Affinage

WDR1

WD repeat-containing protein 1 · UniProt O75083

Length
606 aa
Mass
66.2 kDa
Annotated
2026-06-11
33 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

WDR1 (AIP1) is a WD-repeat protein that functions as an obligate co-factor of ADF/cofilin, binding F-actin to dramatically accelerate cofilin-mediated filament severing and depolymerization and thereby controlling actin turnover across diverse cell types (PMID:17515402, PMID:25915128). It localizes with cofilin to cortical actin and is required to deliver cofilin to the membrane skeleton; in its absence cofilin becomes aberrantly dispersed, F-actin accumulates in cytoplasmic aggregates, myosin is displaced from the cortex, and nuclear integrity is lost (PMID:29995657, PMID:31471458). WDR1 additionally suppresses residual severing activity of phosphorylated cofilin, integrating with the LIMK-cofilin and coronin-1A arms of actin regulation to set the balance of assembly versus disassembly (PMID:15629458, PMID:31471458, PMID:33928084). Its activity is tuned post-translationally by Src-mediated tyrosine phosphorylation, which is reversed by the EYA3 phosphatase, with loss of phosphorylation reshaping the cellular actin cytoskeleton (PMID:29440662). Through control of actomyosin remodeling and cortical tension, WDR1 governs cell-shape changes in epithelial planar cell polarity (PMID:25915128), talin-dependent integrin αIIbβ3 activation and clot retraction in platelets (PMID:27627652, PMID:29995657), cardiomyocyte organization during outflow-tract development (PMID:29654745), and dendritic spine morphology underlying hippocampal synaptic plasticity and learning (PMID:30590446). WDR1-dependent cytoskeletal tension also feeds into YAP/Hippo and RhoA-MRTF-A signaling to drive cancer cell proliferation and migration (PMID:28822708, PMID:35861209), and it can be sequestered by Keap1 and released to coordinate cofilin and Bax in mitochondrial apoptosis (PMID:34593792). Biallelic loss-of-function mutations in WDR1 cause human autoinflammatory disease, with elevated F-actin in neutrophils, impaired chemotaxis and a nuclear herniation phenotype, and excess IL-18/caspase-1 inflammasome activation (PMID:27557945, PMID:27994071).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2002 Low

    Established the first cellular context for WDR1, asking where it acts relative to actin regulators, and showing it co-distributes with ADF and F-actin at sites of high actin dynamics.

    Evidence In situ hybridization and immunocytochemistry co-localization in chick cochlea

    PMID:12115702

    Open questions at the time
    • Descriptive co-localization only, no functional intervention
    • Does not establish a direct biochemical interaction with cofilin/ADF
    • No quantitative effect on actin turnover measured
  2. 2005 Medium

    Addressed whether WDR1 merely assists cofilin or has a distinct regulatory role, showing in vitro that it abolishes residual severing by phosphorylated cofilin and is required for mitotic cell rounding.

    Evidence RNAi knockdown plus direct in vitro filament severing/disassembly assays and live-cell morphology

    PMID:15629458

    Open questions at the time
    • Single lab
    • Mechanism of how WDR1 suppresses phospho-cofilin activity not structurally resolved
    • Connection between mitotic rounding defect and severing activity inferential
  3. 2007 High

    Defined the in vivo requirement for the cofilin/WDR1 complex, using an allelic series to show that loss of WDR1 causes macrothrombocytopenia and autoinflammation through defective actin dynamics.

    Evidence Hypomorphic and null Wdr1 mouse alleles with megakaryocyte and neutrophil phenotyping

    PMID:17515402

    Open questions at the time
    • Did not resolve the molecular link between actin defects and inflammation
    • Cell-type-specific contributions not separated
  4. 2015 High

    Showed how WDR1-driven disassembly translates into tissue morphogenesis, demonstrating it is required for actomyosin remodeling and cortical tension that establish planar cell polarity.

    Evidence Conditional KO mice, live imaging, cortical tension measurement, epistasis with cofilin/destrin depletion

    PMID:25915128

    Open questions at the time
    • Upstream signals directing WDR1 activity in epidermis not defined
    • Link between cortical tension and PCP machinery not fully mechanistic
  5. 2016 High

    Established WDR1 as a human disease gene and confirmed its actin-depolymerizing role in primary cells, linking loss of function to neutrophil F-actin accumulation, impaired motility, and autoinflammation with elevated IL-18.

    Evidence Patient biallelic/missense mutation identification, proteomics, F-actin/G-actin measurement, chemotaxis assays, transplant rescue, caspase-1 cleavage and cytokine ELISA

    PMID:27557945 PMID:27994071

    Open questions at the time
    • Mechanism connecting actin dysregulation to inflammasome/IL-18 not fully defined
    • Pyrin aggregation data from transfection only
  6. 2016 Medium

    Dissected WDR1's role in platelet biology, showing it suppresses platelet activity via actin regulation and is required for talin-dependent integrin αIIbβ3 inside-out activation.

    Evidence MEG-01 KD/OE with functional readouts; Wdr1-hypomorphic mouse platelets, thrombosis models, JON/A flow cytometry, actin fractionation, talin imaging

    PMID:27609643 PMID:27627652

    Open questions at the time
    • Single lab for each study
    • Direct biochemical link between WDR1, talin redistribution, and integrin activation not reconstituted
    • STAT3-driven promoter regulation of WDR1 (27521604) shown only in cancer context
  7. 2018 High

    Identified post-translational control of WDR1, placing Src and the EYA3 phosphatase as writer and eraser of WDR1 tyrosine phosphorylation that reshapes the actin cytoskeleton.

    Evidence Phosphotyrosine peptide microarray, in vitro Src kinase and EYA3 phosphatase assays, WDR1 tyrosine mutagenesis, actin imaging

    PMID:29440662

    Open questions at the time
    • Functional consequence of specific phospho-sites in vivo not established
    • Whether phosphorylation alters cofilin binding directly untested
  8. 2018 Medium

    Refined WDR1's mechanistic role at the membrane skeleton and in development, showing it is required for cofilin localization and F-actin-focal adhesion interaction in platelets and for cardiomyocyte spatial organization in the heart.

    Evidence Wdr1-hypomorphic mouse platelets with co-localization and Co-IP; cardiac/SHF-specific conditional KO mice with histology and myofibrillar staining

    PMID:29654745 PMID:29995657

    Open questions at the time
    • Single lab studies
    • Cardiac phenotype mechanism limited to structural observation
    • Direct WDR1-FAK interaction not established
  9. 2019 High

    Resolved the consequences of unrestrained cofilin activity and established a tripartite regulatory network, showing coronin-1A depletion rescues WDR1-deficient neutrophils and that WDR1 enables actomyosin contractility and synaptic plasticity.

    Evidence Wdr1-deficient zebrafish with coronin 1A morpholino epistasis and myosin inhibitor; CA1-specific conditional KO mice with electrophysiology and behavior

    PMID:30590446 PMID:31471458

    Open questions at the time
    • Molecular basis of WDR1-coronin-1A functional interplay not biochemically defined
    • Whether eruptive cell death mechanism generalizes to mammalian neutrophils untested
  10. 2021 Medium

    Extended WDR1 into immune-synapse and apoptotic signaling, showing it cooperates with LIMK-cofilin in BCR-induced actin remodeling and is released from Keap1 to coordinate cofilin and Bax in mitochondrial apoptosis.

    Evidence B-cell siRNA KD with imaging and BCR signaling readouts; redox-targeting with Wdr1/cofilin depletions and in vivo DMF administration

    PMID:33928084 PMID:34593792

    Open questions at the time
    • Single lab for each
    • Direct WDR1-Bax and WDR1-Keap1 interactions not structurally resolved
    • Nrf2-independence of apoptotic mechanism incompletely mapped
  11. 2023 High

    Provided direct binding evidence and a defined complex, showing the small molecule gambogic amide binds WDR1 to promote a WDR1-MYH9-cofilin complex that accelerates depolymerization and induces apoptosis in glioma.

    Evidence CRISPR KO screen, CETSA, DARTS, SPR, docking, Co-IP, F-actin and apoptosis assays, PDX models

    PMID:37935665

    Open questions at the time
    • Endogenous (drug-independent) role of the WDR1-MYH9-cofilin complex not defined
    • Generality beyond glioma untested
  12. 2024 Medium

    Probed WDR1's role in cancer signaling pathways, linking its cytoskeletal activity to YAP/Hippo, RhoA-MRTF-A, and β-catenin axes that drive proliferation and migration.

    Evidence siRNA KD/OE in NSCLC, breast, and prostate cancer cells with fractionation, pathway inhibitors, reporter assays, and LiCl rescue

    PMID:28822708 PMID:35861209 PMID:38743149

    Open questions at the time
    • Prostate β-catenin link is pharmacological rescue only without direct biochemistry (Low confidence)
    • Whether signaling effects are universally downstream of actin tension not unified across tumor types

Open questions

Synthesis pass · forward-looking unresolved questions
  • How WDR1-dependent actin remodeling is mechanistically transduced into inflammasome/IL-18 activation and how its phospho-regulation and complex partners (MYH9, coronin-1A, Keap1) coordinate context-specific outputs remain unresolved.
  • No structural model of WDR1 on cofilin-decorated filaments
  • Causal chain from actin dysregulation to inflammasome assembly undefined
  • Endogenous regulatory inputs governing complex assembly unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 4 GO:0098772 molecular function regulator activity 2
Localization
GO:0005856 cytoskeleton 3 GO:0005829 cytosol 2
Pathway
R-HSA-168256 Immune System 5 R-HSA-109582 Hemostasis 2 R-HSA-1266738 Developmental Biology 2 R-HSA-162582 Signal Transduction 2 R-HSA-5357801 Programmed Cell Death 2
Partners
CFL1CORO1AEYA3KEAP1LIMKMYH9SRC
Complex memberships
WDR1-MYH9-cofilin complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 WDR1/Aip1 functions as a co-factor of cofilin to accelerate actin filament severing and depolymerization; loss-of-function (hypomorphic alleles) in mice causes macrothrombocytopenia due to megakaryocyte maturation defects and autoinflammatory disease with impaired cytoskeletal responses in neutrophils, establishing an essential in vivo role for the cofilin/WDR1 complex in actin dynamics in these cell types. Allelic series mouse genetics (hypomorphic and null Wdr1 alleles), cellular phenotyping of megakaryocytes and neutrophils, cytoskeletal assays Blood High 17515402
2016 Biallelic loss-of-function mutations in WDR1 in human patients cause elevated F-actin content (fourfold increase) in neutrophils, markedly impaired chemotaxis, cell polarization, and spreading, and a distinctive nuclear herniation phenotype, confirming that WDR1-dependent actin depolymerization is required for normal neutrophil morphology and motility. Identification of biallelic WDR1 mutations in patients, 2D-DIGE proteomics, F-actin/G-actin measurements, chemotaxis assays, allogeneic stem cell transplantation rescue Blood High 27557945
2016 A homozygous missense mutation in WDR1 causes autoinflammatory disease with elevated IL-18 (but not IL-1β) and increased caspase-1 cleavage in patient monocytes; mutant WDR1 protein forms aggregates that accumulate pyrin in transfected HEK293T cells, suggesting that impaired actin dynamics precipitates inflammasome assembly. Patient genetic analysis, ELISA for cytokines, caspase-1 cleavage assay in monocytes, transfection/aggregation assay in HEK293T cells The Journal of experimental medicine Medium 27994071
2005 Suppression of AIP1/WDR1 causes mitotic cell flattening instead of normal rounding; in vitro filament severing/disassembly assays showed that AIP1/WDR1 abolishes residual actin-severing activity of phosphorylated cofilin, indicating that WDR1 is required to fully suppress actin turnover and thereby enable mitotic cell rounding. RNAi knockdown in cells, direct in vitro actin filament severing/disassembly assay, live-cell morphology observation Biochemical and biophysical research communications Medium 15629458
2015 Wdr1 (Aip1), an F-actin-binding protein that enhances cofilin/destrin-mediated F-actin disassembly, is required for actomyosin remodeling, cortical tension generation, and the cell shape changes that establish planar cell polarity (PCP) in developing mouse epidermis; Wdr1 depletion alone recapitulates core PCP mutations. Conditional KO mice, live imaging, cortical tension measurements, genetic epistasis with cofilin/destrin double depletion Nature cell biology High 25915128
2016 WDR1 knockdown in megakaryoblastic MEG-01 cells increases F-actin content, adhesion, spreading, and basal intracellular calcium, and produces fewer but larger platelet-like particles with enhanced adhesion; WDR1 overexpression reverses these phenotypes, demonstrating that WDR1 suppresses platelet activity by regulating actin cytoskeleton dynamics. siRNA knockdown and overexpression in MEG-01 cells, F-actin measurement, adhesion/spreading assays, calcium imaging, platelet-like particle characterization Blood Medium 27609643
2016 In Wdr1-hypomorphic mouse platelets, actin turnover (F-actin/G-actin ratio) is impaired during collagen- and thrombin-induced aggregation, integrin αIIbβ3 inside-out activation is defective despite normal calcium responses, and talin fails to redistribute to the cytoskeleton, establishing that WDR1-mediated actin remodeling is required for talin-dependent αIIbβ3 activation. Wdr1-hypomorphic mice, bleeding time, FeCl3 thrombosis model, JON/A flow cytometry for activated αIIbβ3, F-actin/G-actin fractionation, talin immunofluorescence PloS one Medium 27627652
2018 Wdr-1 co-localizes with cofilin-1 in cortical actin of resting platelets and translocates together with cofilin-1 to the cytoskeleton upon fibrinogen adhesion; in Wdr-1-deficient platelets cofilin-1 is aberrantly distributed throughout the cytoplasm, F-actin fails to attach to focal adhesion kinase, and clot retraction and spreading are impaired, demonstrating that Wdr-1 is required for cofilin-1 localization to the membrane skeleton and F-actin–focal adhesion interaction. Wdr-1-hypomorphic mice, immunofluorescence/confocal co-localization, F-actin–focal adhesion kinase co-immunoprecipitation/immunoblotting, clot retraction assay, spreading assay Blood coagulation & fibrinolysis Medium 29995657
2018 EYA3 tyrosine phosphatase dephosphorylates WDR1 on tyrosine residues that are phosphorylated by Src kinase; loss of WDR1 tyrosine phosphorylation causes major changes to the cellular actin cytoskeleton, identifying WDR1 as an EYA3-specific substrate and placing Src/EYA3 as writer/eraser of WDR1 phosphorylation in cytoskeletal regulation. Phosphotyrosine peptide microarray to identify EYA3 substrates, in vitro kinase (Src) and phosphatase (EYA3/EYA1) assays, site-directed mutagenesis of WDR1 tyrosine residues, actin cytoskeleton imaging Scientific reports High 29440662
2019 In Wdr1-deficient zebrafish neutrophils, cofilin is predominantly unphosphorylated and associated with F-actin, displacing myosin; this leads to F-actin cytoplasmic aggregates, loss of phospho-myosin cortical localization, nuclear disorganization, and eruptive cell death. Depletion of coronin 1A fully rescues cortical F-actin distribution, nuclear integrity, viability, and mobility in Wdr1-deficient neutrophils, establishing a functional interplay between Wdr1, cofilin, and coronin 1A in regulating F-actin and actomyosin contractility. Wdr1-deficient zebrafish embryos, coronin 1A morpholino depletion, live imaging, F-actin/phospho-myosin immunofluorescence, myosin inhibitor experiments The Journal of cell biology High 31471458
2021 Wdr1 and LIMK have distinct roles in BCR-induced actin remodeling at the B cell immune synapse: Wdr1 enhances cofilin-mediated actin disassembly while LIMK phosphorylates and inactivates cofilin; both the Wdr1-LIMK-cofilin axis collectively controls peripheral actin assembly, B cell spreading, and actin-dependent amplification of BCR signaling. siRNA knockdown of Wdr1, LIMK, and Cotl1 in B cells, live imaging of BCR microcluster dynamics, spreading assays, BCR signaling measurements at immune synapse Frontiers in cell and developmental biology Medium 33928084
2021 In response to dimethyl fumarate (Tecfidera), Keap1-specific modification triggers dissociation of Wdr1 from Keap1; released Wdr1 then coordinates with cofilin to intercept Bax, driving mitochondrial-targeted apoptosis specifically in neutrophils and macrophages in a process largely independent of canonical Nrf2 signaling. Redox-targeting approach, genetic depletions of Wdr1 and cofilin, whole-animal DMF administration, mechanistic dissection via individual component knockdown Nature communications Medium 34593792
2018 Cardiac-specific or second-heart-field-specific deletion of Wdr1 in mice causes embryonic lethality with hypoplasia of the outflow tract and right ventricle, disrupted cardiomyocyte cellular organization and myofibrillar assembly without changes in cell number or proliferation, demonstrating that WDR1-mediated actin dynamics is required for spatial arrangement of cardiomyocytes during heart development. Conditional KO mice (Nkx2.5-Cre and SHF-Cre), histology, cell number/proliferation quantification, myofibrillar immunostaining Developmental biology Medium 29654745
2019 Conditional knockout of Wdr1 in hippocampal CA1 neurons in mice impairs actin depolymerization (via ADF/cofilin activity dysregulation), alters dendritic spine morphology, enhances LTP, impairs LTD, and causes deficits in reversal spatial learning and fear responses, establishing that Wdr1-mediated actin dynamics in hippocampal neurons is required for synaptic plasticity and associative learning. Conditional KO mice (CA1-specific), spine morphology analysis, electrophysiology (LTP/LTD), behavioral tests, actin dynamics (F-actin/G-actin fractionation), cofilin activity assay Cerebral cortex Medium 30590446
2023 The small molecule gambogic amide directly binds WDR1 (confirmed by CETSA, DARTS, molecular docking, and SPR), and through this interaction promotes formation of a WDR1–MYH9–cofilin complex that accelerates F-actin depolymerization, inhibits glioma cell invasion, and induces apoptosis via the mitochondrial pathway. CRISPR genome-wide KO screen, CETSA, DARTS, SPR, molecular docking, co-immunoprecipitation (WDR1–MYH9–cofilin complex), F-actin assay, apoptosis assay, PDX in vivo models Signal transduction and targeted therapy High 37935665
2017 WDR1 promotes nuclear import of MRTF-A by affecting expression of importin nuclear transport protein, thereby enhancing MRTF-A-induced breast cancer cell migration via RhoA-MRTF-A signaling; MRTF-A in turn drives expression of miR-206 which feeds back to suppress WDR1 and MRTF-A via their 3'UTRs. Overexpression and knockdown in MDA-MB-231 cells, nuclear/cytoplasmic fractionation, migration assays, qRT-PCR, 3'UTR luciferase reporter assays Experimental cell research Medium 28822708
2016 STAT3 binds directly to a putative promoter region (-1971 to -1964) of the WDR1 gene and its activation drives WDR1 overexpression in breast cancer cells; WDR1 overexpression increases MDA-MB-231 cell migration, which is attenuated by WDR1 knockdown. ChIP assay (STAT3 binding to WDR1 promoter), overexpression and knockdown, migration assays Cellular signalling Medium 27521604
2022 WDR1-mediated actin depolymerization reduces cortical stress, which promotes YAP nuclear trafficking and reduces YAP phosphorylation in NSCLC cells; knockdown of WDR1 decreases nuclear YAP and increases phosphorylated YAP via the Hippo pathway, linking WDR1-dependent cytoskeletal tension to YAP/Hippo signaling in proliferation and migration. siRNA knockdown, pharmacological disruption of cortical stress, nuclear/cytoplasmic YAP fractionation, YAP phosphorylation immunoblotting, Hippo pathway inhibitor experiments Experimental biology and medicine Medium 35861209
2024 WDR1 knockdown in prostate cancer cells inhibits proliferation, migration, and invasion; lithium chloride (Wnt/β-catenin pathway activator) restores these phenotypes, placing WDR1 upstream of β-catenin signaling as an activator of malignant behavior. siRNA knockdown and overexpression in PCa cell lines, proliferation/migration/invasion assays, LiCl rescue experiment Medical oncology Low 38743149
2002 WDR1 protein co-localizes with ADF and F-actin in hair cells, homogene cells, and cuboidal cells of the normal chick cochlea, and WDR1 mRNA is upregulated in supporting cells after acoustic overstimulation, indicating that WDR1 acts together with ADF at sites of high actin dynamics in the inner ear. In situ hybridization, immunocytochemistry, co-localization analysis in developing and noise-damaged chick cochlea The Journal of comparative neurology Low 12115702

Source papers

Stage 0 corpus · 33 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1. The Journal of experimental medicine 111 27994071
2007 Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood 95 17515402
2016 Cytoskeletal abnormalities and neutrophil dysfunction in WDR1 deficiency. Blood 91 27557945
2017 Functions of actin-interacting protein 1 (AIP1)/WD repeat protein 1 (WDR1) in actin filament dynamics and cytoskeletal regulation. Biochemical and biophysical research communications 60 29056508
2015 Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity. Nature cell biology 60 25915128
2016 Platelet WDR1 suppresses platelet activity and is associated with cardiovascular disease. Blood 55 27609643
2005 AIP1/WDR1 supports mitotic cell rounding. Biochemical and biophysical research communications 47 15629458
2023 The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling. Signal transduction and targeted therapy 46 37935665
2017 MRTF-A-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration. Experimental cell research 30 28822708
2018 WDR1 Promotes Cell Growth and Migration and Contributes to Malignant Phenotypes of Non-small Cell Lung Cancer through ADF/cofilin-mediated Actin Dynamics. International journal of biological sciences 26 29989053
2016 STAT3-induced WDR1 overexpression promotes breast cancer cell migration. Cellular signalling 26 27521604
2021 Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera. Nature communications 25 34593792
2018 WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton. Scientific reports 20 29440662
2019 MicroRNA-200a-3p Is a Positive Regulator in Cardiac Hypertrophy Through Directly Targeting WDR1 as Well as Modulating PTEN/PI3K/AKT/CREB/WDR1 Signaling. Journal of cardiovascular pharmacology 19 31651553
2002 WDR1 colocalizes with ADF and actin in the normal and noise-damaged chick cochlea. The Journal of comparative neurology 19 12115702
2021 The Wdr1-LIMK-Cofilin Axis Controls B Cell Antigen Receptor-Induced Actin Remodeling and Signaling at the Immune Synapse. Frontiers in cell and developmental biology 13 33928084
2020 TNK2-AS1 upregulated by YY1 boosts the course of osteosarcoma through targeting miR-4319/WDR1. Cancer science 13 33164271
2019 Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils. The Journal of cell biology 12 31471458
2016 Wdr1-Dependent Actin Reorganization in Platelet Activation. PloS one 9 27627652
2020 WD Repeat Domain 1 (WDR1) Deficiency Presenting as a Cause of Infantile Inflammatory Bowel Disease. Journal of pediatric gastroenterology and nutrition 8 32960541
2018 WDR1-regulated actin dynamics is required for outflow tract and right ventricle development. Developmental biology 8 29654745
2015 WDR1 and CLNK gene polymorphisms correlate with serum glucose and high-density lipoprotein levels in Tibetan gout patients. Rheumatology international 7 26438387
2022 YAP signaling is involved in WDR1-regulated proliferation and migration of non-small-cell lung cancer cells. Experimental biology and medicine (Maywood, N.J.) 6 35861209
2016 Genetic variation in WDR1 is associated with gout risk and gout-related metabolic indices in the Han Chinese population. Genetics and molecular research : GMR 5 27173277
2008 WDR1 presence in the songbird basilar papilla. Hearing research 5 18514449
2019 Hippocampal Wdr1 Deficit Impairs Learning and Memory by Perturbing F-actin Depolymerization in Mice. Cerebral cortex (New York, N.Y. : 1991) 4 30590446
2020 Long-noncoding RNA LINC00461 promotes proliferation and invasion of nonsmall cell lung cancer cells via targeting miR-518a-3p/WDR1 pathway. Journal of receptor and signal transduction research 3 33233986
2024 WDR1 promotes prostate cancer progression through Wnt/β-catenin signaling. Medical oncology (Northwood, London, England) 2 38743149
2007 WDR1 expression in the normal and noise-damaged chick vestibule. Journal of vestibular research : equilibrium & orientation 2 18525142
2018 Wdr-1 is essential for F-actin interaction with focal adhesions in platelets. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1 29995657
2013 WDR1 expression in normal and noise-damaged Sprague-Dawley rat cochleae. The Journal of comparative neurology 1 22821633
2024 LINC00668 silencing retards tumorigenesis via sponging miR-518c-3p to regulating WDR1 in triple negative breast cancer. International journal of biological macromolecules 0 39427801
2018 [Effect of germ cell Wdr1 deletion on the ovarian function of mice]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 0 30512154

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