Affinage

CTTN

Src substrate cortactin · UniProt Q14247

Length
550 aa
Mass
61.6 kDa
Annotated
2026-04-28
66 papers in source corpus 22 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Cortactin (CTTN/EMS1) is an F-actin-binding scaffold protein that couples extracellular signals to actin cytoskeletal remodeling, thereby controlling cell migration, invasion, endocytosis, endosomal homeostasis, and endothelial barrier integrity. It contains N-terminal tandem actin-binding repeats, a central helical-proline-rich region phosphorylated by ERK downstream of MEK on serine/threonine residues and by Src-family kinases on tyrosine, and a C-terminal SH3 domain; these domains are collectively required for its roles in lamellipodia dynamics, invadopodia formation, and clathrin-mediated endocytosis (PMID:9823470, PMID:10537323, PMID:8945620, PMID:21418910, PMID:35181549). CTTN protein levels are regulated by ubiquitin-proteasome-mediated degradation through the E3 ligases RNF128 and CBLC and by UCHL1-dependent K48-linked ubiquitination, and its transcription is activated by STAT3 and NF-κB and modulated by HIF and NRF2 pathways (PMID:30832692, PMID:36043996, PMID:32120844, PMID:19684620, PMID:39162263). Overexpression—frequently driven by 11q13 amplification—promotes cell migration, invasion, and anoikis resistance via PI3K/Akt signaling across multiple carcinoma types, while its depletion in endothelial cells increases vascular permeability in ARDS models and in circulating tumor cells triggers late-endosomal mTOR/p53-dependent senescence (PMID:17178864, PMID:35181549, PMID:8474448, PMID:9681820).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1993 Medium

    Establishing that EMS1 encodes cortactin and localizes to cell-substratum adherens-type junctions answered the fundamental question of where this amplified 11q13 gene product functions, linking it to cell-matrix adhesion rather than cell-cell junctions.

    Evidence Immunocytochemistry and sequence analysis in epithelial and carcinoma cell lines

    PMID:8474448

    Open questions at the time
    • No direct functional assay for junction regulation
    • Mechanism of recruitment to podosomes unknown
  2. 1998 Medium

    Domain mapping established cortactin as a modular scaffold with F-actin-binding repeats and an SH3 domain, while overexpression experiments demonstrated that cortactin is sufficient to drive cell migration and invasion independent of proliferation effects.

    Evidence Domain analysis plus stable overexpression in NIH3T3 with Boyden chamber assays

    PMID:9681820 PMID:9823470

    Open questions at the time
    • No loss-of-function data yet
    • Identity of SH3-domain binding partners not defined
    • Mechanism linking actin binding to migration not resolved
  3. 1999 High

    Identification of ERK-mediated serine/threonine phosphorylation in cortactin's helical-proline-rich region downstream of MEK, and correlation of tyrosine phosphorylation with Src-family kinase activity, defined the two principal phospho-regulatory axes controlling cortactin.

    Evidence In vitro kinase assays, MEK inhibitor (PD98059), constitutively active MEK, deletion mutagenesis, Src kinase activity correlation in breast cancer lines

    PMID:10537323 PMID:8945620

    Open questions at the time
    • Specific ERK phosphorylation sites not mapped to individual residues
    • Functional consequence of tyrosine phosphorylation not tested by mutagenesis
  4. 2006 High

    Loss-of-function experiments demonstrated that cortactin is required—not merely sufficient—for migration, invasion, and anoikis resistance in cancer cells, linking its function to PI3K/Akt pathway activation and in vivo metastasis.

    Evidence siRNA knockdown in ESCC cells with migration/invasion/anoikis assays, PI3K/Akt analysis, and xenograft lung metastasis model

    PMID:17178864

    Open questions at the time
    • Whether cortactin directly activates PI3K or acts indirectly is unresolved
    • Mechanism of anoikis protection beyond Akt not dissected
  5. 2009 High

    Demonstrating that STAT3 directly binds the CTTN promoter established the first defined transcriptional mechanism for cortactin upregulation, placing it downstream of a CRT–STAT3 signaling axis.

    Evidence ChIP for STAT3 on CTTN promoter, JAK inhibitor treatment, CTTN rescue experiments in ESCC cells

    PMID:19684620

    Open questions at the time
    • Other transcription factors contributing to basal CTTN expression not identified
    • Whether STAT3-CTTN axis operates in non-cancer contexts unknown
  6. 2011 Medium

    Domain-deletion mutagenesis coupled with transferrin uptake assays established that an intact cortactin molecule is required for clathrin-mediated endocytosis, expanding its role beyond migration to vesicular trafficking.

    Evidence siRNA knockdown and domain-deletion mutant expression with transferrin endocytosis assay in colon cancer cells

    PMID:21418910

    Open questions at the time
    • Specific domains essential for endocytosis versus migration not separately defined
    • No reconstitution in cell-free system
  7. 2019 Medium

    Discovery that RNF128 and UCHL1 regulate cortactin stability via K48-linked ubiquitination and proteasomal degradation revealed that cortactin protein levels are actively controlled by the ubiquitin-proteasome system, with downstream consequences for Wnt/β-catenin signaling and cell invasion.

    Evidence Ubiquitination assays (K48-linkage specificity), Co-IP, CTTN rescue experiments in melanoma and NPC cells

    PMID:30832692 PMID:32120844

    Open questions at the time
    • Direct E3 ligase–substrate structural interface not mapped
    • Relative contribution of RNF128 vs. UCHL1 in physiological contexts undefined
  8. 2022 High

    The Ser484Asn coding variant established a direct structure–function link between cortactin Tyr486 phosphorylation, nmMLCK binding, lamellipodia dynamics, and endothelial barrier recovery, validated in vivo by increased lung vascular permeability in Cttn+/- mice rescued only by WT CTTN.

    Evidence EC transgene expression, thrombin permeability assay, Co-IP for nmMLCK, Cttn+/- mouse ARDS model with liposomal gene delivery

    PMID:35181549

    Open questions at the time
    • Whether S484N variant affects cancer-related functions not tested
    • Structural basis for S484N disruption of Tyr486 phosphorylation unknown
  9. 2024 Medium

    Promoter-reporter and mutagenesis studies identified NF-κB, HIF, and NRF2 as transcriptional regulators of CTTN, and a promoter SNP (rs34612166) that enhances inflammatory induction, broadening understanding of how cortactin expression is regulated under stress.

    Evidence CTTN promoter-luciferase reporters, site-directed mutagenesis, chemical inhibitors, in vivo LPS mouse model

    PMID:39162263

    Open questions at the time
    • Combinatorial regulation by multiple transcription factors not dissected
    • Physiological significance of rs34612166 in human disease cohorts not validated
  10. 2025 Medium

    Cortactin was shown to localize to Rab7-positive late endosomes where it maintains endosomal homeostasis; its depletion triggers mTOR activation and p53-dependent oncogene-induced senescence in circulating tumor cells, revealing an unexpected tumor-suppressive consequence of cortactin loss in specific contexts.

    Evidence Live-cell imaging, CTC lines and CDX models, endosomal marker co-localization, mTOR/p53 pathway and senescence assays (preprint)

    PMID:bio_10.1101_2025.03.26.645381

    Open questions at the time
    • Preprint; not yet peer-reviewed
    • Whether endosomal tethering function is separable from actin-binding activity not tested
    • Generalizability beyond CTC lines unknown
  11. 2025 Medium

    Isoform-specific analyses demonstrated that splicing of CTTN—regulated by PTBP2 in response to matrix stiffness and by RBMS1 in cardiomyocytes—generates functionally distinct variants: WT-CTTN drives invasion while CTTN-Δe11 activates PI3K/AKT causing sarcomere damage and cardiac hypertrophy.

    Evidence Isoform overexpression/knockdown, matrix stiffness manipulation, invadopodia assays in NPC cells; splice factor knockdown plus PI3K inhibitor in cardiomyocytes

    PMID:38273817 PMID:41214391

    Open questions at the time
    • Structural differences between splice variants not resolved at atomic level
    • In vivo significance of stiffness-regulated splicing not confirmed

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include how cortactin coordinates its actin-binding, endosomal tethering, and signaling scaffold functions through distinct domain interactions, whether specific phosphorylation events control partitioning among these roles, and the structural basis for cortactin's interaction with its diverse E3 ligase regulators.
  • No high-resolution structural model of full-length cortactin or its complexes
  • Phosphosite-specific separation-of-function mutants for endosomal vs. migration roles not generated
  • Relative physiological importance of each E3 ligase in different tissues not determined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 3 GO:0060090 molecular adaptor activity 3
Localization
GO:0005856 cytoskeleton 3 GO:0005829 cytosol 2 GO:0005886 plasma membrane 2 GO:0005768 endosome 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-392499 Metabolism of proteins 3 R-HSA-74160 Gene expression (Transcription) 2 R-HSA-5653656 Vesicle-mediated transport 1
Partners
CBLCFAKMYLKRNF128UCHL1WASLYWHAG

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1993 The EMS1 gene encodes an 80/85-kDa protein (cortactin) that is homologous (85%) to a chicken v-src substrate. In epithelial cells, the protein localizes mainly in the cytoplasm, but in carcinoma cells overexpressing EMS1 due to gene amplification, it accumulates in podosome-like adherens junctions at cell-substratum contact sites (but not intercellular adherens junctions), suggesting a role in regulating interactions between components of adherens-type junctions. Amino acid sequence comparison, immunocytochemistry Molecular and cellular biology Medium 8474448
1998 Cortactin (EMS1) contains an F-actin binding tandem repeat domain, a proline-rich SH3-binding region, and a C-terminal SH3 domain, supporting its function in signal transmission between cell-matrix contact sites and the cytoskeleton. Both human p80 and p85 isoforms are encoded by the EMS1 cDNA. Gene transfer experiments, sequence analysis, Western blot, antiserum characterization Cell adhesion and communication Medium 9823470
1998 Overexpression of cortactin (EMS1) in NIH3T3 fibroblasts increases cell motility and invasion in modified Boyden chamber assays without affecting proliferation or anchorage dependence, establishing a direct role of cortactin overexpression in cell migration and invasion. Stable overexpression in NIH3T3 cells, Boyden chamber migration and invasion assays Oncogene Medium 9681820
1999 EGF treatment or cell detachment induces an 80–85 kDa mobility shift of EMS1 (cortactin) correlated with increased serine/threonine phosphorylation, and this shift is blocked by the MEK inhibitor PD98059 and mimicked by constitutively active MEK. ERKs are candidate kinases for this phosphorylation, occurring in the helical-proline-rich region, which is required for the phosphorylation event. In vitro kinase assays, MEK inhibitor treatment (PD98059), constitutively active MEK expression, deletion mutagenesis, metabolic phospholabeling Cancer research High 10537323
1996 EMS1 (cortactin) is tyrosine phosphorylated in breast cancer cell lines, and the degree of tyrosine phosphorylation correlates with src-family kinase activity, identifying src-family kinases as candidate tyrosine kinases for cortactin phosphorylation. Western blotting, tyrosine phosphorylation analysis, src-family kinase activity assays International journal of cancer Medium 8945620
2006 siRNA-mediated silencing of CTTN in ESCC cells reduces cell migration, invasiveness, and anoikis resistance, and the protective role of CTTN in anoikis resistance is correlated with activation of the PI3K/Akt pathway. In vivo, inhibition of CTTN decreases tumor growth and lung metastasis. siRNA knockdown, cell migration assay, anoikis resistance assay, PI3K/Akt pathway analysis, in vivo xenograft Cancer research High 17178864
2008 Cortactin (CTTN) and N-WASP (WASL), two regulators of actin network assembly known to be components of podosomes, are concentrated at tubulobulbar complexes in the rat testis seminiferous epithelium, which are podosome-like structures proposed to internalize junctions during sperm release. Immunofluorescence microscopy, immunoelectron microscopy of fixed rat testis Biology of reproduction Medium 18799755
2009 STAT3 directly binds to the CTTN promoter as shown by chromatin immunoprecipitation assay, upregulating CTTN mRNA expression. Calreticulin (CRT) regulates anoikis resistance and cell motility through a CRT-STAT3-CTTN-PI3K-Akt signaling axis in ESCC cells. siRNA knockdown, ChIP assay, JAK inhibitor treatment, CTTN rescue experiments, cell migration/invasion assays Oncogene High 19684620
2019 RNF128, an E3 ubiquitin ligase, ubiquitinates and degrades CTTN (cortactin); its downregulation leads to CTTN accumulation and activation of Wnt/β-catenin signaling, promoting EMT and stemness in melanoma cells. siRNA knockdown, ubiquitination assays, Wnt pathway analysis, functional cell assays Journal of hematology & oncology Medium 30832692
2020 UCHL1 (a deubiquitinase) interacts with CTTN and promotes its degradation via K48-linked ubiquitination, and restoration of CTTN rescues UCHL1-mediated suppression of NPC cell migration and invasion, identifying UCHL1 as a writer/eraser for CTTN ubiquitination. Co-IP, ubiquitination assay (K48-linked), CTTN rescue experiments, migration/invasion assays Cells Medium 32120844
2022 The CTTN coding SNP Ser484Asn (rs56162978) delays endothelial cell (EC) barrier recovery following thrombin-induced permeability, reduces Tyr486 cortactin phosphorylation, inhibits binding to nmMLCK (a cytoskeletal regulator), and attenuates lamellipodia dynamics. Cttn+/- mice show increased lung vascular permeability after ARDS challenge, reversed by WT CTTN but not S484N CTTN transgene delivery. EC transgene expression, thrombin permeability assay, phosphorylation analysis, Co-IP (nmMLCK binding), biophysical measurements, mouse lung vascular permeability model, liposomal gene delivery Translational research High 35181549
2022 CBLC (an E3 ubiquitin ligase) interacts with CTTN in the cytoplasm and promotes CTTN degradation through the ubiquitin-proteasome pathway, inhibiting breast cancer cell proliferation, migration, and invasion. The inhibitory effect of CBLC is partially reversed by CTTN overexpression. Co-IP, immunofluorescence co-localization, proteasome inhibitor assay, CTTN rescue experiments Journal of receptor and signal transduction research Medium 36043996
2024 YWHAG (14-3-3γ) interacts with CTTN and mediates its tumor-promoting functions by activating Wnt/β-catenin signaling in colorectal cancer cells, promoting proliferation, migration, and invasion. Co-IP, RNA-seq, Wnt pathway analysis, functional cell assays Medical oncology Low 38538804
2024 CTTN is required for matrix stiffness-induced cell migration, invasion, and invadopodia formation in NPC cells. The splicing factor PTBP2, activated by high stiffness, promotes expression of the WT-CTTN isoform over splice variants (SV1, SV2), and WT-CTTN is the functional form driving these malignant behaviors. siRNA knockdown, overexpression of WT/splice variant CTTN, matrix stiffness manipulation, invasion/migration assays, invadopodia formation assays Cancer science Medium 38273817
2025 RBMS1 promotes splicing of CTTN to generate a CTTN-Δe11 isoform, which activates the PI3K/AKT signaling pathway, leading to cytoskeleton and sarcomere damage in cardiomyocytes and contributing to cardiac hypertrophy. RNA-binding protein overexpression/knockdown, splicing isoform analysis, PI3K/AKT pathway measurement, cardiomyocyte functional assays, pharmacological inhibition EMBO molecular medicine Medium 41214391
2025 In HNSCC cells, CTTN knockdown reduces FAK expression and impairs cytoskeletal formation, diminishing anti-apoptotic (anoikis-resistance) capacity. CTTN silencing significantly suppressed growth in patient-derived organoids (PDOs). CTTN knockdown, PI staining, immunofluorescence, Western blot, patient-derived organoid assays Scientific reports Medium 41168318
2025 Cortactin localizes to Rab7-positive late endosomes and participates in late endosomal tethering and homeostasis. Depletion of cortactin causes accumulation of enlarged Rab7/mTOR-positive late endosomal aggregates, leading to mTOR activation and p53 phosphorylation (S15 and S33), driving G0/G1 arrest and cellular senescence (OIS) in circulating tumor cells. A positive feedback loop between p53 and mitochondrial ROS maintains stable senescence. Live-cell imaging, patient-derived CTC lines, CDX animal models, cortactin depletion, endosomal marker co-localization, mTOR/p53 pathway analysis, senescence assays (β-gal, Ki-67, Lamin B1, SASP, mtROS) bioRxivpreprint Medium bio_10.1101_2025.03.26.645381
2011 Cortactin expression is required for optimal endocytosis in colon cancer cells; siRNA silencing of CTTN reduces transferrin uptake, and domain deletion mutants of cortactin fail to support endocytosis, indicating an intact cortactin molecule is necessary for clathrin-coated vesicle transport. siRNA knockdown, DNA transfection with domain deletion mutants, transferrin endocytosis assay, immunohistochemistry, Western blot Zhonghua yi xue za zhi Medium 21418910
2025 LAD1 specifically binds to LINC01305 and co-regulates the phosphorylation levels of CTTN and N-WASP, mediating cytoskeletal reorganization and promoting ESCC cell metastasis, with LINC01305/LAD1 activating PI3K/AKT signaling. Co-IP, phosphorylation analysis, cell migration/invasion assays, PI3K/AKT pathway analysis Molecular carcinogenesis Low 39835575
2019 HBx (Hepatitis B virus X protein) interacts with CTTN (cortactin), as validated by co-immunoprecipitation and confocal microscopy, and regulates CTTN expression. The HBx-CTTN interaction enhances cell proliferation and migration by upregulating CREB1 and its downstream targets cyclin D1 and MMP-9. Co-immunoprecipitation, confocal microscopy, cell proliferation/migration assays, CREB1/downstream target analysis Cell death & disease Medium 31138777
2024 LPS, TNF-α, and pathological cyclic stretch (18%CS) increase CTTN promoter activity in a time-dependent manner, mediated at least partly through NF-κB response elements. HIF pathway activation and NRF2 modulation also regulate CTTN promoter activity. A promoter SNP (rs34612166, -212T/C) markedly enhances LPS- and CS-induced CTTN promoter activation. CTTN promoter-luciferase reporter assays, site-directed mutagenesis of promoter SNPs, chemical inhibitors of HIF/NRF2/NF-κB, in vivo LPS mouse model with IHC Bioscience reports Medium 39162263
2025 Nuclear miR-124-3p promotes Cttn transcription (not post-transcriptional silencing) by targeting the Cttn promoter via an importin/Ago1/2-dependent mechanism, and Cttn is required for neurite outgrowth and growth cone formation after spinal cord injury. RNA immunoprecipitation, RNA pull-down, ChIP assay, siRNA knockdown, cDNA overexpression, neurite outgrowth assays in PC12 cells, in vivo rat SCI model Molecular neurobiology Medium 40044957

Source papers

Stage 0 corpus · 66 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1992 Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene 362 1532244
1995 The involvement of the chromosome 11q13 region in human malignancies: cyclin D1 and EMS1 are two new candidate oncogenes--a review. Gene 242 7607576
2003 Cyclin D1, EMS1 and 11q13 amplification in breast cancer. Breast cancer research and treatment 201 12755491
1993 The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites. Molecular and cellular biology 152 8474448
2003 FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. International journal of oncology 146 12739008
2019 Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma. Journal of hematology & oncology 142 30832692
2008 Signaling of cell fate determination by the TPD1 small protein and EMS1 receptor kinase. Proceedings of the National Academy of Sciences of the United States of America 140 18250314
2006 Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance. Cancer research 132 17178864
1998 Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro. Oncogene 126 9681820
1996 Expression of cyclin D1 and EMS1 in bladder tumours; relationship with chromosome 11q13 amplification. Oncogene 125 8622895
1999 Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin. Cancer research 110 10537323
2019 BES1 is activated by EMS1-TPD1-SERK1/2-mediated signaling to control tapetum development in Arabidopsis thaliana. Nature communications 109 31519953
1997 EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer. Oncogene 84 9380415
2009 Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma. Oncogene 70 19684620
2016 Two SERK Receptor-Like Kinases Interact with EMS1 to Control Anther Cell Fate Determination. Plant physiology 68 27920157
2008 Cortactin (CTTN), N-WASP (WASL), and clathrin (CLTC) are present at podosome-like tubulobulbar complexes in the rat testis. Biology of reproduction 68 18799755
2016 Control of Anther Cell Differentiation by the Small Protein Ligand TPD1 and Its Receptor EMS1 in Arabidopsis. PLoS genetics 62 27537183
2007 Heterologous production of Pseudomonas aeruginosa EMS1 biosurfactant in Pseudomonas putida. Bioresource technology 61 17611103
2006 Recurrent coamplification of cytoskeleton-associated genes EMS1 and SHANK2 with CCND1 in oral squamous cell carcinoma. Genes, chromosomes & cancer 56 16235239
1996 Amplification and expression of EMS-1 (cortactin) in head and neck squamous cell carcinoma cell lines. Oncogene 54 8552396
2019 EMS1 and BRI1 control separate biological processes via extracellular domain diversity and intracellular domain conservation. Nature communications 49 31519884
2017 Carbonic Anhydrases Function in Anther Cell Differentiation Downstream of the Receptor-Like Kinase EMS1. The Plant cell 44 28522549
1993 Amplified region of chromosome band 11q13 in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMS1. Genes, chromosomes & cancer 44 7685625
2006 Amplifications of TAOS1 and EMS1 genes in oral carcinogenesis: association with clinicopathological features. Oral oncology 39 17005439
2019 The HBx-CTTN interaction promotes cell proliferation and migration of hepatocellular carcinoma via CREB1. Cell death & disease 36 31138777
1996 Expression and tyrosine phosphorylation of EMS1 in human breast cancer cell lines. International journal of cancer 34 8945620
1998 Characterization of the EMS1 gene and its product, human Cortactin. Cell adhesion and communication 33 9823470
2009 Detection of copy number amplification of cyclin D1 (CCND1) and cortactin (CTTN) in oral carcinoma and oral brushed samples from areca chewers. Oral oncology 27 19666237
2014 MTSS1 suppresses cell migration and invasion by targeting CTTN in glioblastoma. Journal of neuro-oncology 26 25385572
2020 Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN). Cells 24 32120844
2020 Long Noncoding RNA (lncRNA) CTTN-IT1 Elevates Skeletal Muscle Satellite Cell Proliferation and Differentiation by Acting as ceRNA for YAP1 Through Absorbing miR-29a in Hu Sheep. Frontiers in genetics 24 32849826
2023 LncRNA INPP5F ameliorates stress-induced hypertension via the miR-335/Cttn axis in rostral ventrolateral medulla. CNS neuroscience & therapeutics 19 36852438
2011 Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival. Cancer biomarkers : section A of Disease markers 19 22297550
2020 piR-19166 inhibits migration and metastasis through CTTN/MMPs pathway in prostate carcinoma. Aging 18 32881713
2021 EMS1/DLL4-Notch Signaling Axis Augments Cell Cycle-Mediated Tumorigenesis and Progress in Human Adrenocortical Carcinoma. Frontiers in oncology 17 34858850
2020 Long Noncoding RNASBF2-AS1 Promotes Gastric Cancer Progression via Regulating miR-545/EMS1 Axis. BioMed research international 14 32626753
2018 MiRNA-545 negatively regulates the oncogenic activity of EMS1 in gastric cancer. Cancer medicine 14 29733519
2018 MiR-448 downregulates CTTN to inhibit cell proliferation and promote apoptosis in glioma. European review for medical and pharmacological sciences 14 29949161
2011 An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers. Human molecular genetics 14 22171072
2016 Amplification and overexpression of CTTN and CCND1 at chromosome 11q13 in Esophagus squamous cell carcinoma (ESCC) of North Eastern Chinese Population. International journal of medical sciences 13 27877079
2023 CTTN Overexpression Confers Cancer Stem Cell-like Properties and Trastuzumab Resistance via DKK-1/WNT Signaling in HER2 Positive Breast Cancer. Cancers 9 36831511
2024 Stiffness promotes cell migration, invasion, and invadopodia in nasopharyngeal carcinoma by regulating the WT-CTTN level. Cancer science 8 38273817
2023 The receptor-like kinase EMS1 and BRI1 coordinately regulate stamen elongation via the transcription factors BES1/BZR1 in Arabidopsis. Plant science : an international journal of experimental plant biology 8 36931564
2022 Engineering Chimeras by Fusing Plant Receptor-like Kinase EMS1 and BRI1 Reveals the Two Receptors' Structural Specificity and Molecular Mechanisms. International journal of molecular sciences 8 35216268
2022 A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects. Translational research : the journal of laboratory and clinical medicine 7 35181549
2024 YWHAG promotes colorectal cancer progression by regulating the CTTN-Wnt/β-catenin signaling axis. Medical oncology (Northwood, London, England) 6 38538804
2022 CBLC inhibits the proliferation and metastasis of breast cancer cells via ubiquitination and degradation of CTTN. Journal of receptor and signal transduction research 5 36043996
2007 G6PD (AC)n and (CTT)n microsatellites in Mexican Mestizos with common G6PD African variants. Blood cells, molecules & diseases 5 17223593
2013 Synergistic effect of EMS1-shRNA and sorafenib on proliferation, migration, invasion and endocytosis of SMMC-7721. Journal of molecular histology 4 24127012
2012 Association of CTTN polymorphisms with the risk of colorectal cancer. Journal of the Korean Surgical Society 4 22403749
2025 Nuclear MicroRNA-124-3p Promotes Neurite Outgrowth After Spinal Cord Injury by Enhancing Cttn Transcription. Molecular neurobiology 3 40044957
2024 Genetic and epigenetic regulation of cortactin (CTTN) by inflammatory factors and mechanical stress in human lung endothelial cells. Bioscience reports 3 39162263
2013 Combining cortactin and CTTN detection with clinicopathologic features increases effectiveness of survival predictions for patients with resectable hepatocellular carcinoma. Clinical laboratory 2 24409670
2011 [Interference of invasion and metastasis of colorectal cancer cells by EMS1-siRNA encoded by a recombinant lentiviral vector]. Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 2 22116727
1997 [HS1 and EMS1]. Gan to kagaku ryoho. Cancer & chemotherapy 2 9309140
2025 LINC01305 and LAD1 Co-Regulate CTTN and N-WASP Phosphorylation, Mediating Cytoskeletal Reorganization to Promote ESCC Metastasis. Molecular carcinogenesis 1 39835575
2025 CTTN overexpression in HNSCC inhibits Anoikis-apoptosis. Scientific reports 1 41168318
2025 RBMS1 orchestrates cardiac hypertrophy by facilitating CTTN splice-switching and sarcomere dynamics. EMBO molecular medicine 1 41214391
2024 Combined RNAi of CTTN and FGF2 Modulates Cell Migration, Invasion and G1/S Transition of Hepatocellular Carcinoma through Ras/ERK Signaling Pathway. Current cancer drug targets 1 38031266
2008 [Expression and clinical significance of EMS1 gene in gastric carcinoma]. Ai zheng = Aizheng = Chinese journal of cancer 1 18334127
2026 Transcriptional factor ZMYM3 promotes hepatocellular carcinoma metastasis by upregulating CTTN and inducing invadopodia formation. Cell death & disease 0 41775697
2025 RETRACTION: MiRNA-545 Negatively Regulates the Oncogenic Activity of EMS1 in Gastric Cancer. Cancer medicine 0 40583825
2011 [A pivotal role of cortactin, a CTTN encoding protein, in endocytosis of human colon cancer]. Zhonghua yi xue za zhi 0 21418910
2010 [The expression of EMS1 and DcR3 protein in laryngeal carcinoma and the relation between EMS1 and DcR3]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery 0 21395182
2009 [Expression of EMS1 protein and its clinical significance in laryngeal carcinoma]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery 0 19947248
2005 [Amplification of EMS1 gene in oral carcinogenesis]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 0 15842855