 promotes lung carcinoma proliferation and invasion via the regulation of miR‑627‑3p/CCAR1. Oncology reports 8 32945522
2022 Combined Transcriptomic and Proteomic Profiling to Unravel Osimertinib, CARP-1 Functional Mimetic (CFM 4.17) Formulation and Telmisartan Combo Treatment in NSCLC Tumor Xenografts. Pharmaceutics 7 35745729
2020 Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKγ protein enhances the anticancer effect of chemotherapy. The Journal of biological chemistry 5 32024692
2018 Cell Cycle and Apoptosis Regulator 1, CCAR1, Regulates Enhancer-Dependent Nuclear Receptor CAR Transactivation. Molecular pharmacology 4 30397001
2010 Cell cycle and apoptosis regulatory protein (CARP)-1 is a novel, adriamycin-inducible, diffuse large B-cell lymphoma (DLBL) growth suppressor. Cancer chemotherapy and pharmacology 4 20809119
2024 The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway. Molecular cell 3 39025073
2020 Novel aspects of Cell Division Cycle and Apoptosis Regulator 1 (CCAR1) protein in Morus notabilis: an in silico approach. Plant signaling & behavior 2 32693681
2023 CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. RNA biology 1 38126797
2025 Anti-Sp4 and anti-CCAR1 autoantibodies in UK vs US patients with adult and juvenile-onset anti-TIF1γ-positive myositis. Rheumatology (Oxford, England) 0 39514366
2025 circTUBD1-hnRNPK Regulates the Proliferation and Migration of LSCC by Targeting CCAR1. Cancer medicine 0 40130381
2025 circFTO binding with IGF2BP2 regulates trophoblast cells proliferation, migration, and invasion while mediating m6A modification of CCAR1 mRNA in spontaneous abortion. BMC molecular and cell biology 0 40604397
2025 Ccar1 prevents β-catenin nuclear translocation to sustain ground-state pluripotency in mouse ESCs under R2i. Biochemistry and biophysics reports 0 40978202
2024 Splicing regulation of DNA repair via CCAR1. Molecular cell 0 39059366