Affinage

TACC3

Transforming acidic coiled-coil-containing protein 3 · UniProt Q9Y6A5

Length
838 aa
Mass
90.4 kDa
Annotated
2026-06-10
100 papers in source corpus 45 papers cited in narrative 45 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 10/10 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TACC3 is a centrosome- and spindle-associated coiled-coil protein that organizes mitotic microtubule architecture downstream of Aurora A kinase, and additionally moonlights as a nuclear transcriptional regulator and translational repressor (PMID:16172205, PMID:17545617, PMID:36864125). Its central activity in mitosis is governed by Aurora A: TACC3 docks onto a pocket on Aurora A via a hydrophobic motif centered on F525, potently activating the kinase, which in turn phosphorylates human TACC3 at Ser558 (PMID:26134678, PMID:29510984). This phosphorylation drives a disordered-to-helical conformational switch that creates a binding surface for the ankle region of clathrin heavy chain, recruiting TACC3 to the mitotic spindle (PMID:29510984, PMID:20566684). There, TACC3, ch-TOG, and clathrin assemble into a complex that crosslinks microtubules within kinetochore fibers via inter-microtubule bridges, maintaining K-fiber tension and enabling spindle checkpoint satisfaction (PMID:21297582, PMID:23532825, PMID:33380489). The TACC domain of TACC3 binds ch-TOG and possesses intrinsic microtubule-nucleating activity, and TACC3 facilitates γ-TuRC assembly at spindle poles to control astral microtubule nucleation in a Ser558-phosphorylation-dependent manner (PMID:24273164, PMID:25246530, PMID:31823729). A distinct Aurora A/clathrin-independent TACC3–ch-TOG pool tracks microtubule plus ends together with XMAP215 to promote microtubule polymerization and axon outgrowth (PMID:25187649, PMID:25596274). Originally characterized as the Xenopus protein Maskin, TACC3 represses translation of CPE-containing mRNAs such as cyclin B1 by binding eIF4E and blocking eIF4G, an interaction released by CDK1 phosphorylation during the cell cycle (PMID:11081630, PMID:12110596, PMID:17086181). In the nucleus, TACC3 partners with FOG-1, an MBD2/pCAF acetyltransferase complex, the NuRD complex, and Notch intracellular domains to regulate transcription and differentiation (PMID:15037632, PMID:16410616, PMID:20804727, PMID:36864125). TACC3 protein levels are controlled by APC/C(CDH1)-mediated ubiquitin-proteasome degradation during mitotic exit (PMID:19823035, PMID:25375378). In cancer, the recurrent FGFR3-TACC3 fusion drives transformation through FGFR3 kinase activity and a TACC3-dominant sequestration of endogenous spindle TACC3, and TACC3 supports proliferation in centrosome-amplified tumors via KIFC1-dependent centrosome clustering and NuRD-mediated tumor-suppressor silencing (PMID:28855393, PMID:30344944, PMID:36864125).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2000 High

    Established that the TACC3 ortholog Maskin couples mRNA translational control to the mitotic apparatus by repressing cyclin B1 translation, revealing a non-microtubule function.

    Evidence Co-IP, antibody/mRNA injection and in situ localization in Xenopus embryos

    PMID:11081630

    Open questions at the time
    • Whether mammalian TACC3 retains this eIF4E-binding translational role was not addressed
    • Link between translational repression and spindle function unresolved
  2. 2002 High

    Defined how the Maskin-eIF4E repressive complex is dissolved, showing PABP binding to eIF4G displaces Maskin upon cytoplasmic polyadenylation.

    Evidence Antibody/mRNA injection and biochemical binding assays in Xenopus oocytes

    PMID:12110596

    Open questions at the time
    • Cell-cycle timing of dissociation not yet integrated with kinase signaling
  3. 2005 High

    Identified Aurora A as the kinase phosphorylating TACC3/Maskin on a conserved serine and demonstrated this controls centrosomal targeting and XMAP215-dependent microtubule assembly, linking TACC3 to spindle organization.

    Evidence In vitro kinase assays, reciprocal Co-IP, immunodepletion/add-back and purified-protein reconstitution in Xenopus egg extracts

    PMID:15687499 PMID:15788567 PMID:16172205 PMID:16172207

    Open questions at the time
    • Exact human phosphosite not yet mapped
    • How phosphorylation alters protein structure unknown
  4. 2006 High

    Resolved how CDK1 phosphorylation cycling, opposed by calcineurin/PKA, oscillates TACC3-eIF4E binding with the cell cycle, separating translational from localization functions.

    Evidence Phosphosite mapping by MS, site-directed mutagenesis, in vitro kinase/phosphatase and cell-free translation assays in Xenopus

    PMID:16107707 PMID:17086181

    Open questions at the time
    • Conservation of CDK1-regulated eIF4E control in mammalian cells not established
  5. 2006 Medium

    Showed NDEL1 mediates Aurora A-dependent centrosome targeting of TACC3, placing TACC3 recruitment downstream of an Aurora A-NDEL1 axis.

    Evidence Co-IP, siRNA knockdown and phospho-mutant rescue in mouse cells

    PMID:17060449

    Open questions at the time
    • Single lab
    • Direct vs indirect NDEL1-TACC3 contact not structurally defined
  6. 2007 High

    Mapped the human Aurora A phosphosite to Ser558 and established it as essential for TACC3 spindle/centrosome localization in human cells, providing a pharmacologically tractable handle.

    Evidence In vitro kinase assay, mutagenesis, Aurora A inhibitor (MLN8054) and xenograft pharmacodynamics

    PMID:17545617

    Open questions at the time
    • Downstream effector of pSer558 not yet identified
  7. 2010 High

    Identified clathrin heavy chain as the phospho-Ser558 reader that recruits TACC3 (with ch-TOG) to the spindle, and showed this is gated by the Ran/importin-β gradient.

    Evidence Co-IP, phospho-mutant analysis, domain mapping and Ran/importin-β competition assays

    PMID:20566684 PMID:20923838

    Open questions at the time
    • Stoichiometry and ultrastructure of the spindle complex not yet resolved
  8. 2011 High

    Demonstrated that TACC3-ch-TOG-clathrin forms a trimeric complex constituting the inter-microtubule bridges of kinetochore fibers, defining its structural role in K-fiber integrity.

    Evidence Co-IP, siRNA, EM ultrastructure and immunogold labeling

    PMID:21297582

    Open questions at the time
    • Distinction between structural crosslinking and tension generation not yet separated
  9. 2013 High

    Distinguished the complex's tension-maintenance role from its structural role and dissected the molecular surfaces, showing TACC3 and clathrin are interdependent and cooperatively form the microtubule-interaction surface, while ch-TOG engages via a sixth TOG domain.

    Evidence Knocksideways with FRET tension measurement; NMR, domain mapping, microtubule cosedimentation and biophysical reconstitution

    PMID:21966557 PMID:23532825 PMID:23887685 PMID:23918938 PMID:24003142 PMID:24273164

    Open questions at the time
    • Full atomic architecture of the assembled bridge not solved
    • Regulation of acentrosomal aster capture incompletely defined
  10. 2014 High

    Revealed two additional, complex-independent activities: TACC3 facilitates γ-TuRC assembly to nucleate centrosomal microtubules, and a TACC3-ch-TOG pool tracks microtubule plus ends with XMAP215.

    Evidence In vitro nucleation with recombinant TACC domain, Co-IP, sedimentation, and live +TIP imaging in Xenopus

    PMID:25187649 PMID:25246530

    Open questions at the time
    • How TACC3 partitions between nucleation, plus-tip tracking and spindle pools not quantified
  11. 2015 High

    Separated TACC3's two regulatory inputs to Aurora A using endogenous knock-ins: an F525 docking motif activates Aurora A and accelerates spindle assembly, while Ser558 phosphorylation prevents aneuploidy; also defined the clathrin- and Aurora A-independent TACC3-ch-TOG plus-tip pool.

    Evidence F525A/S558A knock-in mutagenesis, Aurora A activation assay, Co-IP, live imaging; separate live imaging/domain mapping for the independent pool

    PMID:25596274 PMID:26134678

    Open questions at the time
    • Physiological role of the plus-tip pool in human cells not fully defined
  12. 2018 High

    Provided the structural mechanism: a three-motif, phospho-dependent switch in which Aurora A docking, Ser558 phosphorylation-induced helix formation, and clathrin ankle recognition act sequentially to recruit TACC3.

    Evidence Crystal structure, NMR, mutagenesis and mitotic timing assays

    PMID:29510984

    Open questions at the time
    • Structure of the full ternary spindle complex on microtubules not resolved
  13. 2019 Medium

    Connected Ser558 phosphorylation to astral microtubule control by stabilizing γ-TuRC assembly at spindle poles through phospho-TACC3-γ-TuRC binding.

    Evidence S558A/S558D phospho-mutant overexpression, Co-IP with γ-TuRC proteins and live imaging

    PMID:31823729

    Open questions at the time
    • Overexpression-based, single lab
    • Direct vs scaffolded γ-TuRC contact not resolved
  14. 2021 High

    Refined the spindle complex membership using endogenous tagging, establishing TACC3 and clathrin as core and ch-TOG/GTSE1 as ancillary while excluding PIK3C2A.

    Evidence CRISPR knock-in tagging with systematic induced relocalization of endogenous proteins

    PMID:33380489

    Open questions at the time
    • Functional contribution of GTSE1 to the complex not detailed here
  15. 2023 High

    Defined cell-cycle-resolved TACC3 interactomes in cancer, with mitotic KIFC1-dependent centrosome clustering and interphase NuRD-mediated tumor-suppressor silencing both promoting tumor growth.

    Evidence Co-IP, PLA, ChIP, knockdown/CRISPR and organoid/PDX models

    PMID:36864125

    Open questions at the time
    • Direct vs indirect NuRD recruitment by TACC3 not structurally mapped
  16. 2018 Medium

    Characterized the oncogenic FGFR3-TACC3 fusion, showing it depends on FGFR3 kinase activity and secretory-pathway localization, sequesters endogenous TACC3 from the spindle, and rewires metabolism via a PIN4-PGC1α axis.

    Evidence Localization-targeting constructs, kinase-dead mutagenesis, phosphoproteomics, metabolic flux and in vivo tumor assays

    PMID:26869289 PMID:28855393 PMID:29323298 PMID:30344944

    Open questions at the time
    • Single labs per study
    • Relative contributions of spindle sequestration vs FGFR3 signaling to tumorigenesis not jointly quantified
  17. 2022 Medium

    Identified FGFR3-TACC3 as an HSP90/CDC37 client, nominating chaperone inhibition as a therapeutic vulnerability.

    Evidence Co-IP of the ternary complex, HSP90 inhibitor and CDC37 knockdown with glycosylation and viability assays

    PMID:35151844

    Open questions at the time
    • Single lab
    • Generality across fusion-positive tumor types not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How TACC3 is dynamically partitioned among its spindle-crosslinking, microtubule-nucleating, plus-tip-tracking, translational-repressor, and nuclear transcriptional roles within a single cell, and how these pools are coordinated, remains unresolved.
  • No integrated quantitative model of pool partitioning
  • Mendelian disease association absent from the corpus
  • Mechanism coupling nuclear and mitotic functions undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 4 GO:0140110 transcription regulator activity 4 GO:0045182 translation regulator activity 3 GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005634 nucleus 3 GO:0005815 microtubule organizing center 3 GO:0005856 cytoskeleton 3 GO:0005635 nuclear envelope 1
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-1643685 Disease 4 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-1852241 Organelle biogenesis and maintenance 2
Partners
AURKACKAP5CLTCFOG-1KIFC1MBD2NDEL1XMAP215
Complex memberships
NuRD complex (MBD2/HDAC2)TACC3-ch-TOG-clathrin spindle complexmaskin-eIF4E translational repression complexγ-TuRC

Evidence

Reading pass · 45 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 Maskin (TACC3 Xenopus ortholog) binds eIF4E and interacts with CPEB; this maskin-eIF4E interaction blocks eIF4G association with eIF4E, repressing translation of CPE-containing mRNAs such as cyclin B1 at the mitotic apparatus. CPEB also interacts with microtubules and is involved in localizing cyclin B1 mRNA to the mitotic apparatus. Co-immunoprecipitation, antibody injection assays, mRNA reporter injection, in situ localization in Xenopus embryos Cell High 11081630
2002 Maskin (TACC3 Xenopus ortholog) prevents oocyte maturation and translation of CPE-containing cyclin B1 mRNA by blocking eIF4G association with eIF4E. Dissociation of the maskin-eIF4E complex requires both cytoplasmic polyadenylation and poly(A)-binding protein (PABP), which binds eIF4G to displace maskin from eIF4E. Antibody injection, mRNA reporter injection, biochemical binding assays in Xenopus oocytes The EMBO journal High 12110596
2005 Aurora A (Eg2) phosphorylates maskin/TACC3 on a conserved serine residue; this phosphorylation regulates maskin localization to centrosomes and function in microtubule assembly during M-phase. Maskin interacts with XMAP215 and Aurora A kinase in vitro and in egg extracts. In vitro kinase assay, co-immunoprecipitation from egg extracts, depletion/reconstitution experiments in Xenopus egg extracts The Journal of cell biology High 16172207
2005 TACC3 (Xenopus) forms a one-to-one complex with XMAP215 and enhances XMAP215's microtubule-stabilizing activity in vitro. TACC3 increases the number of microtubules emanating from mitotic centrosomes, and its centrosomal targeting is regulated by Aurora A-dependent phosphorylation. Purified protein reconstitution, in vitro microtubule assay, Xenopus laevis egg extracts, Aurora A kinase assay The Journal of cell biology High 16172205
2005 Maskin (TACC3) interacts with XMAP215 in Xenopus egg extracts; maskin depletion results in mislocalization of XMAP215 but not CPEB, demonstrating that maskin is required for XMAP215 centrosome/spindle localization. Maskin is required for two distinct steps of spindle assembly and microtubule aster formation. Immunodepletion, add-back reconstitution, in vitro spindle assembly assay in Xenopus egg extracts, co-immunoprecipitation Molecular biology of the cell High 15788567
2005 Aurora A phosphorylates maskin (TACC3) on a conserved serine (Ser626 in Xenopus) in vitro and in vivo; inhibition of this phosphorylation by microinjection of phospho-mimicking peptides causes premature synthesis of meiosis II proteins (cyclin B1, Cdc6) during meiosis I, indicating maskin phosphorylation by Aurora A controls sequential protein synthesis during oocyte maturation. Two-hybrid screen (interaction identification), in vitro kinase assay, co-immunoprecipitation from oocyte extracts, microinjection of synthetic peptides, Western blot The Journal of biological chemistry High 15687499
2005 Maskin (TACC3) undergoes multiple CDK1-dependent phosphorylation events (at T58, S152, S311, S343, S453, S638) during oocyte maturation; mutation of these sites to alanine prevents CDK1-induced dissociation of maskin from eIF4E. Separately, Maskin is phosphorylated on S626 by protein kinase A prior to maturation, which is required for its localization on the mitotic apparatus in somatic cells but does not affect translation during oocyte maturation. Mass spectrometry phosphosite mapping, site-directed mutagenesis, co-immunoprecipitation, in vitro kinase assay, localization studies Molecular and cellular biology High 16107707
2006 CDK1 phosphorylation promotes maskin (TACC3) dissociation from eIF4E, while the phosphatase calcineurin reverses this. This phosphorylation-dephosphorylation cycle oscillates with the cell cycle and controls maskin-eIF4E interaction and, consequently, cyclin B1 mRNA translation during early Xenopus cell cycles. In vitro kinase/phosphatase assays, co-immunoprecipitation, cell-free translation assays in Xenopus embryo extracts Nature structural & molecular biology High 17086181
2006 NDEL1 is required for centrosome targeting of TACC3 through direct interaction with TACC3. Aurora A phosphorylates NDEL1 at Ser251, and expression of Aurora A phosphorylation-mimetic NDEL1 mutants rescues centrosomal maturation and separation defects caused by Aurora A depletion, including TACC3 recruitment. Co-immunoprecipitation, siRNA knockdown, phospho-mutant overexpression, immunofluorescence in mouse cells Molecular and cellular biology Medium 17060449
2007 Human TACC3 Ser558 is phosphorylated by Aurora A kinase; this phosphorylation is essential for TACC3 localization to centrosomes and proximal mitotic spindles in human cells. Inhibition of Aurora A with MLN8054 causes dose-dependent mislocalization of TACC3 away from mitotic spindles. In vitro kinase assay, site-directed mutagenesis, immunofluorescence, Aurora A small-molecule inhibitor treatment, in vivo tumor xenograft pharmacodynamic studies Cancer research High 17545617
2004 TACC3 interacts with FOG-1 (Friend of GATA-1) and controls FOG-1 nuclear localization. High levels of TACC3 inhibit FOG-1 function as a transcriptional cofactor of GATA-1. GATA-1 competes with TACC3 for interaction with FOG-1. Forced TACC3 overexpression delays terminal erythroid maturation. Co-immunoprecipitation, overexpression/knockdown in MEL and G1ER cells, nuclear/cytoplasmic fractionation, erythroid differentiation assays The Journal of biological chemistry Medium 15037632
2006 TACC3 forms a complex in vivo with MBD2 and the histone acetyltransferase pCAF. The TACC3/pCAF-containing MBD2 complex and the HDAC2-containing MBD2 complex are mutually exclusive. HAT activity associates with MBD2 in vivo and increases when TACC3 is overexpressed. TACC3 can reactivate transcription from MBD2-repressed methylated promoters by favoring formation of an HAT-containing MBD2 complex. Co-immunoprecipitation, HAT enzymatic assay, reporter gene assay, overexpression Nucleic acids research Medium 16410616
2008 Maskin (TACC3) is required for microtubule anchoring at the centrosome but not for regulating microtubule dynamics per se (dynamics were unaffected by maskin depletion in time-lapse experiments). The conserved C-terminal TACC domain is necessary and sufficient for centrosome function; the N-terminus inhibits TACC domain function. Xenopus egg extract immunodepletion, in vitro aster assembly assay, time-lapse video microscopy, domain add-back reconstitution Molecular biology of the cell High 18508920
2009 Cdh1, an activator of APC/C, interacts with TACC3 and controls TACC3 protein stability during mitotic exit. Depletion of Cdh1 prolonged TACC3 protein levels; alteration of Cdh1 levels correlated with changes in ubiquitinated TACC3. Multiple domains of TACC3 are involved in Cdh1-regulated degradation. Yeast two-hybrid screen, co-immunoprecipitation (in vitro and in vivo), siRNA knockdown, ubiquitination assay, domain mapping Cell cycle Medium 19823035
2010 Clathrin heavy chain (CHC) acts as an adaptor that binds Aurora A-phosphorylated TACC3 (pSer558) and recruits it to the mitotic spindle for microtubule stabilization. CHC binds phospho-S558 TACC3 via its linker domain and first CHC repeat. Depletion of CHC abolishes TACC3 spindle relocalization and causes loss of ch-TOG on spindles, disorganized spindles, and chromosome misalignment. Co-immunoprecipitation, siRNA knockdown, phospho-mutant analysis, immunofluorescence, domain mapping The Journal of cell biology High 20566684
2010 Clathrin heavy chain (CHC) specifically binds phosphorylated TACC3 (at Ser620 and Ser626 in Xenopus; not Ser33) and recruits it to spindle poles. This CHC-phospho-TACC3 interaction is inhibited by importin β and reversed by RanGTP, linking spindle assembly to Ran gradient signaling. Co-immunoprecipitation, RNAi knockdown, phospho-mutant analysis, Ran/importin-β biochemical assays, immunofluorescence Journal of cell science High 20923838
2010 Integrin-linked kinase (ILK) is required for centrosome clustering in cancer cells with supernumerary centrosomes. ILK performs its centrosome clustering activity through TACC3 and ch-TOG. A specific TACC3 phosphorylation site is required for centrosome clustering, and ILK regulates this TACC3 phosphorylation in an Aurora-A-dependent manner. siRNA knockdown, ILK inhibitors, live-cell imaging, immunofluorescence, phospho-mutant analysis Oncogene Medium 20838383
2010 TACC3 and TSC2 co-localize and co-purify with nuclear envelope components. TACC3 is necessary for proper localization of phospho-Ser939 TSC2 at spindle poles and cytokinetic bridges. TSC2 acts epistatically to TACC3 in regulating cell division. Loss of TACC3 or TSC2 causes nuclear envelope morphological alterations, abscission defects, and increased binucleated cells. Co-immunoprecipitation/interactome mapping, subcellular fractionation, immunofluorescence, siRNA knockdown, epistasis analysis, electron microscopy Cell cycle Medium 20237422
2011 TACC3, ch-TOG, and clathrin form a trimeric complex at kinetochore fibers (K-fibers). The complex is anchored to the spindle by TACC3 and ch-TOG. Clathrin depletion and TACC3 depletion both cause selective loss of short inter-microtubule bridges in K-fibers and general MT loss. Immunogold labeling confirmed clathrin is present at inter-MT bridges in K-fibers. Co-immunoprecipitation, siRNA knockdown, electron microscopy ultrastructural analysis, immunogold labeling The EMBO journal High 21297582
2012 DOCK7 interacts with TACC3 and antagonizes TACC3's microtubule growth-promoting function at centrosomes. DOCK7 silencing impedes neuronal differentiation and maintains cells as cycling progenitors; DOCK7 overexpression promotes differentiation. DOCK7 controls interkinetic nuclear migration of radial glial progenitors by opposing TACC3 centrosomal activity. Co-immunoprecipitation, in utero electroporation (gain/loss of function), immunofluorescence, live imaging in developing mouse cortex Nature neuroscience Medium 22842144
2013 Within the TACC3-ch-TOG-clathrin complex, TACC3 and clathrin are interdependent for spindle recruitment—each requires the other to be present to bind the spindle. The N-terminal domain of clathrin and the TACC domain of TACC3 together form a microtubule-interaction surface, coordinated by TACC3-clathrin binding mediated through a dileucine motif and Aurora A-phosphorylated Ser558 on TACC3 binding to the 'ankle' of clathrin. A stutter in the TACC3 coiled-coil interacts with a novel sixth TOG domain of ch-TOG required for ch-TOG microtubule localization. Domain mapping, co-immunoprecipitation, microtubule cosedimentation assay, NMR structural characterization, mutagenesis, cell-based localization assays The Journal of cell biology High 23918938
2013 The TACC domain of TACC3 contains two functionally distinct subdomains: CC1 (aa 414–530) mediates interaction with chTOG, while CC2 (aa 530–630) performs an intradomain interaction with the central repeat region of TACC3 that masks the TACC domain before effector binding. Aurora A kinase does not regulate TACC3-chTOG complex formation per se, but functions as a recruitment factor for the complex to centrosomes/proximal spindles. Purified recombinant protein biochemistry, gel filtration, analytical ultracentrifugation, in vitro binding assays, domain deletion/truncation mutagenesis The Journal of biological chemistry High 24273164
2013 TACC3 is essential for kinetochore capture during spindle assembly. TACC3-associated acentrosomal microtubule asters form near kinetochores and bind kinetochores as an initial capture step; sorting of these asters with centrosomal microtubules then leads to capture by centrosomal microtubules from both poles. siRNA knockdown, live-cell imaging, nocodazole washout experiments, immunofluorescence in HeLa cells Proceedings of the National Academy of Sciences of the United States of America Medium 24003142
2013 Aurora A kinase activity is required for localization of the TACC3/ch-TOG/clathrin complex to K-fibers. Inhibition of Aurora A with MLN8237 results in loss of clathrin and TACC3 from spindles, destabilization of K-fibers, and loss of inter-MT bridges, phenocopying TACC3 or clathrin depletion. Aurora A small-molecule inhibition (MLN8237), immunofluorescence, electron microscopy of K-fibers Communicative & integrative biology Medium 21966557
2013 Aurora A kinase activity is required for central spindle assembly during anaphase; TACC3 is identified as an Aurora A substrate essential for this process. Inhibiting Aurora A after bipolar spindle formation specifically disrupts central spindle (anaphase) assembly. Aurora A inhibitor treatment in anaphase cells, siRNA knockdown, immunofluorescence in Xenopus and human cells EMBO reports Medium 23887685
2013 Rapid removal of the TACC3-ch-TOG-clathrin complex from K-fibers at metaphase (using knocksideways) reduces kinetochore fiber tension and prevents spindle checkpoint satisfaction without causing significant loss of K-fiber microtubules, distinguishing a maintenance role in tension generation from a structural role in MT number. Knocksideways (rapid inducible protein relocalization), FRET-based tension measurements, immunofluorescence, live imaging Journal of cell science High 23532825
2014 TACC3 promotes microtubule nucleation at centrosomes and facilitates γ-tubulin ring complex (γ-TuRC) assembly. TACC3 mediates interactions with both γ-TuRC and γ-TuSC proteins. TACC3 depletion reduces γ-TuRC levels and increases γ-TuSC levels, indicating TACC3 is required for γ-TuRC assembly from γ-TuSC components. The TACC domain of TACC3 has intrinsic microtubule nucleating activity. siRNA knockdown, co-immunoprecipitation, microtubule sedimentation assay, immunofluorescence, recombinant TACC domain microtubule nucleation assay The Journal of biological chemistry High 25246530
2014 TACC3 functions as a microtubule plus end-tracking protein (+TIP) in multiple embryonic cell types via its conserved C-terminal TACC domain. TACC3 localizes distal to EB1 and directly overlaps with XMAP215 at plus ends. TACC3 promotes axon outgrowth by increasing microtubule plus end velocities. TACC3 also regulates XMAP215 stability and localizes XMAP215 to microtubule plus ends. Live fluorescence imaging with tagged +TIPs, morpholino knockdown/overexpression in Xenopus, domain truncation analysis Molecular biology of the cell Medium 25187649
2014 APC/C(CDH1) ubiquitin ligase mediates SNIPER(TACC3)-induced polyubiquitylation and proteasomal degradation of TACC3. This provides a mechanism for cell-cycle-regulated TACC3 turnover via ubiquitin-proteasome pathway. Mechanistic analysis with small molecule SNIPER(TACC3), ubiquitination assay, proteasome inhibitor rescue, CDH1-knockdown Cell death & disease Medium 25375378
2015 TACC3 contains a hydrophobic motif centered on F525 that docks to a previously uncharacterized pocket on Aurora A, potently activating Aurora A. Cells carrying homozygous F525A mutation show perturbed TACC3 localization, reduced Ser558 phosphorylation, weakened clathrin interaction, and markedly shorter mitosis due to rapid spindle assembly, without chromosome missegregation. By contrast, S558A mutation causes aneuploidy without major change in mitotic duration. Endogenous TACC3 knock-in mutagenesis (F525A, S558A), biochemical Aurora A activation assay, co-immunoprecipitation, immunofluorescence, time-lapse imaging PLoS genetics High 26134678
2015 TACC3-ch-TOG can track microtubule plus ends independently of clathrin and Aurora A-dependent Ser558 phosphorylation or EB1/EB3. This Aurora A/clathrin-independent pool is defined by the direct TACC3-ch-TOG interaction and is distinct from the TACC3-ch-TOG-clathrin spindle pool. Live fluorescence imaging, co-immunoprecipitation, siRNA knockdown, domain mapping Biology open Medium 25596274
2018 Aurora A recruits TACC3 to the mitotic spindle through a phospho-dependent three-motif mechanism: (1) a hydrophobic docking motif binds a novel pocket on Aurora A; (2) phosphorylation of Ser558 induces a conformational switch from disordered to helical in a second motif; (3) the resulting helix extends into a third motif recognized by the ankle helical-repeat region of clathrin heavy chain. Abrogation of the docking motif causes a delay in late mitosis. Crystal structure, NMR, mutagenesis, cell-based localization assays, mitotic timing assays The EMBO journal High 29510984
2019 Aurora A-specific phosphorylation of TACC3 at Ser558 regulates astral microtubule formation by stabilizing γ-TuRC assembly at spindle poles. S558A mutation causes loss of astral MTs and disrupts γ-TuRC protein localization at poles; S558D (phospho-mimetic) retains astral MTs and γ-TuRC proteins. Ser558-phosphorylated TACC3 physically interacts with γ-TuRC proteins, and S558A impairs this interaction. Phospho-mutant overexpression (S558A, S558D), co-immunoprecipitation with γ-TuRC proteins, immunofluorescence, time-lapse imaging BMC molecular and cell biology Medium 31823729
2010 Tacc3 binds to the intracellular domain of all Notch receptor family members via CDC10/Ankyrin repeats, co-localizes with Notch3 ICD in mammary tissue, and acts as a negative regulator of Notch signaling. Knockdown of Tacc3 upregulates the Notch target gene Hey2. Notch4/Int3 ICD-Tacc3 interaction inhibits transcription from a Hes1-Luciferase reporter, reversed by increasing Rbpj. Yeast two-hybrid, co-immunoprecipitation of endogenous proteins, dual-label immunofluorescence, siRNA knockdown, reporter gene assay Biochemical and biophysical research communications Medium 20804727
2017 In FGFR3-TACC3 (FT3) fusion-positive bladder cancer cells, the FT3 fusion protein is not localized to the mitotic spindle; instead, via its TACC domain, FT3 sequesters endogenous TACC3 away from the spindle, reducing spindle TACC3 levels. This depletion causes mitotic defects (chromosome segregation errors). Knockdown of the fusion gene or overexpression of TACC3 partially rescues these defects. FGFR3 kinase inhibition does not rescue spindle TACC3 levels, confirming the mechanism is TACC3-dominant rather than FGFR3 signaling-dependent. Immunofluorescence, siRNA knockdown of fusion gene, TACC3 overexpression rescue, FGFR3 inhibitor treatment, chromosome segregation assay in bladder cancer cell lines Open biology Medium 28855393
2021 TACC3 and clathrin are core members of the mitotic spindle complex; chTOG and GTSE1 are ancillary—chTOG binds TACC3 and GTSE1 binds clathrin, but chTOG and GTSE1 do not interact with each other. PIK3C2A, previously proposed to stabilize the complex, is not a member. This was established using induced relocalization of endogenous CRISPR-tagged complex members. CRISPR/Cas9 knock-in tagging, induced relocalization (knocksideways) of endogenous proteins, co-relocalization assay, immunofluorescence Journal of cell science High 33380489
2018 The oncogenic activity of FGFR3-TACC3 requires entrance to the secretory pathway or plasma membrane localization; nuclear-targeted or signal-sequence-deleted FGFR3-TACC3 lacks oncogenic activity. FGFR3-TACC3 transformation is not affected by its interactions with Aurora-A, clathrin, or ch-TOG. FGFR3 kinase activity (K508R abrogates) is essential for transformation; the TACC3 domain drives nuclear localization of the fusion. Subcellular localization targeting constructs (NLS, myristylation signal, signal sequence deletion), focus formation assay, IL-3 independent proliferation, Western blot signaling analysis Oncotarget Medium 30344944
2016 The coiled-coil TACC3 domain in FGFR3-TACC3 leads to constitutive phosphorylation of key activating FGFR3 tyrosine residues (shown by TiO2-LC-MS/MS phosphoproteomics). FGFR3-TACC3 causes increased FGFR3 activation, altered phosphorylation, MAPK pathway activation, nuclear localization, and cellular transformation. The TACC3 domain alone drives nuclear localization; FGFR3 kinase activity is required for transformation (K508R mutation abrogates it). Phosphorylated tyrosines in the TACC3-derived portion are not critical for activity. TiO2-LC-MS/MS phosphopeptide enrichment, kinase-dead mutagenesis, focus formation assay, Western blot, nuclear localization assays Molecular cancer research Medium 26869289
2018 The FGFR3-TACC3 fusion activates oxidative phosphorylation and mitochondrial biogenesis via phosphorylation of PIN4 as an intermediate signaling step. The F3-T3-PIN4 axis triggers peroxisome biogenesis and new protein synthesis; this anabolic response converges on PGC1α through intracellular ROS production, enabling mitochondrial respiration and tumor growth. Transcriptional subgroup analysis, phosphoproteomics, metabolic flux assays, organelle biogenesis assays, ROS measurement, in vivo tumor growth assays Nature Medium 29323298
2022 The FGFR3-TACC3 fusion protein is a client of HSP90, forming a ternary complex with CDC37. Deprivation of HSP90 or CDC37 disrupts this ternary complex, destabilizes glycosylated FGFR3-TACC3, and suppresses its oncogenic activity. HSP90 inhibitors sensitize FGFR3-TACC3-positive glioma cells to temozolomide. Co-immunoprecipitation of HSP90/CDC37/F3T3, HSP90 inhibitor treatment, CDC37 knockdown, cell viability assays, glycosylation analysis Molecular therapy Medium 35151844
2020 TACC3 promotes prostate cancer cell proliferation and restrains primary cilium formation. TACC3 interacts with filamin A; elevated TACC3 disrupts the filamin A-meckelin interaction, thereby restraining primary cilium formation. Co-immunoprecipitation, siRNA knockdown, immunofluorescence, in vitro and in vivo proliferation assays Experimental cell research Medium 32156598
2021 The 5' UTR of Tacc3 mRNA contains upstream open reading frames (uORFs) that direct P-eIF2α-dependent translation, enabling preferential Tacc3 protein synthesis under conditions of elevated eIF2α phosphorylation. TACC3-deficient satellite cells exhibit defects in expansion, self-renewal, and skeletal muscle regeneration. Transcriptomics, quantitative proteomics, 5' UTR reporter assays, sal003 pharmacological treatment, TACC3 conditional knockout in satellite cells Development Medium 33318147
2023 TACC3 forms distinct functional interactomes in mitosis and interphase in cancer cells with centrosome amplification. In mitosis, TACC3 interacts with KIFC1 (a kinesin) to cluster extra centrosomes; disrupting this interaction causes multipolar spindle formation and mitotic cell death. In interphase, TACC3 interacts with the NuRD complex (HDAC2 and MBD2) in the nucleus to suppress expression of tumor suppressors (p21, p16, APAF1), driving G1/S progression. FOXM1 drives upregulation of TACC3 and KIFC1 in response to p53 loss/centrosome amplification. Co-immunoprecipitation, proximity ligation assay, siRNA/CRISPR knockdown, ChIP, qRT-PCR, immunofluorescence, organoid and PDX tumor models Cell death and differentiation High 36864125
2018 TACC3 inhibition in T-DM1-resistant HER2+ breast cancer cells restores spindle assembly checkpoint (SAC)-dependent immunogenic cell death (ICD). TACC3 overexpression in resistant cells abolishes SAC activation and ICD markers. In vivo, TACC3 inhibition elicited ICD and enhanced T-DM1 antitumor activity by inducing dendritic cell maturation and increasing intratumoral cytotoxic T cells. TACC3 siRNA/inhibitor, flow cytometry (calreticulin, ATP, HMGB1 release), vaccination assay, in vivo tumor models with immune profiling Cancer research Medium 38319231
2018 HURP directly interacts with TACC3 (mapped to HURP residues 1–625) in vivo and in vitro. HURP is required for TACC3 function during kinetochore microtubule assembly at the chromosome region in prometaphase; HURP modulates stable lateral kinetochore attachment and chromosome congression through TACC3. Co-immunoprecipitation, bimolecular fluorescence complementation, siRNA knockdown, immunofluorescence The Journal of biological chemistry Medium 30054275

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division. Cell 238 11081630
2005 Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis. The Journal of cell biology 219 16172205
2013 The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. The Journal of clinical investigation 192 23298836
2002 Dissolution of the maskin-eIF4E complex by cytoplasmic polyadenylation and poly(A)-binding protein controls cyclin B1 mRNA translation and oocyte maturation. The EMBO journal 178 12110596
2018 A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature 161 29323298
2011 A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. The EMBO journal 132 21297582
2006 NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Molecular and cellular biology 124 17060449
2005 Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis. The Journal of cell biology 118 16172207
1999 The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. Genomics 114 10366448
2016 FGFR3-TACC3 fusion in solid tumors: mini review. Oncotarget 113 27409839
2007 Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity. Cancer research 108 17545617
2013 TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways. Cancer letters 103 23348690
2002 The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. The EMBO journal 102 11847113
2014 Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 93 25294908
2014 Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway. Cell death & disease 87 25375378
2010 Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes. Oncotarget 86 21113414
2012 DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nature neuroscience 81 22842144
2010 A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells. Oncogene 78 20838383
2010 Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability. The Journal of cell biology 76 20566684
2014 Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma. Cancer biology & therapy 75 25535896
2016 Oncogenic Gene Fusion FGFR3-TACC3 Is Regulated by Tyrosine Phosphorylation. Molecular cancer research : MCR 74 26869289
2013 Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding. The Journal of cell biology 68 23918938
2005 Aberrations of TACC1 and TACC3 are associated with ovarian cancer. BMC women's health 67 15918899
2013 Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. Journal of cell science 65 23532825
2013 Aurora A kinase and its substrate TACC3 are required for central spindle assembly. EMBO reports 60 23887685
2010 Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment. Journal of cell science 59 20923838
2005 The Xenopus TACC homologue, maskin, functions in mitotic spindle assembly. Molecular biology of the cell 59 15788567
2015 FGFR3-TACC3: A novel gene fusion in cervical cancer. Gynecologic oncology reports 58 26425723
2005 Differential phosphorylation controls Maskin association with eukaryotic translation initiation factor 4E and localization on the mitotic apparatus. Molecular and cellular biology 58 16107707
2004 Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. The Journal of biological chemistry 58 15037632
2006 TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters. Nucleic acids research 57 16410616
2020 Clinical, molecular, and radiomic profile of gliomas with FGFR3-TACC3 fusions. Neuro-oncology 56 32413119
2017 Emergence of FGFR3-TACC3 fusions as a potential by-pass resistance mechanism to EGFR tyrosine kinase inhibitors in EGFR mutated NSCLC patients. Lung cancer (Amsterdam, Netherlands) 54 28838400
2017 Diffuse gliomas with FGFR3-TACC3 fusion have characteristic histopathological and molecular features. Brain pathology (Zurich, Switzerland) 54 28976058
2016 FGFR3-TACC3 fusion proteins act as naturally occurring drivers of tumor resistance by functionally substituting for EGFR/ERK signaling. Oncogene 51 27345413
2014 TACC3 is a microtubule plus end-tracking protein that promotes axon elongation and also regulates microtubule plus end dynamics in multiple embryonic cell types. Molecular biology of the cell 49 25187649
2018 Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions. Oncogenesis 48 29358619
2018 Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix. The EMBO journal 48 29510984
2013 TACC3 is essential for EGF-mediated EMT in cervical cancer. PloS one 48 23936413
2003 TACC3 expression is tightly regulated during early differentiation. Gene expression patterns : GEP 48 12711550
2005 Phosphorylation of maskin by Aurora-A participates in the control of sequential protein synthesis during Xenopus laevis oocyte maturation. The Journal of biological chemistry 47 15687499
2010 The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene 44 20729911
2020 Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions. Acta neuropathologica communications 43 33168106
2015 Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly. PLoS genetics 43 26134678
2011 Pulling it together: The mitotic function of TACC3. Bioarchitecture 43 21922039
2017 The role of TACC3 in mitotic spindle organization. Cytoskeleton (Hoboken, N.J.) 41 28745816
2009 Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells. Oncology reports 41 19148534
2006 CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression. Nature structural & molecular biology 41 17086181
2015 TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma. Oncotarget 39 26219398
2012 Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS chemical biology 39 23240775
2015 TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation. Biology open 38 25596274
2004 Correlation of TACC3, FGFR3, MMSET and p21 expression with the t(4;14)(p16.3;q32) in multiple myeloma. British journal of haematology 37 15198734
2013 The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner. The Journal of biological chemistry 36 24273164
2011 Disruption of Tacc3 function leads to in vivo tumor regression. Oncogene 36 21685933
2014 TACC3 protein regulates microtubule nucleation by affecting γ-tubulin ring complexes. The Journal of biological chemistry 35 25246530
2013 A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells. Oncogene 35 24077290
2007 TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton. Cancer science 35 17359303
2007 TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene 35 17599038
2020 Targeted Therapy with Anlotinib for a Patient with an Oncogenic FGFR3-TACC3 Fusion and Recurrent Glioblastoma. The oncologist 34 32949176
2010 TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Cell cycle (Georgetown, Tex.) 34 20237422
2017 SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib. Cancer science 33 28192613
2018 Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling. Oncotarget 32 30344944
2011 Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin inter-microtubule bridges. Communicative & integrative biology 32 21966557
2024 Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer. Cancer research 29 38319231
2001 Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells. British journal of haematology 29 11298601
2023 Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification. Cell death and differentiation 28 36864125
2008 Xenopus TACC3/maskin is not required for microtubule stability but is required for anchoring microtubules at the centrosome. Molecular biology of the cell 28 18508920
2020 TACC3 promotes prostate cancer cell proliferation and restrains primary cilium formation. Experimental cell research 27 32156598
2018 TACC3 transcriptionally upregulates E2F1 to promote cell growth and confer sensitivity to cisplatin in bladder cancer. Cell death & disease 25 29358577
2017 FGFR3-TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle. Open biology 25 28855393
2015 Suppression of centrosome protein TACC3 induces G1 arrest and cell death through activation of p38-p53-p21 stress signaling pathway. European journal of cell biology 25 25613365
2020 A Highly Potent TACC3 Inhibitor as a Novel Anticancer Drug Candidate. Molecular cancer therapeutics 24 32217742
2013 Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly. Proceedings of the National Academy of Sciences of the United States of America 24 24003142
2009 Cdh1 controls the stability of TACC3. Cell cycle (Georgetown, Tex.) 24 19823035
2002 TACC3 expression and localization in the murine egg and ovary. Molecular reproduction and development 24 12237944
2023 Clinico-pathological and epigenetic heterogeneity of diffuse gliomas with FGFR3::TACC3 fusion. Acta neuropathologica communications 23 36647073
2016 Development of RNA-FISH Assay for Detection of Oncogenic FGFR3-TACC3 Fusion Genes in FFPE Samples. PloS one 23 27930669
2014 TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibition. Oncogene 22 24769898
2020 RNAi technology targeting the FGFR3-TACC3 fusion breakpoint: an opportunity for precision medicine. Neuro-oncology advances 21 33241214
2015 TACC3 Is Important for Correct Progression of Meiosis in Bovine Oocytes. PloS one 20 26168150
2018 Inhibition of TACC3 by a small molecule inhibitor in breast cancer. Biochemical and biophysical research communications 19 29555478
2016 Knockdown of TACC3 inhibits trophoblast cell migration and invasion through the PI3K/Akt signaling pathway. Molecular medicine reports 19 27572091
2003 Aint/Tacc3 is highly expressed in proliferating mouse tissues during development, spermatogenesis, and oogenesis. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 19 12642624
2010 Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats. Biochemical and biophysical research communications 18 20804727
2021 Defining endogenous TACC3-chTOG-clathrin-GTSE1 interactions at the mitotic spindle using induced relocalization. Journal of cell science 17 33380489
2018 Enrichment of FGFR3-TACC3 Fusions in Patients With Bladder Cancer Who Are Young, Asian, or Have Never Smoked. JCO precision oncology 17 33604498
2003 Recognition of two genetic groups in the Klebsiella oxytoca taxon on the basis of chromosomal beta-lactamase and housekeeping gene sequences as well as ERIC-1 R PCR typing. International journal of systematic and evolutionary microbiology 17 12807183
2007 Translational control of maskin mRNA by its 3' untranslated region. Biology of the cell 16 17241108
2022 HSP90-CDC37 functions as a chaperone for the oncogenic FGFR3-TACC3 fusion. Molecular therapy : the journal of the American Society of Gene Therapy 15 35151844
2019 Aurora A site specific TACC3 phosphorylation regulates astral microtubule assembly by stabilizing γ-tubulin ring complex. BMC molecular and cell biology 15 31823729
2018 FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium. Oncogene 15 29991799
2017 The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development. Neural development 15 28202041
2023 Successful Treatment and Retreatment With Erdafitinib for a Patient With FGFR3-TACC3 Fusion Squamous NSCLC: A Case Report. JTO clinical and research reports 13 37214414
2022 Glioblastoma, IDH-Wild Type With FGFR3-TACC3 Fusion: When Morphology May Reliably Predict the Molecular Profile of a Tumor. A Case Report and Literature Review. Frontiers in neurology 13 35222252
2021 Satellite cell expansion is mediated by P-eIF2α-dependent Tacc3 translation. Development (Cambridge, England) 13 33318147
2018 The microtubule-associated protein HURP recruits the centrosomal protein TACC3 to regulate K-fiber formation and support chromosome congression. The Journal of biological chemistry 13 30054275
2024 TACC3: a multi-functional protein promoting cancer cell survival and aggressiveness. Cell cycle (Georgetown, Tex.) 12 38197196
2021 Precise editing of FGFR3-TACC3 fusion genes with CRISPR-Cas13a in glioblastoma. Molecular therapy : the journal of the American Society of Gene Therapy 12 34274537
2023 Polymorphous low-grade neuroepithelial tumor of the young with FGFR3-TACC3 fusion mimicking high-grade glioma: case report and series of high-grade correlates. Frontiers in oncology 11 38074682
2020 Whole-exome sequencing reveals potential mechanisms of drug resistance to FGFR3-TACC3 targeted therapy and subsequent drug selection: towards a personalized medicine. BMC medical genomics 11 32957974

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